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Your search keyword '"Gurung, Resham L."' showing total 3 results
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3 results on '"Gurung, Resham L."'

2. Supplementary_Materials__R2 – Supplemental material for Cause-Specific Mortality in Multiethnic South East Asians With Type 2 Diabetes Mellitus

Author

Liu, Jian-Jun, Choo, Robin W. M., Liu, Sylvia, Gurung, Resham L., Shiou Liang Wee, and Lim, Su Chi

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, Supplementary_Materials__R2 for Cause-Specific Mortality in Multiethnic South East Asians With Type 2 Diabetes Mellitus by Jian-Jun Liu, Robin W. M. Choo, Sylvia Liu, Resham L. Gurung, Shiou Liang Wee and Su Chi Lim in Asia Pacific Journal of Public Health

Published
2019
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3. Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association

Author

Garg, Mansi, Gurung, Resham L, Mansoubi, Sahar, Ahmed, Jubed O, Davé, Anoushka, Watts, Felicity Z, and Bianchi, Alessandro

Subjects
Molecular Sequence Data, SUMO-1 Protein, Telomere-Binding Proteins, genetic processes, Shelterin Complex, Evolution, Molecular, Schizosaccharomyces, Amino Acid Sequence, Telomerase, CST, QD0415, Tpz1, Scientific Reports, fungi, Sumoylation, Telomere Homeostasis, Telomere, telomeres, DNA-Binding Proteins, enzymes and coenzymes (carbohydrates), Stn1, SUMO, Schizosaccharomyces pombe Proteins, Carrier Proteins, human activities, Protein Binding
Abstract

Elongation of the telomeric overhang by telomerase is counteracted by synthesis of the complementary strand by the CST complex, CTC1(Cdc13)/Stn1/Ten1. Interaction of budding yeast Stn1 with overhang-binding Cdc13 is increased by Cdc13\ud SUMOylation. Human and fission yeast CST instead interact with overhang-binding TPP1/POT1. We show that the fission yeast TPP1 ortholog, Tpz1, is SUMOylated. Tpz1 SUMOylation restricts telomere elongation and promotes Stn1/Ten1 telomere association,and a SUMO-Tpz1 fusion protein has increased affinity for Stn1. Our data suggest that SUMO inhibits telomerase through stimulation of Stn1/Ten1 action by Tpz1, highlighting the evolutionary conservation of the regulation of CST function by SUMOylation.

Published
2014

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