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1. Supplemental Material, sj-pdf-1-tor-10.1177_23978473211021072 - Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis

Author

Langston, T, Randazzo, J, Kogel, U, Hoeng, J, Martin, F, Titz, B, Guedj, E, Schneider, T, Prabhakar, B, Zhang, J, Oldham, M, and Lee, KM

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-pdf-1-tor-10.1177_23978473211021072 for Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis by T Langston, J Randazzo, U Kogel, J Hoeng, F Martin, B Titz, E Guedj, T Schneider, B Prabhakar, J Zhang, M Oldham and KM Lee in Toxicology Research and Application

Published
2021
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2. IDH mutation is paradoxically associated with higher 18F-FDOPA PET uptake in diffuse grade II and grade III gliomas

Author

Figarella‑Branger, Dominique, Verger, A., Metellus, Ph., Sala, Q., Colin, C., Bialecki, E., Taïeb, D., Chinot, O., Figarella-Branger, D., Guedj, E., Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Européen de Recherche en Imagerie médicale (CERIMED), Centre National de la Recherche Scientifique (CNRS)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-École Centrale de Marseille (ECM)-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU), Department of nuclear medicine aphm Timone, Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Department of Neurosurgery Hopital Privé Clairval Marseille, Department of Nuclear Medicine, Hôpital de la Timone [CHU - APHM] (TIMONE), Département de neurooncologie, Institut de Neurosciences de la Timone (INT), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Service Central de Biophysique et de Médecine Nucléaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Privé Clairval [Marseille], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), Neuro-Oncologie [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM] (ACPNP), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Guedj, Eric

Subjects
Oncology, medicine.medical_specialty, Pathology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, Standardized uptake value, 18F-FDopa PET, Newly diagnosed, World health, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, 18f fdopa, [SDV.CAN] Life Sciences [q-bio]/Cancer, Histological diagnosis, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, Stage (cooking), ComputingMilieux_MISCELLANEOUS, business.industry, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, General Medicine, IDH mutation, 3. Good health, Idh mutation, gliomas, prognosis, Who classification, business, 030217 neurology & neurosurgery
Abstract

International audience; Purpose: The World Health Organization Classification of Tumors of the Central Nervous System has recently been updated by the integration of diagnostic and prognostic molecular parameters, giving pivotal attention to IDH mutation as a favourable factor. Amino acid PET is increasingly used in the management of gliomas, but its prognostic value is a matter of debate. The aim of this study was to assess the relationship between IDH mutation and 18F-FDOPA uptake on PET in newly diagnosed gliomas.Methods: A total of 43 patients, presenting with diffuse astrocytic and oligodendroglial grade II and III gliomas, reclassified according to the 2016 WHO classification of tumours of the CNS, were retrospectively included. They had all undergone 18F-FDOPA PET at an initial stage before surgery and histological diagnosis. 18F-FDOPA uptake values were compared between patients with and without IDH mutation in terms of maximum standardized uptake value (SUVmax) ratios between tumour and normal contralateral brain (T/N), and between tumour and striatum (T/S).Results: Patients with IDH mutation showed higher 18F-FDOPA T/N SUVmax ratios (1.6 vs. 1.2) and T/S SUVmax ratios (0.9 vs. 0.6) than patients without IDH mutation (p

Published
2017

3. Incremental value of 18F-florbetaben amyloid PET in the diagnostic work-up of most complex patients with dementia in France: a naturalistic study

Author

Guedj, E., Jonveaux, T., Verger, A., Krolak-Salmon, P., Houzard, C., Godefroy, Olivier, Shields, T., Perrotin, A., Gismondi, R., Bullich, S., Jovalekic, A., Raffa, N., Pasquier, F., Semah, F., Epelbaum, S., Habert, M. O., Wallon, D., Chastan, M., Payoux, P., Stephens, A., Ceccaldi, M., DESSAIVRE, Louise, Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), Service de médecine nucléaire [Marseille], Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service de Gériatrie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Médecine Nucléaire [CHRU Nancy], Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Service de neurologie [Amiens], CHU Amiens-Picardie, Service de Médecine Nucléaire [Amiens], Piramal Imaging, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CATI Multicenter Neuroimaging Platform (CATI), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Toulouse Neuro Imaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

4. Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting

Author

Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappatà S, Marcone A, Garibotto V, CASTIGLIONI I, Magnani G, Cappa SF, Gianolli L, Drzezga A, Perneczky R, Didic M, Guedj E, Van Berckel BN, Ossenkoppele R, Morbelli S, Frisoni G, Caroli A, Radiology and nuclear medicine, NCA - Brain imaging technology, NCA - neurodegeneration, Perani, D, Della Rosa, P, Cerami, C, Gallivanone, F, Fallanca, F, Vanoli, E, Panzacchi, A, Nobili, F, Pappatà, S, Marcone, A, Garibotto, V, Castiglioni, I, Magnani, G, Cappa, S, Gianolli, L, Drzezga, A, Perneczky, R, Didic, M, Guedj, E, Van Berckel, B, Ossenkoppele, R, Morbelli, S, Frisoni, G, Caroli, A, Della Rosa, Pasquale Anthony, Cerami, Chiara, Gallivanone, Francesca, Fallanca, Federico, Vanoli, Emilia Giovanna, Panzacchi, Andrea, Nobili, Flavio, Pappata, Sabina, Marcone, Alessandra, Garibotto, Valentina, Castiglioni, Isabella, Magnani, Giuseppe, Cappa, Stefano, and Gianolli, Luigi

Subjects
NATIONAL INSTITUTE, Male, MILD COGNITIVE IMPAIRMENT, Data Interpretation, Neurology, Statistical Parametrical Mapping, GUIDELINES, lcsh:RC346-429, DISEASE, RECOMMENDATIONS, 030218 nuclear medicine & medical imaging, Computer-Assisted, 0302 clinical medicine, pet, Dementia diagnosis, Nuclear Medicine and Imaging, Diagnosis, 80 and over, F-18-FDG PET, Diagnosis, Computer-Assisted, 10. No inequality, Aged, 80 and over, FDG-PET imaging, Statistical parametrical mapping, Voxel-based analysis, Aged, Brain, Data Interpretation, Statistical, Female, Fluorodeoxyglucose F18, Humans, Middle Aged, Neurodegenerative Diseases, Positron-Emission Tomography, Sensitivity and Specificity, Neurology (clinical), Radiology, Nuclear Medicine and Imaging, Cognitive Neuroscience, Medicine (all), medicine.diagnostic_test, EADC-PET Consortium, GLUCOSE-METABOLISM, ALZHEIMERS ASSOCIATION WORKGROUPS, Statistical, LEWY BODIES, 3. Good health, Positron emission tomography, lcsh:R858-859.7, Radiology, Psychology, Life Sciences & Biomedicine, medicine.medical_specialty, Neuroimaging, Neurodegenerative Diseases/diagnosis, lcsh:Computer applications to medicine. Medical informatics, ddc:616.0757, Article, 03 medical and health sciences, mental disorders, medicine, Dementia, Brain/metabolism, Radiology, Nuclear Medicine and imaging, lcsh:Neurology. Diseases of the nervous system, Science & Technology, business.industry, fungi, Gold standard (test), FRONTOTEMPORAL DEMENTIA, medicine.disease, Positron-Emission Tomography/methods, Clinical diagnosis, Neurosciences & Neurology, Differential diagnosis, Nuclear medicine, business, 030217 neurology & neurosurgery
Abstract

Diagnostic accuracy in FDG-PET imaging highly depends on the operating procedures. In this clinical study on dementia, we compared the diagnostic accuracy at a single-subject level of a) Clinical Scenarios, b) Standard FDG Images and c) Statistical Parametrical (SPM) Maps generated via a new optimized SPM procedure. We evaluated the added value of FDG-PET, either Standard FDG Images or SPM Maps, to Clinical Scenarios. In 88 patients with neurodegenerative diseases (Alzheimer's Disease—AD, Frontotemporal Lobar Degeneration—FTLD, Dementia with Lewy bodies—DLB and Mild Cognitive Impairment—MCI), 9 neuroimaging experts made a forced diagnostic decision on the basis of the evaluation of the three types of information. There was also the possibility of a decision of normality on the FDG-PET images. The clinical diagnosis confirmed at a long-term follow-up was used as the gold standard. SPM Maps showed higher sensitivity and specificity (96% and 84%), and better diagnostic positive (6.8) and negative (0.05) likelihood ratios compared to Clinical Scenarios and Standard FDG Images. SPM Maps increased diagnostic accuracy for differential diagnosis (AD vs. FTD; beta 1.414, p = 0.019). The AUC of the ROC curve was 0.67 for SPM Maps, 0.57 for Clinical Scenarios and 0.50 for Standard FDG Images. In the MCI group, SPM Maps showed the highest predictive prognostic value (mean LOC = 2.46), by identifying either normal brain metabolism (exclusionary role) or hypometabolic patterns typical of different neurodegenerative conditions., Highlights • Brain FDG-PET was evaluated with a new optimized SPM procedure in dementias. • We compared the diagnostic accuracy of clinical information, visual and SPM FDG-PET. • SPM had the best sensitivity (96%), specificity (84%) and positive and negative LR. • In an MCI subgroup, SPM had the highest predictive prognostic value.

Published
2014

5. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Author

Majounie, E1, Renton, Ae, Mok, K, Dopper, Eg, Waite, A, Rollinson, S, Chiò, A, Restagno, G, Nicolaou, N, Simon-Sanchez, J, van Swieten JC, Abramzon, Y, Johnson, Jo, Sendtner, M, Pamphlett, R, Orrell, Rw, Mead, S, Sidle, Kc, Houlden, H, Rohrer, Jd, Morrison, Ke, Pall, H, Talbot, K, Ansorge, O, Hernandez, Dg, Arepalli, S, Sabatelli, M, Mora, G, Corbo, M, Giannini, F, Calvo, A, Englund, E, Borghero, G, Floris, Gl, Remes, Am, Laaksovirta, H, Mccluskey, L, Trojanowski, Jq, Van Deerlin VM, Schellenberg, Gd, Nalls, Ma, Drory, Ve, Lu, Cs, Yeh, Th, Ishiura, H, Takahashi, Y, Tsuji, S, Le Ber, I, Brice, A, Drepper, C, Williams, N, Kirby, J, Shaw, P, Hardy, J, Tienari, Pj, Heutink, P, Morris, Hr, Pickering-Brown, S, Traynor, Bj, Adamson, G, Bayer, Aj, Beck, J, Callister, Jb, Blake, Dj, Blumen, Sc, Collinge, J, Dunckley, T, Ealing, J, East, S, Elman, L, Gerhard, A, Guerreiro, Rj, Gwinn, K, Halliwell, N, Hamdalla, Hh, Hewitt, C, Ince, P, Jablonka, S, James, C, Kent, L, Knock, Jc, Lynch, T, Mahoney, C, Mann, D, Neal, J, Norris, D, O'Dowd, S, Richardson, A, Rossor, M, Rothstein, J, Scholz, Sw, Snowden, J, Stephan, Da, Toulson, G, Turner, Mr, Warren, Jd, Young, K, Weng, Yh, Kuo, Hc, Lai, Sc, Huang, Cl, Camuzat, A, Entraingues, L, Guillot-Noël, Verpillat, P, Blanc, F, Camu, W, Clerget-Darpoux, F, Corcia, P, Couratier, P, Didic, M, Dubois, B, Duyckaerts, C, Guedj, E, Golfier, V, Habert, Mo, Hannequin, D, Lacomblez, L, Meininger, V, Salachas, F, Levy, R, Michel, Bf, Pasquier, F, Puel, M, Thomas-Anterion, C, Sellal, F, Vercelletto, M, Moglia, C, Cammarosano, S, Canosa, A, Gallo, S, Brunetti, M, Ossola, I, Marinou, K, Papetti, L, Pisano, F, Pinter, Gl, Conte, A, Luigetti, M, Zollino, M, Lattante, S, Marangi, G, la Bella, V, Spataro, R, Colletti, T, Battistini, S, Ricci, C, Caponnetto, C, Mancardi, G, Mandich, P, Salvi, F, Bartolomei, I, Mandrioli, J, Sola, P, Lunetta, C, Penco, S, Monsurrò, Mr, Tedeschi, G, Conforti, Fl, Gambardella, A, Quattrone, A, Volanti, P, Floris, G, Cannas, A, Piras, V, Marrosu, F, Marrosu, Mg, Murru, Mr, Pugliatti, M, Parish, Ld, Sotgiu, A, Solinas, G, Ulgheri, L, Ticca, A, Simone, I, Logroscino, G., Neurology, Erasmus MC other, The Chromosome 9-ALS/FTD Consortium, Human genetics, NCA - Neurodegeneration, Università degli studi di Torino (UNITO), Department of Clinical Genetics, Institute for Clinical Neurobiology, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), MRC Prion Unit, UCL Institute of neurology, UCL Institute of Neurology, UCL Institute of Neurology, Queen Square, London, Department of Neuroscience, Catholic University, Roma, Fondazione Maugeri, Department of Neuroscience, University of Siena, Siena, Department of Neurology, Chang Gung Memorial Hospital [Taipei] (CGMH), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, MRC Centre for Neuropsychiatric Genetics and Genomics, Medical Research Council (MRC)-School of Medicine [Cardiff], Cardiff University-Institute of Medical Genetics [Cardiff]-Cardiff University-Institute of Medical Genetics [Cardiff], Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Università degli studi di Torino = University of Turin (UNITO), Julius-Maximilians-Universität Würzburg (JMU), UCL Institute of Neurology, Queen Square [London], Università degli Studi di Siena = University of Siena (UNISI), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
MESH: Signal Transduction, Male, MESH: Vesicular Transport Proteins, MESH: Membrane Glycoproteins, MESH: DNA Repeat Expansion, MESH: Genotype, Cohort Studies, MESH: Protein Structure, Tertiary, MESH: Aged, 80 and over, MESH: Interferon Regulatory Factor-3, 0302 clinical medicine, C9orf72, MESH: Child, MESH: RNA, Small Interfering, 80 and over, genetics, Age of Onset, Child, MESH: Cohort Studies, MESH: Amyotrophic Lateral Sclerosis, MESH: Aged, Genetics, Aged, 80 and over, 0303 health sciences, MESH: Middle Aged, DNA Repeat Expansion, MESH: Toll-Like Receptor 4, Middle Aged, Penetrance, 3. Good health, Settore MED/26 - NEUROLOGIA, Neurology, MESH: Young Adult, MESH: HEK293 Cells, Child, Preschool, Frontotemporal Dementia, Female, Sample collection, Chromosomes, Human, Pair 9, MESH: Myeloid Differentiation Factor 88, Frontotemporal dementia, Human, Pair 9, Adult, MESH: Protein Transport, medicine.medical_specialty, Adolescent, Genotype, MESH: Age of Onset, MESH: RNA Interference, Clinical Neurology, MESH: Frontotemporal Dementia, MESH: Genetic Loci, TARDBP, Chromosomes, 03 medical and health sciences, Open Reading Frames, Young Adult, MESH: Cross-Sectional Studies, Internal medicine, medicine, MESH: Chemokine CCL5, Humans, ddc:610, Preschool, MESH: Adaptor Proteins, Signal Transducing, 030304 developmental biology, Aged, MESH: Adolescent, MESH: Humans, business.industry, MESH: Transfection, MESH: Child, Preschool, Haplotype, Amyotrophic Lateral Sclerosis, MESH: Adult, MESH: Adaptor Proteins, Vesicular Transport, MESH: Open Reading Frames, medicine.disease, MESH: Male, MESH: Cell Line, C9orf72 Protein, Cross-Sectional Studies, MESH: Endosomes, Genetic Loci, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), MESH: Lipopolysaccharides, MESH: Chromosomes, Human, Pair 9, business, Trinucleotide repeat expansion, MESH: Female, Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, genetics, Child, Child, Preschool, Chromosomes, genetics, Cohort Studies, Cross-Sectional Studies, DNA Repeat Expansion, genetics, Female, Frontotemporal Dementia, genetics, Genetic Loci, Genotype, Humans, Male, Middle Aged, Open Reading Frames, genetics, Young Adult, 030217 neurology & neurosurgery
Abstract

International audience; BACKGROUND: We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). METHODS: We screened 4448 patients diagnosed with ALS (El Escorial criteria) and 1425 patients with FTD (Lund-Manchester criteria) from 17 regions worldwide for the GGGGCC hexanucleotide expansion using a repeat-primed PCR assay. We assessed familial disease status on the basis of self-reported family history of similar neurodegenerative diseases at the time of sample collection. We compared haplotype data for 262 patients carrying the expansion with the known Finnish founder risk haplotype across the chromosomal locus. We calculated age-related penetrance using the Kaplan-Meier method with data for 603 individuals with the expansion. FINDINGS: In patients with sporadic ALS, we identified the repeat expansion in 236 (7*0%) of 3377 white individuals from the USA, Europe, and Australia, two (4*1%) of 49 black individuals from the USA, and six (8*3%) of 72 Hispanic individuals from the USA. The mutation was present in 217 (39*3%) of 552 white individuals with familial ALS from Europe and the USA. 59 (6*0%) of 981 white Europeans with sporadic FTD had the mutation, as did 99 (24*8%) of 400 white Europeans with familial FTD. Data for other ethnic groups were sparse, but we identified one Asian patient with familial ALS (from 20 assessed) and two with familial FTD (from three assessed) who carried the mutation. The mutation was not carried by the three Native Americans or 360 patients from Asia or the Pacific Islands with sporadic ALS who were tested, or by 41 Asian patients with sporadic FTD. All patients with the repeat expansion had (partly or fully) the founder haplotype, suggesting a one-off expansion occurring about 1500 years ago. The pathogenic expansion was non-penetrant in individuals younger than 35 years, 50% penetrant by 58 years, and almost fully penetrant by 80 years. INTERPRETATION: A common Mendelian genetic lesion in C9orf72 is implicated in many cases of sporadic and familial ALS and FTD. Testing for this pathogenic expansion should be considered in the management and genetic counselling of patients with these fatal neurodegenerative diseases. FUNDING: Full funding sources listed at end of paper (see Acknowledgments).

Published
2012
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6. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Author

Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, Restagno G, Nicolaou N, Simon Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O, Chromosome 9 ALS/FTD Consortium, French research network on FTLD/FTLD/ALS, ITALSGEN Consortium, Adamson G, Bayer AJ, Beck J, Callister JB, Blake DJ, Blumen SC, Collinge J, Dunckley T, Ealing J, East S, Elman L, Gerhard A, Guerreiro RJ, Gwinn K, Halliwell N, Hamdalla HH, Hewitt C, Ince P, Jablonka S, James C, Kent L, Knock JC, Lynch T, Mahoney C, Mann D, Neal J, Norris D, O'Dowd S, Richardson A, Rossor M, Rothstein J, Scholz SW, Snowden J, Stephan DA, Toulson G, Turner MR, Warren JD, Young K, Weng YH, Kuo HC, Lai SC, Huang CL, Camuzat A, Entraingues L, Guillot Noël, Verpillat P, Blanc F, Camu W, Clerget Darpoux F, Corcia P, Couratier P, Didic M, Dubois B, Duyckaerts C, Guedj E, Golfier V, Habert MO, Hannequin D, Lacomblez L, Meininger V, Salachas F, Levy R, Michel BF, Pasquier F, Puel M, Thomas Anterion C, Sellal F, Vercelletto M, Moglia C, Cammarosano S, Canosa A, Gallo S, Brunetti M, Ossola I, Marinou K, Papetti L, Pisano F, Pinter GL, Conte A, Luigetti M, Zollino M, Lattante S, Marangi G, la Bella V, Spataro R, Colletti T, Battistini S, Ricci C, Caponnetto C, Mancardi G, Mandich P, Salvi F, Bartolomei I, Mandrioli J, Sola P, Lunetta C, Penco S, Conforti FL, Gambardella A, Quattrone A, Volanti P, Floris G, Cannas A, Piras V, Marrosu F, Marrosu MG, Murru MR, Pugliatti M, Parish LD, Sotgiu A, Solinas G, Ulgheri L, Ticca A, Simone I, Logroscino G, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E, Borghero G, Floris GL, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu CS, Yeh TH, Ishiura H, Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shaw P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering Brown S, Traynor BJ, MONSURRO', Maria Rosaria, TEDESCHI, Gioacchino, Majounie, E, Renton, Ae, Mok, K, Dopper, Eg, Waite, A, Rollinson, S, Chiò, A, Restagno, G, Nicolaou, N, Simon Sanchez, J, van Swieten, Jc, Abramzon, Y, Johnson, Jo, Sendtner, M, Pamphlett, R, Orrell, Rw, Mead, S, Sidle, Kc, Houlden, H, Rohrer, Jd, Morrison, Ke, Pall, H, Talbot, K, Ansorge, O, Chromosome, 9 ALS/FTD Consortium, French research network on, Ftld/ftld/al, Italsgen, Consortium, Adamson, G, Bayer, Aj, Beck, J, Callister, Jb, Blake, Dj, Blumen, Sc, Collinge, J, Dunckley, T, Ealing, J, East, S, Elman, L, Gerhard, A, Guerreiro, Rj, Gwinn, K, Halliwell, N, Hamdalla, Hh, Hewitt, C, Ince, P, Jablonka, S, James, C, Kent, L, Knock, Jc, Lynch, T, Mahoney, C, Mann, D, Neal, J, Norris, D, O'Dowd, S, Richardson, A, Rossor, M, Rothstein, J, Scholz, Sw, Snowden, J, Stephan, Da, Toulson, G, Turner, Mr, Warren, Jd, Young, K, Weng, Yh, Kuo, Hc, Lai, Sc, Huang, Cl, Camuzat, A, Entraingues, L, Guillot, Noël, Verpillat, P, Blanc, F, Camu, W, Clerget Darpoux, F, Corcia, P, Couratier, P, Didic, M, Dubois, B, Duyckaerts, C, Guedj, E, Golfier, V, Habert, Mo, Hannequin, D, Lacomblez, L, Meininger, V, Salachas, F, Levy, R, Michel, Bf, Pasquier, F, Puel, M, Thomas Anterion, C, Sellal, F, Vercelletto, M, Moglia, C, Cammarosano, S, Canosa, A, Gallo, S, Brunetti, M, Ossola, I, Marinou, K, Papetti, L, Pisano, F, Pinter, Gl, Conte, A, Luigetti, M, Zollino, M, Lattante, S, Marangi, G, la Bella, V, Spataro, R, Colletti, T, Battistini, S, Ricci, C, Caponnetto, C, Mancardi, G, Mandich, P, Salvi, F, Bartolomei, I, Mandrioli, J, Sola, P, Lunetta, C, Penco, S, Monsurro', Maria Rosaria, Tedeschi, Gioacchino, Conforti, Fl, Gambardella, A, Quattrone, A, Volanti, P, Floris, G, Cannas, A, Piras, V, Marrosu, F, Marrosu, Mg, Murru, Mr, Pugliatti, M, Parish, Ld, Sotgiu, A, Solinas, G, Ulgheri, L, Ticca, A, Simone, I, Logroscino, G, Hernandez, Dg, Arepalli, S, Sabatelli, M, Mora, G, Corbo, M, Giannini, F, Calvo, A, Englund, E, Borghero, G, Floris, Gl, Remes, Am, Laaksovirta, H, Mccluskey, L, Trojanowski, Jq, Van Deerlin, Vm, Schellenberg, Gd, Nalls, Ma, Drory, Ve, Lu, C, Yeh, Th, Ishiura, H, Takahashi, Y, Tsuji, S, Le Ber, I, Brice, A, Drepper, C, Williams, N, Kirby, J, Shaw, P, Hardy, J, Tienari, Pj, Heutink, P, Morris, Hr, Pickering Brown, S, and Traynor, Bj

Published
2012

7. Positron emission tomography in patients with psychogenic non-epileptic seizures

Author

McGonigal A, Arthuis M, Micoulaud-Franchi JA, Bartolomei F, and Guedj E

Subjects
PET, PNES, brain metabolism, conversion disorder, psychogenic non-epileptic seizures, Neurosciences. Biological psychiatry. Neuropsychiatry, Neurology. Diseases of the nervous system, RC346-429, resting state, RC321-571
Abstract

Aileen McGonigal,1–3 Marie Arthuis,3 Jean-Arthur Micoulaud-Franchi,4,5 Fabrice Bartolomei,1–3 Eric Guedj6–8 1Institut de Neurosciences des Systèmes, INSERM UMR 1106, Marseille, France; 2Aix Marseille University, Faculty of Medicine, Marseille, France; 3Clinical Neurophysiology Department, Timone Hospital, Marseille, France; 4Department of Functional Investigation of the Nervous System, Sleep Clinic, Bordeaux University Hospital, Bordeaux, France; 5USR CNRS 3413, University of Bordeaux, France; 6Biophysics and Nuclear Medicine Department, Timone Hospital, Marseille, France; 7Aix-Marseille University, CERIMED, Marseille, France; 8Aix-Marseille University, CNRS, UMR7289, INT, Marseille, FranceWe have read with interest the recent review entitled “Uncovering the etiology of conversion disorder: insights from functional neuroimaging” by Maryam Ejareh dar and Richard AA Kanaan,1 published in Neuropsychiatric Disease and Treatment. Our paper on resting state brain metabolism measured by positron emission tomography (PET) was included and discussed.2 We were most surprised to see that the authors of the review seem to have misunderstood the findings of our study, which concerned patients with psychogenic non-epileptic seizures (PNES). The authors state that the 16 patients included in our study “were later found to have PNES with comorbid epilepsy”. This is incorrect, since our study included only patients with PNES in whom comorbid epilepsy was excluded. This crucial point is indeed detailed in the Methods section of our article and clearly stated in the abstract: “in all patients, the diagnosis was subsequently confirmed to be PNES with no coexisting epilepsy.” It is thus on the basis of incorrect understanding of our results that Drs Ejareh dar and Kanaan discuss the possible significance of hypometabolism in the anterior cingulate region described in our paper, and erroneously suggest that interpretation of PET findings is complicated by coexistent epilepsy, which was not in fact the case.Read the original article.&nbsp

Published
2016

8. A standardized [18F]-FDG-PET template for spatial normalization in statistical parametric mapping of dementia

Author

Della Rosa, Pa, Cerami, C, Gallivanone, F, Prestia, A, Caroli, A, Castiglioni, I, Gilardi, Mc, Frisoni, G, Friston, K, Ashburner, J, Perani, D, Drzezga, A, Perneczky, R, Didic, M, Guedj, E, Van Berckel, Bn, Ossenkoppele, R, Nobili, FLAVIO MARIANO, Morbelli, Silvia, Caroli, A., Della Rosa Pasquale, Anthony, Cerami, Chiara, Gallivanone, Francesca, Prestia, Annapaola, Caroli, Anna, Castiglioni, Isabella, Gilardi Maria, Carla, Frisoni, Giovanni, Friston, Karl, Ashburner, John, Perani, DANIELA FELICITA L., Della Rosa, P, Cerami, C, Gallivanone, F, Prestia, A, Caroli, A, Castiglioni, I, Gilardi, M, Frisoni, G, Friston, K, Ashburner, J, and Perani, D

Subjects
Male, Image Processing, computer.software_genre, ddc:616.89, Computer-Assisted, Brain/radionuclide imaging, Voxel, 80 and over, Image Processing, Computer-Assisted, Mild Cognitive Impairment/physiopathology/psychology/radionuclide imaging, Aged, 80 and over, Brain Mapping, medicine.diagnostic_test, Dementia/physiopathology/psychology/radionuclide imaging, General Neuroscience, Brain, Middle Aged, Positron emission tomography, Female, Psychology, 18F-FDG PET, Information Systems, Normalization (statistics), Image Processing, Computer-Assisted/methods, F-FDG PET, Statistical parametric mapping, Sensitivity and Specificity, Spatial normalization, Neuroimaging, Fluorodeoxyglucose F18, Brain Mapping/methods, medicine, 18F-FDG PET SPM (RRID:nif-0000-00343) Spatial normalization Template Dementia, Dementia, Humans, Cognitive Dysfunction, Aged, SPM (RRID:nif-0000-00343), Template, Case-Control Studies, Positron-Emission Tomography, Software, Neuroscience (all), business.industry, Dementia with Lewy bodies, medicine.disease, Positron-Emission Tomography/methods, Nuclear medicine, business, computer
Abstract

[18F]-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) is a widely used diagnostic tool that can detect and quantify pathophysiology, as assessed through changes in cerebral glucose metabolism. [18F]-FDG PET scans can be analyzed using voxel-based statistical methods such as Statistical Parametric Mapping (SPM) that provide statistical maps of brain abnormalities in single patients. In order to perform SPM, a “spatial normalization” of an individual’s PET scan is required to match a reference PET template. The PET template currently used for SPM normalization is based on [15O]-H2O images and does not resemble either the specific metabolic features of [18F]-FDG brain scans or the specific morphological characteristics of individual brains affected by neurodegeneration. Thus, our aim was to create a new [18F]-FDG PET aging and dementia-specific template for spatial normalization, based on images derived from both age-matched controls and patients. We hypothesized that this template would increase spatial normalization accuracy and thereby preserve crucial information for research and diagnostic purposes. We investigated the statistical sensitivity and registration accuracy of normalization procedures based on the standard and new template—at the single-subject and group level—independently for subjects with Mild Cognitive Impairment (MCI), probable Alzheimer’s Disease (AD), Frontotemporal lobar degeneration (FTLD) and dementia with Lewy bodies (DLB). We found a significant statistical effect of the population-specific FDG template-based normalisation in key anatomical regions for each dementia subtype, suggesting that spatial normalization with the new template provides more accurate estimates of metabolic abnormalities for single-subject and group analysis, and therefore, a more effective diagnostic measure.

Published
2014

11. EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography

Author

Aubry, N., Auffray, E., Mimoun, F. B., Brillouet, N., Bugalho, R., Charbon, E., Charles, O., Cortinovis, Daniele, Courday, P., Cserkaszky, A., Damon, C., Doroud, K., Fischer, J -M, Fornaro, G., Fourmigue, J -M, Frisch, B., Fürst, B., Gardiazabal, J., Garutti, E., Gadow, Karsten, Gaston, C., Gil-Ortiz, A., Guedj, E., Harion, T., Jarron, P., Kabadanian, J., Lasser, T., Laugier, R., Lecoq, P., Lombardo, D., Mandai, S., Mas, E., Meyer, T., Mundler, O., Navab, N., Ortigão, C., Paganoni, M., Perrodin, D., Pizzichemi, M., Prior, J. O., Reichl, T., Reinecke, M., Rolo, M., Schultz-Coulon, H -C, Schwaiger, M., Shen, W., Silenzi, A., Silva, J. C., Silva, R., Schweiger, I Somlai, Stamen, R., Traub, J., Varela, J., Veckalns, V., Vidal, V., Vishwas, J., Wendler, T., Xu, Chen, Ziegler, S., and Zvolsky, M.

Subjects
3. Good health
Abstract

14th INTERNATIONAL WORKSHOP ON RADIATION IMAGING DETECTORS, iworid 2012, FIGUEIRA DA FOZ, PORTUGAL, 1 Jul 2012 - 5 Jul 2012; Journal of Instrumentation 8(04), C04002 (2013). doi:10.1088/1748-0221/8/04/C04002, The EndoTOFPET-US project aims to develop a multimodal detector to foster the development of new biomarkers for prostate and pancreatic tumors. The detector will consist of two main components: an external plate, and a PET extension to an endoscopic ultrasound probe. The external plate is an array of LYSO crystals read out by silicon photomultipliers (SiPM) coupled to an Application Specific Integrated Circuit (ASIC). The internal probe will be an highly integrated and miniaturized detector made of LYSO crystals read out by a fully digital SiPM featuring photosensor elements and digital readout in the same chip. The position and orientation of the two detectors will be tracked with respect to the patient to allow the fusion of the metabolic image from the PET and the anatomic image from the ultrasound probe in the time frame of the medical procedure. The fused information can guide further interventions of the organ, such as biopsy or in vivo confocal microscopy., Published by Inst. of Physics, London

13. Results of sutures of the internal meniscus associated with reconstruction of the anterior cruciate ligament in chronic knee joint instability. Apropos of 42 cases, 30 of them controlled by arthrography,Résultats des sutures du ménisque interne associées à des reconstructions du ligament croisé antérieur dans les instabilités chroniques du genou. A propos de 42 cas, dont 30 contrôlés par arthrographie

Author

Lerat, J. L., Imbert, P., Moyen, B., jean-luc Besse, Brunet-Guedj, E., and Bochu, M.

14. 10 to 16 years follow-up results of 138 anterior cruciate ligament reconstruction for chronic instability of the knee using the central third of the patellar tendon augmented by extra-articular plasty,Les resultats apres 10 a 16 ans du traitement de la laxite chronique anterieure du genou par une reconstruction du ligament croise anterieur avec une greffe de tendon rotulien associee a une plastie extra-articulaire externe. A propos de 138 cas

Author

Lerat, J. L., Chotel, F., jean-luc Besse, Moyen, B., Binet, G., Craviari, T., Brunet-Guedj, E., Adeleine, P., and Nemoz, J. C.

19. Impact of florbetaben PET imaging on diagnosis and management of patients with suspected Alzheimer's Disease eligible for CSF analysis in France

Author

Ceccaldi, M., Jonveaux, T., Verger, A., Salmon, P. K., Houzard, C., Godefroy, O., Shields, T., Perrotin, A., Gismondi, R., Bullich, S., Jovalekic, A., Raffa, N., Florence Pasquier, Semah, F., Dubois, B., Habert, M. O., Hannequin, D., Chastan, M., Stephens, A., Guedj, E., Service de neurologie et de neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Médecine Nucléaire [CHRU Nancy], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Institute of Neuroscience and Medicine [Jülich] (INM-1), Hôpital des Charpennes [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), Service de Médecine Nucléaire [Amiens], CHU Amiens-Picardie, Piramal Imaging, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Roger Salengro [Lille], Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Service de médecine nucléaire [Marseille], DESSAIVRE, Louise, Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), Denver, CO, JUN 10-14, 2017; International audience

22. Spondylodiscitis complicating infective endocarditis

Author

Mesut Gun, Didier Raoult, Quentin Delpierre, Fanny Peugnet, Serge Cammilleri, Jean-Paul Casalta, Michel Drancourt, Antonello D'Andrea, Basile Mouhat, Francesco Santelli, Christophe Tribouilloy, Florent Arregle, Laurence Camoin-Jau, Hélène Martel, Yohann Bohbot, Alberto Riberi, Audrey Lieu, Laetitia Tessonnier, Andreina Carbone, Frédérique Gouriet, M. Philip, Frederic Collart, Gilbert Habib, Eric Guedj, Carbone, A., Lieu, A., Mouhat, B., Santelli, F., Philip, M., Bohbot, Y., Tessonnier, L., Peugnet, F., D'Andrea, A., Cammilleri, S., Delpierre, Q., Gouriet, F., Camoin-Jau, L., Gun, M., Casalta, J. -P., Riberi, A., Collart, F., Martel, H., Arregle, F., Guedj, E., Raoult, D., Drancourt, M., Tribouilloy, C., Habib, G., Hôpital de la Timone [CHU - APHM] (TIMONE), Université de Picardie Jules Verne (UPJV), Département de Médecine Nucléaire [AP-HM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)- Hôpital Nord [CHU - APHM], Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Assistance Publique - Hôpitaux de Marseille (APHM), Service Central de Biophysique et de Médecine Nucléaire, Service de Cardiologie [Amiens], CHU Amiens-Picardie, Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), and Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie

Subjects
Spondylodiscitis, Male, medicine.medical_specialty, Prognostic variable, Discitis, cardiac imaging and diagnostics, 030204 cardiovascular system & hematology, Multimodal Imaging, endocarditis, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, Positron Emission Tomography Computed Tomography, medicine, Endocarditis, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, In patient, Prospective Studies, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, cardiac imaging and diagnostic, business.industry, Mean age, Middle Aged, medicine.disease, Prognosis, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Infective endocarditis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Pyogenic spondylodiscitis, Female, Cardiology and Cardiovascular Medicine, Complication, business, 030217 neurology & neurosurgery
Abstract

ObjectiveThe primary objective was to assess the characteristics and prognosis of pyogenic spondylodiscitis (PS) in patients with infective endocarditis (IE). The secondary objectives were to assess the factors associated with occurrence of PS.MethodsProspective case–control bi-centre study of 1755 patients with definite IE with (n=150) or without (n=1605) PS. Clinical, microbiological and prognostic variables were recorded.ResultsPatients with PS were older (mean age 69.7±18 vs 66.2±14; p=0.004) and had more arterial hypertension (48% vs 34.5%; pStreptococcus gallolyticus were more frequent (24% vs 12% and 24% vs 11%; p18F-FDG PET/CT in 56 patients. In-hospital (16% vs 13.5%, p=0.38) and 1-year (21% vs 22%, p=0.82) mortalities did not differ between patients with or without PS.ConclusionsPS is a frequent complication of IE (8.5% of IE), is observed in older hypertensive patients with enterococcal or S. gallolyticus IE, and has a similar prognosis than other forms of IE. Since PS is associated with specific management, multimodality imaging including MRI, CT and PET/CT should be used for early diagnosis of this complication of endocarditis.

Published
2019

23. EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography

Author

Didier Perrodin, Shingo Mandai, Hans-Christian Schultz-Coulon, Tobias Lasser, T. Harion, Tobias Reichl, M Reinecke, O. Mundler, M. Rolo, Rainer Stamen, Joerg Traub, Benjamin Frisch, J M Fischer, M. Pizzichemi, O Charles, V Vidal, John O. Prior, C Damon, Wei Shen, Edoardo Charbon, B Fürst, F B Mimoun, Nassir Navab, Pierre Jarron, D. Cortinovis, João Carlos Silva, P Courday, Etiennette Auffray, Alessandro Silenzi, R Laugier, Giulia Alice Fornaro, I Somlai Schweiger, J Kabadanian, E Mas, José Gardiazabal, A Gil-Ortiz, N. Brillouet, T. C. Meyer, Catarina Ortigao, D Lombardo, C Gaston, Sibylle Ziegler, Thomas Wendler, C Xu, Markus Schwaiger, Viesturs Veckalns, R. Bugalho, J Vishwas, Nicolas Aubry, K Gadow, E Guedj, Paul Lecoq, Joao Varela, Erika Garutti, M. Zvolsky, Aron Cserkaszky, Rui F. Silva, K. Doroud, J.-M. Fourmigue, Marco Paganoni, Aubry, N, Auffray, E, Mimoun, F, Brillouet, N, Bugalho, R, Charbon, E, Charles, O, Cortinovis, D, Courday, P, Cserkaszky, A, Damon, C, Doroud, K, M. Fischer, J, Fornaro, G, M. Fourmigue, J, Frisch, B, Fürst, B, Gardiazabal, J, Gadow, K, Garutti, E, Gaston, C, Gil Ortiz, A, Guedj, E, Harion, T, Jarron, P, Kabadanian, J, Lasser, T, Laugier, R, Lecoq, P, Lombardo, D, Mandai, S, Mas, E, Meyer, T, Mundler, O, Navab, N, Ortigão, C, Paganoni, M, Perrodin, D, Pizzichemi, M, Prior, J, Reichl, T, Reinecke, M, Rolo, M, C. Schultz Coulon, H, Schwaiger, M, Shen, W, Silenzi, A, Silva, J, Silva, R, Somlai Schweiger, I, Stamen, R, Traub, J, Varela, J, Veckalns, V, Vidal, V, Vishwas, J, Wendler, T, Xu, C, Ziegler, S, and Zvolsky, M

Subjects
Intra-operative probe, medicine.medical_specialty, Computer science, Photodetector, 01 natural sciences, Lyso, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Silicon photomultiplier, Optics, Application-specific integrated circuit, law, 0103 physical sciences, medicine, Medical physics, Multimodality system, ddc:610, Instrumentation, Mathematical Physics, Gamma camera, medicine.diagnostic_test, 010308 nuclear & particles physics, business.industry, Orientation (computer vision), Detector, 3. Good health, Positron emission tomography, Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA), business
Abstract

The EndoTOFPET-US project aims to develop a multimodal detector to foster the development of new biomarkers for prostate and pancreatic tumors. The detector will consist of two main components: an external plate, and a PET extension to an endoscopic ultrasound probe. The external plate is an array of LYSO crystals read out by silicon photomultipliers (SiPM) coupled to an Application Specific Integrated Circuit (ASIC). The internal probe will be an highly integrated and miniaturized detector made of LYSO crystals read out by a fully digital SiPM featuring photosensor elements and digital readout in the same chip. The position and orientation of the two detectors will be tracked with respect to the patient to allow the fusion of the metabolic image from the PET and the anatomic image from the ultrasound probe in the time frame of the medical procedure. The fused information can guide further interventions of the organ, such as biopsy or in vivo confocal microscopy. © 2013 IOP Publishing Ltd and Sissa Medialab srl.

Published
2013

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