272 results on '"Hiroyuki Koga"'
Search Results
2. Upper Ureteral Reconstruction with a Tapered Descending Colon after Failed Pyeloplasties in a 13-Year-Old Boy
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Hideaki Nakajima, Hiroyuki Koga, Seitaro Kosaka, Mao Ikari, Geoffrey J. Lane, and Atsuyuki Yamataka
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Fuel Technology ,Process Chemistry and Technology ,Economic Geology - Abstract
An 11-year-old boy was referred for further management of a 6-cm-long grossly stenosed ureter following two failed left ureteropelvic junction (UPJ) obstruction repairs elsewhere. A tapered segment of the descending colon (TDC) was used successfully for ureteral reconstruction. The UPJ was exposed through a left flank incision. The stenosed segment was excised; both ends appeared severely inflamed and thickened. Tissue interposition was required and ureteroplasty with a TDC was performed by incising the peritoneum adjacent to the excised ureter to mobilize the descending colon to the retroperitoneal space. To prepare the TDC, an 8-cm segment of the colon with intact blood vessels was isolated, tapered, and sutured into a funnel shape using a 14-Fr catheter as a temporary stent. After colocolostomy, the colon was returned to the abdominal cavity, the peritoneum was closed carefully to prevent vascular compromise, and the TDC was anastomosed to the ureter and renal calyx with interrupted absorbable sutures. A double J stent (DJS) and percutaneous nephrostomy tube were placed. Postoperative recovery was uneventful. The DJS was removed on day 50 after confirming smooth urine flow through both the ureter–TDC and calyx–TDC anastomoses. Diuretic renography performed 68 days postoperatively was unobstructed. The patient is currently well after 12 months follow-up. This would appear to be the first report of a TDC being used to create a funnel-shaped segment to reconstruct a long, grossly stenosed ureter. The TDC is simpler than the re-tubularizing colon but requires monitoring for postoperative mucus-related complications and malignant transformation.
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- 2023
3. A Case of Eosinophilic Otitis Media Implanted with Bone-Anchored Hearing Aid
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Hiroyuki Koga, Akira Ganaha, Takeshi Nakamura, Takashi Goto, and Tetsuya Tono
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Otorhinolaryngology - Published
- 2023
4. Time-Lapse Analysis of Chromosome Behavior in Arabidopsis thaliana Pollen Mother Cells Using pAtDMC1:H2B:GFP Fusion Gene Showed Chromosome Movement and Conformational Change at Meiosis
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Mayumi Shibata, Shun Nakagawa, Makoto Shimizu, Hiroyuki Koga, Misato Fujita, Tsuyoshi Nakagawa, and Yoshitaka Azumi
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Genetics ,Animal Science and Zoology ,Cell Biology ,Plant Science - Published
- 2022
5. Retroperitoneoscopic Surgery in Children Does Not Cause Pathological Desaturation in Cerebral/Renal Oxygenation on Near-Infrared Spectroscopy Compared with Laparoscopic and Thoracoscopic Surgery
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Yuichiro Miyake, Kentaro Fujiwara, Kumi Kataoka, Takanori Ochi, Shogo Seo, Hiroyuki Koga, Geoffrey J. Lane, Kinya Nishimura, Masakazu Hayashida, and Atsuyuki Yamataka
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Surgery - Published
- 2022
6. Biochemical Evaluation of Laparoscopic Portoenterostomy for Treating Biliary Atresia and Redo for Failed Portoenterostomy
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Takafumi Tsukui, Hiroyuki Koga, Joel Cazares, Shunsuke Yamada, Hiroshi Murakami, Soichi Shibuya, Hiroki Nakamura, Takanori Ochi, Koichi Tsuboi, Geoffrey Lane, Nana Tanaka, Go Miyano, Tadaharu Okazaki, Masahiko Urao, and Atsuyuki Yamataka
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Surgery - Published
- 2022
7. Quality of life after type-A esophageal atresia surgery: changes over time and effect of pre-anastomotic elongation
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Go, Miyano, Toshiaki, Takahashi, Susumu, Yamada, Koichi, Tsuboi, Shunsuke, Yamada, Seitaro, Kosaka, Keiichi, Morita, Shogo, Seo, Takanori, Ochi, Hiroyuki, Koga, Tsubasa, Takahashi, Koji, Fukumoto, Naoto, Urushihara, Tadashi, Hatakeyama, Tadaharu, Okazaki, Toshihiro, Yanai, Geoffrey J, Lane, and Atsuyuki, Yamataka
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Adult ,Postoperative Complications ,Treatment Outcome ,Adolescent ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Humans ,Surgery ,General Medicine ,Child ,Esophageal Atresia ,Tracheoesophageal Fistula - Abstract
To assess mid-/long-term postoperative quality of life (QOL) of esophageal atresia (EA) patients.Modified gastrointestinal quality-of-life index surveys were administered to postoperative EA patients who were at least 7 years old at evaluation to assess three topics about general lifestyle (GL), five topics about EA, and four topics about mental health (MH). For MH, caregivers were also interviewed, but separately. Subjects were divided according to age: children (7-12 years old), teenagers (13-19), and adults (20 and over) and compared according to Foker or Kimura elongation (FK) or bougienage stretching (BS).There were 22 patients evaluated. Responses for GL, EA, and MH did not differ significantly between age groups, but MH responses by caregivers for subjects who were children or teenagers scored significantly lower than responses they made themselves. For primary esophageal elongation technique (PET), age at esophagoesophagostomy was significantly higher in FK. Despite FK scoring 15.1 versus 12.4 for BS during EA evaluation, this difference was not statistically significant.Changes in QOL responses according to age were unremarkable. However, discrepancies in MH indicate that subjects felt better than their caregivers thought. PET did not appear to influence QOL.
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- 2022
8. Oxicam-type nonsteroidal anti-inflammatory drugs enhance Agrobacterium-mediated transient transformation in plants
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Seung-won Choi, Kie Kumaishi, Reiko Motohashi, Harumi Enoki, Wiluk Chacuttayapong, Tadashi Takamizo, Hiroaki Saika, Masaki Endo, Tetsuya Yamada, Aya Hirose, Nobuya Koizuka, Seisuke Kimura, Yaichi Kawakatsu, Hiroyuki Koga, Emi Ito, Ken Shirasu, and Yasunori Ichihashi
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Plant Science ,Agronomy and Crop Science ,Biotechnology - Published
- 2022
9. Hearing Outcome and Predictors after Implanting Bone Conduction or Middle Ear Implants in Ears with Refractory Otitis Media
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Tono, Sho Kurihara, Takeshi Nakamura, Kan Kubuki, Hiroyuki Koga, Takashi Goto, Shouken Shimoara, Akira Ganaha, Yuusuke Yamada, Kuniyuki Takahashi, and Tetsuya
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bone conductive implant ,middle ear implant ,refractory otitis media ,Baha ,Vibrant Soundbridge ,conductive hearing loss ,mixed hearing loss - Abstract
Bone conduction implants (BCIs) and middle ear implants (MEIs) are promising options for individuals with persistent chronic inflammation of the middle or outer ear. However, the structure of the middle ear is often altered in patients who undergo mastoidectomy or posterior wall removal for refractory otitis media, leaving uncertainty regarding the efficacy of hearing devices. Only a few studies have examined auditory outcomes based on the etiology of hearing impairment. We investigated hearing outcomes, including speech audiometry, in patients who underwent implantation after surgery for refractory otitis media. Our findings indicated that patients who received BCIs or MEIs achieved favorable hearing outcomes. Furthermore, a correlation was observed between the preoperative bone-conduction threshold at 1 kHz in the better ear and the sound-field threshold at 1 kHz with BCIs, whereas no correlation was observed between the preoperative bone-conduction threshold and the sound-field threshold with MEIs. This study highlights the positive impact of BCIs and MEIs in patients who undergo implantation after surgery for refractory otitis media. Additionally, our study identified parameters that predict postoperative efficacy.
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- 2023
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10. Biopsy Diagnosis of Hirschsprung's Disease Using a Single Excisional Biopsy Based on the Anorectal Line
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Masahiro Takeda, Takanori Ochi, Hiroyuki Koga, Koichi Tsuboi, Atsushi Arakawa, Geoffrey J. Lane, and Atsuyuki Yamataka
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Pediatrics, Perinatology and Child Health ,Surgery - Abstract
Introduction A biopsy protocol for diagnosing Hirschsprung's disease (HD) in children using the anorectal line (ARL). Materials and Methods The ARL was adopted for diagnosing HD in 2016 using two excisional submucosal rectal biopsies performed at different levels, sequentially; the first just above the ARL and the second, further proximal (2-ARL). Currently, only the first-level biopsy is performed (1-ARL) and examined intraoperatively. Management was observation if normoganglionic, pull-through if aganglionic, and a second-level biopsy if hypoganglionic. Hypoganglionosis was considered physiologic if the second-level biopsy was normoganglionic and pathologic if hypoganglionic. Colon caliber change and bowel obstructive symptoms reflect the severity of hypoganglionosis. Results For 2-ARL (n = 54), results were: normoganglionosis (n = 31/54; 57.4%), aganglionosis (n = 19/54; 35.2%), and hypoganglionosis (n = 4/54; 7.4%); physiologic (n = 3/54; 5.6%) and pathologic (n = 1/54; 1.9%). Normoganglionosis and aganglionosis were always duplicated in 2-ARL (kappa = 1.0). For 1-ARL (n = 36), results were: normoganglionosis (n = 17/36; 47.2%), aganglionosis (n = 17/36; 47.2%), and hypoganglionosis (n = 2/36; 5.6%). Second-level biopsies were normoganglionic (physiologic: n = 1) and hypoganglionic (pathologic: n = 1). All normoganglionic cases, except one, resolved conservatively. All aganglionic cases had pull-through with HD confirmed on histopathology. Both pathologic hypoganglionic cases had caliber change and severe obstructive symptoms as definitive indications for pull-through with hypoganglionosis of the entire rectum confirmed on histopathology. Physiologic hypoganglionic cases were observed and currently have regular defecation. Conclusion Because the ARL is an objective functional, neurologic, and anatomic demarcation, normoganglionosis and aganglionosis can be diagnosed accurately with a single excisional biopsy. Only hypoganglionosis requires a second-level biopsy.
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- 2023
11. Experimental validation of the mechanism of stomatal development diversification
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Yuki Doll, Hiroyuki Koga, and Hirokazu Tsukaya
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Stomata are the structures responsible for gas exchange in plants. The established framework for stomatal development is based on the model plant Arabidopsis, but diverse patterns of stomatal development have been observed in other plant lineages and species. The molecular mechanisms behind these diversified patterns are still poorly understood. We recently proposed a model for the molecular mechanisms of the diversification of stomatal development based on the genusCallitriche(Plantaginaceae), according to which a temporal shift in the expression of key stomatal transcription factors SPEECHLESS and MUTE leads to changes in the behavior of meristemoids (stomatal precursor cells). In the present study, we have tried to validate this model through genetic manipulation experiments on Arabidopsis. By altering the timing of MUTE expression, we successfully generated Arabidopsis plants with early differentiation or prolonged divisions of meristemoids, as predicted by the model. The epidermal morphology of the generated lines resembled that of species with prolonged or no meristemoid divisions. Thus, the evolutionary process was reproduced via shifting MUTE expression. We also observed unexpected phenotypes, which indicated the participation of additional factors in the evolution of the patterns observed in nature. This study provides novel experimental insights into the diversification of meristemoid behaviors.HighlightGenetic manipulation in Arabidopsis uncovered how changes in temporal gene expression patterns lead to the diversification of stomatal patterns, providing new experimental insights into the evolution of stomatal development.
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- 2023
12. Successful all robotic‐assisted excision of highly malignant mediastinal neuroblastoma in a toddler: A case report
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Takanori Ochi, Hiroyuki Koga, Hiroyasu Ueno, Junya Fujimura, Seitaro Kosaka, Yuichiro Miyake, Shiho Yoshida, Geoffrey J. Lane, Kenji Suzuki, and Atsuyuki Yamataka
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General Medicine - Published
- 2023
13. Retroperitoneoscopic Pyeloplasty for Ureteropelvic Junction Obstruction in Children: Value of Robotic Assistance
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Hiroyuki Koga, Hiroshi Murakami, Shogo Seo, Takanori Ochi, Hiroki Nakamura, Yuichiro Miyake, Seitaro Kosaka, Masahiro Takeda, Naho Fujiwara, Rumi Arii, Koichi Tsuboi, Geoffrey J. Lane, and Atsuyuki Yamataka
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Pediatrics, Perinatology and Child Health ,Surgery ,General Medicine - Published
- 2023
14. Mid-term outcome of postoperative biliary atresia patients according to level of transection of the biliary remnant and depth of suturing
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Eri, Abe, Hiroyuki, Koga, Hiroki, Nakamura, Takanori, Ochi, Shogo, Seo, Geoffrey J, Lane, and Atsuyuki, Yamataka
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Biliary Atresia ,Cholangitis ,Pediatrics, Perinatology and Child Health ,Humans ,Infant ,Jaundice ,Portoenterostomy, Hepatic ,Surgery ,Postoperative Period ,General Medicine - Abstract
Open portoenterostomy (PE) for biliary atresia (BA) is currently more extended (EP) than the original (OP). Typical OP techniques, shallow transection of the biliary remnant and shallow suturing, both lost in EP, were revived as a modified procedure (MP). Postoperative outcomes of EP and MP were compared.Subjects were 55 consecutive BA patients treated by EP (n = 18) or MP (n = 37) at a single center between 2004 and 2021.Mean follow-up duration was: MP: 15.5 years (range 0.1-12.3 years) and EP: 15.5 years (range 0.38-17.1 years). The ratio of jaundice free (JF; total bilirubin ≤ 1.2 mg/dL) subjects was significantly higher in MP (78.4%) versus EP (50%); p 0.05, the incidence of bile lakes at the porta hepatis was significantly higher in MP (7/37: 18.9%) versus EP (0/18: 0%); p 0.05, and Kaplan-Meier analysis showed JF survival with the native liver (JF + SNL) was significantly better in MP (26/37: 70.2%) versus EP (4/18: 22.2%); p 0.05. All other criteria were similar. Of note, time taken to become JF and the incidence of cholangitis were not significantly different.Shallow transection and shallow suturing would appear to influence postoperative outcome. The etiology of bile lake formation in MP requires urgent confirmation.
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- 2022
15. Levator ani asymmetry and deviation in high-type anorectal malformation evaluated by magnetic resonance imaging
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Yuichiro Miyake, Takanori Ochi, Yuki Yamashiro, Shogo Seo, Go Miyano, Hiroyuki Koga, Geoffrey J. Lane, Ryohei Kuwatsuru, and Atsuyuki Yamataka
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Pediatrics, Perinatology and Child Health ,Rectum ,Humans ,Surgery ,Pelvic Floor ,General Medicine ,Child ,Magnetic Resonance Imaging ,Anorectal Malformations - Abstract
The levator ani (LA) complex in high-type imperforate anus (H-IA), low-type imperforate anus (L-IA), and Hirschsprung's disease (HD) patients as controls were documented using magnetic resonance imaging (MRI) and compared for symmetry.Mean left:right LA thickness ratio (LA ratio), and deviation of the LA from the pubococcygeal line (PCL; LA angle) were calculated from thin-slice MRI images (axial 2 mm, coronal 2 mm, and sagittal 3 mm) of the puborectalis and pubococcygeus taken parallel to the PCL under sedation in H-IA (n=14), L-IA (n=16), and HD (n=9).MRI scans were performed between January 2018 and June 2021. LA were significantly thinner in H-IA (1.78±0.46 mm) compared with L-IA (2.97±0.55 mm) and controls (2.87±0.32 mm), p0.0001. LA ratio was significantly lower in H-IA (0.71±0.15) compared with L-IA (0.93±0.04), and controls (0.91±0.06), p0.0001. Mean LA-angle was significantly different in H-IA, 10.8° (range 6°-19°), versus L-IA and controls, both zero degrees (range 0°-5°), p0.0001, respectively.LA was confirmed to be significantly asymmetric in H-IA. Because outcome of surgical repair involving a midline incision, such as posterior sagittal anorectoplasty could be impaired, pediatric surgeons are advised to plan surgical intervention for H-IA carefully and appropriately.
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- 2022
16. Optimization of Waste Treatment Planning in Intermediate Treatment Facilitates
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Yusuke Ito, Taiki Abe, Hiroyuki Koga, Atsushi Fujiyama, and Toru Matsumoto
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- 2022
17. 気孔の生態進化発生生物学: 気孔発生の多様性とその進化
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Yuki Doll, Hiroyuki Koga, and Hirokazu Tsukaya
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General Engineering - Published
- 2022
18. Choledochal Cyst
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Hiroyuki Koga and Atsuyuki Yamataka
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- 2023
19. Cadaver Training for Minimally Invasive Pediatric Surgery: A Preliminary Report
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Haruki Kato, Geoffrey J. Lane, Masafumi Tanaka, Go Miyano, Makoto Takahashi, Atsuyuki Yamataka, Takanori Ochi, Hiroyuki Koga, Kazuhiro Sakamoto, Koichiro Ichimura, Michiaki Ikegami, Shiho Yoshida, and Shogo Seo
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medicine.medical_specialty ,Swine ,business.industry ,Hepaticoduodenostomy ,Pediatric Surgeon ,Surgical training ,Specialties, Surgical ,Surgery ,Cadaver ,Preliminary report ,Ureteroureterostomy ,Invasive surgery ,Pediatric surgery ,medicine ,Animals ,Humans ,Minimally Invasive Surgical Procedures ,Laparoscopy ,Clinical Competence ,Child ,business - Abstract
Aim: To report the value of adult cadavers for training in minimally invasive surgical (MIS) techniques for pediatric surgery (PS). Materials and Methods: Three teams, each consisting of a board-certified consultant pediatric surgeon (CS), a senior trainee (ST), and a junior trainee (JT), attended a cadaver surgical training (CST) course involving five procedures: thoracoscopic esophagoesophagostomy (TEE), thoracoscopic right lower lobectomy (TRL), laparoscopic fundoplication (LFN), laparoscopic hepaticoduodenostomy (LHD), and laparoscopic ureteroureterostomy (LUU). The same teams also performed LFN on live pigs. Attendees (3 CSs, 3 STs, and 3 JTs) were administered a questionnaire to rate their CST experience according to five criteria (tissue texture, organ size, operative field, "feel," and anatomic relationships) using a 4-point scale with 0 being the worst response. Scores were averaged per procedure per attendee groups and compared. LFN was also compared between a cadaver and a pig. Results: End-point (1): For LFN, cadaver scores were significantly higher than pig scores for anatomic relationships (P = .0001), operative field (P = .0053), and organ size (P = .0481). End-point (2): TRL and LFN were ranked together as being most realistic, followed by TEE and LUU, then LHD. End-point (3): Anatomic relationships and operative field consistently scored highly for all attendee groups. End-point (4): CSs and STs tended to award higher scores than JTs although differences were not statistically significant. Conclusions: CST is a valuable opportunity for PS trainees to experience highly realistic training in minimally invasive surgery. Pig training was inferior. IRB Number: 2019173.
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- 2021
20. Oncologic safety of Carrel patch hepaticojejunostomy for treating cystic-type choledochal cyst in children based on 20-plus years follow-up
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Junya, Ishii, Go, Miyano, Toshiaki, Takahashi, Takanori, Ochi, Yuichiro, Miyake, Hiroyuki, Koga, Shogo, Seo, Geoffrey J, Lane, Koji, Fukumoto, Atsushi, Arakawa, and Atsuyuki, Yamataka
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Pediatrics, Perinatology and Child Health ,Surgery ,General Medicine - Abstract
During choledochal cyst (CC) excision, the hepaticojejunostomy anastomosis (HJA) can be performed conventionally (CHJA) or with a Carrel patch (CPA). CPA can increase CHD diameter to 10-13 mm, preventing anastomotic stenosis and intrahepatic bile duct (IHBD) stones but may be at risk for malignant transformation.The medical records of 83 cystic-type CC with CHD ≤ 9 mm followed up for at least 20 years were reviewed retrospectively. Available excised CC specimens (70/83) were re-examined blindly for pre-malignant changes. A questionnaire about suturing narrow lumens was conducted.All 83 had pancreaticobiliary maljunction. Group data were similar. Anastomoses were CPA (n = 43) and CHJA (n = 40). Mean diameter for CPA was 11.4 mm (range: 10-13 mm); for CHJA was 7.4 mm (range: 5-9 mm). Mean follow-up was 27.7 years (range: 20-42). Postoperative anastomotic stenoses were less after CPA: 1/43 (2.3%) versus 5/40 (12.5%) (p = 0.10), but CHJA had significantly more postoperative IHBD stones: 0% versus 4/40 (10.0%) (p 0.05). All IHBD stone patients had anastomotic stenosis. Excised specimens showed no pre-malignant cytology. Lumen diameter ≤ 9 mm was considered challenging by 10/10 surgical trainees and ≤ 7 mm by 16/22 pediatric surgeons.CPA appears to be oncologically safe because of the absence of malignant transformation for at least 20 years.
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- 2022
21. Successful engraftment of bladder organoids in de-epithelialized mouse colon
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Kazuto, Suda, Yuka, Matsumoto, Takanori, Ochi, Hiroyuki, Koga, Geoffrey J, Lane, Nobutaka, Hattori, Tetsuya, Nakamura, and Atsuyuki, Yamataka
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Organoids ,Mice ,Urinary Bladder Calculi ,Colon ,Urinary Bladder ,Pediatrics, Perinatology and Child Health ,Animals ,Surgery ,General Medicine ,Urothelium - Abstract
Purpose To engraft bladder organoids (BO) on de-epithelialized mouse colon using an epithelial replacement technique. Methods BO cultured using bladder specimens from enhanced green fluorescent protein (EGFP) transgenic mice were engrafted to replace proximal colon epithelium stripped from an approximately 1cm long target site in syngeneic wild-type recipient mice (n = 9) by exposure to ethylenediaminetetraacetic acid by infusion and flushing with phosphate buffered saline. Target sites were harvested on postoperative days 2, 7, and 28 for hematoxylin-eosin staining and immunofluorescence. Results Histology on postoperative days 7 and 28 showed BO derived EGFP + cells forming multiple layers on the luminal surface of the colon. Immunohistochemistry showed that EGFP + areas were positive for CK5 and CK14, markers for basal and immature subtype urothelium, respectively, but negative for CA2, a marker for colonic epithelium. Ki67 was detected predominantly in the basal parts of EGFP + areas on post-operative day 7 and day 28. Conclusions This is the first report of successful engraftment of BO in de-epithelialized colon with urothelial tissue reconstituted by actively-proliferating cells. This technique could be developed for augmentation cystoplasty to prevent bladder calculi formation and malignant transformation.
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- 2022
22. Native liver survivors of portoenterostomy for biliary atresia with excellent outcome. Redefining 'successful' portoenterostomy
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Koichi Tsuboi, Hiroko Watayo, Takafumi Tsukui, Kazuto Suda, Eri Abe, Takamori Fujimoto, Takanori Ochi, Geoffrey J. Lane, Hiroyuki Koga, and Atsuyuki Yamataka
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Liver ,Biliary Atresia ,Pediatrics, Perinatology and Child Health ,Humans ,Surgery ,Portoenterostomy, Hepatic ,General Medicine ,Aspartate Aminotransferases ,Survivors - Abstract
Purpose: Native liver survivors (NLS) after portoenterostomy (PE) for biliary atresia (BA) with normal biomarkers defined as total bilirubin (T-Bil), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) for liver function (LF), cholinesterase (ChE), platelet count (PC), and absence of portal hypertension (PHT) were reviewed to redefine “successful” PE. Methods: 92 post-PE BA patients were classified as NLS-1: normal biomarkers, PHT (-); NLS-2: at least one abnormal biomarker, PHT (-); NLS-3: normal biomarkers, PHT (+); NLS-4: abnormal biomarkers, PHT (+) and reviewed for a maximum 32 years. Results: As of June 2022, 55/92 (59.8%) had received liver transplants and 37/92 (40.2%) were NLS. NLS patients were classified as excellent outcome (EO): NLS-1 (n=10; 27.0%) or non-EO: NLS-2: (n=8; 21.6%), NLS-3: (n=6; 16.2%), and NLS-4: (n=13; 35.1%). Compared with non-EO, EO had PE earlier (50.5 versus 65 days; not significant; p=0.08), significantly earlier onset of symptoms (13 days versus 32 days; p=0.01) and significantly shorter jaundice-clearance (JC; 34.5 days versus 56.0 days; pConclusions: Incidence of “successful” PE or EO is low and correlated with early onset of symptoms and quicker JC.
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- 2022
23. Performance Evaluation of Popularity-Aware Dynamic Clustering Scheme for Distributed Caching in ICN
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Mikiya Yoshida, Yusuke Ito, Yurino Sato, and Hiroyuki Koga
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- 2022
24. Poster: A Content Popularity Classification-Based Content Search Scheme for CCN
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Yurino Sato and Hiroyuki Koga
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- 2022
25. Changes in postoperative quality of life of pediatric total colonic aganglionosis patients: effect of pull-through technique
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Go Miyano, Keiichi Morita, Koichi Tsuboi, Seitaro Kosaka, Toshiaki Takahashi, Susumu Yamada, Shunsuke Yamada, Takanori Ochi, Shogo Seo, Hiroyuki Koga, Tsubasa Takahashi, Koji Fukumoto, Naoto Urushihara, Tadashi Hatakeyama, Tadaharu Okazaki, Toshihiro Yanai, Geoffrey J. Lane, and Atsuyuki Yamataka
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Adult ,Treatment Outcome ,Postoperative Complications ,Adolescent ,Enterocolitis ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Humans ,Surgery ,General Medicine ,Hirschsprung Disease ,Child ,Retrospective Studies - Abstract
To assess mid-/long-term quality of life (QOL) of total colonic aganglionosis (TCA) patients.Modified pre-existing QOL assessment tools for general lifestyle (GL), bowel function (BF), and mental health (MH) were administered to postoperative TCA patients from five institutions, who were at least 7 years old to compare Duhamel (with pouch) and Swenson/Soave (without pouch) techniques between children (Ch 7-12 years old), teenagers (Tn 13-19), and adults (Ad 20 and over). For MH, caregivers were also interviewed, but separately. Maximum scores were 12 for GL/MH and 18 for BF.There were 32 subjects. GL and BF scores increased significantly from Ch (GL 4.8 ± 2.5, BF: 11.3 ± 4.6) to Tn (GL 7.8 ± 2.6, BF 16.2 ± 3.0); scores for MH did not change significantly. Mean caregiver MH scores were significantly lower than mean subject MH scores for all age groups (subject scores: 10.1, 10.7, 10.7 versus caregiver scores: 6.8, 7.8, 8.1 for Ch, Tn, Ad, respectively). PT technique/presence of a pouch did not influence the incidence of enterocolitis or QOL scores.MH responses showed subjects felt better than caregivers believed. This discrepancy could cause conflict despite steadily improving GL/BF. QOL was unaffected by PT technique/presence of a pouch.
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- 2022
26. Pediatric Pancreatic Endocrine Tumor Presenting as Acute Pancreatitis: A Case Report
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Shigetaka Fukuda, Mitsuyoshi Suzuki, Kei Minowa, Hiroyuki Koga, Atsuyuki Yamataka, and Toshiaki Shimizu
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Pediatrics, Perinatology and Child Health - Abstract
Pancreatic neuroendocrine tumors (PNETs) are relatively rare, especially in the pediatric age group. This report describes a pediatric case of acute pancreatitis secondary to stenosis of the main pancreatic duct due to a PNET. The patient was a boy, thirteen and a half years old, who presented with persistent low-grade fever, nausea, and abdominal pain. He was diagnosed with acute pancreatitis based on the elevation of serum pancreatic enzyme levels and abdominal ultrasonography findings of enlargement of the pancreas and dilatation of the main pancreatic duct. Abdominal contrast-enhanced computed tomography (CT) showed a 5.5 mm, contrast-enhanced mass in the head of the pancreas. His symptoms resolved with conservative treatment, although the pancreatic tumor grew slowly. At fifteen years and four months, since the tumor had enlarged to 8.0 mm, the patient underwent pancreaticoduodenectomy for therapeutic and diagnostic purposes. Based on the pathological evaluation, he was diagnosed with PNET (grade: G1). The patient has been free of tumor recurrence for 10 years and requires no additional therapy. In this report, the clinical characteristics of PNETs are also discussed, comparing the clinical features of adult-onset and pediatric-onset cases that initially present as acute pancreatitis.
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- 2023
27. Identification of the unique molecular framework of heterophylly in the amphibious plantCallitriche palustrisL
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Yumiko Takebayashi, Mikiko Kojima, Hiroyuki Koga, Hirokazu Tsukaya, and Hitoshi Sakakibara
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AcademicSubjects/SCI01280 ,Gene Expression ,Plant Science ,Biology ,In Brief ,Transcriptome ,chemistry.chemical_compound ,Plant Growth Regulators ,Aquatic plant ,Botany ,Gene expression ,Callitriche palustris ,Abscisic acid ,Research Articles ,Leaf formation ,AcademicSubjects/SCI01270 ,AcademicSubjects/SCI02288 ,AcademicSubjects/SCI02287 ,AcademicSubjects/SCI02286 ,fungi ,food and beverages ,Plantaginaceae ,Cell Biology ,Ethylenes ,Plants ,biology.organism_classification ,Gibberellins ,Plant Leaves ,chemistry ,Identification (biology) ,Gibberellin ,Abscisic Acid - Abstract
Heterophylly is the development of different leaf forms in a single plant depending on the environmental conditions. It is often observed in amphibious aquatic plants that can grow under both aerial and submerged conditions. Although heterophylly is well recognized in aquatic plants, the associated developmental mechanisms and the molecular basis remain unclear. To clarify these underlying developmental and molecular mechanisms, we analyzed heterophyllous leaf formation in an aquatic plant, Callitriche palustris. Morphological analyses revealed extensive cell elongation and the rearrangement of cortical microtubules in the elongated submerged leaves of C. palustris. Our observations also suggested that gibberellin, ethylene, and abscisic acid all regulate the formation of submerged leaves. However, the perturbation of one or more of the hormones was insufficient to induce the formation of submerged leaves under aerial conditions. Finally, we analyzed gene expression changes during aerial and submerged leaf development and narrowed down the candidate genes controlling heterophylly via transcriptomic comparisons, including a comparison with a closely related terrestrial species. We discovered that the molecular mechanism regulating heterophylly in C. palustris is associated with hormonal changes and diverse transcription factor gene expression profiles, suggesting differences from the corresponding mechanisms in previously investigated amphibious plants., We identified the key gene set and the hormonal control basis for the drastic heterophylly of an aquatic plant, Callitriche palustris.
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- 2021
28. Endoscopic Ultrasound-guided Hepaticogastrostomy in a Seven-year-old Girl
- Author
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Shigeto Ishii, Hiroyuki Koga, Hiroaki Saito, Shogo Seo, Mako Ushio, Sho Takahashi, Yusuke Takasaki, Akinori Suzuki, Koichi Ito, Kazushige Ochiai, Ko Tomishima, Toshio Fujisawa, Atsuyuki Yamataka, Shuichiro Shiina, and Hiroyuki Isayama
- Subjects
Adult ,Biliary Tract Surgical Procedures ,Cholestasis ,Internal Medicine ,Humans ,Drainage ,Female ,Stents ,General Medicine ,Child ,Ultrasonography, Interventional ,Endosonography - Abstract
Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is an effective biliary drainage procedure in adult cases with difficult biliary access. However, there have been no reports on this procedure being used in pediatric cases. We successfully performed EUS-HGS in a pediatric case with a surgically altered anatomy. A standard convex-type echoendoscope and standard devices were used, and there were no device-related complications. The benefit of EUS-HGS for pediatric patients was avoidance of a percutaneous tube, which is difficult to maintain in active children. The accumulation of further cases and performance of a prospective study are warranted to standardize and expand the experience with this procedure.
- Published
- 2022
29. Empirical Study of Low-Latency Network Model with Orchestrator in MEC
- Author
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Katsuyoshi Iida, Hiroyuki Koga, Krittin Intharawijitr, and Katsunori Yamaoka
- Subjects
and experiment ,Mobile edge computing ,Computer Networks and Communications ,business.industry ,Computer science ,Empirical research ,mobile edge computing ,prototype ,Electrical and Electronic Engineering ,Latency (engineering) ,low-latency network ,business ,Software ,Computer network ,Network model - Abstract
The Internet of Things (IoT) with its support for cyber-physical systems (CPS) will provide many latency-sensitive services that require very fast responses from network services. Mobile edge computing (MEC), one of the distributed computing models, is a promising component of the low-latency network architecture. In network architectures with MEC, mobile devices will offload heavy computing tasks to edge servers. There exist numbers of researches about low-latency network architecture with MEC. However, none of the existing researches simultaneously satisfy the followings: (1) guarantee the latency of computing tasks and (2) implement a real system. In this paper, we designed and implemented an MEC based network architecture that guarantees the latency of offloading tasks. More specifically, we first estimate the total latency including computing and communication ones at the centralized node called orchestrator. If the estimated value exceeds the latency requirement, the task will be rejected. We then evaluated its performance in terms of the blocking probability of the tasks. To analyze the results, we compared the performance between obtained from experiments and simulations. Based on the comparisons, we clarified that the computing latency estimation accuracy is a significant factor for this system.
- Published
- 2021
30. Prevalence of anatomical variations in children with congenital lung malformations investigated by video recordings of thoracoscopic lobectomy
- Author
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Soichi Shibuya, Shunsuke Yamada, Ryo Sueyoshi, Hiroyuki Koga, Kenji Suzuki, and Atsuyuki Yamataka
- Published
- 2023
31. Looking beyond the gene network – metabolic and mechanical cell drivers of leaf morphogenesis
- Author
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Hokuto Nakayama, Hiroyuki Koga, Yuchen Long, Olivier Hamant, Ali Ferjani, Tokyo University of Science [Tokyo], National University of Singapore (NUS), Reproduction et développement des plantes (RDP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Tokyo Gakugei University
- Subjects
Plant Leaves ,Plant Cells ,Morphogenesis ,Plant Development ,Gene Regulatory Networks ,Cell Biology ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Plants - Abstract
The above-ground organs in plants display a rich diversity, yet they grow to characteristic sizes and shapes. Organ morphogenesis progresses through a sequence of key events, which are robustly executed spatiotemporally as an emerging property of intrinsic molecular networks while adapting to various environmental cues. This Review focuses on the multiscale control of leaf morphogenesis. Beyond the list of known genetic determinants underlying leaf growth and shape, we focus instead on the emerging novel mechanisms of metabolic and biomechanical regulations that coordinate plant cell growth non-cell-autonomously. This reveals how metabolism and mechanics are not solely passive outcomes of genetic regulation but play instructive roles in leaf morphogenesis. Such an integrative view also extends to fluctuating environmental cues and evolutionary adaptation. This synthesis calls for a more balanced view on morphogenesis, where shapes are considered from the standpoints of geometry, genetics, energy and mechanics, and as emerging properties of the cellular expression of these different properties.
- Published
- 2022
32. Successful salvage urethroplasty with pedicled soft tissue reinforcement for failed hypospadias repair
- Author
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Shogo Seo, Yuichiro Miyake, Masahiro Takeda, Yuta Yazaki, Takanori Ochi, Go Miyano, Hiroyuki Koga, Geoffrey J. Lane, and Atsuyuki Yamataka
- Subjects
nervous system ,genetic structures ,behavioral disciplines and activities ,psychological phenomena and processes - Abstract
Purpose: The high incidence of scarring and vascular compromise after failed hypospadias repair greatly compromises salvage urethroplasty. Pedicled soft tissue reinforcement (STR) is presented for enhancing the potential for success.Methods: The impact of lateral reinforcement of the scarred urethral plate to boost thickness and perfusion at the time of curvature correction (called CHARGE by the authors) and covering the neourethra at the time of urethroplasty (NUC) used as STR during salvage tubularized incised plate urethroplasty performed between 2003 and 2019 were assessed by retrospective review of the medical records of 8 cases of failed hypospadias repair. Results: Types of hypospadias were perineal/penoscrotal (n=7), and mid-shaft (n=1). Indications for salvage surgery included residual penile curvature (n=5), urethral diverticulum >15mm (n=3), urethral dehiscence (n=1), and urethral stricture (n=1). Salvage surgery was single-stage (urethroplasty at the same of curvature correction; n=1) or multi-stage (n=7; two-stage: n=4, three-stage: n=3). All cases had NUC and 4/8 had CHARGE. All salvage repairs were successful with no incidence of postoperative complications after mean follow-up of 3.9 years (range: 1.6-6.4 years) after the last procedure.Conclusion: STR most likely enhanced tissue perfusion/pliability which ensured the success of salvage urethroplasty for failed hypospadias repair.
- Published
- 2022
33. Significant neonatal intraoperative cerebral and renal oxygen desaturation identified with near-infrared spectroscopy
- Author
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Yuichiro Miyake, Shogo Seo, Kumi Kataoka, Takanori Ochi, Go Miyano, Hiroyuki Koga, Geoffrey J. Lane, Kinya Nishimura, Eiichi Inada, and Atsuyuki Yamataka
- Subjects
Oxygen ,Spectroscopy, Near-Infrared ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Brain ,Humans ,Surgery ,Abdominal Cavity ,General Medicine ,Oximetry ,Child ,Kidney ,Monitoring, Physiologic - Abstract
Near-infrared spectroscopy (NIRS) was used to monitor intraoperative regional oxygen saturation (rSONIRS sensors were applied to the forehead and flanks for cerebral rSOMean ages at surgery were N: 5.2 ± 8.2 days, MOp: 2.4 ± 2.9 years, and MMI: 3.8 ± 4.3 years. Despite significantly shorter operative times in N (169 ± 94 min; p 0.0001), PD was significantly worse; PD(C-rSO
- Published
- 2022
34. Minimally Invasive Techniques in Pediatric Urology: Vesicoureteral Reflux Endoscopy
- Author
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Hiroyuki Koga, Hiroshi Murakami, and Atsuyuki Yamataka
- Published
- 2022
35. Simulation Study of Low-Latency Network Model with Orchestrator in MEC
- Author
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Katsunori Yamaoka, Hiroyuki Koga, Krittin Intharawijitr, and Katsuyoshi Iida
- Subjects
Processor sharing ,Mobile edge computing ,Computer Networks and Communications ,business.industry ,Computer science ,processor sharing ,simulation ,mobile edge computing ,Electrical and Electronic Engineering ,Latency (engineering) ,low-latency network ,business ,orchestrator ,Software ,Computer network ,Network model - Abstract
Most of latency-sensitive mobile applications depend on computational resources provided by a cloud computing service. The problem of relying on cloud computing is that, sometimes, the physical locations of cloud servers are distant from mobile users and the communication latency is long. As a result, the concept of distributed cloud service, called mobile edge computing (MEC), is being introduced in the 5G network. However, MEC can reduce only the communication latency. The computing latency in MEC must also be considered to satisfy the required total latency of services. In this research, we study the impact of both latencies in MEC architecture with regard to latency-sensitive services. We also consider a centralized model, in which we use a controller to manage flows between users and mobile edge resources to analyze MEC in a practical architecture. Simulations show that the interval and controller latency trigger some blocking and error in the system. However, the permissive system which relaxes latency constraints and chooses an edge server by the lowest total latency can improve the system performance impressively.
- Published
- 2019
36. Congenital Pulmonary Airway Malformation in Children: Advantages of an Additional Trocar in the Lower Thorax for Pulmonary Lobectomy
- Author
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Ryohei Kuwatsuru, Kazuhiro Suzuki, Geoffrey J. Lane, Yukio Watanabe, Atsuyuki Yamataka, Kinya Nishimura, Hiroyasu Ueno, Shunki Hirayama, Takanori Ochi, Kota Imashimizu, Hiroyuki Koga, and Kenji Suzuki
- Subjects
Thorax ,medicine.medical_specialty ,medicine.medical_treatment ,Axillary lines ,anterior approach ,Pediatrics ,RJ1-570 ,thoracoscopic surgery ,Pulmonary lobectomy ,congenital pulmonary airway malformation ,medicine ,Thoracotomy ,Original Research ,child ,pulmonary lobectomy ,business.industry ,Congenital pulmonary airway malformation ,Perioperative ,medicine.disease ,Surgery ,Dissection ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Intercostal space ,posterior approach ,business - Abstract
Aim: To present the use of an additional trocar (AT) in the lower thorax during thoracoscopic pulmonary lobectomy (TPL) in children with congenital pulmonary airway malformation.Methods: For a lower lobe TPL (LL), an AT is inserted in the 10th intercostal space (IS) in the posterior axillary line after trocars for a 5-mm 30° scope, and the surgeon's left and right hands are inserted conventionally in the 6th, 4th, and 8th IS in the anterior axillary line, respectively. For an upper lobe TPL (UL), the AT is inserted in the 9th IS, and trocars are inserted in the 5th, 3rd, and 7th IS, respectively. By switching between trocars (6th↔8th for the scope, 4th↔6th for the left hand, and 8th↔10th for the right hand during LL and 5th↔7th, 3rd↔5th, and 7th↔9th during UL, respectively), vital anatomic landmarks (pulmonary veins, bronchi, and feeding arteries) can be viewed posteriorly. The value of AT was assessed from blood loss, operative time, duration of chest tube insertion, requirement for post-operative analgesia, and incidence of perioperative complications.Results: On comparing AT+ (n = 28) and AT– (n = 27), mean intraoperative blood loss (5.6 vs. 13.0 ml), operative time (3.9 vs. 5.1 h), and duration of chest tube insertion (2.2 vs. 3.4 days) were significantly decreased with AT (p < 0.05, respectively). Differences in post-operative analgesia were not significant. There were three complications requiring conversion to open/mini-thoracotomy: AT– (n = 2; bleeding), AT+: (n = 1; erroneous stapling).Conclusions: An AT and switching facilitated posterior dissection during TPL in children with congenital pulmonary airway malformation enhancing safety and efficiency.
- Published
- 2021
37. Forty-Year Experience Alleviating Postoperative Hirschsprung-Associated Enterocolitis by Complete Full-Thickness Posterior Rectal Cuff Excision. The Anorectal Line Eliminates Problematic Anastomoses
- Author
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Yusuke Shigeta, Masahiro Takeda, Masahiko Urao, Go Miyano, Tadaharu Okazaki, Nana Nakazawa-Tanaka, Takanori Ochi, Hiroyuki Koga, Takashi Doi, Geoffrey J. Lane, Tsubasa Takahashi, and Atsuyuki Yamataka
- Subjects
Hirschsprung associated enterocolitis ,medicine.medical_specialty ,business.industry ,Enterocolitis ,Rectum ,Infant ,Anastomosis ,medicine.disease ,Surgery ,Postoperative Complications ,Treatment Outcome ,Cuff ,medicine ,Humans ,Full thickness ,Hirschsprung Disease ,Line (text file) ,business ,Child ,Hirschsprung's disease ,Retrospective Studies - Abstract
Introduction: A modified pull-through (PT) distinguished by complete full-thickness removal of the posterior rectal cuff, initially developed as an open procedure in 1980, has been performed with l...
- Published
- 2021
38. A maneuver for successful anastomosis without haptic feedback during da Vinci robotic surgery: Hepaticojejunostomy for choledochal cyst in children
- Author
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Takanori Ochi, Hiroyuki Koga, Go Miyano, Hiroshi Murakami, Hiroki Nakamura, Atsuyuki Yamataka, and Geoffrey J. Lane
- Subjects
medicine.medical_specialty ,business.industry ,Anastomosis ,medicine.disease ,Da Vinci Surgical System ,Surgery ,medicine.anatomical_structure ,Common hepatic duct ,Cardiothoracic surgery ,Pediatric surgery ,medicine ,Robotic surgery ,Choledochal cysts ,business ,Abdominal surgery - Abstract
In children with choledochal cyst (CC), the diameter at the hepaticojejunostomy anastomosis (HJA) is usually less than 10 mm. The da Vinci surgical system (dV) has been used successfully for treating CC in children, but lack of haptic feedback can hinder suturing at times. We describe a simple maneuver that allows dV-assisted HJA (dV-HJA) to be completed successfully without haptic feedback. The maneuver involves placing the final three 5/0 or 6/0 absorbable sutures between the incision in the Roux-loop jejunum and the common hepatic duct for closing the anterior wall, without tying any of them. Only after all sutures have been placed, they are tied. The tie should never be performed before all the sutures have been placed, because if any one of the last 3 sutures is tied prior the others being placed, the surgeon will not be able to “see” where to place the subsequent suture. Even the smallest HJA should be possible to be completed confidently using this maneuver. We treated 13 consecutive children with CC during a recent 3-year period using this maneuver during dV-HJA. Mean age at surgery: 5.8 years (range 1.8–11.2 years); mean weight at surgery: 18.5 kg (range 9.4–35.6 kg). Mean HJA diameter was 7.9 ± 3.2 mm (range 4–15 mm). All HJA were performed successfully with no reports of anastomotic leakage or anastomotic stenosis after a mean follow-up of 22 months (range 4–34 months). The described maneuver provides the surgeon with visual cues to complete suturing successfully and confidently when haptic feedback is lacking.
- Published
- 2021
39. Comparison of 2K and 4K imaging systems for laparoscopic repair of choledochal cyst in children
- Author
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Shogo Seo, Geoffrey J. Lane, Yuichiro Miyake, Takanori Ochi, Hiroyuki Koga, and Atsuyuki Yamataka
- Subjects
medicine.medical_specialty ,business.industry ,Anastomosis, Surgical ,Pediatric Surgeon ,Anastomosis, Roux-en-Y ,General Medicine ,Anastomosis ,medicine.disease ,Surgery ,Biliary Tract Surgical Procedures ,Treatment Outcome ,Choledochal Cyst ,Pediatrics, Perinatology and Child Health ,medicine ,Operative time ,Humans ,Choledochal cysts ,Laparoscopy ,Single institution ,business ,Child ,Retrospective Studies - Abstract
The safety and success of laparoscopic choledochal cyst surgery (LapCC) depends upon two critical elements during the hepaticojejunostomy anastomosis (HJA). These may be termed the Difficulty of Differentiation (DOD) and the Difficulty of Suturing (DOS). The type of imaging system (2 or 4 K) used may influence either of these. We compared outcomes of LapCC using 2 or 4 K imaging systems.LapCC were performed at a single institution by the same team using a 2 K system (2009-2018; n = 26) and a 4 K system (2018-2019; n = 11) were compared. 4 K cases were chosen to match 2 K cases to minimize bias. Five independent senior pediatric surgeons scored DOD and DOS blindly from intraoperative video recordings of LapCC using a subjective 5-point scale (5: impossible, 4: difficult, 3: tedious, 2: slow, and 1: easy) and rated their over all impression as +1 if 4 K was better, 0 if they were the same, and -1 if 4 K was worse. Total HJA anastomosis time (TAT) and TAT/suture were also calculated.LapCC was performed in 37 age/weight/HJA diameter matched children. Scores for DOD (p0.001) were lower with 4 K with less variance, although there was no difference in DOS (p = 0.08). Operative time (p = 0.03) and duration of hospitalization (p 0.001) were significantly shorter with 4 K. 4 K was rated +1 unanimously. There was no difference in TAT (p = 0.17) and TAT/suture (p = 0.22). There was one HJA leak with 2 K (3.8%) and no complications with 4 K.Improved resolution with 4 K improved the progress of surgery as reflected by shorter operative time and duration of hospitalization, enhancing the performance of LapCC in children.III.
- Published
- 2021
40. Callitriche as a potential model system for evolutionary studies on the dorsiventral distribution of stomata
- Author
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Yuki Doll, Hirokazu Tsukaya, and Hiroyuki Koga
- Subjects
business.industry ,Short Communication ,fungi ,Distribution (economics) ,Model system ,Plant Science ,Biology ,biology.organism_classification ,Callitriche ,Genus ,Aquatic plant ,Botany ,Plant species ,Evolutionary developmental biology ,Adaptation ,business - Abstract
Controlling the distribution of stomata is crucial for the adaptation of plants to new, or changing environments. While many plant species produce stomata predominantly on the abaxial leaf surface (hypostomy), some produce stomata on both surfaces (amphistomy), and the remaining few produce them only on the adaxial surface (hyperstomy). Various selective pressures have driven the evolution of these three modes of stomatal distribution. Despite recent advances in our understanding of stomatal development and dorsiventral leaf polarity, the genetic basis for the evolution of different stomatal distributions is still unclear. Here, we propose the genus Callitriche as a new model system to investigate patterns in the evolution of stomatal distribution. Callitriche comprises species with diverse lifestyles, including terrestrial, amphibious, and obligately aquatic plants. We found that species in this genus cover all three modes of dorsiventral stomatal distribution, making it a desirable model for comparative and evolutionary analyses on distribution modes. We further characterized the genetic basis of the different distribution modes, focusing on the stomatal key transcription factor SPEECHLESS. Future research using the promising model system Callitriche would open a new direction for evolutionary developmental biology studies on stomata.
- Published
- 2021
41. Recovery of bowel function after transperitoneal or retroperitoneal laparoscopic pyeloplasty. A multi-center study
- Author
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Go Miyano, Toshihiro Yanai, Atsushi Hamano, Kazuto Suda, Shogo Seo, Atsuyuki Yamataka, Kensuke Ohashi, Geoffrey J. Lane, Takanori Ochi, Hiroyuki Koga, Minoru Tada, and Takayuki Masuko
- Subjects
Pyeloplasty ,medicine.medical_specialty ,Ileus ,Nausea ,medicine.medical_treatment ,Urology ,Nephrectomy ,medicine ,Intubation ,Humans ,Retroperitoneal Space ,Laparoscopy ,Child ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,General Medicine ,Perioperative ,medicine.disease ,Pediatrics, Perinatology and Child Health ,Vomiting ,Defecation ,Surgery ,medicine.symptom ,Ureter ,business - Abstract
To document the recovery of bowel function (BF) in children after transperitoneal (TP) or retroperitoneal (RP) laparoscopic pyeloplasty. Data were obtained retrospectively from four centers between 2008 and 2019 for TP (n = 51) and RP (n = 58). Each surgeon chose which technique to perform. Subject demographics were not significantly different. Differences in operative times were not significant (RP: 241 min versus TP: 225 min). Mean duration/requirement for postoperative epidural/intravenous analgesia were not significantly different (TP: 1.4 days versus RP: 1.3 days) and (TP: 66.7% versus RP: 67.2%), respectively. Postoperative nasogastric (NG) intubation was more common in RP (TP: 19.6% versus RP: 44.8%; p
- Published
- 2021
42. Defined serum-free culture of human infant small intestinal organoids with predetermined doses of Wnt3a and R-spondin1 from surgical specimens
- Author
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Takanori Ochi, Atsuyuki Yamataka, Hiroyuki Koga, Go Miyano, Mirei Takahashi, Kazuto Suda, Hideaki Nakajima, Yuichiro Miyake, Tadaharu Okazaki, Shiho Yoshida, Shogo Seo, Takafumi Mikami, Yuka Matsumoto, Nobutaka Hattori, and Tetsuya Nakamura
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Cellular differentiation ,Stem Cells ,Infant ,Cell Differentiation ,General Medicine ,Intestines ,Organoids ,Chemically defined medium ,Real-time polymerase chain reaction ,Serum free ,Wnt3A Protein ,Pediatrics, Perinatology and Child Health ,Intestine, Small ,medicine ,Organoid ,Humans ,Surgery ,Stem cell ,RSPO1 ,business ,WNT3A - Abstract
Refinement of organoid technology is important for studying physiology and disease of the intestine. We aimed to optimize defined serum-free conditions for human infant small intestinal (SI) organoid culture with predetermined doses of Wnt3a and Rspo1 from surgical specimens. We further assessed whether intestinal specimens could be stored before use as a source of organoids. Different doses of Wnt3a and Rspo1 in a serum-free medium were tested to establish a condition in which surgically resected SI cells grew as organoids over multiple passages. The expression of marker genes for stem and differentiated cells was assessed by quantitative polymerase chain reaction. We also investigated the organoid-forming efficiency of cells in degenerating intestines stored at 4 °C for various intervals post-resection. We determined the doses of Wnt3a and Rspo1 required for the continuous growth of infant SI organoids with multi-differentiation potential. We revealed that, despite the time-dependent loss of stem cells, tissues stored for up to 2 days preserved cells capable of generating amplifiable organoids. SI cells can be grown as organoids under defined conditions. This could provide a reproducible and customizable method of using surgical specimens for the study of intestinal maturation and their relevance to pediatric diseases.
- Published
- 2021
43. Perforation in pediatric non-complicated appendicitis treated by antibiotics: the real incidence
- Author
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Go Miyano, Ryohei Kuwatsuru, Shiho Yoshida, Takanori Ochi, Seitaro Kosaka, Kazuhiro Suzuki, Geoffrey J. Lane, Atsuyuki Yamataka, Hiroyuki Koga, Takafumi Mikami, Ryo Sueyoshi, Keisuke Jimbo, Tadaharu Okazaki, Toshiaki Shimizu, Masahiko Urao, and Toshihiro Yanai
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Antibiotics ,Perforation (oil well) ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Pediatric surgery ,medicine ,Appendectomy ,Humans ,Child ,Retrospective Studies ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,General Medicine ,Complicated appendicitis ,Appendicitis ,Anti-Bacterial Agents ,Child, Preschool ,Abdominal ultrasonography ,Pediatrics, Perinatology and Child Health ,Acute appendicitis ,Female ,030211 gastroenterology & hepatology ,Surgery ,Radiology ,Emergencies ,Triage ,Tomography, X-Ray Computed ,business ,Complication - Abstract
The incidence of perforation during antibiotic therapy (AT) of children triaged as non-complicated acute appendicitis (NC-Ap) was investigated. Abdominal ultrasonography (US) and/or computed tomography (CT) scans from cases of perforation identified at appendectomy for failed AT were reassessed blindly by a panel of board-certified specialists for any evidence of pre-AT morbidity suggestive of perforation. Of 521 cases triaged as NC-Ap, symptoms resolved with AT in 452 cases (86.8%). All 69/521 (13.2%) cases with persistent symptoms had urgent appendectomy, and 12/521 (2.3%) were found to have perforated. Blind reassessment of US and/or CT scans from these cases identified seven with evidence of perforation when they were triaged as NC-Ap. Thus, the actual incidence of perforation during AT for NC-Ap was actually 12–7 = 5/521 (0.95%). Perforation is generally believed to be a complication of AT, but inappropriate triaging of cases for AT can bias results by artificially inflating the number of perforations, in this study, by more than double. We are the first to assess the unbiased incidence of perforation during AT for NC-Ap, by reassessing pre-AT US and/or CT scans. The incidence of perforation during AT is actually negligible.
- Published
- 2019
44. Everting the Jejunal Mucosa Ensures a Secure Hepaticojejunostomy Anastomosis During Laparoscopic Repair of Choledochal Cyst in Children
- Author
-
Geoffrey J. Lane, Hiroshi Murakami, Atsuyuki Yamataka, Takanori Ochi, Hiroyuki Koga, and Go Miyano
- Subjects
Male ,Laparoscopic surgery ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Jejunostomy ,Anastomotic Leak ,Anastomosis ,Surgical methods ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Choledochal cysts ,Intestinal Mucosa ,Child ,Jejunal mucosa ,business.industry ,Anastomosis, Surgical ,Suture Techniques ,Infant ,Anastomosis, Roux-en-Y ,medicine.disease ,Roux-en-Y anastomosis ,Surgery ,Biliary Tract Surgical Procedures ,Child, Preschool ,Choledochal Cyst ,030220 oncology & carcinogenesis ,Female ,Laparoscopy ,030211 gastroenterology & hepatology ,business - Abstract
Aim: In children, the diameter at the hepaticojejunostomy anastomosis (HJA) can range from 10 mm to less than 5 mm, irrespective of the type of choledochal cyst (CC). We developed a maneuv...
- Published
- 2019
45. Modified retroperitoneal laparoscopic dismembered pyeloplasty for children
- Author
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Takanori Ochi, Hiroyuki Koga, Yuta Yazaki, Geoffrey J. Lane, Manabu Okawada, Souichi Shibuya, Go Miyano, and Atsuyuki Yamataka
- Subjects
medicine.medical_specialty ,Pyeloplasty ,business.industry ,medicine.medical_treatment ,Anastomosis ,Surgery ,Ureter ,medicine.anatomical_structure ,Cardiothoracic surgery ,medicine ,Retroperitoneal space ,business ,Renal pelvis ,Pelvis ,Abdominal surgery - Abstract
We describe our modified retroperitoneal laparoscopic pyeloplasty (MRLP) and assess the incidence of anastomotic stricture and torsion of the ureter in the mid-term. We reviewed 12 patients with ureteropelvic junction obstruction (UPJO) we treated with MRLP between 2013 and 2018. MRLP involves: identifying the lowest point of the renal pelvis and the lateral aspect of the ureter to ensure correct orientation of the anastomosis; placing the first suture between the lower edge of the incised pelvis and the distal end of the spatulated ureter to avoid crushing tissue that will be anastomosed; and complete excision of the narrow segment. All MRLP were completed successfully without conversion. UPJO was resolved completely, both clinically and radiologically, in all cases. Mean age at surgery was 6.8 years (range: 1.7–8.8 years); mean operative time was 212.1 min (range: 170–333 min); mean estimated blood loss was 4.2 mL (range: 2–8 mL); mean follow-up was 36.7 months (range: 6–65 months); mean post-operative differential renal function on the affected side was 53.1 ± 13.7% (range: 37.0–87.2%), increased from 44.9 ± 16.0% (range: 27.0–84.3%), pre-operatively (p = 0.02). All remain completely cured after mean follow-up of 36.7 ± 19.7 months (range: 6–65). Our MRLP is safe and effective despite limited retroperitoneal space.
- Published
- 2019
46. Hash-Based Cache Distribution and Search Schemes in Content-Centric Networking
- Author
-
Yuusuke Ito, Yurino Sato, and Hiroyuki Koga
- Subjects
Distribution (number theory) ,Artificial Intelligence ,Hardware and Architecture ,business.industry ,Computer science ,Hash function ,Content centric networking ,Computer Vision and Pattern Recognition ,Cache ,Electrical and Electronic Engineering ,business ,Software ,Computer network - Published
- 2019
47. TCP Using Adaptive FEC to Improve Throughput Performance in High-Latency Environments
- Author
-
Yurino Sato, Takeshi Ikenaga, and Hiroyuki Koga
- Subjects
Computer Networks and Communications ,Computer science ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,redundancy control ,congestion control ,Network congestion ,interleave control ,Electrical and Electronic Engineering ,Latency (engineering) ,business ,TCP ,Software ,Computer network ,FEC - Abstract
Packet losses significantly degrade TCP performance in high-latency environments. This is because TCP needs at least one round-trip time (RTT) to recover lost packets. The recovery time will grow longer, especially in high-latency environments. TCP keeps transmission rate low while lost packets are recovered, thereby degrading throughput. To prevent this performance degradation, the number of retransmissions must be kept as low as possible. Therefore, we propose a scheme to apply a technology called “forward error correction” (FEC) to the entire TCP operation in order to improve throughput. Since simply applying FEC might not work effectively, three function, namely, controlling redundancy level and transmission rate, suppressing the return of duplicate ACKs, interleaving redundant packets, were devised. The effectiveness of the proposed scheme was demonstrated by simulation evaluations in high-latency environments.
- Published
- 2019
48. Multicenter, retrospective, comparative study of laparoscopic and open Kasai portoenterostomy in children with biliary atresia from Japanese high-volume centers
- Author
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Yasuhiko Sugawara, Hideyuki Sasaki, Hiroshi Kawashima, Hirotoshi Yamamoto, Hiroo Uchida, Atsuyuki Yamataka, Tetsuya Ishimaru, Taizo Hibi, Chiyoe Shirota, Yutaka Kanamori, Masaki Nio, Masato Shinkai, Naoki Shimojima, Hirofumi Tomita, Naruhiko Murase, Hiroyuki Koga, Akinari Hinoki, and Kazunori Tahara
- Subjects
Male ,Kasai ,medicine.medical_specialty ,Multivariate analysis ,Portoenterostomy, Hepatic ,03 medical and health sciences ,0302 clinical medicine ,Biliary atresia ,Humans ,Medicine ,Propensity Score ,Laparoscopy ,Survival rate ,Retrospective Studies ,Prognostic factor ,Hepatology ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Infant ,Perioperative ,Jaundice ,Portoenterostomy ,Prognosis ,medicine.disease ,Survival Analysis ,Multicenter study ,Surgery ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Hospitals, High-Volume - Abstract
Background: Multicenter study was undertaken to analyze the results of laparoscopic and open Kasai portoenterostomy. Methods: Subjects were infants with type III biliary atresia who underwent open operation (n = 106) or laparoscopic operation (n = 21) between January 2012 and December 2015. Clinical data were compared between open and laparoscopic operations (2016‐0534). Propensity score matching was performed to reduce the effect of treatment selection bias. Multivariate analyses were used to estimate the effect of the surgical approach on the jaundice clearance rate and the native liver survival rate. Results: The postoperative jaundice clearance rate and the 1‐year native liver survival rate were not significantly different between open and laparoscopic operations. Rates of cholangitis and major complications of laparoscopic operation were comparable to those of open operation. Blood loss, time to resume oral intake, time to drain removal, and duration of analgesic usage of laparoscopic operation were significantly superior to those of open operation. Similar results were observed when analysis was adjusted based on propensity score. Multivariate analyses demonstrated that only age at operation was a poor prognostic factor. Conclusion: Laparoscopic Kasai portoenterostomy was associated with several favorable perioperative outcomes compared with open Kasai portoenterostomy. The difference of surgical approach was not a significant independent predictor., ファイル公開:2020-01-24
- Published
- 2019
49. A comparison of laparoscopic redo fundoplications for failed toupet and nissen fundoplications in children
- Author
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Hiroyuki Koga, Koji Fukumoto, Takashi Doi, Hiromu Miyake, Masakatsu Kaneshiro, Go Miyano, Geoffrey J. Lane, Atsuyuki Yamataka, Naoto Urushihara, Mariko Koyama, Manabu Okawada, Masaya Yamoto, Keiichi Morita, and Hiroshi Nouso
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,030232 urology & nephrology ,lcsh:RJ1-570 ,lcsh:Surgery ,Adhesion (medicine) ,lcsh:Pediatrics ,lcsh:RD1-811 ,Dehiscence ,medicine.disease ,Nissen fundoplication ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Pediatrics, Perinatology and Child Health ,Sliding hernia ,Medicine ,Original Article ,Toupet fundoplication ,business ,redo fundoplication - Abstract
Purpose: We compared laparoscopic redo fundoplications performed for failed laparoscopic Toupet fundoplication (LTF) and failed laparoscopic Nissen fundoplications (LNFs). Methods: Redo LTF (R-LTF; n = 4) and redo LNF (R-LNF; n = 6) performed between 2007 and 2014 were assessed retrospectively for severity of intraperitoneal adhesions on a scale of 0–3, identification/preservation of the anterior/posterior/hepatic branches of the vagus nerve (VN), complications, and outcome. Results: Redos were performed after a mean of 34 months in R-LTF and 32 months in R-LNF (P = ns) indicated for sliding hernia (n = 3; 2 with partial wrap dehiscence) and partial wrap dehiscence (n = 1) in R-LTF and sliding hernia (n = 6; 4 with partial wrap dehiscence) in R-LNF. The mean adhesion severity score was 1.5 in R-LTF and 2.5 in R-LNF (P < 0.05). The mean number of VN branches identified/preserved was 2.0 in R-LTF and 0.8 in R-LNF (P < 0.05). Mean operative times and mean blood loss were similar. Intraoperative complications were accidental local trauma (n = 1 in R-LTF and n = 3 in R-LNF, one requiring conversion to open repair) (P = ns). Gastric outlet obstruction developed in two R-LNF cases; both were managed conservatively. There have been no further recurrences to date. Conclusion: Although our series is small, adhesions were less, and identification/preservation of VN was easier during R-LTF.
- Published
- 2019
50. Fact or myth? The long shared common wall between the fistula and the urethra in male anorectal malformation with urethral bulbar fistula
- Author
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Philip K. Frykman, Go Miyano, Geoffrey J. Lane, Takanori Ochi, Hiroyuki Koga, Atsuyuki Yamataka, Hiroshi Murakami, and Stephanie Chen
- Subjects
Male ,Prostatic Diseases ,medicine.medical_specialty ,Urinary Fistula ,Fistula ,Rectourethral fistula ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Urethral Diseases ,Pediatric surgery ,medicine ,Humans ,Rectal Fistula ,Retrospective Studies ,business.industry ,General Medicine ,medicine.disease ,Anorectal Malformations ,Surgery ,Urethra ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,030211 gastroenterology & hepatology ,business ,Prostatic fistula - Abstract
It has long been considered surgical dogma that the length of the shared common wall (CW) between a fistula and the urethra in males with anorectal malformation (ARM) and rectourethral bulbar fistula (RUBF) is considerably longer than in males with ARM and rectourethral prostatic fistula (RUPF). This belief has led surgeons who perform laparoscopic-assisted anorectoplasty (LAARP) for RUPF to avoid LAARP for RUBF for risk of potential injury to the urethra or incomplete removal of the fistula. In this study, we compared CW between RUBF and RUPF using distal colostography (DCG) and direct intraoperative measurements. DCG of rectourethral fistula patients (n = 63; RUBF: n = 44; RUPF: n = 19) were used to measure CW retrospectively. Results were expressed as a ratio of the height of L4; i.e., CW:L4. If less than 0.7, the CW was classified as being “short”; if 0.71–1.4, as being “medium”; and if greater than 1.41, as being “long”. CW that could not be measured was classified as indeterminate. 24 of these patients also had CW measured intraoperatively during LAARP as previously described. The results obtained using both techniques were also compared. Surprisingly, CW:L4 in RUBF patients was short in 47.7%, medium in 27.3%, long in 20.5%, and indeterminate in 4.5% on DCG, equivalent to mean lengths of 7 mm, 8.5 mm, and 10.3 mm obtained using direct intraoperative measurement for short, medium, and long CW:L4 categories, respectively. CW:L4 in RUPF was short in 73.6%, medium in 10.5%, and long in 5.2% on DCG, while mean intraoperative measurements were 5 mm, 7 mm, and 10 mm, respectively. Differences in CW measured intraoperatively were not significantly different between RUBF and RUPF (p = NS). From our findings, 47.7% of CWs in RUBF were short using two independent methods, with only 20.5% being long. Thus, LAARP should be considered actively for treating selected RUBF cases and not be excluded on the basis of CW length.
- Published
- 2018
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