Author: "Hull M" / Database: OpenAIRE - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Hull M"' showing total 46 results

Start Over Author "Hull M" Database OpenAIRE

46 results on '"Hull M"'

1. Distilling Missing Modality Knowledge from Ultrasound for Endometriosis Diagnosis with Magnetic Resonance Images

Author: Zhang, Yuan, Wang, Hu, Butler, David, To, Minh-Son, Avery, Jodie, Hull, M Louise, and Carneiro, Gustavo
Subjects: FOS: Computer and information sciences, Computer Science - Machine Learning, Computer Vision and Pattern Recognition (cs.CV), Image and Video Processing (eess.IV), FOS: Electrical engineering, electronic engineering, information engineering, Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing, Machine Learning (cs.LG)
Abstract: Endometriosis is a common chronic gynecological disorder that has many characteristics, including the pouch of Douglas (POD) obliteration, which can be diagnosed using Transvaginal gynecological ultrasound (TVUS) scans and magnetic resonance imaging (MRI). TVUS and MRI are complementary non-invasive endometriosis diagnosis imaging techniques, but patients are usually not scanned using both modalities and, it is generally more challenging to detect POD obliteration from MRI than TVUS. To mitigate this classification imbalance, we propose in this paper a knowledge distillation training algorithm to improve the POD obliteration detection from MRI by leveraging the detection results from unpaired TVUS data. More specifically, our algorithm pre-trains a teacher model to detect POD obliteration from TVUS data, and it also pre-trains a student model with 3D masked auto-encoder using a large amount of unlabelled pelvic 3D MRI volumes. Next, we distill the knowledge from the teacher TVUS POD obliteration detector to train the student MRI model by minimizing a regression loss that approximates the output of the student to the teacher using unpaired TVUS and MRI data. Experimental results on our endometriosis dataset containing TVUS and MRI data demonstrate the effectiveness of our method to improve the POD detection accuracy from MRI., This paper is accepted by 2023 IEEE 20th International Symposium on Biomedical Imaging(ISBI 2023)
Published: 2023

2. Predicting the Effect of Muscle Length on Fatigue during Electrically Stimulated Isometric Contractions

Author: Marion, S, Wexler, A, Hull, M, and Binder-Macleod, S
Published: 2022

3. Prospects for Fundamental Physics with LISA

Author: Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolás, Abdelsalhin, T., Achucarro, A., Aelst, K.V., Afshordi, N., Akcay, S., Annulli, L., Arun, K.G., Avendano, A.C., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Brügmann, B., Bulten, H., Buonanno, A., Burke, A.O., Burko, L.M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cárdenas-Avendaño, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compère, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., De Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Di Filippo, F., Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J.R., Emparan, R., Ezquiaga, J.M., Fairbairn, M., Fairhurst, S., Farmer, H.F., Fasiello, M.R., Ferrari, V., Ferreira, P.G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L.Á., Germani, C., Gerosa, D., Giddings, S.B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W.-B., Hawken, A.J., Hees, A., Heng, I.S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J.v., Hoyle, C.J.D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julié, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N.V., Kroon, J.A.V., Kunz, M., Lahav, O., Landragin, A., Lang, R.N., Le Poncin-Lafitte, C., Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F.S.N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R.P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C.J.A.P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N.E., Mazumdar, A., Meerburg, P.D., Megias, E., Miller, J., Mimoso, J.P., Mittnacht, L., Montero, M.M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novák, J., Nunes, N.J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J.J., Rubiera-García, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I.D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S.L., Shoemaker, D., Silva, A.D., Simpson, C., Sopuerta, C.F., Spallicci, A., Stefanek, B.A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A.L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C.S., Vagenas, E.C., Valageas, P., Vallisneri, M., Van Den Brand, J., Van Den Broeck, C., van de Meent, M., Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Völkel, S., Wang, Q., Wang, Yu-Tong, Werner, M.C., Westernacher, J., Weygaert, R.v.d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhão, M., Zimmerman, A., Zumalacarregui, M., Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Systèmes de Référence Temps Espace (SYRTE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), MESA+ Institute, Laser Physics & Nonlinear Optics, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National d’Études Spatiales [Paris] (CNES), European Commission, Royal Society (UK), National Aeronautics and Space Administration (US), National Science Foundation (US), Alfred P. Sloan Foundation, Science and Technology Facilities Council (UK), Barausse, E., Berti, E., Hertog, T., Hughes, S. A., Jetzer, P., Pani, P., Sotiriou, T. P., Tamanini, N., Witek, H., Yagi, K., Yunes, N., Abdelsalhin, T., Achucarro, A., van Aelst, K., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Brugmann, B., Bulten, H., Buonanno, A., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cardenas-Avendano, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compere, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Filippo, F. D., Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. A., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J., Hoyle, C. J. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julie, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. L., Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novak, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-Garcia, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. V., Broeck, C. V., de Meent, M., Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Volkel, S., Wang, Q., Wang, Y. -T., Werner, M. C., Westernacher, J., Weygaert, R., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhao, M., Zimmerman, A., Zumalacarregui, M., Barausse, E, Berti, E, Hertog, T, Hughes, S, Jetzer, P, Pani, P, Sotiriou, T, Tamanini, N, Witek, H, Yagi, K, Yunes, N, Abdelsalhin, T, Achucarro, A, van Aelst, K, Afshordi, N, Akcay, S, Annulli, L, Arun, K, Ayuso, I, Baibhav, V, Baker, T, Bantilan, H, Barreiro, T, Barrera-Hinojosa, C, Bartolo, N, Baumann, D, Belgacem, E, Bellini, E, Bellomo, N, Ben-Dayan, I, Bena, I, Benkel, R, Bergshoefs, E, Bernard, L, Bernuzzi, S, Bertacca, D, Besancon, M, Beutler, F, Beyer, F, Bhagwat, S, Bicak, J, Biondini, S, Bize, S, Blas, D, Boehmer, C, Boller, K, Bonga, B, Bonvin, C, Bosso, P, Bozzola, G, Brax, P, Breitbach, M, Brito, R, Bruni, M, Brügmann, B, Bulten, H, Buonanno, A, Burko, L, Burrage, C, Cabral, F, Calcagni, G, Caprini, C, Cárdenas-Avendaño, A, Celoria, M, Chatziioannou, K, Chernoff, D, Clough, K, Coates, A, Comelli, D, Compère, G, Croon, D, Cruces, D, Cusin, G, Dalang, C, Danielsson, U, Das, S, Datta, S, de Boer, J, De Luca, V, De Rham, C, Desjacques, V, Destounis, K, Filippo, F, Dima, A, Dimastrogiovanni, E, Dolan, S, Doneva, D, Duque, F, Durrer, R, East, W, Easther, R, Elley, M, Ellis, J, Emparan, R, Ezquiaga, J, Fairbairn, M, Fairhurst, S, Farmer, H, Fasiello, M, Ferrari, V, Ferreira, P, Ficarra, G, Figueras, P, Fisenko, S, Foffa, S, Franchini, N, Franciolini, G, Fransen, K, Frauendiener, J, Frusciante, N, Fujita, R, Gair, J, Ganz, A, Garcia, P, Garcia-Bellido, J, Garriga, J, Geiger, R, Geng, C, Gergely, L, Germani, C, Gerosa, D, Giddings, S, Gourgoulhon, E, Grandclement, P, Graziani, L, Gualtieri, L, Haggard, D, Haino, S, Halburd, R, Han, W, Hawken, A, Hees, A, Heng, I, Hennig, J, Herdeiro, C, Hervik, S, Holten, J, Hoyle, C, Hu, Y, Hull, M, Ikeda, T, Isi, M, Jenkins, A, Julié, F, Kajfasz, E, Kalaghatgi, C, Kaloper, N, Kamionkowski, M, Karas, V, Kastha, S, Keresztes, Z, Kidder, L, Kimpson, T, Klein, A, Klioner, S, Kokkotas, K, Kolesova, H, Kolkowitz, S, Kopp, J, Koyama, K, Krishnendu, N, Kroon, J, Kunz, M, Lahav, O, Landragin, A, Lang, R, Poncin-Lafitte, C, Lemos, J, Li, B, Liberati, S, Liguori, M, Lin, F, Liu, G, Lobo, F, Loll, R, Lombriser, L, Lovelace, G, Macedo, R, Madge, E, Maggio, E, Maggiore, M, Marassi, S, Marcoccia, P, Markakis, C, Martens, W, Martinovic, K, Martins, C, Maselli, A, Mastrogiovanni, S, Matarrese, S, Matas, A, Mavromatos, N, Mazumdar, A, Meerburg, P, Megias, E, Miller, J, Mimoso, J, Mittnacht, L, Montero, M, Moore, B, Martin-Moruno, P, Musco, I, Nakano, H, Nampalliwar, S, Nardini, G, Nielsen, A, Novák, J, Nunes, N, Okounkova, M, Oliveri, R, Oppizzi, F, Orlando, G, Oshita, N, Pappas, G, Paschalidis, V, Peiris, H, Peloso, M, Perkins, S, Pettorino, V, Pikovski, I, Pilo, L, Podolsky, J, Pontzen, A, Prabhat, S, Pratten, G, Prokopec, T, Prouza, M, Qi, H, Raccanelli, A, Rajantie, A, Randall, L, Raposo, G, Raymond, V, Renaux-Petel, S, Ricciardone, A, Riotto, A, Robson, T, Roest, D, Rollo, R, Rosofsky, S, Ruan, J, Rubiera-García, D, Ruiz, M, Rusu, M, Sabatie, F, Sago, N, Sakellariadou, M, Saltas, I, Sberna, L, Sathyaprakash, B, Scheel, M, Schmidt, P, Schutz, B, Schwaller, P, Shao, L, Shapiro, S, Shoemaker, D, Silva, A, Simpson, C, Sopuerta, C, Spallicci, A, Stefanek, B, Stein, L, Stergioulas, N, Stott, M, Sutton, P, Svarc, R, Tagoshi, H, Tahamtan, T, Takeda, H, Tanaka, T, Tantilian, G, Tasinato, G, Tattersall, O, Teukolsky, S, Tiec, A, Theureau, G, Trodden, M, Tolley, A, Toubiana, A, Traykova, D, Tsokaros, A, Unal, C, Unnikrishnan, C, Vagenas, E, Valageas, P, Vallisneri, M, Brand, J, Broeck, C, de Meent, M, Vanhove, P, Varma, V, Veitch, J, Vercnocke, B, Verde, L, Vernieri, D, Vernizzi, F, Vicente, R, Vidotto, F, Visser, M, Vlah, Z, Vretinaris, S, Völkel, S, Wang, Q, Wang, Y, Werner, M, Westernacher, J, Weygaert, R, Wiltshire, D, Wiseman, T, Wolf, P, Wu, K, Yamada, K, Yang, H, Yi, L, Yue, X, Yvon, D, Zilhão, M, Zimmerman, A, Zumalacarregui, M, Van Swinderen Institute for Particle Physics and G, High-Energy Frontier, Cosmic Frontier, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Centre National d’Études Spatiales [Paris] (CNES)
Subjects: Physics and Astronomy (miscellaneous), 01 natural sciences, General Relativity and Quantum Cosmology, GRAVITATIONAL-WAVES, Physics, Particles & Fields, CONSTANT, Física matemática, GENERAL-RELATIVITY, 010303 astronomy & astrophysics, Fundamental physics, Physics, 0105 Mathematical Physics, Gravitational waves, LISA, General Relativity and Cosmology, fundamental physics, Nuclear & Particles Physics, Variety (cybernetics), GAS PILE-UP, Physical Sciences, TESTS, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], proposed experiment, Gravitational wave, Física-Modelos matemáticos, gr-qc, Physics, Multidisciplinary, FOS: Physical sciences, Sample (statistics), General Relativity and Quantum Cosmology (gr-qc), Astronomy & Astrophysics, Fundamental physic, 1.5 MIGRATION, Settore FIS/05 - Astronomia e Astrofisica, GRAVITY, 0201 Astronomical and Space Sciences, 0103 physical sciences, 0206 Quantum Physics, BLACK-HOLES, Science & Technology, OVERFLOW, 010308 nuclear & particles physics, Principal (computer security), 22/2 OA procedure, gravitational radiation, Data science, EVOLUTION
Abstract: 33 pags., 1 fig., In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a “science-first” approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics., E. Barausse, A. Dima, N. Franchini and S. Völkel acknowledge financial support provided under the European Union’s H2020 ERC Consolidator Grant “GRavity from Astrophysical to Microscopic Scales” Grant agreement No. GRAMS-815673. This work has also been supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant agreement No. 690904. The authors would like to acknowledge financial and networking support by the GWverse COST Action CA16104, “Black holes, gravitational waves and fundamental physics”; the European Research Council Starting Grant DarkGRA-757480 (“Unveiling the dark universe with gravitational waves”) and the Flemish Research Council through the Odysseus Grant G.0011.12. H. Witek acknowledges financial support provided by the Royal Society University Research Fellowship UF160547 and the Royal Society Research Grant RGF\R1\180073. S.A. Hughes’s work on LISA-related science is supported by NASA Grant No. 80NSSC18K1091. E. Berti is supported by NSF Grants No. PHY-1912550 and AST-1841358, NASA ATP Grants No. 17-ATP17-0225 and 19-ATP19-0051, and NSF-XSEDE Grant No. PHY-090003. N.Yunes acknowledges support from NSF grant PHY-1759615, and NASA Grants 80NSSC18K1352. K. Yagi acknowledges support from NSF Award PHY-1806776, a Sloan Foundation Research Fellowship, and the Ed Owens Fund. T. P. Sotiriou acknowledges partial support from the STFC Consolidated Grant No. ST/P000703/1.We would like to thank all of the attendees of the first, inaugural meeting of the Fundamental Physics Research Group in Florence for interesting and stimulating discussions and presentations. We would also like to thank the Galileo Galilei Institute for their hospitality during the organization of this meeting. E. Barausse, A. Dima, N. Franchini and S. Völkel acknowledge financial support provided under the European Union’s H2020 ERC Consolidator Grant “GRavity from Astrophysical to Microscopic Scales” Grant agreement No. GRAMS-815673. This work has also been supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant agreement No. 690904. The authors would like to acknowledge financial and networking support by the GWverse COST Action CA16104, “Black holes, gravitational waves and fundamental physics”; the European Research Council Starting Grant DarkGRA-757480 (“Unveiling the dark universe with gravitational waves”) and the Flemish Research Council through the Odysseus Grant G.0011.12. H. Witek acknowledges financial support provided by the Royal Society University Research Fellowship UF160547 and the Royal Society Research Grant RGF\R1\180073. S.A. Hughes’s work on LISA-related science is supported by NASA Grant No. 80NSSC18K1091. E. Berti is supported by NSF Grants No. PHY-1912550 and AST-1841358, NASA ATP Grants No. 17-ATP17-0225 and 19-ATP19-0051, and NSF-XSEDE Grant No. PHY-090003. N.Yunes acknowledges support from NSF grant PHY-1759615, and NASA Grants 80NSSC18K1352. K. Yagi acknowledges support from NSF Award PHY-1806776, a Sloan Foundation Research Fellowship, and the Ed Owens Fund. T. P. Sotiriou acknowledges partial support from the STFC Consolidated Grant No. ST/P000703/1.
Published: 2020

4. Toll-Like Receptor Responsiveness of Peripheral Blood Mononuclear Cells in Young Women with Dysmenorrhea

Author: Evans, Susan F, Kwok, Yuen H, Solterbeck, Ann, Liu, Jiajun, Hutchinson, Mark R, Hull, M Louise, and Rolan, Paul E
Subjects: endometriosis, IL-1β, pain, pelvic pain, Journal of Pain Research, chronic pain, oral contraceptive pill, Original Research
Abstract: Susan F Evans,1 Yuen H Kwok,2 Ann Solterbeck,3 Jiajun Liu,2 Mark R Hutchinson,1,4 M Louise Hull,5 Paul E Rolan6 1Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; 2Faculty of Health Science, University of Adelaide, Adelaide, South Australia, Australia; 3Statistical Revelations, Melbourne, Victoria, Australia; 4Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, University of Adelaide, Adelaide, South Australia, Australia; 5Robinson Research Institute, School or Pediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia; 6School of Medicine, University of Adelaide, Adelaide, South Australia, AustraliaCorrespondence: Susan F Evans Tel +61 418 849 895Email susan.evans@adelaide.edu.auPurpose: Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. To determine whether there is evidence of activation of the innate immune system in dysmenorrhea and whether the degree of activation may be used as a biomarker for pain, we compared the responsiveness of peripheral blood mononuclear cells (PBMCs) to toll-like receptor (TLR) 2 or 4 stimulation. We also investigated whether this effect is modulated by the use of the oral contraceptive pill (OC).Patients and Methods: Fifty-six women aged 16– 35 years, with either severe or minimal dysmenorrhea, and use or non-use of the OC, were enrolled. PBMCs were collected on two occasions in a single menstrual cycle: the menstrual phase and the mid-follicular phase. PBMCs were exposed to lipopolysaccharide (LPS), a TLR4 agonist, and PAM3CSK4 (PAM), a TLR2 agonist, and the resulting interleukin-1beta (IL– 1β) output was determined. Statistical analysis compared the EC50 between groups as a measure of TLR responsiveness of PBMCs.Results: The key finding following LPS stimulation was a pain effect of dysmenorrhea (p=0.042) that was independent of use or non-use of OC, and independent of day of testing. Women with dysmenorrhea showed a large 2.15-fold (95% CI − 4.69, − 0.09) increase in IL– 1β release when compared with pain-free participants across both days.Conclusion: This is the first study to demonstrate an ex vivo immune relationship in women with dysmenorrhea-related pelvic pain. It provides evidence for the potential of immune modulation as a novel pharmacological target for future drug development in the management of dysmenorrhea.Keywords: pain, chronic pain, oral contraceptive pill, endometriosis, pelvic pain, IL-1&beta
Published: 2020

5. Elevated Triglycerides (≥150 mg/dL) and High Triglycerides (200–499 mg/dL) Are Significant Predictors of New Heart Failure Diagnosis: A Real-World Analysis of High-Risk Statin-Treated Patients

Author: Toth PP, Philip S, Hull M, and Granowitz C
Subjects: lcsh:Diseases of the circulatory (Cardiovascular) system, cardiovascular disease, lcsh:RC666-701, hypertriglyceridemia, costs, statins
Abstract: Peter P Toth,1,2 Sephy Philip,3 Michael Hull,4 Craig Granowitz3 1CGH Medical Center, Sterling, IL, USA; 2Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3Amarin Pharma Inc, Bedminster, NJ, USA; 4Optum, Eden Prairie, MN, USACorrespondence: Peter P TothCGH Medical Center, 101 East Miller Road, Sterling, IL 61081, USATel +1 815-632-5093Fax +1 815-626-5947Email Peter.Toth@cghmc.comPurpose: Real-world data may provide insight into relationships between high triglycerides (TG), a modifiable cardiovascular (CV) risk factor, and increased heart failure (HF) risk.Patients and methods: This retrospective administrative claims analysis included statin-treated patients aged ≥45 years with diabetes and/or atherosclerotic CV disease enrolled in 2010 and followed for ≥6 months to March 2016. Patients with TG ≥150 mg/dL and a comparator cohort with TG 40 mg/dL were included. A sub-analysis was conducted in patients with TG 200–499 mg/dL. Hazard ratios (HR) were calculated from multivariate analyses controlled for patient characteristics and comorbidities using Cox proportional hazard modeling. New diagnosis of HF required diagnosis in the follow-up period without prior evidence of HF.Results: Multivariate analyses revealed a 19% higher rate of new HF diagnosis in the TG ≥150 mg/dL cohort (HR=1.192; 95% confidence interval [CI]=1.134–1.252; P
Published: 2019

6. Which Asymmetric Tibial Component is Optimally Designed for Calipered Kinematically Aligned TKA?

Author: Nedopil, A, Howell, S, Hull, M, and Rudert, M
Subjects: musculoskeletal diseases, Total Knee Replacement, ddc: 610, Kinematic Alignment, Flexion-Extension Plane, Medicine and health, Tibial Coverage, Knee Arthroplasty, musculoskeletal system
Abstract: Objectives: Calipered kinematically aligned (KA) total knee arthroplasty (TKA) restores the patient's pre-arthritic joint lines and sets internal-external (IE) rotation of the tibial component parallel to the flexion-extension (FE) plane, which is not a mechanical alignment (MA) target. Two asym-metric [for full text, please go to the a.m. URL]
Published: 2021
Full Text: View/download PDF

7. sj-pdf-2-whe-10.1177_17455065211019717 – Supplemental material for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Author: Delanerolle, Gayathri, Ramakrishnan, Rema, Hapangama, Dharani, Zeng, Yutian, Shetty, Ashish, Elneil, Sohier, Chong, Sam, Hirsch, Martin, Oyewole, Molola, Phiri, Peter, Elliot, Kathryn, Kothari, Trusha, Rogers, Bryony, Sandle, Natasha, Haque, Nyla, Pluchino, Nicola, Silem, Martin, O’Hara, Rebecca, Hull, M Louise, Majumder, Kingshuk, Shi, Jian Qing, and Raymont, Vanessa
Subjects: FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract: Supplemental material, sj-pdf-2-whe-10.1177_17455065211019717 for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project by Gayathri Delanerolle, Rema Ramakrishnan, Dharani Hapangama, Yutian Zeng, Ashish Shetty, Sohier Elneil, Sam Chong, Martin Hirsch, Molola Oyewole, Peter Phiri, Kathryn Elliot, Trusha Kothari, Bryony Rogers, Natasha Sandle, Nyla Haque, Nicola Pluchino, Martin Silem, Rebecca O’Hara, M Louise Hull, Kingshuk Majumder, Jian Qing Shi and Vanessa Raymont in Women’s Health
Published: 2021
Full Text: View/download PDF

8. sj-pdf-2-whe-10.1177_17455065211019717 – Supplemental material for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Author: Delanerolle, Gayathri, Ramakrishnan, Rema, Hapangama, Dharani, Zeng, Yutian, Shetty, Ashish, Elneil, Sohier, Chong, Sam, Hirsch, Martin, Oyewole, Molola, Phiri, Peter, Elliot, Kathryn, Kothari, Trusha, Rogers, Bryony, Sandle, Natasha, Haque, Nyla, Pluchino, Nicola, Silem, Martin, O’Hara, Rebecca, Hull, M Louise, Majumder, Kingshuk, Shi, Jian Qing, and Raymont, Vanessa
Subjects: FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract: Supplemental material, sj-pdf-2-whe-10.1177_17455065211019717 for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project by Gayathri Delanerolle, Rema Ramakrishnan, Dharani Hapangama, Yutian Zeng, Ashish Shetty, Sohier Elneil, Sam Chong, Martin Hirsch, Molola Oyewole, Peter Phiri, Kathryn Elliot, Trusha Kothari, Bryony Rogers, Natasha Sandle, Nyla Haque, Nicola Pluchino, Martin Silem, Rebecca O’Hara, M Louise Hull, Kingshuk Majumder, Jian Qing Shi and Vanessa Raymont in Women’s Health
Published: 2021
Full Text: View/download PDF

9. sj-pdf-3-whe-10.1177_17455065211019717 – Supplemental material for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Author: Delanerolle, Gayathri, Ramakrishnan, Rema, Hapangama, Dharani, Zeng, Yutian, Shetty, Ashish, Elneil, Sohier, Chong, Sam, Hirsch, Martin, Oyewole, Molola, Phiri, Peter, Elliot, Kathryn, Kothari, Trusha, Rogers, Bryony, Sandle, Natasha, Haque, Nyla, Pluchino, Nicola, Silem, Martin, O’Hara, Rebecca, Hull, M Louise, Majumder, Kingshuk, Shi, Jian Qing, and Raymont, Vanessa
Subjects: FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract: Supplemental material, sj-pdf-3-whe-10.1177_17455065211019717 for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project by Gayathri Delanerolle, Rema Ramakrishnan, Dharani Hapangama, Yutian Zeng, Ashish Shetty, Sohier Elneil, Sam Chong, Martin Hirsch, Molola Oyewole, Peter Phiri, Kathryn Elliot, Trusha Kothari, Bryony Rogers, Natasha Sandle, Nyla Haque, Nicola Pluchino, Martin Silem, Rebecca O’Hara, M Louise Hull, Kingshuk Majumder, Jian Qing Shi and Vanessa Raymont in Women’s Health
Published: 2021
Full Text: View/download PDF

10. sj-pdf-1-whe-10.1177_17455065211019717 – Supplemental material for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Author: Delanerolle, Gayathri, Ramakrishnan, Rema, Hapangama, Dharani, Zeng, Yutian, Shetty, Ashish, Elneil, Sohier, Chong, Sam, Hirsch, Martin, Oyewole, Molola, Phiri, Peter, Elliot, Kathryn, Kothari, Trusha, Rogers, Bryony, Sandle, Natasha, Haque, Nyla, Pluchino, Nicola, Silem, Martin, O’Hara, Rebecca, Hull, M Louise, Majumder, Kingshuk, Shi, Jian Qing, and Raymont, Vanessa
Subjects: FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract: Supplemental material, sj-pdf-1-whe-10.1177_17455065211019717 for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project by Gayathri Delanerolle, Rema Ramakrishnan, Dharani Hapangama, Yutian Zeng, Ashish Shetty, Sohier Elneil, Sam Chong, Martin Hirsch, Molola Oyewole, Peter Phiri, Kathryn Elliot, Trusha Kothari, Bryony Rogers, Natasha Sandle, Nyla Haque, Nicola Pluchino, Martin Silem, Rebecca O’Hara, M Louise Hull, Kingshuk Majumder, Jian Qing Shi and Vanessa Raymont in Women’s Health
Published: 2021
Full Text: View/download PDF

11. sj-pdf-3-whe-10.1177_17455065211019717 – Supplemental material for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Author: Delanerolle, Gayathri, Ramakrishnan, Rema, Hapangama, Dharani, Zeng, Yutian, Shetty, Ashish, Elneil, Sohier, Chong, Sam, Hirsch, Martin, Oyewole, Molola, Phiri, Peter, Elliot, Kathryn, Kothari, Trusha, Rogers, Bryony, Sandle, Natasha, Haque, Nyla, Pluchino, Nicola, Silem, Martin, O’Hara, Rebecca, Hull, M Louise, Majumder, Kingshuk, Shi, Jian Qing, and Raymont, Vanessa
Subjects: FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract: Supplemental material, sj-pdf-3-whe-10.1177_17455065211019717 for A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project by Gayathri Delanerolle, Rema Ramakrishnan, Dharani Hapangama, Yutian Zeng, Ashish Shetty, Sohier Elneil, Sam Chong, Martin Hirsch, Molola Oyewole, Peter Phiri, Kathryn Elliot, Trusha Kothari, Bryony Rogers, Natasha Sandle, Nyla Haque, Nicola Pluchino, Martin Silem, Rebecca O’Hara, M Louise Hull, Kingshuk Majumder, Jian Qing Shi and Vanessa Raymont in Women’s Health
Published: 2021
Full Text: View/download PDF

12. Research Priorities for Endometriosis

Author: Rogers, Peter A W, Adamson, G David, Al-Jefout, Moamar, Becker, Christian M, D'Hooghe, Thomas M, Dunselman, Gerard A J, Fazleabas, Asgerally, Giudice, Linda C, Horne, Andrew W, Hull, M Louise, Hummelshoj, Lone, Missmer, Stacey A, Montgomery, Grant W, Stratton, Pamela, Taylor, Robert N, Rombauts, Luk, Saunders, Philippa T, Vincent, Katy, Zondervan, Krina T, and Nyegaard, Mette
Subjects: 0301 basic medicine, endometriosis, medicine.medical_specialty, Alternative medicine, Endometriosis, Reproductive medicine, Translational research, LAPAROSCOPIC RADICAL EXCISION, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), DEEPLY INFILTRATING ENDOMETRIOSIS, QUALITY-OF-LIFE, SEGMENTAL BOWEL RESECTION, Research policy, medicine, PERITONEAL ENDOMETRIOSIS, CHRONIC PELVIC PAIN, GENOME-WIDE ASSOCIATION, MESENCHYMAL TRANSITION, 030219 obstetrics & reproductive medicine, consensus report, business.industry, Symptom management, Obstetrics and Gynecology, international workshop, medicine.disease, PHENOTYPE DATA-COLLECTION, 030104 developmental biology, research priorities, Family medicine, Consensus Workshops, business, IN-VITRO FERTILIZATION
Abstract: © The Author(s) 2016. The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17-20, 2017, in Vancouver, British Columbia, Canada.
Published: 2017

13. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing (vol 51, pg 414, 2019)

Author: Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A, Bellenguez, C, Frizatti, A, Chouraki, V, Martin, ER, Sleegers, K, Badarinarayan, N, Jakobsdottir, J, Hamilton-Nelson, KL, Moreno-Grau, S, Olaso, R, Raybould, R, Chen, YN, Kuzma, AB, Hiltunen, M, Morgan, T, Ahmad, S, Vardarajan, BN, Epelbaum, J, Hoffmann, P, Boada, M, Beecham, GW, Garnier, JG, Harold, D, Fitzpatrick, AL, Valladares, O, Moutet, ML, Gerrish, A, Smith, AV, Qu, LM, Bacq, D, Denning, N, Jian, XQ, Zhao, Y, Del Zompo, M, Fox, NC, Choi, SH, Mateo, I, Hughes, JT, Adams, HH, Malamon, J, Sanchez-Garcia, F, Patel, Y, Brody, JA, Dombroski, BA, Naranjo, MCD, Daniilidou, M, Eiriksdottir, G, Mukherjee, S, Wallon, D, Uphill, J, Aspelund, T, Cantwell, LB, Garzia, F, Galimberti, D, Hofer, E, Butkiewicz, M, Fin, B, Scarpini, E, Sarnowski, C, Bush, WS, Meslage, S, Kornhuber, J, White, CC, Song, Y, Barber, RC, Engelborghs, S, Sordon, S, Voijnovic, D, Adams, PM, Vandenberghe, R, Mayhaus, M, Cupples, LA, Albert, MS, De Deyn, PP, Gu, W, Himali, JJ, Beekly, D, Squassina, A, Hartmann, AM, Orellana, A, Blacker, D, Rodriguez-Rodriguez, E, Lovestone, S, Garcia, ME, Doody, RS, Munoz-Fernadez, C, Sussams, R, Lin, HH, Fairchild, TJ, Benito, YA, Holmes, C, Karamujic-Comic, H, Frosch, MP, Thonberg, H, Maier, W, Roshchupkin, G, Ghetti, B, Giedraitis, V, Kawalia, A, Li, S, Huebinger, RM, Kilander, L, Moebus, S, Hernandez, I, Kamboh, MI, Brundin, R, Turton, J, Yang, Q, Katz, MJ, Concari, L, Lord, J, Beiser, AS, Keene, CD, Helisalmi, S, Kloszewska, I, Kukull, WA, Koivisto, AM, Lynch, A, Tarraga, L, Larson, EB, Haapasalo, A, Lawlor, B, Mosley, TH, Lipton, RB, Solfrizzi, V, Gill, M, Longstreth, WT, Montine, TJ, Frisardi, V, Diez-Fairen, M, Rivadeneira, F, Petersen, RC, Deramecourt, V, Alvarez, I, Salani, F, Ciaramella, A, Boerwinkle, E, Reiman, EM, Fievet, N, Rotter, JI, Reisch, JS, Hanon, O, Cupidi, C, Uitterlinden, AGA, Royall, DR, Dufouil, C, Maletta, RG, de Rojas, I, Sano, M, Brice, A, Cecchetti, R, St George-Hyslop, P, Ritchie, K, Tsolaki, M, Tsuang, DW, Dubois, B, Craig, D, Wu, CK, Soininen, H, Avramidou, D, Albin, RL, Fratiglioni, L, Germanou, A, Apostolova, LG, Keller, L, Koutroumani, M, Arnold, SE, Panza, F, Gkatzima, O, Asthana, S, Hannequin, D, Whitehead, P, Atwood, CS, Caffarra, P, Hampel, H, Quintela, I, Carracedo, A, Lannfelt, L, Rubinsztein, DC, Barnes, LL, Pasquier, F, Frolich, L, Barral, S, McGuinness, B, Beach, TG, Johnston, JA, Becker, JT, Passmore, P, Bigio, EH, Schott, JM, Bird, TD, Warren, JD, Boeve, BF, Lupton, MK, Bowen, JD, Proitsi, P, Boxer, A, Powell, JF, Burke, JR, Kauwe, JSK, Burns, JM, Mancuso, M, Buxbaum, JD, Bonuccelli, U, Cairns, NJ, McQuillin, A, Cao, CH, Livingston, G, Carlson, CS, Bass, NJ, Carlsson, CM, Hardy, J, Carney, RM, Bras, J, Carrasquillo, MM, Guerreiro, R, Allen, M, Chui, HC, Fisher, E, Masullo, C, Crocco, EA, DeCarli, C, Bisceglio, G, Dick, M, Ma, L, Duara, R, Graff-Radford, NR, Evans, DA, Hodges, A, Faber, KM, Scherer, M, Fallon, KB, Riemenschneider, M, Fardo, DW, Heun, R, Farlow, MR, Kolsch, H, Ferris, S, Leber, M, Foroud, TM, Heuser, I, Galasko, DR, Giegling, I, Gearing, M, Hull, M, Geschwind, DH, Gilbert, JR, Morris, J, Green, RC, Mayo, K, Growdon, JH, Feulner, T, Hamilton, RL, Harrell, LE, Drichel, D, Honig, LS, Cushion, TD, Huentelman, MJ, Hollingworth, P, Hulette, CM, Hyman, BT, Marshall, R, Jarvik, GP, Meggy, A, Abner, E, Menzies, GE, Jin, LW, Leonenko, G, Real, LM, Jun, GR, Baldwin, CT, Grozeva, D, Karydas, A, Russo, G, Kaye, JA, Kim, R, Jessen, F, Kowall, NW, Vellas, B, Kramer, JH, Vardy, E, LaFerla, FM, Jockel, KH, Lah, JJ, Dichgans, M, Leverenz, JB, Mann, D, Levey, AI, Pickering-Brown, S, Lieberman, AP, Klopp, N, Lunetta, KL, Wichmann, HE, Lyketsos, CG, Morgan, K, Marson, DC, Brown, K, Martiniuk, F, Medway, C, Mash, DC, Nothen, MM, Masliah, E, Hooper, NM, McCormick, WC, Daniele, A, McCurry, SM, Bayer, A, McDavid, AN, Gallacher, J, Mckee, AC, van den Bussche, H, Mesulam, M, Brayne, C, Miller, BL, Riedel-Heller, S, Miller, CA, Miller, JW, Al-Chalabi, A, Morris, JC, Shaw, CE, Myers, AJ, Wiltfang, J, O'Bryant, S, Olichney, JM, Alvarez, V, Parisi, JE, Singleton, AB, Paulson, HL, Collinge, J, Perry, WR, Mead, S, Peskind, E, Cribbs, DH, Rossor, M, Pierce, A, Ryan, NS, Poon, WW, Nacmias, B, Potter, H, Sorbi, S, Quinn, JF, Sacchinelli, E, Raj, A, Spalletta, G, Raskind, M, Caltagirone, C, Bossu, P, Orfei, MD, Reisberg, B, Clarke, R, Reitz, C, Smith, AD, Ringman, JM, Warden, D, Roberson, ED, Wilcock, G, Rogaeva, E, Bruni, AC, Rosen, HJ, Gallo, M, Rosenberg, RN, Ben-Shlomo, Y, Sager, MA, Mecocci, P, Saykin, AJ, Pastor, P, Cuccaro, ML, Vance, JM, Schneider, JA, Schneider, LS, Slifer, S, Seeley, WW, Smith, AG, Sonnen, JA, Spina, S, Stern, RA, Swerdlow, RH, Tang, M, Tanzi, RE, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Van Eldik, LJ, Vinters, HV, Vonsattel, JP, Weintraub, S, Welsh-Bohmer, KA, Wilhelmsen, KC, Williamson, J, Wingo, TS, Woltjer, RL, Wright, CB, Yu, CE, Yu, L, Saba, Y, Pilotto, A, Bullido, MJ, Peters, O, Crane, PK, Bennett, D, Bosco, P, Coto, E, Boccardi, V, De Jager, PL, Lleo, A, Warner, N, Lopez, OL, Ingelsson, M, Deloukas, P, Cruchaga, C, Graff, C, Gwilliam, R, Fornage, M, Goate, AM, Sanchez-Juan, P, Kehoe, PG, Amin, N, Ertekin-Taner, N, Berr, C, Debette, S, Love, S, Launer, LJ, Younkin, SG, Dartigues, JF, Corcoran, C, Ikram, MA, Dickson, DW, Nicolas, G, Campion, D, Tschanz, J, Schmidt, H, Hakonarson, H, Clarimon, J, Munger, R, Schmidt, R, Farrer, LA, Van Broeckhoven, C, O'Donovan, MC, DeStefano, AL, Jones, L, Haines, JL, Deleuze, JF, Owen, MJ, Gudnason, V, Mayeux, R, Escott-Price, V, Psaty, BM, Ramirez, A, Wang, LS, Ruiz, A, van Duijn, CM, Holmans, PA, Seshadri, S, Williams, J, Amouyel, P, Schellenberg, GD, Lambert, JC, Pericak-Vance, MA, ADGC, EADI, Cohorts Heart Aging Res Genomic, and Genetic Environm Risk AD Defining
Published: 2019

14. Nat Genet

Author: KUNKLE, B. W., GRENIER-BOLEY, B., SIMS, R., BIS, J. C., DAMOTTE, V., NAJ, A. C., BOLAND, A., VRONSKAYA, M., VAN DER LEE, S. J., AMLIE-WOLF, A., BELLENGUEZ, C., FRIZATTI, A., CHOURAKI, V., MARTIN, E. R., SLEEGERS, K., BADARINARAYAN, N., JAKOBSDOTTIR, J., HAMILTON-NELSON, K. L., MORENO-GRAU, S., OLASO, R., RAYBOULD, R., CHEN, Y., KUZMA, A. B., HILTUNEN, M., MORGAN, T., AHMAD, S., VARDARAJAN, B. N., EPELBAUM, J., HOFFMANN, P., BOADA, M., BEECHAM, G. W., GARNIER, J. G., HAROLD, D., FITZPATRICK, A. L., VALLADARES, O., MOUTET, M. L., GERRISH, A., QU, L., BACQ, D., DENNING, N., JIAN, X., ZHAO, Y., DEL ZOMPO, M., FOX, N. C., CHOI, S. H., MATEO, I., HUGHES, J. T., ADAMS, H. H., MALAMON, J., SANCHEZ-GARCIA, F., PATEL, Y., BRODY, J. A., DOMBROSKI, B. A., NARANJO, M. C. D., DANIILIDOU, M., EIRIKSDOTTIR, G., MUKHERJEE, S., WALLON, D., UPHILL, J., ASPELUND, T., CANTWELL, L. B., GARZIA, F., GALIMBERTI, D., HOFER, E., BUTKIEWICZ, M., FIN, B., SCARPINI, E., SARNOWSKI, C., BUSH, W. S., MESLAGE, S., KORNHUBER, J., WHITE, C. C., SONG, Y., BARBER, R. C., ENGELBORGHS, S., SORDON, S., VOIJNOVIC, D., ADAMS, P. M., VANDENBERGHE, R., MAYHAUS, M., CUPPLES, L. A., ALBERT, M. S., DE DEYN, P. P., GU, W., HIMALI, J. J., BEEKLY, D., SQUASSINA, A., HARTMANN, A. M., ORELLANA, A., BLACKER, D., RODRIGUEZ-RODRIGUEZ, E., LOVESTONE, S., GARCIA, M. E., DOODY, R. S., MUNOZ-FERNADEZ, C., SUSSAMS, R., LIN, H., FAIRCHILD, T. J., BENITO, Y. A., HOLMES, C., KARAMUJIC-COMIC, H., FROSCH, M. P., THONBERG, H., MAIER, W., ROSCHUPKIN, G., GHETTI, B., GIEDRAITIS, V., KAWALIA, A., LI, S., HUEBINGER, R. M., KILANDER, L., MOEBUS, S., HERNANDEZ, I., KAMBOH, M. I., BRUNDIN, R., TURTON, J., YANG, Q., KATZ, M. J., CONCARI, L., LORD, J., BEISER, A. S., KEENE, C. D., HELISALMI, S., KLOSZEWSKA, I., KUKULL, W. A., KOIVISTO, A. M., LYNCH, A., TARRAGA, L., LARSON, E. B., HAAPASALO, A., LAWLOR, B., MOSLEY, T. H., LIPTON, R. B., SOLFRIZZI, V., GILL, M., LONGSTRETH, W. T. Jr., MONTINE, T. J., FRISARDI, V., DIEZ-FAIREN, M., RIVADENEIRA, F., PETERSEN, R. C., DERAMECOURT, V., ALVAREZ, I., SALANI, F., CIARAMELLA, A., BOERWINKLE, E., REIMAN, E. M., FIEVET, N., ROTTER, J. I., REISCH, J. S., HANON, O., CUPIDI, C., ANDRE UITTERLINDEN, A. G., ROYALL, D. R., DUFOUIL, Carole, MALETTA, R. G., DE ROJAS, I., SANO, M., BRICE, A., CECCHETTI, R., GEORGE-HYSLOP, P. S., RITCHIE, K., TSOLAKI, M., TSUANG, D. W., DUBOIS, B., CRAIG, D., WU, C. K., SOININEN, H., AVRAMIDOU, D., ALBIN, R. L., FRATIGLIONI, L., GERMANOU, A., APOSTOLOVA, L. G., KELLER, L., KOUTROUMANI, M., ARNOLD, S. E., PANZA, F., GKATZIMA, O., ASTHANA, S., HANNEQUIN, D., WHITEHEAD, P., ATWOOD, C. S., CAFFARRA, P., HAMPEL, H., QUINTELA, I., CARRACEDO, A., LANNFELT, L., RUBINSZTEIN, D. C., BARNES, L. L., PASQUIER, F., FROLICH, L., BARRAL, S., MCGUINNESS, B., BEACH, T. G., JOHNSTON, J. A., BECKER, J. T., PASSMORE, P., BIGIO, E. H., SCHOTT, J. M., BIRD, T. D., WARREN, J. D., BOEVE, B. F., LUPTON, M. K., BOWEN, J. D., PROITSI, P., BOXER, A., POWELL, J. F., BURKE, J. R., KAUWE, J. S. K., BURNS, J. M., MANCUSO, M., BUXBAUM, J. D., BONUCCELLI, U., CAIRNS, N. J., MCQUILLIN, A., CAO, C., LIVINGSTON, G., CARLSON, C. S., BASS, N. J., CARLSSON, C. M., HARDY, J., CARNEY, R. M., BRAS, J., CARRASQUILLO, M. M., GUERREIRO, R., ALLEN, M., CHUI, H. C., FISHER, E., MASULLO, C., CROCCO, E. A., DECARLI, C., BISCEGLIO, G., DICK, M., MA, L., DUARA, R., GRAFF-RADFORD, N. R., EVANS, D. A., HODGES, A., FABER, K. M., SCHERER, M., FALLON, K. B., RIEMENSCHNEIDER, M., FARDO, D. W., HEUN, R., FARLOW, M. R., KOLSCH, H., FERRIS, S., LEBER, M., FOROUD, T. M., HEUSER, I., GALASKO, D. R., GIEGLING, I., GEARING, M., HULL, M., GESCHWIND, D. H., GILBERT, J. R., GREEN, R. C., MAYO, K., GROWDON, J. H., FEULNER, T., HAMILTON, R. L., HARRELL, L. E., DRICHEL, D., HONIG, L. S., CUSHION, T. D., HUENTELMAN, M. J., HOLLINGWORTH, P., HULETTE, C. M., HYMAN, B. T., MARSHALL, R., JARVIK, G. P., MEGGY, A., ABNER, E., MENZIES, G. E., JIN, L. W., LEONENKO, G., REAL, L. M., JUN, G. R., BALDWIN, C. T., GROZEVA, D., KARYDAS, A., RUSSO, G., KAYE, J. A., KIM, R., JESSEN, F., KOWALL, N. W., VELLAS, B., KRAMER, J. H., VARDY, E., LAFERLA, F. M., JOCKEL, K. H., LAH, J. J., DICHGANS, M., LEVERENZ, J. B., MANN, D., LEVEY, A. I., PICKERING-BROWN, S., LIEBERMAN, A. P., KLOPP, N., LUNETTA, K. L., WICHMANN, H. E., LYKETSOS, C. G., MORGAN, K., MARSON, D. C., BROWN, K., MARTINIUK, F., MEDWAY, C., MASH, D. C., NOTHEN, M. M., MASLIAH, E., HOOPER, N. M., MCCORMICK, W. C., DANIELE, A., MCCURRY, S. M., BAYER, A., MCDAVID, A. N., GALLACHER, J., MCKEE, A. C., VAN DEN BUSSCHE, H., MESULAM, M., BRAYNE, C., MILLER, B. L., RIEDEL-HELLER, S., MILLER, C. A., MILLER, J. W., AL-CHALABI, A., MORRIS, J. C., SHAW, C. E., MYERS, A. J., WILTFANG, J., O'BRYANT, S., OLICHNEY, J. M., ALVAREZ, V., PARISI, J. E., SINGLETON, A. B., PAULSON, H. L., COLLINGE, J., PERRY, W. R., MEAD, S., PESKIND, E., CRIBBS, D. H., ROSSOR, M., PIERCE, A., RYAN, N. S., POON, W. W., NACMIAS, B., POTTER, H., SORBI, S., QUINN, J. F., SACCHINELLI, E., RAJ, A., SPALLETTA, G., RASKIND, M., CALTAGIRONE, C., BOSSU, P., ORFEI, M. D., REISBERG, B., CLARKE, R., REITZ, C., RINGMAN, J. M., WARDEN, D., ROBERSON, E. D., WILCOCK, G., ROGAEVA, E., BRUNI, A. C., ROSEN, H. J., GALLO, M., ROSENBERG, R. N., BEN-SHLOMO, Y., SAGER, M. A., MECOCCI, P., SAYKIN, A. J., PASTOR, P., CUCCARO, M. L., VANCE, J. M., SCHNEIDER, J. A., SCHNEIDER, L. S., SLIFER, S., SEELEY, W. W., SMITH, A. V., SONNEN, J. A., SPINA, S., STERN, R. A., SWERDLOW, R. H., TANG, M., TANZI, R. E., TROJANOWSKI, J. Q., TRONCOSO, J. C., VAN DEERLIN, V. M., VAN ELDIK, L. J., VINTERS, H. V., VONSATTEL, J. P., WEINTRAUB, S., WELSH-BOHMER, K. A., WILHELMSEN, K. C., WILLIAMSON, J., WINGO, T. S., WOLTJER, R. L., WRIGHT, C. B., YU, C. E., YU, L., SABA, Y., ALZHEIMER DISEASE GENETICS, Consortium, EUROPEAN ALZHEIMER'S DISEASE, Initiative, COHORTS FOR, Heart, AGING RESEARCH IN GENOMIC EPIDEMIOLOGY, Consortium, GENETIC ENVIRONMENTAL RISK IN AD/DEFINING GENETIC, Polygenic, ENVIRONMENTAL RISK FOR ALZHEIMER'S DISEASE, Consortium, PILOTTO, A., BULLIDO, M. J., PETERS, O., CRANE, P. K., BENNETT, D., BOSCO, P., COTO, E., BOCCARDI, V., DE JAGER, P. L., LLEO, A., WARNER, N., LOPEZ, O. L., INGELSSON, M., DELOUKAS, P., CRUCHAGA, C., GRAFF, C., GWILLIAM, R., FORNAGE, M., GOATE, A. M., SANCHEZ-JUAN, P., KEHOE, P. G., AMIN, N., ERTEKIN-TANER, N., BERR, C., DEBETTE, S., LOVE, S., LAUNER, L. J., YOUNKIN, S. G., DARTIGUES, Jean-Francois, CORCORAN, C., IKRAM, M. A., DICKSON, D. W., NICOLAS, G., CAMPION, D., TSCHANZ, J., SCHMIDT, H., HAKONARSON, H., CLARIMON, J., MUNGER, R., SCHMIDT, R., FARRER, L. A., VAN BROECKHOVEN, C., M, C. O' Donovan, DESTEFANO, A. L., JONES, L., HAINES, J. L., DELEUZE, J. F., OWEN, M. J., GUDNASON, V., MAYEUX, R., ESCOTT-PRICE, V., PSATY, B. M., RAMIREZ, A., WANG, L. S., RUIZ, A., VAN DUIJN, C. M., HOLMANS, P. A., SESHADRI, S., WILLIAMS, J., AMOUYEL, P., SCHELLENBERG, G. D., LAMBERT, J. C., and PERICAK-VANCE, M. A.
Published: 2019

15. Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

Author: Kunkle, B. W., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., Boland, A., Vronskaya, M., van der Lee, S. J., Amlie-Wolf, A., Bellenguez, C., Frizatti, A., Chouraki, V., Martin, E. R., Sleegers, K., Badarinarayan, N., Jakobsdottir, J., Hamilton-Nelson, K. L., Moreno-Grau, S., Olaso, R., Raybould, R., Chen, Y., Kuzma, A. B., Hiltunen, M., Morgan, T., Ahmad, S., Vardarajan, B. N., Epelbaum, J., Hoffmann, P., Boada, M., Beecham, G. W., Garnier, J. -G., Harold, D., Fitzpatrick, A. L., Valladares, O., Moutet, M. -L., Gerrish, A., Smith, A. V., Qu, L., Bacq, D., Denning, N., Jian, X., Zhao, Y., Del Zompo, M., Fox, N. C., Choi, S. -H., Mateo, I., Hughes, J. T., Adams, H. H., Malamon, J., Sanchez-Garcia, F., Patel, Y., Brody, J. A., Dombroski, B. A., Naranjo, M. C. D., Daniilidou, M., Eiriksdottir, G., Mukherjee, S., Wallon, D., Uphill, J., Aspelund, T., Cantwell, L. B., Garzia, F., Galimberti, D., Hofer, E., Butkiewicz, M., Fin, B., Scarpini, E., Sarnowski, C., Bush, W. S., Meslage, S., Kornhuber, J., White, C. C., Song, Y., Barber, R. C., Engelborghs, S., Sordon, S., Voijnovic, D., Adams, P. M., Vandenberghe, R., Mayhaus, M., Cupples, L. A., Albert, M. S., De Deyn, P. P., Gu, W., Himali, J. J., Beekly, D., Squassina, A., Hartmann, A. M., Orellana, A., Blacker, D., Rodriguez-Rodriguez, E., Lovestone, S., Garcia, M. E., Doody, R. S., Munoz-Fernadez, C., Sussams, R., Lin, H., Fairchild, T. J., Benito, Y. A., Holmes, C., Karamujic-Comic, H., Frosch, M. P., Thonberg, H., Maier, W., Roshchupkin, G., Ghetti, B., Giedraitis, V., Kawalia, A., Li, S., Huebinger, R. M., Kilander, L., Moebus, S., Hernandez, I., Kamboh, M. I., Brundin, R. M., Turton, J., Yang, Q., Katz, M. J., Concari, L., Lord, J., Beiser, A. S., Keene, C. D., Helisalmi, S., Kloszewska, I., Kukull, W. A., Koivisto, A. M., Lynch, A., Tarraga, L., Larson, E. B., Haapasalo, A., Lawlor, B., Mosley, T. H., Lipton, R. B., Solfrizzi, V., Gill, M., Longstreth, W. T., Montine, T. J., Frisardi, V., Diez-Fairen, M., Rivadeneira, F., Petersen, R. C., Deramecourt, V., Alvarez, I., Salani, F., Ciaramella, A., Boerwinkle, E., Reiman, E. M., Fievet, N., Rotter, J. I., Reisch, J. S., Hanon, O., Cupidi, C., Uitterlinden, A. G. A., Royall, D. R., Dufouil, C., Maletta, R. G., de Rojas, I., Sano, M., Brice, A., Cecchetti, R., George-Hyslop, P. S., Ritchie, K., Tsolaki, M., Tsuang, D. W., Dubois, B., Craig, D., C. -K., Wu, Soininen, H., Avramidou, D., Albin, R. L., Fratiglioni, L., Germanou, A., Apostolova, L. G., Keller, L., Koutroumani, M., Arnold, S. E., Panza, F., Gkatzima, O., Asthana, S., Hannequin, D., Whitehead, P., Atwood, C. S., Caffarra, P., Hampel, H., Quintela, I., Carracedo, A., Lannfelt, L., Rubinsztein, D. C., Barnes, L. L., Pasquier, F., Frolich, L., Barral, S., Mcguinness, B., Beach, T. G., Johnston, J. A., Becker, J. T., Passmore, P., Bigio, E. H., Schott, J. M., Bird, T. D., Warren, J. D., Boeve, B. F., Lupton, M. K., Bowen, J. D., Proitsi, P., Boxer, A., Powell, J. F., Burke, J. R., Kauwe, J. S. K., Burns, J. M., Mancuso, M., Buxbaum, J. D., Bonuccelli, U., Cairns, N. J., Mcquillin, A., Cao, C., Livingston, G., Carlson, C. S., Bass, N. J., Carlsson, C. M., Hardy, J., Carney, R. M., Bras, J., Carrasquillo, M. M., Guerreiro, R., Allen, M., Chui, H. C., Fisher, E., Masullo, Carlo, Crocco, E. A., Decarli, C., Bisceglio, G., Dick, M., Ma, L., Duara, R., Graff-Radford, N. R., Evans, D. A., Hodges, A., Faber, K. M., Scherer, M., Fallon, K. B., Riemenschneider, M., Fardo, D. W., Heun, R., Farlow, M. R., Kolsch, H., Ferris, S., Leber, M., Foroud, T. M., Heuser, I., Galasko, D. R., Giegling, I., Gearing, M., Hull, M., Geschwind, D. H., Gilbert, J. R., Morris, J., Green, R. C., Mayo, K., Growdon, J. H., Feulner, T., Hamilton, R. L., Harrell, L. E., Drichel, D., Honig, L. S., Cushion, T. D., Huentelman, M. J., Hollingworth, P., Hulette, C. M., Hyman, B. T., Marshall, R., Jarvik, G. P., Meggy, A., Abner, E., Menzies, G. E., Jin, L. -W., Leonenko, G., Real, L. M., Jun, G. R., Baldwin, C. T., Grozeva, D., Karydas, A., Russo, G., Kaye, J. A., Kim, R., Jessen, F., Kowall, N. W., Vellas, B., Kramer, J. H., Vardy, E., Laferla, F. M., Jockel, K. -H., Lah, J. J., Dichgans, M., Leverenz, J. B., Mann, D., Levey, A. I., Pickering-Brown, S., Lieberman, A. P., Klopp, N., Lunetta, K. L., Wichmann, H. -E., Lyketsos, C. G., Morgan, K., Marson, D. C., Brown, K., Martiniuk, F., Medway, C., Mash, D. C., Nothen, M. M., Masliah, E., Hooper, N. M., Mccormick, W. C., Daniele, Antonio, Mccurry, S. M., Bayer, A., Mcdavid, A. N., Gallacher, J., Mckee, A. C., van den Bussche, H., Mesulam, M., Brayne, C., Miller, B. L., Riedel-Heller, S., Miller, C. A., Miller, J. W., Al-Chalabi, A., Morris, J. C., Shaw, C. E., Myers, A. J., Wiltfang, J., O'Bryant, S., Olichney, J. M., Alvarez, V., Parisi, J. E., Singleton, A. B., Paulson, H. L., Collinge, J., Perry, W. R., Mead, S., Peskind, E., Cribbs, D. H., Rossor, M., Pierce, A., Ryan, N. S., Poon, W. W., Nacmias, B., Potter, H., Sorbi, S., Quinn, J. F., Sacchinelli, E., Raj, A., Spalletta, Gianfranco, Raskind, M., Caltagirone, C., Bossu, P., Orfei, M. D., Reisberg, B., Clarke, Ronald Victor, Reitz, C., Smith, A. D., Ringman, J. M., Warden, D., Roberson, E. D., Wilcock, G., Rogaeva, E., Bruni, A. C., Rosen, H. J., Gallo, Massimiliano, Rosenberg, R. N., Ben-Shlomo, Y., Sager, M. A., Mecocci, P., Saykin, A. J., Pastor, P., Cuccaro, M. L., Vance, J. M., Schneider, J. A., Schneider, L. S., Slifer, S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Swerdlow, R. H., Tang, M., Tanzi, R. E., Trojanowski, J. Q., Troncoso, J. C., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Wilhelmsen, K. C., Williamson, J., Wingo, T. S., Woltjer, R. L., Wright, C. B., C. -E., Yu, Yu, L., Saba, Y., Pilotto, A., Bullido, M. J., Peters, O., Crane, P. K., Bennett, D., Bosco, P., Coto, E., Boccardi, V., De Jager, P. L., Lleo, A., Warner, N., Lopez, O. L., Ingelsson, M., Deloukas, P., Cruchaga, C., Graff, C., Gwilliam, R., Fornage, M., Goate, A. M., Sanchez-Juan, P., Kehoe, P. G., Amin, N., Ertekin-Taner, N., Berr, C., Debette, S., Love, S., Launer, L. J., Younkin, S. G., Dartigues, J. -F., Corcoran, C., Ikram, M. A., Dickson, D. W., Nicolas, G., Campion, D., Tschanz, J. A., Schmidt, H., Hakonarson, H., Clarimon, J., Munger, R., Schmidt, R., Farrer, L. A., Van Broeckhoven, C., O'Donovan, M. C., Destefano, A. L., Jones, L., Haines, J. L., Deleuze, J. -F., Owen, M. J., Gudnason, V., Mayeux, R., Escott-Price, V., Psaty, B. M., Ramirez, A., Wang, L. -S., Ruiz, A., van Duijn, C. M., Holmans, P. A., Seshadri, S., Williams, J., Amouyel, P., Schellenberg, G. D., Lambert, J. -C., and Pericak-Vance, M. A.
Subjects: Author Correction: Alzheimer’s disease genetic meta-analysis new risk loci Aβ, tau, immunity and lipid processing, Settore MED/26 - NEUROLOGIA, Author Correction: Alzheimer’s disease genetic meta-analysis new risk loci Aβ, tau, immunity and lipid processing
Published: 2019

16. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing

Author: KUNKLE, B. W., GRENIER-BOLEY, B., SIMS, R., BIS, J. C., DAMOTTE, V., NAJ, A. C., BOLAND, A., VRONSKAYA, M., VAN DER LEE, S. J., AMLIE-WOLF, A., BELLENGUEZ, C., FRIZATTI, A., CHOURAKI, V., MARTIN, E. R., SLEEGERS, K., BADARINARAYAN, N., JAKOBSDOTTIR, J., HAMILTON-NELSON, K. L., MORENO-GRAU, S., OLASO, R., RAYBOULD, R., CHEN, Y., KUZMA, A. B., HILTUNEN, M., MORGAN, T., AHMAD, S., VARDARAJAN, B. N., EPELBAUM, J., HOFFMANN, P., BOADA, M., BEECHAM, G. W., GARNIER, J. G., HAROLD, D., FITZPATRICK, A. L., VALLADARES, O., MOUTET, M. L., GERRISH, A., SMITH, A. V., QU, L., BACQ, D., DENNING, N., JIAN, X., ZHAO, Y., DEL ZOMPO, M., FOX, N. C., CHOI, S. H., MATEO, I., HUGHES, J. T., ADAMS, H. H., MALAMON, J., SANCHEZ-GARCIA, F., PATEL, Y., BRODY, J. A., DOMBROSKI, B. A., NARANJO, M. C. D., DANIILIDOU, M., EIRIKSDOTTIR, G., MUKHERJEE, S., WALLON, D., UPHILL, J., ASPELUND, T., CANTWELL, L. B., GARZIA, F., GALIMBERTI, D., HOFER, E., BUTKIEWICZ, M., FIN, B., SCARPINI, E., SARNOWSKI, C., BUSH, W. S., MESLAGE, S., KORNHUBER, J., WHITE, C. C., SONG, Y., BARBER, R. C., ENGELBORGHS, S., SORDON, S., VOIJNOVIC, D., ADAMS, P. M., VANDENBERGHE, R., MAYHAUS, M., CUPPLES, L. A., ALBERT, M. S., DE DEYN, P. P., GU, W., HIMALI, J. J., BEEKLY, D., SQUASSINA, A., HARTMANN, A. M., ORELLANA, A., BLACKER, D., RODRIGUEZ-RODRIGUEZ, E., LOVESTONE, S., GARCIA, M. E., DOODY, R. S., MUNOZ-FERNADEZ, C., SUSSAMS, R., LIN, H., FAIRCHILD, T. J., BENITO, Y. A., HOLMES, C., KARAMUJIC-COMIC, H., FROSCH, M. P., THONBERG, H., MAIER, W., ROSHCHUPKIN, G., GHETTI, B., GIEDRAITIS, V., KAWALIA, A., LI, S., HUEBINGER, R. M., KILANDER, L., MOEBUS, S., HERNANDEZ, I., KAMBOH, M. I., BRUNDIN, R., TURTON, J., YANG, Q., KATZ, M. J., CONCARI, L., LORD, J., BEISER, A. S., KEENE, C. D., HELISALMI, S., KLOSZEWSKA, I., KUKULL, W. A., KOIVISTO, A. M., LYNCH, A., TARRAGA, L., LARSON, E. B., HAAPASALO, A., LAWLOR, B., MOSLEY, T. H., LIPTON, R. B., SOLFRIZZI, V., GILL, M., LONGSTRETH, W. T., Jr., MONTINE, T. J., FRISARDI, V., DIEZ-FAIREN, M., RIVADENEIRA, F., PETERSEN, R. C., DERAMECOURT, V., ALVAREZ, I., SALANI, F., CIARAMELLA, A., BOERWINKLE, E., REIMAN, E. M., FIEVET, N., ROTTER, J. I., REISCH, J. S., HANON, O., CUPIDI, C., UITTERLINDEN, A. G. A., ROYALL, D. R., DUFOUIL, Carole, MALETTA, R. G., DE ROJAS, I., SANO, M., BRICE, A., CECCHETTI, R., GEORGE-HYSLOP, P. S., RITCHIE, K., TSOLAKI, M., TSUANG, D. W., DUBOIS, B., CRAIG, D., WU, C. K., SOININEN, H., AVRAMIDOU, D., ALBIN, R. L., FRATIGLIONI, L., GERMANOU, A., APOSTOLOVA, L. G., KELLER, L., KOUTROUMANI, M., ARNOLD, S. E., PANZA, F., GKATZIMA, O., ASTHANA, S., HANNEQUIN, D., WHITEHEAD, P., ATWOOD, C. S., CAFFARRA, P., HAMPEL, H., QUINTELA, I., CARRACEDO, A., LANNFELT, L., RUBINSZTEIN, D. C., BARNES, L. L., PASQUIER, F., FROLICH, L., BARRAL, S., MCGUINNESS, B., BEACH, T. G., JOHNSTON, J. A., BECKER, J. T., PASSMORE, P., BIGIO, E. H., SCHOTT, J. M., BIRD, T. D., WARREN, J. D., BOEVE, B. F., LUPTON, M. K., BOWEN, J. D., PROITSI, P., BOXER, A., POWELL, J. F., BURKE, J. R., KAUWE, J. S. K., BURNS, J. M., MANCUSO, M., BUXBAUM, J. D., BONUCCELLI, U., CAIRNS, N. J., MCQUILLIN, A., CAO, C., LIVINGSTON, G., CARLSON, C. S., BASS, N. J., CARLSSON, C. M., HARDY, J., CARNEY, R. M., BRAS, J., CARRASQUILLO, M. M., GUERREIRO, R., ALLEN, M., CHUI, H. C., FISHER, E., MASULLO, C., CROCCO, E. A., DECARLI, C., BISCEGLIO, G., DICK, M., MA, L., DUARA, R., GRAFF-RADFORD, N. R., EVANS, D. A., HODGES, A., FABER, K. M., SCHERER, M., FALLON, K. B., RIEMENSCHNEIDER, M., FARDO, D. W., HEUN, R., FARLOW, M. R., KOLSCH, H., FERRIS, S., LEBER, M., FOROUD, T. M., HEUSER, I., GALASKO, D. R., GIEGLING, I., GEARING, M., HULL, M., GESCHWIND, D. H., GILBERT, J. R., MORRIS, J., GREEN, R. C., MAYO, K., GROWDON, J. H., FEULNER, T., HAMILTON, R. L., HARRELL, L. E., DRICHEL, D., HONIG, L. S., CUSHION, T. D., HUENTELMAN, M. J., HOLLINGWORTH, P., HULETTE, C. M., HYMAN, B. T., MARSHALL, R., JARVIK, G. P., MEGGY, A., ABNER, E., MENZIES, G. E., JIN, L. W., LEONENKO, G., REAL, L. M., JUN, G. R., BALDWIN, C. T., GROZEVA, D., KARYDAS, A., RUSSO, G., KAYE, J. A., KIM, R., JESSEN, F., KOWALL, N. W., VELLAS, B., KRAMER, J. H., VARDY, E., LAFERLA, F. M., JOCKEL, K. H., LAH, J. J., DICHGANS, M., LEVERENZ, J. B., MANN, D., LEVEY, A. I., PICKERING-BROWN, S., LIEBERMAN, A. P., KLOPP, N., LUNETTA, K. L., WICHMANN, H. E., LYKETSOS, C. G., MORGAN, K., MARSON, D. C., BROWN, K., MARTINIUK, F., MEDWAY, C., MASH, D. C., NOTHEN, M. M., MASLIAH, E., HOOPER, N. M., MCCORMICK, W. C., DANIELE, A., MCCURRY, S. M., BAYER, A., MCDAVID, A. N., GALLACHER, J., MCKEE, A. C., VAN DEN BUSSCHE, H., MESULAM, M., BRAYNE, C., MILLER, B. L., RIEDEL-HELLER, S., MILLER, C. A., MILLER, J. W., AL-CHALABI, A., MORRIS, J. C., SHAW, C. E., MYERS, A. J., WILTFANG, J., O'BRYANT, S., OLICHNEY, J. M., ALVAREZ, V., PARISI, J. E., SINGLETON, A. B., PAULSON, H. L., COLLINGE, J., PERRY, W. R., MEAD, S., PESKIND, E., CRIBBS, D. H., ROSSOR, M., PIERCE, A., RYAN, N. S., POON, W. W., NACMIAS, B., POTTER, H., SORBI, S., QUINN, J. F., SACCHINELLI, E., RAJ, A., SPALLETTA, G., RASKIND, M., CALTAGIRONE, C., BOSSU, P., ORFEI, M. D., REISBERG, B., CLARKE, R., REITZ, C., SMITH, A. D., RINGMAN, J. M., WARDEN, D., ROBERSON, E. D., WILCOCK, G., ROGAEVA, E., BRUNI, A. C., ROSEN, H. J., GALLO, M., ROSENBERG, R. N., BEN-SHLOMO, Y., SAGER, M. A., MECOCCI, P., SAYKIN, A. J., PASTOR, P., CUCCARO, M. L., VANCE, J. M., SCHNEIDER, J. A., SCHNEIDER, L. S., SLIFER, S., SEELEY, W. W., SMITH, A. G., SONNEN, J. A., SPINA, S., STERN, R. A., SWERDLOW, R. H., TANG, M., TANZI, R. E., TROJANOWSKI, J. Q., TRONCOSO, J. C., VAN DEERLIN, V. M., VAN ELDIK, L. J., VINTERS, H. V., VONSATTEL, J. P., WEINTRAUB, S., WELSH-BOHMER, K. A., WILHELMSEN, K. C., WILLIAMSON, J., WINGO, T. S., WOLTJER, R. L., WRIGHT, C. B., YU, C. E., YU, L., SABA, Y., PILOTTO, A., BULLIDO, M. J., PETERS, O., CRANE, P. K., BENNETT, D., BOSCO, P., COTO, E., BOCCARDI, V., DE JAGER, P. L., LLEO, A., WARNER, N., LOPEZ, O. L., INGELSSON, M., DELOUKAS, P., CRUCHAGA, C., GRAFF, C., GWILLIAM, R., FORNAGE, M., GOATE, A. M., SANCHEZ-JUAN, P., KEHOE, P. G., AMIN, N., ERTEKIN-TANER, N., BERR, C., DEBETTE, Stephanie, LOVE, S., LAUNER, L. J., YOUNKIN, S. G., DARTIGUES, Jean-Francois, CORCORAN, C., IKRAM, M. A., DICKSON, D. W., NICOLAS, G., CAMPION, D., TSCHANZ, J., SCHMIDT, H., HAKONARSON, H., CLARIMON, J., MUNGER, R., SCHMIDT, R., FARRER, L. A., VAN BROECKHOVEN, C., O'DONOVAN, M. C., DESTEFANO, A. L., JONES, L., HAINES, J. L., DELEUZE, J. F., OWEN, M. J., GUDNASON, V., MAYEUX, R., ESCOTT-PRICE, V., PSATY, B. M., RAMIREZ, A., WANG, L. S., RUIZ, A., VAN DUIJN, C. M., HOLMANS, P. A., SESHADRI, S., WILLIAMS, J., AMOUYEL, P., SCHELLENBERG, G. D., LAMBERT, J. C., PERICAK-VANCE, M. A., Clinical sciences, Neurology, and Pathologic Biochemistry and Physiology
Subjects: Medicine(all), MEDLINE, Medizin, Disease, Computational biology, Biology, medicine.disease, Article, Immunity, Alzheimer Disease, ddc:570, Meta-analysis, Genetics, medicine, Alzheimer's disease
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2019

17. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing

Author: KUNKLE, B. W., GRENIER-BOLEY, B., SIMS, R., BIS, J. C., DAMOTTE, V., NAJ, A. C., BOLAND, A., VRONSKAYA, M., VAN DER LEE, S. J., AMLIE-WOLF, A., BELLENGUEZ, C., FRIZATTI, A., CHOURAKI, V., MARTIN, E. R., SLEEGERS, K., BADARINARAYAN, N., JAKOBSDOTTIR, J., HAMILTON-NELSON, K. L., MORENO-GRAU, S., OLASO, R., RAYBOULD, R., CHEN, Y., KUZMA, A. B., HILTUNEN, M., MORGAN, T., AHMAD, S., VARDARAJAN, B. N., EPELBAUM, J., HOFFMANN, P., BOADA, M., BEECHAM, G. W., GARNIER, J. G., HAROLD, D., FITZPATRICK, A. L., VALLADARES, O., MOUTET, M. L., GERRISH, A., SMITH, A. V., QU, L., BACQ, D., DENNING, N., JIAN, X., ZHAO, Y., DEL ZOMPO, M., FOX, N. C., CHOI, S. H., MATEO, I., HUGHES, J. T., ADAMS, H. H., MALAMON, J., SANCHEZ-GARCIA, F., PATEL, Y., BRODY, J. A., DOMBROSKI, B. A., NARANJO, M. C. D., DANIILIDOU, M., EIRIKSDOTTIR, G., MUKHERJEE, S., WALLON, D., UPHILL, J., ASPELUND, T., CANTWELL, L. B., GARZIA, F., GALIMBERTI, D., HOFER, E., BUTKIEWICZ, M., FIN, B., SCARPINI, E., SARNOWSKI, C., BUSH, W. S., MESLAGE, S., KORNHUBER, J., WHITE, C. C., SONG, Y., BARBER, R. C., ENGELBORGHS, S., SORDON, S., VOIJNOVIC, D., ADAMS, P. M., VANDENBERGHE, R., MAYHAUS, M., CUPPLES, L. A., ALBERT, M. S., DE DEYN, P. P., GU, W., HIMALI, J. J., BEEKLY, D., SQUASSINA, A., HARTMANN, A. M., ORELLANA, A., BLACKER, D., RODRIGUEZ-RODRIGUEZ, E., LOVESTONE, S., GARCIA, M. E., DOODY, R. S., MUNOZ-FERNADEZ, C., SUSSAMS, R., LIN, H., FAIRCHILD, T. J., BENITO, Y. A., HOLMES, C., KARAMUJIC-COMIC, H., FROSCH, M. P., THONBERG, H., MAIER, W., ROSCHUPKIN, G., GHETTI, B., GIEDRAITIS, V., KAWALIA, A., LI, S., HUEBINGER, R. M., KILANDER, L., MOEBUS, S., HERNANDEZ, I., KAMBOH, M. I., BRUNDIN, R., TURTON, J., YANG, Q., KATZ, M. J., CONCARI, L., LORD, J., BEISER, A. S., KEENE, C. D., HELISALMI, S., KLOSZEWSKA, I., KUKULL, W. A., KOIVISTO, A. M., LYNCH, A., TARRAGA, L., LARSON, E. B., HAAPASALO, A., LAWLOR, B., MOSLEY, T. H., LIPTON, R. B., SOLFRIZZI, V., GILL, M., LONGSTRETH, W. T. Jr., MONTINE, T. J., FRISARDI, V., DIEZ-FAIREN, M., RIVADENEIRA, F., PETERSEN, R. C., DERAMECOURT, V., ALVAREZ, I., SALANI, F., CIARAMELLA, A., BOERWINKLE, E., REIMAN, E. M., FIEVET, N., ROTTER, J. I., REISCH, J. S., HANON, O., CUPIDI, C., ANDRE UITTERLINDEN, A. G., ROYALL, D. R., DUFOUIL, Carole, MALETTA, R. G., DE ROJAS, I., SANO, M., BRICE, A., CECCHETTI, R., GEORGE-HYSLOP, P. S., RITCHIE, K., TSOLAKI, M., TSUANG, D. W., DUBOIS, B., CRAIG, D., WU, C. K., SOININEN, H., AVRAMIDOU, D., ALBIN, R. L., FRATIGLIONI, L., GERMANOU, A., APOSTOLOVA, L. G., KELLER, L., KOUTROUMANI, M., ARNOLD, S. E., PANZA, F., GKATZIMA, O., ASTHANA, S., HANNEQUIN, D., WHITEHEAD, P., ATWOOD, C. S., CAFFARRA, P., HAMPEL, H., QUINTELA, I., CARRACEDO, A., LANNFELT, L., RUBINSZTEIN, D. C., BARNES, L. L., PASQUIER, F., FROLICH, L., BARRAL, S., MCGUINNESS, B., BEACH, T. G., JOHNSTON, J. A., BECKER, J. T., PASSMORE, P., BIGIO, E. H., SCHOTT, J. M., BIRD, T. D., WARREN, J. D., BOEVE, B. F., LUPTON, M. K., BOWEN, J. D., PROITSI, P., BOXER, A., POWELL, J. F., BURKE, J. R., KAUWE, J. S. K., BURNS, J. M., MANCUSO, M., BUXBAUM, J. D., BONUCCELLI, U., CAIRNS, N. J., MCQUILLIN, A., CAO, C., LIVINGSTON, G., CARLSON, C. S., BASS, N. J., CARLSSON, C. M., HARDY, J., CARNEY, R. M., BRAS, J., CARRASQUILLO, M. M., GUERREIRO, R., ALLEN, M., CHUI, H. C., FISHER, E., MASULLO, C., CROCCO, E. A., DECARLI, C., BISCEGLIO, G., DICK, M., MA, L., DUARA, R., GRAFF-RADFORD, N. R., EVANS, D. A., HODGES, A., FABER, K. M., SCHERER, M., FALLON, K. B., RIEMENSCHNEIDER, M., FARDO, D. W., HEUN, R., FARLOW, M. R., KOLSCH, H., FERRIS, S., LEBER, M., FOROUD, T. M., HEUSER, I., GALASKO, D. R., GIEGLING, I., GEARING, M., HULL, M., GESCHWIND, D. H., GILBERT, J. R., MORRIS, J., GREEN, R. C., MAYO, K., GROWDON, J. H., FEULNER, T., HAMILTON, R. L., HARRELL, L. E., DRICHEL, D., HONIG, L. S., CUSHION, T. D., HUENTELMAN, M. J., HOLLINGWORTH, P., HULETTE, C. M., HYMAN, B. T., MARSHALL, R., JARVIK, G. P., MEGGY, A., ABNER, E., MENZIES, G. E., JIN, L. W., LEONENKO, G., REAL, L. M., JUN, G. R., BALDWIN, C. T., GROZEVA, D., KARYDAS, A., RUSSO, G., KAYE, J. A., KIM, R., JESSEN, F., KOWALL, N. W., VELLAS, B., KRAMER, J. H., VARDY, E., LAFERLA, F. M., JOCKEL, K. H., LAH, J. J., DICHGANS, M., LEVERENZ, J. B., MANN, D., LEVEY, A. I., PICKERING-BROWN, S., LIEBERMAN, A. P., KLOPP, N., LUNETTA, K. L., WICHMANN, H. E., LYKETSOS, C. G., MORGAN, K., MARSON, D. C., BROWN, K., MARTINIUK, F., MEDWAY, C., MASH, D. C., NOTHEN, M. M., MASLIAH, E., HOOPER, N. M., MCCORMICK, W. C., DANIELE, A., MCCURRY, S. M., BAYER, A., MCDAVID, A. N., GALLACHER, J., MCKEE, A. C., VAN DEN BUSSCHE, H., MESULAM, M., BRAYNE, C., MILLER, B. L., RIEDEL-HELLER, S., MILLER, C. A., MILLER, J. W., AL-CHALABI, A., MORRIS, J. C., SHAW, C. E., MYERS, A. J., WILTFANG, J., O'BRYANT, S., OLICHNEY, J. M., ALVAREZ, V., PARISI, J. E., SINGLETON, A. B., PAULSON, H. L., COLLINGE, J., PERRY, W. R., MEAD, S., PESKIND, E., CRIBBS, D. H., ROSSOR, M., PIERCE, A., RYAN, N. S., POON, W. W., NACMIAS, B., POTTER, H., SORBI, S., QUINN, J. F., SACCHINELLI, E., RAJ, A., SPALLETTA, G., RASKIND, M., CALTAGIRONE, C., BOSSU, P., ORFEI, M. D., REISBERG, B., CLARKE, R., REITZ, C., SMITH, A. D., RINGMAN, J. M., WARDEN, D., ROBERSON, E. D., WILCOCK, G., ROGAEVA, E., BRUNI, A. C., ROSEN, H. J., GALLO, M., ROSENBERG, R. N., BEN-SHLOMO, Y., SAGER, M. A., MECOCCI, P., SAYKIN, A. J., PASTOR, P., CUCCARO, M. L., VANCE, J. M., SCHNEIDER, J. A., SCHNEIDER, L. S., SLIFER, S., SEELEY, W. W., SMITH, A. G., SONNEN, J. A., SPINA, S., STERN, R. A., SWERDLOW, R. H., TANG, M., TANZI, R. E., TROJANOWSKI, J. Q., TRONCOSO, J. C., VAN DEERLIN, V. M., VAN ELDIK, L. J., VINTERS, H. V., VONSATTEL, J. P., WEINTRAUB, S., WELSH-BOHMER, K. A., WILHELMSEN, K. C., WILLIAMSON, J., WINGO, T. S., WOLTJER, R. L., WRIGHT, C. B., YU, C. E., YU, L., SABA, Y., ALZHEIMER DISEASE GENETICS, Consortium, EUROPEAN ALZHEIMER'S DISEASE, Initiative, COHORTS FOR, Heart, AGING RESEARCH IN GENOMIC EPIDEMIOLOGY, Consortium, GENETIC ENVIRONMENTAL RISK IN AD/DEFINING GENETIC, Polygenic, ENVIRONMENTAL RISK FOR ALZHEIMER'S DISEASE, Consortium, PILOTTO, A., BULLIDO, M. J., PETERS, O., CRANE, P. K., BENNETT, D., BOSCO, P., COTO, E., BOCCARDI, V., DE JAGER, P. L., LLEO, A., WARNER, N., LOPEZ, O. L., INGELSSON, M., DELOUKAS, P., CRUCHAGA, C., GRAFF, C., GWILLIAM, R., FORNAGE, M., GOATE, A. M., SANCHEZ-JUAN, P., KEHOE, P. G., AMIN, N., ERTEKIN-TANER, N., BERR, C., DEBETTE, Stephanie, LOVE, S., LAUNER, L. J., YOUNKIN, S. G., DARTIGUES, Jean-Francois, CORCORAN, C., IKRAM, M. A., DICKSON, D. W., NICOLAS, G., CAMPION, D., TSCHANZ, J., SCHMIDT, H., HAKONARSON, H., CLARIMON, J., MUNGER, R., SCHMIDT, R., FARRER, L. A., VAN BROECKHOVEN, C., M, C. O' Donovan, DESTEFANO, A. L., JONES, L., HAINES, J. L., DELEUZE, J. F., OWEN, M. J., GUDNASON, V., MAYEUX, R., ESCOTT-PRICE, V., PSATY, B. M., RAMIREZ, A., WANG, L. S., RUIZ, A., VAN DUIJN, C. M., HOLMANS, P. A., SESHADRI, S., WILLIAMS, J., AMOUYEL, P., SCHELLENBERG, G. D., LAMBERT, J. C., PERICAK-VANCE, M. A., Epidemiology, Internal Medicine, Neurology, Radiology & Nuclear Medicine, Amsterdam Reproduction & Development (AR&D), Clinical sciences, Pathologic Biochemistry and Physiology, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Medizin, Gene Expression, genetics [Alzheimer Disease], Genome-wide association study, methods [Genome-Wide Association Study], SEPIA, Genome-wide association studies, genetic meta-analysis, 0302 clinical medicine, genetics [Immunity], genetics [Amyloid beta-Peptides], genetics, tau, genetics [Genetic Predisposition to Disease], new risk loci, Aβ, Genetics, Medicine(all), 0303 health sciences, medicine.diagnostic_test, Alzheimer's disease, Lipids, 3. Good health, Settore MED/26 - NEUROLOGIA, VINTAGE, Female, Amyloid beta, methods [Genetic Testing], Tau protein, lipid processing, tau Proteins, genetics [Genetic Loci], Biology, Article, FR, 03 medical and health sciences, Alzheimer Disease, ddc:570, genetics [Haplotypes], medicine, Genetic predisposition, Humans, Dementia, Genetic Predisposition to Disease, Genetic Testing, LOAD, genetics [Lipids], Risk factor, immunity, Aged, 030304 developmental biology, Genetic testing, Amyloid beta-Peptides, Lipid Metabolism, medicine.disease, Gene expression, genetics [tau Proteins], Haplotypes, Genetic Loci, Case-Control Studies, genetics [Lipid Metabolism], genome-wide association studies, biology.protein, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, 030217 neurology & neurosurgery, Genome-Wide Association Study, dementia
Abstract: Risk for late-onset Alzheimers disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimers or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimers disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 ׫2009»10−7), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education.
Published: 2019

18. CHALLENGING AGEIST ATTITUDES FOR ALL INTENTS AND PURPOSES: A MIXED METHODS ANALYSIS

Author: Whitley L, Keisha D. Carden, Popp T, Sarah K. Letang, Rebecca S. Allen, Choi J, Hull M, and Daniel C. Potts
Subjects: Abstracts, Health (social science), Computer science, Life-span and Life-course Studies, Health Professions (miscellaneous), Data science, Mixed methods analysis
Abstract: Service learning programs, such as Bringing Art to Life (BATL), are designed to address ageist attitudes by bolstering empathetic intergenerational relationships, creating a comprehensive, realistic view of aging, and fostering positive attitudes towards older adults. This project examined learning outcomes for students enrolled in an experiential University of Alabama Honors College course (BATL), wherein students work directly with persons with dementia (PWD) to produce a life story incorporating art. Students completed electronic surveys measuring empathy, mindfulness, and attitudes toward older adults generally, individuals with dementia, and interest in community service. A series of within-subjects analyses of covariance revealed increases in empathy and improved attitudes toward older adults and PWD. Students also kept journals documenting their experiences. In a sequential mixed methods design, a qualitative phase II follow-up explanations model (Creswell et. al., 2003) was employed to explain and expand on quantitative results. Student participant journals were collected, a codebook and coding system was developed, and four coders utilized an iterative hermeneutic coding process to enhance inter-rater reliability. Overall, the integrated mixed-methods results provide evidence for the mechanisms that facilitate the change in students’ attitudes. Specifically, existential awareness fosters mindfulness and empathy that subsequently facilitates change in ageist attitudes generally. Moreover, meaningful engagement with the present moment with other group members versus meaningful engagement with art was a more powerful predictor of intergenerational relationship building, conversations regarding purpose- and meaning-in-life, and subsequent shifts in ageist attitudes.
Published: 2018

19. The EURO-FORTA (Fit fOR The Aged) List: International Consensus Validation of a Clinical Tool for Improved Drug Treatment in Older People

Author: Pazan, F., Weiss, C., Wehling, M., Burkhardt, H., Schwarz, S., Wedding, U., Johnell, K., Eriksson, T., Ruths, S., Husebo, B. S., Huupponen, R., Ranhoff, A. H., Onder, G., Incalzi, R. A., Marcucci, M., Cherubini, A., Volpato, S., Ruggiero, C., Mugelli, A., Laville, M., Annweiler, C., Mouchoux, C., Robert, P., Rhalimi, M., Jaurrieta, J. J. S., Manas, L. R., Nunez, J. F. M., Jentoft, A. J. C., Rexach, J. A. S., Agusti, A., Mateos, R., Laporte, A. S. -J., Gladman, J., Crome, P., Hughes, C., O'Mahony, D., Byrne, S., Ekpo, E., Ashton, C., Witham, M. D., Soiza, R. L., Wieczorowska-Tobis, K., Kostka, T., Slawek, J., Klich-Raczka, A., Grodzicki, T., Bien, B., Broncel, M., Mierzejewski, P., Jansen, R. W. M. M., van den Bemt, P. M. L. A., van der Cammen, T. J. M., Bauer, J., Berthold, H. K., Denkinger, M., Dovjak, P., Frohnhofen, H., Fruhwald, T., Gisinger, C., Gogol, M., Gosch, M., Gutzmann, H., Heuser, I., Hull, M., Iglseder, B., Kasper, S., Kwetkat, A., von Renteln-Kruse, W., Schindler, C., Schuler, M., Schulz, R. J., Sommeregger, U., and Zeyfang, A.
Subjects: medicine.medical_specialty, Consensus, Delphi Technique, Acknowledgement, Pharmacology toxicology, Delphi method, MEDLINE, 03 medical and health sciences, Drug treatment, 0302 clinical medicine, Drug Therapy, Geriatric Assessment/methods, Age Factors, Aged, Consensus, Delphi Technique, Drug Therapy/methods, Europe, Geriatric Assessment/methods, Humans, Polypharmacy, Prospective Studies, Reproducibility of Results, medicine, Humans, Pharmacology (medical), Drug Therapy/methods, 030212 general & internal medicine, Prospective Studies, Geriatric Assessment, Aged, Polypharmacy, Geriatrics gerontology, business.industry, Age Factors, Reproducibility of Results, Europe, Family medicine, Geriatrics and Gerontology, Older people, business, 030217 neurology & neurosurgery
Abstract: Drug treatment of older people is still potentially inappropriate in many cases as multimorbidity and related polypharmacy are highly prevalent. To increase the quality of drug treatment in older people, the FORTA (Fit fOR The Aged) List (first version 2012) was developed in a Delphi consensus procedure and updated (FORTA2015) by 21 experts from Germany and Austria. It has been validated in a randomized, controlled, prospective trial demonstrating significant improvement in the quality of drug treatment and clinical endpoints (VALFORTA).Based on these results, Delphi consensus validations (two rounds) of country/region-specific FORTA Lists were conducted in the UK/Ireland, France, Poland, Italy, Spain, the Nordic countries and The Netherlands. An algorithm based on geriatric/pharmacologic expertise, publications and professional position was used to find experts in the field.Forty-seven experts agreed to participate in the Delphi process (return rate of 97.9%). For each country/region, the overall mean consensus coefficient (deviation from the initiator proposal) was 0.9. FORTA Lists from six countries/regions with a minimum of four participating experts (excluding The Netherlands) plus the original FORTA List were collated into the EURO-FORTA List containing 264 items in 26 main indication groups. Two drugs had to be added to the proposed items, as proposed by at least four countries/regions; none had to be removed.This project produced seven new country/region-specific FORTA Lists, as well as the overarching EURO-FORTA List showing a high consensual level based on a broader expert base. EURO-FORTA should help to spread the FORTA approach and improve geriatric pharmacotherapy internationally.
Published: 2018

20. Bialellic Mutations in Tetratricopeptide Repeat Domain 7A (TTC7A) Cause Common Variable Immunodeficiency-Like Phenotype with Enteropathy

Author: Lawless, D, Mistry, A, Wood, PM, Stahlschmidt, J, Arumugakani, G, Hull, M, Parry, D, Anwar, R, Carter, C, and Savic, S
Subjects: macromolecular substances
Abstract: TTC7A deficiency typically causes severe gastrointestinal manifestations such as multiple intestinal atresia or early-onset inflammatory bowel disease. In some cases, this is associated with severe combined immunodeficiency. Partial loss-of-function mutations appear to be associated with a milder phenotype resulting in common variable immunodeficiency-like condition with enteropathy.
Published: 2017

21. Research Priorities for Endometriosis

Author: Rogers, Peter AW, Adamson, G David, Al-Jefout, Moamar, Becker, Christian M, D'Hooghe, Thomas M, Dunselman, Gerard AJ, Fazleabas, Asgerally, Giudice, Linda C, Horne, Andrew W, Hull, M Louise, Hummelshoj, Lone, Missmer, Stacey A, Montgomery, Grant W, Stratton, Pamela, Taylor, Robert N, Rombauts, Luk, Saunders, Philippa T, Vincent, Katy, Zondervan, Krina T, and WES/WERF Consortium for Research Priorities in Endometriosis
Subjects: endometriosis, Conference Paper, Consensus, workshop, female infertility, disease classification, ovary follicle development, Education, Paediatrics and Reproductive Medicine, lowest income group, genomics, infertility therapy, Humans, genetics, pain, human, oocyte, Obstetrics & Reproductive Medicine, pathophysiology, symptom assessment, pregnancy outcome, research, consensus report, epigenetics, Contraception/Reproduction, pathogenesis, international workshop, embryo development, biological marker, research priority, female, research priorities, priority journal, health care policy, WES/WERF Consortium for Research Priorities in Endometriosis, prognosis
Abstract: The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17-20, 2017, in Vancouver, British Columbia, Canada.
Published: 2017

22. A finitely generated group that does not satisfy the generalized Burghelea Conjecture

Author: Dranishnikov, A. and Hull, M.
Subjects: Mathematics - Geometric Topology, Mathematics::K-Theory and Homology, Mathematics - K-Theory and Homology, FOS: Mathematics, Algebraic Topology (math.AT), K-Theory and Homology (math.KT), Geometric Topology (math.GT), Mathematics - Algebraic Topology, Group Theory (math.GR), Mathematics::Spectral Theory, Mathematics - Group Theory, Mathematics::Algebraic Topology
Abstract: We construct a finitely generated group that does not satisfy the generalized Burghelea conjecture.
Published: 2017
Full Text: View/download PDF

23. CLASP - A RANDOMIZED TRIAL OF LOW-DOSE ASPIRIN FOR THE PREVENTION AND TREATMENT OF PREECLAMPSIA AMONG 9364 PREGNANT-WOMEN

Author: BEROYZ, G, CASALE, R, FARREIROS, A, PALERMO, M, MARGULIES, M, VOTO, L, FABREGUES, G, RAMALINGAM, R, DAVIES, T, BRYCE, R, BOYD, W, CARMODY, F, KING, J, VACCA, A, FAY, R, WALTERS, W, ANTONAS, B, BENNETT, P, BROOM, T, CROWTHER, C, DERHAM, R, GEORGE, K, HAGUE, W, HASENHOHR, G, HEYSEN, D, KORNMAN, L, OLOUGHLIN, S, MORRIS, D, PRIDMORE, B, ROBINSON, J, SVIGOS, D, SWEET, R, BEALE, M, BENNETT, M, BOSCH, E, FISHER, C, HORRAUTZ, S, SYMINGTON, I, SZIRT, A, FORBES, K, FREEMAN, A, POPPER, E, WILSON, J, PERMEZEL, M, BOWDITCH, J, REYNOLDS, G, MOULINASSE, R, BIETLOT, Y, KIRKPATRICK, C, COULON, R, DELVOYE, P, DEMATOS, C, SIMONINI, S, LEJEUNE, B, NEERDAELS, C, ALEXANDER, S, GOESSENS, L, HANSSENS, M, SPITZ, B, VANASSCHE, A, WECKHUYSEN, R, PARBOOSINGH, J, HARMAN, C, REY, E, BURROWS, R, BELCHER, J, GARNER, P, SYLVAIN, J, NIMROD, C, THOMAS, B, DEININGER, F, LAO, T, LI, C, FRIEDMAN, S, BORNSTEIN, J, SHALIT, A, MATZKEL, A, POMERANZ, M, GELSNER, M, MANKUTA, D, WIZNITZER, A, LEVINE, S, ADEEB, N, CHANDRAN, R, NASRI, N, SHARIFF, J, ANSELL, D, LAKE, Y, GOROCHOVA, L, MERIAKRI, V, ROMANUGA, N, DOTZ, I, SHEUV, B, VIKHLYAEVA, E, ANDREEV, K, GOLUBEVA, L, GORODCOV, V, ADELANTADO, J, SANTONJA, J, HOLMBERG, H, BUCHHAVE, P, LEANDERSSON, U, LILJESTRAND, J, RYDHSTROEM, H, SWEDIN, G, BJORKLUND, A, GENNSER, G, SANDEN, M, DAHLGREN, S, HAMMARBACK, S, SMEDS, A, SIDENVALL, M, ENEROTH, E, SZABOLCS, A, DANIELSSON, I, LINDQVIST, P, HOGSTEDT, S, WALLENBURG, H, BREMER, H, BRIET, J, DEBIEMEYERINK, A, DONKERS, B, LAMPING, P, SCHIERBEEK, J, VANDERLEEUWHARMSEN, L, THE, H, VANBODEGOM, F, VANEGMONDLINDEN, A, FLU, P, KUIJKEN, J, MORREL, B, STRAUB, M, VIERHOUT, M, KEIRSE, M, VANROOSMALEN, J, HOHNER, C, HUTTEN, J, BENNEN, J, ROEX, A, WIJFFELS, T, OOSTERHOFF, H, OTTEN, J, VANDERKLEI, T, RAMONDT, J, VANDERMOER, P, DEGRAAFF, J, SIJSMA, E, DEGREVE, O, SMIT, D, SMULDERS, P, NIJHUIS, J, ZONDERVAN, H, LIND, J, SCHOOT, B, MONKHORST, M, STUT, J, VANDAM, L, VANOTTERLO, L, VLAANDEREN, W, EGGENS, J, SANTEMA, J, VERHOEFF, A, HAMID, S, JOHN, I, KHAN, G, SHAH, S, SHEIKH, E, SINHA, C, ABRAMOVICH, D, CAMPBELL, D, FISHER, P, GALL, S, HALL, M, JANDIAL, V, PARKIN, D, SMITH, N, SUTHERLAND, H, SWAPP, G, TEMPLETON, A, TERRY, P, KALAM, A, MAGEE, S, MARTIN, D, SPEARING, G, ALDERMAN, B, MURRAY, A, SUTHERST, J, HYATT, D, SAUNDERS, P, BURGESS, S, COCHRANE, G, WHITE, A, ARMSTRONG, M, MCNICHOL, E, OSBOURNE, G, PRICE, J, CRICHTON, J, EVANS, D, ANDERSON, R, HULL, M, JAMES, D, NIVEN, P, STIRRAT, G, WARDLE, P, GARDNER, P, PADGETT, L, ALAILY, A, NASH, G, GINZ, B, SMITH, M, RICHARDS, C, ARMAR, A, ARMSTRONG, N, MANNING, E, PERSAD, K, COLLINGWOOD, M, COLLINS, R, CROWTHER, J, FARRELL, B, HAFNER, B, HANDOLL, H, HEINEMAN, J, KNIGHT, S, MEAD, G, RADLEY, A, SPENCE, S, REID, W, TREHARNE, I, HEASLEY, R, LOWRY, D, MYLES, T, WALLACE, R, GEALS, M, GORDON, G, TRAIN, T, HUTCHON, D, MACDONALD, J, STOREY, R, ANDERSON, G, WORTH, R, ERIAN, J, MCQUEEN, J, TATFORD, E, TERRY, M, NEALE, R, HOWAT, R, KENNEDY, J, MACNAUGHTON, M, MCEWAN, H, WALKER, J, HUTCHESON, R, KEMP, V, READ, M, SIMMS, M, SWINGLER, G, HUSEMEYER, R, CHAPMAN, M, MAXWELL, D, ELDER, M, FUSI, L, HAWKINS, D, NICOLINI, U, WINSTON, R, BURTON, E, FAIRBANK, J, SIMMONS, S, SPING, J, TRICKEY, N, GILLARD, M, HUDSON, C, SETCHELL, M, WATHEN, N, CANTY, S, WHITELEY, P, CAMPBELL, J, FEENEY, J, HAY, D, IMRIE, A, PALMER, A, PURDIE, D, SPECK, E, TYRRELL, S, MCLEAN, J, BROWN, V, DUNCAN, S, JOHNSON, D, MILLAR, D, BUCKLEY, D, CHARNOCK, M, DOVE, P, ELLIS, J, GILLMER, M, MCVITTIE, J, MANNION, V, REDMAN, C, SELLERS, S, TURNBULL, A, NEWMAN, M, CAMPBELL, S, CARDOSO, L, GIBB, D, HARRINGTON, K, PARSONS, J, NICOLAIDES, K, STUDD, J, DIXON, R, GIE, C, PICKLES, C, SEAR, R, GRAHAM, R, KIRWAN, P, SMITH, G, ANWAR, M, ALAZZAWI, F, DAVIDSON, A, DECHAZEL, R, DRIFE, J, GILL, F, LANG, G, MACAFEE, J, MACVICAR, J, NAFTALIN, N, NEUBERG, R, TAYLOR, D, LEAVER, E, TIMOTHY, I, BREESON, A, LAMB, M, VELACOTT, I, VERNER, V, HORWELL, D, LOBB, M, SELIGMAN, S, SCOTT, A, HALL, S, MACKENZIE, W, SMITH, E, VETHANAVAGAN, S, VERZIN, J, WEIR, P, WHITE, R, CLARK, H, FAWDRY, R, LYNCH, C, MCCUNE, G, BOWENSIMPKINS, P, CALVERT, J, EMERY, S, JACKSON, W, STOKES, I, WARD, A, BROWNING, A, COX, C, LITTLE, D, STIBBE, H, MCINTOSH, A, SNODGRASS, C, WAGSTAFF, T, HOWIE, P, BIBBY, J, DAVIES, W, ELLIOTT, B, SHAXTED, E, MCGARRY, J, DAW, E, BAKER, K, CLUBB, A, GOUGH, J, GRANT, M, MENON, V, OBHARI, M, OBRIEN, P, BROWN, R, RYALL, A, WALTON, S, BAKER, J, BRUCE, J, LIU, D, JOHNSON, I, TYACK, A, COWIE, D, NYSENBAUM, A, BAMFORD, P, GARRIOCH, D, HILL, J, GRANT, A, FELTON, D, HACKMAN, B, FALCONER, A, FREEMAN, F, GREENE, K, JACKSON, J, HUNTER, G, GRATTON, D, MAULIK, T, YOUSSEF, H, BANWELL, G, HARTWELL, R, WILSON, P, BOND, A, FORBESSMITH, P, BARRON, L, DAVISON, J, DUNLOP, W, LIND, T, TACCHI, D, BALFOUR, R, MUTCH, L, COLTART, T, DESWIET, M, EDMONDS, D, LOEFFLER, F, MALVERN, J, OSBOURNE, J, RODECK, C, SIMS, C, SPENCER, J, BONE, C, MACDONALD, A, DREW, N, BALLARD, R, THONET, R, HANNA, L, MORCOS, S, HOLT, E, COOPER, J, CALLEN, P, FOZZARD, C, GRUNDY, M, STANLEY, S, DANIEL, D, GOLDING, R, WIENER, J, BUCKINGHAM, M, HEARD, M, LETCHWORTH, A, BOOMLA, K, CLARK, A, GRUDZINSKAS, J, HARTGILL, J, ORAM, D, ROBSON, J, SAVAGE, W, BLUNT, V, LANE, J, OWEN, A, REDFORD, D, BEARD, R, BOSTOCK, J, MEASDAY, B, MELVILLE, H, DORNAN, J, TRAUB, A, UTIDJIAN, M, AULD, A, KRASZEWSKI, A, MACK, D, MCDOUGALL, N, MOWAT, J, DOCHERTY, P, MCKENNA, D, SMEDLEY, G, WILDE, J, SMITH, R, WATNEY, P, MCDONNELL, J, TROMAMS, P, CALDER, A, GLASIER, A, GREER, I, JOHNSTONE, F, LISTON, W, LIVINGSTONE, J, NEILSON, J, SMITH, S, WEST, C, BULLOUGH, C, JONES, A, MACKAY, G, COOPER, K, RUOSS, C, JOYCE, D, MCCOY, D, MCLEOD, F, SAVAGE, P, SMITH, P, TURNER, G, KANE, L, ROSENBERG, D, SHANNON, R, BROMHAM, D, BUCHAN, P, CROMPTON, A, JARVIS, G, LILFORD, R, MACDONALD, H, THORNTON, J, PINKER, G, BEVAN, J, FRANCIS, J, KETTLE, M, HOLMES, H, KERRWILSON, R, SUTTON, M, BEYNON, J, HOOKER, J, FERGUSSON, I, MORTON, K, TAYLOR, R, DAVIS, J, LOW, R, STEWART, J, ASHWORTH, F, SOONAWALLA, K, TEBBUTT, I, USHERWOOD, M, VOIGT, J, COHEN, S, GODFREY, K, MCNAB, G, MURRAY, B, GUDGEON, D, FOULKES, J, STANNARD, P, JAMSHIDI, R, MULHOLLAND, J, BOND, E, DUNLOP, J, FOGARTY, P, BRANT, H, LACHELIN, L, LLOYDJONES, R, SIDDLE, N, SILVERSTONE, A, STEELE, S, WARD, R, EDDIE, D, VERNONPARRY, J, CIETAK, K, KENNEDY, C, REED, M, SANTCASSIA, L, BEGG, H, FRAMPTON, J, GRIFFIN, D, LEWIS, B, NESTROP, A, SHERIDAN, R, TIPTON, R, BOBER, S, BROUGH, F, STAFFORD, J, HOUSE, M, PAWSON, M, REES, D, VENN, R, ANDERSON, T, HUGHES, J, REGINALD, P, HENSON, G, MORGAN, H, ALLEN, I, HANNAY, W, LENNOX, C, CALLENDER, R, MCLEAN, R, GOLDKRAND, J, and FIDALGO, C
Subjects: medicine.medical_specialty, Randomized controlled trial, law, business.industry, Internal medicine, medicine, General Medicine, medicine.disease, business, law.invention, Preeclampsia, Low dose aspirin
Published: 2016

24. Fractional anisotropy changes in Alzheimer's disease depend on the underlying fiber tract architecture: a multiparametric DTI study using joint independent component analysis

Author: Teipel SJ, Grothe MJ, Filippi M, Fellgiebel A, Dyrba M, Frisoni GB, Meindl T, Bokde ALW, Hampel H, Klöppel S, Hauenstein K, the EDSD study group, Agosta F, Barkhof F, Blautzik J, Bokde AL, Ewers M, Fischer F, Frolich L, Hausner L, Hentschel F, Hull M, Jessen F, Kljajevic V, Kloppel S, O'Dwyer L, Pievani M, Pouwels PJ, Teipel, Sj, Grothe, Mj, Filippi, M, Fellgiebel, A, Dyrba, M, Frisoni, Gb, Meindl, T, Bokde, Alw, Hampel, H, Klöppel, S, Hauenstein, K, the EDSD study, Group, Agosta, F, Barkhof, F, Blautzik, J, Bokde, Al, Ewers, M, Fischer, F, Frolich, L, Hausner, L, Hentschel, F, Hull, M, Jessen, F, Kljajevic, V, Kloppel, S, O'Dwyer, L, Pievani, M, and Pouwels, Pj
Subjects: Male, White Matter/pathology, pathology [Cognitive Dysfunction], pathology [Pyramidal Tracts], Alzheimer Disease/diagnosis/pathology, Pyramidal Tracts, Nerve Fibers, Myelinated, methods [Diffusion Tensor Imaging], pathology [Alzheimer Disease], ddc:616.89, pathology [Brain], methods [Image Processing, Computer-Assisted], pathology [White Matter], methods [Diffusion Magnetic Resonance Imaging], Image Processing, Computer-Assisted, Anisotropy, Nerve Degeneration/pathology, pathology [Axons], General Neuroscience, diagnosis [Alzheimer Disease], pathology [Nerve Degeneration], Brain, General Medicine, White Matter, Pyramidal Tracts/pathology, Diffusion Magnetic Resonance Imaging/methods, Europe, Psychiatry and Mental health, Clinical Psychology, medicine.anatomical_structure, Diffusion Tensor Imaging, Disease Progression, Female, Psychology, Image Processing, Computer-Assisted/methods, Fiber tract, White matter, Alzheimer Disease, Diffusion Tensor Imaging/methods, Fractional anisotropy, mental disorders, medicine, Dementia, Humans, Cognitive Dysfunction, Brain/pathology, ddc:610, Aged, Nerve Fibers, Myelinated/pathology, pathology [Nerve Fibers, Myelinated], Mild Cognitive Impairment/diagnosis/pathology, medicine.disease, Independent component analysis, Axons, Diffusion Magnetic Resonance Imaging, Axons/pathology, Early Diagnosis, diagnosis [Cognitive Dysfunction], Corticospinal tract, Nerve Degeneration, Geriatrics and Gerontology, Neuroscience, Diffusion MRI
Abstract: Diffusion tensor imaging (DTI) allows the simultaneous measurement of several diffusion indices that provide complementary information on the substrate of white matter alterations in neurodegenerative diseases. These indices include fractional anisotropy (FA) as measure of fiber tract integrity, and the mode of anisotropy (Mode) reflecting differences in the shape of the diffusion tensor. We used a multivariate approach based on joint independent component analysis of FA and Mode in a large sample of 138 subjects with Alzheimer's disease (AD) dementia, 37 subjects with cerebrospinal fluid biomarker positive mild cognitive impairment (MCI-AD), and 153 healthy elderly controls from the European DTI Study on Dementia to comprehensively study alterations of microstructural white matter integrity in AD dementia and predementia AD. We found a parallel decrease of FA and Mode in intracortically projecting fiber tracts, and a parallel increase of FA and Mode in the corticospinal tract in AD patients compared to controls. Subjects with MCI-AD showed a similar, but spatially more restricted pattern of diffusion changes. Our findings suggest an early axonal degeneration in intracortical projecting fiber tracts in dementia and predementia stages of AD. An increase of Mode, parallel to an increase of FA, in the corticospinal tract suggests a more linear shape of diffusion due to loss of crossing fibers along relatively preserved cortico-petal and cortico-fugal fiber tracts in AD. Supporting this interpretation, we found three populations of fiber tracts, namely cortico-petal and cortico-fugal, commissural, and intrahemispherically projecting fiber tracts, in the peak area of parallel FA and Mode increase.
Published: 2014

25. The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease

Author: Kljajevic, V, Meyer, P, Holzmann, C, Dyrba, M, Kasper, E, Bokde, Al, Fellgiebel, A, Meindl, T, Hampel, H, Teipel, S, EDSD study group, Agosta, F, Barkhof, F, Blautzik, J, Ewers, M, Filippi, M, Fischer, F, Frisoni, Gb, Frolich, L, Hauenstein, K, Hausner, L, Hentschel, F, Hull, M, Jessen, F, Kloppel, S, O'Dwyer, L, Pievani, M, Pouwels, Pj, Teipel, Sj, Kljajevic, V, Meyer, P, Holzmann, C, Dyrba, M, Kasper, E, Bokde, Al, Fellgiebel, A, Meindl, T, Hampel, H, Teipel, S, EDSD study, Group, Agosta, F, Barkhof, F, Blautzik, J, Ewers, M, Filippi, M, Fischer, F, Frisoni, Gb, Frolich, L, Hauenstein, K, Hausner, L, Hentschel, F, Hull, M, Jessen, F, Kloppel, S, O'Dwyer, L, Pievani, M, Pouwels, Pj, and Teipel, Sj
Subjects: Apolipoprotein E, Male, medicine.medical_specialty, Heterozygote, Genotype, Epidemiology, Apolipoprotein E4, genetics [Alzheimer Disease], Disease, White matter, Age and gender, Cellular and Molecular Neuroscience, pathology [Alzheimer Disease], Developmental Neuroscience, pathology [Brain], Alzheimer Disease, Internal medicine, pathology [White Matter], Fractional anisotropy, medicine, Humans, ddc:610, Allele, genetics [Apolipoprotein E4], Aged, Aged, 80 and over, Health Policy, Brain, Middle Aged, White Matter, Psychiatry and Mental health, Endocrinology, medicine.anatomical_structure, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Anisotropy, Female, Neurology (clinical), Geriatrics and Gerontology, Psychology, Neuroscience, Diffusion MRI
Abstract: In this multicenter study, we investigated a possible association between the APOE ε4 allele and white matter (WM) integrity in Alzheimer's disease (AD) using diffusion tensor imaging (DTI).We analyzed fractional anisotropy (FA) and mean diffusivity (MD) as indices of WM integrity in 70 AD patients (35 APOE ε4 carriers, 35 noncarriers) and 56 healthy control (HC) subjects (28 APOE ε4 carriers, 28 noncarriers). APOE ε4 carriers and noncarriers were matched for age and gender within each diagnostic group.We found significant effects of diagnosis (Pcorrected.05 [FWE]; i.e., smaller FA values and larger MD values in AD patients compared with HCs) and significant effects (P.001) of APOE ε4 carrier status on MD in HCs but not in AD subjects.The results indicate that APOE ε4 has a moderate effect on WM integrity in HCs, but no effect on WM integrity in manifest AD.
Published: 2014

26. Using innovative methods in trial identification for 12 Cochrane Intervention Reviews

Author: Noel-Storr, A, Ware, J, Gouda, P, Hull, M, Jackson, D, Murrieta Álvarez, I, Yaman, H, Forbes, S, and Rutjes, A
Published: 2015

27. Ein römischer Reitergrabstein aus Colchester

Author: Hull, M. R.
Abstract: [nicht vorhanden / not available]
Published: 2015
Full Text: View/download PDF

28. Recombinant Human Luteinizing Hormone is as effective as, but safer than urinary human chorionic gonadotropin in inducing final follicular maturation and ovulation in in vitro procedures: results of a multicenter double-blind study

Author: Engrand P, Arguinzoniz, Piazzi A, Loumaye E, Devroey P, Smith J, Andersen AN, Frydman, Hedon B, Hugues JN, Roulier R, Salat Baroux J, Homburg R, Shoham Z, Barash A, Palermo R, Flamigni C, Schoemaker J, Te Velde E. R, Braat D, Hamberger L, Germond M, Imthurn B, Barlow DH, Brisden P, Fleming R, Hull M, Lockwood G, Templeton A, Yates R., PORCU, ELEONORA, Engrand P, Arguinzoniz, Piazzi A, Loumaye E, Devroey P, Smith J, Andersen AN, Frydman, Hedon B, Hugues JN, Roulier R, Salat Baroux J, Homburg R, Shoham Z, Barash A, Palermo R, Flamigni C, Porcu E, Schoemaker J, Te Velde E R, Braat D, Hamberger L, Germond M, Imthurn B, Barlow DH, Brisden P, Fleming R, Hull M, Lockwood G, Templeton A, and Yates R
Subjects: Human gonadotropin, endocrine system, Human Luteinizing Hormone
Abstract: n a prospective, comparative, dose-finding study, the minimal effective dose of recombinant human LH (rhLH) required to induce final follicular maturation and early luteinization in patients undergoing in vitro fertilization and embryo transfer was determined. In addition, the efficacy and safety of rhLH were compared with urinary human CG (u-hCG). A total of 259 infertile women, aged 18-39 yr, were enrolled in the study. After pituitary desensitization using a GnRH agonist, rhFSH was administered for ovarian stimulation. Patients then received either rhLH or u-hCG to achieve final follicular maturation. The doses of rhLH administered were 5,000, 15,000, 30,000, or 15,000 + 10,000 IU (second injection administered 3 days after the first injection; 129 patients), and those of u-hCG were consistently 5,000 IU (121 patients). Ovum pick-up was performed 34--38 h after rhLH or u-hCG injection. After fertilization in vitro, up to three embryos were replaced in the uterine cavity. The numbers of oocytes retrieved after u-hCG or rhLH administration were not significantly different between the four different doses of rhLH, when compared with each corresponding u-hCG group, nor when compared with the pool of all u-hCG groups. Similarly, there were no statistically significant differences in: the number of oocytes retrieved per follicle with a diameter of over 10 mm on the day of u-hCG or rhLH administration; the number of patients with at least one oocyte retrieved; oocyte nuclear maturity; oocyte potential for fertilization; the number of embryos; the number of total, biochemical, and clinical pregnancies; and the embryo implantation rate. However, in many of these parameters, the lowest dose of rhLH seemed suboptimal when compared with the higher dose. In terms of safety, rhLH was well tolerated at a dose of up to 30,000 IU. Moderate ovarian hyperstimulation syndrome (OHSS) was reported in 12.4% of patients who received u-hCG and 12.0% of patients who received two injections of rhLH. No moderate or severe OHSS was reported in patients who received a single dose of rhLH up to 30,000 IU. The results show that a single dose of rhLH is effective in inducing final follicular maturation and early luteinization in in vitro fertilization and embryo transfer patients and is comparable with 5,000 IU u-hCG. A single dose of rhLH results in a highly significant reduction in OHSS compared with hCG. The dose of rhLH giving the highest efficacy to safety ratio was between 15,000 and 30,000 IU
Published: 2004

29. Dementia quality of life instrument--construct and concurrent validity in patients with mild to moderate dementia

Author: Voigt-Radloff, S., Leonhart, R., Schutzwohl, M., Jurjanz, L., Reuster, T., Gerner, A., Marschner, K., Nes, F. van, Graff, M.J., Vernooij-Dassen, M.J.F.J., Olde Rikkert, M.G., Holthoff, V., and Hull, M.
Subjects: Effective primary care and public health Aetiology, screening and detection [NCEBP 7], Alzheimer Centre [DCN PAC - Perception action and control NCEBP 11], Effective primary care and public health [NCEBP 7], Alzheimer Centre [NCEBP 11], Quality of hospital and integrated care [NCEBP 4]
Abstract: Item does not contain fulltext BACKGROUND AND PURPOSE: To translate the Dementia quality of life instrument (DQoL) into German and assess its construct and concurrent validity in community-dwelling people with mild to moderate dementia. METHODS: Dementia quality of life instrument data of two pooled samples (n=287) were analysed regarding ceiling and floor effects, internal consistency, factor reliability and correlations with corresponding scales on quality of life (Quality of Life in Alzheimer's Disease and SF-12), cognition (Mini-Mental State Examination, Alzheimer's Disease Assessment Scale - cognitive), depression (Cornell Scale for Depression in Dementia) and activities of daily living (Interview of Deterioration in Daily Living Activities in Dementia). RESULTS: We found no floor effects (
Published: 2012

30. A multicentre RCT on community occupational therapy in Alzheimer's disease: 10 sessions are not better than one consultation

Author: Voigt-Radloff, S., Graff, M.J.L., Leonhart, R., Schornstein, K., Jessen, F., Bohlken, J., Metz, B., Fellgiebel, A., Dodel, R., Eschweiler, G.W., Vernooij-Dassen, M.J.F.J., Olde Rikkert, M.G., and Hull, M.
Subjects: Quality of nursing and allied health care [NCEBP 6], Effective primary care and public health [NCEBP 7], Alzheimer Centre [NCEBP 11], Quality of hospital and integrated care [NCEBP 4], GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract: Contains fulltext : 96580.pdf (Publisher’s version ) (Open Access)
Published: 2011

31. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum

Author: Candelario-Jalil, E., Slawik, H., Ridelis, I., Waschbisch, A., Akundi, R. S., Hull, M., and Fiebich, B. L.
Subjects: endocrine system, FOS: Biological sciences, Quantitative Biology - Tissues and Organs, lipids (amino acids, peptides, and proteins), Tissues and Organs (q-bio.TO)
Abstract: Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effects by activating four specific E-type prostanoid receptors (EP1, EP2, EP3, and EP4). In the present study, we analyzed the expression of the PGE2 receptor EP1 (mRNA and protein) in different regions of the adult rat brain (hippocampus, hypothalamus, striatum, prefrontal cerebral cortex, parietal cortex, brain stem, and cerebellum) using reverse transcription- polymerase chain reaction, Western blotting, and immunohistochemical methods. On a regional basis, levels of EP1 mRNA were the highest in parietal cortex and cerebellum. At the protein level, we found very strong expression of EP1 in cerebellum, as revealed by Western blotting experiments. Furthermore, the present study provides for the first time evidence that the EP1 receptor is highly expressed in the cerebellum, where the Purkinje cells displayed very high immunolabeling of their perikaryon and dendrites, as observed in the immunohistochemical analysis. Results from the present study indicate that the EP1 prostanoid receptor is expressed in specific neuronal populations, which possibly determine the region-specific response to PGE2.
Published: 2007
Full Text: View/download PDF

32. Effetto della compattazione ossea sulle caratteristiche strutturali di fissazioni tibiali utilizzate nella ricostruzione del legamento crociato anteriore

Author: NICOLA PETRONE, Marchiori, M., Hull, M. L., Howell, S. M., and Grover, D.
Published: 2002

33. Postcoital testing : Criterion for positive test was not given

Author: Hull, M G R and Evers, J L H
Subjects: Letters
Published: 1999

34. Why did an effective Dutch complex psycho-social intervention for people with dementia not work in the German healthcare context? Lessons learnt from a process evaluation alongside a multicentre RCT

Author: Voigt-Radloff, S., Graff, M.J.L., Leonhart, R., Hull, M., Olde Rikkert, M.G.M., and Vernooij-Dassen, M.J.F.J.
Subjects: Effective primary care and public health Aetiology, screening and detection [NCEBP 7], Quality of nursing and allied health care [NCEBP 6], Effective primary care and public health [NCEBP 7], Alzheimer Centre [NCEBP 11], Quality of hospital and integrated care [NCEBP 4]
Abstract: Contains fulltext : 97517.pdf (Publisher’s version ) (Open Access) Background The positive effects of the Dutch Community Occupational Therapy in Dementia programme on patients' daily functioning were not found in a multicentre randomised controlled trial (RCT) in Germany. Objectives To evaluate possible effect modification on the primary outcome within the German RCT with regard to (1) participant characteristics, (2) treatment performance and (3) healthcare service utilisation; and (4) to compare the design and primary outcome between the German and the original Dutch study. Methods (1) The impact of participant baseline data on the primary outcome was analysed in exploratory ANCOVA and regression analyses. (2) Therapists completed questionnaires on context and performance problems. The main problems were identified by a qualitative content analysis and focus-group discussion. Associations of the primary outcome with scores of participant adherence and treatment performance were evaluated by regression analysis. (3) Utilisation rates of healthcare services were controlled for significant group differences. (4) Differences in the Dutch and German study design were identified, and the primary outcome was contrasted at the item level. Results (1) Participant characteristics could not explain more than 5% of outcome variance. (2) The treatment performance of some active intervention components was poor but not significantly associated with the primary outcome. (3) There were no significant group differences in the utilisation of healthcare resources. (4) In contrast to the Dutch waiting-control group, the active intervention in the German control group may have reduced group differences in the current RCT. The German patients demonstrated a higher independence at baseline and less improvement in instrumental activities of daily living. Conclusion The differences in outcome may be explained by a more active control treatment, partially poor experimental treatment and less room for improvement in the German sample. Future cross-national transfers should be prepared by pilot studies assessing the applicability of the intervention and patient needs specific to the target country. Trial registration International Clinical Trials Registry Platform, DRKS00000053.
Published: 2011

35. Percutaneous endoscopic gastrostomy feeding

Author: Murray, F. E., Hull, M. A., Rawlings, J., Hawkey, C. J., and Allison, S. P.
Subjects: Letter
Published: 1992

36. Routine testing for HIV infection at fertility clinics

Author: Cahill, D J, Wardle, P G, Hull, M G, and Sullivan, E E
Subjects: Letter
Published: 1991

37. The transfer of human IgG subclasses from mother to foetus

Author: Hay, F. C., Hull, M. G. R., and Torrigiani, G.
Subjects: Immunodiffusion, Infant, Newborn, Articles, Antibodies, Anti-Idiotypic, Umbilical Cord, Blood, Fetus, Pregnancy, Immunoglobulin G, parasitic diseases, Animals, Humans, Female, Rabbits, Maternal-Fetal Exchange
Abstract: The concentration of IgG subclasses was measured in matched pairs of maternal and cord serum by single radial immunodiffusion. IgG1, IgG3 and IgG4 were present in similar amounts in both the mothers and infants. IgG2 was present in the mothers at about 3 times the amount in the cord blood.
Published: 1971

38. Puerto Ricans in a small U.S. city

Author: Klerman, L. V., Jones, J. G., and Hull, M. C.
Subjects: Transients and Migrants, Social Work, Massachusetts, Humans, Community Health Services, Public Health, Research Article
Published: 1966

39. The CIHR Canadian HIV Trials Network co-infection and concurrent diseases core: Canadian guidelines for management and treatment of HIV and hepatitis C co-infection in adults,Le domaine des co-infections et des maladies concomitantes du Réseau canadien pour les essais VIH des IRSC: Lignes directrices canadiennes pour la prise en charge et le traitement de la co-infection par le VIH et l'hépatite C chez les adultes

Author: Hull, M., Giguère, P., Marina Klein, Shafran, S., Tseng, A., Côté, P., Poliquin, M., and Cooper, C.

40. Uptake and biotransformation of gold nanoparticles by a freshwater bivalve

Author: Hull, M. S., Chaurand, P., Jerome ROSE, Jones, J., Gloe, K., and Vikesland, P. J.

41. Novel geotextile mat tailored to reduce odor emission (H2S) from landfills

Author: Rodriguez, R., Liu, R., Hull, M., David Mazyck, and Townsend, T. G.

42. What is the accuracy of transvaginal ultrasound for endometriosis mapping prior to surgery when performed by a sonographer within an outpatient women's imaging centre?

Author: Alison Deslandes, Nayana Parange, Jessie T Childs, Brooke Osborne, M. Louise Hull, Catrina Panuccio, Anthea Croft, Eva Bezak, Deslandes, Alison, Parange, Nayana, Childs, Jessie T, Osborne, Brooke, Hull, M Louise, Panuccio, Catrina, Croft, Anthea, and Bezak, Eva
Subjects: endometriosis, transvaginal ultrasound, Oncology, gynaecology, Radiology, Nuclear Medicine and imaging, sonographer
Abstract: Introduction This study aimed to assess the accuracy of transvaginal ultrasound (TVUS) for the mapping of endometriosis before surgery when performed by sonographers in an outpatient women's imaging centre. Methods A prospective longitudinal cohort study was performed. The study group comprised of 201 women who underwent a comprehensive TVUS assessment, performed by a sonographer. Laparoscopy was performed as the reference standard. Complete TVUS and surgical data were available for 53 women who were included in the final analysis. Results Endometriosis was confirmed at a surgery in 50/53 (94.3%) participants, with 25/53 (47.2%) having deep endometriosis (DE) nodules and/or endometriomas present. TVUS for mapping of DE had an overall sensitivity of 84.0%, specificity of 89.3%, PPV of 87.5%, NPV of 86.2%, LR+ of 7.85, LR- of 0.18, and accuracy of 86.8% (P < 0.001). Ovarian immobility had poor sensitivity for detecting localised superficial endometriosis, DE, adhesions, and/or endometriomas (Left = 61.9% and right = 13.3%) but high specificities (left = 87.5% and right = 94.7%). Site-specific tenderness had low sensitivities and moderate specificities for the same. All soft markers of endometriosis failed to reach statistical significance except for left ovarian immobility (P =
Published: 2022

43. Macrophages infiltrating endometriosis-like lesions exhibit progressive phenotype changes in a heterologous mouse model

Author: Wendy V. Ingman, Mohammad Zahied Johan, M. Louise Hull, Sarah A. Robertson, Johan, Mohammad Zahied, Ingman, Wendy V, Robertson, Sarah A, and Hull, M Louise
Subjects: Adult, endometriosis, 0301 basic medicine, Pathology, medicine.medical_specialty, Biopsy, Immunology, Endometriosis, Nitric Oxide Synthase Type II, Inflammation, macrophage, Lesion, Endometrium, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Peritoneum, medicine, Animals, Humans, Immunology and Allergy, Macrophage, Scavenger receptor, Transplantation Chimera, MHC class II, 030219 obstetrics & reproductive medicine, biology, Macrophages, Histocompatibility Antigens Class II, Scavenger Receptors, Class A, Obstetrics and Gynecology, Phenotype, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Reproductive Medicine, MacGreen mouse, biology.protein, Female, tissue remodelling, medicine.symptom, macrophage polarisation
Abstract: Endometriotic lesion development involves complex interactions between endometrial tissue, the peritoneum and immune cells. Macrophages are essential in this process; however their precise roles are not defined. To investigate whether infiltrating macrophages acquire functionally different phenotypes during lesion development, human endometrial tissues were grafted into immunodeficient mice expressing macrophage-specific green fluorescent protein (GFP). Although the numbers of GFP-positive macrophages were similar in lesions 4, 7, 10 and 14 days after grafting, their surface markers changed over time. Inflammatory markers MHC class II (MHC II) and iNOS were present on 36% and 41% of macrophages respectively early in lesion development at day 4, whereas abundance of tissue remodelling markers peaked later, with arginase 1 most highly expressed on 57% of macrophages at day 7 and scavenger receptor A (CD204) on 66% of macrophages at day 14. This is consistent with a transition from classical M1 macrophage activity to an alternate M2 profile, which correlates to histological hallmarks of initially acute inflammation followed by tissue remodelling during lesion development. This progressive shift in phenotype is likely to be relevant to the mechanisms by which macrophages are central players in endometriosis-like lesion development. Refereed/Peer-reviewed
Published: 2019

44. Effect of Intralipid infusion on peripheral blood T cells and plasma cytokines in women undergoing assisted reproduction treatment

Author: Kerrie L Foyle, Cassandra J Roccisano, Ella S. Green, Kelton Tremellen, David J. Sharkey, Jasmine J. Wilson, Sarah A. Robertson, M. Louise Hull, Lachlan M. Moldenhauer, Foyle, Kerrie L, Sharkey, David J, Moldenhauer, Lachlan M, Green, Ella S, Wilson, Jasmine J., Roccisano, Cassandra J, Hull, M. Louise, Tremellen, Kelton P, and Robertson, Sarah A
Subjects: medicine.medical_treatment, Immunology, T cells, CCL3, Pharmacology, CCL2, Flow cytometry, RAR-related orphan receptor gamma, Immunology and Allergy, Medicine, embryo implantation, Interleukin 8, General Nursing, medicine.diagnostic_test, uterus, business.industry, RC581-607, cytokines, Cytokine, Original Article, Tumor necrosis factor alpha, Immunologic diseases. Allergy, business, infertility, CD8, lipid emulsion
Abstract: Objectives Intravenous infusion of Intralipid is an adjunct therapy in assisted reproduction treatment (ART) when immune‐associated infertility is suspected. Here, we evaluated the effect of Intralipid infusion on regulatory T cells (Treg cells), effector T cells and plasma cytokines in peripheral blood of women undertaking IVF. Methods This prospective, observational pilot study assessed Intralipid infusion in 14 women exhibiting recurrent implantation failure, a clinical sign of immune‐associated infertility. Peripheral blood was collected immediately prior to and 7 days after intravenous administration of Intralipid. Plasma cytokines were measured by Luminex, and T‐cell subsets were analysed by flow cytometry. Results A small increase in conventional CD8+ T cells occurred after Intralipid infusion, but no change was seen in CD4+ Treg cells, or naïve, memory or effector memory T cells. Proliferation marker Ki67, transcription factors Tbet and RORγt, and markers of suppressive capacity CTLA4 and HLA‐DR were unchanged. Dimensionality‐reduction analysis using the tSNE algorithm confirmed no phenotype shift within Treg cells or other T cells. Intralipid infusion increased plasma CCL2, CCL3, CXCL8, GM‐CSF, G‐CSF, IL‐6, IL‐21, TNF and VEGF. Conclusion Intralipid infusion elicited elevated pro‐inflammatory cytokines, and a minor increase in CD8+ T cells, but no change in pro‐tolerogenic Treg cells. Notwithstanding the limitation of no placebo control, the results do not support Intralipid as a candidate intervention to attenuate the Treg cell response in women undergoing ART. Future placebo‐controlled studies are needed to confirm the potential efficacy and clinical significance of Intralipid in attenuating cytokine induction and circulating CD8+ T cells., The lipid emulsion Intralipid is commonly used as an adjunct therapy in assisted reproduction, but whether and how it improves immune adaptation for pregnancy is unknown. Here, we showed Intralipid infusion is associated with elevated plasma levels of several embryotrophic cytokines that may promote implantation, but no change in the abundance or phenotypes of regulatory T cells that mediate maternal immune tolerance.
Published: 2021

45. The comorbidities of dysmenorrhea: a clinical survey comparing symptom profile in women with and without endometriosis

Author: Paul Rolan, M. Louise Hull, Adrian Esterman, Susan E. Evans, Tiffany Brooks, Evans, Susan F, Brooks, Tiffany A, Esterman, Adrian J, Hull, M. Louise, and Rolan, Paul E
Subjects: endometriosis, medicine.medical_specialty, Central sensitization, Endometriosis, dysmenorrhea, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Journal of Pain Research, Pelvis, Stabbing Pain, Pain symptoms, Original Research, stabbing pain, 030219 obstetrics & reproductive medicine, business.industry, Pelvic pain, Chronic pain, pelvic pain, medicine.disease, women's health, Anesthesiology and Pain Medicine, medicine.anatomical_structure, levonorgestrel-releasing intra-uterine device, Migraine, bladder pain syndrome, medicine.symptom, business, chronic pain, headache, 030217 neurology & neurosurgery
Abstract: Susan F Evans,1 Tiffany A Brooks,2 Adrian J Esterman,3,4 M Louise Hull,5 Paul E Rolan6 1School of Medicine, University of Adelaide, Adelaide, SA, Australia; 2School of Psychology, University of South Australia, Adelaide, SA, Australia; 3School of Nursing and Midwifery, University of South Australia, Adelaide, SA, Australia; 4James Cook University, Cairns, QLS, Australia; 5Robinson Research Institute, School of Pediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia; 6School of Medicine, University of Adelaide, Adelaide, SA, Australia Purpose: Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. The frequency of 14 associated symptoms both within and outside the pelvis was determined. Patients and methods: Symptom questionnaires were completed by 168 women with dysmenorrhea, allocated to three groups based on their diagnostic status for endometriosis confirmed (Endo+), endometriosis excluded (Endo−), or endometriosis diagnosis unknown (No Lap). Those with endometriosis confirmed were further divided into current users (Endo+ Hx+) and non-users of hormonal treatments (Endo+ Hx–). Users of hormonal treatments were further divided into users (Endo+ Hx+ LIUCD+) and non-users (Endo+ Hx+ LIUCD–) of a levonorgestrel-releasing intra-uterine contraceptive device (LIUCD). The frequency and number of symptoms within groups and the effect of previous distressing sexual events were sought. Results: Women with and without endometriosis lesions had similar symptom profiles, with a mean of 8.5 symptoms per woman. Only 0.6% of women reported dysmenorrhea alone. The presence of stabbing pelvic pains was associated with more severe dysmenorrhea (P=0.006), more days per month of dysmenorrhea (P=0.003), more days per month of pelvic pain (P=0.016), and a diagnosis of migraine (P=0.054). The symptom profiles of the Endo+ Hx+ and Endo+ Hx– groups were similar. A history of distressing sexual events was associated with an increased number of pain symptoms (P=0.003). Conclusion: Additional symptoms are common in women with dysmenorrhea, and do not correlate with the presence or absence of endometriosis lesions. Our study supports the role of central sensitization in the pain of dysmenorrhea. The presence of stabbing pelvic pains was associated with increased severity of dysmenorrhea, days per month of dysmenorrhea, days per month of pelvic pain, and a diagnosis of migraine headache. A past history of distressing sexual events is associated with an increased number of pain symptoms. Keywords: dysmenorrhea, endometriosis, headache, bladder pain syndrome, chronic pain, pelvic pain, levonorgestrel-releasing intra-uterine device, stabbing pain
Published: 2018

46. Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis

Author: Wendy V. Ingman, Sarah A. Robertson, M. Zahied Johan, Wendy L. Hodge, M. Louise Hull, Hull, M Louise, Johan, M Zahied, Hodge, Wendy L, Robertson, Sarah A, and Ingman, Wendy V
Subjects: endometriosis, Adult, Pathology, medicine.medical_specialty, Stromal cell, medicine.medical_treatment, Ovariectomy, Transplantation, Heterologous, Endometriosis, transforming growth factor beta1, macrophage, Mice, SCID, Biology, heterologous, Pathology and Forensic Medicine, Lesion, Transforming Growth Factor beta1, Mice, Young Adult, medicine, Animals, Humans, Myofibroblasts, Cell Proliferation, Severe combined immunodeficiency, Macrophages, immune deficiency, Middle Aged, medicine.disease, Mice, Mutant Strains, Transplantation, cell proliferation, Cytokine, medicine.anatomical_structure, Female, medicine.symptom, Myofibroblast, transplantation, Blood vessel
Abstract: Transforming growth factor-β1 (TGFB1) is a multifunctional cytokine that is abundant in both endometriotic lesions and the peritoneal fluid in women with endometriosis. However, the role of TGFB1 in the development of endometriosis is as yet undefined. In the present study, we investigated the physiologic function of TGFB1 in endometriotic lesion development, using Tgfb1-null mutant mice on a background of severe combined immunodeficiency. Xenotransplantation of human eutopic endometrial tissue resulted in development of endometriosis-like lesions in 63% of ovariectomized estrogen-supplemented Tgfb1-null mutant mice and in 68% of wild-type control mice. Median lesion weight was reduced by 11-fold in Tgfb1-null mice compared with wild-type control mice, and the fraction of glandular epithelium in lesions from Tgfb1-null mice was reduced by 32% compared with that in control mice. In lesions from Tgfb1-null mice, the relative abundance of both macrophages and α-smooth muscle actinpositive myofibroblasts was reduced by 66% and 47%, respectively. Deficiency of TGFB1 neither altered the percentage of proliferating cells in the epithelial or stromal compartments of the lesions nor affected blood vessel density or vessel size. Observation of this study indicates that host-derived TGFB1 deficiency suppresses endometriotic lesion development and provides proof of principle that targeting TGFB1 signaling pathways in cells that support the survival of ectopic endometrium may be an effective therapeutic approach in women with endometriosis. Refereed/Peer-reviewed
Published: 2011

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

46 results on '"Hull M"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources