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3 results on '"He, Xianran"'

1. Synthesis of Azidosphingosine from D-Galactose or L-Arabinose

Author

Gao, Yangguang, Cao, Zhou, Han, Zhongxiang, Zhang, Qiang, Hu, Jie, Guo, Rui, He, Xianran, Ding, Fei, You, Qingliang, Zhang, Yongmin, Institute for Interdisciplinary Research, Jianghan University, Wuhan, PR China, Jianghan University [Whuan], Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Glycochimie Organique Biologique et Supramoléculaire (GOBS), Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Chimie Moléculaire de Paris Centre (FR 2769), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Key Laboratory of Resource Biology and Biotechnology, and Northwest University, Xi'an

Subjects
GOBS, POLE 3, 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, [CHIM]Chemical Sciences, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences
Published
2019

2. Synthesis of NSAIDs\textendashSe Derivatives as Potent Anticancer Agents

Author

Liu, Lei, Li, Shaolei, LI, Xiaolong, Zhong, Min, Lu, Yin, Jiajie, Yang, Yongmin, Zhang, He, Xianran, Institute for Interdisciplinary Research, Jianghan University, Wuhan, PR China, Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Jianghan University [Whuan], Glycochimie Organique Biologique et Supramoléculaire (GOBS), Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Chimie Moléculaire de Paris Centre (FR 2769), and Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
GOBS, POLE 3, [CHIM]Chemical Sciences
Published
2018

3. Modulating Inhibitors of Transthyretin Fibrillogenesis via Sulfation: Polychlorinated Biphenyl Sulfates as Models1

Author

Grimm, Fabian A., Lehmler, Hans-Joachim, He, Xianran, Robertson, Larry W., and Duffel, Michael W.

Subjects
Molecular Docking Simulation, Amyloid, Structure-Activity Relationship, Molecular Structure, Sulfates, Humans, Prealbumin, Article
Abstract

Small molecules that bind with high affinity to thyroxine (T4) binding sites on transthyretin (TTR) kinetically stabilize the protein's tetrameric structure, thereby efficiently decreasing the rate of tetramer dissociation in TTR related amyloidoses. Current research efforts aim to optimize the amyloid inhibiting properties of known inhibitors, such as derivatives of biphenyls, dibenzofurans and benzooxazoles, by chemical modification. In order to test the hypothesis that sulfate group substituents can improve the efficiencies of such inhibitors, we evaluated the potential of six polychlorinated biphenyl sulfates to inhibit TTR amyloid fibril formation in vitro. In addition, we determined their binding orientations and molecular interactions within the T4 binding site by molecular docking simulations. Utilizing this combined experimental and computational approach, we demonstrated that sulfation significantly improves the amyloid inhibiting properties as compared to both parent and hydroxylated PCBs. Importantly, several PCB sulfates were of equal or higher potency than some of the most effective previously described inhibitors.

Published
2015

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