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Personalized medicine is the art of customizing healthcare by leveraging and implementing strategic integration of technology and science. Personalized medicine is built on trust between payers, providers, and patients. This digital identity is the core foundation of personalized healthcare. Privacy and security of digital identity in personalized medicine is a combination of mindful patient information flow and inclusion of ethics, strategy, and technology. This chapter describes how to implement a safe and secure digital identity using the concept of designing data-centric compliance or "trust by design."