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The article is devoted to the study of various aspects of the activities and influence of Soviet musicians on the musical culture and education of Shanghai. The author comes to the conclusion that Russian musicians played an important role in the formation of the musical life of Shanghai and in general of the whole of China. Russian and European cultural and performing traditions were promoted by them, works of Russian and European authors were distributed, and their students were introduced to the masterpieces of world musical art. The traditions laid down by Russian musical figures at the beginning of the twentieth century were continued and strengthened by Soviet specialists who brought up a whole galaxy of outstanding musicians in China. The strengthening of Russian-Chinese relations after 1949 played a special role. Many Soviet musicians were sent to China by agreement of the countries. Among them were outstanding teachers and musicians: D. M. Serov, K.N. Dmitrevskaya, S. G. Delitsiev, N. N. Delitsieva, F. G. Arzamanov, I. G. Beridze, etc. They helped to develop curricula and programs, gave lectures, reports, held consultations and conducted teaching and organizational activities. The novelty of the article lies in the fact that for the first time it provides information about the work of the listed Soviet musicians and analyzes their influence on education at the Shanghai Conservatory.

Additional file 1: Figure S1. The workflow of KuA in treatment of OP. Figure S2. GO enrichment analysis among target genes. (A) Cell type signature. (B) Disgenet analysis. (C) Trrust analysis. (D) Pagenbase analysis. (E) Transcription factor. Figure S3. KuA improve the mechanical properties and inflammation level in OVX mice. (A) Stiffness of tibia. (B) Displacement of tibia. (C) Energy absorption. (D) serum IL-6. (E)serum CRP. (F) serum TNF-α. (G) serum IL-1b. (H) Principal genetic analysis among all variable. Figure S4. The PYGM related signaling pathway of potential target genes of LC in OP. Figure S5. KuA increased significantly the tibia and spine bone microstructure and mechanical properties in OVX mice. Figure S6. KuA increased significantly the spine bone microstructure and mechanical properties in OVX mice. Table S1. Primer Sequences used for RT-QPCR.

BackgroundsDiabetic retinopathy (DR) is one of the most severe microvascular complications of diabetes mellitus (DM). Secreted protein acidic and rich in cysteine (SPARC) has been found to play an important role in many diseases, but its role and mechanism in DR remain unknown.MethodsWe studied the role of SPARC and integrin β1 in vascular pathophysiology and identified potential therapeutic translation. The SPARC levels were tested in human serum and vitreous by ELISA assay, and then the Gene Expression Omnibus (GEO) dataset was used to understand the key role of the target gene in DR. In human retinal capillary endothelial cells (HRCECs), we analyzed the mRNA and protein level by RT-PCR, immunohistochemistry, and Western blotting. The cell apoptosis, cell viability, and angiogenesis were analyzed by flow cytometry, CCK-8, and tube formation.ResultsIn this study, we investigated the role of SPARC in the development and progression of human DR and high glucose-induced HRCEC cells and found that the SPARC-ITGB1 signaling pathway mimics early molecular and advanced neurovascular pathophysiology complications of DR. The result revealed that DR patients have a high-level SPARC expression in serum and vitreous. Knockdown of SPARC could decrease the expressions of inflammatory factors and VEGFR, inhibit cell apoptosis and angiogenesis, and increase cell viability by regulating integrin β1 in HRCECs.ConclusionSPARC promotes diabetic retinopathy via the regulation of integrin β1. The results of this study can provide a potential therapeutic application for the treatment of DR.