1. Effect of polybrominated biphenyls on renal tubular transport of organic ions
- Author
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Evers Wd, Hook Jb, and Bond Jt
- Subjects
Niacinamide ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Polybrominated Biphenyls ,Intraperitoneal injection ,Kidney ,Toxicology ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Ion transporter ,chemistry.chemical_classification ,Adult female ,Organic base ,Chemistry ,Biphenyl Compounds ,Body Weight ,Organ Size ,Lipid Metabolism ,Pollution ,Rats ,Kidney Tubules ,Endocrinology ,Liver ,Biochemistry ,Renal tubular transport ,Female ,p-Aminohippuric Acid ,Xenobiotic ,Organic acid - Abstract
Polybrominated biphenyls (PBBs) entered the food supply in 1973 and have since been shown to be toxic to animals. PBBs stimulate renal mixed function oxidase in developing rats. Since the renal organic ion transport systems are important in the elimination of several xenobiotics from plasma, further investigations of the renal effects of PBBs were conducted. Adult female rats were given a single intraperitoneal injection of 130–165 mg PBBs/kg body weight. After J day there was a significant increase in total liver lipids. The liver weight/body weight ratio was higher after 8 days in the PBB‐treated animals. These changes were still apparent 48 days after injection, when the study was terminated. Kidney weight was not altered by treatment, nor was accumulation by renal cortical slices of the organic base N‐methylnicotinamide (NMN). Uptake of the organic acid p‐aminohippuric acid (PAH) appeared to be elevated throughout the study, but this was only significant at 32 days after injection. Direct exposure of ...
- Published
- 1977
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