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1. Ética, política y corrupción: Una revisión conceptual enfatizada en Perú

Author: Pérez Guevara, L., Zárate Tacca, W. R., Antón de los Santos, M. A., and olgado Quispe, A. M.
Abstract: En el presente artículo se realiza una revisión de distintas fuentes bibliográficas que tienen como variables de investigación la ética, política y corrupción haciendo énfasis en la realidad peruana. El principal objetivo del artículo es analizar las diversas definiciones que tienen las variables mencionadas, según diferentes autores y sus respectivas realidades políticas, además una gran parte de las fuentes pertenecen a la realidad peruana, cuya política resulta bastante voluble, retadora y problemática. Para la presente revisión se seleccionaron 20 artículos extraídos de Scopus y relacionados a las variables de investigación. Como resultados se obtuvieron conceptos asociados a la ética, política y corrupción, desde los puntos de vista teológico, psicológico y cultural, además, se resaltaron los aportes más importantes, que buscan ayudar a entender el origen de la corrupción en la política y las medidas que se pueden llevar a cabo para empoderar la lucha contra ésta. Por último, se desplegó un breve resumen sobre la realidad política peruana y la corrupción inherente a esta. Se concluye en la importancia del estudio ético dentro de la política, representando un gran aporte para futuros investigadores de la realidad nacional a través de los años y el boom de la corrupción en Perú.
Published: 2022

2. Electrical resistivity structure in the Tocomar geothermal system obtained from 3-D inversion of audio-magnetotelluric data (Central Puna, NW Argentina)

Author: Ahumada, MF, Guevara, L, Favetto, A, Filipovich, R, Chiodi, A, Viramonte, JG, Giordano, G, Ahumada, Mf, Guevara, L, Favetto, A, Filipovich, R, Chiodi, A, Viramonte, Jg, and Giordano, G
Subjects: Electromagnetic method, Renewable energy, Central Andean Volcanic Zone, Renewable Energy, Sustainability and the Environment, Geophysical exploration, Geothermal field, Puna, Geology, Geotechnical Engineering and Engineering Geology
Abstract: The Tocomar Geothermal System is located in the Puna Plateau (NW Argentina), within the Central Puna Energy Hub, and is considered one of the most promising places to harness potential alternative of power and heat sources in the Central Andean Volcanic Zone (16-28 degrees S). It is related to the Calama-Olacapato-Toro lineament and to the Quaternary Tocomar volcanic centre. Moreover, it is surrounded by active and fossil geothermal manifestations, like hot-springs, travertines and siliceous sinter deposits. Despite some geological studies in the area, no geophysical investigations have targeted the geothermal fields along the Central Puna.In this work we present a 3-D inversion of audio-magnetotelluric data around the Tocomar Geothermal System. These data was obtained in the frequency range of 1000-0.1 Hz to map the main elements of the geothermal system (clay cap and potential reservoir) at depths of approximately 1000 m. To achieve this goal, previous geoelectrical studies, the local geology and the trend of the main structures were also considered. For the 3-D inversion process the ModEM code was used.The model shows a low-resistivity layer (less than 10 Omega m) at least 300 m thick, at a depth of about 200-500 m, aligned with both the strike of the Calama-Olacapato-Toro lineament and the local superficial geothermal manifestations (hot-springs and hydrothermally altered rocks). This low-resistivity layer is linked with the clay cap at the shallow depth of the geothermal reservoir. At depths greater than 800 m, a gradual increase in resistivity is observed related to a potential reservoir within the fractured Ordovician basement. The final 3-D resistivity model highly correlates with the conceptual models of high-temperature volcanic geothermal systems.
Published: 2022
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3. Nitric oxide stimulates the synthesis of compounds with potential therapeutic uses in sweet pepper (Capsicum annuum L.)

Author: González-Gordo, Salvador, Guevara, L., Díaz, C., Pérez del Palacio, J., Vicente, F., Corpas, Francisco J., Palma Martínez, José Manuel, Ministerio de Ciencia e Innovación (España), and Junta de Andalucía
Abstract: Resumen de la comunicación oral presentada en: 8th Plant Nitric Oxide International Meeting. Celebrado en Hungria Szeged. 7-9 Julio 2022, Financed by grants PlD20l9-103924GB-loo (MICIN) and P18-FR-1359 (Junta de Andalucía), Spain]
Published: 2021

4. CFD Modeling and evaluation of a bi-stable micro-diverter valve

Author: Marco A Guevara L and Luis C Belalcazar C
Subjects: Physics, 0209 industrial biotechnology, Renewable Energy, Sustainability and the Environment, General Chemical Engineering, Geology, 02 engineering and technology, 021001 nanoscience & nanotechnology, 020901 industrial engineering & automation, General Energy, Geophysics, Fuel Technology, Bi stable, 0210 nano-technology, Engineering (miscellaneous), Humanities
Abstract: espanolRESUMEN Las valvulas de micro- desviacion son dispositivos innovadores y eficientes que se utilizan para generar microburbujas que pueden mejorar significativamente la eficiencia de un proceso en la industria. Las valvulas de microdesviacion han sido probadas experimentalmente y modeladas usando CFD en trabajos previos. Sin embargo, hasta el momento no se habia llevado a cabo una evaluacion del modelado en CFD de estas valvulas utilizando un modelo detallado de turbulencia en estado transitorio y estable. Este articulo presenta una simulacion tridimensional de CFD y la evaluacion del rendimiento de una valvula desviada biestable para la generacion de microburbujas. En el modelo, fueron utilizados aproximaciones en estado estable y transitorio para cuantificar el desempeno de la valvula. Los modelos k - e estandar y de turbulencia k - e RNG fueron utilizados y comparados. Fueron evaluados diferentes metodos de generacion y configuraciones de malla y ambos modelos de turbulencia para encontrar la mejor configuracion para simular esta valvula. Ademas se realizo un breve analisis del tamano del paso de tiempo utilizando el enfoque del numero Courant. Fueron evaluadas las condiciones de operacion a bajo Reynolds (3800) y alta frecuencia (200 Hz) para posibles aplicaciones industriales, sentando asi la base para estudios posteriores. Los resultados de este trabajo muestran que a bajos numeros de Reynolds y altas frecuencias, la valvula puede desviar el fluido y, por lo consiguiente puede servir en una amplia cantidad de aplicaciones industriales. EnglishABSTRACT Micro-diverter valves are innovative and efficient devices used to generate microbubbles that can significantly enhance process efficiency in industry. Micro-diverter valves have been experimentally tested and modeled using CFD in previous works. However, a detailed CFD modeling evaluation of these valves has not been performed employing detailed turbulence modeling at transient and steady state. This article presents a three-dimensional CFD simulation and performance evaluation of a bi-stable diverted valve for microbubble generation. In the model, transient and steady state approaches were used to quantify the behavior in the valve. The K - e standard and k - e RNG turbulence models were used and compared. Different mesh configurations, mesh generation methods, and both turbulence models were evaluated to find the best set-up to simulate this valve. A brief analysis of the time-step size using the Courant number approach was also performed. Operation conditions at low Reynolds (3800) and high frequency (200 Hz) were used to assess possible industrial applications, thus setting the base for further studies. The results of this work show that at low Reynolds numbers and high frequencies, the valve is able to divert the fluid and thus it may have wider industrial applications.
Published: 2018
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5. A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees

Author: Strong, V, Möller, T, Tillman, A-S, Träff, S, Guevara, L, Martin, M, Redrobe, S, and White, K
Abstract: Objective: To characterise the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and their suitability for the immobilisation of healthy chimpanzees undergoing cardiac assessment.\ud \ud Study design: Prospective, clinical, longitudinal study\ud \ud Animals: Six chimpanzees (Pan troglodytes) aged 4 - 16 years weighing 19.5 - 78.5 kg were anaesthetized on two occasions\ud \ud Methods: Anaesthesia was induced with tiletamine/zolazepam (TZ) (3-4 mg kg-1) or tiletamine/zolazepam (2 mg kg-1) and medetomidine (0.02 mg kg-1) (TZM) via blow dart (IM) and maintained with intermittent boluses of ketamine (IV) or zolazepam/tiletamine (IM) as required. The overall quality of the anaesthesia was quantified based on scores given for: quality of induction, degree of muscle relaxation and ease of intubation. The time to achieve a light plane of anaesthesia, number of supplemental boluses needed and recovery characteristics were also recorded. Chimpanzees were continuously monitored and heart rate (HR), pulse rate (PR), respiratory rate (fR) oxygen saturation of heamoglobin (SpO2), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), rectal temperature, mucous membrane colour and capillary refill time recorded. During the first procedure (TZ) animals underwent a 12 channel ECG, hematology, biochemistry and cardiac biomarker assessment to rule out the presence of pre-existing cardiovascular disease. A detailed echocardiographic examination was carried out by the same blinded observer during both procedures. Data were compared using Student’s paired t-test or Wilcoxon rank tests as appropriate.\ud \ud Results: There was a significant difference for the area under the curves between anaesthetic protocols for HR, SAP, MAP and fR. No significant differences in the echocardiographic measurements were evident. Quality of anaesthesia was significantly better with TZM and no additional boluses were required. The TZ protocol required multiple supplemental boluses.\ud \ud Conclusions and clinical relevance: Both combinations are suitable for immobilization and cardiovascular evaluation of healthy chimpanzees. Further work is required to evaluate the effect of medetomidine in cardiovascular disease.
Published: 2018

6. CFD modeling and evaluation of a bi-stable micro-diverter valve

Author: Riaño Z, J. Sebastian, Guevara L, Marco A, and Belalcazar C, Luis C
Subjects: Turbulence, Microbubbles, Process Engineering, Microburbujas, Turbulencia, Microfluidics, CFD, Diverter valve, Micro fluidos, Válvula de desvío, Ingeniería de Procesos
Abstract: Micro-diverter valves are innovative and efficient devices used to generate microbubbles that can significantly enhance process efficiency in industry. Micro-diverter valves have been experimentally tested and modeled using CFD in previous works. However, a detailed CFD modeling evaluation of these valves has not been performed employing detailed turbulence modeling at transient and steady state. This article presents a three-dimensional CFD simulation and performance evaluation of a bi-stable diverted valve for microbubble generation. In the model, transient and steady state approaches were used to quantify the behavior in the valve. The K - ε standard and k - ε RNG turbulence models were used and compared. Different mesh configurations, mesh generation methods, and both turbulence models were evaluated to find the best set-up to simulate this valve. A brief analysis of the time-step size using the Courant number approach was also performed. Operation conditions at low Reynolds (3800) and high frequency (200 Hz) were used to assess possible industrial applications, thus setting the base for further studies. The results of this work show that at low Reynolds numbers and high frequencies, the valve is able to divert the fluid and thus it may have wider industrial applications. RESUMEN Las válvulas de micro- desviación son dispositivos innovadores y eficientes que se utilizan para generar microburbujas que pueden mejorar significativamente la eficiencia de un proceso en la industria. Las válvulas de microdesviación han sido probadas experimentalmente y modeladas usando CFD en trabajos previos. Sin embargo, hasta el momento no se había llevado a cabo una evaluación del modelado en CFD de éstas válvulas utilizando un modelo detallado de turbulencia en estado transitorio y estable. Este artículo presenta una simulación tridimensional de CFD y la evaluación del rendimiento de una válvula desviada biestable para la generación de microburbujas. En el modelo, fueron utilizados aproximaciones en estado estable y transitorio para cuantificar el desempeño de la válvula. Los modelos k - ε estándar y de turbulencia k - ε RNG fueron utilizados y comparados. Fueron evaluados diferentes métodos de generación y configuraciones de malla y ambos modelos de turbulencia para encontrar la mejor configuración para simular esta válvula. Además se realizó un breve análisis del tamaño del paso de tiempo utilizando el enfoque del número Courant. Fueron evaluadas las condiciones de operación a bajo Reynolds (3800) y alta frecuencia (200 Hz) para posibles aplicaciones industriales, sentando así la base para estudios posteriores. Los resultados de este trabajo muestran que a bajos números de Reynolds y altas frecuencias, la válvula puede desviar el fluido y, por lo consiguiente puede servir en una amplia cantidad de aplicaciones industriales.
Published: 2018

7. Benchmarking Different Treatment Methods for Organic Municipal Solid Waste

Author: Rutz, D., Mergner, R., Janssen, R., Bojan Ribić, Kostic, R., Hadžić, A., Mijić, G., Pukšec, T., Duić, N., Zweiler, R., Doczekal, C., Novakovits, P., Gruevska, A., Antevski, G., Chaloski, M., Mitkovski, D., Petrusevski, K., Cvetkovska, E., Guevara, L. C. L., Rodríguez-Acuña, R., García, A., Médieu, A., and Kazeroni, M.
Subjects: Anaerobic digestion, Beverage industry, Biogas, Biomethane, Catering services, Food industry, Food waste, Municipal solid waste, Source separated waste, Biomass
Abstract: In the EU around 40% of bio-waste (organic fractions of municipal solid waste including food waste) still goes to landfills. In some Member States this waste is almost completely landfilled. An estimation is that about one-third of Europe`s 2020 targets for renewable energy in transport could be met by using biogas produced from bio-waste (including food waste), and around 2% of the EU`s overall renewable energy target could be met if all bio-waste were turned into energy.Modern and environmentally friendly waste management is still not introduced in many European cities and regions. This problem is tackled by the Bin2Grid project which promotes the “food waste to biomethane” concept in four large European cities in order to serve as flagship examples for other cities.The objective of the Bin2Grid project is to support biomethane production and its use in transport by using segregated food waste from the food and beverage industry, catering sector, and from households(MSW) as feedstock. Focus of the Bin2Grid project is on the development of value chain concepts for four European cities: Zagreb (Croatia), Skopje (Macedonia), Malaga (Spain), and Paris (France). The Bin2Grid project highlights the multiple environmental benefits of source-separate waste collection and conversion of that feedstock into biomethane, in comparison to other treatment methods (landfilling, incineration, MBT, composting). A Benchmark Tool was developed by the project and is presented in this paper., Proceedings of the 25th European Biomass Conference and Exhibition, 12-15 June 2017, Stockholm, Sweden, pp. 204-209
Published: 2017
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8. Oxidación catalítica heterogénea de R-(+)-limoneno sobre catalizadores tipo Jacobsen

Author: Cubillos Lobo, Jairo Antonio, Romanelli, Gustavo Pablo, and Paez Guevara, L. A.
Subjects: Ingeniería Química, purl.org/becyt/ford/2.4 [https], Recuperación del catalizador, purl.org/becyt/ford/2 [https], Catalizadores tipo jacobsen, Ingeniería de Procesos Químicos, Diepóxidos, INGENIERÍAS Y TECNOLOGÍAS, R-(+)-limoneno, Limonene, Diepoxides, Jacobsen catalyst
Abstract: The development of heterogeneous catalytic processes is highly desirable in order to overcome somedrawbacks of homogeneous catalysts, such as the separation and recycling of these catalysts. In this work,we report that Jacobsen type catalysts are efficient and selective for the oxidation of R-(+)-limonene to itscorresponding diepoxides using in situ generated dimethyldioxirane (DMD) as oxidant. It was demonstratedthat the solid NaHCO3 addition to the initial reaction mixture, improves the catalytic activity. Additionally,catalyst samples can be recovered and reused at least twice without significant loss of its initial catalyticactivity., El desarrollo de procesos catalíticos heterogéneos es muy deseable dado que se pueden superar las dificultades que presentan los catalizadores homogéneos, tales como la separación y el reciclado de estos catalizadores. En este trabajo, reportamos que los catalizadores tipo Jacobsen son eficientes y selectivos para la oxidación de R-(+)-limoneno a sus correspondientes diepóxidos cuando dimetildioxirano generado in situ es utilizado como agente oxidante. Se demostró que la adición de NaHCO3 sólido, al inicio de la reacción, mejora la actividad catalítica. Además, el catalizador puede ser recuperado y reutilizado al menos dos veces sin pérdida significativa de su actividad catalítica inicial., Centro de Investigación y Desarrollo en Ciencias Aplicadas
Published: 2014

9. Age-Related Standards for Total Lymphocyte, CD4+ and CD8+ T Cell Counts in Children Born in Europe

Author: Giaquinto, Carlo, Rampon, O, Giacomet, V, DE ROSSI, Anita, GROSCH WORNER, I, Mok, J, Bates, I, DE JOSE, I, Hawkins, F, GARCIA RODRIGUEZ MC, DE GUEVARA, L, Pena, Jm, Garcia, Jg, Lopez, Jra, ASENSI BOTET, F, Otero, Mc, PEREZ TAMARIT, D, Orti, A, SAN MIGUEL MJ, Scherpbier, H, Kreyenbroek, M, Boer, K, Bohlin, Ab, Belfrage, E, Naver, L, Levy, J, Hainaut, M, Peltier, A, Goetghebuer, T, Barlow, P, Ferrazin, A, DE MARIA, A, Gotta, C, Mur, A, LOPEZ VILCHEZ MA, Paya, A, Carreras, R, Valerius, Nh, Niemec, T, and Marczynska, M.
Subjects: lymphocytes, Microbiology (medical), Lymphocyte, Human immunodeficiency virus (HIV), Black People, HIV Infections, lymphocytes, CD4(+) cells, CD8(+) cells, human immunodeficiency virus, CD8-Positive T-Lymphocytes, medicine.disease_cause, White People, Acquired immunodeficiency syndrome (AIDS), Pregnancy, Age related, medicine, Humans, Cytotoxic T cell, Lymphocyte Count, Pregnancy Complications, Infectious, Child, Prospective cohort study, Total Lymphocyte Counts, human immunodeficiency virus, business.industry, Age Factors, Infant, Newborn, Infant, CD8(+) cells, medicine.disease, CD4 Lymphocyte Count, Europe, CD4(+) cells, Infectious Diseases, medicine.anatomical_structure, Child, Preschool, Pediatrics, Perinatology and Child Health, Immunology, HIV-1, Female, business, Demography
Abstract: Objective Currently used reference values for immunologic markers in children are largely derived from cross-sectional data from historic, small sample size studies in predominantly white children. There is a lack of reliable age-related standards for immunologic markers, such as CD4+ cell counts, in particular in black children whose values according to recent reports may differ from those in white children. Standards are essential for diagnosing and monitoring childhood diseases such as pediatric human immunodeficiency virus (HIV) infection. Design Prospective cohort study with data on 1781 uninfected children born to HIV-infected mothers in the European Collaborative Study. Methods Age-related standards (centiles) for immunologic markers (CD4+ and CD8+ cell counts and total lymphocyte counts) up to 5 years in black and up to 10 years in white children were constructed using Generalized Additive Models for Location, Scale and Shape method, which allows for variability and skewness of the data. The optimal model was chosen according to the Akaike Information Criterion. Results Patterns and values of total lymphocyte, CD4+ and CD8+ cell counts varied with age, especially in the first 3 years of life, but less so thereafter. Values of all 3 immunologic markers were substantially and significantly lower in black than in white children of the same age. Conclusions We present age-related standards separately for black and white children to aid clinicians in the monitoring of childhood diseases. These standards may also contribute to the decision on an accurate cutoff for CD4+ cell counts for initiating treatment of HIV-infected children.
Published: 2005
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10. Hepatic encephalopathy: A review

Author: Guevara L, Misael Uribe, Paloma Almeda, and Javier Lizardi-Cervera
Subjects: Male, medicine.medical_specialty, Cirrhosis, neurological alteration, Dopamine, Encephalopathy, Specialties of internal medicine, Risk Assessment, Severity of Illness Index, Gastroenterology, Pathogenesis, Liver Function Tests, Internal medicine, Severity of illness, medicine, Humans, Hepatic encephalopathy, Coma, Hepatic failure, Hepatology, medicine.diagnostic_test, Nutritional Support, business.industry, astrocytes, General Medicine, encephalopathy, Prognosis, medicine.disease, Combined Modality Therapy, Survival Analysis, Anti-Bacterial Agents, ammonium, RC581-951, Hepatic Encephalopathy, Drug Therapy, Combination, Female, medicine.symptom, Complication, business, Liver function tests, Blood Chemical Analysis
Abstract: Hepatic encephalopathy (HE) is a complication that presents in as many as 28% of patients with cirrhosis, and reported up to ten years after the diagnosis of cirrhosis. Commonly, it is observed in patients with severe hepatic failure and is characterized by neuropsychiatric manifestations that can range in severity from a mild alteration in mental state to a coma; additionally, some neuromuscular symptoms can be observed. This complication of either acute or chronic hepatic disease is the result of a diminished hepatic reservoir and inability to detoxify some toxins that originate in the bowel. Today, the role of astrocytes, specifically the Alzheimer type II cells, is known to be very important in the pathogenesis of the hepatic encephalopathy, and will be reviewed later. In conclusion, the objectives of this review are: • To understand the pathogenesis of hepatic encephalopathy To recognize the precipitating factors, as well as preventive measures for the development of the hepatic encephalopathy To describe the new classification of hepatic encephalopathy and its clinical implications To recognize the clinical manifestations and stages of the disease To understand the main diagnostic tests used to detect the hepatic encephalopathy To describe the main therapeutic treatments of hepatic encephalopathy.
Published: 2003
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11. [Untitled]

Author: Vega H, Nahum Méndez-Sánchez, Guevara L, Martha H. Ramos, Vargas-Vorackova F, and Misael Uribe
Subjects: Gerontology, medicine.medical_specialty, Physiology, business.industry, Gastroenterology, Odds ratio, Ethnic origin, Disease, medicine.disease, Obesity, Epidemiology, Medicine, Risk factor, business, Parity (mathematics), Body mass index, Demography
Abstract: According to epidemiological studies, gallstonedisease is a very common disease in Mexican-Americansand Mexicans. However, the major risk factors forcholelithiasis in Mexicans have not been identified. We designed a case-control study in a group ofMexican subjects with and without gallstone diseaseconfirmed by ultrasound. These subjects wereprospectively studied over a three-year period. Clinical and epidemiological data were collected bymeans of a questionnaire. A total of 1500 subjects wereincluded in this study: 1000 with and 500 withoutgallstone disease. The major risk factor in both men and women was body mass index [odds ratio (OR)1.64 and 1.96, respectively; P < 0.008 and 0.001]. Inaddition, parity was an important factor in women (OR2.17, P < 0.001), whereas age was associated withgallstone disease in men (OR 1.43, P < 0.001). Wefound that body mass index, parity, and age were theprincipal risk factors for gallstone disease in thisgroup of Mexican subjects. These results are similar tothose found in Mexican-Americanpopulations.
Published: 1998
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12. Beneficial Effect of Carbohydrate Maldigestion Induced by a Disaccharidase Inhibitor (AO-128) in the Treatment of Chronic Portal-Systemic Encephalopathy: A Double-Blind, Randomized, Controlled Trial

Author: J.L. Poo, G García-Ramos, Misael Uribe, Guevara L, Segundo Moran, and Nahum Méndez-Sánchez
Subjects: Male, medicine.medical_specialty, Malabsorption, Lactitol, Encephalopathy, Disaccharidases, Disaccharides, Gastroenterology, Intestinal absorption, Lactulose, chemistry.chemical_compound, Double-Blind Method, Internal medicine, medicine, Humans, Enzyme Inhibitors, Hepatic encephalopathy, business.industry, Middle Aged, Carbohydrate, Cyclohexanols, medicine.disease, Disaccharidase, Endocrinology, Intestinal Absorption, chemistry, Hepatic Encephalopathy, Female, business, medicine.drug
Abstract: The most widely used treatment of portal-systemic encephalopathy (PSE) is the administration of oral, non-absorbable disaccharides. Theoretically, the inhibition of intestinal disaccharidases should induce malabsorption of disaccharides and increase delivery of undigested carbohydrates to the colon, thus stimulating the effects of lactulose and other non-absorbable disaccharides (that is, lactitol and lactose). AO-128 is an N-substituted derivative of valeolamine, an aminocyclitol that selectively inhibits intestinal disaccharidases. This study was performed to investigate whether AO-128 could be used as adjuvant therapy for the treatment of mild PSE in cirrhotic patients.A double-blind, randomized, controlled trial was performed in 35 cirrhotic patients with PSE. Patients were given a 2-week treatment consisting of AO-128 (2 mg three times daily) or an identical placebo. The following features of PSE syndrome were assessed in a semiquantitative fashion before and after I and 2 weeks of therapy: mental state, asterixis, number connection test (NCT), venous blood ammonia concentration, electroencephalogram (EEG), and overall PSE index (PSEI). More patients receiving AO-128 than patients receiving placebo showed40% improvement in the PSEI (83% versus 35%; P0.05). The mean stool pH decreased from 5.8+/-0.3 to 5.5+/-0.3 (P0.004) after AO-128 treatment, whereas no changes were observed in the placebo group. The EEG and nitrogen balance did not show significant changes in any of the two groups. A significant improvement was seen in the NCT performance after AO-128 (from grade 2.0+/-1.04 to grade 1.25+/-0.87; P0.05). Seven patients treated with AO-128 developed diarrhea, as compared with none in the placebo group (P0.05).These results suggest that AO-128 may be useful in the treatment of PSE, although further studies are required to establish the benefit of AO-128 and determine adequate individual doses.
Published: 1998
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13. Identificación De Los Factores De Riesgos Y Riesgos Asociados Al Trabajo En Altura Pereira (Risaralda) 2012

Author: Guevara L., Carolina, Castro, Diana Milena, Rojas V., Diana Marcela, and Universidad del Quindio-Fernando Henao Robledo - Luz Emilia Villegas Londoño
Subjects: Factores, Riesgos
Abstract: El trabajo no es un juego y siempre conlleva a un riesgo, pero la mayoría de los accidentes tienen causas conocidas, pero disponemos de los medios para evitarlos. Un entorno de trabajo seguro, medios técnicos y capacitaciones adecuadas son imprescindibles para disminuir las lesiones laborales. El trabajo que se realiza en altura por su propia naturaleza implica situaciones de riesgo, elegimos investigar sobre el tema para establecer un material de consulta rápida en términos relacionados con la prevención de riesgos laborales y pautas para la protección de los empleados que participan en actividades con una altura superior a 1.50mts al aire libre o en interiores de trabajo que los expongan a posibles caídas de altura El Ministerio de salud y protección social, tiene como objetivo la prevención de riesgos laborales, para evitar accidentes de trabajo ha expedido la resolución 1409 del 2012 en las que responsabiliza a los diferentes actores de las obligaciones que le competen tanto al empleador como a los trabajadores. El trabajo en alturas es una actividad de alto riesgo y representa una de las primeras causas de accidentalidad y muerte en el trabajo por lo que se requiere de planeación, organización, ejecución, control y evaluación de las actividades desempeñadas por los trabajadores., Justificación, Definición del Problema, Objetivos, Pregrado, Profesional en Seguridad y Salud en el Trabajo
Published: 2012

14. Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

Author: Parving, Hh, Brenner, Bm, Mcmurray, Jj, de Zeeuw, D, Haffner, Sm, Solomon, Sd, Chaturvedi, N, Persson, F, Desai, As, Nicolaides, M, Richard, A, Xiang, Z, Brunel, P, Pfeffer, Ma, Viberti, G, Lachin, Jm, Zinman, B, Pedersen, Tr, Villamil, As, Juncos, L, Prager, R, Verpooten, G, Zanella, Mt, Leiter, L, Pan, C, Wang, H, Botero, R, Cifkova, R, Christiansen, Js, Groop, Ph, Marre, M, Haller, H, Nickenig, G, Siamopoulos, K, Gero, L, Maggioni, A, Remuzzi, G, Katayama, Ss, Kim, Sg, Petrulioniene, Z, Lok, D, Kooy, A, Jorde, R, Medina, F, Polonia, J, Wong, Ks, Dukat, A, Rayner, Bl, Ruilope, L, Weiss, L, Wuethrich, R, Sheu, W, Sritara, P, Comlekci, A, Bilous, R, Toto, R, Jamerson, K, Carillo, E, Orias, M, Kuschnir, E, Rusculleda, M, Garcia, S, Farias, E, Lema, L, Hominal, M, Montaña, O, Sala, J, Diaz, M, Piskorz, D, Vita, N, Litwak, L, Sinay, I, Marin, M, Massari, P, Majul, C, Aizemberg, D, Azize, Gm, Bartolacci, I, Reboredo, A, Vico, M, Milesi, R, Sessa, H, Wassermann, A, Margulis, F, Zangroniz, P, Watschinger, B, Toplak, H, Paulweber, B, Drexel, H, Francesconi, C, Foeger, B, Mayer, G, Braun, Rk, Brath, H, Gaal, Lv, Niepen, Pv, Persu, A, Vercammen, C, Vriese, Ad, Coucke, F, Mathieu, C, Fery, F, Treille, S, Meeus, G, Acker, Kv, Scheen, A, Tits, J, Ruige, J, Krzesinski, Jm, Hollanders, G, Liénart, F, Dendale, P, Quinonez, M, Arnouts, P, Vanuytsel, J, Zanella, M, Mion D., Jr, Forti, A, Almeida, F, Cunha, R, de Paula RB, Brandao, A, Rocha, J, Krieger, E, Feitosa, G, Saraiva, J, Martin, J, Hissa, Mn, Schmid, H, Felicio, J, Sgarbi, J, Oigman, W, Bowering, K, Garceau, C, Berlingieri, Jc, Weisnagel, Sj, Hardin, P, Powell, C, Turcot, R, Muirhead, N, Aronson, R, Barima, Yt, Steele, Aw, Pandey, S, Woo, V, Cha, J, Dattani, D, Godin, C, Gupta, M, Saunders, K, Tellier, G, Ting, R, Tobe, S, Chouinard, G, Schlosser, R, Khandwala, H, Ekoe, Jm, Harris, Sb, Pichette, V, Lachance, P, Ooi, Tc, Tildesley, H, Barrett, B, Cournoyer, S, Lu, J, Zhang, H, Liu, X, Yan, S, Qi, X, Li, Q, Li, H, Lv, X, Yang, J, Sun, N, Xia, W, Wang, N, Tong, N, Mei, C, Gu, S, Zhang, J, Chen, X, Li, L, Su, B, Wang, L, Qiu, M, Wu, X, Liu, Z, Jia, W, Xu, G, Dong, J, Zhu, D, Zhang, M, Yan, J, Liu, B, Chen, J, Fu, J, Yan, L, Zhan, X, Zhong, L, Yang, T, Ma, J, Xu, M, Xu, X, Shi, B, Ji, Q, Zhong, H, He, R, Yuan, Z, Zhou, Z, Lin, H, Yang, W, Ke, Y, Hong, T, Franco, C, Casas, L, Triana, A, Jaramillo, C, Hernandez, E, Barrera, C, Blanco, D, Stipal, R, Widimsky, P, Dohnalova, L, Komroskova, M, Kvapil, M, Belobradkova, J, Tesar, V, Vodnansky, P, Kocourkova, B, Lervang, Hh, Perrild, H, Rossing, P, Oestergaard, O, Juhl, H, Thorsteinsson, B, Snorgaard, O, Urhammer, S, Egstrup, K, Tikkanen, T, Helin, K, Rinne, J, Lahtela, J, Strand, J, Valtonen, E, Saari, M, Kananen, K, Savela, K, Blacher, J, Aldigier, Jc, Zaoui, P, Fauvel, Jp, Gouet, D, Valensi, Pe, Charpentier, G, Marechaud, R, Penfornis, A, Ovize, M, Kovalchuck, Aa, Dellanna, F, Schoen, N, Groeschel, W, Eickhoff, F, Hanefeld, M, Merke, J, Rambausek, M, Zimmermann, U, Stuetz, W, Vosskuehler, A, Hevendehl, G, Schax, U, Lehmann, G, Haack, A, Hilgenberg, J, Klausmann, G, Adelberger, V, Gessner, S, Fiesselmann, A, Oerter, E, Hohenstatt, T, Groeschel, A, Behnke, T, Sisting, Rt, Schoch, D, Bieler, T, Schleyer, S, Altes, U, Klepzig, C, Rudofsky, G, Mueller, G, Burkhardt, F, Reschke, K, Senftleber, I, Wiesweg, Ck, Herrmann, Hj, Brandstetter, R, Segner, A, Schmitt, H, Rippert, R, Goebel, R, Schreibmueller, F, Pencz, I, Ott, P, Migdalis, I, Pappas, S, Pagkalos, E, Yalouris, A, Tsapas, A, Maltezos, E, Tentolouris, N, Papadakis, I, Ioannidis, G, Goumenos, D, Corona, V, Gonzalez, R, Haase, F, Monterroso, V, Sánchez, V, Turcios, E, Wyss, F, Arango, Jl, Bako, B, Deak, L, Dömötör, E, Dudas, M, Fulop, T, Kiss, I, Koranyi, L, Lengyel, Z, Nyirati, G, Oroszlan, T, Aniko, S, Vörös, P, Kapocsi, J, Wittmann, I, Paragh, G, Abraham, G, Tandon, N, Thomas, N, Mohan, V, Sahay, R, Sethi, B, Rao, V, Kumar, S, Chowdhury, S, Dharmalingam, M, Seshiah, V, Bantwal, G, Viswanathan, V, Yajnik, C, Adhikari, P, Krishnan, U, Varthakavi, P, Hiremath, J, Bhattacharyya, A, Dani, S, Modi, Kk, Glorioso, N, Morosetti, M, Veglio, Franco, Perticone, F, Dotta, F, Quarello, F, Sesti, G, Aiello, A, D'Ospina, A, Giordano, C, Novo, S, Santoro, A, Ferri, C, Capuano, V, Trimarco, B, Tonolo, G, Villa, G, De Pellegrin, A, Zanette, G, Federici, M, Aucello, G, Piatti, P, Vinciguerra, A, Mannarino, E, Taddei, S, Filetti, S, Grandaliano, G, Marchionni, N, Lambiase, C, Locatelli, F, Scanferla, F, Lembo, G, Leotta, S, Mos, L, Calatola, P, Fogari, R, David, S, Pedrinelli, R, Pignone, Am, Cozzolino, D, Bevilacqua, Mt, Catena, C, Del Prato, S, Cerasola, G, Frontoni, S, Falcone, C, Porta, A, Bonora, E, Cocchi, R, Fucili, A, Frisinghelli, A, Volpe, M, Carugo, S, Gambardella, S, Spagnuolo, V, Maglia, G, D'Angelo, Ar, Corsi, A, Limone, Pp, Guarnieri, A, Ghigo, Ezio, Ronchi, E, Ravera, M, Scioli, Ga, Sekiguchi, M, Aoki, S, Ogawa, Y, Seino, H, Onishi, Y, Tojo, A, Narimiya, M, Iwaita, Y, Takeda, H, Shimizu, H, Yamada, T, Kojima, S, Zushi, S, Kaneko, S, Matsumoto, A, Kajiyama, S, Fujita, H, Shikata, K, Tone, A, Matsubayashi, S, Tanaka, S, Sekigami, T, Tatsukawa, Y, Abe, N, Kawahara, K, Kasahara, H, Maeda, Y, Suzuki, Y, Okamoto, H, Tachi, K, Yamada, K, Uzu, T, Itou, T, Fukui, T, Kim, S, Kim, Y, Cho, W, Kwak, I, Chae, D, Oh, H, Ha, S, Shin, Y, Cha, D, Kang, S, Lim, C, Song, J, Kwon, Y, Badariene, J, Labutiniene, Ip, Zabuliene, L, Poteliuniene, V, Miglinas, M, van den Meiracker AH, Gregoor, Pj, Luik, Aj, van Loon BJ, Feenstra, Hj, Kaasjager, Ha, Viergever, Pp, Woittiez, Aj, van Bemmel, T, Lieverse, Ag, Simsek, S, Gaillard, Ca, van der Zwaan, C, Lok, Dj, Spiering, W, Nierop, Pr, Baggen, Mg, Leendert, Rj, de Jong, A, Leurs, Pb, Vincent, Hh, Wins, Eh, Voors, Aa, Ronner, E, Heeg, Je, van Hal JM, Boermans, T, Feis, Wl, Mostard, G, Bakker, Rc, Dunselman, Ph, Skeie, S, Istad, H, Skjelvan, G, Gronert, J, Tomala, T, Gudnason, S, Torvik, Dt, Risberg, K, Abedini, S, Cabrera, W, Medina, B, Herrada, B, Saavedra, A, Polonia, Dj, Providencia, Dl, Carvalho, D, Vasconcelos, Mp, da Silva GF, Branco, P, Gil, Dv, da Costa AG, da Silva PM, Arez, L, Martins, L, Birne, R, Dzuponova, J, Surovcikova, M, Culak, J, Filipova, S, Andre, I, Stevlik, J, Uhliar, R, Fabryova, L, Benacka, J, Koleny, D, Szentivanyi, M, Spisak, V, Pella, D, Pastrnakova, E, Martinka, E, Chua, T, Lau, T, Ng, Tg, Yeoh, Ly, Bhana, Sa, Rayner, B, Wellmann, H, Amod, A, Ranjith, N, Ahmed, F, Rheeder, P, Makan, H, Naicker, P, Podgorski, G, De Teresa, E, Olivan, J, Fernandez, Vl, Povedano, St, Terns, M, Ricart, W, Gonzalez, Jm, Fernandez, P, Parreño Lde, T, Redon, J, Parra, J, Calvo, C, Lopez, I, Puig, Jg, Calle, A, Garcia, Jc, Lopez, Jm, Jimenez, Ml, Fraile, B, Perez, Js, Nadal, Jj, Guija, E, Calviño, J, Barrios, V, Iglesias, Jn, Armario, P, Garcia, M, Aranda, P, Brotons, C, Gomez, P, Catelao, Am, Cusachs, Ar, Sarro, M, Martinez, V, dell Valle MH, Trias, F, Comas, A, Salvador, N, Martinez, F, Hernandez, F, Martinez, J, Mateos, C, Peral, Jl, Tolosana, J, Sobrino, J, Isart, J, Vizcaino, J, Vega, Ff, Zamorano, Jl, Bacariza, M, Soubriet, A, Fernández Cruz, A, Querejeta, R, Leira, Vm, Iglesias, Fe, Ibrik, O, Martin, D, Nanclares, Ms, Mediavilla, Jd, Galceran, Jm, Lopez, A, Muros, T, Pascual, J, Casalla, F, Tornero, F, Fernandez, G, Pettersson, P, Olsen, H, Franke, F, Stroembom, U, Furuland, H, Larnefelt, H, Allemann, Y, Krapf, R, Gerber, P, Munger, R, Hayoz, D, Graf, Hj, Burnier, M, Petrillo, A, Batt, R, Constam, En, Moccetti, T, Bianda, T, Rickli, H, Bulliard, C, Wu, Kd, Lin, Sh, Wu, Cj, Sheu, Wh, Su, Sl, Chen, Sc, Chou, Cw, Lee, Ct, Yang, Tc, Chen, Hc, Sukonthasarn, A, Sriratanasathavorn, C, Eiam Ong, S, Supasyndh, O, Chanchairujira, T, Kitiyakara, C, Arici, M, Usalan, C, Guneri, S, Koc, M, Kalender, B, Ates, K, Gurgun, C, Araz, M, Demirbas, B, Biernacki, W, Calvert, J, Eavis, P, Kerrane, J, Litchfield, J, Middleton, A, Roberts, J, Simpson, H, Charles, H, Jardine, A, Fisher, M, Banerjee, D, Gallen, I, Gnudi, L, Harvey, J, O'Hare, P, Vora, J, Winocour, P, Soran, H, Browne, D, Darko, D, Mancebo, Jg, de Roa ER, Antepara, N, Carrillo, E, Berrizbeitia, M, Guevara, L, Pernalete, N, Ontiveros, C, Zigrang, W, Blakney, E, Rosenblit, P, Weinstein, R, Klaff, L, Lipetz, R, Busick, E, Tung, P, Cooperman, M, Michael, S, Sun, Ch, Hart, T, Maddux, A, Bowden, R, East, C, Arakaki, R, Villafuerte, B, Mamish, Z, Mendez, R, Connery, L, Nour, K, Wynne, A, Busch, R, Zamora, B, Sachson, R, Prasad, J, Lasala, G, Smith, M, Fitz Patrick, D, Ruiz Rivera, L, Barranco, E, Solomon, R, Woolley, A, Brown, C, Freedman, Z, Schmidt, S, Pollock, J, Ruddy, M, Kopyt, Np, Bazzi, A, Horowitz, B, Feng, W, Wahl, T, Duprez, D, Gilbert, J, Steigerwalt, S, Jacqmein, J, Gorton, S, 3rd, Allison J., Pino, J, Lock, J, Leimbach, W, Anderson, J, Beacom, M, Craig, W, Gorson, D, Kerstein, H, Segal, S, Downey, H, Ledger, G, Mcgill, J, Gabriel, J, Nolen, T, Levinson, L, Williams, T, Levenson, D, Lerman, S, Minehart, C, Agarwal, N, Verma, S, Valitutto, M, Demetry, K, Mersey, J, Koeper, D, Fanti, P, Eng, G, Grimm, R, Fagan, T, Bajaj, M, Katz, L, Portnay, G, Altschuller, A, Desai, V, Bilazarian, S, Ipp, E, Rodelas, R, Burstein, D, Berg, J, Velez, J, Lund, R, Rekhi, A, Martin, E, Robertson, D, Singh, N, Narayan, P, Moustafa, M, Lanier, D, Seidner, M, Phillips, A, Vaughters, B, Sprague, A, Swartz, S, Lopez, R, Kumar, J, Bressler, P, Sadler, L, Wise, J, Kilbane, A., and Groningen Kidney Center (GKC)
Subjects: Male, Hyperkalemia, CARDIOVASCULAR MORTALITY, BLOOD-PRESSURE, Angiotensin-Converting Enzyme Inhibitors, Type 2 diabetes, GLOMERULAR-FILTRATION-RATE, DOUBLE-BLIND, chemistry.chemical_compound, Fumarates, cardiovascular disease, Renin, Treatment Failure, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, 610 Medicine & health, diabetes, Medicine (all), Hazard ratio, aliskiren, diabete, trial clinico, Liter, General Medicine, Middle Aged, hypertension, Cardiovascular Diseases, Combination, HEART-FAILURE, Drug Therapy, Combination, Female, Kidney Diseases, type 2 diabetes, medicine.symptom, Type 2, medicine.medical_specialty, Patient Dropouts, Urology, Hypokalemia, Aliskiren, chronic kidney disease, Placebo, Angiotensin Receptor Antagonists, LEFT-VENTRICULAR DYSFUNCTION, Drug Therapy, Double-Blind Method, Diabetes Mellitus, medicine, Humans, CONVERTING-ENZYME INHIBITORS, Antihypertensive Agents, Aged, Amides, Diabetes Mellitus, Type 2, Follow-Up Studies, business.industry, medicine.disease, Confidence interval, Surgery, Blood pressure, MYOCARDIAL-INFARCTION, chemistry, SYSTOLIC DYSFUNCTION, FOLLOW-UP, business
Abstract: BACKGROUND This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both. METHODS In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level. RESULTS The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P = 0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, = 6 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P CONCLUSIONS The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful. (Funded by Novartis; ALTITUDE ClinicalTrials.gov number, NCT00549757.)
Published: 2012
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15. First interim analysis of the GIDEON (Global Investigation of therapeutic decisions in hepatocellular carcinoma and of its treatment with sorafeNib) non-interventional study

Author: Lencioni, RICCARDO ANTONIO, Kudo, M, Ye, Sl, Bronowicki, Jp, Chen, Xp, Dagher, L, Furuse, J, Geschwind, Jf, Ladrón de Guevara, L, Papandreou, C, Sanyal, Aj, Takayama, T, Yoon, Sk, Nakajima, K, Cihon, F, Heldner, S, and Marrero, Ja
Published: 2012

16. NARVAL : un système d'acquisition distribué

Author: Grave, X., Guevara, L., Institut de Physique Nucléaire d'Orsay (IPNO), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [INFO.INFO-OH]Computer Science [cs]/Other [cs.OH], [INFO.INFO-OS]Computer Science [cs]/Operating Systems [cs.OS]
Abstract: NARVAL est un système d'acquisition distribué écrit en Ada pouvant repartir la charge d'acquisition de un à plusieurs dizaines de coeurs. L'ensemble des processus répartis sur le réseau se comporte comme un seul processus échangeant des données à haut débit. Une interface vers du code utilisateur est disponible en C et C++. Le fonctionnement interne de NARVAL ainsi que plusieurs exemples concrets seront présentés : - Acquisition "typique" de Physique Nucléaire (VME) - Instrument mono machine (numériseur GAGE) - Gestion du flot de données du détecteur AGATA NARVAL est utilisé dans plusieurs laboratoires (entre autres) : - CEA Bruyère le Chatel - CSNSM Orsay - GANIL Caen - IPN Orsay - LNL Legnaro - LPC Caen - LPNHE Paris L'acronyme de NARVAL correspond à : Nouvelle Acquisition temps Réel Version 1.8 Avec Linux
Published: 2010

17. Role of the distal splenorenal shunt in management of variceal bleeding in Latin America

Author: Takeshi Takahashi, Jorge Ortiz, Guadalupe Garcia-Tsao, Miguel Angel Mercado, Héctor Orozco, Manuel Tielve, Guevara L, and Armando Hernández-Cendejas
Subjects: Adult, Male, medicine.medical_specialty, Variceal bleeding, Cirrhosis, Adolescent, Encephalopathy, Esophageal and Gastric Varices, Postoperative Complications, Humans, Medicine, Child, Aged, Retrospective Studies, Distal splenorenal shunt, business.industry, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Thrombosis, Surgery, Portal hypertension, Female, Emergencies, Gastrointestinal Hemorrhage, business, Splenorenal Shunt, Surgical, Shunt (electrical)
Abstract: In the early 1970s, we began to perform selective shunts on a regular basis for the treatment of portal hypertension. In a 15-year period, 177 patients (155 with liver cirrhosis) were treated with 3 kinds of selective shunts: the Warrent shunt (128 patients) the end-to-end splenorenal shunt (29 patients), and the splenocaval shunt (20 patients). One hundred sixty-seven of the procedures were elective. Operative mortality was 14%, and survival for the Child's class A group was 75% at 1 year, 69% at 5 years, and 65% at 15 years. Incapacitating encephalopathy was observed in 7% of the patients, rebleeding in 6%, and shunt thrombosis in 6%. Postoperative portal vein alterations included reduced venous diameter (13%) and thrombosis (21%). Experience with the Warren shunt in schistosomiasis, a disease in which normal liver function is the rule in Latin American countries, is discussed. We believe that, when feasible, the selective shunts are the treatment of choice for portal hypertension in Latin American countries.
Published: 1990
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18. Necrólisis epidérmica tóxica asociada al uso de ácido valproico

Author: Agelvis Mc, González-De Guevara L, Berardi-Lorenzón Ml, Guevara-Campos J, Ibrahim G, and Mejías P
Subjects: Traditional medicine, Chemistry, Neurology (clinical), General Medicine, ácido valproico
Published: 2010
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19. Aciduria metilmalónica asociada a convulsiones mioclónicas, retraso psicomotor e hipsarritmia

Author: Medina-Atopo M, González-de-Guevara L, and José Guevara-Campos
Subjects: Neurology (clinical), General Medicine
Abstract: Introduccion. Desde hace muchos anos se sabe que las acidurias organicas son causantes de problemas neurologicos, como convulsiones, estupor, coma y retraso psicomotor y mental. Dentro de las acidurias organicas se encuentran la aciduria propionica, la aciduria metilmalonica (AMM), la acidemia isovalerica, la acidemia lactica y la acidemia glutarica tipo I. Sin embargo, la asociacion de la AMM con una actividad electrica cerebral caracterizada por un patron hipsarritmico, convulsiones de dificil control terapeutico y retraso psicomotor, es muy rara. Casos clinicos. La observacion de dos pacientes, uno masculino y otro femenino, con retraso psicomotor, crisis convulsivas mioclonicas erraticas, patron encefalografico hipsarritmico, y la demostracion por medio de la cromatografia de gases y espectrometria de masas de un aumento de la excrecion urinaria de acido metilmalonico, sustentan el diagnostico de AMM en ambos casos. En un paciente, la RM cerebral con gadolinio mostraba lesiones compatibles con atrofia cerebral. La restriccion proteica y la administracion de vitamina B12 y lcarnitina devolvieron la normalidad neurologica y redujeron la excrecion urinaria de acido metilmalonico en uno de ellos. Conclusiones. Hasta donde sabemos, estos son los primeros casos de AMM que se acompanan de hipsarritmia. La rareza de esta presentacion clinica con las caracteristicas descritas nos hace sospechar que estamos ante un nuevo sindrome clinico
Published: 2003
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20. Lactitol, a second-generation disaccharide for treatment of chronic portal-systemic encephalopathy

Author: Heloisa Toledo, Gian-Paolo Ravelli, Franz Perez, Guevara L, Guillermo García-Ramos, Misael Uribe, Florencia Vargas, and Sofia Gil
Subjects: Male, medicine.medical_specialty, Randomization, Cirrhosis, Lactitol, Physiology, Encephalopathy, Lactose, Gastroenterology, law.invention, Random Allocation, chemistry.chemical_compound, Sugar Alcohols, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Humans, Clinical Trials as Topic, business.industry, Hepatobiliary disease, Middle Aged, medicine.disease, Crossover study, Surgery, chemistry, Hepatic Encephalopathy, Female, business
Abstract: A double-blind crossover trial was performed to test the therapeutic usefulness and safety of lactitol, a beta-galactoside sorbitol, against lactose in 18 patients with chronic portal-systemic encephalopathy (PSE). The study included four periods: two for washout and two for lactitol and lactose administration. During washout periods, which lasted two weeks each, patients were stabilized with neomycin plus milk of magnesia. Lactitol and lactose were administered during four weeks each. Ten patients were randomly assigned to receive lactose (group A) and eight patients to receive lactitol (group B) first. PSE parameters, ie, mental state, number connection test performance, asterixis and blood ammonia levels were assessed fortnightly. Electroencephalographic tracings and stool pHs were evaluated at the end of each study period. After the first administration of lactose and lactitol, no statistically significant differences in PSE parameters were found. At the same stage, a significant stool acidification (P less than 0.05) was detected. It is concluded that lactitol seems to be safe and efficacious in treating patients with chronic PSE.
Published: 1987
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21. Survival and quality of life after selective portasystemic shunts

Author: Misael Uribe, Guevara L, Javier Elizondo, Campuzano M, Héctor Orozco, Juan-Ramón Aguilar, and Jorge Hernández-Ortiz
Subjects: Adult, Liver Cirrhosis, Male, Variceal bleeding, medicine.medical_specialty, Adolescent, Encephalopathy, Hospital mortality, medicine, Humans, Portasystemic Shunt, Surgical, Survival rate, Aged, Distal splenorenal shunt, business.industry, Surgical mortality, General Medicine, Middle Aged, Prognosis, medicine.disease, Surgery, Quality of Life, Female, business, Shunt (electrical)
Abstract: Selective portasystemic shunts were performed in 55 consecutive patients; 27 underwent end-to-end selective renosplenic shunt, 18 distal splenorenal shunt and 10 splenocaval shunt. Thirty-one patients were in Child's class A, 18 were in class B and 6 in class C. Hospital mortality for the whole group was 16 percent and occurred less frequently in class A than in class B and C patients. Five year predicted survival for the whole group was 59 percent. At the same period of follow-up, class A patients had a higher survival rate than those in class B and C (83 percent versus 36 percent; p < 0.01). No striking difference in 5 year survival was evident in alcoholics and nonalcoholics (52 percent versus 61 percent). After surgery, long-term portasystemic encephalopathy and bleeding were noted in 2 of 36 survivors. For class A patients, selective portal shunts offer an adequate and relative safe method for decreasing mortality due to variceal bleeding.
Published: 1981
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22. Treatment of chronic portal systemic encephalopathy with bromocriptine

Author: M. A. Marquez, Guevara L, Misael Uribe, G Garcĭa-Ramos, and A Farca
Subjects: Constipation, Hepatology, business.industry, Standard treatment, Gastroenterology, Cathartic, Placebo, Bromocriptine, law.invention, Clinical trial, Randomized controlled trial, law, Anesthesia, Medicine, medicine.symptom, business, medicine.drug, Asterixis
Abstract: A randomized double-blind clinical comparison of bromocriptine, a new dopamine agonist, and placebo was performed on 7 cirrhotic patients with chronic portal systemic encephalopathy (PSE). Before given either medication, patients were stabilized with a standard treatment (neomycin and cathartics). Serial semiquantitative assessments were done, including mental state, asterixis, number connection test, electroencephalogram, and ammonia blood levels. Three patients developed signs of precoma while ingesting both placebo and bromocriptine. Two patients experienced precoma only with placebo, and another patient only while taking bromocriptine. One patient remained awake throughout the study. All patients responded initially to neomycin and cathartics. Bromocriptine proved not to be significantly superior to placebo and was always inferior to standard treatment. During treatment with bromocriptine, 3 patients experienced constipation. This may be partially responsible for the ineffectiveness in the treatment of PSE.
Published: 1979
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23. Flora microbiana en elaborados de aceitunas verdes en la región de Murcia. Evolución cualitativa durante la fermentación

Author: Guzmán Giménez, Ginés, Guevara, L. A., Laencina Sánchez, José, and Departamentos y Servicios::Departamentos de la UMU::Biología Vegetal
Subjects: Alimentos, 5 - Ciencias puras y naturales::50 - Generalidades sobre las ciencias puras [CDU], Conservación
Abstract: A lo largo del proceso normal de fermentación en salmuera se estudia en la región de Murcia la flora microbiana de cinco tipos de aceitunas (subvariedades Manzanilla Fina y Carrasqueña, Verdial, Hojiblanca y las variedades Cacereña) sometidas al tratamiento previo de «cocido». La flora heterogénea —que incluye bacterias Gram-negativas, bacterias lácticas y levaduras— con predominio de las poblaciones de bacilos Gram-negativos en los primeros días del proceso fermentativo, evoluciona hasta que éstos desaparecen —entre la primera y segunda semana, según la clase de aceitunas— y aumenta el contenido de bacterias lácticas y levadiiras hasta alcanzar el tercer y cuarto mes, donde se aprecia la importancia de las levaduras frente a lactobacilos.
Published: 1983

24. Deficiency of protein C in patients with portal vein thrombosis

Author: Guevara L, Rafael Hurtado, Jorge Hernández-Ortiz, Marco A. Casillas, Roger Anaya, Guadalupe Garcia-Tsao, Hector Orozco, Guillermo J. Ruiz-Argüelles, Edmundo Guraieb, and Takeshi Takahashi
Subjects: Adult, Male, medicine.medical_specialty, Sugiura procedure, Mesenteric Veins, Protein C deficiency, Recurrence, Hypertension, Portal, Mesenteric Vascular Occlusion, medicine, Humans, Hepatology, medicine.diagnostic_test, business.industry, Portal Vein, Protein C Deficiency, Thrombosis, Middle Aged, medicine.disease, Surgery, Portal vein thrombosis, Liver biopsy, Portal hypertension, Upper gastrointestinal bleeding, Varices, business, Gastrointestinal Hemorrhage, Protein C
Abstract: Portal vein thrombosis has been considered idiopathic in 50% of cases reported in adults. Protein C deficiency is a recently described disorder characterized by a predisposition to develop thromboembolic disease. We report the findings in two patients with portal hypertension and bleeding varices due to portal vein thrombosis in whom a deficiency of protein C was present. Both cases were very similar, with a history of recurrent episodes of systemic thromboembolic disease, mesenteric venous thrombosis that required intestinal resection and upper gastrointestinal bleeding from gastroesophageal varices. Portal hypertension as well as portal vein thrombosis were demonstrated. The hematologic work-up revealed a deficiency of protein C. Both patients were subjected to the Sugiura procedure, and anticoagulation was instituted thereafter. At the time of surgery, a liver biopsy was performed, which was reported as “normal.” Two years and 3 months, respectively, after surgery both patients are in good condition. We conclude that protein C deficiency should be investigated in all cases of portal vein thrombosis, especially in those with a history of thromboembolic disease elsewhere.
Published: 1988

25. Type determination for SN 2005L

Author: Aldering, G., Lee, B. C., Loken, S., Peter Nugent, Perlmutter, S., Siegrist, J., Scalzo, R., Thomas, R. C., Wang, L., Adam, G., Bacon, R., Bonnaud, C., Capoani, L., Dubet, D., Henault, F., Lantz, B., Lemonnier, J. -P, Pecontal, A., Pecontal, E., Blanc, N., Boudoul, G., Bongard, S., Castera, A., Copin, Y., Gangler, E., Sauge, L., Smadja, G., Kessler, R., Antilogus, P., Astier, P., Barrelet, E., Garavini, G., Gilles, S., Guevara, L. -A, Imbault, D., Juramy, C., Pain, R., Taillet, R., Vincent, D., Baltay, C., Rabinowitz, D., and Bauer, A.

26. Effect of a thione on sleep disturbances associated with chronic pain

Author: Ayala-Guerrero, F., Guevara, L. U., Taboada, J., and Roberto Martinez

27. Type Determination for SN 2005ac

Author: Aldering, G., Lee, B. C., Loken, S., Peter Nugent, Perlmutter, S., Siegrist, J., Scalzo, R., Thomas, R. C., Wang, L., Adam, G., Bacon, R., Bonnaud, C., Capoani, L., Dubet, D., Henault, F., Lantz, B., Lemonnier, J. -P, Pecontal, A., Pecontal, E., Blanc, N., Boudoul, G., Bongard, S., Castera, A., Copin, Y., Gangler, E., Sauge, L., Smadja, G., Kessler, R., Antilogus, P., Astier, P., Barrelet, E., Garavini, G., Gilles, S., Guevara, L. -A, Imbault, D., Juramy, C., Pain, R., Taillet, R., Vincent, D., Baltay, C., Rabinowitz, D., and Bauer, A.

28. Leucism in Mexican small-eared shrew Cryptotis mexicana (Mammalia: Soricomorpha), endemic to Mexico | Leucismo en la musaraña de orejas cortas Cryptotis mexicana (Mammalia: Soricomorpha), endémica de México

Author: Guevara, L., Héctor Emilio Ramírez Chaves, and Cervantes, F. A.

29. Length-weight relationship and condition factor of butterfish Peprilus medius (Peters, 1869) in the southeast Gulf of California

Author: Los Angeles Maldonado-Amparo, M., Sanchez-Cardenas, R., Salcido-Guevara, L. A., Valdez-Pineda, M. C., Ramirez-Perez, J. S., Arzola-González, J. F., Moreno-Sánchez, X. G., and Emigdio Marín-Enríquez

30. Type determination for SN 2004M

Author: Aldering, G., Lee, B. C., Loken, S., Peter Nugent, Perlmutter, S., Siegrist, J., Scalzo, R., Thomas, R. C., Wang, L., Adam, G., Bacon, R., Bonnaud, C., Capoani, L., Dubet, D., Henault, F., Lantz, B., Lemonnier, J. -P, Pecontal, A., Pecontal, E., Blanc, N., Boudoul, G., Bongard, S., Castera, A., Copin, Y., Gangler, E., Sauge, L., Smadja, G., Kessler, R., Antilogus, P., Astier, P., Barrelet, E., Garavini, G., Gilles, S., Guevara, L. -A, Imbault, D., Juramy, C., Pain, R., Taillet, R., Vincent, D., Baltay, C., Rabinowitz, D., and Bauer, A.

31. Correction to ATEL #396: Type determination for SN 2005M: The Nearby Supernova Factory

Author: Aldering, G., Lee, B. C., Loken, S., Peter Nugent, Perlmutter, S., Siegrist, J., Scalzo, R., Thomas, R. C., Wang, L., Adam, G., Bacon, R., Bonnaud, C., Capoani, L., Dubet, D., Henault, F., Lantz, B., Lemonnier, J. -P, Pecontal, A., Pecontal, E., Blanc, N., Boudoul, G., Bongard, S., Castera, A., Copin, Y., Gangler, E., Sauge, L., Smadja, G., Kessler, R., Antilogus, P., Astier, P., Barrelet, E., Garavini, G., Gilles, S., Guevara, L. -A, Imbault, D., Juramy, C., Pain, R., Taillet, R., Vincent, D., Baltay, C., Rabinowitz, D., and Bauer, A.

32. AGATA-Advanced GAmma Tracking Array

Author: A. Colombo, Y. Mariette, A. Johnson, W. Korten, A. Brondi, T. Faul, J. Robin, R. Depalo, M. Slee, J. Gre¸bosz, H. C. Boston, H. Harroch, B. Rossé, M. Filliger, M. Gulmini, A. Korichi, S. Brambilla, J.R. Cresswell, C. Parisel, P. Edelbruck, F. Ameil, F. Camera, C. Oziol, Matthew Richard Dimmock, G. Salvato, F. Morbiducci, J. Ropert, M. Borsato, E. Legay, Marco Bellato, C. Santos, Gheorghe Pascovici, L. Charles, J. Pancin, G. Casati, P. G. Bizzeti, T. Stanios, S. Lhenoret, Diego Barrientos, P.M. Jones, Andreas Görgen, V. Chambert, S. Aydin, K. Hauschild, B. Hervieu, R. Nicolini, J. Simpson, H. J. Wollersheim, L. Lavergne, Pär-Anders Söderström, G. S. Simpson, G. Jaworski, F. Filmer, R. Griffiths, P.S. Morrall, M. Petcu, G. Lo Bianco, D. Linget, A. Givechev, D. C. Oxley, M. Kogimtzis, F. Salomon, J. Jolie, D. Wells, S. Moon, C. Aufranc, A. Corsi, T. Descombes, N. Goel, J. Thornhill, N. Warr, Serkan Akkoyun, B. Birkenbach, F. Dorangeville, Joël Chavas, P. Medina, Roberto Isocrate, C. Weber, E. Merchan, Bo Cederwall, I. Kojouharov, Enrique Sanchis, A. Lopez-Martens, Oliver Wieland, F. Le Blanc, D. Seddon, S. C. Letts, D. Bazzacco, J. Leske, B. Bruyneel, Alberto Pullia, L. Nelson, G. La Rana, B. Travers, I. Burrows, G. Maron, S. Coelli, J. J. Valiente-Dobón, F. Saillant, Piotr Bednarczyk, V.L. Ngo, J. Mierzejewski, Norbert Pietralla, R.S. Kempley, N. Kurz, M. Rebeschini, S. Fantinel, D. L. Balabanski, A. J. Boston, F. Tomasi, R. Berthier, M. D. Salsac, B. Dulny, C. Stahl, N. Dosme, C. Fanin, R. Baumann, S. Pietri, A. Astier, M. Nicoletto, J. van der Marel, A. Bracco, Björn Jonson, D. Mengoni, D. Bloor, Luna Pellegri, F. Lefebvre, D. Pugnére, J. Egea, S. Cabaret, D. Curien, M. Reese, C. Commeaux, Dirk Rudolph, A. Giannatiempo, F. Recchia, L. Ramina, A. Lermitage, C. A. Ur, R. M. Lieder, I.P. Brawn, R. Menegazzo, R. Raine, Krasimir Mitev, D. R. Napoli, G. Suliman, M. Kebbiri, Y. Drouen, Susan Rigby, W. Me¸czyński, R. Wadsworth, F. Didierjean, P. Desesquelles, Ch. Veyssiere, S. Leoni, Vicente González, P. Gros, Y. Le Noa, M. Castoldi, O. Möller, R. Orlandi, Thomas Beck, M. Şenyiğit, A. Jungclaus, L. Gibelin, Mohammed Kaci, Zs. Podolyák, J. Gerl, S. Erturk, W. Gast, B. Melon, V. Mendéz, R. Peghin, P. Molini, M. N. Erduran, D. Conventi, Pankaj S. Joshi, E. Clément, F.A. Beck, A. Austin, A. Cortesi, J. Palin, P. Cocconi, L. J. Harkness, F. C. L. Crespi, Dirk Weisshaar, P. Sona, A. Czermak, D. Lersch, N. Blasi, Anton Khaplanov, O. Stezowski, B. Rubio, R. Venturelli, M.-H. Sigward, E. Viscione, José Salt, C. S. Özben, Giancarlo Ripamonti, P. Spolaore, Johan Nyberg, S. M. Lenzi, L. Legeard, N. Redon, C. Rossi Alvarez, C. He, R. Chapman, P. Le Pouhalec, C. Diarra, Herbert Hess, T. Engert, A. Kaşkaş, Stanislav Tashenov, S. Klupp, C. Michelagnoli, Elif Ince, A. Algora, J. F. Smith, M. Ozille, Alessandro Zucchiatti, Angelo Geraci, A. Olariu, M. Labiche, N. Karkour, Stefano Riboldi, P. Bourgault, C. M. Petrache, M. Palacz, M. El Chambit, J.-L. Cercus, M. Zie¸bliński, Alex Wiens, R. Beunard, X. Lafay, T. Habermann, M. Karolak, L. Costa, Y. Aubert, Begoña Quintana, A P Robinson, V. F. E. Pucknell, D. Rosso, A. Capsoni, Emanuele Vardaci, L. Mihailescu, M. Tripon, E. Farnea, Ch. Theisen, Enrico Calore, G. Duchêne, N. V. Zamfir, X. Grave, S. Lunardi, I.H. Lazarus, José Blasco, D. Montanari, J.A. Sampson, P. H. Regan, N. Marginean, M. Pignanelli, L. Arnold, G. Benzoni, R. Krücken, G. de Angelis, D.P. Scraggs, I. Piqueras, D. M. Cullen, A. Obertelli, A. Bürger, D. Bortolato, G. Rainovski, A.R. Mather, P. Reiter, C. Unsworth, G. Baulieu, P. J. Coleman-Smith, C. Boiano, M. Richer, Sébastien Perrier, Agnese Giaz, Reynold J. Cooper, V. Vandone, S. Tanguy, C. Domingo-Pardo, A. Bouty, A. N. Grint, A. Maj, A. Gottardo, L. Berti, E. Pachoud, R. Marginean, E. A. Stefanova, A. Triossi, M. Nespolo, D. Bucurescu, R. Moro, H.T.M. Ha, D. S. Judson, J. L. Tain, A. Perego, Francesco Lelli, P. Detistov, B.Y. Ky, J. Ljungvall, B. Sowicki, M. Schlarb, F. Azaiez, P. Pariset, Ertan Şahin, R. Gernhäuser, M. Turcato, John Paul Strachan, B. Million, A. Atac, F. Carrio, D. Delbourg, F. Veronese, Th. Kröll, B. Cahan, A. Hernandez-Prieto, M. A. Bentley, K.M.M. Tun-Lanoë, B. Alikhani, P. Boutachkov, S. Leboutelier, Maria Doncel, A. M. Bizzeti-Sona, R. Touzery, A. Nannini, A. Lotode, P. J. Nolan, G. Rampazzo, F. Zocca, H. Schaffner, J. Eberth, A. Gadea, N. Toniolo, T. Hüyük, Q.T. Doan, P. Petkov, S. Broussard, S. Badoer, M. Rigato, Philip M Walker, J. Pouthas, Ch. Finck, L. Milechina, M. Norman, E. Pierre, J. Roccaz, S.J. Colosimo, Lázaro Guevara, Glyn Wittwer, Millan, Vicente Gonzalez -- 0000-0001-6014-2586, Rainovski, Georgi -- 0000-0002-1729-0249, Jaworski, Grzegorz -- 0000-0003-2241-0329, KORTEN, Wolfram -- 0000-0002-3940-0816, Domingo-Pardo, Cesar -- 0000-0002-2915-5466, Triossi, Andrea -- 0000-0001-5140-9154, Huyuk, Tayfun -- 0000-0003-0597-9767, Ince, Elif -- 0000-0003-4821-5441, Algora, Alejandro -- 0000-0002-5199-1794, Calore, Enrico -- 0000-0002-2301-3838, Rubio, Berta -- 0000-0002-9149-4151, THEISEN, Christophe -- 0000-0002-8509-1022, Rudolph, Dirk -- 0000-0003-1199-3055, Gadea, Andres -- 0000-0002-4233-1970, santos, cayetano -- 0000-0003-0727-1914, nannini, adriana -- 0000-0003-0659-7648, Depalo, Rosanna -- 0000-0003-3943-7982, Suliman, gabriel -- 0000-0001-8475-1992, Blasco, Jose-Maria -- 0000-0002-7663-9092, Petrache, Costel -- 0000-0001-8419-1390, Pietralla, Norbert -- 0000-0002-4797-3032, Cederwall, Bo -- 0000-0003-1771-2656, Zucchiatti, Alessandro -- 0000-0002-3647-596X, Mendez Munoz, Victor -- 0000-0002-9044-1189, Kruecken, Reiner -- 0000-0002-2755-8042, Napoli, Daniel Ricardo -- 0000-0002-8154-6958, Tain, Jose L. -- 0000-0002-3263-6965, SANCHIS, ENRIQUE -- 0000-0002-9689-9131, Zieblinski, Miroslaw -- 0000-0002-8693-7317, Hauschild, Karl -- 0000-0003-2862-2445, Montanari, Daniele -- 0000-0002-1980-7686, senyigit, menekse -- 0000-0002-2408-4419, La Rana, Giovanni -- 0000-0003-2814-4113, Menegazzo, Roberto -- 0000-0002-3060-5276, Soderstrom, Par-Anders -- 0000-0002-9504-2814, Unsworth, Carl -- 0000-0002-4100-7466, Camera, Franco -- 0000-0003-1731-4834, Gorgen, Andreas -- 0000-0003-1916-9941, Hernandez Prieto, Alvaro -- 0000-0002-0340-0240, Recchia, Francesco -- 0000-0002-8428-0112, de France, Gilles -- 0000-0002-7439-1759, GOTTARDO, Andrea -- 0000-0002-0390-5767, Perrier, Sebastien -- 0000-0001-5055-9046, Sowicki, Bogdan -- 0000-0002-7208-0690, Robinson, Andrew -- 0000-0002-2510-1321, Sahin, Eda -- 0000-0003-0683-5140, Pullia, Alberto -- 0000-0002-6393-747X, Lelli, Francesco -- 0000-0003-1900-9171, Clement, Emmanuel -- 0000-0003-1887-717X, benzoni, giovanna -- 0000-0002-7938-0338, Jonson, Bjorn -- 0000-0002-9697-9115, Bednarczyk, Piotr -- 0000-0002-5699-5292, Jones, Pete -- 0000-0001-7480-6603, Nicoletto, Marino -- 0000-0001-9301-0782, Ripamonti, Giancarlo -- 0000-0002-9406-021X, Bentley, Michael -- 0000-0001-8401-3455, Pellegri, Luna -- 0000-0002-3227-3332, Barrientos, Diego -- 0000-0001-9693-2942, GIAZ, Agnese -- 0000-0002-2550-450X, [Boston, A. J. -- Boston, H. C. -- Colosimo, S. -- Cooper, R. J. -- Cresswell, J. R. -- Dimmock, M. R. -- Filmer, F. -- Grint, A. N. -- Harkness, L. J. -- Judson, D. S. -- Mather, A. R. -- Moon, S. -- Nelson, L. -- Nolan, P. J. -- Norman, M. -- Oxley, D. C. -- Rigby, S. -- Sampson, J. -- Scraggs, D. P. -- Seddon, D. -- Slee, M. -- Stanios, T. -- Thornhill, J. -- Unsworth, C. -- Wells, D.] Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England -- [Akkoyun, S. -- Atac, A. -- Kaskas, A. -- Senyigit, M.] Ankara Univ, Fac Sci, Dept Phys, TR-06100 Ankara, Turkey -- [Algora, A. -- Barrientos, D. -- Domingo-Pardo, C. -- Egea, J. -- Gadea, A. -- Hueyuek, T. -- Kaci, M. -- Mendez, V. -- Rubio, B. -- Salt, J. -- Tain, J. L.] Univ Valencia, CSIC, IFIC, E-46980 Paterna, Spain -- [Alikhani, B. -- Boutachkov, P. -- Givechev, A. -- Goel, N. -- Leske, J. -- Merchan, E. -- Moeller, O. -- Pietralla, N. -- Reese, M. -- Stahl, C.] Tech Univ Darmstadt, IKP, D-64289 Darmstadt, Germany -- [Ameil, F. -- Beck, T. -- Boutachkov, P. -- Domingo-Pardo, C. -- Engert, T. -- Gerl, J. -- Goel, N. -- Habermann, T. -- Kojouharov, I. -- Kurz, N. -- Merchan, E. -- Pietri, S. -- Schaffner, H. -- Tashenov, S. -- Wollersheim, H. J.] GSI Helmholtzzentrum Schwerionenforsch GmbH, D-64291 Darmstadt, Germany -- [de Angelis, G. -- Badoer, S. -- Berti, L. -- Calore, E. -- Cocconi, P. -- Conventi, D. -- Costa, L. -- Fantinel, S. -- Gadea, A. -- Gottardo, A. -- Gulmini, M. -- He, C. -- Ince, E. -- Kroell, Th. -- Lelli, F. -- Maron, G. -- Molini, P. -- Napoli, D. R. -- Rigato, M. -- Rosso, D. -- Sahin, E. -- Spolaore, P. -- Toniolo, N. -- Valiente-Dobon, J. J.] Ist Nazl Fis Nucl, Lab Nazl Legnaro, IT-35020 Padua, Italy -- [Arnold, L. -- Baumann, R. -- Beck, F. A. -- El Chambit, M. -- Charles, L. -- Curien, D. -- Didierjean, F. -- Duchene, G. -- Faul, T. -- Filliger, M. -- Finck, Ch. -- Medina, P. -- Pachoud, E. -- Parisel, C. -- Piqueras, I. -- Richer, M. -- Robin, J. -- Santos, C. -- Sigward, M. -H. -- Weber, C.] Univ Strasbourg, IPHC, F-67037 Strasbourg, France -- [Arnold, L. -- Baumann, R. -- Beck, F. A. -- El Chambit, M. -- Charles, L. -- Curien, D. -- Didierjean, F. -- Duchene, G. -- Faul, T. -- Filliger, M. -- Finck, Ch. -- Medina, P. -- Pachoud, E. -- Parisel, C. -- Piqueras, I. -- Richer, M. -- Robin, J. -- Santos, C. -- Sigward, M. -H. -- Weber, C.] CNRS, UMR 7178, F-67037 Strasbourg, France -- [Astier, A. -- Cabaret, S. -- Desesquelles, P. -- Dosme, N. -- Gibelin, L. -- Ha, H. T. M. -- Hauschild, K. -- Karkour, N. -- Korichi, A. -- Lafay, X. -- Leboutelier, S. -- Legay, E. -- Lhenoret, S. -- Linget, D. -- Ljungvall, J. -- Lopez-Martens, A. -- Morbiducci, F. -- Ngo, V. L. -- Pariset, P. -- Perrier, S. -- Pierre, E. -- Roccaz, J. -- Travers, B.] Univ Paris 11, CNRS, IN2P3, CSNSM, F-91405 Orsay, France -- [Atac, A. -- Nyberg, J. -- Soderstrom, P. -A.] Uppsala Univ, Dept Phys & Astron, Uppsala, Sweden -- [Atac, A. -- Cederwall, B. -- Johnson, A. -- Khaplanov, A. -- van der Marel, J. -- Milechina, L. -- Tashenov, S.] Royal Inst Technol, SE-10691 Stockholm, Sweden -- [Aubert, Y. -- Azaiez, F. -- Le Blanc, F. -- Cercus, J. -L. -- Chambert, V. -- Commeaux, C. -- Delbourg, D. -- Diarra, C. -- Dorangeville, F. -- Edelbruck, P. -- Grave, X. -- Guevara, L. -- Harroch, H. -- Ky, B. Y. -- Lavergne, L. -- Lefebvre, F. -- Lermitage, A. -- Olariu, A. -- Oziol, C. -- Petrache, C. -- Pouthas, J. -- Salomon, F. -- Tanguy, S. -- Tun-Lanoe, K. M. M.] Univ Paris 11, CNRS, IN2P3, IPNO, F-91406 Orsay, France -- [Aufranc, C. -- Baulieu, G. -- Doan, Q. T. -- Pugnere, D. -- Redon, N. -- Rosse, B. -- Stezowski, O.] Univ Lyon 1, CNRS, IN2P3, Inst Phys Nucl Lyon, F-69622 Villeurbanne, France -- [Austin, A. -- Burrows, I. -- Coleman-Smith, P. J. -- Griffiths, R. -- Kogimtzis, M. -- Labiche, M. -- Lazarus, I. H. -- Letts, S. C. -- Morrall, P. S. -- Palin, J. -- Pucknell, V. F. E. -- Simpson, J. -- Strachan, J.] STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England -- [Aydin, S. -- Bazzacco, D. -- Bellato, M. -- Bortolato, D. -- Chavas, J. -- Colombo, A. -- Fanin, C. -- Farnea, E. -- Isocrate, R. -- Kroell, Th. -- Lenzi, S. M. -- Lunardi, S. -- Marginean, R. -- Menegazzo, R. -- Mengoni, D. -- Michelagnoli, C. -- Nespolo, M. -- Nicoletto, M. -- Peghin, R. -- Ramina, L. -- Rampazzo, G. -- Rebeschini, M. -- Recchia, F. -- Rossi Alvarez, C. -- Salvato, G. -- Triossi, A. -- Turcato, M. -- Ur, C. A. -- Venturelli, R. -- Veronese, F.] Ist Nazl Fis Nucl, Sez Padova, IT-35131 Padua, Italy -- [Balabanski, D. L. -- Detistov, P. -- Petkov, P. -- Stefanova, E.] Bulgarian Acad Sci, Inst Nucl Res & Nucl Energy, Sofia, Bulgaria -- [Bednarczyk, P. -- Czermak, A. -- Dulny, B. -- Grebosz, J. -- Maj, A. -- Meczynski, W. -- Sowicki, B. -- Zieblinski, M.] Polish Acad Sci, Henryk Niewodniczanski Inst Nucl Phys, PL-31342 Krakow, Poland -- [Bentley, M. A. -- Bloor, D. -- Joshi, P. -- Wadsworth, R.] Univ York, Dept Phys, York YO10 5DD, N Yorkshire, England -- [Benzoni, G. -- Blasi, N. -- Boiano, C. -- Bracco, A. -- Brambilla, S. -- Camera, F. -- Capsoni, A. -- Casati, G. -- Coelli, S. -- Corsi, A. -- Cortesi, A. -- Crespi, F. C. L. -- Geraci, A. -- Giaz, A. -- Leoni, S. -- Million, B. -- Montanari, D. -- Nicolini, R. -- Pellegri, L. -- Pignanelli, M. -- Pullia, A. -- Riboldi, S. -- Ripamonti, G. -- Tomasi, F. -- Vandone, V. -- Viscione, E. -- Wieland, O. -- Zocca, F.] Ist Nazl Fis Nucl, Sez Milano, IT-20133 Milan, Italy -- [Berthier, R. -- Bouty, A. -- Broussard, S. -- Buerger, A. -- Drouen, Y. -- Gros, P. -- Goergen, A. -- Hervieu, B. -- Karolak, M. -- Kebbiri, M. -- Korten, W. -- Ljungvall, J. -- Lotode, A. -- Mariette, Y. -- Le Noa, Y. -- Obertelli, A. -- Le Pouhalec, P. -- Salsac, M. -D. -- Theisen, Ch. -- Touzery, R. -- Veyssiere, Ch.] CEA, Ctr Saclay, IRFU, F-91191 Gif Sur Yvette, France -- [Beunard, R. -- Bourgault, P. -- Cahan, B. -- Clement, E. -- de France, G. -- Legeard, L. -- Ozille, M. -- Pancin, J. -- Raine, R. -- Ropert, J. -A. -- Saillant, F. -- Tripon, M. -- Wittwer, G.] CEA DSM CNRS IN2P3, GANIL, F-14076 Caen, France -- [Birkenbach, B. -- Bruyneel, B. -- Eberth, J. -- Hess, H. -- Jolie, J. -- Lersch, D. -- Pascovici, G. -- Reiter, P. -- Warr, N. -- Weisshaar, D. -- Wiens, A.] Univ Cologne, IKP, D-50937 Cologne, Germany -- [Bizzeti, P. G. -- Bizzeti-Sona, A. M. -- Giannatiempo, A. -- Melon, B. -- Perego, A. -- Sona, P.] Univ Florence, Dipartimento Fis & Astron, IT-50019 Florence, Italy -- [Bizzeti, P. G. -- Bizzeti-Sona, A. M. -- Giannatiempo, A. -- Melon, B. -- Nannini, A. -- Perego, A. -- Sona, P.] Ist Nazl Fis Nucl, Sez Firenze, IT-50019 Florence, Italy -- [Blasco, J. M. -- Carrio, F. -- Egea, J. -- Gonzalez, V. -- Sanchis, E.] Univ Valencia, Dept Elect Engn, E-46100 Burjassot, Valencia, Spain -- [Borsato, M. -- Bortolato, D. -- Lenzi, S. M. -- Lunardi, S. -- Marginean, R. -- Mengoni, D. -- Michelagnoli, C. -- Nespolo, M. -- Recchia, F. -- Salvato, G. -- Triossi, A. -- Venturelli, R.] Univ Padua, Dipartimento Fis, IT-35131 Padua, Italy -- [Bracco, A. -- Camera, F. -- Corsi, A. -- Crespi, F. C. L. -- Giaz, A. -- Leoni, S. -- Montanari, D. -- Nicolini, R. -- Pellegri, L. -- Pignanelli, M. -- Pullia, A. -- Riboldi, S. -- Vandone, V.] Univ Milan, Dipartimento Fis, IT-20133 Milan, Italy -- [Brawn, I. P.] STFC Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England -- [Brondi, A. -- Moro, R. -- La Rana, G. -- Vardaci, E.] Univ Naples Federico II, Dipartimento Fis, IT-80126 Naples, Italy -- [Brondi, A. -- Moro, R. -- La Rana, G. -- Vardaci, E.] Ist Nazl Fis Nucl, Sez Napoli, IT-80126 Naples, Italy -- [Bucurescu, D. -- Marginean, N. -- Marginean, R. -- Petcu, M. -- Ur, C. A.] Natl Inst Phys & Nucl Engn, Bucharest, Romania -- [Buerger, A. -- Suliman, G. -- Zamfir, N. V.] Univ Bonn, Helmholtz Inst Strahlen & Kernphys, D-53115 Bonn, Germany -- [Buerger, A.] Univ Oslo, Dept Phys, N-0316 Oslo, Norway -- [Casati, G. -- Geraci, A. -- Ripamonti, G.] Politecn Milan, Dipartimento Elettron & Informaz, IT-20133 Milan, Italy -- [Castoldi, M. -- Zucchiatti, A.] Ist Nazl Fis Nucl, Sez Genova, IT-16146 Genoa, Italy -- [Chapman, R. -- Mengoni, D. -- Orlandi, R. -- Smith, J. F.] Univ W Scotland, Sch Engn, Paisley PA1 2BE, Renfrew, Scotland -- [Cullen, D. M. -- Robinson, A. P.] Univ Manchester, Sch Phys & Astron, Schuster Lab, Manchester M13 9PL, Lancs, England -- [Depalo, R.] Univ Padua, Dipartimento Astron, IT-35131 Padua, Italy -- [Descombes, T. -- Simpson, G.] Univ Grenoble 1, CNRS, IN2P3, LPSC,INP Grenoble, F-38026 Grenoble, France -- [Doncel, M. -- Hernandez-Prieto, A. -- Quintana, B.] Univ Salamanca, Dept Fis Fundamental, E-37008 Salamanca, Spain -- [Erduran, M. N. -- Ince, E.] Istanbul Univ, Istanbul, Turkey -- [Erturk, S.] Nigde Univ, Fac Sci, Dept Phys, TR-51200 Nigde, Turkey -- [Gast, W. -- Lieder, R. M. -- Mihailescu, L.] Forschungszentrum Julich, Inst Kernphys, D-52425 Julich, Germany -- [Gernhaeuser, R. -- Klupp, S. -- Kruecken, R. -- Schlarb, M.] Tech Univ Munich, Phys Dept E12, D-85748 Garching, Germany -- [Jaworski, G.] Warsaw Univ Technol, Fac Phys, PL-00662 Warsaw, Poland -- [Jaworski, G. -- Mierzejewski, J. -- Palacz, M.] Univ Warsaw, Heavy Ion Lab, PL-02093 Warsaw, Poland -- [Jones, P.] Univ Jyvaskyla, Dept Phys, FI-40014 Jyvaskyla, Finland -- [Jonson, B.] Chalmers, S-41296 Gothenburg, Sweden -- [Jungclaus, A. -- Orlandi, R.] CSIC, Inst Estruct Mat, E-28006 Madrid, Spain -- [Kempley, R. S. -- Podolyak, Z. -- Regan, P. H. -- Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England -- [Mitev, K. -- Rainovski, G.] Sofia Univ St Kliment Ohridski, Fac Phys, Sofia, Bulgaria -- [Ozben, C.] Istanbul Tech Univ, TR-80626 Istanbul, Turkey -- [Rudolph, D.] Lund Univ, Dept Phys, SE-22100 Lund, Sweden, Research Group: Information Management, CSNSM SNO, Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), informatique, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CSNSM MECA, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), CSNSM INFOR, CSNSM ELEC, Matière Nucléaire, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), AGATA, Akkoyun, S., Algora, A., Alikhani, B., Ameil, F., De Angelis, G, Arnold, L., Astier, A., Ataç, A., Aubert, Y., Aufranc, C., Austin, A., Aydin, S., Azaiez, F., Badoer, S., Balabanski, D. L., Barrientos, D., Baulieu G., L, Baumann, R., Bazzacco, D., Beck, F. A., Beck, T., Bednarczyk, P., Bellato, M., Bentley, M. A., Benzoni, G., Berthier, R., Berti, L., Beunard, R., Lo Bianco, G., Birkenbach, B., Bizzeti, P. G., Bizzeti Sona, A. M., Le Blanc, F., Blasco, J. M., Blasi, N., Bloor, D., Boiano, C., Borsato, M., Bortolato, D., Boston, A. J., Boston, H. C., Bourgault, P., Boutachkov, P., Bouty, A., Bracco, A., Brambilla, S., Brawn, I. P., Brondi, Augusto, Broussard, S., Bruyneel, B., Bucurescu, D., Burrows, I., Bürger, A., Cabaret, S., Cahan, B., Calore, E., Camera, F., Capsoni, A., Carrió, F., Casati, G., Castoldi, M., Cederwall, B., Cercus J., L, Chambert, V., El Chambit, M., Chapman, R., Charles, L., Chavas, J., Clément, E., Cocconi, P., Coelli, S., Coleman Smith, P. J., Colombo, A., Colosimo, S., Commeaux, C., Conventi, D., Cooper, R. J., Corsi, A., Cortesi, A., Costa, L., Crespi, F. C. L., Cresswell, J. R., Cullen, D. M., Curien, D., Czermak, A., Delbourg, D., Depalo, R., Descombes, T., Désesquelles, P., Detistov, P., Diarra, C., Didierjean, F., Dimmock, M. R., Doan, Q. T., Domingo Pardo, C., Doncel, M., Dorangeville, F., Dosme, N., Drouen, Y., Duchêne, G., Dulny, B., Eberth, J., Edelbruck, P., Egea, J., Engert, T., Erduran, M. N., Ertürk, S., Fanin, C., Fantinel, S., Farnea, E., Faul, T., Filliger, M., Filmer, F., Finck, C., De France, G., Gadea, A., Gast, W., Geraci, A., Gerl, J., Gernhäuser, R., Giannatiempo, A., Giaz, A., Gibelin, L., Givechev, A., Goel, N., González, V., Gottardo, A., Grave, X., Grȩbosz, J., Griffiths, R., Grint, A. N., Gros, P., Guevara, L., Gulmini, M., Görgen, A., Ha, H. T. M., Habermann, T., Harkness, L. J., Harroch, H., Hauschild, K., He, C., Hernández Prieto, A., Hervieu, B., Hess, H., Hüyük, T., Ince, E., Isocrate, R., Jaworski, G., Johnson, A., Jolie, J., Jones, P., Jonson, B., Joshi, P., Judson, D. S., Jungclaus, A., Kaci, M., Karkour, N., Karolak, M., Kaşkaş, A., Kebbiri, M., Kempley, R. S., Khaplanov, A., Klupp, S., Kogimtzis, M., Kojouharov, I., Korichi, A., Korten, W., Kröll, T., Krücken, R., Kurz, N., Ky, B. Y., Labiche, M., Lafay, X., Lavergne, L., Lazarus, I. H., Leboutelier, S., Lefebvre, F., Legay, E., Legeard, L., Lelli, F., Lenzi, S. M., Leoni, S., Lermitage, A., Lersch, D., Leske, J., Letts, S. C., Lhenoret, S., Lieder, R. M., Linget, D., Ljungvall, J., Lopez Martens, A., Lotodé, A., Lunardi, S., Maj, A., Van Der Marel, J., Mariette, Y., Marginean, N., Marginean, R., Maron, G., Mather, A. R., Mȩczyński, W., Mendéz, V., Medina, P., Melon, B., Menegazzo, R., Mengoni, D., Merchan, E., Mihailescu, L., Michelagnoli, C., Mierzejewski, J., Milechina, L., Million, B., Mitev, K., Molini, P., Montanari, D., Moon, S., Morbiducci, F., Moro, RENATA EMILIA MARIA, Morrall, P. S., Möller, O., Nannini, A, Napoli, D. R., Nelson, L., Nespolo, M., Ngo, V. L., Nicoletto, M., Nicolini, R., Le Noa, Y., Nolan, P. J., Norman, M., Nyberg, J., Obertelli, A., Olariu, A., Orlandi, R., Oxley, D. C., Özben, C., Ozille, M., Oziol, C., Pachoud, E., Palacz, M., Palin, J., Pancin, J., Parisel, C., Pariset, P., Pascovici, G., Peghin, R., Pellegri, L., Perego, A., Perrier, S., Petcu, M., Petkov, P., Petrache, C., Pierre, E., Pietralla, N., Pietri, S., Pignanelli, M., Piqueras, I., Podolyak, Z., Le Pouhalec, P., Pouthas, J., Pugnére D., L, Pucknell, V. F. E., Pullia, A., Quintana, B., Raine, R., Rainovski, G., Ramina, L., Rampazzo, G., LA RANA, Giovanni, Rebeschini, M., Recchia, F., Redon N., L, Reese M., C, Reiter, P., Regan, P. H., Riboldi, S., Richer, M., Rigato, M., Rigby, S., Ripamonti, G., Robinson, A., Robin, J., Roccaz, J., Ropert, J. A., Rossé, B. l., Rossi Alvarez, C., Rosso, D., Rubio, B., Rudolph, D., Saillant, F., Şahin, E., Salomon, F., Salsac, M. D., Salt, J., Salvato, G., Sampson, J., Sanchis, E., Santos, C., Schaffner, H., Schlarb, M., Scraggs, D. P., Seddon, D., Şenyiǧit, M., Sigward, M. H., Simpson, G., Simpson, J., Slee, M., Smith, J. F., Sona, P., Sowicki, B., Spolaore, P., Stahl, C., Stanios, T., Stefanova, E., Stézowski, O., Strachan, J., Suliman, G., Söderström, P. A., Tain, J. L., Tanguy, S., Tashenov, S., Theisen, C. h., Thornhill, J., Tomasi, F., Toniolo, N., Touzery, R., Travers, B., Triossi, A., Tripon, M., Tun Lanoë, K. M. M., Turcato, M., Unsworth, C., Ur, C. A., Valiente Dobon, J. J., Vandone, V., Vardaci, Emanuele, Venturelli, R., Veronese, F., Veyssiere, C., Viscione, E., Wadsworth, R., Walker, P. M., Warr, N., Weber, C., Weisshaar, D., Wells, D., Wieland, O., Wiens A., U, Wittwer, G., Wollersheim, H. J., Zocca, F., Zamfir, N. V., Ziȩbliński, M., Zucchiatti, A., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and 0-Belirlenecek
Subjects: Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Pulse-shape and gamma-ray tracking algorithms, FOS: Physical sciences, Semiconductor detector performance and simulations, Integrated circuit, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Tracking (particle physics), gamma-Ray tracking, 01 natural sciences, Pulse-shape and γ-ray tracking algorithms, law.invention, Data acquisition, law, 0103 physical sciences, ddc:530, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment (nucl-ex), 010306 general physics, γ-Ray spectroscopy, Nuclear Experiment, Instrumentation, Digital signal processing, Event reconstruction, gamma-Ray spectroscopy, Physics, sezele, Spectrometer, Spectrometers, 010308 nuclear & particles physics, business.industry, Detector, AGATA, Digital signals, HPGe detectors, Pulse-shape, Ray tracking, HPGe detectors, Algorithms, Crystals, Germanium, Semiconductor detectors, Signal processing, Spectrometry, Tracking (position), γ-Ray tracking, Instrumentation and Detectors (physics.ins-det), AGATA, Física nuclear, business, Computer hardware
Abstract: WOS: 000300864200005, The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation gamma-ray spectrometer. AGATA is based on the technique of gamma-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a gamma ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of gamma-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector-response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. (C) 2011 Elsevier B.V. All rights reserved., EU [RII3-CT-2004-506065]; German BMBF [06K-167, 06KY2051]; Swedish Research Council; Knut and Alice Wallenberg Foundation; UK EPSRC Engineering and Physical Sciences Research Council; UK STFC Science and Technology Facilities Council; AWE plc; Scientific and Technological Research Council of Turkey [106T055]; Ankara University [05B4240002]; Polish Ministry of Science and Higher Education [DPN/N190/AGATA/2009]; Spanish MICINN [FPA2008-06419, FPA2009-13377-C02-02]; Spanish Consolider-Ingenio Programme CPAN [CSD2007-00042]; Generalitat Valenciana [PROMETEO/2010/101]; MICINN, Spain; INFN, Italy [AIC10-D-000568]; Science and Technology Facilities Council [ST/F012039/1, ST/J000094/1, ST/F004192/1, ST/J000159/1, ST/I504940/1, NuSTAR, ST/F006950/1, ST/I504916/1, ST/G000670/1, ST/F004060/1, ST/J000051/1, ST/J000108/1, ST/G000670/1 NuSTAR, ST/I504959/1, ST/G000727/1, ST/F004052/1, ST/F004184/1], AGATA and this work is supported by the European funding bodies and the EU Contract RII3-CT-2004-506065, the German BMBF under Grants 06K-167 and 06KY2051, the Swedish Research Council and the Knut and Alice Wallenberg Foundation, UK EPSRC Engineering and Physical Sciences Research Council, UK STFC Science and Technology Facilities Council, AWE plc, Scientific and Technological Research Council of Turkey (Proj. nr. 106T055) and Ankara University (BAP Proj. nr. 05B4240002), the Polish Ministry of Science and Higher Education under Grant DPN/N190/AGATA/2009, the Spanish MICINN under grants FPA2008-06419 and FPA2009-13377-C02-02, the Spanish Consolider-Ingenio 2010 Programme CPAN (contract number CSD2007-00042) the Generalitat Valenciana under Grant PROMETEO/2010/101, and research performed in the frame of the GSI-IN2P3 collaboration agreement number 02-42. A. Gadea and E. Farnea acknowledge the support of MICINN, Spain, and INFN, Italy, through the AIC10-D-000568 bilateral action.
Published: 2012
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