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12 results on '"Gris, J.-C."'

1. Catastrophic antiphospholipid syndrome and thromboses

Author

Makatsariya A.D. Makatsariya, Serov V.N. Serov, Gris J.-C. Gris, Grigoryeva K.N. Grigoryeva, Khizroeva D.Kh. Khizroeva, Mingalimov M.A. Mingalimov, Vorobyev A.V. Vorobyev, Shkoda A.S. Shkoda, and Bitsadze V.O. Bitsadze

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, General Medicine, Catastrophic antiphospholipid syndrome, business
Published
2019
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2. Antiphospholipid syndrome and pregnancy

Author

Bitsadze V.O. Bitsadze, Khamani N.M. Khamani, Makatsariya A.D. Makatsariya, Khizroeva D.Kh. Khizroeva, and Gris J.-C. Gris

Subjects
Pregnancy, medicine.medical_specialty, business.industry, Antiphospholipid syndrome, Obstetrics, medicine, General Medicine, medicine.disease, business
Published
2018
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3. Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients

Author

Cervera, R. Serrano, R. Pons-Estel, G. J. Ceberio-Hualde, L. and Shoenfeld, Y. de Ramon, E. Buonaiuto, V. Jacobsen, S. and Zeher, M. M. Tarr, T. Tincani, A. Taglietti, M. and Theodossiades, G. Nomikou, E. Galeazzi, M. Bellisai, F. and Meroni, P. L. Derksen, R. H. W. M. de Groot, P. G. D. and Baleva, M. Mosca, M. Bombardieri, S. Houssiau, F. Gris, J-C Quere, I. Hachulla, E. Vasconcelos, C. and Fernandez-Nebro, A. Haro, M. Amoura, Z. Miyara, M. and Tektonidou, M. Espinosa, G. Bertolaccini, M. L. Khamashta, M. A. Euro-Phospholipid Project Grp

Abstract

Objectives To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare the frequency of early manifestations with those that appeared later. Methods In 1999, we started an observational study of 1000 APS patients from 13 European countries. All had medical histories documented when entered into the study and were followed prospectively during the ensuing 10years. Results 53.1% of the patients had primary APS, 36.2% had APS associated with systemic lupus erythematosus and 10.7% APS associated with other diseases. Thrombotic events appeared in 166 (16.6%) patients during the first 5-year period and in 115 (14.4%) during the second 5-year period. The most common events were strokes, transient ischaemic attacks, deep vein thromboses and pulmonary embolism. 127 (15.5%) women became pregnant (188 pregnancies) and 72.9% of pregnancies succeeded in having one or more live births. The most common obstetric complication was early pregnancy loss (16.5% of the pregnancies). Intrauterine growth restriction (26.3% of the total live births) and prematurity (48.2%) were the most frequent fetal morbidities. 93 (9.3%) patients died and the most frequent causes of death were severe thrombosis (36.5%) and infections (26.9%). Nine (0.9%) cases of catastrophic APS occurred and 5 (55.6%) of them died. The survival probability at 10years was 90.7%. Conclusions Patients with APS still develop significant morbidity and mortality despite current treatment. It is imperative to increase the efforts in determining optimal prognostic markers and therapeutic measures to prevent these complications.

Published
2015

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