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Additional file 1: Supplementary Table 1. Dose adjustment criteria. Supplementary Table 2. TRAEs of BPI-9016M occurring in SS. Supplementary Table 3. Major PK parameters of BPI-9016M, M1and M2-2 after treatment with multiple doses of BPI-9016M for 28 days in Cycle 1 based on population PK analysis. Supplementary Table 4. Mean Ctrough of BPI-9016M, M1 and M2-2 after treatment with multiple doses of BPI-9016M at Cycle 1 Day 8, Day 15 and Day 22 based on routine PK analysis.

Osimertinib is a novel, irreversible, mutant‐selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor targeting EGFR mutations and the EGFR T790 mutation. Here, we report a woman with EGFR‐mutated lung adenocarcinoma who, after 23‐month treatment with gefitinib, developed the EGFR T790M mutation, which converted the T790M status from positive to negative before osimertinib treatment and developed MET amplification, leading to rapid progression on osimertinib in two months. Subsequent treatment with crizotinib and c‐Met inhibitor plus gefitinib also failed to improve the clinical outcome, suggesting the potential existence of another resistance mechanism. Our findings revealed the underlying multiple and heterogeneous mechanisms in resistance to osimertinib, suggesting combination strategies should be considered post‐osimertinib progression.

An comparison of technical specification and updated operation results between two USC coal fired boilers namely RDK-8, Germany and WGQ-3, China has been considered under the global scenario related to the variation of industrial production structure, power demand cut down, more stringent carbon dioxide depression and larger quantity of renewable units engaged into the grid, in this respect a discussion and analysis have been carried out subjected to low grade heat recovering and harmful emission prevention from boiler flue gas and introduction carbon harmful emission prevention from boiler flue gas and their multiple benefits on energy saving and environmental protection, moreover the experience and gains in the field of flue gas heat recovering and mitigating pollution, including the proprietary technique (WGGH) by SPERI are briefly stated, thereby a conclusion of enlightenment for further development of these units is mentioned.