Search

Solar eruptions often show the rotation of filaments, which is a manifestation of the rotation of erupting magnetic flux rope (MFR). Such a rotation of MFR can be induced by either the torque exerted by a background shear-field component (which is an external cause) or the relaxation of the magnetic twist of the MFR (an internal cause). For a given chirality of the erupting field, both the external and internal drivers cause the same rotation direction. Therefore, it remains elusive from direct observations which mechanism yields the dominant contribution to the rotation. In this paper, we exploit a full MHD simulation of solar eruption by tether-cutting magnetic reconnection to study the mechanism of MFR rotation. In the simulation, the MFR’s height–rotation profile suggests that the force by the external shear-field component is a dominant contributor to the rotation. Furthermore, the torque analysis confirms that it is also the only factor in driving the counterclockwise rotation. On the contrary, the Lorentz torque inside the MFR makes a negative effect on this counterclockwise rotation.

Artificial neural networks have realized incredible successes at image recognition, but the underlying mechanism of visual space representation remains a huge mystery. Grid cells (2014 Nobel Prize) in the entorhinal cortex support a periodic representation as a metric for coding space. Here, we develop a self-supervised convolutional neural network to perform visual space location, leading to the emergence of single-slit diffraction and double-slit interference patterns of waves. Our discoveries reveal the nature of CNN encoding visual space to a certain extent. CNN is no longer a black box in terms of visual spatial encoding, it is interpretable. Our findings indicate that the periodicity property of waves provides a space metric, suggesting a general role of spatial coordinate frame in artificial neural networks.

Background/aim Osteosarcoma (OS) is a diagnosed primary cancer of the bone. Despite the great advances that have been made during the past decades in OS therapy, drug resistance and tumor recurrence are still major problems. It is urgent to find novel strategies to overcome drug resistance in order to prolong the survival time of OS patients. Materials and methods Cell viability was investigated by the cell count kit-8 (CCK-8) and colony formation assays. P-Glycoprotein (P-gp) expression was analyzed by RT-qPCR and western blot. A xenograft mouse model was used to identify the synergistic efficacy of a P-gp inhibitor with cisplatin. Student's t-test was used to determine statistically significant differences. Results P-gp expression levels were associated with cisplatin efficacy in OS patients. OS cells with higher P-gp expression were more resistant to cisplatin. Knockdown or inhibition of P-gp sensitized OS cells to cisplatin. Conclusion Down-regulating the expression of P-gp in OS maybe a promising strategy to overcome cisplatin resistance.

Lei Wang, Kai Zhang, Yongqiang Hao, Ming Liu, Wen WuDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, People’s Republic of ChinaAbstract: The porous surface of a polyetheretherketone (PK)–nanoporous lithium-doped magnesium silicate (NLS) blend (PKNLS) was fabricated on a PK surface by layer-by-layer pressuring, sintering, and salt-leaching. As controls, porous surfaces of a PK/lithium-doped magnesium silicate blend (PKLS) and PK were fabricated using the same method. The results revealed that porosity, water absorption, and protein absorption of the porous surface of PKNLS containing macropores and nanopores were obviously enhanced compared to PKLS and PK containing macropores without nanopores. In addition, PKNLS, with both macroporostiy and nanoporosity, displayed the highest ability of apatite mineralization in simulated body liquid, indicating excellent bioactivity. In vitro responses (including adhesion, proliferation, and differentiation) of MC3T3E1 cells to PKNLS were significantly enhanced compared to PKLS and PK. In vivo implantation results showed that new bone grew into the macroporous surface of PKNLS, and the amount of new bone for PKNLS was the highest. In short, PKNLS integration with PK significantly promoted cells/bone-tissue responses and exhibited excellent osteogenesis in vivo, which might have great potential for bone repair.Keywords: polyetheretherketone, nanoporous lithium doped magnesium silicate, porously bioactive surface, cells responses, osteogenesis

Objective: To investigate the effect of entangled titanium fibre balls (ETFBs) combined with nano strontium hydroxyapatite (nano-Sr-HAP) on the repair of bone defects in vivo. Materials and Methods: Twenty-four 6-month-old, specific pathogen-free, male Sprague-Dawley rats were used. Drill defects were created in bilateral femoral condyles. ETFBs combined with nano-Sr-HAP were selected randomly from 72 samples and implanted into the femoral bone defects of left legs, which served as the experimental group, while ETFBs without nano-Sr-HAP were implanted into right legs for comparison. The bone defects on both sides were X-rayed. The anteroposterior positions and histological procedures and evaluations of each sample were performed at 1, 2, 4 and 8 weeks post-surgery. Results: Histological results showed that the ETBs allowed new bone to grow within their structure. Additionally, an increase in new bone was seen on the nano-Sr-HAP side compared to the control side. The results of histomorphometric analysis confirmed that the new bone formation on the left side gradually increased with time. There was a statistical increase in new bone at 2, 4 and 8 weeks, and the differences between the two sides were statistically significant at weeks 4 and 8 (p < 0.05 for all comparisons). Conclusion: The results showed that ETFBs possess a unique 3-dimensional interconnective porous structure and have excellent biocompatibility, cell affinity and osteoconductivity, which makes them useful as scaffold materials for repairing bone defects. On the other hand, nano-Sr-HAP improved the bone defect-repairing capacity of the ETFBs, which showed osteoinductive properties.