661 results on '"Hao, Hua"'
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2. Flux Reversal Permanent Magnet Machines with Single-Layer Non-Overlapping Windings
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Hao Hua and Z.Q. Zhu
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Energy Engineering and Power Technology ,Electrical and Electronic Engineering - Published
- 2023
3. Precise Rehabilitation Strategies for Functional Impairment in Children with Cerebral Palsy
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Yaojin Sun, Nan Jiang, Min Zhu, and Hao Hua
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Computational Theory and Mathematics ,Artificial Intelligence ,Software ,Theoretical Computer Science - Published
- 2023
4. Automatic Myotendinous Junction Identification in Ultrasound Images Based on Junction-Based Template Measurements
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Guang-Quan Zhou, Shi-Hao Hua, Yikang He, Kai-Ni Wang, Dandan Zhou, Hongxing Wang, and Ruoli Wang
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General Neuroscience ,Rehabilitation ,Biomedical Engineering ,Internal Medicine - Published
- 2023
5. Investigation of Delta-Type Variable Flux Memory Machines Considering Magnetizing Current Limits
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Hao Hua, Zicheng Zhou, Xiaomei Yin, and Bohu Zhang
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Control and Systems Engineering ,Electrical and Electronic Engineering ,Industrial and Manufacturing Engineering - Published
- 2023
6. Winding Characteristics and Magnetization State Regulations of Variable Flux Memory Machines with Segregated Distributed Windings
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Hao Hua and Wei Hua
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Control and Systems Engineering ,Electrical and Electronic Engineering - Published
- 2023
7. Utility of Spine Surgery Fellowship Training for Orthopaedic Surgeons in the United States
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Jason Silvestre, Hao Hua Wu, Terry L. Thompson, and James D. Kang
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Orthopedics and Sports Medicine ,Surgery - Published
- 2022
8. Perioperative Outcomes of Open Anterior Vertebral Body Tethering and Instrumented Posterior Spinal Fusion for Skeletally Immature Patients With Idiopathic Scoliosis
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Jeremy W. Siu, Hao-Hua Wu, Satvir Saggi, Sachin Allahabadi, Toshali Katyal, and Mohammad Diab
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Pediatrics, Perinatology and Child Health ,Orthopedics and Sports Medicine ,General Medicine - Published
- 2022
9. Feature Selection Assists BLSTM for the Ultrasensitive Detection of Bioflavonoids in Different Biological Matrices Based on the 3D Fluorescence Spectra of Gold Nanoclusters
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Hamada A. A. Noreldeen, Kai-Yuan Huang, Gang-Wei Wu, Qi Zhang, Hua-Ping Peng, Hao-Hua Deng, and Wei Chen
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Flavonoids ,Spectrometry, Fluorescence ,Metal Nanoparticles ,Gold ,Body Fluids ,Analytical Chemistry - Abstract
Rapid and on-site qualitative and quantitative analysis of small molecules (including bioflavonoids) in biofluids are of great importance in biomedical applications. Herein, we have developed two deep learning models based on the 3D fluorescence spectra of gold nanoclusters as a single probe for rapid qualitative and quantitative analysis of eight bioflavonoids in serum. The results proved the efficiency and stability of the random forest-bidirectional long short-term memory (RF-BLSTM) model, which was used only with the most important features after deleting the unimportant features that might hinder the performance of the model in identifying the selected bioflavonoids in serum at very low concentrations. The optimized model achieves excellent overall accuracy (98-100%) in the qualitative analysis of the selected bioflavonoids. Next, the optimized model was transferred to quantify the selected bioflavonoids in serum at nanoscale concentrations. The transferred model achieved excellent accuracy, and the overall determination coefficient (R
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- 2022
10. The Senescence-Related Signature Predicts Prognosis and Characterization of Tumor Microenvironment Infiltration in Pancreatic Cancer
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Hao Hua, Chenglong Zheng, Jiling Fan, Xiushen Li, Wenfeng Xie, Jinxin Chen, and Chao Yu
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Article Subject ,General Immunology and Microbiology ,General Medicine ,General Biochemistry, Genetics and Molecular Biology - Abstract
Background. Senescence is thought to be an imperative effect on the development of cancer. However, few studies pay an attention to the senescence-associated genes in pancreatic cancer (PC). The prognostic value of senescence-related genes (SRGs) and their involvement in tumor microenvironment (TME) in the PC remain obscure. The aim of this research was to investigate the prognostic role of senescence-associated genes and their affection in TME in PC. Methods. The transcriptome and clinical information of PC patients were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Two SRG-mediated molecular clusters were comprehensively identified. In total, data from the 285 PC patients were randomly used to develop a senescence-associated gene signature in the training set and verified in the validation set. Immune microenvironment analysis pertained to senescence-related genes was performed. Results. A SRG_score including five senescence-associated genes was established to separate PC patients into two risk groups. High-risk patients had worse overall survival than low-risk patients. The result of the multivariate Cox regression analysis identified the risk score and stage as independent prognostic factors for PC patients. Receiver operating characteristic curve (ROC) analysis confirmed the credible predictive ability of the nomogram. The area under time-dependent ROC curve (AUC) reached 0.746 at 1 year, 0.781 at 3 years, and 0.868 at 5 years in the training set and 0.653 at 1 year, 0.755 at 3 years, and 0.785 at 5 years in the validation set. Moreover, the SRG_score was associated with TME, tumor mutation burden (TMB), and chemotherapeutic drug sensitivity. Conclusions. This study found that the novel SRG_score could be an independent prognostic target for PC patients. Senescence-associated genes had a vital impact on the immune microenvironment and the treatment of PC patients.
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- 2022
11. Plastome characteristics and species identification of Chinese medicinal wintergreens (Gaultheria, Ericaceae)
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Yan-Ling Xu, Hao-Hua Shen, Xin-Yu Du, and Lu Lu
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Plant Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
12. Machine learning–based sensor array: full and reduced fluorescence data for versatile analyte detection based on gold nanocluster as a single probe
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Hamada A A, Noreldeen, Shao-Bin, He, Kai-Yuan, Huang, Chen-Ting, Zhu, Qing-Lin, Zhou, Hua-Ping, Peng, Hao-Hua, Deng, and Wei, Chen
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Ions ,Machine Learning ,Spectrometry, Fluorescence ,Metals, Heavy ,Metal Nanoparticles ,Gold ,Biochemistry ,Analytical Chemistry - Abstract
Different acquisition data approaches have been used to fetch the fluorescence spectra. However, the comparison between them is rare. Also, the extendability of a sensor array, which can work with heavy metal ions and other types of analytes, is scarce. In this study, we used first- and second-order fluorescent data generated by 6-Aza-2-thiothymine-gold nanocluster (ATT-AuNCs) as a single probe along with machine learning to distinguish between a group of heavy metal ions. Moreover, the dimensionality reduction was carried out for the different acquisition data approaches. In our case, the accuracy of different machine learning algorithms using first-order data outperforms the second-order data before and after the dimensionality reduction. For proving the extendibility of this approach, four anions were used as an example. As expected, the same finding has been found. Furthermore, random forest (RF) showed more stable and accurate results than other models. Also, linear discriminant analysis (LDA) gave acceptable accuracy in the analysis of the high-dimensionality data. Accordingly, using LDA in high-dimensionality data (the first- and second-order data) analysis was highlighted for discrimination between the selected heavy metal ions in different concentrations and in different molar ratios, as well as in real samples. Also, the same method was applied for the anion's discrimination, and LDA gave an excellent separation ability. Moreover, LDA was able to differentiate between all the selected analytes with excellent separation ability. Additionally, the quantitative detection was considered using a wide concentration range of Cd
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- 2022
13. Thoracic posterior spinal instrumented fusion vs. thoracic anterior spinal tethering for adolescent idiopathic scoliosis with a minimum of 2-year follow-up: a cost comparison of index and revision operations
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Alekos A. Theologis, Hao-Hua Wu, and Mohammad Diab
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Orthopedics and Sports Medicine - Abstract
To compare direct costs of index and revision operations of thoracic posterior spinal instrumented fusion (TPSIF) and thoracic anterior spinal tethering (TAST) for adolescent idiopathic thoracic scoliosis in children.Children (ages 11-18 years) who underwent TPSIF and TAST (2/2013-9/2019) were reviewed. Follow-up 2 years and cervical instrumentation and/or instrumentation of a lumbar level at L3 or below were exclusion criteria. Patient demographics, radiographic curve magnitude, index operations and postoperative data, as well as indications for revisions/readmissions were collected. Direct costs were identified and compared for index and revision operations during follow-up.One hundred and four patients were included (TPSIF: 78; TAST: 25). TAST procedures were performed in children significantly younger and for smaller curve magnitudes. They had significantly fewer levels instrumented, shorter operating room (OR) times, and less estimated blood loss (EBL). After operation, a significantly higher percentage of TAST were admitted to ICU. Hospital length of stay (LOS) was similar between groups. Index operations' average direct costs were significantly higher for TAST than TPSIF ($52,947 v. $46,641; p = 0.02). Major cost drivers for both groups were implants, OR services, post-anesthesia care unit (PACU), and room/board. Revisions following TAST were more frequent than for TPSIF (36 v. 11.5%). Majority of TPSIF revisions were for junctional deformity. Curve progression and overcorrection were most common reason for TAST revisions. Average direct costs for revisions/readmissions were similar between groups (TPSIF: $28,485 v. TAST: $27,590; p = 0.46).Index operations' average direct costs were statistically similar between TPSIF and TAST for adolescent idiopathic scoliosis. Major cost drivers were implants, OR services, PACU, and room/board. TAST index operations' direct costs and associated direct costs for implants and room/board were significantly higher, while their anesthesia and OR services were significantly lower than TPSIF. TAST revisions were for overcorrection and curve progression, while TPSIF revisions were most commonly for junctional deformity. Overall average direct costs for revisions were similar despite revision rates being higher for TAST.III.
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- 2022
14. Increased drought effects on the phenology of autumn leaf senescence
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Chaoyang Wu, Jie Peng, Philippe Ciais, Josep Peñuelas, Huanjiong Wang, Santiago Beguería, T. Andrew Black, Rachhpal S. Jassal, Xiaoyang Zhang, Wenping Yuan, Eryuan Liang, Xiaoyue Wang, Hao Hua, Ronggao Liu, Weimin Ju, Yongshuo H. Fu, Quansheng Ge, Chinese Academy of Sciences, National Natural Science Foundation of China, European Commission, Fundación Ramón Areces, Agencia Estatal de Investigación (España), Generalitat de Catalunya, Beguería, Santiago, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and This work was funded by the Strategic Priority Research Programme of the Chinese Academy of Sciences (XDA19040103), the National Natural Science Foundation of China (42125101) and the CAS Interdisciplinary Innovation Team (JCTD-2020-05). J.P. and P.C. were funded by European Research Council Synergy grant ERC-SyG-2013-610028 IMBALANCE-P. J.P. was also financially supported by the Fundación Ramon Areces grant ELEMENTAL-CLIMATE, the Spanish Government grant PID2019-110521GB-I00 and the Catalan Government grant SGR 2017-1005.
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[SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere ,Take urgent action to combat climate change and its impacts ,date of foliar senescence ,Terrestrial ecosystem ,carbon storage ,Environmental Science (miscellaneous) ,[SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment ,season ,climate ,Social Sciences (miscellaneous) - Abstract
10 pags.- 4 Figs. Under Licence CC BY 4.0, Global warming delays the autumn date of foliar senescence (DFS) in recent decades, with positive implications for growing season length and therefore global carbon storage. However, warming-associated drought, leading to water limitation, may conversely stimulate earlier DFS. Using ground observations since 1940s and 34 years of satellite greenness data (1982‒2015) over the Northern Hemisphere (>30° N), we show the increased impact of drought on DFS. Earlier DFS is linked to decreased precipitation under warming and weaker drought resistance associated with various plant functional traits. For example, isohydric plants with strict regulation of water status may drop leaves fast during droughts. We derive an improved set of phenology models based on this influence and project earlier DFS by the end of the century, particularly at high latitudes (>50° N). Our results limit uncertainties in the later end of plant growth with warming, aiding estimation of carbon uptake of terrestrial ecosystems., This work was funded by the Strategic Priority Research Programme of the Chinese Academy of Sciences (XDA19040103), the National Natural Science Foundation of China (42125101) and the CAS Interdisciplinary Innovation Team (JCTD-2020-05). J.P. and P.C. were funded by European Research Council Synergy grant ERC-SyG-2013-610028 IMBALANCE-P. J.P. was also financially supported by the Fundación Ramon Areces grant ELEMENTAL-CLIMATE, the Spanish Government grant 2013-610028 and the Catalan Government grant SGR 2017-1005.
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- 2022
15. Exploration and design of knitted composites for architectural application: The MeiTing project
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Yige Liu, Hao Hua, and Biao Li
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Urban Studies ,Archeology ,Architecture ,Building and Construction - Published
- 2022
16. Precise Detection and Quantitative Prediction of Blood Glucose Level With an Electronic Nose System
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Zhenyi Ye, Jie Wang, Hao Hua, Xiangdong Zhou, and Qiliang Li
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Electrical and Electronic Engineering ,Instrumentation - Published
- 2022
17. Erratum: Rates of readmission and reoperation after operative management of midshaft clavicle fractures in adolescents
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Carrillo, Laura A, Wu, Hao Hua, Callahan, Matt, Chopra, Aman, Katyal, Toshali, and Swarup, Ishaan
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Reoperation ,Good Health and Well Being ,Adolescent ,Clavicle fracture ,Correction ,Readmission - Abstract
[This corrects the article on p. 1001 in vol. 12, PMID: 35036342.].
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- 2023
18. Comparison of lipid accumulation product and visceral adiposity index with traditional obesity indices in early-onset type 2 diabetes prediction: a cross-sectional study
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Chen-Ying Lin, Jing-Bo Li, Fan Wu, Jun-Jia Wang, Hao-Hua An, Hui-Na Qiu, Long-Fei Xia, Yao-Shuang Li, Ya-Jie Zhai, Chun-Jun Li, and Jing-Na Lin
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Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Background The purpose of the study was to compare the efficacy of two novel obesity indices, lipid accumulation product (LAP) and visceral adiposity index (VAI), with traditional obesity indices in predicting early-onset type 2 diabetes (T2DM). Methods In this cross-sectional study, a total of 744 participants, including 605 patients newly diagnosed with T2DM and 139 non-diabetic control subjects, were enrolled from a tertiary care hospital in Tianjin, China. Participants with T2DM were divided into two groups based on their age at diagnosis, namely early-onset T2DM (age less than 40 years, n = 154) and late-onset T2DM (age 40 years or older, n = 451). The predictive power of each obesity index was evaluated using receiver operating characteristic (ROC) curve analysis. Furthermore, binary logistic regression analysis was conducted to examine the independent relationship between LAP and VAI with early-onset T2DM risk. The relationship between novel obesity indices and the age of T2DM onset was also evaluated through correlation and multiple linear regression analysis. Results In males, LAP had the highest predictive power for early-onset T2DM with an area under the ROC curve (AUC) of 0.742 (95% CI 0.684–0.799, P Conclusions In young Chinese individuals, LAP and VAI are recommended over traditional obesity indices for improved prediction of early-onset T2DM risk.
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- 2023
19. Posterior Displacement of L1 May be a Risk Factor for Proximal Junctional Kyphosis After Adult Spinal Deformity Correction
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Xi, Zhuo, Duan, Ping-Guo, Mummaneni, Praveen V, Liu, Jinping, Guinn, Jeremy MV, Wang, Minghao, Li, Bo, Wu, Hao-Hua, Rivera, Joshua, Burch, Shane, Berven, Sigurd H, and Chou, Dean
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Clinical Research ,Prevention ,adult spinal deformity ,proximal junctional kyphosis ,L1 ,PJK ,L1PL ,gravity line - Abstract
Study designRetrospective cohort study.ObjectiveOvercorrection in adult spinal deformity (ASD) surgery may lead to proximal junctional kyphosis (PJK) because of posterior spinal displacement. The aim of this paper is to determine if the L1 position relative to the gravity line (GL) is associated with PJK.MethodsASD patients fused from the lower thoracic spine to sacrum by 4 spine surgeons at our hospital were retrospectively studied. Lumbar-only and upper thoracic spine fusions were excluded. Spinopelvic parameters, the L1 plumb line (L1PL), L1 distance to the GL (L1-GL), and Roussouly type were measured.ResultsOne hundred fourteen patients met inclusion criteria (63 patients with PJK, 51 without). Mean age and follow up was 65.51 and 3.39 years, respectively. There was no difference between the PJK and the non-PJK groups in baseline demographics, pre-operative and immediate post-operative pelvic incidence-lumbar lordosis mismatch, sagittal vertical axis, or coronal Cobb. The immediate postoperative L1-GL was -7.24 cm in PJK and -3.45 cm in non-PJK (P < 0.001), L1PL was 1.71 cm in PJK and 3.07 cm in non-PJK (P = 0.004), and PT (23.76° vs 18.90°, P = 0.026) and TK (40.56° vs 31.39°, P < 0.001) were larger in PJK than in non-PJK. After univariate and multivariate analyses, immediate postoperative TK and immediate postoperative L1-GL were independent risk factors for PJK without collinearity.ConclusionsA dorsally displaced L1 relative to the GL was associated with an increased risk of PJK after ASD surgery. The postoperative L1-GL distance may be a factor to consider during ASD surgery.
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- 2023
20. A Hybrid Multimodal Emotion Recognition Framework for UX Evaluation Using Generalized Mixture Functions
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Muhammad Asif Razzaq, Jamil Hussain, Jaehun Bang, Cam-Hao Hua, Fahad Ahmed Satti, Ubaid Ur Rehman, Hafiz Syed Muhammad Bilal, Seong Tae Kim, and Sungyoung Lee
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emotion recognition ,user experience ,audio-based emotion recognition ,feature fusioning ,decision fusioning ,generalized mixture function ,Electrical and Electronic Engineering ,Biochemistry ,Instrumentation ,Atomic and Molecular Physics, and Optics ,Analytical Chemistry - Abstract
Multimodal emotion recognition has gained much traction in the field of affective computing, human–computer interaction (HCI), artificial intelligence (AI), and user experience (UX). There is growing demand to automate analysis of user emotion towards HCI, AI, and UX evaluation applications for providing affective services. Emotions are increasingly being used, obtained through the videos, audio, text or physiological signals. This has led to process emotions from multiple modalities, usually combined through ensemble-based systems with static weights. Due to numerous limitations like missing modality data, inter-class variations, and intra-class similarities, an effective weighting scheme is thus required to improve the aforementioned discrimination between modalities. This article takes into account the importance of difference between multiple modalities and assigns dynamic weights to them by adapting a more efficient combination process with the application of generalized mixture (GM) functions. Therefore, we present a hybrid multimodal emotion recognition (H-MMER) framework using multi-view learning approach for unimodal emotion recognition and introducing multimodal feature fusion level, and decision level fusion using GM functions. In an experimental study, we evaluated the ability of our proposed framework to model a set of four different emotional states (Happiness, Neutral, Sadness, and Anger) and found that most of them can be modeled well with significantly high accuracy using GM functions. The experiment shows that the proposed framework can model emotional states with an average accuracy of 98.19% and indicates significant gain in terms of performance in contrast to traditional approaches. The overall evaluation results indicate that we can identify emotional states with high accuracy and increase the robustness of an emotion classification system required for UX measurement.
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- 2023
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21. Deep Learning-Based Sensor Array: 3D Fluorescence Spectra of Gold Nanoclusters for Qualitative and Quantitative Analysis of Vitamin B6 Derivatives
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Hamada A. A. Noreldeen, Kai-Yuan Huang, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, and Wei Chen
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Analytical Chemistry - Published
- 2022
22. Effects of subanesthesia dose S‐ketamine induction on postoperative psychiatric complications after gynecological surgery
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Fan Zhang, Jun Ding, Man Luo, Hao‐Hua Luo, Xiao‐Lin Sun, Xu Fang, Lei Chen, Jun Tao, and Zhao‐Qiong Zhu
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- 2022
23. QTL mapping for plant architecture in rice based on chromosome segment substitution lines
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Xiao-Lei WANG, Wei-Xing LI, Lin-Juan OU-YANG, Jie XU, Xiao-Rong CHEN, Jian-Min BIAN, Li-Fang HU, Xiao-Song PENG, Xiao-Peng HE, Jun-Ru FU, Da-Hu ZHOU, Hao-Hua HE, Xiao-Tang SUN, and Chang-Lan ZHU
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Plant Science ,Agronomy and Crop Science ,Biotechnology - Published
- 2022
24. Design of infrared stellar radiation quantitative observation system
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Jin-bao YANG, Ya-chao LIU, Xiao-ting ZHAI, Chen YANG, Ting LI, Long-ting LI, and Hao HUA
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- 2023
25. Anterior vertebral body tethering for adolescent idiopathic scoliosis associated with less early post-operative pain and shorter recovery compared with fusion
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Jennifer M. O’Donnell, Alex L. Gornitzky, Hao-Hua Wu, Kira S. Furie, and Mohammad Diab
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Orthopedics and Sports Medicine - Abstract
Purpose While posterior spinal instrumentation and fusion (PSIF) for severe adolescent idiopathic scoliosis (AIS) is the gold standard, anterior vertebral body tethering (AVBT) is becoming an alternative for select cases. Several studies have compared technical outcomes for these two procedures, but no studies have compared post-operative pain and recovery. Methods In this prospective cohort, we evaluated patients who underwent AVBT or PSIF for AIS for a period of 6 weeks after operation. Pre-operative curve data were obtained from the medical record. Post-operative pain and recovery were evaluated with pain scores, pain confidence scores, PROMIS scores for pain behavior, interference, and mobility, and functional milestones of opiate use, independence in activities of daily living (ADLs), and sleeping. Results The cohort included 9 patients who underwent AVBT and 22 who underwent PSIF, with a mean age of 13.7 years, 90% girls, and 77.4% white. The AVBT patients were younger (p = 0.03) and had fewer instrumented levels (p = 0.03). Results were significant for decreased pain scores at 2 and 6 weeks after operation (p = 0.004, and 0.030), decreased PROMIS pain behavior at all time points (p = 0.024, 0.049, and 0.001), decreased pain interference at 2 and 6 weeks post-operative (p = 0.012 and 0.009), increased PROMIS mobility scores at all time points (p = 0.036, 0.038, and 0.018), and faster time to functional milestones of weaning opiates, independence in ADLs, and sleep (p = 0.024, 0.049, and 0.001). Conclusion In this prospective cohort study, the early recovery period following AVBT for AIS is characterized by less pain, increased mobility, and faster recovery of functional milestones, compared with PSIF. Level of evidence IV.
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- 2023
26. Case report: Diabetic muscle infarction with diabetic ketoacidosis: A rare complication of diabetes
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Jun Tang, Li Sun, Qi Huang, Yu-Wen Wu, Xin Li, Hao-Hua Deng, Jia-Zhong Sun, Zhe Dai, and Yan-Cheng Xu
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Endocrinology, Diabetes and Metabolism - Abstract
BackgroundDiabetic muscle infarction (DMI), which is also referred to as diabetic myonecrosis, is a rare and long-term complication of poorly controlled diabetes mellitus, while we found that acute diabetes decompensation, such as diabetic ketoacidosis (DKA), could also stimulate the occurrence and development of DMI.Case presentationA 23-year-old woman with type 1 diabetes presented with a 10-day history of nausea, vomiting, pain, and swelling of her left leg. Her urine ketone test was positive. The 3-beta-hydroxybutyrate and leukocyte counts and creatine kinase levels were elevated. Magnetic resonance imaging of the left thigh revealed extensive deep tissue oedema and an increase in the T2 signal in the involved muscles. Once the diagnosis of DMI was made, she was managed with rest, celecoxib, clopidogrel and aggressive insulin therapy. Three months after treatment, the patient reported complete resolution of symptoms.ConclusionDMI is a rare DM complication with a high recurrence rate, commonly presenting with chronic complications, while our case report shows that acute diabetes decompensation, such as DKA, can stimulate the occurrence and development of DMI. Timely diagnosis and appropriate treatment could shorten the recovery time.
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- 2023
27. RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by Activating PI3K/Akt Signaling Pathway
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Hao Hua, Huahua Xie, Jian Zheng, Linhan Lei, Zilei Deng, and Chao Yu
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Aging ,Article Subject ,Cell Biology ,General Medicine ,Biochemistry - Abstract
RING finger protein-7 (RNF7) functions as a positive regulator in the progression of multiple malignancies. However, the underlying mechanism by which RNF7 contributes to pancreatic cancer (PC) is lacking. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to test the level of RNF7expression in PC cell lines and tissues. The role of RNF7 in PC tumorigenesis was analyzed by Cell Counting Kit-8 (CCK-8). 5-Ethynyl-20-deoxyuridine (EdU), wound-healing/Transwell assays, as well as a subcutaneous tumorigenesis model were constructed to assess the role of RNF7 in PC cells. The association between RNF7 and PI3K/Akt signaling were assessed by western blot and further confirmed by rescue experiments. The PC patients with upregulated expression of RNF7 had poor survival. Overexpression of RNF7 significantly facilitated PC proliferative and migrative and invasive properties in vitro and vivo; however, knockdown of RNF7exhibited the opposite results. Mechanistically, RNF7 promoted PANC-1 and SW1990 cell growth through impacting the activation of the PI3K/Akt signaling pathway. Our data demonstrated that RNF7 promoted PC tumorigenesis via activating the PI3K/Akt signaling pathway and might be regarded as one of the potential therapies to PC.
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- 2023
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28. Digital and physical materiality in contemporary architectural design: A material engagement approach
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Kostas Grigoriadis, Kåre Stokholm Poulsgaard, and Hao Hua
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Urban Studies ,Archeology ,Architecture ,Building and Construction - Published
- 2022
29. A peroxidase-like activity-based colorimetric sensor array of noble metal nanozymes to discriminate heavy metal ions
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Hao-Hua Deng, Shao-Bin He, Xiao-Yun Guo, Liu Yang, Hamada A. A. Noreldeen, Wei Chen, and Hua-Ping Peng
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Ions ,Metal ions in aqueous solution ,Inorganic chemistry ,chemistry.chemical_element ,Colorimetric sensor array ,engineering.material ,Biochemistry ,Analytical Chemistry ,Peroxidases ,chemistry ,Sensor array ,Tap water ,Metals, Heavy ,Peroxidase like ,Electrochemistry ,engineering ,Humans ,Environmental Chemistry ,Colorimetry ,Osmium ,Noble metal ,Platinum ,Spectroscopy - Abstract
Heavy metal ions (HMIs), including Cu2+, Ag+, Cd2+, Hg2+, and Pb2+ from the environment pose a threat to human beings and can cause a series of life-threatening diseases. Therefore, colorimetric sensors with convenience and flexibility for HMI discrimination are still required. To provide a solution, a peroxidase-like activity-based colorimetric sensor array of citrate-capped noble metal nanozymes (osmium, platinum, and gold) has been fabricated. Some studies reported that some HMIs could interact with the noble metal nanozymes leading to a change in their peroxidase-like activity. This phenomenon was confirmed in our work. Based on this principle, different concentrations of HMIs (Cu2+, Ag+, Cd2+, Hg2+, and Pb2+) were discriminated. Moreover, their practical application has been tested by discriminating HMIs in tap water and SiYu lake water. What is more, as an example of the validity of our method to quantify HMIs at nanomolar concentrations, the LOD of Hg2+ was presented. To sum up, our study not only demonstrates the differentiation ability of this nanozyme sensor array but also gives hints for using nanozyme sensor arrays for further applications.
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- 2022
30. Analytical Prediction of Torque of Switched Reluctance Machines Considering Nonlinear Characteristics
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Wei Hua and Hao Hua
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Permeance ,Magnetic flux ,Switched reluctance motor ,symbols.namesake ,Nonlinear system ,Magnetomotive force ,Control and Systems Engineering ,Control theory ,Electromagnetic coil ,symbols ,Torque ,Electrical and Electronic Engineering ,Lorentz force ,Mathematics - Abstract
In this paper, an analytical method (AM) based on the air-gap magnetomotive force (MMF) permeance model is proposed to predict the nonlinear instantaneous torque of switched reluctance machines (SRMs). The analytical expression of the air-gap MMF is first obtained from the winding function and current profile, while the air-gap magnetic permeance considering the double-sided slotting effects is also derived. Then, the nonsaturated field distribution along the air-gap circumference is presented based on which the instantaneous torque can be calculated from the Lorentz force law. Furthermore, the model is enhanced with a saturation distribution factor to include the nonlinear characteristics. The proposed method is free from preliminary data or empirical coefficient and benefits from the simplified model and solution. The AM will be validated by the two-dimensional finite-element method based on four SRMs with different structures. Moreover, an SRM prototype is manufactured for experimental verification.
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- 2022
31. An Improved Genetic Algorithm for Berth Scheduling at Bulk Terminal
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Xiaona Hu, Shan Ji, Hao Hua, Baiqing Zhou, and Gang Hu
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General Computer Science ,Control and Systems Engineering ,Theoretical Computer Science - Published
- 2022
32. Selfish Mining and Defending Strategies in the Bitcoin
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Weijian Zhang, Hao Wang, Hao Hua, and Qirun Wang
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Computational Theory and Mathematics ,Artificial Intelligence ,Software ,Theoretical Computer Science - Published
- 2022
33. Automatic 3-D spine curve measurement in freehand ultrasound via structure-aware reinforcement learning spinous process localization
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Qi-Yong Ran, Juzheng Miao, Si-Ping Zhou, Shi-hao Hua, Si-Yuan He, Ping Zhou, Hong-Xing Wang, Yong-Ping Zheng, and Guang-Quan Zhou
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Acoustics and Ultrasonics - Published
- 2023
34. Rates of readmission and reoperation after operative management of midshaft clavicle fractures in adolescents
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Laura A Carrillo, Hao-Hua Wu, Aman Chopra, Matt Callahan, Toshali Katyal, and Ishaan Swarup
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Reoperation ,Adolescent ,Retrospective Study ,Clavicle fracture ,Orthopedics and Sports Medicine ,Readmission - Abstract
BACKGROUND: The national rates of readmission and reoperation after open reduction internal fixation (ORIF) of midshaft clavicle fractures in adolescents is unknown. AIM: To determine rates of and risk factors for readmission and reoperation after ORIF of midshaft clavicle fractures in adolescents. METHODS: This retrospective study utilized data from the Healthcare Cost and Utilization Project State Inpatient Database for California and Florida and included 11728 patients 10-18 years of age that underwent ORIF of midshaft clavicle fracture between 2005 and 2012. Readmissions within ninety days, reoperations within two years, and differences in patient demographic factors were determined through descriptive, univariate, and multivariate analyses. RESULTS: In total, 3.29% (n = 11) of patients were readmitted within 90 d to a hospital at an average of 18.91 ± 18 d after discharge, while 15.87% (n = 53) of patients underwent a reoperation within two years at an average of 209.53 ± 151 d since the index surgery. The most common reason for readmission was a postoperative infection (n < 10). Reasons for reoperation included implant removal (n = 49) at an average time of 202.39 ± 138 d after surgery, and revision ORIF (n < 10) with an average time of 297 ± 289 d after index surgery. The odds of reoperation were higher for females (P < 0.01) and outpatients (P < 0.01), while the odds of reoperation were lower for patients who underwent surgery in California (P = 0.02). CONCLUSION: There is a low rate of readmission and a high rate of reoperation after ORIF for midshaft clavicle fractures in adolescents. There are significant differences for reoperation based on patient sex, location, and hospital type.
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- 2021
35. Rates of Operative Management of Midshaft Clavicle Fracture in Adolescents Have Increased in Florida between 2005 and 2014
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Hao-Hua, Wu, Aman, Chopra, Laura A, Carrillo, Matt, Callahan, and Ishaan, Swarup
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Orthopedics and Sports Medicine ,Surgery - Abstract
Background: It is not known if the adult literature on midshaft clavicle fracture treatment with open reduction internal fixation (ORIF) has influenced injury management in adolescents. Purpose: We sought to longitudinally evaluate the rates of operative management of adolescent midshaft clavicle fractures in the state of Florida. Methods: We conducted a retrospective review of data from the following Healthcare Cost and Utilization Project databases: the State Inpatient Database, the State Ambulatory Surgery and Services Database, and the State Emergency Department Database. Patients in Florida ages 10 to 18 years with midshaft clavicle fractures between 2005 and 2014 were identified along with data on age, sex, race/ethnicity, insurance type, treatment, and income percentile. We reviewed the data to identify trends in the rates of operative management of midshaft clavicle fractures. We then compared the rates of operative management between the first 3 years and the most recent 3 years (2005–2007 vs 2012–2014). Various demographic and socioeconomic factors were compared between patients treated with and without surgery. Descriptive statistics as well as univariate and multivariate analyses were performed. Results: There were 4297 midshaft clavicle fractures in adolescents identified between 2005 and 2014, and 338 (7.8%) of these fractures underwent operative management. There was a significant increase in the rate of operative management; it increased from 4.3% (n = 59) of the 1373 clavicle fractures that occurred between 2005 and 2007 to 11.2% (n = 130) of the 1164 clavicle fractures that occurred between 2012 and 2014. Patients with commercial insurance and patients who were older were more likely to undergo ORIF. Patients with Medicaid were more likely to undergo ORIF between 2012 and 2014 compared with patients with Medicaid between 2005 and 2007. Conclusions: Operative management rates of adolescent midshaft clavicle fractures have significantly increased in Florida over a decade; additional research is needed to understand these findings.
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- 2021
36. Concurrent and Overlapping Surgery: Perspectives from Surgeons on Spinal Posterior Instrumented Fusion for Adolescent Idiopathic Scoliosis
- Author
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Tiana Woolridge, Mohammad Diab, Hao-Hua Wu, Sachin Allahabadi, Sameer Allahabadi, and Michael Kohn
- Subjects
medicine.medical_specialty ,simultaneous surgery ,business.industry ,Instrumented fusion ,Idiopathic scoliosis ,Overlapping surgery ,Surgery ,Paediatrics and Reproductive Medicine ,Orthopedics ,overlapping ,Musculoskeletal ,adolescent idiopathic scoliosis ,Pediatrics, Perinatology and Child Health ,Original Clinical Article ,medicine ,Orthopedics and Sports Medicine ,concurrent ,business - Abstract
Purpose The purpose of this study was to determine perspectives of surgeons regarding simultaneous surgery in patients undergoing posterior spine instrumentation and fusion (PSIF) for adolescent idiopathic scoliosis (AIS). Methods A survey was administered to orthopaedic trainees and faculty regarding simultaneous surgery for primary PSIF for AIS. A five-point Likert scale (1: ‘Strongly Disagree’ to 5: ‘Strongly Agree’) was used to assess agreement with statements about simultaneous surgery. We divided simultaneous surgery into concurrent, when critical portions of operations occur at the same time, and overlapping, when noncritical portions occur at the same time. Results The 72 respondents (78.3% of 92 surveyed) disagreed with concurrent surgery for ‘one of my patients’ (response mean 1.76 (sd 1.03)) but were more accepting of overlapping surgery (mean 3.94 (sd 0.99); p < 0.0001). The rating difference between concurrent and overlapping surgery was smaller for paediatric and spine surgeons (-1.25) than for residents or those who did not identify a subspecialty (-2.17; p = 0.0246) or other subspecialty surgeons (-2.57; p = 0.0026). Respondents were more likely to agree with explicit informed consent for concurrent surgery compared with overlapping (mean 4.32 (sd 0.91) versus 3.44 (sd 1.14); p < 0.001). Conclusion Orthopaedic surgeons disagreed with concurrent but were more accepting of overlapping surgery and anaesthesia for PSIF for AIS. Respondents were in greater agreement that patients should be explicitly informed of concurrence than of overlap. The surgical community's evidence and position regarding simultaneous surgery, in particular overlapping, must be more effectively presented to the public in order to bridge the gap in perspectives. Level of Evidence IV
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- 2021
37. Circulating tumor cells (CTCs)/circulating tumor endothelial cells (CTECs) and their subtypes in small cell lung cancer: Predictors for response and prognosis
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Yu Feng, Yuankai Shi, Hao-Hua Zhu, Hongyu Wang, Puyuan Xing, Li-Na Zhang, Yutao Liu, Tongmei Zhang, Guilan Dong, and Xingsheng Hu
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Pulmonary and Respiratory Medicine ,Oncology ,Adult ,Male ,medicine.medical_specialty ,Lung Neoplasms ,medicine.medical_treatment ,therapeutic efficacy ,circulating tumor cells ,Blood cell ,Circulating tumor cell ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Initial treatment ,Humans ,Clinical significance ,Prospective Studies ,neoplasms ,RC254-282 ,Aged ,Chemotherapy ,business.industry ,circulating tumor endothelial cells ,Endothelial Cells ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,General Medicine ,Original Articles ,Middle Aged ,Neoplastic Cells, Circulating ,Response to treatment ,Small Cell Lung Carcinoma ,Progression-Free Survival ,medicine.anatomical_structure ,Disease Progression ,Female ,Original Article ,Non small cell ,prognosis ,small cell lung cancer ,business ,No detection - Abstract
Background The aim of the study was to define the clinical significance of circulating tumor cells (CTCs)/circulating tumor endothelial cells (CTECs) and their subtypes in small cell lung cancer (SCLC) patients. Methods CTCs/CTECs and their subtypes were determined using SE‐iFISH technology in 33 SCLC patients before initial treatment (B1), after two cycles of chemotherapy (B2), at the completion of chemotherapy (B3), and disease progression (B4). The correlations with clinical characteristics, progression‐free survival (PFS), and overall survival (OS) were analyzed. Results CTCs and CTECs were detected in 96.6% and 65.5% of patients, respectively. Patients had higher levels of CTCs compared with CTECs in circulation (p, It has been proved in many studies that CTCs can be used as a prognostic biomarker in SCLC patients. Here, we report that CTC‐WBC clusters may also be a valuable predictor for SCLC prognosis. In this study, patients with CTC‐WBC clusters before chemotherapy (17.3 vs. 22.6 months, p = 0.041) and after two cycles of treatment (19.9 vs. 25.2 months, p = 0.018) tended to have a significantly shorter overall survival duration.
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- 2021
38. [Birth weights of singleton neonates of 14 Chinese ethnic groups in 11 cities of China]
- Author
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Xiao-Yun, Huang, Yuan-Fang, Zhu, Hui-Long, Liu, Mian-Ai, Fu, Chuan-Yong, Liu, Ding-Yuan, Zeng, Jun, He, Qing-Xi, Shi, Chang-Shui, Chen, Bin, Zhu, Gao-Xiong, Wang, Hao, Shi, and Hao-Hua, Lu
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Male ,China ,Clinical Research ,Infant, Newborn ,Ethnicity ,Humans ,Infant ,Birth Weight ,Gestational Age ,Cities ,Child - Abstract
OBJECTIVE: To develop the birth weight curves of the Chinese Han (26-41 weeks of gestation) and Zhuang (28-41 weeks of gestation) singleton neonates in 11 cities of China, as well as the birth weight means of full-term neonates of 14 Chinese ethnic groups. METHODS: The live singleton neonates who were born in 11 maternal and child health care hospitals from 11 cities of China between January 2017 and December 2020 were classified according to the mother's ethnic group. Birth weight means were calculated for the full-term neonates of each ethnic group. For the Han and Zhuang singleton neonates with a large sample size, the Lambda-Mu-Sigma (LMS) method was used to establish the birth weight percentile curves of the Han and Zhuang singleton neonates with different gestational ages. RESULTS: A total of 105 365 live singleton neonates were included, among whom the Han neonates had the highest number of 84 851 (26-41 weeks of gestation), followed by the Zhuang neonates (12 803 neonates with a gestational age of 28-41 weeks). The neonates of the other Chinese ethnic groups enrolled were live full-term singleton neonates, with a sample size of more than 100 neonates for each ethnic group. The 3rd-97th percentile curves of birth weight were established for the Han singleton neonates with a gestational age of 26-41 weeks and the Zhuang singleton neonates with a gestational age of 28-41 weeks. The birth weight curves of the Han singleton neonates at each gestational age were higher than those of the Zhuang singleton neonates. Birth weight means (3 199-3 499 g) and standard deviations were determined for 14 Chinese ethnic groups, i.e., Li, Mulao, Zhuang, Yao, Dong, Miao, Han, Buyi, Mongolian, Tujia, Yi, Hui, Man, and Korean ethnic groups. The Li ethnic group had the lowest birth weight, followed by the Mulao, Zhuang, Yao, Dong, Miao, Han, Buyi, Mongolian, Tujia, Yi, Hui, Man, and Korean ethnic groups. CONCLUSIONS: The 3rd-97th percentile curves of birth weight are developed for the Han (26-41 weeks of gestation) and Zhuang (28-41 weeks of gestation) singleton neonates in 11 cities of China, and birth weight means are determined for the full-term neonates of 14 Chinese ethnic groups in 11 cities of China, which provides a reference for evaluating the intrauterine growth of neonates in these ethnic groups.
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- 2022
39. Investigation of Dual Three-Phase 48-Slot/8-Pole Permanent Magnet Machines with Different Winding Arrangements
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Haoyu Chen, Hao Hua, and Wei Hua
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- 2022
40. Cupric Oxide Nanozymes for Biomedical Applications
- Author
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Shao-Bin He, Meng-Ting Lin, Hao-Hua Deng, and Wei Chen
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- 2022
41. Highly Efficient Luminescence from Charge-Transfer Gold Nanoclusters Enabled by Lewis Acid
- Author
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Kai-Yuan Huang, Ling-Fang Xiu, Xiang-Yu Fang, Ming-Rui Yang, Hamada A. A. Noreldeen, Wei Chen, and Hao-Hua Deng
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Luminescence ,Metal Nanoparticles ,General Materials Science ,Minocycline ,Gold ,Physical and Theoretical Chemistry ,Protons ,Scandium ,Lewis Acids - Abstract
Understanding the complicated intramolecular charge transfer (ICT) behaviors of nanomaterials is crucial to the development of high-quality nanoluminophores for various applications. However, the ICT process in molecule-like metal nanoclusters has been rarely explored. Herein, a proton binding-induced enhanced ICT state is discovered in 6-aza-2-thiothymine-protected gold nanoclusters (ATT-AuNCs). Such an excited-state electron transfer process gives rise to the weakened and red-shifted photoluminescence of these nanoclusters. By the joint use of this newfound ICT mechanism and a restriction of intramolecular motion (RIM) strategy, a red shift in the emission maxima of 30 nm with 27.5-fold higher fluorescence quantum efficiency is achieved after introducing rare-earth scandium ion (Sc
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- 2022
42. Protein-Assisted Osmium Nanoclusters with Intrinsic Peroxidase-like Activity and Extrinsic Antifouling Behavior
- Author
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Wei Chen, Hao-Hua Deng, Hua-Ping Peng, Meng-Ting Lin, Shao-Bin He, Hamada A.A. Noreldeen, and Liu Yang
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Materials science ,Metal Nanoparticles ,chemistry.chemical_element ,Catalysis ,Nanoclusters ,Metal ,Limit of Detection ,Animals ,General Materials Science ,Osmium ,Bovine serum albumin ,Detection limit ,biology ,Serum Albumin, Bovine ,Hydrogen Peroxide ,Combinatorial chemistry ,Linear range ,chemistry ,visual_art ,visual_art.visual_art_medium ,biology.protein ,Cattle ,Colorimetry ,Oxidation-Reduction ,Biomineralization - Abstract
Extensive studies have laid the groundwork for understanding peroxidase-like nanozymes. However, improvements are still required before their practical applications. On one hand, it is significant to explore highly reactive nanozymes. On the other hand, it is necessary to avoid fouling formed on the surface of nanozymes, which will affect their activity and the results of H2O2 sensors or H2O2-related applications. Herein, a strategy is reported to design osmium nanoclusters (Os NCs) with the existence of bovine serum albumin (BSA) through biomineralization. BSA-Os NCs were found to possess intrinsic peroxidase-like activity with a high specific activity (6120 U/g). Studies also found that the catalytic activity of BSA-Os NCs was better than those of reported protein-assisted metal nanozymes (e.g., BSA-Pt NPs and BSA-Au NCs). More significantly, BSA has been confirmed as a protective shell to give Os NCs extrinsic antifouling property in some typical ions (e.g., Hg2+, Ag+, Pb2+, I-, Cr6+, Cu2+, Ce3+, S2-, etc.), saline (0-2 M), or protein (0-100 mg/mL) conditions. Under optimal conditions, a colorimetric sensor was established to realize a linear range of H2O2 from 1.25 to 200 μM with a low detection limit of 300 nM. On this basis, remarkable features enable a BSA-Os NCs-based colorimetric sensor to detect H2O2 from complex systems with clear color gradients. Together, this work highlights the advantages of protein-assisted Os nanozymes and provides a paragon for peroxidase-like nanozymes in H2O2-related applications.
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- 2021
43. Accurate Deep CNN-Based Waveform Recognition for Intelligent Radar Systems
- Author
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Thien Huynh-The, Quoc-Viet Pham, Dong-Seong Kim, Cam-Hao Hua, and Van-Sang Doan
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Feature engineering ,business.industry ,Computer science ,Deep learning ,Feature extraction ,Communications system ,Computer Science Applications ,law.invention ,Computer engineering ,law ,Modeling and Simulation ,Scalability ,Feature (machine learning) ,Waveform ,Artificial intelligence ,Electrical and Electronic Engineering ,Radar ,business - Abstract
Nowadays radar systems have been facing with the disordered electromagnetic spectrum access and utilization in shared spectrum environments with radio communication systems. Numerous waveform recognition methods have been studied with feature engineering and conventional machine learning (ML) for intelligent radar systems, but they are critically challenged by practical problems of scalability and reliability. Deep learning (DL) with the ability to automatically learn the representational features is leveraged to handle the aforementioned obstacles effectively. In this work, we proposed a high-accurate waveform recognition method for intelligent radar systems by developing a novel residual-attention multiscale-accumulation convolutional network (RamNet). By deliberately incorporating the residual connection and attention connection in selective-feature improvement blocks, RamNet can enrich high-impact features without vanishing gradient. Moreover, a structural multiscale-accumulation connection is deployed to improve feature utilization by gathering the high-relevant features at multiple signal resolutions. Experimental results from exhaustive simulation demonstrate that RamNet recognizes waveform robustly under rigorous channel impairments and presents superior performance compared to traditional ML and state-of-the-art DL models.
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- 2021
44. The accuracy of patient-reported weight prior to total joint arthroplasty and arthroscopy of the lower extremity
- Author
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Linsen T. Samuel, Jason Silvestre, Alexander J. Acuña, Craig L. Israelite, Hao-Hua Wu, Charles L. Nelson, and Atul F. Kamath
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medicine.medical_specialty ,Joint arthroplasty ,medicine.diagnostic_test ,business.industry ,Arthroscopy ,General Medicine ,Zip code ,Mean difference ,Surgery ,Patient age ,Orthopedic surgery ,Medicine ,Orthopedics and Sports Medicine ,In patient ,business - Abstract
The accuracy of preoperative patient-reported weight was never evaluated in patients undergoing lower extremity procedures. The purpose of this study was to: (1) compare the disparity between patient-reported and measured weights in patients undergoing lower extremity total joint arthroplasty (LE-TJA) and arthroscopy; and (2) investigate the association between patient-specific factors (patient age, BMI, zip code, and psychiatric comorbidities) and the accuracy of patient-reported weight. Preoperative self-reported weights were retrospectively compared to measured weights in 400 LE-TJA and 85 control arthroscopy patients. The difference between reported and measured weights was calculated. Additionally, the percent of accurate reporting within 0.5, 1, and 5 kg ranges of the measured weight was calculated. Outcomes were compared between surgical modalities as well as between patient-specific factors. There was low disparity (p = 0.838) between patient-reported and measured weights among LE-TJA (mean difference 0.18 ± 3.63 kg; p = 0.446) and that of arthroscopy (0.27 ± 4.08 kg; p = 0.129) patients. Additionally, LE-TJA patients were equally likely to report weights accurately within 0.5 kg of the measured weight (74% vs. 71.76%; p = 0.908). LE-TJA and arthroscopy patients had similar reporting accuracy within 1 and 5 kg of the measured weights (p > 0.05). Preoperative patient-reported weights demonstrated acceptable accuracy in both LE-TJA and lower extremity arthroscopic orthopaedic patient populations making it a potentially reliable parameter of preoperative assessment.
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- 2021
45. Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasis
- Author
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Li-Zhen Zhang, Liang-Min Fu, Lei Tan, Yi-Hui Pan, Jinhuan Wei, Pengju Li, Wei Chen, Zhenhua Chen, Hao-Hua Yao, Junhang Luo, Guan-Nan Shu, Mingxiao Zhang, Jiaying Li, Jian-Ping Guo, Yiming Tang, Jun Lu, Zhuangyao Liao, and Zihao Feng
- Subjects
0301 basic medicine ,Cancer Research ,Carcinogenesis ,Biology ,medicine.disease_cause ,Article ,Metastasis ,Prognostic markers ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Genetics ,medicine ,Humans ,Enhancer ,Carcinoma, Renal Cell ,Molecular Biology ,Mechanism (biology) ,Ubiquitination ,medicine.disease ,Renal cell carcinoma ,Kidney Neoplasms ,Up-Regulation ,PVT1 ,Clear cell renal cell carcinoma ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,RNA, Long Noncoding ,Function (biology) - Abstract
Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal cell carcinoma (ccRCC). PVT1 is an important oncogenic lncRNA which has critical effects on onset and development of various cancers, however, the underlying mechanism of PVT1 functioning in ccRCC remains largely unknown. VHL deficiency-induced HIF2α accumulation is one of the major factors for ccRCC. Here, we identified the potential molecular mechanism of PVT1 in promoting ccRCC development by stabilizing HIF2α. PVT1 was significantly upregulated in ccRCC tissues and high PVT1 expression was associated with poor prognosis of ccRCC patients. Both gain-of-function and loss-of function experiments revealed that PVT1 enhanced ccRCC cells proliferation, migration, and invasion and induced tumor angiogenesis in vitro and in vivo. Mechanistically, PVT1 interacted with HIF2α protein and enhanced its stability by protecting it from ubiquitination-dependent degradation, thereby exerting its biological significance. Meanwhile, HIF2α bound to the enhancer of PVT1 to transactivate its expression. Furthermore, HIF2α specific inhibitor could repress PVT1 expression and its oncogenic functions. Therefore, our study demonstrates that the PVT1/ HIF2α positive feedback loop involves in tumorigenesis and progression of ccRCC, which may be exploited for anticancer therapy.
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- 2021
46. Convolutional Network With Twofold Feature Augmentation for Diabetic Retinopathy Recognition From Multi-Modal Images
- Author
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Sung-Ho Bae, Sungyoung Lee, Ki-Young Kim, Thuong Le-Tien, Thien Huynh-The, Seung-Young Yu, Cam-Hao Hua, and Jong In You
- Subjects
Fundus Oculi ,Computer science ,Feature vector ,Feature extraction ,02 engineering and technology ,Retina ,03 medical and health sciences ,Quadratic equation ,Health Information Management ,Robustness (computer science) ,Diabetes Mellitus ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Humans ,Electrical and Electronic Engineering ,030304 developmental biology ,0303 health sciences ,Diabetic Retinopathy ,Receiver operating characteristic ,business.industry ,Deep learning ,Angiography ,Pattern recognition ,Diabetic retinopathy ,medicine.disease ,Computer Science Applications ,Modal ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,Tomography, Optical Coherence ,Biotechnology - Abstract
Objective: With the scenario of limited labeled dataset, this paper introduces a deep learning-based approach that leverages Diabetic Retinopathy (DR) severity recognition performance using fundus images combined with wide-field swept-source optical coherence tomography angiography (SS-OCTA). Methods: The proposed architecture comprises a backbone convolutional network associated with a Twofold Feature Augmentation mechanism, namely TFA-Net. The former includes multiple convolution blocks extracting representational features at various scales. The latter is constructed in a two-stage manner, i.e., the utilization of weight-sharing convolution kernels and the deployment of a Reverse Cross-Attention (RCA) stream. Results: The proposed model achieves a Quadratic Weighted Kappa rate of 90.2% on the small-sized internal KHUMC dataset. The robustness of the RCA stream is also evaluated by the single-modal Messidor dataset, of which the obtained mean Accuracy (94.8%) and Area Under Receiver Operating Characteristic (99.4%) outperform those of the state-of-the-arts significantly. Conclusion: Utilizing a network strongly regularized at feature space to learn the amalgamation of different modalities is of proven effectiveness. Thanks to the widespread availability of multi-modal retinal imaging for each diabetes patient nowadays, such approach can reduce the heavy reliance on large quantity of labeled visual data. Significance: Our TFA-Net is able to coordinate hybrid information of fundus photos and wide-field SS-OCTA for exhaustively exploiting DR-oriented biomarkers. Moreover, the embedded feature-wise augmentation scheme can enrich generalization ability efficiently despite learning from small-scale labeled data.
- Published
- 2021
47. Cost utility analysis of intramedullary nailing and skeletal traction treatment for patients with femoral shaft fractures in Malawi
- Author
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Jan-Erik Gjertsen, David W. Shearer, Linda Chokotho, Sven Young, Brian C. Lau, Nyengo Mkandawire, Kiran J. Agarwal-Harding, Claire A. Donnelley, Geir Hallan, and Hao-Hua Wu
- Subjects
Adult ,Malawi ,endocrine system ,medicine.medical_specialty ,Femoral shaft ,Cost-Benefit Analysis ,medicine.medical_treatment ,Bone Nails ,law.invention ,Intramedullary rod ,03 medical and health sciences ,0302 clinical medicine ,Traction ,law ,Humans ,Medicine ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,health care economics and organizations ,Orthopedic surgery ,030222 orthopedics ,Traction Treatment ,Cost–utility analysis ,integumentary system ,business.industry ,General Medicine ,Traction (orthopedics) ,Fracture Fixation, Intramedullary ,Surgery ,body regions ,business ,Femoral Fractures ,RD701-811 ,Research Article - Abstract
Background and purpose — In Malawi, both skeletal traction (ST) and intramedullary nailing (IMN) are used in the treatment of femoral shaft fractures, ST being the mainstay treatment. Previous studies have found that IMN has improved outcomes and is less expensive than ST. However, no cost-effectiveness analyses have yet compared IMN and ST in Malawi. We report the results of a cost-utility analysis (CUA) comparing treatment using either IMN or ST. Patients and methods — This was an economic evaluation study, where a CUA was done using a decision-tree model from the government healthcare payer and societal perspectives with an 1-year time horizon. We obtained EQ-5D-3L utility scores and probabilities from a prospective observational study assessing quality of life and function in 187 adult patients with femoral shaft fractures treated with either IMN or ST. The patients were followed up at 6 weeks, and 3, 6, and 12 months post-injury. Quality adjusted life years (QALYs) were calculated from utility scores using the area under the curve method. Direct treatment costs were obtained from a prospective micro costing study. Indirect costs included patient lost productivity, patient transportation, meals, and childcare costs associated with hospital stay and follow-up visits. Multiple sensitivity analyses assessed model uncertainty. Results — Total treatment costs were higher for ST ($1,349) compared with IMN ($1,122). QALYs were lower for ST than IMN, 0.71 (95% confidence interval [CI] 0.66–0.76) and 0.77 (CI 0.71–0.82) respectively. Based on lower cost and higher utility, IMN was the dominant strategy. IMN remained dominant in 94% of simulations. IMN would be less cost-effective than ST at a total procedure cost exceeding $880 from the payer’s perspective, or $1,035 from the societal perspective. Interpretation — IMN was cost saving and more effective than ST in the treatment of adult femoral shaft fractures in Malawi, and may be an efficient use of limited healthcare resources. publishedVersion
- Published
- 2021
48. Multi-dimensional investigation and distribution characteristics analysis of gut microbiota of different marine fish in Fujian Province of China
- Author
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Sun, Hang, Chen, Fangyi, Hao, Hua, and Wang, Ke-Jian
- Subjects
Microbiology (medical) ,Microbiology - Abstract
The gut microbiota plays an important role in animal health and behavior. In marine fish, the composition of the gut microbiota is affected by many complex factors, such as diet, species, and regional factors. Since more than one hundred fish species have been cultured in fish farms along with the 3,324 km coastline of Fujian Province in South China, we chose this region to study the gut microbiota composition of marine commercial fishes because sufficient different species, diets, and regional factors were observed. We investigated the distribution characteristics of the gut microbiota of seven cultured species (Epinephelus akaara, Epinephelus coioides, Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀, Siganus fuscescens, Pagrus major, Lateolabrax japonicus, and Acanthopagrus schlegelii) living in the same aquatic region and one species (E. akaara) living separately in five regions separated by latitude. The impacts of diet, region, and species factors on fish gut microbiota were also evaluated. Diversity and multivariate analyses showed that the patterns of the microbiota were significantly different in different fish species within the same habitat and E. akaara with five latitude regions. Mantel analysis showed that AN, SiO32–, DO, and NO2– were the principal factors affecting the microbial community of E. akaara in the five habitats. Additionally, similar distribution characteristics occurred in different gut parts of different fishes, with an increasing trend of Proteobacteria and Vibrionaceae abundance and a decreasing trend of Firmicutes and Bacillaceae abundance from the foregut to the hindgut. Vibrionaceae was the most abundant family in the content. This study highlights that a persistent core microbiota was established in marine commercial fishes spanning multiple scales. The factors with the greatest effect on fish gut microbiota may be (i) host genetics and (ii) geographic factors rather than the microbiota in the diet and water environment. These core microbes regularly colonized from the foregut to the hindgut, which was driven by their underlying functions, and they were well adapted to the gut environment. Moreover, the microbiota in the content may have contributed more to the gut microbial communities than previously reported. This study could complement basic data on the composition of marine commercial fishes and facilitate relatively complete investigations, which would be beneficial for the healthy and sustainable development of aquaculture.
- Published
- 2022
49. 3- to 24-month Follow-up on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge: Results from a Prospective, Multicenter Study
- Author
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Jing Ya, Wang, Xing Yu, Zong, Gui Hui, Wu, Yuan Lin, Qi, Hui Zhen, Li, Xin Yu, Ji, Lin, Tong, Lei, Zhang, Ming Bo, Yang, Pu Ye, Yang, Ji Ke, Li, Fu Rong, Xiao, Lin Song, Zhang, Yun Hong, Hu, Hong De, Liu, Shou Fang, Xu, Sheng, Sun, Wei, Wu, Ya, Mao, Min Qing, Li, Hao Hua, Hou, Zhao Yuan, Gong, Yang, Guo, Li Wen, Jiao, Jin, Qin, Ding Yi, Wang, Fang, Wang, Li, Guan, Gang, Lin, Yan, Ma, Yan Ping, Wang, and Nan Nan, Shi
- Subjects
Male ,Humans ,COVID-19 ,Female ,Prospective Studies ,Survivors ,Middle Aged ,Tuberculosis, Pulmonary ,Follow-Up Studies - Abstract
Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are major public health and social issues worldwide. The long-term follow-up of COVID-19 with pulmonary TB (PTB) survivors after discharge is unclear. This study aimed to comprehensively describe clinical outcomes, including sequela and recurrence at 3, 12, and 24 months after discharge, among COVID-19 with PTB survivors.From January 22, 2020 to May 6, 2022, with a follow-up by August 26, 2022, a prospective, multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in China. Clinical outcomes, including sequela, recurrence of COVID-19, and PTB survivors, were collectedThirty-two COVID-19 with PTB survivors were included. The median age was 52 (45, 59) years, and 23 (71.9%) were men. Among them, nearly two-thirds (62.5%) of the survivors were moderate, three (9.4%) were severe, and more than half (59.4%) had at least one comorbidity (PTB excluded). The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6% at 3 months to 15.8% at 24 months, with anxiety having a higher proportion over a follow-up. Cough and amnesia recovered at the 12-month follow-up, while anxiety, fatigue, and trouble sleeping remained after 24 months. Additionally, one (3.1%) case presented two recurrences of PTB and no re-positive COVID-19 during the follow-up period.The proportion of long symptoms in COVID-19 with PTB survivors decreased over time, while nearly one in six still experience persistent symptoms with a higher proportion of anxiety. The recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention.
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- 2022
50. A magnetically recyclable lignin-based bio-adsorbent for efficient removal of Congo red from aqueous solution
- Author
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Enmin Zong, Runfang Fan, Hao Hua, Jiayao Yang, Shengtao Jiang, Jinfeng Dai, Xiaohuan Liu, and Pingan Song
- Subjects
Structural Biology ,General Medicine ,Molecular Biology ,Biochemistry - Abstract
It has been always attractive to design a sustainable bio-derived adsorbent based on industrial waste lignin for removing organic dyes from water. However, existing adsorbent strategies often lead to the difficulties in adsorbent separation and recycling. Herein, we report a novel magnetically recyclable bio-adsorbent of Mg(OH)
- Published
- 2022
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