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3 results on '"Hanna GG"'

1. CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer

Author

Walls, GM, Oughton, JB, Chalmers, AJ, Brown, S, Collinson, F, Forster, MD, Franks, KN, Gilbert, A, Hanna, GG, Hannaway, N, Harrow, S, Hinsley, S, Murden, G, Phillip, R, Anderson, RJ, Salem, A, Sebag-Montefoire, D, Shaw, P, Twelves, CJ, Walker, K, Young, RJ, Faivre-Finn, C, and Greystoke, A

Abstract

Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for ‘gold standard’ treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multiple novel radiosensitisers targeting DNA repair proteins in patients treated with sequential chemoradiotherapy. Time-to-event continual reassessment will facilitate efficient dose-finding. Abbreviations ATM: Ataxia telangiectasia mutated ATR: Ataxia telangiectasia and Rad3 related cfDNA: Cell-free DNA CRT: Chemoradiotherapy CT: Computed tomography CTCAE: Common terminology criteria for adverse events CTRad: Clinical and Translational Radiotherapy Research Working Group DDRi: DNA damage response inhibitor DLT: Dose limiting toxicity DNA: Deoxyribonucleic acid DNA-PK: DNA-dependent protein kinase ECOG: Eastern Cooperative Oncology Group EORTC: European Organisation for Research and Treatment of Cancer ICRU: International Commission on Radiation Units and Measurements IMPs: Investigational medicinal products LA: Locally advanced MRC: Medical Research Council NCRI: National Cancer Research Institute NSCLC: Non-small cell lung cancer PARP: Poly (ADP-ribose) polymerase PET: Positron emission tomography PFS: Progression free survival PROMs: Patient-reported outcome measures RECIST: Response evaluation criteria in solid tumours RP2D: Recommended phase II dose RT: Radiotherapy SACT: Systemic anti-cancer therapy SRC: Safety review committee TiTE-CRM: Time to event continual reassessment method TNM: Tumour node metastasis

Published
2020

3. Heart fatty acid binding protein (H-FABP) in combination with the 80-lead body surface map (BSM) improves early detection of acute myocardial infarction

Author

Hoeritzauer, AI, Bradley, J, Rendall, J, Hall, V, Goldsmith, C, Moore, J, Elborn, S, Daly, MJ, McCann, CJ, Owens, CG, Stevenson, S, Young, IS, Adgey, AAJ, Carser, JE, Quinn, JE, McCluggage, WG, Maxwell, P, Lioe, TF, Mullan, PB, Gourley, C, Harkin, DP, Connolly, M, Toner, P, Laverty, L, McGrath, P, Connolly, D, McCluskey, DR, Loughins, L, Hamilton, PK, McCann, A, Agnew, C, McGivern, RC, McVeigh, GE, Jones, C, Badger, SA, Boyd, CS, Soong, CV, Badger, S, McCoubrey, A, McKie, L, Taylor, M, Diamond, T, Lynch, T, Turkington, R, Allen, W, Stevenson, L, Coyle, V, Jithesh, P, Proutski, I, Fenning, C, Stewart, G, Longley, D, Johnston, P, Fitzmaurice, GJ, Mone, F, Brown, R, Cranley, B, Conlon, EF, Todd, RAJ, O'Donnell, ME, McKinley, JJ, Carr, AS, McKee, S, Morrison, P, Forbes, RB, McDonnell, GV, Cardwell, C, O'Reilly, D, McCarron, P, McConville, J, Wallace, IR, Hunter, SJ, Koehler, K, Huebner, A, Carson, D, Crawford, AM, McConville, C, Cuthbert, RJG, McMullin, MF, O'Neill, S, 0'Donnell, ME, George, R, Wallace, W, Harkin, DW, Lee, B, Blair, PH, Goody, RB, Calderwood, J, Choong, ES, Law, SJM, Mazdai, G, McAleer, JJA, Hanna, GG, McAree, B, Spence, A, McManus, DT, Spence, RAJ, McGreevy, A, Millar, L, Murphy, B, and Davison, GW

Subjects
Poster Presentations, Abstracts, Platform Presentations, Abstract
Published
2010

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