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Background: Necrotizing fasciitis is a potentially life-threatening soft tissue infection, characterized by necrosis of the fascia, subcutaneous tissue, adipose tissue and can be fatal. NF is most common in immunocompromised hosts but may also occur in healthy patients without apparent antecedent injury. It is usually caused by either Group A streptococci or a polymicrobial, synergistic infection. The case that we present is unique in the Republic of Armenia, necrotizing fasciitis of the face in a child. Methods: We report the case of 3,5-year-old children who were treated for NF in our unit, inclusive, were reviewed retrospectively. Information recorded included medical history, clinical characteristics, diagnostic procedures, treatment methods, and the outcome. Results: The essence of the treatment was to prevent further development of necrosis, taking the child out of the state of general intoxication, in connection with, early surgical debridement, anti-intoxication, antibacterial therapy were carried out in several stages. In result, auto transplantation by full thickness skin autograft has been done, maintaining the aesthetic appearance of the wound. Conclusion: Because necrotizing fasciitis is a surgical emergency, the patient should be admitted immediately to a surgical intensive care unit, where the surgical staff is skilled in performing extensive debridement and reconstructive surgery. Despite the fact that it is rare in children, according to our data, it turned out that the reason for the penetration of microorganisms may be an incomplete injection. Clinicians should be aware of these infections, as early treatment can increase survival.

The aim of the study is investigation of the level, similarities and differences of coaches and athletes anti-doping knowledge in Armenia, Georgia and Moldova to identify the essential components of an education program for coaches to ensure coaches positive impact on attitudes and beliefs of their athletes towards doping. The results of study allow us to make a conclusion that in addition to requests of WADA Education International Standard, the following aspects will be necessary to include in the Education Program for Coaches in Armenia, Georgia and Moldova: Explanation of the difference between substances prohibited at all times and only in-competition in detail. Included in presentations, explanation of differences between specific and non-specific stimulants and glucocorticoids use is needed. Explanation of Anti-Doping organizations’ roles and responsibilities of testing and sanctions of the athletes of national and international levels. A separate attention to the sanctions of athletes support personnel Explanation of the difference between substances prohibited at all times and only in-competition in detail. Included in presentations, explanation of differences between specific and non-specific stimulants and glucocorticoids use is needed. Explanation of the difference between sport disciplines in the aspect of Anti-Doping Rule Violation (ADVR) statistics. The important point will be the comparison of ADRV statistics in the world and each country.

The paper summarizes the results of our research conducted on the study of corundum crystals with various activating agents for development and creation of UV and VUV detectors. Corundum crystals with certain parameters were chosen as the optimal converter of UV and VUV radiant energy into the visible region of radiation for creating UV and VUV detectors with high spatial and temporal characteristics, which also have high radiation and thermal resistance.

Wine made or stored in clayware ceramic pots attracts the attention of consumers, but this practice is less studied than when classic stainless steel tanks or wood barrels are used. It is known that wine can be influenced by the container in which it is aged. To analyse the influence of ceramics on the chemical composition of wine, Armenian clay-based ceramic tablets were immersed in model wine and aged from 1 hour up to 16 months at 25 °C in darkness. The concentrations of 26 elements (namely: Al, B, Ba, Be, Ca, Cd, Co, Cr, Cu, Fe, Hg, K, Li, Mg, Mn, Mo, Na, Ni, P, Pb, S, Sr, Ti, V, W and Zn) in 19 samples were determined by ICP-AES analysis. Proton time domain NMR relaxometry was used to characterise the iron redox processes that occurred in the model wine in contact with a ceramic. A fast increase in the pH of the model wine in contact with the bare ceramic tablet (from 2.35 to 5) was recorded in 4 days. The coating of the ceramic tablets with beeswax showed a significant effect on the interaction between the model wine and the ceramic.

Oral and maxillofacial orthopedics is engaged in prosthetics of congenital and acquired defects of the maxillofacial region resulting from resections of the jaws of neoplasms and also as a result of injuries. In the presence of defects in the maxillofacial region, various methods of treatment are currently used, including removable prosthetics, reconstruction of the defect with a vascularized musculoskeletal autograft, and prosthetics using implants. This direction tends to be further developed and improved, which will contribute to the full integration of the patient into society. This article presents the procedure for prosthetics of a resection defect of the upper jaw (clinical case) followed by prosthetic rehabilitation.

Today's education faces modern challenges in the context of profound methodological and content changes in the world. Global realities have a fundamental impact on education processes, research and projected outcomes. As a result of the COVID-19 pandemic and thanks to the development of information technologies, the learning process of higher education is currently organized in a hybrid manner, with combination of face-to-face and distance learning modalities. We were somewhat prepared for it, because yet in 2010, the Government of Armenia had adopted a decision to approve the procedure for distance learning of Higher, Postgraduate and Vocational education specialties (Government of the RA – Hayastani Hanrapetutyun karavarutyan voroshumy. 2010). In order to understand the current issues of distance education and aiming to help to improve the process in the context of hybrid education, we conducted research and explored the process of organization of distance learning from different perspectives, tested its effectiveness and identified various problems at Khachatur Abovian Armenian State Pedagogical University?

Medical education is a fundamental link in the formation of qualified medical personnel. At different periods of development of the health care system, the system of education of health workers was also revised and improved. The article describes the stages of formation and development of the system of postgraduate education of medical workers in Armenia. To assess the current situation and the necessity to update the current system of postgraduate medical education, we conducted a survey in which participated the clinical residents, employees, and heads of departments, medical workers, leading specialists and representatives of the Ministry of Health of the Republic of Armenia.

Chemical and bacterial preparations have been tested in order to fight against Robinia pseudoacacia pests Obolodiplosis robiniae and Euura tibialis, some of the most widely spread fragrant tree species in Yerevan gardens. Among the preparations used against E. Tibialis, the highest biological efficiency was registered by the chemical preparation of antion (94,0 %) with a consumption rate of 1.7 l/ha, and Bacillus thuringiensis strain (91,0 %) with a concentration of 3 l/ha among the bacterial preparations. In the case of O. robiniae, high result (94,0 %) was registered by acpeline at the rate of consumption of 1 l/ha, and again the Bt 26-70 (85,4 %) strain at a rate of 3 l/ha among the bacterial preparations. Երևանի այգիներում տարածված բուրումնավետ ծառատեսակներից՝ կեղծ ակացիայի վնասատուներ սպիտակ ակացիայի գալամլակի (Obolodiplosis robiniae) և ակացիայի սղոցողի (Euura tibialis) դեմ պայքարի նպատակով փորձարկվել են քիմիական և բակտերիական պատրաստուկներ: E. tibialis -ի դեմ կիրառվող միջոցներից առավել բարձր կենսաբանական արդյունավետություն գրանցել է 1,7 լ/հա ծախսի նորմայով անթիո (94,0 %) քիմիական պատրաստուկը, իսկ բակտերիական պատրաստուկներից 3լ/հա խտանյութ չափաքանակով Bacillus thuringiensis 26-70-ը (91,0%) շտամը: O. robiniae -ի դեպքում բարձր արդյունք (94,0 %) դրսևորել է ակպելինը՝ 1լ/հա ծախսի նորմայով, իսկ բակտերիական պատրաստուկներից կրկին 3 լ/հա խտանյութ չափաքանակով Bt 26-70-ը (85,4 %) շտամը: Для борьбы вредителей (E. tibialis и O. robiniae) ложной акации, одного из наиболее широко используемых душистых деревьев в ереванских садах были испытаны химико-бак-териальные препараты. Среди средств, применяемых против вредителя E. tibialis, наиболь-шую биологическую эффективность зарегистрировал химический препарат антио (94,0 %) при норме расхода 1,7 л/га и штамм Bt 26-70 при концентрации 3 л/га. (91,0 %). В случае Obolodiplosis robiniae результат был высоким (94,0 %) при норме 1 л/га акпелина, а также при норме 3 л/га концентрата из бактериологических препаратов Bt 26-70 (85,4 %).

This article is the first complete axiomatic presentation of the theory of cognition (epistemology). It presents the axioms of the theory of cognition, the definitions of the concepts and categories used in the text of the theory, and also provides detailed proofs of the propositions (theorems) arising from them. Based on this axiomatic system, evidence-based solutions to the problems (aporias) of the theory of cognition are proposed. This system of axiomatic epistemology can serve as a step in building a rigorous scientific theory of human cognition. The axioms of the proposed system follow the Aristotelian general understanding of the essence of human cognition.

Bacterial collagenolytic proteases have drawn increasing attention due to their essential role in the global nitrogen cycling and their virulent role in some diseases. The inhibition of these enzymes is attractive, as it does not attack the pathogen directly but rather blocks the colonization and infiltration of the host by the clostridia. Optically active non-protein α-amino acids have been screened for their ability to inhibit collagenase of Clostridium histolyticum. Both structure-based drug design approach (modeling) and that of determining enzyme activity in the presence of amino acids have been used to identify low molecular weight inhibitors of collagenase. The compounds able to inhibit collagenase activity have been revealed and IC50 values have been estimated.

In order to optimally manage pension funds, an optimal portfolio is constructed under various constraints. The Sharpe and adjusted Sharpe ratios are calculated. An assessment of the symmetry and spread coefficients of the optimal portfolio yield is made. A sensitivity analysis of the optimal portfolio is performed and founded that when using the Sharpe ratio as a decision criterion, the optimal limit for the country and asset is 35%, while under RA law it is 15%, and the obtained result is stable with respect to symmetry and spread.

The first part of the four-part series of articles on European law starts with basic questions and the foundations of organisational law. The second part explains the legal sources of the European Union law and also deals with the legislative procedures. In addition, the structural principles applicable in the European law are outlined. The third part focuses on the fundamental rights of the European Union, which - in addition to the fundamental freedoms - are the essential individual rights of European primary law. The structural peculiarities from the perspective of the European and constitutional law are described, with a particular focus on the binding effect of the Charter of Fundamental Rights for the Member States. The fourth part explains the fundamental freedoms as the central means for establishing the internal market.

The review briefly presents an analysis of all the priority problems addressed by the author of the monograph H.Zh. Harutyunyan. A focus has been made on the military career of P.S. Boshnagyan and his scientific and socio-political (deputy of the National Assembly of the Republic of Armenia) activities. The book received our high appraisal as an extremely important work, which presents the image of a true citizen of his country, devoted to the ideals of the Motherland. It is no coincidence that the prefaces to the monograph by H.Zh. Harutyunyan were written by prominent figures of our time – Lieutenant-General M.G. Grigoryan, Dean of the Faculty of Geology and Geography M.A. Grigoryan, as well as the Director of the Center of Russian Studies at the Faculty of International Relations of YSU, deputy of the National Assembly of the RA of the 4th convocation A.V. Safaryan.

Our estimates of the cosmological parameters within the ΛCDM model and the model with zero cosmological constant are very different from other studies. The purpose of this report is to draw attention to the difference between our approach and the approaches of other authors and to evaluate the correctness of these approaches.

Результаты проведенного исследования массового серологического тестирования на носительство HBsAg вирусного гепатита среди 6789 беременных женщин, за период с июля 2010г. по июль 2013г., выявили наличие HBsAg в 1,03% (n=70, M±SD=17,5±10,5, 95% CI 15–20). Полная и своевременная вакцинация новорожденных первой дозой вакцины против гепатита В в г.Ереване за 2010-2013гг. достоверно улучшилась (p

The work is devoted to a comparative study of the fatty acid composition of white and black sesame oils, as well as the development of a relatively effective method for isolating the natural antioxidant sesamol. The purpose of this work was to determine the comparative indicators of the content of fatty and free organic acids in the studied oils by gas and high-performance liquid chromatography, confirm their suitability and further use. The optimal conditions for obtaining high-quality unrefined oil from sesame seeds for the food and pharmaceutical industries were determined by the method of cold pressing (pressing chamber temperature was 100℃, oil outlet temperature was ≤ 40℃). Under these conditions, the oil yield was 30% and 27%, respectively. It was shown that finished sesame seed oils contain a highly effective natural antioxidant sesamol (oxyhydroquinone methyl ester) – 0.140 mg/kg, due to which they can be stored at room conditions for more than 3 years. The extracts of squeezes of sesame oils contain valuable free organic acids: oxalic – 0.017 mg/mL, malic – 0.02 mg/mL, fumaric – 0.001 mg/mL. Based on the research, the fatty acid composition of oils was determined and a relatively effective method for the complex processing of sesame raw materials was developed to obtain a highly effective natural antioxidant sesamol.

The article considers the political vector of the constitution as a distinct social approach ensuring social coexistence and establishing a distinct role in the legal system which is based on the prevailing approach of value system. As a starting point, it is accepted that the constitution was purposefully created by the state to achieve a certain level of political dialogue and coexistence, as well as to regulate the value norms of the implementation of political power and as such it needs to have appropriate features. However, the political constitution has gained conceptual significance in legal and political circles over the years. We think that, in the face of democratic changes, it is impossible to oppose the "political" constitution to the "legal" constitution, resulting in a contradiction between the legal and political constitutions. This article discusses the most debatable and controversial conceptual approaches to the political constitution, as well as the peculiarities of the constitution's perception as a political document.

Aim. The aim of the work is to study the biodiversity of certain invertebrates (Insecta, Molluska) of the Azat River gorge and their ecological and biological features.Material and Methods. Invertebrates collected in the Garni‐Goght‐ Geghard section of the Azat River gorge in the period from 2015 to 2021 served as study material.The work was carried out at the Scientific Center for Zoology and Hydroecology of the National Academy of Sciences of the Republic of Armenia. Our own collections have been used as material, as well as collections of insects and mollusks of the Institute of Zoology.Results. As a result of studies of the species composition of invertebrates of the Azat River gorge (Geghard, Goght, Garni) we found: 25 species of horseflies (Tabanidae: Diptera), 24 species of phytophagous gall midges (Cecidomyiidae: Diptera); 13 aphid species (Aphididae: Hymenoptera); 17 pyralid moth species (Crambidaе: Lepidoptera) from 5 subfamilies (Crambinae, Evergestinae, Pyraustinae, Spilomerlinae, Glaphyriinae); 19 species of mollusks (Molluska): 3 species of freshwater mollusks from 3 families (Physidae, Planorbidae, Ancylidae), 16 species of terraneous mollusks from 10 families (Succineidae, Vertiginidae, Orculidae, Pupillidae Valloniidae, Enidae, Vitrinidae, Endodontidae, Limacidae, Helicida). The bioecological features of these insects and mollusks have been studied and distribution by biotopes, revealing changes in the species composition of some groups due to anthropogenic factors.Conclusion. As a result of the researches undertaken, a wide variety of invertebrates has been frevealed. They occupy all ecological niches and are found in all plant formations of the Azat River gorge. Most of the insect species are of economic importance. Research on invertebrates of the Azat river gorge is very promising. Works in this direction will be continued with the involvement of new research groups.

The purpose of the study is to analyze and identify the main trends in computer game advertising and its design. Research of functional and visual features of the design of certain types of Internet advertising. Methodology. The research methodology is based on a systematic analysis of scientific works mainly thematically related to Internet advertising and the features of its design for different platforms. Visual analytical, comparative, and monographic methods of scientific analysis of sources are used in this paper. Results. The current trends in advertising, which are most relevant for the gaming industry today, were studied. Therefore greater emphasis has been placed on the three most popular and relevant to the game field types of online advertising and their graphic design features. Based on the analysis of scientific works and responses from people on Internet sites, a significant interest in Internet advertising was found in contrast to traditional form of advertising, namely the banner, video advertising and blogging. The features, advantages, and disadvantages of each of these types of online advertising have been identified. It has been clarified which aspects in the design of these types of advertising are important. The reasons for the success of the use of these types of online advertising in the field of games and their psychological impact on the consumer are analyzed. The importance of the right approach to the design of these types of advertising is determined. Scientific novelty of the research lies in summarizing previous research on this topic and identifying the features of certain types of online advertising, structuring information about the advantages and disadvantages of each, identifying the design features of each type, as well as analyzing the reasons for their success in gaming and the role of graphic design in this. Practical significance. Research materials can be used as a theoretical basis for the creation of projects related to computer games advertising. Researched information and scientific materials of various authors allowed us to create an informative article, the content of which can be useful in developing appropriate design projects and choosing the direction of advertising for them.

There has been a considerable amount of interest in the study of idioms. English is a language with a vast idiomatic basis, which makes its learning very exciting and intriguing. Idioms, constitute a notoriously difficult area of foreign language learning and teaching. The sheer number of idioms and their high frequency in discourse make idioms an important aspect of vocabulary acquisition and language learning in general. Nowadays language learning is based on the need for interaction with others. This research aims to respond to a need for a proper method of teaching election idioms to High School students. From the growing body of this research, it follows that applying cooperative techniques for teaching election idioms, can improve learning outcomes and can also effectively improve language communication. The results of the pre-test and pro-test show that the cooperative method of teaching election idioms turned out to be more effective than the competitive method in both idioms comprehension and production.

We measure cross sections of proton-induced reactions on tin up to energies of 18 MeV using the stacked-foil activation technique, and report first experimental values for 114Sn(p,{\alpha})111In, {^{120}}Sn(p,{\alpha})117gIn, and 114Sn(p,x)113Sn reactions. Measured cross sections have been compared to existing experimental values and numerical calculations based on Talys1.95. Our data are in good agreement with all previous experiments, and also with Talys1.95 results except for 120Sn(p,{\alpha})117m,gIn reactions where the numerical calculations are shifted to higher energies. We also measure isomeric cross section ratios for 117m,gIn and 120m,gSb pairs as functions of the incident proton energy., Comment: 21 pages, 9 figures, 3 tables

The work presents the mathematical apparatus for analytical calculation of the magnetic parameters of the working points and the magnetic field outside the magnetic pole of a cylindrical permanent magnet, magnetized separately in length and according to the application of the magnetic system, as well as of the dimensions of the permanent magnet. New expressions have been introduced into the calculation theory. The graphical connection of magnetic field parameters, data from the analytical and experimental studies, interpretations, and conclusions are presented.

The paper presents the structure, the operation principle, the main dynamic characteristics, the electrical circuits of the magnetic systems replacements, the features of the magnetic system, the characteristics and operating points of the permanent magnet-electromagnet of the induction generator.

Made of a thin non-superconducting metal (N) sandwiched by two superconductors (S), SNS Josephson junctions enable novel quantum functionalities by mixing up the intrinsic electronic properties of N with the superconducting correlations induced from S by proximity. Electronic properties of these devices are governed by Andreev quasiparticles [1] which are absent in conventional SIS junctions whose insulating barrier (I) between the two S electrodes owns no electronic states. Here we focus on the Josephson vortex (JV) motion inside Nb-Cu-Nb proximity junctions subject to electric currents and magnetic fields. The results of local (Magnetic Force Microscopy) and global (transport) experiments provided simultaneously are compared with our numerical model, revealing the existence of several distinct dynamic regimes of the JV motion. One of them, identified as a fast hysteretic entry/escape below the critical value of Josephson current, is analyzed and suggested for low-dissipative logic and memory elements., Comment: 11 pages, 3 figures, 1 table, 43 references

The paper analyzes Turkish involvement in Eastern Africa by the case of Turkey-Somalia relations. The article represents how Turkey successfully went from providing humanitarian aid to taking control over the important infrastructures and locating own military base in Somalia. The research shows that the Turkish involvement in Somalia is mainly benefiting Turkey rather than Somalia, which does not possess enough resources to speak on equal terms with Turkey. The conclusions drawn from the research are the following: 1) Africa’s role as a political theatre is gradually increasing, as more and more players are getting involved, 2) Turkey is getting actively engaged in Africa on its way to becoming a regional power, 3) The case of Turkish involvement in Somalia represents a “Turkish model” that can be offered to struggling states of Africa, i.e. large economic and political involvement in exchange for communication and military infrastructure 4) Somalia’s case can become a motivation for other unstable countries in the region in search for a patron state.

The international and political situation that came into existence after World War I dictated to the Armenian political forces to reconsider their programs and practices. The Reorganized Hunchakian Party, which was dedicated to the liberation of Western Armenians and advocated liberal ideas, adopted the name “Nationalist-Liberal”. The Liberals believed that the Armenian state that would unite the Republic of Armenia, Western Armenia and Cilicia, should have a presidential system of government and temporarily accept the patronage of a great power. The party played a significant role in Armenian social and political life in 1917-1921. After the establishment of the Soviet regime in Armenia, the ideological differences between the Liberals and the Soviet government did not disappear, however, the party’s priority became to help Armenia, which continued after the unification of the Liberals and the Ramgavars.

Aim. The aim of this work is the study of the specifics of accumulation of heavy metals in the body of gastropod mollusks ‐ slugs (Molluska: Limacidae) on the southern slope of the Aragats mountain range, namely, conducting a quantitative analysis of heavy metals in the soil of different points of the Aragats mountain range and in the body of slugs (Vitrinoides monticola armeniaca; Deroceras caucasicum; Limax flavus), as well as the principles of biogenic migration of heavy metals according to the soil– plant–animal system (slugs) and determining the role of slugs in this migration in terrestrial ecosystems.Material and Methods. Slugs collected from different points of the southern slope of the Aragats mountain range served as material for this study. The content of heavy metals (Cu, Zn, Pb, Ca, Mo) in the body of the mollusks was determined by the Atomic Absorption Spectrophotometry method: AAS extraction & ISO‐8288. The features of the biological accumulation of heavy metals in the body of mollusks were also determined.Results. Gastropod mollusks (Molluska: Limacidae) actively accumulate heavy metals (especially Cu, Zn, Ca) in their bodies and play a certain role in their transfer through food chains. Slugs, living in upper soil horizons (mesofauna) and under stones and plant litter, actively respond to the slightest changes in the environment and are perspective objects allowing the detection of deviations in the functioning of soils and the natural complex as a whole.Conclusion. Slugs living in the soil are an important link of the biogenic migration of heavy metals. An inverse relationship was revealed between the total and removable number of heavy metals in migration through the system: soil–plant–organism.

Introduction: Armenia is an upper-middle-income country with a population of nearly 3 million. Stroke is one of its major public health problems and ranks as the sixth leading cause of death, with a mortality of 75.5 per 100,000. Methods and results: Until recently, modern stroke care was not available in Armenia. During the past 8 years substantial advances have been made in building medical infrastructure and delivering acute stroke care. This manuscript describes contributors to this progress, including extensive and long-term collaboration with international stroke experts, the development of hospital-based stroke teams, and a funding commitment for stroke care by the government. Conclusion: The results of acute stroke revascularization procedures during the past 3 years are reviewed and found to meet international standards. Future directions are discussed including the immediate need to expand acute stroke care to underserved parts of the country by adding primary and comprehensive stroke centers. An active educational program for nurses and physicians and the TeleStroke system development will help support this expansion.

The article describes new types of air ionizers designed in the “Acoustophysics” laboratory of the Institute of Applied Problem of Physics of the National Academy of Sciences of the Republic of Armenia. These types of ionizers are created not only for the purpose of cleaning the air in the living and industrial areas from dust, but also fight against different types of viruses, which is especially important during periods of pandemics. The justification of the efficiency of aeroionization is given. The safety of using the developed ionizers has been shown even with continuous operation for a long time. A completely new method for testing the effectiveness of the developed ionizers is also described in detail.

Mechanical methods of deployment of permanent, continuous analog visible recording of signals complicate the design of analog recorders and light–beam oscilloscopes with the continuous visible recording of low–frequency processes and periodic output of recording frames, reduce their reliability and accuracy, make it difficult to adjust deployment steps, increase power and dimensions, and also lead to additional geometrical and optical errors in light–beam oscilloscopes. To eliminate these shortcomings, electronic methods for deployment of continuous analog visible recording are proposed and analysed, on the basis of which corresponding devices are also developed, created, and tested, with the help of which the proposed electronic methods are tested and verified based on ASEO type Automatic seismic electrographic oscilloscopes.

Blood plasma albumin (bovine serum albumin, BSA) interaction with a biologically active reagent 4-hydroxy-2-methylquinoline (4H2MQ) has been studied using fluorescence spectroscopy methods (steady state, synchronous, excitation/emission matrix, 3D spectra). With the addition of 4H2MQ, no changes in the spectral characteristics of BSA (fluorescence emission intensity and λmax position) are observed; only the symmetry of the BSA emission spectrum is changed and the full width at half maximum is decreased. The analysis of synchronous and 3D fluorescence spectra showed the existence of three emitting species in this system, which could be a result of changes in the fluorescence and photochemical properties of 4H2MQ.

Սույն հոդվածի շրջանակներում ուսումնասիրության առարկա է դարձել պաղեստինյան հակամարտության կարգավորման գործընթացում «երկու արաբական և հրեական պետությունների ստեղծման» հայեցակարգը, որը առաջարկվելով 1940-ական թթ., արդիական է մնում մինչ օրս

The article summarizes information on the penetration and spread of 14 most dangerous or potentially dangerous invasive alien species throughout the territory of Armenia, which threat biodiversity, natural ecosystems and, to some extent, public health. It is shown that eight of the fourteen species were intentionally introduced into Armenia as ornamental plants or for use in landscaping settlements and shelterbelts along the roads and railways. Five of these species are woody plants. Four species appeared on the territory of the republic as a result of their self-dispersal and two species penetrated by accidental introduction. It is noted that the degree of threat to biodiversity and natural ecosystems is shown as “high” for seven species, as “very high” for four species, and three species are listed as “potentially invasive”. However, one species ( Ambrosia artemisiifolia ) is listed as a “very high” threat to public health. The article indicates the absolute need for an examination of the threat of invasion when planning the introduction of plants for the purpose of growing them in open ground, first of all, when creating plantations and using them in landscaping settlements and when creating or restoring damaged forest ecosystems and protective forest belts.

IntroductionGlobal cerebral ischemia leads to substantial and irreversible damage of brain tissue. As it progresses in a less severe course, certain strategies should be implemented to screen this condition on its early onset. The research aimed to characterize the local field potential (LFP) alterations recorded during the subacute phase of the cerebral ischemia animal model and provide their predictive power.MethodsThe extracellular signal recordings from the parietal cortex of animals were registered with a neural probe. The signal was amplified, filtered, digitized, and acquired with Intan amplifier and USB interface boards. The recordings were obtained both in normal conditions and after implementation of unilateral common carotid artery occlusion. The data analysis and classification were performed using NI Diadem software and custom-written code in IPython environment. The respective morphological changes were screened in cerebral cortex and hippocampus. The whole-brain slicing and TTC staining were used for infarct size evaluation.ResultsIn Fourier spectrograms of intact brain recordings, a peak at 14.4-15 Hz frequencies was detected, whereas this phenomenon was absent in cerebral ischemia model recordings. In channels’ cross-correlograms for intact and ischemic brain recordings, there was a clear difference detected in the maximum peak power. With autocorrelation analysis, the long lag rhythmicity was detected in normal brain recordings, while no rhythmicity was observed in ischemic brains. The morphological and behavioral analyses did not result in any significant changes and neural loss. The TTC staining failed to show any damaged area ipsilateral to the occluded common carotid artery.ConclusionWe have analyzed and described the major characteristics of the electrical activity that vary between neural populations of the parietal cortex of normal and ischemic brains. This data proves that LFP recordings can be used for further investigation of changes occurring in the subacute phase after unilateral common carotid artery occlusion.

The real-time monitoring of the seismicity of the territory of the Taurus-Caucasus region shows that at present, since 2021, geodynamic processes of significant intensity have been taking place in the earth's crust of the Taurus-Caucasus region, which can form anomalous areas of increased seismotectonic deformations on separate segments of seismically active faults. The article studies the activation of weak seismicity in the study area during the period of instrumental observations from 2021 to the present. The structure of the set of sources of weak earthquakes in five-dimensional space (hypocenter, time, energy) is considered. Based on the methods of statistical analysis of instrumental data, clusters of earthquake sources interconnected in space and time with magnitudes M≥3.0 (Figure 1).Figure 1.A detailed analysis shows that almost all types of anomalous manifestations of seismicity (swarms, earthquake doublets, pseudo-gaps, etc.) are observed in the same period in the Taurus-Caucasus region. It was revealed that during the same period, the earthquake epicenters in real time line up mainly along trajectories that have a quasi-perpendicular direction with respect to the main seismically active faults of the Caucasus strike. In the same period, in the Tavrokavkaz region, there is an alternation of seismotectonic stress variations in tense series of earthquakes in the magnitude range M=3.0-5.4 by sequential occurrence in the region of Eastern Turkey, Northern Armenia, Iran, Azerbaijan and the Greater Caucasus. The results obtained indicate that in the Taurus-Caucasus region there are regional and local significant changes in the stress-strain state of the earth's crust that are complex in their manifestation, which must be taken into account in a detailed study of seismic geodynamic processes in the Taurus-Caucasus region in order to identify possible zones of occurrence of strong earthquakes and medium-term earthquake forecast. This work was funded by the Science Committee of the Republic of Armenia, as part of the research project (No. ACH-01/22, 21SCG-1E021).

CAR T cell-based therapies have revolutionized the treatment of hematological malignancies such as leukemia and lymphoma within the last years. In contrast to the success in hematological cancers, the treatment of solid tumors with CAR T cells is still a major challenge in the field and attempts to overcome these hurdles have not been successful yet. Radiation therapy is used for management of various malignancies for decades and its therapeutic role ranges from local therapy to a priming agent in cancer immunotherapy. Combinations of radiation with immune checkpoint inhibitors have already proven successful in clinical trials. Therefore, a combination of radiation therapy may have the potential to overcome the current limitations of CAR T cell therapy in solid tumor entities. So far, only limited research was conducted in the area of CAR T cells and radiation. In this review we will discuss the potential and risks of such a combination in the treatment of cancer patients.

The article aims at examining the tribal features of Turkishness in the novels of Hakob Oshakan, a Western Armenian writer who survived the Genocide. In our deep conviction,the highest achievement of Oshakan's artistic system, together with it being a novel, cultural studies, ethics, psychoanalysis and ideology, is the novel of the Armenian Cause and the Armenian Genocide. as a collective concentration of national characteristics and a precursor to the Armenian Genocide,Turkishness is brought into action in all of Oshakan's works with multi-level manifestations. The research is carried out to reveal two main issues: the psychology and senses of actions of the Turkish tribal type and the mentality of Turks. The analysis of Turkish tribal biological psychology leads Oshakanto the general idea that Turks are thirsty for blood and violence, and that Turkishness is a terminal cancer spread over the lives of the Armenian people. According to Oshakan, the psychology of extermination and occupation reaches the level of national doctrine in Turkey. The Turks took over the Armenian and Byzantine historical lands through genocide, forcibly Turkified the Christian civilization, and forced the Christian masses to convert. As an unbreakable bigotry the tribal archetype of Turks is passed down from generation to generation, and the chronology of time documents the sad reality that Turks will never change., References: 1. Օշական Յ., Համապատկեր արեւմտահայ գրականութեան, հատ. Ժ, Անթիլիաս, 1982, 646 էջ (Oshakan H. (1982): "Overview of Western Armenian literature", vol.10, Antelias, p. 646): 2. Օշական Յ., Մայրիներու շուքին տակ, Գրական զրոյց Յ. Օշականի հետ, Պէյրութ, 1983, 152 էջ (Oshakan H. (1983): "Under the cedar tree". A literary conversation with H. Oshakan, Beirut, p. 152): 3. Օշական Յ., Մնացորդաց, հատ. Ա, Անթիլիաս, 1988, 551 էջ (Oshakan H. (1988): "Mnatsordats", vol. 1, p. 551): 4. Օշական Յ., Մնացորդաց, հատ. Բ, Անթիլիաս, 1988, 533 էջ (Oshakan H. (1988): "Mnatsordats", vol. 2, p. 533): 5. Օշական Յ., Մնացորդաց, հատ. Գ, Անթիլիաս, 1988, 622 էջ (Oshakan H. (1988): "Mnatsordats", vol. 3,Antelias, p. 622): 6. Տասնապետեան Շ., Յակոբ Օշականի վէպը, Պէյրութ, 1994, 127 էջ (Tasnapetyan Sh. (1994): "Hakob Oshakan's Novel", Beirut, p. 127): 7. Օշական Յ., Հարիւր մէկ տարուան, Անթիլիաս, 1996, 472 էջ (Oshakan H. (1996): "One hundred and one years", Antelias. P. 472)