192 results on '"Hyun Joo Song"'
Search Results
2. Exposure to Foreign Languages through Live Interaction Can Facilitate Children’s Acceptance of Multiple Labeling Conventions across Languages
- Author
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Hyuna, Lee and Hyun-Joo, Song
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Linguistics and Language ,Developmental and Educational Psychology ,Experimental and Cognitive Psychology ,General Psychology ,Language and Linguistics - Abstract
The current research examined whether children’s expectations about labeling conventions can be influenced by limited exposure to a foreign language. Three- to four-year-old Korean children were presented with two speakers who each assigned a novel label either in Korean or Spanish to a novel object. Children were asked whether both labels were acceptable for the object. Children who had more exposure to a foreign language through live social interaction, but not through media, were more likely to accept both Korean and Spanish labels. These findings indicate the influence of social interaction in foreign language exposure on children’s understanding of different labeling conventions.
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- 2022
3. Korean Association for the Study of Intestinal Diseases guidance for clinical practice of adult inflammatory bowel disease during the coronavirus disease 2019 pandemic: expert consensus statements
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Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, and Seung-Jae Myung
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Gastroenterology - Abstract
Many unexpected problems have resulted from the unprecedented coronavirus disease 2019 (COVID-19) pandemic. The optimal management of patients with inflammatory bowel disease (IBD) during the COVID-19 pandemic has also been a challenge. Therefore, the Korean Association for the Study of Intestinal Diseases (KASID) developed a consensus statement of experts regarding the management of IBD during the COVID-19 pandemic. This consensus statement made recommendations regarding the risk and treatment of COVID-19 in IBD patients. This statement emphasizes that IBD is not a risk factor for COVID-19, and care should be taken not to exacerbate IBD in patients in remission state by maintaining their medications, except for corticosteroids.
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- 2022
4. Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions
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Soo-Young Na, Ki Bae Kim, Yun Jeong Lim, and Hyun Joo Song
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General Materials Science - Abstract
Vitamin D is considered to be the main mediator of the beneficial effects of sun exposure. In humans, highest expression of Vitamin D receptors is found in the intestinal tract. In addition, 1α,25-dihydroxyvitamin D3 (or calcitriol), the most active Vitamin D metabolite, plays important homeostatic roles in the intestine, particularly calcium absorption. Vitamin D deficiency is defined as a serum 25-hydroxyvitamin D [25(OH)D] level of20 ng/mL. Previous studies show that higher circulating 25(OH)D levels are associated with reduced risk of colorectal cancer (CRC) and improved survival. Most research to date has been conducted in animals, specifically mice. Although human studies have a limited number of participants, one study recruiting a large cohort of patients with advanced or metastatic CRC revealed that higher plasma 25(OH)D levels are associated with improved overall and progression-free survival. However, the effects of Vitamin D supplementation on incidence and mortality of CRC remain inconclusive. Although Vitamin D may help to prevent cancer, there is a paucity of research demonstrating conclusively that Vitamin D alters prognosis after chemotherapy. Here, we review the mechanisms by which Vitamin D affects CRC, as well as the results of clinical, epidemiological, and human intervention studies. We also discuss current perspectives and future directions regarding Vitamin D and CRC.
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- 2022
5. Comparative outcomes of acute colonic diverticulitis in immunocompromised versus immunocompetent patients: a systematic review and meta-analysis
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Jae Gon Lee, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Shin Hee Lee, Myung-Won You, and Seong-Eun Kim
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Gastroenterology - Published
- 2023
6. Culture, executive functions, and academic achievement
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Isu Cho, Niki Hosseini-Kamkar, Hyun-joo Song, and J. Bruce Morton
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General Psychology - Abstract
Although it is well known that children of East Asian immigrants show higher academic achievement than native-born North American children, the social-cognitive determinants of this difference remain poorly understood. Given the importance of executive functions (EF) for academic achievement, and evidence that EF develops more quickly in East Asian compared to North American cultures, it is conceivable that differences in academic achievement might be rooted in EF differences between these groups. We examine this possibility by reviewing evidence of cross-cultural differences in EF development but find core concepts and findings limited in several key respects. To address these limitations, we propose a framework for relating EF, culture, and academic achievement that draws on new theoretical ideas about the nature of EF and its relation to social context. We conclude by discussing avenues for future research on the relations between culture, executive functions, and academic achievement.
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- 2023
7. Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
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Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Geom Seog Seo, Chang Hwan Choi, Hyun Joo Song, Gwang Ho Baik, Ji Won Kim, Sung Jae Shin, Young Sook Park, Chang Kyun Lee, Jun Lee, Sung Hee Jung, Yunho Jung, Sung Chul Park, Young-Eun Joo, Yoon Tae Jeen, Dong Soo Han, Suk-Kyun Yang, Hyo Jong Kim, Won Ho Kim, and Joo Sung Kim
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Cohort Studies ,Crohn Disease ,Hepatology ,Gastroenterology ,Humans ,Prospective Studies ,Prognosis ,Follow-Up Studies ,Retrospective Studies - Abstract
The prospective Crohn's Disease Clinical Network and Cohort Study is a nationwide multicenter cohort study of patients with Crohn's disease (CD) in Korea, aiming to prospectively investigate the clinical features and long-term prognosis associated with CD.Patients diagnosed with CD between January 2009 and September 2019 were prospectively enrolled. They were divided into two cohorts according to the year of diagnosis: cohort 1 (diagnosed between 2009 and 2011) versus cohort 2 (between 2012 and 2019).A total of 1,175 patients were included, and the median follow-up duration was 68 months (interquartile range, 39.0 to 91.0 months). The treatment-free durations for thiopurines (p0.001) and anti-tumor necrosis factor agents (p=0.018) of cohort 2 were shorter than those of cohort 1. Among 887 patients with B1 behavior at diagnosis, 149 patients (16.8%) progressed to either B2 or B3 behavior during follow-up. Early use of thiopurine was associated with a reduced risk of behavioral progression (adjusted hazard ratio [aHR], 0.69; 95% confidence interval [CI], 0.50 to 0.90), and family history of inflammatory bowel disease was associated with an increased risk of behavioral progression (aHR, 2.29; 95% CI, 1.16 to 4.50). One hundred forty-one patients (12.0%) underwent intestinal resection, and the intestinal resection-free survival time was significantly longer in cohort 2 than in cohort 1 (p=0.003). The early use of thiopurines (aHR, 0.35; 95% CI, 0.23 to 0.51) was independently associated with a reduced risk of intestinal resection.The prognosis of CD in Korea appears to have improved over time, as evidenced by the decreasing intestinal resection rate. Early use of thiopurines was associated with an improved prognosis represented by a reduced risk of intestinal resection.
- Published
- 2022
8. News Media’s Ideological Orientation and Their Moral System : Comparison of Editorials of 《Chosun-Ilbo》 and 《Hankyoreh》
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Hyun-Joo Song
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- 2022
9. KASID Guidance for Clinical Practice Management of Adult Inflammatory Bowel Disease during the COVID-19 Pandemic: Expert Consensus Statement
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Hee Chan Yang, Young Joo Yang, Ji Young Chang, Seung-Jae Myung, Yoo Jin Lee, Duk Hwan Kim, Byung Chang Kim, Jae Gon Lee, Miyoung Choi, Yong Eun Park, Seong Eun Kim, and Hyun Joo Song
- Subjects
Adult ,Practice Management ,Chronic condition ,medicine.medical_specialty ,Consensus ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,business.industry ,Statement (logic) ,COVID-19 ,Disease Management ,General Medicine ,Disease ,Inflammatory Bowel Diseases ,medicine.disease ,Inflammatory bowel disease ,Health care ,Pandemic ,medicine ,Humans ,Disease management (health) ,business ,Intensive care medicine ,Pandemics ,Societies, Medical - Abstract
The coronavirus disease 2019 (COVID-19) pandemic has reduced the ability to prevent or control chronic disease due to the concerns about safety in accessing health care. Inflammatory bowel disease (IBD) is a chronic condition requiring long- term sustained treatment, which is difficult in the current panedemic situation. The Korean Association for the Study of Intestinal Diseases (KASID) has developed an expert consensus statement on the clinical practice management of adult inflammatory bowel disease during the COVID-19 pandemic. This expert consensus statement is based on guidelines and clinical reports from several countries around the world. It provides recommendations to deal with the risk of COVID-19 and medication use in IBD patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and emphasizes the importance of right treatment approach to avoid worsening of the disease condition in IBD patients.
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- 2021
10. The Sociomoral Evaluation of Inconsistent Agents
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Yomyong Cha and Hyun-joo Song
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Psychology ,Developmental psychology - Published
- 2021
11. Theorizing the Politics-Press Relations into Mediatization of Politics : Commentary on Hang-Je Cho’s 《Democracy and the Press in Korea》 (2020)
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Hyun-Joo Song
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Politics ,media_common.quotation_subject ,Political science ,Religious studies ,Democracy ,media_common - Published
- 2021
12. The Art Therapy Experiences of Patients and Their Family Members in Hospice Palliative Care
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Sungeun Park and Hyun-Joo Song
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Quality of life (healthcare) ,Palliative care ,Nursing ,business.industry ,Art therapy ,Medicine ,business ,Hospice care ,Grounded theory - Published
- 2020
13. Current issues in Korean morphology acquisition: A review of Chang et al
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Hyun Joo Song and Hyunkyung Yu
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General Medicine ,Language acquisition ,Psychology ,Competence (human resources) ,Cognitive psychology - Published
- 2020
14. Positive Fecal Occult Blood Test is a Predictive Factor for Gastrointestinal Bleeding after Capsule Endoscopy in Patients with Unexplained Iron Deficiency Anemia: A Korean Multicenter CAPENTRY Study
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Yun Jeong Lim, Hyun Joo Song, Ji Hyun Kim, Soo Jung Park, Ki Nam Shim, Seong Ran Jeon, Hyun Joo Jang, Chang Mo Moon, Dae Young Cheung, Hyun Seok Lee, Kyeong Ok Kim, and Ji Young Chang
- Subjects
lcsh:Internal medicine ,medicine.medical_specialty ,Gastrointestinal bleeding ,Anemia ,Medicine (miscellaneous) ,Gastroenterology ,law.invention ,03 medical and health sciences ,Fecal occult blood test ,0302 clinical medicine ,Capsule endoscopy ,law ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,lcsh:RC799-869 ,lcsh:RC31-1245 ,business.industry ,Medical record ,Hazard ratio ,Fecal occult blood ,medicine.disease ,Confidence interval ,Iron-deficiency anemia ,030220 oncology & carcinogenesis ,Iron deficiency anemia ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,Original Article ,business ,Predictive factors - Abstract
Background/aims Capsule endoscopy (CE) is recommended as the primary method for the evaluation of unexplained anemia. This study aimed to assess the diagnostic yield of CE in patients with unexplained iron deficiency anemia (IDA) without overt bleeding, and to evaluate their long-term outcomes and related clinical factors. Methods Data of patients who underwent CE for the evaluation of IDA were reviewed from a CE registry in Korea. Additional clinical data were collected by the involved investigators of each hospital through a review of medical records. Results Among a total of 144 patients, the diagnostic yield of CE was 34%. Gastrointestinal (GI) bleeding was found in 6.3% (n=9) of the patients (occult bleeding in four patients and overt bleeding in five patients) during a mean follow-up of 17.8 months. Patients with a positive fecal occult blood test (FOBT) result at the initial diagnosis had a higher rate of GI bleeding after CE (p=0.004). In addition, a positive FOBT result was the only independent predictive factor for GI bleeding (hazard ratio, 5.30; 95% confidence interval, 1.41-19.85; p=0.013). Conclusion Positive FOBT is a predictive factor for GI bleeding during follow-up after CE in patients with unexplained IDA without overt bleeding. Thus, patients with positive FOBT need to be more closely followed up.
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- 2020
15. Priming Behavioral Control Enhances Sharing in Preschoolers
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Chanmi Lee and Hyun-joo Song
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General Psychology - Abstract
Although young children demonstrate knowledge of fairness norms, their actual sharing is often inconsistent with their understanding. A possible explanation for this discrepancy is the failure of behavioral control in young children. Thus, the present research manipulated behavioral control experimentally and examined its effect on the sharing behavior in 3- to 4-year-olds (N = 64). Children were randomly assigned to either the behavioral control or the neutral prime conditions. In the behavioral control prime condition, the children listened to a story in which a protagonist exerted behavioral control actively, refraining from eating candies. In the neutral prime condition, the children listened to a story in which a protagonist did not explicitly engage in behavioral control. The children then participated in the dictator game. The experimenter asked the children to share as many stickers as they wanted or should with an anonymous child. Children in the behavioral control prime condition shared more stickers than those in the neutral prime condition. However, the two groups did not differ in their judgments of fairness and emotional experiences. The current research provides evidence that preschoolers’ sharing behaviors can be facilitated by behavioral control.
- Published
- 2022
16. Intramural esophageal dissection after endoscopy: a case report in a hypopharyngeal cancer patient treated with concurrent chemoradiotherapy
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Jae Hwi Park, Miok Kim, Sun Young Jeong, Hyun Joo Song, and Su yeon Ko
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Hypopharyngeal cancer ,Dissection (medical) ,medicine.disease ,Concurrent chemoradiotherapy ,Endoscopy ,medicine.anatomical_structure ,medicine ,Radiology ,Esophagus ,business ,Chemoradiotherapy - Published
- 2020
17. Do infants expect others to be helpful?
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Eun Young Kim, Hyun Joo Song, and Woo-Yeol Lee
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Male ,Statement (logic) ,Event (relativity) ,05 social sciences ,Infant ,Anticipation, Psychological ,Helping Behavior ,050105 experimental psychology ,Test (assessment) ,Social group ,Child Development ,Social Perception ,Developmental Neuroscience ,Developmental and Educational Psychology ,Humans ,Female ,0501 psychology and cognitive sciences ,Psychology ,Social psychology ,050104 developmental & child psychology - Abstract
This study examined whether infants assume that people will help others to achieve specific goals. Seventeen-month-old infants watched familiarization events in which a competent agent succeeded in climbing hills while an incompetent agent failed to do so. In subsequent test events, the competent agent either helped the incompetent agent reach the top of the hill (helping event) or simply passed the incompetent agent and reached the top of the hill alone (ignoring event). The infants looked reliably longer at the ignoring event than at the helping event. These findings suggest that, by at least the age of 17 months, infants expect a competent agent to help an incompetent agent. Our findings provide evidence that infants in their second year of life possess some expectations of others' prosociality. Statement of contribution What is already known? Infants begin to reliably produce helping behaviours during their second year of life. Infants expect others to help an agent who is in need, not one who is not in need. Infants expect others to help, not ignore, another in need when linguistic information explicitly signals that the agent and the recipient belong to the same social group. What the present study adds? Infants expect someone to provide help rather than to ignore another in need under some circumstances with no linguistic information about their social group membership. Infants expect an agent to be a helper, not a bystander, even when they lack information about the agent's moral characteristics.
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- 2020
18. A Comparison of Accuracy between IMMULITE2000® and GENEDIA® for Helicobacter pylori Infection
- Author
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Hyun Joo Song, Gwang Ho Baik, Seon Hee Lim, Hyun-Jin Kim, Kyung Sik Park, Sungeun Kim, Jeong Eun Shin, Suck Chei Choi, Dae Seong Myung, Nayoung Kim, and Ju Yup Lee
- Subjects
Helicobacter pylori infection ,lcsh:Internal medicine ,biology ,business.industry ,serology ,Helicobacter pylori ,biology.organism_classification ,Virology ,Serology ,03 medical and health sciences ,0302 clinical medicine ,immunoenzyme techniques ,030220 oncology & carcinogenesis ,Immunoenzyme techniques ,Medicine ,030211 gastroenterology & hepatology ,enzyme-linked immunosorbent assay ,business ,lcsh:RC31-1245 - Abstract
Background/Aims: In serological tests for Helicobacter pylori (H. pylori), an enzyme-linked immunosorbent assay (GENEDIA®) and a solid-phase, two-step chemiluminescent enzyme immunoassay (IMMULITE®), which are easy to perform, inexpensive, and widely available, are commonly used. However, local validation of the test performance of IMMULITE® is required. This study aimed to examine the performance of IMMULITE® in comparison with that of GENEDIA® in a Korean health checkup population.Materials and Methods: The sera of 300 subjects among those who underwent health checkup were analyzed using IMMULITE®, and results were compared with those of GENEDIA®. The two serological tests were compared for their ability to predict atrophic gastritis (AG) or intestinal metaplasia (IM) on endoscopy.Results: We found significant correlation (Pearson correlation coefficient=0.903, PP® and IMMULITE®. The area under the receiver operating characteristics curve (AUC) for AG using GENEDIA® and IMMULITE® were 0.590 and 0.604, respectively, and showed no statistically significant difference in predictive ability for AG (Z-statistics=-0.517, P=0.605). The AUC for IM by GENEDIA® and IMMULITE® were 0.578 and 0.593, respectively, with no statistically significant difference in predictive ability for IM between the two values (Z-statistics=-0.398, P=0.691).Conclusions: No statistically significant difference in diagnostic value for H. pylori infection was found between GENEDIA® and IMMULITE®.
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- 2020
19. Hemodynamically Stable Acute or Chronic Small-Bowel Bleeding
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Hyun Joo Song
- Published
- 2022
20. Update on SARS-CoV-2 vaccination of patients with inflammatory bowel disease: what clinicians need to know
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Yoo Jin, Lee, Seong-Eun, Kim, Yong Eun, Park, Ji Young, Chang, Hyun Joo, Song, Duk Hwan, Kim, Young Joo, Yang, Byung Chang, Kim, Jae Gon, Lee, Hee Chan, Yang, and Seung-Jae, Myung
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Gastroenterology - Published
- 2021
21. UPPER GASTROINTESTINAL INVOLVEMENT OF BEHCET'S DISEASE
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Hogyung Jun, Hyun Joo Song, Sun-Jin Boo, and Heung Up Kim
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Gastroenterology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
22. Efficacy of a comprehensive binary classification model using a deep convolutional neural network for wireless capsule endoscopy
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Jun-Seok Park, Ki Bae Kim, Hyun Joo Song, Ji Hyung Nam, Yun Jeong Lim, Dong Jun Oh, Youngbae Hwang, and Sang Hoon Kim
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Adult ,Male ,Adolescent ,Computer science ,Science ,Capsule Endoscopy ,Convolutional neural network ,Article ,Inflammatory bowel disease ,law.invention ,Set (abstract data type) ,Young Adult ,Capsule endoscopy ,law ,Machine learning ,Humans ,Small bowel disease ,Wireless ,Gastrointestinal bleeding ,Aged ,Retrospective Studies ,Aged, 80 and over ,Multidisciplinary ,Artificial neural network ,business.industry ,Gastroenterology ,Contrast (statistics) ,Pattern recognition ,Middle Aged ,Prognosis ,Intestinal Diseases ,Binary classification ,Medicine ,Female ,Neural Networks, Computer ,Artificial intelligence ,business ,Algorithms ,Follow-Up Studies - Abstract
The manual reading of capsule endoscopy (CE) videos in small bowel disease diagnosis is time-intensive. Algorithms introduced to automate this process are premature for real clinical applications, and multi-diagnosis using these methods has not been sufficiently validated. Therefore, we developed a practical binary classification model, which selectively identifies clinically meaningful images including inflamed mucosa, atypical vascularity or bleeding, and tested it with unseen cases. Four hundred thousand CE images were randomly selected from 84 cases in which 240,000 images were used to train the algorithm to categorize images binarily. The remaining images were utilized for validation and internal testing. The algorithm was externally tested with 256,591 unseen images. The diagnostic accuracy of the trained model applied to the validation set was 98.067%. In contrast, the accuracy of the model when applied to a dataset provided by an independent hospital that did not participate during training was 85.470%. The area under the curve (AUC) was 0.922. Our model showed excellent internal test results, and the misreadings were slightly increased when the model was tested in unseen external cases while the classified ‘insignificant’ images contain ambiguous substances. Once this limitation is solved, the proposed CNN-based binary classification will be a promising candidate for developing clinically-ready computer-aided reading methods.
- Published
- 2021
23. Expression profile of CD98 heavy chain and L-type amino acid transporter 1 and its prognostic significance in colorectal cancer
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Bogun Jang, Won Young Jang, Hyun Joo Song, Cheol Lee, Heung Up Kim, Hye Sung Kim, Do Yeon Kim, Donghyoun Lee, and Hye Min Chun
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Male ,Fusion Regulatory Protein 1, Heavy Chain ,Colorectal cancer ,Wnt signaling pathway ,Cell Biology ,Biology ,Middle Aged ,medicine.disease ,Stem cell marker ,Prognosis ,Survival Analysis ,digestive system diseases ,Pathology and Forensic Medicine ,Large Neutral Amino Acid-Transporter 1 ,Gene Expression Regulation, Neoplastic ,Hyperplastic Polyp ,Cancer stem cell ,Cancer research ,medicine ,AXIN2 ,Immunohistochemistry ,Humans ,Female ,Amino acid transporter ,Colorectal Neoplasms - Abstract
L-type amino acid transporter (LAT1) is a neutral amino acid transporter, forming a heterodimer complex with the CD98 heavy chain (CD98hc). In this study, we studied the expression profiles of LAT1 and CD98hc in colorectal cancer (CRC) and its precursor lesions. Transcription levels of CD98hc and LAT1 were significantly increased in CRC compared to the matched normal mucosa. CD98hc and LAT1 expression showed no significant correlations with cancer stem cell markers and intestinal stem cell markers, whereas both had positive correlations with Wnt target genes, AXIN2, and EPHB2, suggesting an association with aberrant Wnt signaling activation. Immunohistochemical analysis revealed that CD98hc and LAT1 are not expressed in normal colonic mucosa and various benign lesions including hyperplastic polyps and sessile and traditional serrated adenomas. CD98hc and LAT1 expressions began to appear in tubular adenomas and further increased in carcinomas. Of interest, CD98hc expression decreased during lymph node metastasis. Survival analysis demonstrated that CD98hc and LAT1 have no significant prognostic effect in CRCs. In conclusion, CD98hc and LAT1 are not normally expressed in colonic mucosa and most benign lesions. Their expression began to appear in tubular adenomas and further increased during the adenoma-to-carcinoma transition. CD98hc expression decreased while metastasizing to regional lymph nodes. However, CD98hc and LAT1 expressions had no prognostic value in patients with CRC.
- Published
- 2021
24. [SARS-CoV-2 Vaccination for Adult Patients with Inflammatory Bowel Disease: Expert Consensus Statements by KASID]
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Seong Eun Kim, Ji Young Chang, Byung Chang Kim, Yoo Jin Lee, Young Joo Yang, Hyun Joo Song, Duk Hwan Kim, Seung-Jae Myung, Yong Eun Park, Miyoung Choi, Jae Gon Lee, and Hee Chan Yang
- Subjects
Adult ,medicine.medical_specialty ,COVID-19 Vaccines ,Consensus ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Guidelines as Topic ,medicine.disease_cause ,Inflammatory bowel disease ,Immunocompromised Host ,medicine ,Global health ,Humans ,Intensive care medicine ,Societies, Medical ,Coronavirus ,business.industry ,SARS-CoV-2 ,Vaccination ,Gastroenterology ,Expert consensus ,COVID-19 ,General Medicine ,medicine.disease ,Inflammatory Bowel Diseases ,Clinical trial ,business - Abstract
Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, is threatening global health worldwide with unprecedented contagiousness and severity. The best strategy to overcome COVID-19 is a vaccine. Various vaccines are currently being developed, and mass vaccination is in progress. Despite the very encouraging clinical trial results of these vaccines, there is insufficient information on the safety and efficacy of vaccines for inflammatory bowel disease (IBD) patients facing various issues. After reviewing current evidence and international guidelines, the Korean Association for the Study of Intestinal Diseases (KASID) developed an expert consensus statement on COVID-19 vaccination issues for Korean IBD patients. This expert consensus statement emphasizes that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination be strongly recommended for IBD patients, and it is safe for IBD patients receiving immunomodulatory therapy.
- Published
- 2021
25. The Intestinal Stem Cell Marker SMOC2 Is an Independent Prognostic Marker Associated With Better Survival in Gastric Cancer
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Bogun Jang, Hye Sung Kim, Dong Hui Lee, Heung Up Kim, Sung Joon Park, Young Hee Maeng, Chang Lim Hyun, Hyun Joo Song, Young Sil Kim, and Cheol Lee
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Male ,Cancer Research ,medicine.medical_specialty ,Perineural invasion ,Stem cell marker ,Gastroenterology ,Stomach Neoplasms ,Internal medicine ,medicine ,Biomarkers, Tumor ,Humans ,Intestinal Mucosa ,Survival analysis ,Aged ,Neoplasm Staging ,Retrospective Studies ,Tissue microarray ,biology ,business.industry ,CD44 ,Calcium-Binding Proteins ,Cancer ,Intestinal metaplasia ,General Medicine ,Cell cycle ,medicine.disease ,Prognosis ,Intestines ,Survival Rate ,Oncology ,biology.protein ,Neoplastic Stem Cells ,Female ,business - Abstract
BACKGROUND/AIM SPARC-related modular calcium-binding protein 2 (SMOC2), a secreted matricellular protein, is reported to be involved in cancer progression such as cell cycle, angiogenesis, and invasion. In this study, we aimed to investigate the expression of SMOC2 in various gastric lesions and assessed its prognostic value in a large cohort of gastric cancer (GC) patients. PATIENTS AND METHODS SMOC2 mRNA levels were measured by quantitative real-time PCR using 26 matched fresh-frozen GC samples. SMOC2 protein expression was determined by immunohistochemistry on tissue microarrays including 734 GC specimens and its correlations with clinicopathological features and survival were evaluated. RESULTS The transcription level of SMOC2 was higher in GC samples compared to normal mucosa (p=0.006). Its expression levels were associated with the intestinal stem cell (ISC) marker, LGR5, but there were no correlations with EPHB2 and OLFM4 or the candidate cancer stem cell markers CD133 and CD44. SMOC2 expression was significantly increased in the intestinal metaplasia and was further increased in gastric adenomas and early gastric cancers (EGC). In total, 34% of GCs were positive for SMOC2, and SMOC2 positivity was higher in old (p=0.001) and male (p
- Published
- 2021
26. Long Lasting Mesalazine-induced Pancytopenia in a Patient with Ulcerative Colitis
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Chiyoon Moon, Sanghoon Han, Juyeon Ko, and Hyun Joo Song
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Long lasting ,chemistry.chemical_compound ,medicine.medical_specialty ,Mesalazine ,chemistry ,business.industry ,Internal medicine ,medicine ,medicine.disease ,business ,Ulcerative colitis ,Gastroenterology ,Pancytopenia - Published
- 2019
27. The Effect of facial emotion Recognition of Real-face Expression and Emoticons on Interpersonal Competence: Mobile Application Based research for Middle School Students
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Hyun Joo Song and Myeong Jie Yeem
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Facial expression ,Interpersonal competence ,General Earth and Planetary Sciences ,Emoticon ,Emotion recognition ,Psychology ,General Environmental Science ,Cognitive psychology - Published
- 2019
28. Infants’ social evaluations of helping behaviors
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Hyun Joo Song and Park Chaerin
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Psychology - Published
- 2019
29. The relationships between autistic trait and socio-moral judgments
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Minjung Cha, Hyun Joo Song, and Kyong-sun Jin
- Subjects
media_common.quotation_subject ,medicine ,Trait ,Autism ,Psychology ,medicine.disease ,Morality ,media_common ,Developmental psychology - Published
- 2019
30. Topographical plots of esophageal distension and contraction: effects of posture on esophageal peristalsis and bolus transport
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Young Hoon Youn, Ali Zifan, Xinhuan Qiu, Hyun Joo Song, Ravinder K. Mittal, and Melissa M. Ledgerwood-Lee
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Adult ,Male ,medicine.medical_specialty ,Contraction (grammar) ,Manometry ,Physiology ,Posture ,Distension ,Patient Positioning ,Esophagus ,Bolus (medicine) ,Digestive System Physiological Phenomena ,Physiology (medical) ,Internal medicine ,Electric Impedance ,medicine ,Humans ,Peristalsis ,Hepatology ,business.industry ,Gastroenterology ,Deglutition ,Cardiology ,Female ,Esophageal peristalsis ,business ,Muscle Contraction ,Research Article - Abstract
Each swallow induces a wave of inhibition followed by contraction in the esophagus. Unlike contraction, which can easily be measured in humans using high-resolution manometry (HRM), inhibition is difficult to measure. Luminal distension is a surrogate of the esophageal inhibition. The aim of this study was to determine the effect of posture on the temporal and quantitative relationship between distension and contraction along the entire length of the esophagus in normal healthy subjects by using concurrent HRM, HRM impedance (HRMZ), and intraluminal ultrasound (US). Studies were conducted in 15 normal healthy subjects in the supine and Trendelenburg positions. Both manual and automated methods were used to extract quantitative pressure and impedance-derived features from the HRMZ recordings. Topographical plots of distension and contraction were visualized along the entire length of the esophagus. Distension was also measured from the US images during 10-ml swallows at 5 cm above the lower esophageal sphincter. Each swallow was associated with luminal distension followed by contraction, both of which traversed the esophagus in a sequential/peristaltic fashion. Luminal distension (US) and esophageal contraction amplitude were greater in the Trendelenburg compared with the supine position. Length of esophageal breaks (in the transition zone) were reduced in the Trendelenburg position. Change in posture altered the temporal relationship between distension and contraction, and bolus traveled closer to the esophageal contraction in the Trendelenburg position. Topographical contraction-distension plots derived from HRMZ recordings is a novel way to visualize esophageal peristalsis. Future studies should investigate if abnormalities of esophageal distension are the cause of functional dysphagia. NEW & NOTEWORTHY Ascending contraction and descending inhibition are two important components of peristalsis. High-resolution manometry only measures the contraction phase of peristalsis. We measured esophageal distension from intraluminal impedance recordings and developed novel contraction-distension topographical plots to prove that similar to contraction, distension also travels in a peristaltic fashion. Change in posture from the supine to the Trendelenburg position also increased the amplitude of esophageal distension and contraction and altered the temporal relationship between distension and contraction.
- Published
- 2019
31. Children’s moral evaluations of lying for one’s ingroup member
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Kyong-sun Jin and Hyun Joo Song
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Psychology ,Ingroups and outgroups ,Social psychology ,Lying - Published
- 2019
32. Drawing attention to recipients’ emotional and physical characteristics promotes generous resource allocations in preschoolers
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Hyun Joo Song, Jewan Park, and Park Chaerin
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Public economics ,Psychology - Published
- 2019
33. Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study
- Author
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Jin-Won Kwon, Hyun Joo Song, Kyung Sik Park, Hyun Jin Kim, Nayoung Kim, Gwang Ho Baik, Jeong Eun Shin, Ju Yup Lee, Suck Chei Choi, Seon Hee Lim, Joo Sung Kim, Joo Hyun Lim, Jeong Yoon Yim, Dae Seong Myung, and Sung Eun Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Physiology ,Population ,Comorbidity ,Helicobacter Infections ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Republic of Korea ,Prevalence ,Humans ,Medicine ,Prospective Studies ,education ,National Cholesterol Education Program ,Aged ,Metabolic Syndrome ,education.field_of_study ,Helicobacter pylori ,medicine.diagnostic_test ,biology ,business.industry ,Age Factors ,Gastroenterology ,Middle Aged ,Hepatology ,medicine.disease ,biology.organism_classification ,Cross-Sectional Studies ,Socioeconomic Factors ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Metabolic syndrome ,business ,Lipid profile ,Body mass index - Abstract
Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P
- Published
- 2019
34. The Influence of Foreign Language Experiences on Children’s Language Development: A Review and Suggestions for Future Research
- Author
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Hyun Joo Song
- Subjects
Language development ,Foreign language ,Pedagogy ,Psychology - Published
- 2019
35. Development and Verification of a Deep Learning Algorithm to Evaluate Small-Bowel Preparation Quality
- Author
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Yun Jeong Lim, Hyun Joo Song, Dong Jun Oh, Sumin Lee, and Ji Hyung Nam
- Subjects
Medicine (General) ,Scoring system ,Computer science ,media_common.quotation_subject ,Clinical Biochemistry ,capsule endoscopy ,Article ,law.invention ,03 medical and health sciences ,R5-920 ,0302 clinical medicine ,Adequate preparation ,Capsule endoscopy ,law ,Quality (business) ,media_common ,quality of bowel preparation ,deep learning algorithm ,validation ,Receiver operating characteristic ,business.industry ,Deep learning ,030220 oncology & carcinogenesis ,Bowel preparation ,030211 gastroenterology & hepatology ,Artificial intelligence ,business ,Algorithm ,Kappa - Abstract
Capsule endoscopy (CE) quality control requires an objective scoring system to evaluate the preparation of the small bowel (SB). We propose a deep learning algorithm to calculate SB cleansing scores and verify the algorithm’s performance. A 5-point scoring system based on clarity of mucosal visualization was used to develop the deep learning algorithm (400,000 frames; 280,000 for training and 120,000 for testing). External validation was performed using additional CE cases (n = 50), and average cleansing scores (1.0 to 5.0) calculated using the algorithm were compared to clinical grades (A to C) assigned by clinicians. Test results obtained using 120,000 frames exhibited 93% accuracy. The separate CE case exhibited substantial agreement between the deep learning algorithm scores and clinicians’ assessments (Cohen’s kappa: 0.672). In the external validation, the cleansing score decreased with worsening clinical grade (scores of 3.9, 3.2, and 2.5 for grades A, B, and C, respectively, p < 0.001). Receiver operating characteristic curve analysis revealed that a cleansing score cut-off of 2.95 indicated clinically adequate preparation. This algorithm provides an objective and automated cleansing score for evaluating SB preparation for CE. The results of this study will serve as clinical evidence supporting the practical use of deep learning algorithms for evaluating SB preparation quality.
- Published
- 2021
36. Consistency of Helicobacter pylori eradication rates of first‐line concomitant and sequential therapies in Korea: A nationwide multicenter retrospective study for the last 10 years
- Author
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Joon Sung Kim, Nayoung Kim, Hyun Joo Song, Jie Hyun Kim, Jin Il Kim, Ju Yup Lee, Seon-Young Park, Ji Hyun Kim, Bong Eun Lee, Byung-Wook Kim, Ki Bae Kim, Seong Woo Jeon, Jeong Hoon Lee, Moon Kyung Joo, Jun-Won Chung, Seung Young Seo, Hyun Jin Kim, Chang Seok Bang, and Sung Eun Kim
- Subjects
Adult ,medicine.medical_specialty ,First line ,macromolecular substances ,Helicobacter Infections ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Republic of Korea ,Concomitant Therapy ,Humans ,Medicine ,Retrospective Studies ,Helicobacter pylori ,biology ,business.industry ,Gastroenterology ,Amoxicillin ,Proton Pump Inhibitors ,Retrospective cohort study ,General Medicine ,biology.organism_classification ,Anti-Bacterial Agents ,Regimen ,Infectious Diseases ,030220 oncology & carcinogenesis ,Concomitant ,Drug Therapy, Combination ,030211 gastroenterology & hepatology ,business - Abstract
BACKGROUND Eradication rate of standard triple therapy for H. pylori has declined to unacceptable level, and alternative regimens such as concomitant and sequential therapy have been introduced. We aimed to assess the consistency of eradication rates of concomitant and sequential therapies as for the first-line H. pylori eradication in Korea. METHODS A nationwide multicenter retrospective study was conducted including 18 medical centers from January 2008 to December 2017. We included 3,800 adults who had test to confirm H. pylori eradication within 1 year after concomitant or sequential therapy. RESULTS Concomitant and sequential therapy were prescribed for 2508 and 1292 patients, respectively. The overall eradication rate of concomitant therapy was significantly higher than that of sequential therapy (91.8% vs. 86.1%, p
- Published
- 2021
37. Disentangling language status and country-of-origin explanations of the bilingual advantage in preschoolers
- Author
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J. Bruce Morton, Jewan Park, Hyun-joo Song, and Isu Cho
- Subjects
Language status ,Canada ,Bilingual advantage ,Culture ,050109 social psychology ,Experimental and Cognitive Psychology ,Multilingualism ,Developmental psychology ,Executive Function ,Inhibitory control ,Republic of Korea ,Developmental and Educational Psychology ,Cultural values ,Humans ,0501 psychology and cognitive sciences ,East Asia ,Child ,Language ,4. Education ,05 social sciences ,Country of origin ,Psychology ,Executive functioning ,050104 developmental & child psychology - Abstract
Bilingual preschoolers from East Asia outperform monolingual preschoolers from North America or Europe in executive functioning tasks, which has been interpreted as evidence of a bilingual advantage in executive functioning. This study tested whether these differences actually reflect country-of-origin effects given that East Asian preschoolers frequently outperform North American or European children in executive functioning tasks. Consistent with previous findings, Korean-English bilingual preschoolers made fewer errors in an age-appropriate executive functioning task than did English monolingual children in Canada. However, Korean-English bilingual preschoolers performed comparably to Korean monolingual preschoolers in Korea. Differences between Korean and Canadian children's executive functioning were not attributable to differences in parental cultural values or attitudes. The current findings suggest that differences between East Asian bilingual and North American monolingual preschoolers' executive functioning is related to differences in country of origin rather than language status.
- Published
- 2021
38. Expression profile of intestinal stem cell and cancer stem cell markers in gastric cancers with submucosal invasion
- Author
-
Heung Up Kim, Jung Hyub Shin, Hyun Joo Song, Hye Sung Kim, Hyun Min Koh, Bo Gun Jang, and In Ho Jeong
- Subjects
0301 basic medicine ,Adult ,Male ,Receptor, EphB2 ,Biology ,Stem cell marker ,Pathology and Forensic Medicine ,Metastasis ,Receptors, G-Protein-Coupled ,03 medical and health sciences ,0302 clinical medicine ,Cancer stem cell ,Cell Movement ,Stomach Neoplasms ,Cell Line, Tumor ,medicine ,Biomarkers, Tumor ,Humans ,Neoplasm Invasiveness ,Intestinal Mucosa ,Aged ,Retrospective Studies ,Aged, 80 and over ,Lamina propria ,CD44 ,LGR5 ,Cancer ,Cell Biology ,Middle Aged ,medicine.disease ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Lymphatic Metastasis ,biology.protein ,Cancer research ,Neoplastic Stem Cells ,Intercellular Signaling Peptides and Proteins ,Female ,Stem cell ,Transcriptome ,Signal Transduction - Abstract
Cancer stem cells (CSCs) are believed to be responsible for tumor growth, invasion, and metastasis. Submucosal invasion, which greatly enhances metastasis risk, is a critical step in gastric cancer (GC) progression. To identify stem cell-related markers associated with submucosal invasion and lymph node (LN) metastasis in GCs, we investigated the expression of candidate CSC markers (CD133, CD44, and ALDH1A) and intestinal stem cell (ISC) markers (EPHB2, OLFM4, and LGR5) in early GCs that manifested submucosal invasion. We discovered that EPHB2 and LGR5 expression was frequently confined to the basal area of the lamina propria (basal pattern) in mucosal cancer, and the proportion of stem cell marker-positive cells substantially increased during submucosal invasion. CD44 expression showed a focal pattern, ALDH1A was predominantly expressed diffusely, and there was no expansion of CD44 or ALDH1A expression in the submucosal cancer cells. Unexpectedly, no CSC markers showed any associations with LN metastasis, and only loss of EPHB2 expression was associated with increased LN metastasis. Treatment of RSPO2, a niche factor, along with Wnt 3a, to GC cells led to increased EPHB2 and LGR5 mRNA levels. RNA in situ hybridization confirmed specific RSPO2 expression in the smooth muscle cells of the muscularis mucosa, suggesting that RSPO2 is responsible for the increased expression of ISC markers in GC cells at the basal areas. In summary, no stem cell markers were associated with increased LN metastasis in early GCs. Conversely, isolated EPHB2 expression was associated with lower LN metastasis. EPHB2 and LGR5 showed a basal distribution pattern along with enhanced expression in submucosal invading cells in early GCs, which was induced by a niche factor, RSPO2, from the muscularis mucosa.
- Published
- 2020
39. Older adults consider others' intentions less but allocentric outcomes more than young adults during an ultimatum game
- Author
-
Hackjin Kim, Isu Cho, Sunhae Sul, and Hyun-joo Song
- Subjects
Adult ,Aged, 80 and over ,Male ,Aging ,Social Psychology ,Ultimatum game ,Decision Making ,Age Factors ,PsycINFO ,Middle Aged ,Outcome (game theory) ,Preference ,Developmental psychology ,Young Adult ,Prosocial behavior ,Games, Recreational ,Theory of mind ,Humans ,Female ,Elderly adults ,Geriatrics and Gerontology ,Young adult ,Psychology ,Social Behavior ,Aged - Abstract
The present research investigated age-related differences in other-regarding preferences-the preference for taking others' benefit into account during social decision-making-between young and elderly adults. Young and older Korean adults responded to multiple rounds of a mini-ultimatum game, and the extent to which each individual considered outcome and intention was quantified using economic utility models. We found that older adults, compared to young adults, were less likely to consider others' intentions, while focusing more on others' outcomes. Possible psychological factors underlying our findings, including theory of mind, prosocial values, and decision strategies, are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
- Published
- 2020
40. Expression of Intestinal Stem Cell and Cancer Stem Cell Markers in Submucosal Invasion and Its Prognostic Significance in Gastric Cancers
- Author
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Hye Sung Kim, Bo Gun Jang, Hyun Joo Song, and In Ho Jeong
- Subjects
Cancer stem cell ,Cancer research ,pathology_pathobiology ,Stem cell ,Biology ,digestive system - Abstract
Submucosal invasion is a critical step in gastric cancer (GC) progression, which greatly enhances metastasis risk. Cancer stem cells are responsible for invasion, metastasis, and tumor growth. To identify stem cell-related markers associated with submucosal invasion in GCs, we investigated the expression of candidate cancer stem cell (CSC) markers (CD133, CD44, and ALDH1A) and intestinal stem cell (ISC) markers (EPHB2, OLFM4, and LGR5) in early GCs with submucosal invasion. Remarkably, expression of all ISC markers and CD133 was frequently confined to the basal area of the lamina propria (basal pattern) in mucosal cancer. The proportion of stem cell marker-positive cells substantially increased during submucosal invasion. Given that ISC markers are restricted to the crypt base of the normal intestinal mucosa, these findings suggest that many early GCs may retain hierarchical characteristics. CD44 expression showed a focal pattern, ALDH1A was predominantly expressed diffusely, and there was no expansion of CD44 or ALDH1A expression in the submucosal cancer cells. RSPO2 from muscularis mucosa seem to be partly responsible for the increased expression of ISC markers in GC cells at the basal areas. We also found that ISC markers were correlated with CDX2 expression in GCs, indicating that ISC markers are involved in the intestinal differentiation in GCs. Interestingly, ISC markers (EPHB2 and OLFM4) and CD133 showed a positive impact on clinical outcomes. In particular, the prognostic value of EPHB2 was significant for intestinal-type GCs in a multivariate analysis. In summary, ISC markers and CD133 showed a basal distribution pattern along with enhanced expression in submucosal invading cells in early GCs. EPHB2 was an independent prognostic marker in intestinal-type GCs.
- Published
- 2020
41. ARTIFICIAL INTELLIGENCE, TRAINED WITH A ROUGH BINARY CLASSIFICATION, CAN SELECT SIGNIFICANT IMAGES OF CAPSULE ENDOSCOPY
- Author
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Dong Jun Oh, Hyun Joo Song, Jong-Sook Park, Youngbae Hwang, Min Kyu Jung, Yun Jeong Lim, Sang-Hyun Kim, Ji Hyung Nam, and Ki Bae Kim
- Subjects
Binary classification ,business.industry ,Capsule endoscopy ,law ,Computer science ,Pattern recognition ,Artificial intelligence ,business ,law.invention - Published
- 2020
42. Comparison of subjective quality of life after endoscopic submucosal resection or surgery for early gastric cancer
- Author
-
Ki Nam Shim, Yong Sung Kim, Byung-Wook Kim, Seung Ho Jang, Su Jin Hong, Hyun Joo Song, Jie Hyun Kim, Chung Hyun Tae, Gwang Ho Baik, and Hye Kyung Jung
- Subjects
Male ,medicine.medical_specialty ,Endoscopic Mucosal Resection ,Psychometrics ,Health Status ,lcsh:Medicine ,Article ,Resection ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Stomach Neoplasms ,medicine ,Subtotal gastrectomy ,Humans ,Subjective quality ,lcsh:Science ,Cancer ,Multidisciplinary ,business.industry ,Confounding ,lcsh:R ,Gastroenterology ,Middle Aged ,medicine.disease ,humanities ,Early Gastric Cancer ,Surgery ,Socioeconomic Factors ,030220 oncology & carcinogenesis ,Quality of Life ,030211 gastroenterology & hepatology ,lcsh:Q ,Female ,business ,After treatment - Abstract
Quality of life (QoL) has become an important issue after early gastric cancer (EGC) treatment. We aimed to compare the QoL of EGC survivors after ESD (n = 241) or laparoscopic subtotal gastrectomy (n = 241) without recurrence and to evaluate the QoL over the 5-year period after adjusting for various confounding factors related to QoL. QoL related to the gastric cancer subscale (GCS) was significantly higher in the ESD group than surgery group (p p = 0.983). Therefore, we concluded that EGC survivors who undergo ESD have significantly better QoL related to GCS over a 5-year period after treatment than those who undergo surgery. This may be a useful consideration when selecting treatment modalities for patients with EGC.
- Published
- 2020
43. Validation of a mobile game-based assessment of cognitive control among children and adolescents
- Author
-
Hae-Jeong Park, Do-Joon Yi, and Hyun-Joo Song
- Subjects
Male ,020205 medical informatics ,Social Sciences ,02 engineering and technology ,Adolescents ,Families ,Executive Function ,Cognition ,Learning and Memory ,0302 clinical medicine ,Medicine and Health Sciences ,0202 electrical engineering, electronic engineering, information engineering ,Psychology ,030212 general & internal medicine ,Child ,Children ,Multidisciplinary ,Cognitive Neurology ,Neuropsychology ,Mobile Applications ,Neurology ,Medicine ,Female ,Games ,Research Article ,Clinical psychology ,Adolescent ,Cognitive Neuroscience ,Science ,Control (management) ,MEDLINE ,Sample (statistics) ,03 medical and health sciences ,Memory ,Humans ,Working Memory ,Neuropsychological Testing ,Behavior ,Working memory ,Biology and Life Sciences ,Clinical trial ,Video Games ,Age Groups ,People and Places ,Cognitive Science ,Recreation ,Population Groupings ,Neuroscience ,Stroop effect - Abstract
Cognitive control is the most fundamental psychological function that underlies the execution of many other psychological functions. A mobile game application could be a useful strategy to evaluate cognitive control in the groups of children and adolescents. Although a serious game that is based on gamification would be an optimal platform for the administration of behavioral and clinical assessments of children and adolescents, most studies on gamification have been conducted among adults and older adults than among children and adolescents. This study aimed to assess cognitive control using a mobile game that used gamification and compared the results to those from traditional neuropsychological tests for children and adolescents. In order to address this objective, this study used a serious game, namely, "CoCon," which was developed to assess cognitive control in children and adolescents. This study included 100 participants from a community sample (mean age = 11.75 years, ranged from 9 to 16 years, SD = 1.40 years; Male = 59(59%), Female = 41(41%)). The analyses interrogated the relationships among various game behaviors scores of CoCon, the standardized neuropsychological tests (K-WISC-IV, CTT, and Stroop), and self-reporting executive function difficulty questionnaire. As results, a mobile game application-based assessment proved to be a reliable and valid measure of the cognitive control in children and adolescents. The index scores from the CoCon were significantly related to various cognitive control functions and differentiated between the high and low cognitive control groups. Specifically, even though the participants completed the mobile game 'CoCon' in their natural habitats, the CoCon scores were comparable to the measures from standard neuropsychological tests. In conclusion, the present findings suggest that mobile games that use advanced technology and sophisticated psychological strategies can serve as a new and expanded platform for the administration of psychological assessments.
- Published
- 2020
44. Fourteen- to Eighteen-Month-Old Infants Use Explicit Linguistic Information to Update an Agent’s False Belief
- Author
-
Hyun Joo Song, Yoon Hee Kim, H. C. Lee, Yu Jin Kim, Minjung Cha, Kyong-sun Jin, Yoon-ha Lee, and Miri Song
- Subjects
genetic structures ,lcsh:BF1-990 ,Psychology of reasoning ,false-belief understanding ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Rule-based machine translation ,verbal information ,Psychology ,0501 psychology and cognitive sciences ,infancy ,General Psychology ,Original Research ,theory of mind ,False belief ,05 social sciences ,psychological reasoning ,lcsh:Psychology ,Ball (bearing) ,sense organs ,human activities ,030217 neurology & neurosurgery ,Cognitive psychology ,cognitive development - Abstract
The current research examined how infants exploit linguistic information to update an agent's false belief about an object's location. Fourteen- to eighteen-month-old infants first watched a series of events involving two agents, a ball, and two containers (a box and a cup). Agent1 repeatedly acted on the ball and then put it in the box in the presence of agent2. Then agent1 disappeared from the scene and agent2 switched the ball's location from the box to the cup. Upon agent1's return, agent2 told her, "The ball is in the cup!" Agent1 then reached for either the cup (cup event) or the box (box event). The infants looked reliably longer if shown the box event as opposed to the cup event. However, when agent2 simply said, "The ball and the cup!" - which does not explicitly mention the ball's new location - infants looked significantly longer if shown the cup event as opposed the box event. These findings thus provide new evidence for false-belief understanding in infancy and suggest that infants expect an agent's false belief to be updated only by explicit verbal information.
- Published
- 2019
45. Negativity bias in infants’ expectations about agents’ dispositions
- Author
-
Joanna Joo Kyung Chae and Hyun Joo Song
- Subjects
Male ,05 social sciences ,Infant ,Choice Behavior ,Moral Development ,050105 experimental psychology ,Child Development ,Social Perception ,Developmental Neuroscience ,Moral development ,Social cognition ,Negativity bias ,Developmental and Educational Psychology ,Humans ,Female ,Interpersonal Relations ,0501 psychology and cognitive sciences ,Test phase ,Valence (psychology) ,Social Behavior ,Psychology ,050104 developmental & child psychology ,Cognitive psychology ,Social evaluation - Abstract
This study investigated 6- and 10-month-old infants' abilities to infer others' preferences based on social interactions using looking time and choice measures. Infants were randomly assigned to either a helping/neutral or hindering/neutral condition. Those in the helping/neutral condition were first familiarized with a helping event, in which an agent helped a circle climb a hill, and a neutral event, in which another agent followed the same path as the helping agent but had no interaction with the circle. During the test phase, the circle approached either the helper or the neutral agent. In the hindering/neutral condition, the infants were familiarized with a hindering event, in which an agent hindered the circle from reaching the top of the hill, and a neutral event, in which another agent followed the same path as the hindering agent but had no interaction with the circle. During the test phase, the circle approached either the hinderer or the neutral agent. For the looking-time measure, infants in the hindering/neutral condition looked reliably longer at the approach-hinderer than at the approach-neutral agent event, whereas those in the helping/neutral condition looked for equal amounts of time at both test events. These results suggest that the infants expected the circle to avoid the hinderer but did not expect it to approach the helper. In the choice task, infants chose the helper more often than the neutral agent and the neutral agent more often than the hinderer, suggesting an ability to generate their own preferences for a particular agent based on the valence of helping and hindering actions. This research demonstrates infants' sensitivity to the moral valence of agents' social interactions, which may serve as a foundation for advanced socio-moral reasoning. Statement of contribution What is already known on this subject? Research on infants' ability in social evaluation has established that even preverbal infants can distinguish between positive and negative social interactions. Infants as young as 6 months of age can distinguish between helping and hindering actions and can generate their own preference towards helpful agents. What does this study add? The present study sheds light on infants' ability to infer a third-party's preference, which is a more challenging task for the infants than generating their own preference. Specifically, 6- and 10-month-old infants could infer others' preference for the neutral agent over the hinderer. Such results demonstrate infants' sensitivity to the moral valence of agents' social interactions and provide an evidence of negativity bias in social evaluation.
- Published
- 2018
46. Why We Do and What We Do : The Experience of Good English Language Learners
- Author
-
Hee Kyung Lee, Rosa Oh, Hyun-Kyu Choi, Hyun Joo Song, H. C. Lee, Myung Hwan Hwang, Youn Mi Cathy Lee, and Sue Jeong Shin
- Subjects
Linguistics and Language ,Language learning strategies ,Active learning ,Mathematics education ,Metacognition ,Cognition ,Language proficiency ,Context (language use) ,Psychology ,Memorization ,Education ,Narrative inquiry - Abstract
This narrative inquiry explores how good English language learners’ (GELLs) L2 motivation and usage of language learning strategies change over time based on the onset age of active English learning in the Korean English as a foreign language (EFL) context. And also the current study examines how GELLs learn English. The authors investigated a total dataset of 83 GELLs from 25 autobiographical books on “How I succeed in learning English as a foreign language.” Results indicated that as GELLs’ language proficiency increased, their L2 motivation changed in different patterns depending on the onset age of active English learning. Second, GELLs preferred metacognitive, cognitive, memorization, and social strategies both at the beginning and advanced stage of the English learning process regardless of the onset age of active learning. Finally, GELLs acquired English through a well-balanced language course regardless of the onset age of active learning. Pedagogical implications and future research suggestions are also discussed.
- Published
- 2018
47. In Vivo Endoscopic Removal of Ancylostoma duodenale in a Patient with Abdominal Pain
- Author
-
Seung Uk Jeong, Byung-Cheol Song, Heung Up Kim, Sun Jin Boo, Hyun Joo Song, Eun Kwang Choi, Young Ree Kim, and Soo Young Na
- Subjects
medicine.medical_specialty ,Abdominal pain ,Hookworm ,lcsh:Internal medicine ,Ancylostoma ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Internal medicine ,parasitic diseases ,medicine ,030212 general & internal medicine ,lcsh:RC31-1245 ,medicine.diagnostic_test ,biology ,business.industry ,Endoscopy ,biology.organism_classification ,Parasitic diseases ,Ancylostoma duodenale ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
A 20-year-old Cambodian male living in Korea for 2 years as a foreign worker visited our gastroenterology outpatient clinic. He had a small farm in Cambodia. He complained of postprandial upper abdominal pain with nausea and vomiting for 2 years. Gastroduodenoscopy showed hyperemic mucosa near the major papilla in the duodenum and two small and slender reddish worms. These were removed with endoscopic biopsy forceps. Under microscopy, these were identified as Ancylostoma duodenale by the characteristic morphology of 2 pairs of cutting teeth in the buccal cavity and 3 lobes in the copulatory bursa. After removal of two worms, his symptom improved. Soil-transmitted helminths (STH) present a global health problem. In the Republic of Korea, STH, including hookworms, were highly prevalent until the 1970s. With mass fecal examination followed by selective mass chemotherapy with anthelmintics from 1969 to 1995, the prevalence of STH has rapidly decreased since the 1980s. Since 2004, no hookworms have been found in nationwide surveys on the prevalence of intestinal parasitic infection. Therefore, we report a case of in vivo endoscopic removal of A. duodenale in a patient with abdominal pain.
- Published
- 2018
48. Differential structure-function network coupling in the inattentive and combined types of attention deficit hyperactivity disorder
- Author
-
Hae-Jeong Park, Hyun-Joo Song, Elizabeth Quattrocki Knight, Saebyul Lee, Chongwon Pae, Sol Yoo, and Dongha Lee
- Subjects
Male ,Social Sciences ,Diagnostic Radiology ,Correlation ,Families ,Cognition ,Medical Conditions ,Functional Magnetic Resonance Imaging ,Medicine and Health Sciences ,Psychology ,Child ,Children ,Default mode network ,Brain Mapping ,Multidisciplinary ,medicine.diagnostic_test ,Radiology and Imaging ,Cognitive flexibility ,Magnetic Resonance Imaging ,Neurology ,Medicine ,Female ,Network Analysis ,Research Article ,Computer and Information Sciences ,Neural Networks ,Imaging Techniques ,Science ,Neuropsychiatric Disorders ,Neuroimaging ,Research and Analysis Methods ,behavioral disciplines and activities ,Developmental Neuroscience ,Diagnostic Medicine ,Salience (neuroscience) ,Mental Health and Psychiatry ,mental disorders ,Connectome ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Behavior ,Biology and Life Sciences ,medicine.disease ,Attention Deficit Disorder with Hyperactivity ,Neurodevelopmental Disorders ,Age Groups ,People and Places ,Adhd ,Population Groupings ,Functional magnetic resonance imaging ,Neuroscience - Abstract
The heterogeneous presentation of inattentive and hyperactive-impulsive core symptoms in attention deficit hyperactivity disorder (ADHD) warrants further investigation into brain network connectivity as a basis for subtype divisions in this prevalent disorder. With diffusion and resting-state functional magnetic resonance imaging data from the Healthy Brain Network database, we analyzed both structural and functional network efficiency and structure-functional network (SC-FC) coupling at the default mode (DMN), executive control (ECN), and salience (SAN) intrinsic networks in 201 children diagnosed with the inattentive subtype (ADHD-I), the combined subtype (ADHD-C), and typically developing children (TDC) to characterize ADHD symptoms relative to TDC and to test differences between ADHD subtypes. Relative to TDC, children with ADHD had lower structural connectivity and network efficiency in the DMN, without significant group differences in functional networks. Children with ADHD-C had higher SC-FC coupling, a finding consistent with diminished cognitive flexibility, for all subnetworks compared to TDC. The ADHD-C group also demonstrated increased SC-FC coupling in the DMN compared to the ADHD-I group. The correlation between SC-FC coupling and hyperactivity scores was negative in the ADHD-I, but not in the ADHD-C group. The current study suggests that ADHD-C and ADHD-I may differ with respect to their underlying neuronal connectivity and that the added dimensionality of hyperactivity may not explain this distinction.
- Published
- 2021
49. A Study on the Elements Analysis according for the Development Characteristics of the Augmented Reality Toy-Games
- Author
-
Hyun-Joo Song, Hae-Sun No, and Dae-Woong Rhee
- Published
- 2017
50. The Effects of Activated Moral Foundations On the Moral Judgments on Policy Issues
- Author
-
Hyun-Joo Song
- Subjects
General Medicine - Published
- 2017
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