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102 results on '"Gusarova, Nina K."'

1. Synthesis of Non-Symmetric Functionalized Polyfluoroalkyl Phosphites

Author

Svetlana N. Arbuzova, Lyudmila A. Oparina, Natal’ya A. Belogorlova, Svetlana F. Malysheva, Trofimov Boris A, Gusarova Nina K, A. M. Nalibayeva, N. A. Chernysheva, G. K. Bishimbayeva, S. V. Yas’ko, and S. I. Verkhoturova

Subjects
chemistry.chemical_classification, Tris, 010405 organic chemistry, Aryl, Non symmetric, General Chemistry, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Yield (chemistry), Allyl alcohol, Inert gas, Triethylamine, Alkyl
Abstract

Two ways for the synthesis of new representatives of non-symmetric organic phosphites with polyfluoroalkyl substituents were developed based on organic dichlorophosphites. The reaction of polyfluoroalkyl dichlorophosphites with allyl alcohol, proceeding at a temperature of –10–22°C (2 h) in the presence of triethylamine, gave diallyl polyfluoroalkyl phosphites in a yield of 75–77%. Under similar conditions (–30–22°C, 2–4 h, Et3N), alkyl (or aryl) dichlorophosphites reacted with polyfluoroalkanols to form alkyl (or aryl) bis(polyfluoroalkyl) phosphites (yield 56–67%). Unlike diallylpolyfluoroalkyl- and alkylbis(polyfluoroalkyl) phosphites, arylbis(polyfluoroalkyl) phosphites are symmetrized under storage conditions (room temperature, inert atmosphere), forming the corresponding triaryl- and tris(polyfluoroalkyl) phosphites.

Published
2020

2. Synthesis and antimicrobial activity of new phosphorus-containing pyridine derivatives

Author

Nina I. Ivanova, Lyudmila A. Belovezhets, Gusarova Nina K, K. A. Apartsin, Anton A. Telezhkin, Ksenia O. Khrapova, Pavel A. Volkov, and Viktoriya V. Kireeva

Subjects
chemistry.chemical_compound, Environmental Engineering, chemistry, Phosphorus containing, Pyridine, Organic chemistry, Antimicrobial, Industrial and Manufacturing Engineering
Abstract

The directed synthesis of new pharmacophoric molecules is one of the urgent tasks of organic chemistry. A special place in this area is occupied by vital nitrogen-containing heterocycles and their derivatives, on the basis of which new promising precursors of drugs are created. For example, pyridinium salts are part of such well-known drugs as pyridoxine, mexidol and metadoxine. Phosphorus-containing pyridine derivatives, among which compounds with cytotoxic and antimicrobial properties have been identified, are also being actively studied now. Thus, the development of convenient approaches for obtaining new functional phosphorus-containing pyridine derivatives is an important and timely task. Special attention is paid to synthetic methods that correspond to the PASE (pot, atom and step economy) paradigm. Using this approach, we have synthesized hydrochlorides and tosylates of 4-bis(2-phenylethyl)chalcogenophosphoryl-pyridine, not described previously, by practically quantitative interaction of the available 4-bis(2-phenylethyl)chalcogenophosphorylpyridines with hydrochloric or 4-methylbenzenesulfonic acids at room temperature or slight heating (40-45 °C). The reaction proceeds regioselectively on the nitrogen atom of the base pyridine. The second reaction center in the 4-bis(2-phenylethyl)chalcogenophosphorylpyridine molecule, chalcogenophosphoryl group, does not participate in the studied process, even when using an excess of hydrochloric acid. The starting 4-bis(2-phenylethyl)chalcogenophosphorylpyridines are easily obtained on the basis of the original reaction of pyridine with secondary phosphine chalcogenides with the assistance of electron-deficient acetylenes. Using the example of microorganisms of different taxonomic groups: Bacillus subtilis B-406, Enterococcus durans B-603, Penicillium citreo-viride F-1777, Escherichia coli B-1238, we have found that the target hydrochlorides and tosylates of 4-bis(2-phenylethyl)chalcogenophosphorylpyridine exhibit pronounced antimicrobial activity against non-spore gram-positive microorganisms.

Published
2019

3. PERSPECTIVE SULFUR-CONTAINING ORGANOPHOSPHORUS EXTRACTANTS OF HEAVY METALS

Author

Erlan Abdikalykov, Araylym Nalibaeva, Gauhar Bishimbaeva, Asem Zhanabaeva, Trofimov Boris A, Gusarova Nina K, and Svetlana Verhoturova

Subjects
Chemistry, Environmental chemistry, Perspective (graphical), Heavy metals, Sulfur containing
Abstract

The possibility and prospects of using tertiary phosphine sulfides synthesized on the basis of on affordable and secondary raw materials as effective extractants of heavy metals have been investigated

Published
2021

4. AN ENVIRONMENTALLY BENIGN ATOM-ECONOMIC SYNTHESIS OF METHYL-2-PROPENYL ETHER

Author

Lyudmila A. Oparina, Trofimov Boris A, Gusarova Nina K, M.Ya. Khil’ko, and Lidiya N. Parshina

Subjects
Pulmonary and Respiratory Medicine, Propenyl, chemistry.chemical_compound, chemistry, Pediatrics, Perinatology and Child Health, Atom (order theory), Ether, Medicinal chemistry
Published
2016

5. Reaction of imidazole series aldeydes with bis[2-(2-pyridyl)ethyl]-phosphine chalcogenides: Synthesis of polyfunctional heterocyclic systems

Author

Trofimov Boris A, Gusarova Nina K, L. V. Baikalova, Nina I. Ivanova, and Pavel A. Volkov

Subjects
chemistry.chemical_classification, Benzimidazole, Nucleophilic addition, Sulfide, Chemistry, Organic Chemistry, Medicinal chemistry, Catalysis, chemistry.chemical_compound, Selenide, Pyridine, Imidazole, Organic chemistry, Phosphine
Abstract

The nucleophilic addition of bis[2-(2-pyridyl)ethyl]phosphine sulfide and bis[2-(2-pyridyl)-ethyl]phosphine selenide to 2-formyl-1-organylimidazoles and benzimidazoles occurs efficiently without catalysis at room temperature to give functionalized heterocyclic compounds containing imidazole, benzimidazole, and pyridine rings and also chalcogenophosphoryl and hydroxyl groups.

Published
2008

6. Catalytic oxidation of organic substrates with hydrogen peroxide in two-phase systems in the presence of peroxo-polyoxotungstates containing organic ligands

Author

T. B. Khlebnikova, Trofimov Boris A, Gusarova Nina K, A. G. Tolstikov, P. V. Berdnikova, O. N. Roor, Zinaida P. Pai, Nina I. Ivanova, and Svetlana F. Malysheva

Subjects
chemistry.chemical_compound, chemistry, Catalytic oxidation, Benzyl alcohol, Cyclooctene, Phase (matter), Organic chemistry, Physical and Theoretical Chemistry, Hydrogen peroxide, Bifunctional, Catalysis, Phosphine
Abstract

The prospects of using bifunctional homogeneous metal-complex catalysts based on peroxo-polyoxotungstates with organic ligands (tertiary phosphine oxides) were exemplified by oxidation of benzyl alcohol and cyclooctene with hydrogen peroxide in two-phase systems (organic phase — liquid phase).

Published
2008

7. Atom-Economic Synthesis of New Imidazoles and Benzimidazoles with Thiophosphoryl and Hydroxyl Groups

Author

Tatarinova Anna A, A. I. Albanov, Nina I. Ivanova, Lidiya M. Sinegovskaya, Boris G. Sukhov, Trofimov Boris A, Gusarova Nina K, N. A. Konovalova, V. A. Kukhareva, L. V. Baikalova, N. D. Avseenko, and I. A. Zyryanova

Subjects
chemistry.chemical_classification, Denticity, Nucleophilic addition, Organic Chemistry, Aldehyde, Metal, chemistry.chemical_compound, chemistry, visual_art, Yield (chemistry), Polymer chemistry, visual_art.visual_art_medium, Azole, Organic synthesis, Phosphine
Abstract

Nucleophilic addition of secondary phosphine sulfides to an aldehyde of the azole series occurs under noncatalytic conditions in THF at room temperature and enables the preparation in high yield of imidazoles and benzimidazoles with thiophosphoryl and hydroxyl groups, which are promising building blocks for organic synthesis and polydentate ligands for metal complexes.

Published
2005

9. Reaction of 3-thiolene 1,1-dioxide with PH-acids

Author

Lyudmila I. Larina, Svetlana F. Malysheva, Trofimov Boris A, Gusarova Nina K, Nina I. Ivanova, Natal’ya A. Belogorlova, and M. Ya. Khil'ko

Subjects
Phosphine oxide, chemistry.chemical_compound, Nucleophilic addition, Chemistry, Organic Chemistry, Organic chemistry, Medicinal chemistry, Catalysis
Abstract

The nucleophilic addition of 2-phenylethylphosphine, bis(2-phenylethyl)phosphine oxide, and bis(2-phenylpropyl)phosphine oxide to 3-thiolene 1,1-dioxide catalyzed by the KOH-DMSO system leads to bis(3-thioanil) (2-phenylethyl)phosphine oxide, bis(2-phenylethyl) (3-thianil)phosphine oxide, and bis(2-phenylpropyl) (3-thioanil)phosphine oxide, respectively.

Published
1998

10. ChemInform Abstract: Nucleophilic Addition to Acetylenes in Superbasic Catalytic Systems. Part 17. Vinyl Ethers with Furyl and Cycloacetal Fragments: Synthesis and Structure

Author

Kirill A. Chernyshev, Anton V. Stepanov, Lyudmila A. Oparina, Leonid B. Krivdin, Trofimov Boris A, Gusarova Nina K, and Oksana V. Vysotskaya

Subjects
chemistry.chemical_compound, Nucleophilic addition, integumentary system, Acetylene, Chemistry, Yield (chemistry), Glycerol, Organic chemistry, General Medicine, Furfural, Catalysis
Abstract

The reaction of furfural with glycerol leads to a mixture of alcohols (II) and (III), which reacts readily with acetylene to afford a mixture of corresponding vinyl ethers in high yield.

Published
2011

16. ChemInform Abstract: Synthesis of Tris(2,2-dialkoxyethyl)phosphine Oxides from Red Phosphorus and 1,1-Dialkoxy-2-bromoethane in Superbase Systems

Author

V. I. Dmitriev, Lyudmila A. Oparina, Trofimov Boris A, Gusarova Nina K, Svetlana F. Malysheva, M. G. Voronkov, S. I. Shiakhudinova, and T. N. Rakhmatulina

Subjects
Tris, chemistry.chemical_compound, chemistry, Phosphorus, Superbase, Inorganic chemistry, chemistry.chemical_element, Organic chemistry, General Medicine, Bromoethane, Phosphine
Published
2010

21. ChemInform Abstract: Reactions of Red Phosphorus with Electrophiles in Superbasic Systems. Part 6. Identification of the Products of Phosphorylation of Phenylacetylene with the System P-KOH-HMPA Under Conditions of Mechano- Chemical Activation

Author

S. V. Zinchenko, Svetlana N. Arbuzova, V. I. Dmitriev, T. N. Rakhmatulina, Trofimov Boris A, Gusarova Nina K, S. I. Shaikhudinova, and Svetlana F. Malysheva

Subjects
chemistry.chemical_compound, Phenylacetylene, chemistry, Phosphorus, Electrophile, chemistry.chemical_element, Organic chemistry, Phosphorylation, General Medicine
Published
2010

39. ChemInform Abstract: Vinyl Ethers Containing Isothiocyanate Group. Part 15. Reaction of 2-(Vinyloxy)ethyl Isothiocyanate with Bis(2-phenylethyl)phosphine and Bis(2-phenylethyl)phosphine Oxide

Author

Svetlana F. Malysheva, V. P. Zinov'eva, Natal’ya A. Belogorlova, G. I. Sarapulova, Trofimov Boris A, Gusarova Nina K, L. A. Klyba, Nina A. Nedolya, L. Brandsma, and A. I. Albanov

Subjects
Phosphine oxide, chemistry.chemical_compound, chemistry, Group (periodic table), Isothiocyanate, Organic chemistry, General Medicine, Medicinal chemistry, Phosphine
Published
2010

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