17 results on '"Hui-Zhong Xu"'
Search Results
2. Data from Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing
- Author
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Dong-Er Zhang, Xiang-Dong Fu, Hu Cang, Jeremy N. Rich, Klaus-Peter Knobeloch, Balázs Győrffy, Yu Zhou, Ming Yan, Kei-ichiro Arimoto, Hua Cheng, Christoph Burkart, Leo J.Y. Kim, Dan Liu, Hui-Zhong Xu, Sayuri Miyauchi, and Jun-Bao Fan
- Abstract
Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the ISG UBA7 is a tumor suppressor in breast cancer. UBA7 encodes an enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of another ISG (ISG15) to cellular proteins in a process known as “ISGylation.” ISGylation of other ISGs, including STAT1 and STAT2, synergistically facilitates production of chemokine-receptor ligands to attract cytotoxic T cells. These gene-activation events are further linked to clustering and nuclear relocalization of STAT1/2 within IFN-induced promyelocytic leukemia (PML) bodies. Importantly, this coordinated ISG–ISGylation network plays a central role in suppressing murine breast cancer growth and metastasis, which parallels improved survival in patients with breast cancer. These findings reveal a cooperative IFN-inducible gene network in orchestrating a tumor-suppressive microenvironment.Significance:We report a highly cooperative ISG network, in which UBA7-mediated ISGylation facilitates clustering of transcription factors and activates an antitumor gene-expression program. These findings provide mechanistic insights into immune evasion in breast cancer associated with UBA7 loss, emphasizing the importance of a functional ISG–ISGylation network in tumor suppression.This article is highlighted in the In This Issue feature, p. 327
- Published
- 2023
3. Supplementary Tables from Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing
- Author
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Dong-Er Zhang, Xiang-Dong Fu, Hu Cang, Jeremy N. Rich, Klaus-Peter Knobeloch, Balázs Győrffy, Yu Zhou, Ming Yan, Kei-ichiro Arimoto, Hua Cheng, Christoph Burkart, Leo J.Y. Kim, Dan Liu, Hui-Zhong Xu, Sayuri Miyauchi, and Jun-Bao Fan
- Abstract
Supplementary tables
- Published
- 2023
4. Insufficiency of Mrpl40 disrupts testicular structure and semen parameters in a murine model
- Author
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Hai-Tao Lv, Wen-Hong Lu, Ying Liu, Long-Long Fu, Hui-Zhong Xu, Yi-Ming Zheng, Wei-Xi Li, and Guang-Hui Qian
- Subjects
Urology ,General Medicine - Published
- 2023
5. Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing
- Author
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Kei-ichiro Arimoto, Leo J.Y. Kim, Balázs Győrffy, Klaus-Peter Knobeloch, Dong-Er Zhang, Hua Cheng, Christoph Burkart, Xiang-Dong Fu, Jeremy N. Rich, Hu Cang, Jun-Bao Fan, Yu Zhou, Hui-Zhong Xu, Ming Yan, Sayuri Miyauchi, and Dan Liu
- Subjects
T-Lymphocytes ,Gene regulatory network ,Breast Neoplasms ,Ubiquitin-Activating Enzymes ,medicine.disease_cause ,Article ,Metastasis ,Mice ,Interferon ,medicine ,Animals ,Humans ,Gene Regulatory Networks ,STAT1 ,Ubiquitins ,Transcription factor ,Cell Proliferation ,Regulation of gene expression ,biology ,virus diseases ,STAT2 Transcription Factor ,medicine.disease ,ISG15 ,Gene Expression Regulation, Neoplastic ,STAT1 Transcription Factor ,Oncology ,Interferon Type I ,Cancer research ,biology.protein ,Female ,Carcinogenesis ,Transcription Factors ,medicine.drug - Abstract
Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the ISG UBA7 is a tumor suppressor in breast cancer. UBA7 encodes an enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of another ISG (ISG15) to cellular proteins in a process known as “ISGylation.” ISGylation of other ISGs, including STAT1 and STAT2, synergistically facilitates production of chemokine-receptor ligands to attract cytotoxic T cells. These gene-activation events are further linked to clustering and nuclear relocalization of STAT1/2 within IFN-induced promyelocytic leukemia (PML) bodies. Importantly, this coordinated ISG–ISGylation network plays a central role in suppressing murine breast cancer growth and metastasis, which parallels improved survival in patients with breast cancer. These findings reveal a cooperative IFN-inducible gene network in orchestrating a tumor-suppressive microenvironment. Significance: We report a highly cooperative ISG network, in which UBA7-mediated ISGylation facilitates clustering of transcription factors and activates an antitumor gene-expression program. These findings provide mechanistic insights into immune evasion in breast cancer associated with UBA7 loss, emphasizing the importance of a functional ISG–ISGylation network in tumor suppression. This article is highlighted in the In This Issue feature, p. 327
- Published
- 2020
6. Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy
- Author
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Li-Fan Lu, Alexandra Bortnick, Hui-Zhong Xu, Sha Sun, Sylvia M. Evans, Paolo Beuzer, Zhenmin Hong, Hu Cang, Kevin D. Corbett, Cornelis Murre, Tengqian Sun, Sunglim Cho, Joshua Axelrod, Lunfeng Zhang, Qiongzheng Hu, Qing Ye, Zhisong Tong, and Melissa Wang
- Subjects
Male ,Cell Cycle Proteins ,HORMA domain ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Meiosis ,Spermatocytes ,Homologous chromosome ,Animals ,030304 developmental biology ,Physics ,Mammals ,0303 health sciences ,Microscopy ,Multidisciplinary ,Cohesin ,Staining and Labeling ,Super-resolution microscopy ,Synaptonemal Complex ,C-terminus ,Chromosome ,Biological Sciences ,Chromosomes, Mammalian ,Cell biology ,DNA-Binding Proteins ,Synaptonemal complex ,030217 neurology & neurosurgery - Abstract
During prophase I of meiosis, chromosomes become organized as loop arrays around the proteinaceous chromosome axis. As homologous chromosomes physically pair and recombine, the chromosome axis is integrated into the tripartite synaptonemal complex (SC) as this structure’s lateral elements (LEs). While the components of the mammalian chromosome axis/LE—including meiosis-specific cohesin complexes, the axial element proteins SYCP3 and SYCP2, and the HORMA domain proteins HORMAD1 and HORMAD2—are known, the molecular organization of these components within the axis is poorly understood. Here, using expansion microscopy coupled with 2-color stochastic optical reconstruction microscopy (STORM) imaging (ExSTORM), we address these issues in mouse spermatocytes at a resolution of 10 to 20 nm. Our data show that SYCP3 and the SYCP2 C terminus, which are known to form filaments in vitro, form a compact core around which cohesin complexes, HORMADs, and the N terminus of SYCP2 are arrayed. Overall, our study provides a detailed structural view of the meiotic chromosome axis, a key organizational and regulatory component of meiotic chromosomes.
- Published
- 2019
7. Study on the Utilization of FBC Ashes as Cement Admixture
- Author
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Li Hua Zhang, Yu Long Ma, Jing Xiang Liu, Hui Zhong Xu, Yuan Ming Song, and Yu Bo Yue
- Subjects
Cement ,Materials science ,Compressive strength ,Flexural strength ,Waste management ,Pulverized coal-fired boiler ,Metallurgy ,General Medicine ,Fluidized bed combustion ,Mortar ,Combustion ,Cement mortar - Abstract
Compared with ordinary Pulverized Coal Combustion (PC) fly ashes, Fluidized Bed Combustion (FBC) ashes have some special properties. The effect of FBC ashes content on the strength of cement mortar was studied, and the physical properties of FBC ashes-cement mortar with 30% FBC ashes were also investigated. The results show that the flexural and compressive strength at 7 and 28 days of the mortar gradually decreases with the increase of FBC ashes content. Under the same dosage, the strength of FBC ashes-cement mortar is greater than that of PC fly ashes-cement mortar. The FBC ashes-cement system presents a normal setting time but poor soundness with more than 3.5% SO3. This work confirms that the properties of FBC ashes-cement system are superior to those of PC fly ashes-cement system when SO3 content is no more than 3.5%.
- Published
- 2011
8. Inhibition of the Expansion of CFBC Ash
- Author
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Bo Wang, Zhi Juan Wang, Hui Zhong Xu, and Yuan Ming Song
- Subjects
Compressive strength ,Materials science ,General Engineering ,Mortar ,Composite material ,Curing (chemistry) ,Thermal expansion - Abstract
The destructive expansion of CFBC ash is the bottleneck problem for its utilization in building materials. The addition of chemical substances and autoclave curing were used to inhibit the expansion in the paper. The results show that the addition of 1% CaCl2 or 1% Na2CO3 can decrease the 28 d linear expansion ratio of CFBC ash-water mortars by about 19%, with no disadvantage influence on the compressive strength. Moreover, the linear expansion ratio of CFBC ash-clinker-water pastes was below 5×10-4 after autoclave curing. The work confirms that the expansion of CFBC ash can be inhibited effectively by the way of autoclave curing.
- Published
- 2011
9. The Effect of Anhydrite on the Hydration of CFBC Ash-Clinker-Water System
- Author
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Yuan Ming Song, Bo Wang, and Hui Zhong Xu
- Subjects
Ettringite ,chemistry.chemical_compound ,Anhydrite ,chemistry ,Clinker (waste) ,Metallurgy ,General Engineering ,Mineralogy ,Water content - Abstract
The effect of anhydrite on the hydration of CFBC ash-clinker-water system was investigated by ettringite content, chemically combined water content and X-ray diffraction. The results show that the effect of anhydrite on ettringite content at earlier age is significantly greater than that at later age. This work confirms that anhydrite plays a significant role in promoting the hydration of CFBC ash-clinker-water system.
- Published
- 2011
10. Effects and Mechanism of Titanium Modification on Shrinkage Cavity and Porosity of Cast Steel
- Author
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Hui Zhong Xu, Hua Shun Yu, and Hai Tao Wang
- Subjects
Viscosity ,Materials science ,chemistry ,Scanning electron microscope ,Metallurgy ,chemistry.chemical_element ,Induction furnace ,General Medicine ,Nitride ,Porosity ,Supercooling ,Shrinkage ,Titanium - Abstract
The effects of titanium modification, which was added along with the pouring liquid in ladles, on the shrinkage porosity and cavity of cast steel ZG35 smelted in intermediate frequency induction furnace were studied. Proper content of titanium could effectively increase the volume of concentrated shrinkage cavity, and restrain the forming of shrinkage porosity. The concentrated shrinkage cavity was analyzed quantitatively by stuffing wet gluten and draining water method. The maximal cavity arrived at 0.15wt.% titanium modification. By scanning electron microscope (SEM) and energy disperse spectroscope (EDS) analysis, it was found that TiC, acting as heterogeneous nuclei, could refine the structure grains, diminish the strong dendrites, and increase the fluidity and feeding capacity of steel liquid. However, overdoes titanium modification easily caused mass nitrides or oxides, which kept solid phases with high meting point in metal liquid to increase its viscosity and decrease the fluidity. On the other hand, these solid state titanium compounds enlarged the composition supercooling, so the metal liquid changed from sequential solidification to simultaneous solidification, resulting in inadequate metal liquid feeding, less oncentrated shrinkage cavity and serious shrinkage porosity.
- Published
- 2010
11. Effects and Mechanism of Titanium on Cast Fluidity of ZG45
- Author
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Hai Tao Wang, Hui Zhong Xu, and Hua Shun Yu
- Subjects
Materials science ,Scanning electron microscope ,Metallurgy ,General Engineering ,Oxide ,chemistry.chemical_element ,Induction furnace ,chemistry.chemical_compound ,Dendrite (crystal) ,chemistry ,Casting (metalworking) ,Composite material ,Supercooling ,Shrinkage ,Titanium - Abstract
The effects of titanium modification, which was added along with the pouring liquid in ladles, on the shrinkage porosity and cavity of cast steel ZG45 smelted in intermediate frequency induction furnace were studied. The metal liquid fluidity was measured by casting spiral samples. 0.2 wt.% titanium modification achieved the highest fluidity for steel liquid. Proper content of titanium could effectively increase the volume of concentrated shrinkage cavity, and restrain the forming of shrinkage porosity. By scanning electron microscope (SEM) and energy disperse spectroscope (EDS) analysis, it was found that TiC, acting as heterogeneous nuclei, could refine the structure grains, diminish the strong dendrite, and increase the fluidity and feeding capacity of steel liquid. However, overdoes titanium modification easily caused mass oxide TiO2, which kept solid phases with high meting point in metal liquid to increase its viscosity and decrease the fluidity. Meanwhile, these solid state titanium compounds enlarged the composition supercooling, so the metal liquid changed from sequential solidification to simultaneous solidification, resulting in inadequate metal liquid feeding, less oncentrated shrinkage cavity and serious shrinkage porosity.
- Published
- 2010
12. Exploring characteristics of bioelectricity generation and dye decolorization of mixed and pure bacterial cultures from wine-bearing wastewater treatment
- Author
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Wen-Ming Chen, Jing-Long Han, Ying Liu, Bor-Yann Chen, Hui-Zhong Xu, and Chang-Tang Chang
- Subjects
Environmental Engineering ,Microbial fuel cell ,Bioelectric Energy Sources ,Wine ,Bioengineering ,Acinetobacter junii ,Microbiology ,Water Purification ,Pseudomonas ,RNA, Ribosomal, 16S ,Electrochemistry ,Environmental Chemistry ,Food science ,Coloring Agents ,Phylogeny ,Pseudomonas plecoglossicida ,Acinetobacter ,Sewage ,biology ,Biofilm ,Pseudomonas koreensis ,biology.organism_classification ,Pollution ,Stenotrophomonas ,Activated sludge ,Aeromonas ,Gammaproteobacteria - Abstract
This study uncovered microbial characteristics of bioelectricity generation and dye decolorization in single-chamber microbial fuel cells (MFCs) using activated sludge for wine-containing wastewater treatment. Phylogenetic tree analysis on 16S rRNA gene fragments indicated that the predominant strains on anodic biofilm in acclimatized MFCs were Gamma-Proteobacteria Aeromonas punctata NIU-P9, Pseudomonas plecoglossicida NIU-Y3, Pseudomonas koreensis NIU-X8, Acinetobacter junii NIU-Y8, Stenotrophomonas maltophila NIU-X2. Our findings showed that the current production capabilities of these pure strains were only ca. 10% of those of their mother activated sludge, indicating that synergistic interactions among microbes might be the most influential factor to maximize power generation in MFCs. Plus, these electrochemically active strains also performed reductive decolorization of C.I. reactive blue 160, suggesting that bioelectricity generation might be directly associated to azo dye decolorization to deal with electron transfer on anodic biofilm in MFCs.
- Published
- 2010
13. Exploring power generation of single-chamber microbial fuel cell using mixed and pure cultures
- Author
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Chin-Tsan Wang, Hui-Zhong Xu, Chang-Tang Chang, Jing-Long Han, Yuh-Chung Hu, Wen-Ming Chen, Ying Liu, and Bor-Yann Chen
- Subjects
Microbial fuel cell ,Strain (chemistry) ,biology ,business.industry ,General Chemical Engineering ,Aeromonas punctata ,General Chemistry ,biology.organism_classification ,Biotechnology ,Electricity generation ,Degradation (geology) ,Food science ,business ,Faraday efficiency ,Single chamber ,Power density - Abstract
This study tended to explore factors (e.g., initial substrate concentration, microbial species) affecting electricity generation of air-cathode single-chamber microbial fuel cell (MFC) under fed-batch mode of operation. The maximum coulombic efficiency (CE) and power density taking place at initial concentration of 300 mg COD/L were 8.16% and 68.5 mW/m2, respectively. Rich media would stably provide power output in MFC for long periods of time. As part of COD removal was used for aerobic degradation rather than bioelectricity generation, lower CE values (max. 8.16%) in MFCs were revealed. According to profiles of protein expression and PCR-augmented 16S rRNA analyses for strain identification, >99.5% of nucleotide sequence of predominant pure strains in MFC was identical to type strain Aeromonas punctata.
- Published
- 2010
14. Minimal switching voltage for magnetization reversals in asymmetric nanorings
- Author
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Xiao Chen, Jing Hua, Jun-Ming Liu, and Hui-Zhong Xu
- Subjects
Physics ,Condensed matter physics ,Field (physics) ,media_common.quotation_subject ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Condensed Matter Physics ,Asymmetry ,Electronic, Optical and Magnetic Materials ,Tunnel magnetoresistance ,Magnetization ,Commutation ,Micromagnetics ,Nanoring ,Voltage ,media_common - Abstract
Micromagnetic simulations based on the Landau-Lifshitz-Gilbert equation are presented to study spin-polarized current induced magnetization switching in a symmetric nanoring-shaped magnetic tunnel junctions. The results show that in an a noring with an intermediate eccentric distance S, the critical switching voltage V(C) reaches the minimum whose magnitude is less than half of the voltage for a symmetric nanoring. In addition to the spin-transfer torque, the current induced Ampere ere. field is found to play a crucial part in the switching process. Analysis is given to explain the existence of such an energy valley that leads to the minimal voltage. (C) 2009 Elsevier B.V. All rights reserved.
- Published
- 2009
15. Assessment upon azo dye decolorization and bioelectricity generation by Proteus hauseri
- Author
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Chung-Chuan Hsueh, Bor-Yann Chen, Chang-Tang Chang, Chyow-San Chiou, Yongtao Ding, Kae-Long Lin, Meng-Meng Zhang, and Hui-Zhong Xu
- Subjects
medicine.medical_specialty ,Environmental Engineering ,Microbial fuel cell ,Bioelectric Energy Sources ,Color ,Bioengineering ,Photochemistry ,chemistry.chemical_compound ,Electricity ,medicine ,Coloring Agents ,Waste Management and Disposal ,Waste management ,Renewable Energy, Sustainability and the Environment ,General Medicine ,Biodegradation ,Proteus ,Proteus hauseri ,Biodegradation, Environmental ,Wastewater ,chemistry ,Bioelectrochemistry ,Diazo ,Energy source ,Azo Compounds ,Single chamber - Abstract
This study explored dye decolorization and bioelectricity generation of indigenous Proteus hauseri ZMd44 for dye-bearing wastewater treatment. Chemical structures of azo dyes apparently affected the performance of dye biodecolorization. Additions of diazo dye C.I. reactive blue 160 (RBu160) stimulated simultaneous dye decolorization and bioelectricity generation of ZMd44 in single chamber microbial fuel cells (MFCs). However, high-level additions of RBu160 repressed capabilities of power production in MFC due to competition of electrons used for reductive decolorization. Decolorized intermediates of RBu160-phenyl methadiamine and 5-sulfoanthranilic acid as electron shuttles might mediate electron transport for current generation in MFC.
- Published
- 2009
16. Comparative study on characteristics of azo dye decolorization by indigenous decolorizers
- Author
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Yongtao Ding, Chung-Chuan Hsueh, Kae-Long Lin, Hui-Zhong Xu, Wen-Ming Chen, Meng-Meng Zhang, Bor-Yann Chen, and Chang-Tang Chang
- Subjects
Environmental Engineering ,Klebsiella pneumoniae ,Molecular Sequence Data ,Taiwan ,Color ,Bioengineering ,Centrifugation ,Biology ,Waste Disposal, Fluid ,Microbiology ,Water Purification ,Bioreactors ,RNA, Ribosomal, 16S ,Cluster Analysis ,Coloring Agents ,Waste Management and Disposal ,Phylogeny ,Soil Microbiology ,Strain (chemistry) ,Bacteria ,Base Sequence ,Renewable Energy, Sustainability and the Environment ,General Medicine ,Enterobacter ,Sequence Analysis, DNA ,Ribosomal RNA ,biology.organism_classification ,16S ribosomal RNA ,Fungicide ,Aeromonas hydrophila ,Biodegradation, Environmental ,Spectrophotometry, Ultraviolet ,Water Microbiology ,Azo Compounds - Abstract
This study provides a first attempt to explore indigenous strains with excellent decolorization capability from the most biodiverse region in Taiwan for dye-bearing wastewater treatment. Bacterial isolates were obtained via serial selections under selection pressure of the fungicide nystatin and model textile dye(s). According to profiles of protein expression and PCR-augmented 16S rRNA gene analyses for strain identification, >99% of nucleotide sequences in isolated strains were identical to type strains Aeromonas hydrophila, Klebsiella pneumoniae, Enterobacter cancerogenus, Proteus hauseri, Acinetobacter johnsonii. This first-attempt study not only explored most abundant decolorizers in Taiwan, but also compared their color removal performance for further applications.
- Published
- 2009
17. Design and fabrication of self-biased millimeter wave circulator using barium ferrite thin films
- Author
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Bin PENG, Yuan WANG, Hui-Zhong XU, Wen-Xu ZHANG, and Wan-Li ZHANG
- Subjects
Atomic and Molecular Physics, and Optics - Published
- 2013
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