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1. Additional file 3 of Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial

Author

Erőss, Bálint, Molnár, Zsolt, Szakács, Zsolt, Zádori, Noémi, Szakó, Lajos, Váncsa, Szilárd, Juhász, Márk Félix, Ocskay, Klementina, Vörhendi, Nóra, Márta, Katalin, Szentesi, Andrea, Párniczky, Andrea, Hegyi, Péter J., Kiss, Szabolcs, Földi, Mária, Dembrovszky, Fanni, Kanjo, Anna, Pázmány, Piroska, Varró, András, Csathó, Árpád, Helyes, Zsuzsanna, Péterfi, Zoltán, Czopf, László, Kiss, István, Zemplényi, Antal, Czapári, Dóra, Hegyi, Eszter, Dobszai, Dalma, Miklós, Emőke, Márta, Attila, Tóth, Dominika, Farkas, Richard, Farkas, Nelli, Birkás, Béla, Pintér, Erika, Pethő, Gábor, Zsigmond, Borbála, Sárközi, Andrea, Nagy, Anikó, and Hegyi, Péter

Subjects
Data_FILES
Abstract

Additional file 3.

Published
2020
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2. Additional file 2 of Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial

Author

Erőss, Bálint, Molnár, Zsolt, Szakács, Zsolt, Zádori, Noémi, Szakó, Lajos, Váncsa, Szilárd, Juhász, Márk Félix, Ocskay, Klementina, Vörhendi, Nóra, Márta, Katalin, Szentesi, Andrea, Párniczky, Andrea, Hegyi, Péter J., Kiss, Szabolcs, Földi, Mária, Dembrovszky, Fanni, Kanjo, Anna, Pázmány, Piroska, Varró, András, Csathó, Árpád, Helyes, Zsuzsanna, Péterfi, Zoltán, Czopf, László, Kiss, István, Zemplényi, Antal, Czapári, Dóra, Hegyi, Eszter, Dobszai, Dalma, Miklós, Emőke, Márta, Attila, Tóth, Dominika, Farkas, Richard, Farkas, Nelli, Birkás, Béla, Pintér, Erika, Pethő, Gábor, Zsigmond, Borbála, Sárközi, Andrea, Nagy, Anikó, and Hegyi, Péter

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2020
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3. Additional file 1 of Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial

Author

Erőss, Bálint, Molnár, Zsolt, Szakács, Zsolt, Zádori, Noémi, Szakó, Lajos, Váncsa, Szilárd, Juhász, Márk Félix, Ocskay, Klementina, Vörhendi, Nóra, Márta, Katalin, Szentesi, Andrea, Párniczky, Andrea, Hegyi, Péter J., Kiss, Szabolcs, Földi, Mária, Dembrovszky, Fanni, Kanjo, Anna, Pázmány, Piroska, Varró, András, Csathó, Árpád, Helyes, Zsuzsanna, Péterfi, Zoltán, Czopf, László, Kiss, István, Zemplényi, Antal, Czapári, Dóra, Hegyi, Eszter, Dobszai, Dalma, Miklós, Emőke, Márta, Attila, Tóth, Dominika, Farkas, Richard, Farkas, Nelli, Birkás, Béla, Pintér, Erika, Pethő, Gábor, Zsigmond, Borbála, Sárközi, Andrea, Nagy, Anikó, and Hegyi, Péter

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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4. Additional file 4 of Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial

Author

Erőss, Bálint, Molnár, Zsolt, Szakács, Zsolt, Zádori, Noémi, Szakó, Lajos, Váncsa, Szilárd, Juhász, Márk Félix, Ocskay, Klementina, Vörhendi, Nóra, Márta, Katalin, Szentesi, Andrea, Párniczky, Andrea, Hegyi, Péter J., Kiss, Szabolcs, Földi, Mária, Dembrovszky, Fanni, Kanjo, Anna, Pázmány, Piroska, Varró, András, Csathó, Árpád, Helyes, Zsuzsanna, Péterfi, Zoltán, Czopf, László, Kiss, István, Zemplényi, Antal, Czapári, Dóra, Hegyi, Eszter, Dobszai, Dalma, Miklós, Emőke, Márta, Attila, Tóth, Dominika, Farkas, Richard, Farkas, Nelli, Birkás, Béla, Pintér, Erika, Pethő, Gábor, Zsigmond, Borbála, Sárközi, Andrea, Nagy, Anikó, and Hegyi, Péter

Subjects
Data_FILES
Abstract

Additional file 4.

Published
2020
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5. Genetics and pathophysiology of pancreatitis

Author

Mayerle, Julia, Sendler, Matthias, Hegyi, Eszter, Beyer, Georg, Lerch, Markus M., and Sahin-Tóth, Miklós

Subjects
Protein Folding, Apoptosis, Prognosis, Article, Enzyme Activation, Necrosis, Phenotype, Pancreatitis, Risk Factors, Mutation, Animals, Humans, Genetic Predisposition to Disease, Inflammation Mediators, Pancreas, Peptide Hydrolases, Signal Transduction
Abstract

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease-antiprotease pathway has lent additional support to the notion that pancreatitis is a disease of autodigestion. Clinical and experimental observations have provided compelling evidence that premature intrapancreatic activation of digestive proteases is critical in pancreatitis onset. However, disease course and severity are mostly governed by inflammatory cells that drive local and systemic immune responses. In this article, we review the genetics, cell biology, and immunology of pancreatitis with a focus on protease activation pathways and other early events.

Published
2019

7. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

Author

James R. A. Skipworth, Sebastian Krug, Florence Bühler, Sebastian Gimpfl, Joachim Mössner, Anke Tönjes, Atsushi Masamune, Adrian Saftoiu, Roland H. Pfützer, Marcella Rietschel, Heiko Witt, Felix Stickel, Jens Werner, Peter Kovacs, Nicole Soranzo, Constantin Zimmer, Martin Ziegler, Helmut Laumen, Holger Kirsten, Marco J. Bruno, Joost P.H. Drenth, Markus M. Lerch, Markus M. Nöthen, Claus Hellerbrand, Annette Peters, Philippe Lévy, Jian-Min Chen, Monika Ridinger, Giulia Martina Cavestro, Emmanuelle Masson, Milena Di Leo, Peter Simon, Peter Bugert, Péter Hegyi, Karl Mann, Miklós Sahin-Tóth, Pier Alberto Testoni, Núria Malats, Rene H. M. te Morsche, Konstantin Strauch, Stephen P. Pereira, Josef Frank, Norbert Wodarz, Halina Cichoż-Lach, Jonas Rosendahl, Alexander Schneider, Marcus Hollenbach, Olfert Landt, Markus Löffler, Sergio Pedrazzoli, Volker Keim, Matthias Löhr, Marie Motyka, Sebastian Mueller, Ralph Burkhardt, Antoni Farré, Heidi Griesmann, Falk Kiefer, Giovanni Malerba, Claudia Ruffert, Markus Scholz, Francisco X. Real, Maren Ludwig, Eszter Hegyi, Harald Grallert, Hana Algül, Vinciane Rebours, Eva Rösmann, Frank Ulrich Weiss, Sonja Mohr, Robert Grützmann, Sevastitia Iordache, Michael Soyka, Milan Macek, Peter Lichtner, Patrick Michl, Claude Férec, Giovanni Gambaro, Michael Stumvoll, Katharina Seltsam, Thomas Müller, Grazyna Jurkowska, Ewa Małecka-Panas, Sebastian Beer, Julia Mayerle, Hans-Ulrich Schulz, Lena Werner, Publica, Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, GIULIA MARTINA, Cichoz lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H. M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, PIER ALBERTO, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, Joost, P. H. Drenth, Witt, Heiko, Scholz, Marku, Sahin tóth, Miklós, and Gastroenterology & Hepatology

Subjects
0301 basic medicine, Linkage disequilibrium, medicine.medical_specialty, Settore MED/12 - GASTROENTEROLOGIA, Population, Genome Wide Association Study, Chronic Pancreatitis, Genetic Rearrangement, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Biology, Gastroenterology, chronic pancreatitis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Genetic predisposition, medicine, Allele, education, Genetics, education.field_of_study, medicine.disease, ddc, genetic rearrangement, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, Genome wide association study, Pancreatitis, chronic pancreatiti, Chronic pancreatitis, Genetic rearrangement
Abstract

ObjectiveAlcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.Design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.ResultsWe replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk.ConclusionAn inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.

Published
2018

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