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9 results on '"Haznedaroglu, Seminur"'

6. Equivalence of Various Language Versions of Lupus Specific Patient Reported Outcomes Measure (LupusPRO)

Author

Jolly, Meenakshi, Kosinski, Mark, Toloza, Sergio M. A., Block, Joel A., Mikolaitis, Rachel A., Duran-Barragan, Sergio, Bertoli, Ana M., Blazevic, Ivana, Vila, Luis M., Cooray, Dilrukshie, Katsaros, Emmanuel P., Torralba, Karina Marianne D., Moldovan, Ioana, Kaya, Arif, Goker, Berna, Haznedaroglu, Seminur, Mehmet Engin Tezcan, Bourre-Tessier, Josiane, Bernatsky, Sasha, Clarke, Ann E., Weisman, Michael H., Navarra, Sandra V., Wallace, Daniel J., and Alarcon, Graciela S.

9. MEFV gene mutations and its impact on the clinical course in ulcerative colitis patients

Author

Seminur Haznedaroglu, E. Ferda Percin, Derya Kan, Candan Tuncer, Hakan Alagozlu, Bilge Tunc, Beytullah Yildirim, Mehmet Derya Demirag, [Yildirim, Beytullah] Gaziosmanpasa Univ, Sch Med, Dept Gastroenterol, TR-60100 Tokat, Turkey -- [Tuncer, Candan] Gazi Univ, Sch Med, Dept Gastroenterol, Ankara, Turkey -- [Kan, Derya -- Percin, E. Ferda] Gazi Univ, Sch Med, Dept Med Genet, Ankara, Turkey -- [Tunc, Bilge] Turkiye Yuksek Ihtisas Hosp, Dept Gastroenterol, Ankara, Turkey -- [Demirag, Mehmet Derya -- Haznedaroglu, Seminur] Gazi Univ, Sch Med, Dept Rheumatol, Ankara, Turkey -- [Alagozlu, Hakan] Cumhuriyet Univ, Sch Med, Dept Gastroenterol, Sivas, Turkey, and Percin, Ferda -- 0000-0001-9317-8155

Subjects
Adult, Male, medicine.medical_specialty, Pathology, medicine.medical_treatment, Immunology, Familial Mediterranean fever, Gene mutation, Compound heterozygosity, Gastroenterology, Rheumatology, Clinical course, Internal medicine, Prevalence, medicine, Humans, Immunology and Allergy, Colitis, MEFV mutation, Colectomy, business.industry, Middle Aged, Pyrin, medicine.disease, MEFV, Ulcerative colitis, Cytoskeletal Proteins, Phenotype, Rheumatoid arthritis, Disease Progression, Colitis, Ulcerative, Female, business
Abstract

WOS: 000291986900003, PubMed ID: 20224922, Ulcerative colitis (UC) is an inflammatory disease of the colonic mucosa. The presence of gene responsible for FMF, MEFV, which frequently causes inflammation, may aggravate the clinical course of UC. We aimed to determine the prevalence of MEFV mutations in UC patients and its impact on the clinical course. Four groups were formed as group 1 UC with distal disease, group 2 UC with pancolonic disease, group 3 UC with total colectomy, and group 4 Rheumatoid Arthritis (RA) patients. Eleven mutations of FMF gene were investigated. The mean age of group 1, 2, 3, and 4 were 46.7 +/- A 13.9, 43.8 +/- A 12.9, 44.8 +/- A 14.2, and 45.8 +/- A 10.9 years, respectively. The mutations were identified in 19 of the 54 UC patients (35.2%). Homozygous E148Q in 2 patients (3.7%) and heterozygous in 17 patients (31.5%) (E148Q 11.1%, M694V 5.6%, V726A 5.6%, K695R 1.8%, M680I 1.8%, and compound heterozygous 5.6%) were determined. Frequencies of MEFV mutations in group 1, 2, and 3 were 30, 27.3, and 58.3%, respectively. The mutations were identified in 3 of the 20 RA patients (15%). All of them were heterozygous. The rate of MEFV mutations were higher in group 3 than in group 4 (P = 0.018), and the number of attacks that were treated with steroid in all UC patients with mutation positive was higher than in mutation negative (P = 0.016). FMF gene mutations may be identified in UC patients up to 58.3%. It may be suggested that the UC patients with severe form should be identified for MEFV mutations before the judgment of colectomy., Gazi University [01/2007-44], This project was funded by The Society of Science Research Projects in Gazi University, Project number: 01/2007-44.

Published
2011

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