1. Effect of Helicobacter pylori eradication therapy in iron deficiency anaemia of pregnancy – A pilot study
- Author
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Malik, Ria, Guleria, Kiran, Kaur, Iqbal, Sikka, Meera, and Radhakrishnan, Gita
- Subjects
Adult ,Helicobacter pylori ,Adolescent ,Anemia, Iron-Deficiency ,iron deficiency anaemia ,Amoxicillin ,Pilot Projects ,Eradication therapy ,Anti-Bacterial Agents ,Helicobacter Infections ,Pregnancy Complications ,Folic Acid ,Double-Blind Method ,Pregnancy ,Clarithromycin ,Humans ,Original Article ,Drug Therapy, Combination ,Female ,Disease Eradication ,Iron, Dietary ,Omeprazole - Abstract
Background & objectives: Despite routine iron supplementation and promotion of diet modification, iron deficiency anaemia (IDA) remains widely prevalent in our antenatal population. Recent studies in pediatric population have highlighted the role of Helicobacter pylori infection in IDA. This study was undertaken to study the effect of eradication therapy in H. pylori infected pregnant women with IDA. Methods: Randomized placebo-controlled double blind clinical trial was done on 40 antenatal women between 14-30 wk gestation, with mild to moderate IDA and having H. pylori infection, as detected by stool antigen test. These women were randomly divided into group I (n=20): H. pylori treatment group (amoxicillin, clarithromycin, omeprazole for 2 wk) and group II (n=20): placebo group. Both groups received therapeutic doses of iron and folic acid. Outcome measures were improvement in haematological parameters and serum iron profile after 6 wk of oral iron therapy. Results: The prevalence of iron deficiency in pregnant women with mild to moderate anaemia was 39.8 per cent (95% CI 35.7, 44.3); and 62.5 per cent (95% CI 52, 73) of these pregnant women with IDA were infected with H. pylori. After 6 wk of therapeutic oral iron and folic acid supplementation, the rise in haemoglobin, packed cell volume, serum iron and percentage transferrin saturation was significantly (P
- Published
- 2011