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Objective: High-field intra-operative MRI (iMRI) systems offer excellent imaging quality and are used in a number of centers for resection control and update of the image guidance systems. Although expensive, such a system improves not only the radicality of tumor resections but can improve the safety[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

The combined application of functional magnetic resonance imaging and diffusion tensor based tractography is a reliable technique to localize cortico-subcortical functional systems of the brain. This technical feature will be particularly important for image-guided neurosurgery as well as for intaroperative imaging in future. Due to methodological limitations and external factors (intraoperative brain shift, interstitial brain edema) these MR imaging modalities need to be supplemented by intraoperative electrophysiological mapping techniques. For this purpose, navigated bipolar stimulation is especially appropriate to validate imaging findings and to preserve the functional integrity of cortico-subcortical systems.

Molecular imaging with magnetic resonance imaging (MRI) is currently mainly focussed upon the representation of gene expression, the delineation of cell compartments, cell tracking and the display of extracellular structures. The majority of these methods are still at an experimental stage. The main points of interest in neuroradiology are the differentiation between tumor and non-tumor cells with the aid of oncogene profiles, the tracking of transplanted oligodendrocyte progenitor cells for the determination of the extent of remyelinization in the spinal cord and also the assessment of the therapeutic success in apoplexy using subventricular zone cells. New gadolinium contrast agents have enabled the depiction of β-amyloid plaques in Alzheimer's disease as well as showing the distribution of the endothelial leukocyte receptor ICAM-1 in acute experimental allergic encephalomyelitis (EAE).