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Four kinds of industrial solid waste, granulated blast furnace slag (GBFS), electric furnace steel slag (EFSS), semi-dry flue gas desulfurization slag (FGDS) and gypsum were activated by mechanochemistry to prepare a novel kind of cementious material, DA type soil solidification agent (DA agent). Compared to the traditional cementious materials, this paper evaluated DA agent used in silt soil solidification project. Test results showed that DA-4 was prepared with adding the 40% CFBA, 39% GBFS, 11% OPC clinker and 10% gypsum by mill and more superior in material characteristics. It was found that compressive strength of DA-4 paste and mortar specimens at 28-days cured age were 46.0 and 27.3 MPa respectively; 5% of DA-4 was used to stabilize the silt soil in lab and the maximum dry unit weight, optimum moisture content, unconfined compressive strength and CBR value were 1.754 g/cm3, 15.35%, 1.15 MPa and 95.5% respectively. The hardening mechanism of prepared cementious materials is explained by two points: the sulfite or sulfate activation on alkali blast furnace slag; and the hydration product produced from cement clinker hydration process. Besides test programs of the trial pavement section in site showed that stabilized and solidified silt soils by DA-4 can meet the requirement of subgrade of pavement for strength and stiffness.

The effect of vitamin D pertinent to cardiovascular health on the heart itself is considered to shift toward an anti-inflammatory response in chronic heart failure (CHF); however, its underlying mechanism is not completely understood. In this study, we demonstrated that plasma 25(OH)D level, negatively associated with NT-ProBNP, correlated with the decreased Treg in CHF compared to the patients with other cardiovascular diseases and healthy and older donors. Naïve Treg cell (CD4(+)CD45RA(+)Foxp3(lo)T) subset, rather than whole Treg cells, contributes to the reduction of Treg in CHF. 1,25(OH)2D treatment maintained partial expression of CD45RA on CD4(+)T cell after αCD3/CD28 monoclonal antibodies activation and ameliorated the impaired CD4(+)CD45RA(+)T cell function from CHF patients through upregulating Foxp3 expression and IL-10 secretion in vitro. Low level of vitamin D receptor (VDR) was detected in CD4(+)CD45RA(+)T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell. The results of this study might provide tangible evidence to our knowledge of the impact of vitamin D supplementation on naïve Tregs, which may offer new means of preventing and treating CHF.