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Abstract: After tooth extraction, the alveolar ridge undergoes resorption and atrophy, which usually leads to a wide range of tissue dimensional changes. Preservation of the alveolar ridge can maintain its volume, reduce ridge resorption, and help subsequent dental implant treatment. This retrospective cohort study aims to investigate the marginal bone stability of implants placed in alveolar ridge preservation areas using deproteinized bovine bone mineral with 10% collagen (DBBM-collagen) combined with a native collagen membrane (CM). In this study, forty-seven implant sites divided into either intact or defective extraction sockets were included, using vertical bite-wing films to measure the bone level at baseline, 6 months, and 12 months after implant prosthesis placement. The result of peri-implant mean bone loss was -0.03 ± 0.84mm at 12 months compared to baseline. There was no significant difference in mesial and distal sites compared to baseline. In addition, no significant difference was found between the defective and intact sockets for marginal bone changes. Therefore, ridge preservation combined with DBBM-collagen and CM can provide an ideal alveolar ridge, simplify dental implant procedures, and maintain implant marginal bone stability. &nbsp

Purpose: The purpose of this study was to analyze the publication trends during the past 25 years (1996-2020) in The Journal of Taiwan Academy of Periodontology (J Taiwan Periodontol). Material and Methods: The search strategy consisted of a manual search of the J Taiwan Periodontol in the library from September 1996 to December 2004, and an electronic search of the Taiwan Academy of Periodontology (TAP) website and Airiti Library for all the publications from March 2005 to December 2020. The bibliometric parameters, including year of publication, study design, scope of study, Taiwanese institute of origin, inter-in- stitute collaboration, authorship, inter-nation collaboration, and funding resource, were analyzed. Multivariable linear regression was used to analyze the publications trends. Sig- nificance was accepted when the P value was < 0.05. Results: The study design of reviews and case report/series consisted of the majority of publications, and the number of publications has been steady throughout the investigat- ed time periods (1996-2000, 2001-2005, 2006-2010, 2011-2015, 2016-2020). However, cross-sectional studies declined significantly throughout the time periods (P &nbsp

Sinningia bullata is a tuberous member of the flowering plant family Gesneriaceae. Prior to this work, the antibacterial, antioxidant, and cytotoxic properties of S. bullata were undetermined. Here, we prepared different extracts from the leaf, stem, and tuber of S. bullata and investigated their pharmacological activities. The leaf extract of S. bullata, obtained by 100% acetone (Sb-L-A), had the highest total flavonoid content, antioxidation capacity, and cytotoxic and antibacterial activities. Sb-L-A displayed a broad range of antibacterial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The inhibition zones of Sb-L-A ranged from 8 to 30 mm and were in the following order: S. aureus > E. coli > P. aeruginosa. Incubation of B16F10 melanoma cells with Sb-L-A at a concentration of 80 μg/mL caused deaths at the rate of 96%, reduced migration by 100%, suppressed proliferation and colony formation by 99%, and induced apoptosis, which was observed in 96% of the B16F10 cells. In addition, the cytotoxic activities of Sb-L-A were synergistically enhanced when coacting with the antitumor drug epothilone B. Sb-L-A was also used to determine the cytotoxic effects against 4T1 mammary carcinoma cells. Sb-L-A of 60 μg/mL boosted the distribution of the G2 phase from 1.4% to 24.4% in the B16F10 cells. Accordingly, Sb-L-A might suppress melanoma cell proliferation by inducing G2 cell-cycle arrest. The most abundant compounds in Sb-L-A were identified using gas chromatography–mass spectrometry. The top two contents in this extract were adlupulone and villosin. Overall, the collective data in this study may indicate the pharmacological potentials of Sb-L-A for possible medical applications.