Search

Mastocytosis is a heterogeneous disease with an increased number and activation of mast cells. Subtypes range from benign to rare aggressive forms, and the disease may affect people of all ages. The pathogenesis involves mutations in the KIT gene in both children and adult patients. Estimated prevalence is one per 10,000, but the disease is very likely underdiagnosed. The diagnosis may be challenging and patients may present to several medical specialties. This article presents an overview of clinical signs and symptoms as well as a diagnostic algorithm and treatment options of mastocytosis.

Objective Increased osteoprotegerin (OPG) levels are associated with increased cardiovascular risk and decreased bone resorption. Pioglitazone treatment reduces the inflammatory state but may decrease bone mineral density. OPG levels during pioglitazone treatment have not previously been evaluated in polycystic ovary syndrome (PCOS). Research design and methods Plasma OPG levels were measured in 30 PCOS patients before and after randomized treatment with 30 mg pioglitazone/placebo for 16 weeks. Fourteen age and BMI matched healthy women were included as controls. Clinical and hormonal evaluations and whole body DXA-scans were performed in all participants. Results OPG levels were comparable in PCOS patients [12.0 (10.5 - 14.6) ng/ml] and controls [12.9 (11.7 - 14.9) ng/ml]. In PCOS patients (n=30), OPG levels were positively associated with testosterone (r= 0.43), prolactin (r= 0.47), ICTP (r= 0.43), and hip BMD, whereas inverse associations were found between OPG levels and triglyceride (r= -0.49) and FFA levels during euglycemic clamps (r= -0.38), all p

Den åbne teknologi bag Internettet giver helt nye muligheder for både små og store trafikselskaber. Hjemmesidernes tilbud om information og service giver de første eksempler på bedre overblik og hurtig søgning. Interaktive kort og køreplaner, brevkasser, kortsalg og trafikinformation gør det lettere at være kunde. På samme måde kan vi både samle og sprede interne informationer i planlægningen og styringen af trafikken. Koordinere oplysninger, som i dag ligger adskilt i lukkede systemer. Spare tid og sikre overblik og løbende opdatering. Vi kan nå helt ud til chaufføren bag rattet, til kunden på gaden og hjem til VIP-kunden, test-kunden og den handicappede, der med lidt "automatisk særforplejning" får nye muligheder for at finde vej med kollektiv trafik. På Internettet er alle lige mobile. Den udfordring kan vi bruge til at nedbryde andre grænser., Proceedings from the Annual Transport Conference at Aalborg University, Vol. 5 No. 1 (1998): Proceedings from the Annual Transport Conference at Aalborg University

The study is focused on the Old Norse "contemporary sagas" (texts composed with a short time distance from the events of the twelfth and thirteenth centuries that are recorded in them) and some of the bishops' sagas as images of the thirteenth- and fourteenth-century Icelanders' identity and their relationship to other lands, especially Norway. It aims at analysing the roles and meanings of various identity bearers portrayed in these sources - chieftains, royal representatives, ecclesiastical dignitaries, and saintly bishops. The approach to the sources is based on an analysis of how recent historical events were transformed into a narrative discourse, in which they were connected to the more distant past that formed the medieval Icelandic society's cultural memory. That way, these events themselves became a part of this society's cultural memory, and the given historical knowledge was endowed with specific meanings, which were not inherently present in the knowledge itself, but were based on its contextualization. The study shows how the narrativization of the recent events and their integration into the cultural memory creates a meaningful relationship between the past and the present. The objective of the study is to show how the narrative sources reflect the society's perception of its recent...