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1. 'Greener' Synthesis of Zoledronic Acid from Imidazol-1-yl-acetic Acid and P-Reagents Using Diethyl Carbonate as the Solvent Component

Author

Grün Alajos, Keglevich György, and Szalai Zsuzsanna

Subjects
Solvent, Acetic acid, chemistry.chemical_compound, Zoledronic acid, chemistry, Component (thermodynamics), Reagent, Organic Chemistry, medicine, Diethyl carbonate, Biochemistry, medicine.drug, Nuclear chemistry
Abstract

The synthesis of a third generation dronic acid, zoledronic acid by the reaction of imidazol- 1-yl-acetic acid with phosphorus trichloride/phosphorous acid in diethyl carbonate (DEC) as a “green” solvent, and in DEC – methanesulfonic acid (MSA) solvent mixtures is described. The earlier not “green” and expensive MSA and sulfolane solvents may be replaced by DEC.

Published
2021
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