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A més, formà generacions de jurisconsults determinants en el dret català. Com a moralista aprofundeix la confessió i la penitència, i representa, també, la voluntat missionera del seu segle. Alguns elements clau mostren aquesta voluntat en la predicació: l’encàrrec de la Summa contra gentiles a Tomàs d’Aquino i la fundació de l’Ordre de la Mercè, juntament amb Pere Nolasc, i de les escoles de llengües orientals per als predicadors. Tanmateix, els autors de l’article defensen que l’únic model interpretatiu que engloba la seva complexa activitat és el que l’interpreta com a pensador cristià, en totes les seves facetes. No oblidem que la figura de Sant Ramon ha tingut, també, un model interpretatiu lligat a la santedat popular., Revista Catalana de Teologia, Vol. 47, Núm. 2 (2022)

Introduction Breast and prostate cancer survivors can experience impaired quality of life (QoL) in several QoL domains. The current strategy to support cancer survivors with impaired QoL is suboptimal, leading to unmet patient needs. ASCAPE aims to provide personalized- and artificial intelligence (AI)-based predictions for QoL issues in breast- and prostate cancer patients as well as to suggest potential interventions to their physicians to offer a more modern and holistic approach on cancer rehabilitation. Methods and analyses An AI-based platform aiming to predict QoL issues and suggest appropriate interventions to clinicians will be built based on patient data gathered through medical records, questionnaires, apps, and wearables. This platform will be prospectively evaluated through a longitudinal study where breast and prostate cancer survivors from four different study sites across the Europe will be enrolled. The evaluation of the AI-based follow-up strategy through the ASCAPE platform will be based on patients’ experience, engagement, and potential improvement in QoL during the study as well as on clinicians’ view on how ASCAPE platform impacts their clinical practice and doctor-patient relationship, and their experience in using the platform. Ethics and dissemination ASCAPE is the first research project that will prospectively investigate an AI-based approach for an individualized follow-up strategy for patients with breast- or prostate cancer focusing on patients’ QoL issues. ASCAPE represents a paradigm shift both in terms of a more individualized approach for follow-up based on QoL issues, which is an unmet need for cancer survivors, and in terms of how to use Big Data in cancer care through democratizing the knowledge and the access to AI and Big Data related innovations. Trial registration Trial Registration on clinicaltrials.gov: NCT04879563. © 2022 Tzelves et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Objective: To measure sexually active life expectancy (SALE) estimating the average age at which sexually active life nishes, paying special attention to the older population. Variations in SALE according to self-rated health are examined. Method: Descriptive analysis with cross-sectional data. SALE was calculated for the population by age group (30 to 80 years old) and sex using the Sullivan Method, with data from the Human Mortality Database and the National Survey of Sexual Health (Spain). The analysis distinguishes between individuals that have had coital sex in the last year and those who have not. Results: Coital activity continues in those aged from 55-59 years old, the SALE is 13.3 years in males and 8 in females. Coital activity is related to health and sexual health, diverging depending on sex and age group. The males showed a more extended sexually active trajectory than the females, but were also more inuenced by good general health (adding 2.6 and 1 years respectively) and good sexual health (5.2 and 4.3 years). SALE also varies when poor health (subtracting 2.7 years and adding 2 years) and poor sexual health (subtracting 2.9 and 1.3 years) are considered. Conclusions: the results reveal that sexual health programmes must be extended to the older ages, given that it is conrmed that sexual activity continues in old age.

As the European Parliament (EP) has progressively gained powers in the last decades, the life of the institution has been marked by growing complexity and the quest for increased legitimacy. The ma...

Durante los primeros días del confinamiento domiciliario, las universidades no disponían aún de las herramientas necesarias para implementar el nuevo modelo de clases online. Este artículo relata una experiencia de adaptación a contrarreloj, para continuar con las tareas lectivas de la asignatura 'Taller de Creación II' del Grado de Bellas Artes (UB): se propuso a los alumnos/as una serie de ejercicios prácticos utilizando recursos cotidianos como solución de emergencia para crear obras de arte.

Index de les obres ressenyades: Francisco TIRADO Miquel DOMÉNECH, Lo Social y lo Virtual

Prólogo de Juan Claudio de Ramón. El reconocimiento de naciones minoritarias ha sido una de las grandes cuestiones que ha preocupado a los teóricos políticos estos últimos años. Este ensayo explora los distintos esquemas de reconocimiento con la idea de llegar a una mejor construcción teórica que permita valorar el reconocimiento desde una perspectiva más justa. El autor distingue dos esferas para abordar el reconocimiento de las naciones minoritarias: el auto-gobierno y la construcción nacional. En esta investigación, el autor muestra la importancia de considerar estas dos esferas conjuntamente, como dos caras de la misma moneda, como un elemento crucial para este reconocimiento justo. Para ello, utiliza los casos de Canadá, Reino Unido, España y Suiza para desarrollar su teoría. The recognition of minority nations has been one question that has concerned many political theorists in recent years. This research explores the different schemas of recognition with the idea of finding a better construction that enables us to rethink recognition from a fairer perspective. The author distinguishes two important spheres to address the recognition of minority nations: the self-government sphere and the nation-building sphere. In this research, we show that these two spheres are two sides of the same coin and that it is crucial to think of them together to provide fair recognition of minority nations. The author uses the case of Canada, United Kingdom, Spain and Switzerland to develop his theory.

Nowadays, mobile communication networks are an essential part of our lives. They are present in both our personal and professional lives. The current networks are not prepared to support the population's future needs, such as having a reliable connection anytime and anywhere. The project shows an empirical design accompanied by a simulation and emulation platform for 3D networks based on UAVs and nanosatellites using functional virtualization of split B. In this regard, a completely virtualized test system has been created to attain the main objective of this study, i.e. to verify the results of previous theoretical studies on the virtualization of this split. Through a sample of the orbital arcs and the use of the experimental evaluation platform designed here, it has been possible to promisingly estimate the virtualization behaviour of this functional split. This study provides a new experimental tool in research on functional splits and verifies the operation of a split B in a virtualized 3D network scenario. Hoy en día, las redes de comunicación móvil son una parte esencial de nuestras vidas. Están presentes tanto en nuestra vida personal como profesional. Las redes actuales no están preparadas para soportar las necesidades futuras de la población, como tener una conexión confiable en cualquier momento y lugar. El proyecto muestra un diseño empírico acompañado de una plataforma de simulación y emulación para redes 3D basada en UAVs y nanosatélites utilizando virtualización funcional de split B. En este sentido, se ha creado un sistema de prueba completamente virtualizado para lograr el objetivo principal de este estudio, es decir verificar los resultados de estudios teóricos previos sobre la virtualización de esta escisión. A través de una muestra de los arcos orbitales y el uso de la plataforma de evaluación experimental diseñada aquí, ha sido posible estimar de manera prometedora el comportamiento de virtualización de esta división funcional. Este estudio proporciona una nueva herramienta experimental en la investigación de splits funcionales y verifica el funcionamiento de un split B en un escenario de red 3D virtualizada. Actualment, les xarxes de comunicacions mòbils són una part essencial de la nostra vida. Estan presents tant en la nostra vida personal com professional. Les xarxes actuals no estan preparades per donar suport a les necessitats futures de la població, com ara tenir una connexió fiable en qualsevol moment i en qualsevol lloc. El projecte mostra un disseny empíric acompanyat d’una plataforma de simulació i emulació per a xarxes 3D basades en UAV i nanosatèl·lits que utilitzen la virtualització funcional del split B. En aquest sentit, s’ha creat un sistema de proves completament virtualitzat per assolir l’objectiu principal d’aquest estudi, és a dir, per verificar els resultats d’estudis teòrics previs sobre la virtualització d’aquest split. Mitjançant una mostra dels arcs orbitals i l’ús de la plataforma d’avaluació experimental dissenyada aquí, s’ha pogut estimar prometedorament el comportament de virtualització d’aquest split funcional. Aquest estudi proporciona una nova eina experimental en la investigació dels splits funcionals i verifica el funcionament d’un split B en un escenari de xarxa 3D virtualitzada.

Index de les obres ressenyades: Francisco TIRADO Miquel DOMÉNECH, Lo Social y lo Virtual

El present treball, com a projecte final de carrera, té com objectiu estudiar la viabilitat del suro com a material alternatiu a compostos sintètics, com per exemple bescanviadors iònics convencionals. Està centrat al cas particular de la recuperació de Pal·ladi i Platí, metalls nobles d'alt valor econòmic i per tant amb un alt interès per la seva recuperació un cop usats.

OBJECTIVES: The effect of the use of immunomodulatory drugs on the risk of developing hospital-acquired bloodstream infection (BSI) in patients with COVID-19 has not been specifically assessed. We aim to identify risk factors for, and outcomes of, BSI among hospitalized patients with severe COVID-19 pneumonia. METHODS: We performed a severity matched case-control study (1:1 ratio) nested in a large multicentre prospective cohort of hospitalized adults with COVID-19. Cases with BSI were identified from the cohort database. Controls were matched for age, sex and acute respiratory distress syndrome. A Cox proportional hazard ratio model was performed. RESULTS: Of 2005 patients, 100 (4.98%) presented 142 episodes of BSI, mainly caused by coagulase-negative staphylococci, Enterococcus faecalis and Pseudomonas aeruginosa. Polymicrobial infection accounted for 23 episodes. The median time from admission to the first episode of BSI was 15 days (IQR 9-20), and the most frequent source was catheter-related infection. The characteristics of patients with and without BSI were similar, including the use of tocilizumab, corticosteroids, and combinations. In the multivariate analysis, the use of these immunomodulatory drugs was not associated with an increased risk of BSI. A Cox proportional hazard ratio (HR) model showed that after adjusting for the time factor, BSI was associated with a higher in-hospital mortality risk (HR 2.59; 1.65-4.07; p < 0.001). DISCUSSION: Hospital-acquired BSI in patients with severe COVID-19 pneumonia was uncommon and the use of immunomodulatory drugs was not associated with its development. When adjusting for the time factor, BSI was associated with a higher mortality risk.

Muro Solans, Joan García del (2017) Soldats del no-res València: Tres i Quatre, 194 p. Premi Octubre d’Assaig «Joan Fuster» 2016 ISBN 978-84-16789-72-6

RESUMEN: El transfeminismo se puede entender como un movimiento articulado a través de nuevas concepciones de la identidad, discursos activistas y prácticas políticas que interpelan el denominado feminismo institucional. Mi objetivo en este artículo es profundizar en el transfeminsimo como activismo que reconfigura el cuerpo como arma política y se esfuerza por proponer lecturas re-politizadas del placer y el deseo. Para ello me sirvo del diálogo entre la bibliografía científica y los textos producidos en contextos activistas. Una estrategia que me ayuda a perfilar los contornos de una estrategia de disidencia que se asienta, según discutiré en este texto, en la reformulación del sujeto político que experimenta placer; la resignificación de la colectividad como catalizador de la creatividad y, por último, la utilización de prácticas artísticas como vehículos de creación/difusión de las propuestas activistas. ABSTRACT: Transfeminism could be understood as a movement articulated through new identity conceptions, activist discourses, and political positions that question the denominated institutional feminism. In this paper, I intend to take a closer look to transfeminism as an activism that reshapes the body as a political instrument and emphasizes re-politicized readings, of pleasure and desire. For it, I make utilize the dialog between scientific literature and the writings produced in an activism context. As I further assert in this text, this strategy allows me to delineate the contours of a dissent strategy that lay down in the reformulation of the political subject that feels pleasure; the collectivity resignification as a creativity catalyzing agent and, finally, the use of artistic practices as vehicles for the creation/ dissemination of the political proposal.

espanolEl transfeminismo se puede entender como un movimiento articulado a traves de nuevas concepciones de la identidad, discursos activistas y practicas politicas que interpelan el denominado feminismo institucional. Mi objetivo en este articulo es profundizar en el transfeminsimo como activismo que reconfgura el cuerpo como arma politica y se esfuerza por proponer lecturas re-politizadas del placer y el deseo. Para ello me sirvo del dialogo entre la bibliografia cientifca y los textos producidos en contextos activistas. Una estrategia que me ayuda a perflar los contornos de una estrategia de disidencia que se asienta, segun discutire en este texto, en la reformulacion del sujeto politico que experimenta placer; la resignifcacion de la colectividad como catalizador de la creatividad y, por ultimo, la utilizacion de practicas artisticas como vehiculos de creacion/difusion de las propuestas activistas. EnglishTransfeminism could be understood as a movement articulated through new identity conceptions, activist discourses, and political positions that question the denominated institutional feminism. In this paper, I intend to take a closer look to transfeminism as an activism that reshapes the body as a political instrument and emphasizes re-politicized readings, of pleasure and desire. For it, I make utilize the dialog between scientifc literature and the writings produced in an activism context. As I further assert in this text, this strategy allows me to delineate the contours of a dissent strategy that lay down in the reformulation of the political subject that feels pleasure; the collectivity resignifcation as a creativity catalyzing agent and, fnally, the use of artistic practices as vehicles for the creation/ dissemination of the political proposal.

Historical references used by political representatives throughout time might reveal changes in the way policies are justified to society. For Spain, promoting Euro-Mediterranean relations within the framework of the Barcelona Process meant circumventing a certain traditional vision that saw Mediterranean policy as a legacy. Allusions to the past were often avoided, with preference to looking towards the future as a stimulus for regional cooperation. Nevertheless, Spanish foreign policy converged with the French and Italian outlook in grounding the European Union Mediterranean agenda on a shared historical discourse. However, the development of such discourse would not match the ultimate goal of enhancing regional cohesion, weakened the Barcelona Process itself, and undermined the European Union’s legitimacy as international actor in the Mediterranean.

In his time, Antonio de Capmany (1742-1813) was the most prominent intellectual in the service of the interests of Barcelona, in a willingness to articulate the energy of that city with the efforts of enlightened despotism to relaunch Spain as a continental and colonial power. Extensive knowledge and assimilation of European culture of the Enlightenment allowed him to associate the historical experience of the Catalan capital with modern values. It was not a simple varnish, since the defense of Barcelona as the focus of progress was constructed from documented empirical data and sensory impressions, according to the principles preached by the great British philosophers against speculative rationalism and its incessant occurrences.

Aquest article examina el paper de la violència en les relacions que estableixen déus i humans dins la tradició grecoromana. D’entre les diverses formes que aquesta violència pren en els mites, es tractarà la bèl·lica, la punitiva i la sexual. Aquestes apareixen envoltades de fenòmens com l’orgull humà, l’enveja divina i la metamorfosi física. A més, la violència és també present en pràctiques religioses fonamentals com el sacrifici i entronca amb la problemàtica del destí. Aquesta concepció de la divinitat, però, troba els seus primers crítics dins la mateixa Antiguitat., Este artículo examina el papel de la violencia en las relaciones que establecen dioses y humanos dentro de la tradición grecorromana. Entre las diferentes formas que esta violencia toma en los mitos, se tratará la bélica, la punitiva y la sexual. Estas aparecen rodeadas por fenómenos como el orgullo humano, la envidia divina y la metamorfosis física. Además, la violencia también está presente en prácticas religiosas fundamentales como el sacrificio y entronca con la problemática del destino. Esta concepción de la divinidad, aún así, encuentra a sus primeros críticos en la misma Antigüedad.

GEMICOMED (SEIMC) and the Spanish CANDI-Bundle Group., [Background] Candidaemia is a leading cause of bloodstream infections in hospitalized patients all over the world. It remains associated with high mortality., [Objectives] To assess the impact of implementing an evidence-based package of measures (bundle) on the quality of care and outcomes of candidaemia., [Methods] A systematic review of the literature was performed to identify measures related to better outcomes in candidaemia. Eight quality-of-care indicators (QCIs) were identified and a set of written recommendations (early treatment, echinocandins in septic shock, source control, follow-up blood culture, ophthalmoscopy, echocardiography, de-escalation, length of treatment) was prospectively implemented. The study was performed in 11 tertiary hospitals in Spain. A quasi-experimental design before and during bundle implementation (September 2016 to February 2018) was used. For the pre-intervention period, data from the prospective national surveillance were used (May 2010 to April 2011)., [Results] A total of 385 and 263 episodes were included in the pre-intervention and intervention groups, respectively. Adherence to all QCIs improved in the intervention group. The intervention group had a decrease in early (OR 0.46; 95% CI 0.23–0.89; P = 0.022) and overall (OR 0.61; 95% CI 0.4–0.94; P = 0.023) mortality after controlling for potential confounders., [Conclusions] Implementing a structured, evidence-based intervention bundle significantly improved patient care and early and overall mortality in patients with candidaemia. Institutions should embrace this objective strategy and use the bundle as a means to measure high-quality medical care of patients., This study was funded by a research grant from the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (FIS PI15/00744). This study is also co-financed by the European Development Regional Fund ‘A way to achieve Europe’ ERDF, Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008). The funding institutions had no role in the design or performance of the research. C.G.-V. is a recipient of an INTENSIFICACIÓ Grant from the ‘Strategic plan for research and innovation in health-PERIS 2016–2020’ and forms part of the FungiCLINIC Research group (AGAUR-Project 2017SGR1432 of the Catalan Health Agency).

Women's health concerns are generally underrepresented in basic and translational research, but reproductive health in particular has been hampered by a lack of understanding of basic uterine and menstrual physiology. Menstrual health is an integral part of overall health because between menarche and menopause, most women menstruate. Yet for tens of millions of women around the world, menstruation regularly and often catastrophically disrupts their physical, mental, and social well-being. Enhancing our understanding of the underlying phenomena involved in menstruation, abnormal uterine bleeding, and other menstruation-related disorders will move us closer to the goal of personalized care. Furthermore, a deeper mechanistic understanding of menstruation-a fast, scarless healing process in healthy individuals-will likely yield insights into a myriad of other diseases involving regulation of vascular function locally and systemically. We also recognize that many women now delay pregnancy and that there is an increasing desire for fertility and uterine preservation. In September 2018, the Gynecologic Health and Disease Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development convened a 2-day meeting, "Menstruation: Science and Society" with an aim to "identify gaps and opportunities in menstruation science and to raise awareness of the need for more research in this field." Experts in fields ranging from the evolutionary role of menstruation to basic endometrial biology (including omic analysis of the endometrium, stem cells and tissue engineering of the endometrium, endometrial microbiome, and abnormal uterine bleeding and fibroids) and translational medicine (imaging and sampling modalities, patient-focused analysis of menstrual disorders including abnormal uterine bleeding, smart technologies or applications and mobile health platforms) to societal challenges in health literacy and dissemination frameworks across different economic and cultural landscapes shared current state-of-the-art and future vision, incorporating the patient voice at the launch of the meeting. Here, we provide an enhanced meeting report with extensive up-to-date (as of submission) context, capturing the spectrum from how the basic processes of menstruation commence in response to progesterone withdrawal, through the role of tissue-resident and circulating stem and progenitor cells in monthly regeneration-and current gaps in knowledge on how dysregulation leads to abnormal uterine bleeding and other menstruation-related disorders such as adenomyosis, endometriosis, and fibroids-to the clinical challenges in diagnostics, treatment, and patient and societal education. We conclude with an overview of how the global agenda concerning menstruation, and specifically menstrual health and hygiene, are gaining momentum, ranging from increasing investment in addressing menstruation-related barriers facing girls in schools in low- to middle-income countries to the more recent "menstrual equity" and "period poverty" movements spreading across high-income countries.

Investigation of the microbial community in the female reproductive tract with the use of sequencing techniques has revealed that endometrial samples obtained through a transvaginal catheter are dominated by Lactobacillus species. Dysbiotic changes in the endometrial microbiota may be associated with implantation failure or early spontaneous abortion in patients who undergo assisted reproductive technology treatment. Whether or not there is an endometrial microbiota in early pregnancy is unknown. Herein we describe, the human endometrial microbiota in a patient who subsequently had an 8th week spontaneous clinical miscarriage with euploid embryos in the next cycle and, for the first time, during a successful pregnancy in which the endometrial fluid was sampled at 4 weeks of gestation. The microbial profile found on the endometrial sample before the spontaneous abortion had higher bacterial diversity and lower Lactobacillus abundance than the endometrial fluid from the healthy pregnancy. Functional metagenomics detected different Lactobacillus species between the 2 samples. Lactobacillus crispatus was present in the endometrium before the spontaneous abortion, as were other bacteria involved in dysbiosis, which had an unstable functional pattern characterized by transposases and insertion elements. Lactobacillus iners was the most prevalent microbe found in the endometrium during early pregnancy; its presence was associated with defense mechanisms and basal functions. These novel observations prompt future investigations to understand the potential implications of microbiology on healthy and pathologic human pregnancy.

Las elecciones municipales del 2015 supusieron, en el contexto del País Valencià, un impulso a la política de participación. Tras las elecciones, estas intenciones se materializaron en la consideración institucional de órganos como las concejalías de participación, áreas o servicios. Es desde esta toma de conciencia que la Cátedra Gobierno Abierto, Participación Ciudadana y Open Data promovida por la Conselleria de Transparencia, Responsabilidad Social, Participación y Cooperación de la Generalitat Valenciana y la Universitat de València, se plantea llevar a cabo una investigación cualitativa que nos ofrezca información sobre los procesos de inclusión e impulso de la participación ciudadana en las políticas sociales del ámbito local. En este artículo presentamos los resultados del ejercicio analítico que hemos llevado a cabo en el marco de esta investigación cualitativa: comparar los discursos sobre el impulso de las políticas de participación en el ámbito local provenientes de los agentes institucionales (lo que hemos llamado la participación institucional), con los preceptos básicos del método IAP. La investigación que presentamos aquí tuvo, desde su origen, la mirada puesta en la Comunidad Autónoma como unidad de análisis. Se han realizado 15 entrevistas semi-estructuradas a responsables locales de las áreas de participación ciudadana en los ayuntamientos de las provincias de Castellón, Alicante y Valencia. El análisis del material cualitativo apunta a algunas barreras y confusiones, tanto en lo referente al propio concepto de participación como a la falta de anclaje con los preceptos de la IAP en tanto que método que afloran como limitaciones para la implantación de políticas de participación a nivel local. La conclusión que se puede extraer apunta a la necesidad de articulación de un modelo de participación para el País Valencià.The municipal elections of 2015 gave a boost, in País Valencià, to the participation policy. In the agendas of the parties of the entire ideological spectrum, the need to activate citizen participation and transparency was mentioned. After the elections, these intentions materialized in the institutional consideration of bodies such as the councils of participation, areas or services. It is from this realization that the Cátedra Gobierno Abierto, Participación Ciudadana y Open Data promoted by the Conselleria de Transparencia, Responsabilidad Social, Participación y Cooperación de la Generalitat Valenciana and the Universitat de València aims to carry out qualitative research that provides us with information on the processes of inclusion and boosting citizen participation in social policies at the local administration level. In this paper we present the results of the analytical exercise that we have carried out within the framework of this qualitative research: to compare the discourses on the impulse of participation policies at the local level coming from institutional agents (what we have called institutional participation), with the basic precepts of the PRA as a method. The research presented here has, since its inception, looked at the Autonomous Community as a unit of analysis. Fifteen semi-structured interviews have been conducted with local political actors from the areas of citizen participation in Castellón, Alicante and Valencia City Councils. The analysis of qualitative material points to some barriers and confusions, both regarding the concept of participation itself and the lack of consideration of PRA as a process, which emerge as limitations for the implementation of participation policies at the local level. The conclusion that can be drawn points to the need to articulate a model of participation for the País Valencià.

L’arxiver i historiador Josep Maria Grau i Pujol ens fa un breu resum, proporcionant-nos algunes de les dades i estadístiques més rellevants, del seu nou llibre: Migracions d’entrada i sortida a Riudoms (1910-1950), que ha estat recentment editat pel Centre d’Estudis Riudomencs Arnau de Palomar. A més, aquest llibre va guanyar el Premi Arnau de Palomar, el 2015, en la categoria d’investigació i és el núm. 32 dels Quaderns de Divulgació Cultural, de la col·lecció editorial del CERAP.

Objectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people >= 65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. Results: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age >= 85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and >= 1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). Conclusions: The incidence of IPD in people >= 65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, >= 1 high-risk condition, and PCV13 serotypes. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

OBJECTIVES: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people =65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. METHODS: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. RESULTS: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age =85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and =1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). CONCLUSIONS: The incidence of IPD in people =65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, =1 high-risk condition, and PCV13 serotypes.

Background Despite being considered a high-risk population for invasive fungal disease, specific features of candidemia among solid organ transplant (SOT) recipients remain poorly characterized. Methods We compiled prospective data from two multicenter studies on candidemia performed over two consecutive periods in Spain: the CANDIPOP Study (2010-2011) and the CANDI-Bundle Study (2016-2018). Episodes diagnosed in adult SOT recipients in 10 participating centers were included. Risk factors for clinical failure (all-cause 7-day mortality and/or persistent candidemia for >= 72 hours) and 30-day mortality were investigated by univariate analysis. Results We included 55 episodes of post-transplant candidemia (32 and 23 of which occurred during the first and second periods). Kidney (38.2%) and liver recipients (30.9%) were the most common populations. Candida albicans accounted for 27.3% of episodes. The proportion of C glabrata increased over time (18.8% vs 30.4% for the first and second periods). There were no differences in the rate of fluconazole non-susceptible isolates (50.0% vs 60.0%, respectively). Clinical failure and 30-day mortality occurred in 25.5% and 27.3% of episodes and were associated with the severity of candidemia (Pitt score and severe sepsis/septic shock). Kidney transplantation (unadjusted odds ratio [uOR]: 0.17; 95% confidence interval [CI]: 0.03-0.85; P-value = .020), early catheter removal (uOR: 0.15; 95% CI: 0.03-0.76; P-value = .013), and appropriate early antifungal therapy (uOR: 0.14; 95% CI: 0.02-0.89; P-value = .041) were protective for 30-day mortality. Conclusions High rates of non-albicans species and fluconazole non-susceptibility must be taken into account to optimize therapeutic management and outcomes in SOT recipients with candidemia.

CANDIPOP Project, the CANDI‐Bundle Group GEIRAS‐GEMICOMED (SEIMC) REIPI., [Background] Despite being considered a high‐risk population for invasive fungal disease, specific features of candidemia among solid organ transplant (SOT) recipients remain poorly characterized., [Methods] We compiled prospective data from two multicenter studies on candidemia performed over two consecutive periods in Spain: the CANDIPOP Study (2010‐2011) and the CANDI‐Bundle Study (2016‐2018). Episodes diagnosed in adult SOT recipients in 10 participating centers were included. Risk factors for clinical failure (all‐cause 7‐day mortality and/or persistent candidemia for ≥72 hours) and 30‐day mortality were investigated by univariate analysis., [Results] We included 55 episodes of post‐transplant candidemia (32 and 23 of which occurred during the first and second periods). Kidney (38.2%) and liver recipients (30.9%) were the most common populations. Candida albicans accounted for 27.3% of episodes. The proportion of C glabrata increased over time (18.8% vs 30.4% for the first and second periods). There were no differences in the rate of fluconazole non‐susceptible isolates (50.0% vs 60.0%, respectively). Clinical failure and 30‐day mortality occurred in 25.5% and 27.3% of episodes and were associated with the severity of candidemia (Pitt score and severe sepsis/septic shock). Kidney transplantation (unadjusted odds ratio [uOR]: 0.17; 95% confidence interval [CI]: 0.03‐0.85; P ‐value = .020), early catheter removal (uOR: 0.15; 95% CI: 0.03‐0.76; P ‐value = .013), and appropriate early antifungal therapy (uOR: 0.14; 95% CI: 0.02‐0.89; P ‐value = .041) were protective for 30‐day mortality., [Conclusions] High rates of non‐albicans species and fluconazole non‐susceptibility must be taken into account to optimize therapeutic management and outcomes in SOT recipients with candidemia., The CANDIPOP Project was supported by non‐restrictive research grants from Gilead Sciences, MSD, Astellas Pharma, and Pfizer. This study was cofounded by Fundación SEIMC‐GESIDA, by the Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III (co‐financed by the European Development Regional Fund [ERDF] >A way to achieve Europe>), and by the Spanish Network for Research in Infectious Diseases (REIPI RD12/0015). The CANDI‐Bundle Study was supported by “Plan Nacional de I + D+I” and Instituto de Salud Carlos III (Fondo de Investigaciones Sanitarias [FIS] PI15/00744), Subdirección General de Redes y Centros de Investigación Cooperativa, Spanish Ministry of Science, Innovation and Universities, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016). MFR holds a research contract “Miguel Servet” (CP 18/00073) from the Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III.

17 cuentos infantiles, ilustraciones y guías didácticas para trabajar a partir de la Convención de las Naciones Unidas sobre los Derechos de los Niños y las Niñas, Los cuentos de este compendio y las guías didácticas que los acompañan harán referencia a los artículos del documento Convención de las Naciones Unidas sobre los Derechos de los Niños y las Niñas, promovido y elaborado por el Fondo de las Naciones Unidas para la Infancia (UNICEF). Dicho documento está a disposición pública, a través de la página web de la organización, en el siguiente enlace: https://www.unicef.es/sites/unicef.es/files/comunicacion/ConvencionsobrelosDerechosdelNino.pdf

Compartir ideas. La universidad va al instituto es un proyecto de aprendizaje servicio transversal de la Universidad de Barcelona. Este representa una propuesta de aprendizaje servicio que bajo una estructura común permite la participación de estudiantes y profesorado de distintas disciplinas en un mismo proyecto. El aprendizaje servicio (ApS) es una propuesta formativa que permite el desarrollo de diferentes tipos de aprendizajes a partir de la implicación en necesidades sociales reales con la intención de transformarlas (Tapia, 2001; Martínez, 2008; Puig, 2009). En este tipo de proyectos están presentes simultáneamente la intencionalidad pedagógica y la intencionalidad solidaria. Se pueden definir como experiencias educativas solidarias protagonizadas por estudiantes, que tienen como objetivo atender a una necesidad de los destinatarios a la vez que planificar y mejorar la calidad de los aprendizajes (Tapia, 2006).