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1. Aβ8-20 Fragment as an Anti-Fibrillogenic and Neuroprotective Agent: Advancing toward Efficient Alzheimer’s Disease Treatment

Author: Stefania Zimbone, Maria Laura Giuffrida, Giuseppina Sabatino, Giuseppe Di Natale, Rita Tosto, Grazia M. L. Consoli, Danilo Milardi, Giuseppe Pappalardo, and Michele F.M. Sciacca
Subjects: Physiology, Cognitive Neuroscience, Cell Biology, General Medicine, Biochemistry
Published: 2023
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2. Quantifying the relationship between specialisation and reputation in an online platform

Author: Giacomo Livan, Giuseppe Pappalardo, Rosario N. Mantegna, Livan, Giacomo, Pappalardo, Giuseppe, and Mantegna, Rosario N
Subjects: Physics - Physics and Society, Multidisciplinary, H Social Sciences, FOS: Physical sciences, Physics and Society (physics.soc-ph), FEEDBACK, SYSTEMSCOOPERATION, ECONOMICS, EVOLUTION, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Abstract: Online platforms implement digital reputation systems in order to steer individual user behaviour towards outcomes that are deemed desirable on a collective level. At the same time, most online platforms are highly decentralised environments, leaving their users plenty of room to pursue different strategies and diversify behaviour. We provide a statistical characterisation of the user behaviour emerging from the interplay of such competing forces in Stack Overflow, a long-standing knowledge sharing platform. Over the 11 years covered by our analysis, we represent the interactions between users and topics as bipartite networks. We find such networks to display nested structures akin to those observed in ecological systems, demonstrating that the platform’s user base consistently self-organises into specialists and generalists, i.e., users who focus on narrow and broad sets of topics, respectively. We relate the emergence of these behaviours to the platform’s reputation system with a series of data-driven models, and find specialisation to be statistically associated with a higher ability to post the best answers to a question. We contrast our findings with observations made in top-down environments—such as firms and corporations—where generalist skills are consistently found to be more successful.
Published: 2022

3. Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease?

Author: Giuseppe Di Natale, Giuseppina Sabatino, Michele Francesco Maria Sciacca, Rita Tosto, Danilo Milardi, and Giuseppe Pappalardo
Subjects: Ions, Amyloid, Amyloid beta-Peptides, Organic Chemistry, Pharmaceutical Science, Amyloidogenic Proteins, tau Proteins, Amyloidosis, Lipids, Analytical Chemistry, Chemistry (miscellaneous), Alzheimer Disease, Metals, Drug Discovery, Molecular Medicine, Humans, Physical and Theoretical Chemistry
Abstract: In the last two decades, the amyloid hypothesis, i.e., the abnormal accumulation of toxic Aβ assemblies in the brain, has been considered the mainstream concept sustaining research in Alzheimer’s Disease (AD). However, the course of cognitive decline and AD development better correlates with tau accumulation rather than amyloid peptide deposition. Moreover, all clinical trials of amyloid-targeting drug candidates have been unsuccessful, implicitly suggesting that the amyloid hypothesis needs significant amendments. Accumulating evidence supports the existence of a series of potentially dangerous relationships between Aβ oligomeric species and tau protein in AD. However, the molecular determinants underlying pathogenic Aβ/tau cross interactions are not fully understood. Here, we discuss the common features of Aβ and tau molecules, with special emphasis on: (i) the critical role played by metal dyshomeostasis in promoting both Aβ and tau aggregation and oxidative stress, in AD; (ii) the effects of lipid membranes on Aβ and tau (co)-aggregation at the membrane interface; (iii) the potential of small peptide-based inhibitors of Aβ and tau misfolding as therapeutic tools in AD. Although the molecular mechanism underlying the direct Aβ/tau interaction remains largely unknown, the arguments discussed in this review may help reinforcing the current view of a synergistic Aβ/tau molecular crosstalk in AD and stimulate further research to mechanism elucidation and next-generation AD therapeutics.
Published: 2022

4. Riflessioni sull'attuale percorso di transizione in Italia

Author: Laura Giovanna Giannoni, Massimo Di Grazia, Giuseppe Pappalardo, Luca Semenzato, Maria Laura Mitra, and Clara Baldin
Subjects: 03 medical and health sciences, 030505 public health, 050903 gender studies, 05 social sciences, General Medicine, 0509 other social sciences, 0305 other medical science
Abstract: In questo articolo gli autori esamineranno l'attuale situazione italiana per quanto concerne i trattamenti di conferma del genere (GCT) e, alla luce delle ulti-me ricerche e review della letteratura sui GCT, verranno analizzate e confrontate le linee guida dell'Osservatorio Nazionale sull'Identità di Genere (ONIG) e della World Professional Association for Transgender Health (WPATH). Gli autori mostreranno come l'attuale percorso, che prevede, prima dell'accesso ai GCT, la risoluzione di ogni altro disagio psichico presente, potrebbe essere modificato per mi-gliorare lo stato di benessere delle persone transgender e gender non-conforming (TGNC), trattando la disforia prima o contemporaneamente ai disturbi secondari. Si evidenzierà inoltre come la popolazione affetta da disforia di genere risulti par-ticolarmente suscettibile allo sviluppo di disturbi psichiatrici, con evidenti costi in termini di qualità di vita per la persona e per il sistema sanitario che deve farsene carico. Infine, verrà evidenziato che il miglioramento dei servizi sociosanitari per le persone transgender contribuirebbe a migliorare la qualità della vita della popola-zione TGNC italiana anche grazie ad una depatologizzazione delle identità non coerenti col genere assegnato.
Published: 2020
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5. A Decentralized Solution for Epidemiological Surveillance in Campus Scenarios

Author: Andrea Fornaia, Giovanni Marotta, Giuseppe Pappalardo, and Emiliano Tramontana
Subjects: distributed systems, General Computer Science, data analysis, General Engineering, smart contracts, contact tracing, localization, mobile applications, Blockchain, Blockchain, contact tracing, data analysis, decentralized apps, distributed systems, epi- demiological surveillance, localization, mobile applications, smart contracts, General Materials Science, Electrical and Electronic Engineering, decentralized apps, epi- demiological surveillance
Published: 2022

6. Providing Trust in a Dynamic Distributed Energy Production Scenario by means of a Blockchain

Author: Andrea Calvagna, Ernesto Casablanca, Giovanni Marotta, Giuseppe Pappalardo, and Emiliano Tramontana
Subjects: blockchain, distributed energy production
Published: 2022

7. A (Reverse) Mutation Testing Approach to Automatically generate parallel C/C++ Code

Author: Salvatore Calanna, Andrea Calvagna, Salvatore Campisi, Andrea Fornaia, Giuseppe Pappalardo, Riccardo Torrisi, and Emiliano Tramontana
Published: 2021
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8. Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer’s disease on Aβ1-40 peptide early assembly

Author: Serena Lazzaro, Lieke Lamont, Nina Ogrinc, Giuseppe Pappalardo, Ron M. A. Heeren, Graziella Vecchio, National Research Council [Catania], The Maastricht Multimodal Molecular Imaging Institute, University of Catania [Italy], and SALZET, Michel
Subjects: Spectrometry, Mass, Electrospray Ionization, Multivariate statistics, Ion-mobility spectrometry, [SDV]Life Sciences [q-bio], Alzheimer’s disease (AD), Peptide, 02 engineering and technology, Mass spectrometry, Multivariate statistical analysis (MVA), 01 natural sciences, Biochemistry, Amyloid β-peptide oligomers, Electrospray ionization-ion mobility-mass spectrometry (ESI-IM-MS), Analytical Chemistry, Alzheimer Disease, Tandem Mass Spectrometry, Ion Mobility Spectrometry, Humans, chemistry.chemical_classification, Amyloid beta-Peptides, Drug discovery, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, Peptide Fragments, In vitro, 3. Good health, 0104 chemical sciences, [SDV] Life Sciences [q-bio], Drug development, chemistry, Multivariate Analysis, 0210 nano-technology, Alzheimer's disease (AD) . Amyloid ?-peptide oligomers . Electrospray ionization-ion mobility-mass spectrometry (ESI-IM-MS) . Multivariate statistical analysis (MVA), Research Paper, Conjugate
Abstract: Inhibition of the initial stages of amyloid-β peptide self-assembly is a key approach in drug development for Alzheimer’s disease, in which soluble and highly neurotoxic low molecular weight oligomers are produced and aggregate in the brain over time. Here we report a high-throughput method based on ion mobility mass spectrometry and multivariate statistical analysis to rapidly select statistically significant early-stage species of amyloid-β1-40 whose formation is inhibited by a candidate theranostic agent. Using this method, we have confirmed the inhibition of a Zn-porphyrin-peptide conjugate in the early self-assembly of Aβ40 peptide. The MS/MS fragmentation patterns of the species detected in the samples containing the Zn-porphyrin-peptide conjugate suggested a porphyrin-catalyzed oxidation at Met-35(O) of Aβ40. We introduce ion mobility MS combined with multivariate statistics as a systematic approach to perform data analytics in drug discovery/amyloid research that aims at the evaluation of the inhibitory effect on the Aβ early assembly in vitro models at very low concentration levels of Aβ peptides. Electronic supplementary material The online version of this article (10.1007/s00216-019-02030-7) contains supplementary material, which is available to authorized users.
Published: 2019
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9. KLVFF oligopeptide-decorated amphiphilic cyclodextrin nanomagnets for selective amyloid beta recognition and fishing

Author: Antonino Mazzaglia, Giuseppe Di Natale, Rita Tosto, Angela Scala, Giuseppe Sortino, Anna Piperno, Maria Pia Casaletto, Alberto Riminucci, Maria Laura Giuffrida, Placido G. Mineo, Valentina Villari, Norberto Micali, and Giuseppe Pappalardo
Subjects: MALDI-TOF analysis, Cyclodextrins, Amyloid beta-Peptides, Beta amyloid, Nanoassemblies, Peptide Fragments, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Biomaterials, Nanovesicles, Colloid and Surface Chemistry, Magnetic nanoparticles, Hunting, Amphiphilic cyclodextrins, Fishing, Molecular recognition, Oligopeptides, Hybrid aggregates
Abstract: Recognition and capture ofamyloidbeta (Aβ) is a challenging task for the early diagnosis of neurodegenerative disorders, such as Alzheimer’s disease. Here, we report a novel KLVFF-modified nanomagnet based on magneticnanoparticles(MNP) covered with a non-ionic amphiphilic β-cyclodextrin (SC16OH) and decorated with KLVFFoligopeptidefor the self-recognition of the homologous amino-acids sequence of Aβ to collect Aβ (1–42) peptide from aqueous samples. MNP@SC16OH and MNP@SC16OH/Ada-Pep nanoassemblies were fully characterized by complementary techniques both as solid powders and in aqueous dispersions. Single domain MNP@SC16OH/Ada-Pep nanomagnets of 20–40nm were observed by TEM analysis.DLSand ζ-potential measurements revealed that MNP@SC16OH nanoassemblies owned in aqueous dispersion ahydrodynamic radiusof about 150nm, which was unaffected by Ada-Pep decoration, while the negative ζ-potential of MNP@SC16OH (−40mV) became less negative (−30mV) in MNP@SC16OH/Ada-Pep, confirming the exposition of positively charged KLVFF on nanomagnets surface. The ability of MNP@SC16OH/Ada-Pep to recruit Aβ (1–42) in aqueous solution was evaluated by MALDI-TOF and compared with the ineffectiveness of undecorated MNP@SC16OH and VFLKF scrambled peptide-decorated nanoassemblies (MNP@SC16OH/Ada-scPep), pointing out theselectivityof KLVFF-decoratednanohybridtowards Aβ (1–42). Finally, the property of nanomagnets to extract Aβ inconditioned mediumof cells over-producing Aβ peptides was investigated as proof of concept of effectiveness of thesenanomaterialsas potential diagnostic tools.
Published: 2021

10. Understanding the interaction between amyloid-?-peptide (1-42) and its aggregation inhibitors: application of ESI and MALDI mass spectrometry

Author: Giuseppe Di Natale, Rita Tosto, Grazia Maria Letizia Consoli, and Giuseppe Pappalardo
Subjects: Amyloid, ESI, MALDI, peptide, mass spectrometry
Abstract: Neurodegenerative disorders (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases are some of the most common forms of age-related diseases. Even if pathogenesis of these neurodegenerative diseases remains unclear, increasing evidences point out a common critical molecular process involving the assembly of various aggregated protein with a ?-sheet conformation, termed amyloids. The inhibition of this process could be a viable therapeutic strategy for the treatment of neurodegenerative diseases. Peptide based inhibitors of ?-amyloid fibrillation are emerging as safe drug candidates as well as interesting compounds for early diagnosis of AD. Some papers in the past reported that the KLVFF peptide, by binding the homologous sequence in full- length A?, can prevent at aggregation into fibrils and this ability is maintained after conjugation to different scaffold. One of the main hindrances in amyloid protein investigation concerns the low peptide solubility. In this contest, the high sensitivity of mass spectrometry may overcome this limit. Besides measuring the m/z, mass spectrometry enables the identification of adducts formation and it can be used to obtain direct evidence of the interaction between A?(1-42) and its aggregation inhibitors. Despite these informations were deduced from the gas-phase system, the results observed support what can be observed in solution by limited proteolysis experiments. In particular, the identification of proteolysis resistant peptides fragments by mass spectrometry can reveal the binding regions of A?(1-42) to specific molecules in solution. Here we report two different mass spectrometry approaches to investigate the interaction of A?(1-42) monomer with aggregation inhibitors that we recently studied. In particular, high resolution mass spectrometry (HR-MS) was employed to point out direct interaction of the p-amino-calix[4]arene-GPGKLVFF conjugate with the A?(1-42) monomer.[5] We resorted to limited proteolysis experiments to investigate, by means of MALDI-TOF, the interaction of A?(1-42) with chimera peptides ?9-16-KL and ?26-33-KL and KLVFF.[6]
Published: 2021

11. NausiChain: A Mobile Decentralized App Ensuring Service Continuity to University Life in Covid-19 Emergency Times

Author: Agatino Moschitta, Emiliano Tramontana, Giovanni Marotta, Andrea Fornaia, and Giuseppe Pappalardo
Subjects: Immutability, Point (typography), Computer science, business.industry, IT service continuity, Internet privacy, Context (language use), Tracing, business, Transparency (behavior), Decentralization, Anonymity
Abstract: In an effort to contain the Covid-19 pandemic emergency, nations have sponsored smartphones apps tracing contacts. The ultimate aim is to alert people when a Covid-19-positive has been found and it occurs that they have been in close contact with the positive. In the context of contact tracing, transparency of data gathered is of utmost importance to show beyond doubt that the people privacy is preserved as much as possible. The proposed approach aims at making gathered data publicly available in such a way that anonymity is preserved and stored data are immutable and not owned by a single organization. For this, we equip users in a university environment with an app that reveals their presence as a proximity to a WiFi access point. While the server-side provides location ids to apps, the location history is kept within the app and checks for a possible contact are performed by the app. The server aggregates presence data related to each WiFi access point according to time-slots, and stores these periodically in a blockchain for maximum transparency and immutability. The tests on the developed prototype have shown the accuracy in determining presence data, the feasibility for apps to interact with smart contracts and to have daily presence data stored in a blockchain. The ability to exhibit official and immutable statistics on people gathering at university should be useful to give evidence of the effort to have controlled accesses and gathering avoidance.
Published: 2021

12. Tau/A? chimera peptides: A Thioflavin-T and MALDI-TOF study of A? amyloidosis in the presence of Cu(II) or Zn(II) ions and total lipid brain extract (TLBE) vesicles

Author: Danilo Milardi, Giuseppe Di Natale, Giuseppe Pappalardo, and Michele Sciacca
Subjects: Proteolysis, Metal ions in aqueous solution, Tau protein, Hyperphosphorylation, tau Proteins, Biochemistry, chemistry.chemical_compound, Protein Aggregates, Alzheimer Disease, Amyloids, medicine, Humans, Metal ions, Molecular Biology, Unilamellar Liposomes, Amyloid beta-Peptides, biology, medicine.diagnostic_test, Chemistry, Amyloidosis, Vesicle, Organic Chemistry, Cell Biology, medicine.disease, Peptide Fragments, Kinetics, Zinc, Membrane, Spectrometry, Fluorescence, membranes, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, Biophysics, Thioflavin, Peptides, Copper
Abstract: Currently, Alzheimer's Disease (AD) is a complex neurodegenerative condition, with limited therapeutic options. Several factors, like Amyloid β (Aβ) aggregation, tau protein hyperphosphorylation, bio-metals dyshomeostasis and oxidative stress contribute to AD pathogenesis. These pathogenic processes might occur in the aqueous phase but also on neuronal membranes. Thus, investigating the connection between Aβ and biomembranes, becomes important for unveiling the molecular mechanism underlying Aβ amyloidosis as a critical event in AD pathology. In this work, the interaction of two peptides, made up with hybrid sequences from Tau protein 9-16 (EVMEDHAG) or 26-33 (QGGYTMHQ) N-terminal domain and Aβ16-20 (KLVFF) hydrophobic region, with full length Aβ40 or Aβ42 peptides is reported. The studied "chimera" peptides Ac-EVMEDHAGKLVFF-NH2 (τ9-16-KL) and Ac-QGGYTMHQKLVFF-NH2 (τ26-33-KL) are endowed with Aβ recognition and metal ion interaction capabilities provided by the tau or Aβ sequences, respectively. These peptides were characterized in previous study along with their metal dependent interaction and amyloidogenesis, either in the presence or absence of metal ion and artificial membranes made up with Total Lipid Brain Extract (TLBE) components, (Sciacca et al., 2020). In the present paper, the ability of the two peptides to inhibit Aβ aggregation is studied using composite experimental conditions including aqueous solution, the presence of metal ions (Cu or Zn), the presence of lipid vesicles mimicking neuronal membranes as well as the co-presence of metals and TLBE artificial membranes. We used Thioflavine-T (ThT) fluorescence or MALDI-TOF spectrometry analysis of Aβ limited proteolysis to respectively monitor the Aβ aggregation kinetic or validation of the Aβ interacting regions. We demonstrate that τ9-16-KL and τ26-33-KL peptides differently affect Aβ aggregation kinetics, with the tau sequence playing a crucial role. The results are discussed in terms of chimera's peptides hydrophobicity and electrostatic driven interactions at the aqueous/membrane interface.
Published: 2021
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13. Copper (II) binding properties of an octapeptide fragment from the R3 region of tau protein: A combined potentiometric, spectroscopic and mass spectrometric study

Author: Giuseppe Di Natale, Giuseppe Pappalardo, Katalin Várnagy, Imre Sóvágó, Giovanni Tabbì, Bence Szakács, and Bettina Diána Balogh
Subjects: Stereochemistry, Potentiometric titration, chemistry.chemical_element, tau Proteins, 010402 general chemistry, 01 natural sciences, Biochemistry, Inorganic Chemistry, Residue (chemistry), chemistry.chemical_compound, Deprotonation, Protein Domains, Coordination Complexes, Amide, Imidazole, Histidine, Binding Sites, 2-histidine containing peptides, complexes, copper, ii, protein, r3 domain of tau, 010405 organic chemistry, Chemistry, Circular Dichroism, Electron Spin Resonance Spectroscopy, Electrochemical Techniques, Ligand (biochemistry), Copper, Peptide Fragments, 0104 chemical sciences, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Binding
Abstract: The copper(II) complexes of a peptide fragment of the R3 domain of tau protein (tau(326-333) Ac-GNIHHKPG-NH2) and its mutants (Ac-GNGHHKPG-NH2, Ac-GNIHHKAG-NH2, Ac-GNGAHKPG-NH2 and Ac-GNGHAKPG-NH2) have been studied by potentiometric and spectroscopic (UV-Vis, CD) methods. ESR spectroscopy and mass spectrometry were also used to prove the coordination mode of the mononuclear complexes and the formation of dinuclear species, respectively. It has been demonstrated that the (326-333) fragment of tau protein is a versatile and effective ligand for copper(II) coordination. The versatility of copper(II) binding is related to the presence of two adjacent histidyl residues in the sequence, which results in the coexistence of mononuclear, bis(ligand) and dinuclear complexes at different metal to ligand ratios. The 1:1 mononuclear complexes are, however, the dominant species with all peptides and the imidazole-N and one to three deprotonated amide nitrogen atoms towards the N-terminal side of the histidyl residue have been suggested as metal binding sites. This binding mode allows the formation of coordination isomers because any of the two histidine moieties can be the primary anchoring site. It is evident from the CD spectroscopic measurements that the isomers are present in almost equal concentration. The copper(II) binding affinity of the native fragment of tau protein is comparable to that of a similar 2-histidine fragment of amyloid-β mutant, Ac-SGAEGHHQK-NH2 but the comparison with an independent histidyl residue (H32) from the N-terminal region of the protein reveals the predominance of H32 over the histidines in the R3 domain.
Published: 2021
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14. Linguistic Factors Affecting Moraic Duration in Spontaneous Japanese

Author: Giuseppe Pappalardo
Subjects: Settore L-OR/22 - Lingue e Letterature del Giappone e della Corea, medicine.medical_specialty, Duration (music), Spoken corpora. Moraic isochrony. Durational compensation. Inherent segment duration. Vowel devoicing. Pitch accent, medicine, Audiology, Psychology
Abstract: Japanese is often referred to as a mora-timed language (Ladefoged 1975): the mora has been described as the psychological prosodic unit in the spoken language, and it is the metric unit of traditional poetry (Bloch 1950). However, it is clear that morae are not strictly isochronous units (Beckman 1982). Thus, experimental studies have focused on detecting compensation effects that make average mora durations more equal through the modulation of the inherent duration of the segments involved (Han 1962; Port, Al-Ani, Maeda 1980; Homma 1981; Hoequist 1983a; 1983b; Warner, Arai 2001). Kawahara (2017) used the Corpus of Spontaneous Japanese to verify whether the durational compensation effect within a /CV/ mora occurs in natural speech, in addition to read speech in the lab. He observed a statistically significant compensation effect of /CV/ morae, in which vowel duration tends to vary in response to the duration of the preceding consonant. However, as the same author has pointed out, the compensation is not absolute because there are several linguistic factors that potentially affect segments’ duration profiles. This study will support the idea that moraic isochrony does not occur in spontaneous Japanese by presenting empirical data on how linguistic factors can considerably affect variation in the average duration of morae.
Published: 2020
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15. Tau-peptide fragments and their copper(II) complexes: Effects on Amyloid-β aggregation

Author: Giuseppe Di Natale, Michele Sciacca, Tiziana Campagna, Giuseppe Pappalardo, and Francesco Bellia
Subjects: 0301 basic medicine, Amyloid beta, Electrospray ionization, Tau protein, chemistry.chemical_element, Peptide, Peptide aggregation, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Materials Chemistry, Physical and Theoretical Chemistry, chemistry.chemical_classification, biology, Chemistry, ESI-MS, Fibrillogenesis, Copper, In vitro, Peptide Conformation, 030104 developmental biology, Biochemistry, biology.protein, Amyloid-beta, 030217 neurology & neurosurgery
Abstract: Recent studies suggest that the interaction of Aβ and Tau may be significant in the pathogenesis of Alzheimer’s diseases (AD). In addition, the potential influence of copper on Tau-related pathology in AD has not been previously addresseded and the interaction between Tau protein, Aβ and copper has even more recently been associated with AD. While the copper(II) interaction with the Aβ peptide has exhaustively been studied, the few studies carried out on copper(II) complexes with peptide fragments from Tau protein have been focused on the pseudo-repeats of Tau protein in the microtubule-binding region. No data have been reported about the metal complexes with peptides derived from the N-terminal portion of Tau protein, outside the microtubule-binding domain, despite increased levels of peptide fragments from this region have been detected in the Cerebrospinal fluid (CSF) of AD patients. Here we examine the interaction of two peptides fragments, encompassing the 1–25 or 26–44 residues of the human Tau protein sequence, with Aβ as well as the Cu2+-binding features of these two naturally occurring peptides. The CD experiments showed that copper(II) differently affects the peptide conformation of the two ligands and provided also insight into the donor atoms involved in metal coordination. Stoichiometry of copper(II) complexes was obtained by means of High resolution ESI-MS. Finally, the influence of the studied peptide on Aβ’s fibrillogenesis, either in the presence or absence of Cu2+, was investigated by means of Th-T fluorescence coupled with turbidimetric measurements. The observed different effect on the in vitro Aβ’s aggregation, was correlated with the affinity of copper(II) with the two peptide ligands. The overall results indicate that copper(II) can bind these peptides using the histidine residue or amino group as anchoring sites and that copper(II) binding may have a possible involvement in AD.
Published: 2018
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16. Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases

Author: Giuseppe Di Natale, Danilo Milardi, Valeria Lanza, and Giuseppe Pappalardo
Subjects: Drug, media_common.quotation_subject, Disease, Pharmacology, metallostasis, 010402 general chemistry, Bioinformatics, 01 natural sciences, Biochemistry, Neuroprotection, Drug Discovery, Humans, Medicine, Repurposing, Chelating Agents, media_common, drug repurposing, 010405 organic chemistry, Drug discovery, business.industry, Clioquinol, Organic Chemistry, Neurodegeneration, Drug Repositioning, Neurodegenerative Diseases, medicine.disease, 0104 chemical sciences, Drug repositioning, Molecular Medicine, metformin, cyclodipeptides, business, Copper, Central Nervous System Agents, medicine.drug
Abstract: Background: There is mounting urgency to find new drugs for the treatment of neurodegenerative disorders. A large number of reviews have exhaustively described either the molecular or clinical aspects of neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD). Conversely, reports outlining how known drugs in use for other diseases can also be effective as therapeutic agents in neurodegenerative diseases are less reported. This review focuses on the current uses of some copper(II) chelating molecules as potential drug candidates in neurodegeneration. Methods: Starting from the well-known harmful relationships existing between the dyshomeostasis and mis-management of metals and AD onset, we surveyed the experimental work reported in the literature, which deals with the repositioning of metal-chelating drugs in the field of neurodegenerative diseases. The reviewed papers were retrieved from common literature and their selection was limited to those describing the biomolecular aspects associated with neuroprotection. In particular, we emphasized the copper(II) coordination abilities of the selected drugs. Results: Copper, together with zinc and iron, are known to play a key role in regulating neuronal functions. Changes in copper homeostasis are crucial for several neurodegenerative disorders. The studies included in this review may provide an overview on the current strategies aimed at repurposing copper (II) chelating drugs for the treatment of neurodegenerative disorders. Starting from the exemplary case of clioquinol repurposing, we discuss the challenge and the opportunities that repurposing of other metal-chelating drugs may provide (e.g. PBT-2, metformin and cyclodipeptides) in the treatment of neurodegenerative disease. Conclusions: In order to improve the success rate of drug repositioning, comprehensive studies on the molecular mechanism and therapeutic efficacy are still required. The present review upholds that drug repurposing makes significant advantages over drug discovery since repositioned drugs had already passed the safety and toxicity tests. Promising drug candidates in neurodegenerative diseases may be represented by copper chelating classes of drugs, provided that sufficient details on their mechanism of action are available to encourage further investigations and clinical trials.
Published: 2018
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17. Cyclodextrin Polymers as Delivery Systems for Targeted Anti-Cancer Chemotherapy

Author: Domenico Spinelli, Alessia Distefano, Maurizio Viale, Fabrizio Loiacono, Giuseppe Pappalardo, Noemi Bognanni, Nadia Bertola, Rita Tosto, Graziella Vecchio, and Marco Ponassi
Subjects: Arginine, Amino Acid Motifs, carbohydrates, Pharmaceutical Science, Antineoplastic Agents, Peptide, doxorubicin, Article, Analytical Chemistry, QD241-441, Drug Delivery Systems, Drug Discovery, polycyclic compounds, medicine, Humans, cancer, Doxorubicin, Physical and Theoretical Chemistry, Cellulose, Cell Proliferation, chemistry.chemical_classification, Drug Carriers, cyclodextrins, Cyclodextrin, Chemistry, beta-Cyclodextrins, oxaliplatin, Organic Chemistry, Hep G2 Cells, Combinatorial chemistry, Amino acid, A549 Cells, Chemistry (miscellaneous), Cell culture, doxorubricin, Drug delivery, Cancer cell, Molecular Medicine, nanoparticles, gamma-Cyclodextrins, medicine.drug
Abstract: In the few last years, nanosystems have emerged as a potential therapeutic approach to improve the efficacy and selectivity of many drugs. Cyclodextrins (CyDs) and their nanoparticles have been widely investigated as drug delivery systems. The covalent functionalization of CyD polymer nanoparticles with targeting molecules can improve the therapeutic potential of this family of nanosystems. In this study, we investigated cross-linked γ- and β-cyclodextrin polymers as carriers for doxorubicin (ox) and oxaliplatin (Oxa). We also functionalized γ-CyD polymer bearing COOH functionalities with arginine-glycine-aspartic or arginine moieties for targeting the integrin receptors of cancer cells. We tested the Dox and Oxa anti-proliferative activity in the presence of the precursor polymer with COOH functionalities and its derivatives in A549 (lung, carcinoma) and HepG2 (liver, carcinoma) cell lines. We found that CyD polymers can significantly improve the antiproliferative activity of Dox in HepG2 cell lines only, whereas the cytotoxic activity of Oxa resulted as enhanced in both cell lines. The peptide or amino acid functionalized CyD polymers, loaded with Dox, did not show any additional effect compared to the precursor polymer. Finally, studies of Dox uptake showed that the higher antiproliferative activity of complexes correlates with the higher accumulation of Dox inside the cells. The results show that CyD polymers could be used as carriers for repositioning classical anticancer drugs such as Dox or Oxa to increase their antitumor activity.
Published: 2021
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18. A Python framework for programming autonomous robots using a declarative approach

Author: Fabrizio Messina, Giuseppe Pappalardo, Corrado Santoro, and Loris Fichera
Subjects: business.industry, Programming language, Computer science, 020207 software engineering, 02 engineering and technology, Python (programming language), computer.software_genre, Metaprogramming, Operational semantics, Software, Software agent, Virtual machine, Component-based software engineering, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, business, computer, computer.programming_language, Software Design and Development
Abstract: This paper describes PROFETA (standing for Python RObotic Framework for dEsigning sTrAtegies), a framework for the programming of autonomous robots based on the Belief-Desire-Intention (BDI) software model. PROFETA is inspired by AgentSpeak(L), a formal language for the creation of BDI software agents. The framework is implemented in Python, and utilizes the metaprogramming capabilities offered by this language to implement the operational semantics of AgentSpeak(L). PROFETA provides a flexible environment offering both traditional object-oriented imperative constructs and declarative constructs , enabling the definition of a robot's high-level behavior in a simple, natural way. The contributions of this paper, in the area of software design and development, are: (i) a methodology, equipped with suitable technical solutions, to extend the Python programming language with AgentSpeak(L) declarative constructs; and (ii) a unified environment enabling software components for robots to be developed using a single language (Python) within a single runtime environment (the Python virtual machine). A comparison between PROFETA and other similar frameworks is provided, illustrating common aspects and key differences.
Published: 2017
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19. Web-based Simulations of Multi-agent Systems

Author: Fabrizio Messina, Giuseppe Pappalardo, Massimiliano De Benedetti, and Corrado Santoro
Subjects: 020203 distributed computing, Web-based simulation, Computer science, business.industry, Distributed computing, Multi-agent system, 02 engineering and technology, Network topology, JavaScript, Computer Graphics and Computer-Aided Design, Set (abstract data type), Modeling and Simulation, Models of communication, 0202 electrical engineering, electronic engineering, information engineering, Web application, 020201 artificial intelligence & image processing, Architecture, business, computer, Software, computer.programming_language
Abstract: This paper describes the architecture of AgentSimJs, a Javascript-based multi-agent simulator intended to execute and visualize simulations through a Web browser. It includes the needed capabilities to render a 3D scene with objects and agents. AgentSimJs has a modular architecture, the several different components provide a set of flexible primitives to program the agent behaviour. With AgentSimJs, a user can perform a fine tuning of all the aspects related to communication, motion, and group formation. Users can also define a custom network topology and communication model.
Published: 2017
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20. J/ψ suppression at forward rapidity in Pb–Pb collisions at sNN=5.02 TeV

Author: Alessandra Lattuca, Jochen Klein, Silvia Arcelli, Dariusz Czeslaw Miskowiec, Trine Spedstad Tveter, Ivan Kisel, Jinsook Kim, Nora De Marco, Gabriele Gaetano Fronze, Ionel Stan, Levente Molnar, Paolo Camerini, Sergey Voloshin, Meike Charlotte Danisch, Pasquale Di Nezza, Christophe Furget, Jean Willy Andre Cleymans, Volker Lindenstruth, Francesca Soramel, Dmitry Budnikov, Jaroslav Adam, Roy Crawford Lemmon, Yajun Mao, Igor Pshenichnov, Domenico Colella, Mona Sharma, Manuel Colocci, Martin Andreas Volkl, Evgeny Karpechev, Markus Keil, Andrea Festanti, Jun Takahashi, Jana Bielcikova, Marton Vargyas, Antonio Di Mauro, I. Das, Camilo Ernesto Lara Martinez, Peter Zahariev Hristov, Jan Figiel, Vladimir Samsonov, Alberto Caliva, Andre Mischke, Jovan Milosevic, Klaus Barth, Christine Nattrass, Sandun Pahula Hewage, P. Cerello, Bjarte Kileng, Rama Chandra Baral, Peter Graham Jones, Rafael Derradi De Souza, Tribeni Mishra, Pradip Kumar Sahu, Rosario Nania, Satyajit Jena, M. Estienne, Anders Garritt Knospe, Alberto Baldisseri, V. Lenti, Ulrich Fuchs, Corrado Gargiulo, Arianna Batista Camejo, Sandro Bjelogrlic, Manoj Bhanudas Jadhav, Ken Oyama, Ali Okatan, Christoph Mayer, Benjamin Andreas Hess, Smbat Grigoryan, Rainer Martin Schicker, Ernesto Calvo Villar, Andrzej Deloff, Wladyslaw Henryk Trzaska, Madalina-Gabriela Tarzila, Lizardo Valencia Palomo, Dezso Varga, Andrew John Lowe, Pedro Gonzalez Zamora, Alex Henri Jean Chauvin, D. De Gruttola, Panagiotis Christakoglou, Jonghan Park, Kyungeon Choi, Paolo Giubellino, Pierre Vande Vyvre, Philippe Crochet, Sona Pochybova, Anatoly Kolozhvari, Austin Vincent Harton, J. Book, Robert Helmut Munzer, Sang Un Ahn, Valentina Zaccolo, Youngil Kwon, Andrey Zarochentsev, Bogdan Theodor Rascanu, Andre Augustinus, Alexandre Alarcon Do Passo Suaide, Annalisa De Caro, Stefan Thomas Heckel, Wanchaloem Poonsawat, Ankita Sharma, Massimiliano Marchisone, Deepa Thomas, Andrey Reshetin, Hans Rudolf Schmidt, Sergey Filchagin, Marco Bregant, Marie Germain, Franco Meddi, Philipp Johannes Luettig, Mihai Petrovici, Ara Grigoryan, Anik Gupta, Pranjal Sarma, Somnath Kar, Ulrich Michael Frankenfeld, Sebastian Rosado Navarro, Maksym Zyzak, Erin Frances Gauger, Yuri Melikyan, Olja Dordic, Dmitry Aleksandrov, Sukalyan Chattopadhyay, Marcello Lunardon, Jogender Saini, Mais Kazim Oglu Suleymanov, Franck Manso, Chinorat Kobdaj, Piotr Jan Gasik, Vikas Singhal, Antonino Zichichi, M. Spyropoulou-Stassinaki, Marcelo Gameiro Munhoz, Ilya Selyuzhenkov, Benedetto Di Ruzza, Alice Elisabeth Ohlson, Zuman Zhang, Marcello Borri, Alexander Vodopyanov, Sudipan De, Ju Hwan Kang, Alexandr Tumkin, Bernd Stefan Windelband, Valeria Muccifora, Lucina Gabriela Espinoza Beltran, Florian Herrmann, Ritsuya Hosokawa, Tyler Harrison Lutz, Saehanseul Oh, Varlen Grabski, Emilia Leogrande, Alexander Szabo, Filip Krizek, Taesoo Kim, Premomoy Ghosh, Konstantin Mikhaylov, Viktor Ratza, Bernhard Skaali, Laurent Ducroux, Pragati Sahoo, Sk Noor Alam, Alexander Vinogradov, Eugen Mudnic, Astrid Vauthier, Amalia Pop, Rachid Guernane, Anisa Khatun, Iwona Anna Sputowska, Camila De Conti, Catherine Micaela Silvestre, Chitrasen Jena, Sun Kun Oh, Fedor Guber, Nur Hussain, Jorn Henning Putschke, Imrich Szarka, Dong Jo Kim, Nicole Bastid, Shyam Kumar, Hanna Paulina Zbroszczyk, Constantinos Loizides, Toru Sugitate, Michele Floris, Jongsik Eum, Oton Vazquez Doce, Vladimir Kaplin, Soren Pontoppidan Sorensen, Vytautas Vislavicius, Oksana Shadura, Marek Kowalski, Rosario Turrisi, Evgeny Kondratyuk, Branislav Sitar, Sanjib Muhuri, Zixuan Song, Friederike Bock, M. A. Lisa, Gyula Bencedi, Matej Oravec, Dmitry Yurevich Peresunko, Hermes Leon Vargas, Alexei Khanzadeev, Jamila Bashir Butt, Jesse Thomas Buxton, Rainer Arno Ernst Renfordt, Andrew Michael Kubera, Petr Nomokonov, Steffen Georg Weber, Jan Cabala, Hikari Murakami, Ankhi Roy, Fabian Ng, Barthelemy von Haller, Catia Petta, Sidharth Kumar Prasad, Katie Leanne Graham, Francesco Bossu, Chaosong Gao, Saikat Biswas, Jean-Luc Fernand Charvet, Latchezar Betev, Alexey Bogdanov, Arild Velure, Antonio Uras, Raphaelle Marie Bailhache, Stefania Beole, Zhuo Zhou, Maitreyee Mukherjee, Kjetil Ullaland, Jørgen André Lien, Jacobus Onderwaater, Luis Manuel Montano Zetina, Lucile Ronflette, Eulogio Serradilla Rodriguez, Greeshma Koyithatta Meethaleveedu, Rishat Sultanov, Hongbo Zhu, Sergey Kiselev, Elisa Incani, Chiara Oppedisano, Yury Kharlov, Junjie Zhu, Luciano Musa, Hector Bello Martinez, Michal Meres, Tiziano Virgili, Christian Claude Kuhn, Peter Braun-Munzinger, A. Nedosekin, Xinye Peng, Bedangadas Mohanty, Andrea Alici, Pietro Cortese, Bruno Espagnon, H. Bøggild, Ian Gardner Bearden, Mohamad Tarhini, Sebastian Lehner, Javier Ernesto Castillo Castellanos, Francesco Riggi, Ali Zaman, Christian Lippmann, Sebastian Klewin, Panagiota Foka, S. Schuchmann, Jerzy Gustaw Bartke, Fatiha Lehas, Peter Chochula, Alexander Kluge, David Horak, Rashmi Raniwala, Redmer Alexander Bertens, A. S. Gonzalez, Oliver Werner Arnold, Christophe Pierre Suire, Mesut Arslandok, Marco Marquard, Gerardo Antonio Herrera Corral, G. Volpe, Inayat Rasool Bhat, Alexey Kuryakin, Antoine Xavier Lardeux, Miguel Martinez Pedreira, Sanjeev Singh Sambyal, Luis Alberto Perez Moreno, Jacopo Margutti, Sergey Nikolaev, Ganesh Jagannath Tambave, Attiq Ur Rehman, Motoi Inaba, Elisa Meninno, Anastasia Maria Barbano, Thorsten Kollegger, Caio Lagana Fernandes, Shakeel Ahmad, Jin Hee Yoon, Richard Daniel Majka, Eugenio Scapparone, Henner Buesching, Erik Brücken, Vladimir Izucheev, Zubayer Ahammed, Giacomo Vito Margagliotti, Lukasz Kamil Graczykowski, Marc Weber, Andrew John Castro, Matteo Lupi, Nikolay Zavyalov, Caio Alves Garcia Prado, Ashik Ikbal Sheikh, Philippe Rosnet, Ralf Keidel, Alice Zimmermann, Lilit Karayan, David H. Evans, T. Breitner, Konstantin Munning, Antonio Carlos Oliveira da Silva, Jorge Mercado-perez, Kunal Garg, Vladimir Belyaev, D. H. Kim, Grigorii Feofilov, Andrey Vasiliev, Sibaji Raha, Filip Erhardt, Gabor Biro, Naghmeh Mohammadi, Vladislav Grigoryev, Giuseppe Bruno, Karel Safarik, Tomoya Tsuji, Dennis Franz Weiser, Peter Levai, Filimon Roukoutakis, Alis Rodriguez Manso, Audrey Francisco, Andry Malala Rakotozafindrabe, Tuva Ora Herenui Richert, Markus Bernhard Zimmermann, Krzysztof Redlich, Sami Sakari Rasanen, Enrico Scomparin, Arseniy Shabanov, Myunggeun Song, Lucia Leardini, Jurgen Schukraft, Yves Roland Schutz, Ashutosh Pandey, Jubin Mitra, Federica Sozzi, Johan Alme, Luciano Ramello, Liudmila Malinina, Cristian Andrei, Leticia Cunqueiro Mendez, Daicui Zhou, M. E. Connors, Aurora Diozcora Vargas Trevino, Michal Sefcik, Werner Riegler, Chengxin Zhao, Jennifer Lynn Klay, Evgeny Kryshen, Venelin Anguelov, Linda Vickovic, Eliane Epple, Joel Anthony Mazer, Francesca Bellini, Diego Stocco, Victor Trubnikov, Rama Narayana Singaraju, Oleg Karavichev, Mihaela Gheata, Gustavo Conesa Balbastre, Sagarika Swain, Stefan Kirsch, Sergey Nikulin, Mikhail Malaev, Gergely Gabor Barnafoldi, Giuseppe Pappalardo, Ermanno Vercellin, Artem Konevskikh, Tahir Hussain, Debojit Sarkar, Christian Holm Christensen, Cristiane Jahnke, Beomsu Chang, Tatiana Drozhzhova, Catalin-Lucian Ristea, Peter Kalinak, Valery Punin, D. Vranic, S.A. Zaporozhets, Vitaly Loginov, Marianna Mazzilli, Adriana Telesca, Caterina Deplano, Marian Krivda, Julien Faivre, Salvatore De Pasquale, Teodor Siemiarczuk, Zhang Chunhui, Yonghong Zhang, E. G. Ferreiro, Ketil Roeed, Yasser Corrales Morales, I. Erdemir, Adrian Sevcenco, Anatoly Tikhonov, Vladimir V. Isakov, Ramona Lea, Claude Andre Pruneau, Roberto Barbera, Elena Botta, Zhongbao Yin, Alexander Nyanin, Lidia Maria Gorlich, Basanta Kumar Nandi, Svein Lindal, Ping Yang, Christopher Daniel Anson, Kristin Fanebust Hetland, Pooja Pareek, Roberto Preghenella, Pedro Hugo Ferreira Natal Da Luz, Marek Chojnacki, Janet Elizabeth Seger, Andrea Francescon, Mohammad Ahmad Saleh, Jochen Mathias Thaeder, Rathijit Biswas, Subhasis Chattopadhyay, Alina Gabriela Grigoras, Jeremy John Wilkinson, Ester Anna Rita Casula, Jozef Ferencei, Ionut Cristian Arsene, Sarah Julie Porteboeuf, Jitendra Kumar, Davide Francesco Lodato, Kenneth Francis Read, Zaida Conesa del Valle, Tatsuya Chujo, Jan Cepila, Livio Bianchi, Sarah Louise La Pointe, Minjung Kim, Crispin Williams, Paul Stankus, David Dobrigkeit Chinellato, F. Ronchetti, A. Matyja, Min Jung Kweon, Benjamin Audurier, Federico Cindolo, Xiaowen Ren, Janusz Oleniacz, Chiara Zampolli, Boris Polishchuk, Danthasinghe Piyarathna, Alexander Mamonov, Arturo Tauro, Peter Glassel, Fernando Scarlassara, Lukas Nellen, David Olle Rickard Silvermyr, Gennady Zinovjev, Sadhana Dash, Soyeon Cho, Julius Maximilian Gronefeld, Elena Bruna, Jai Samuel Nielsen Salzwedel, L. Šándor, Christian Bourjau, Grzegorz Andrzej Wilk, Matthias Richter, Igor Lakomov, Podist Kurashvili, Dae Sung Hwang, Y. P. Viyogi, Benjamin Donigus, Tomas Vanat, Maciej Slupecki, Jens Joergen Gaardhoeje, G. Puddu, Jan Jadlovsky, James Declan Mulligan, Alberica Toia, Andile Mothegi Whitehead, Danilo Silva De Albuquerque, Martin Poghosyan, A. R. Reolon, Barbara Jacak, Martin Schmidt, Barbara Guerzoni, Peter Christiansen, Francesco Noferini, Lawrence Pinsky, Hugo Denis Antonio Pereira Da Costa, Alexander Akindinov, Magnus Mager, Alexander Philipp Kalweit, Per-Ivar Lønne, Liliet Calero Diaz, Supriya Das, Artur Furs, Helmut Oskar Oeschler, Miguel Angel Diaz Corchero, N. Grion, Mengliang Wang, Esther Montes Prado, Klaus Johannes Reygers, Astrid Morreale, Vladislav Manko, Andrei Ionut Herghelegiu, Heiko Engel, Federico Antinori, Kai Oliver Schweda, Justin Thomas Blair, Sven Gotovac, Bogdan Vulpescu, Francesco Barile, Nachiketa Sarkar, Vladimir Peskov, Enrichetta Maria Fiore, Francesca Carnesecchi, Guy Paic, Yury Sibiryak, D. R. Gangadharan, Preeti Dhankher, Michal Kopcik, Michael Andreas Winn, Tsubasa Okubo, Sonia Parmar, Gerardus Nooren, Gideon Francois Steyn, Jan Musinsky, Ombretta Pinazza, Henrique Jose Correia Zanoli, Sampo Saarinen, M. Mohisin Khan, I. Berceanu, Borge Svane Nielsen, Raul Tonatiuh Jimenez Bustamante, Pietro Antonioli, Hiroki Yokoyama, Zabulon Vilakazi, Luisa Cifarelli, Barbara Ewa Erazmus, Maria Nicassio, Alexander Borissov, Tomas Wilhelm Snellman, Ana Maria Marin, Rajendra Nath Patra, Serpil Yalcin, I. K. Yoo, Arturo Alejandro Menchaca-Rocha, Daniela Fabris, Irais Bautista Guzman, Ewa Gladysz-dziadus, Jan Rak, Alexandre Shabetai, Rahul Ramachandran Nair, Susanta Kumar Pal, Cristina Terrevoli, M. Ivanov, Ismael Cortes Maldonado, Aditya Nath Mishra, Roberto Divia, W. Park, Michal Broz, Jana Crkovská, Jan de Cuveland, Jinjin Pan, Massimo Masera, Mikhail Zhalov, Evert Anders Stenlund, Andrea Dubla, Leonardo Milano, Marek Bombara, Ernst Hellbar, Maria Vasileiou, Sanjay K. Ghosh, V. Paticchio, Sarita Sahoo, Yvonne Chiara Pachmayer, Vladimir Kovalenko, Boris Batyunya, R. Varma, Edith Zinhle Buthelezi, Diego Mauricio Gomez Coral, A. K. Bhati, Adela Kravcakova, Juan Carlos Cabanillas Noris, Laura Fabbietti, Artem Shangaraev, Mario Ivan Martinez Hernandez, Paola La Rocca, Edmundo Javier Garcia-Solis, Petra Riedler, Ranjit Nayak, Bastian Bathen, Guido Alexander Willems, Prabhat Ranjan Pujahari, Peter Strmen, Xiaoming Zhang, Henrik Qvigstad, Alessandro Feliciello, Katherin Shtejer Diaz, ShinIchi Esumi, Mario Fusco Girard, Giuseppe Simonetti, Orlando Villalobos Baillie, Jan Fiete Grosse-Oetringhaus, Nicole Alice Martin, Vladimir Vechernin, M. Sano, Xu Cai, Anders Nils Erik Oskarsson, Nikolai Smirnov, Mohd Danish Azmi, Maurizio Basile, Slavka Jadlovska, Peter Malzacher, Andreas Morsch, Ivan Ravasenga, D. Domenicis Gimenez, J. Pluta, Evgeny Ryabinkin, Yongwook Baek, Hyungtaik Jung, Daiki Sekihata, Shingo Sakai, Tome Anticic, L. Gruber, Ralf Peter Averbeck, Uwe Westerhoff, Jacobus Willem Van Hoorne, Biswarup Paul, Joakim Nystrand, Hendrik Poppenborg, R. Orava, Se Yong Kim, Sumit Basu, Jussi Samuli Viinikainen, Dmitry Finogeev, Raphael Noel Tieulent, Cynthia Marie Hadjidakis, Igor Altsybeev, Davide Pagano, Natalia Kondratyeva, Mateusz Andrzej Ploskon, Jiri Mares, Marcel Araujo Silva Figueredo, Kgotlaesele Senosi, Michal Sumbera, Jesus Guillermo Contreras Nuno, Eugenio Nappi, Jeremi Niedziela, Dario Berzano, Anju Bhasin, Rene Bellwied, M. Kim, Annika Passfeld, Sedat Altinpinar, Valerii Kondratev, Kristjan Herlache Gulbrandsen, J. W. Harris, Alexey Kurepin, Rigoberto Cruz Albino, Charalampos Kouzinopoulos, T. K. Nayak, Mauro Gallio, Gines Martinez-Garcia, Riccardo Russo, Johannes Peter Wessels, Renato Angelo Ricci, Udo Wolfgang Kebschull, Taku Gunji, Pascal Dupieux, Andrea Dainese, Maciej Pawel Szymanski, Filippo Costa, Sergey Fokin, Lais Ozelin De Lima Pimentel, Michael Linus Knichel, Suh-urk Chung, Paolo Pagano, Sergey Sadovskiy, Dmitry Blau, C. Roy, M. Vala, Alessandra Maria Mazzoni, Antonio Ortiz Velasquez, Francesco Prino, Yury Ryabov, Antonio Juan Rubio Montero, Torsten Alt, Ernesto Belmont Moreno, Mikolaj Krzewicki, M. An, Mahmut Ozdemir, Monika Joanna Jakubowska, Nikola Poljak, Torsten Dahms, Giulio Usai, Dirk Hutter, Sergey Gorbunov, Yuko Sekiguchi, Silvia Masciocchi, Sibaliso Mhlanga, Eric Endress, Shu Li, Sonia Rajput, Ruben Shahoyan, Janka Vrlakova, Anton Alkin, Miljenko Suljic, Julien Charles Hamon, Grazia Luparello, Paraskevi Ganoti, Suharyo Sumowidagdo, Monika Kofarago, Jens Wiechula, Theo Alexander Broker, J. Cerkala, Alexandru Bercuci, Hyeonjoong Kim, Despina Hatzifotiadou, Salvatore Aiola, Raymond James Ehlers, Shuaib Ahmad Khan, A. B. Kurepin, Harald Appelshaeuser, R. Belmont, A. Rachevski, Edgar Perez Lezama, Linus Feldkamp, Andres Sandoval, Arturo Fernandez Tellez, Eleuterio Spiriti, D. Watanabe, Sergio Vergara Limon, Thomas Humanic, Uzma Tabassam, Maximiliano Puccio, Raimond Snellings, Kenta Shigaki, Giuseppe Trombetta, Rune Langøy, Roberta Arnaldi, Ayben Karasu Uysal, Renato Aparecido Negrao De Oliveira, Peter Martin Jacobs, Jon Christopher Wikne, Stefania Bufalino, Alessandro De Falco, Vladimir Nikulin, Maria Haiduc, Boris Hippolyte, Mihai Niculescu, Charles E. Hughes, Ramni Gupta, Predrag Buncic, Laszlo Boldizsar, O. A. Grachov, S. Balasubramanian, Paola Gianotti, Annelies Marianne Veen, Vito Manzari, Alexandru Florin Dobrin, Renaud Vernet, Dhananjaya Thakur, Eleazar Cuautle Flores, Jasper Van Der Maarel, Viktor Riabov, Alexander Deisting, Bharati Naik, Darius Keijdener, Paulus Gerardus Kuijer, Francesco Carena, Victor Gonzalez, Jose Ruben Alfaro Molina, Sean Murray, Giulio Eulisse, Jan Wagner, Kishora Nayak, Goran Simatovic, Ernesto Lopez Torres, Kilian Eberhard Schwarz, Matthias Bonora, Gilda Scioli, Felix Reidt, Pradip Kumar Roy, Raghunath Sahoo, Leonid Vinogradov, Gabor Kiss, Abraham Villatoro Tello, Johanna Stachel, Katarina Krizkova Gajdosova, Valerie Ramillien Barret, Stefano Piano, Serhiy Senyukov, Dmitry Mal'kevich, A. Rossi, Pascal Dillenseger, Oeystein Djuvsland, Cvetan Valeriev Cheshkov, Ildefonso Leon Monzon, Radiy Ilkaev, Kohei Terasaki, Mohammad Tariq, Oliver Busch, V. Petrov, Fouad Rami, Domenico Elia, S. Mahajan, Prabhakar Palni, Vardanush Papikyan, Sorin Ion Zgura, R. Scott, Marielle Chartier, Gyulnara Eyyubova, H. Zhang, Gergoe Hamar, Dagmar Adamová, Michael Henry Oliver, Laurent Bernard Aphecetche, Herve Borel, Hongkai Wang, Bruno Alessandro, H. Caines, Sudhir Raniwala, Tatiana Karavicheva, Subikash Choudhury, Denise Aparecida Moreira De Godoy, Mario Rodriguez Cahuantzi, Nima Zardoshti, Philippe Pillot, Rudiger Haake, Stefano Trogolo, Patrick Simon Reichelt, Sergey Nazarenko, A. Szczepankiewicz, Vasco Miguel Chibante Barroso, Brigitte Cheynis, Carsten Klein, Jihyun Bhom, Hideki Hamagaki, Anselmo Margotti, Petr Zavada, Deepika Rathee, Annalisa Mastroserio, Debasish Das, Pedro Ladron de Guevara, Christina Markert, Ranbir Singh, Mandeep Kour, Krzysztof Marek Sielewicz, Paul Christoph Bätzing, Malgorzata Anna Janik, Boris Teyssier, Do-Won Kim, Ante Bilandzic, Pedro Luis Manuel Podesta Lerma, Alberto Martin Gago Medina, Elisa Laudi, R Jefferson Porter, Oleksandr Kovalenko, Jacek Tomasz Otwinowski, M. R. Cosentino, B. Grynyov, M. Fasel, Alessandra Fantoni, Angela Badala, Andres Gomez Ramirez, Claudiu Cornel Schiaua, Sandra Moretto, Andrea Danu, Guillaume Batigne, Christian Klein-Boesing, Ajay Kumar Dash, Xiaomei Li, Volodymyr Yurchenko, Antonija Utrobicic, Renu Bala, Hartmut Hillemanns, Yosuke Watanabe, Anand Kumar Dubey, David Michael Rohr, Yasuo Miake, Vojtech Petracek, Jose Garabatos Cuadrado, Fabio Filippo Colamaria, Haavard Helstrup, Giacinto de Cataldo, Hans Peter Beck, Hans Martin Ljunggren, Iouri Belikov, Thomas Dietel, R. Grosso, Roman Lietava, Palash Khan, You Zhou, Sohail Musa Mahmood, Christoph Blume, Andrzej Rybicki, Monika Sharma, Vit Kucera, Ciprian Mihai Mitu, Esther Bartsch, Paolo Bartalini, Natasha Sharma, Mikhail Ippolitov, Natalia Zhigareva, Davide Caffarri, Stefano Bagnasco, Johannes Hendrik Stiller, C. Ceballos Sanchez, Jan Pospíšil, Yury Pestov, Sylvain Chapeland, Volodymyr Chelnokov, Rinaldo Rui, Qiye Shou, A. Maire, Anton Jusko, Ivan Kralik, Miroslav Pikna, Mario Sitta, Nicolo Jacazio, Sergey Evdokimov, Michelangelo Agnello, Satoshi Yano, C. Bedda, Daniel Berenyi, Paolo Martinengo, Alessandro Ferretti, Ivonne Alicia Maldonado Cervantes, Anthony Robert Timmins, Adam Ryszard Kisiel, Alberto Collu, Samrangy Sadhu, Guillermo Tejeda Munoz, Costin Grigoras, Gianluca Aglieri Rinella, Daniel Michael Muhlheim, Carlos Duarte Galvan, Naoto Tanaka, Sabyasachi Siddhanta, Buddhadeb Bhattacharjee, Boris Wagner, Alberto Masoni, Chiara Bianchin, Tyler Allen Browning, Fiorella Fionda, Harry Arthur Andrews, Thomas Peitzmann, Marco H. D. van Leeuwen, Shinichi Hayashi, Seongjoo Lee, M. Cherney, Matti Mikael Mieskolainen, Rosi Reed, Alla Maevskaya, Lee Stuart Barnby, Thomas Michael Cormier, Lokesh Kumar, Marco Leoncino, Hua Pei, Piero Giubilato, Xavier Bernard Lopez, Jaroslav Bielcik, Mirko Planinic, Elena Rogochaya, Kirill Lapidus, Enrico Fragiacomo, Anton Andronic, Baldo Sahlmuller, C.J. Schmidt, Yaroslav Berdnikov, Kirill Voloshin, Tinku Sarkar Sinha, Ivan Vorobyev, Victor Jose Gaston Feuillard, Vladimir Ivanov, Didier Alexandre, Alessandro Grelli, Ajay Kumar, Siegfried Valentin Foertsch, Dieter Roehrich, Muhammad Umair Naru, Jaime Norman, Ji-Young Kim, Nicola Bianchi, Madan M. Aggarwal, Neelima Agrawal, Corrado Cicalo, Alexis Jean-michel Mas, Wisla Carena, Martino Gagliardi, Nirbhay Kumar Behera, D. Di Bari, Jihye Song, and M. Irfan
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Muon, Meson, 010308 nuclear & particles physics, 01 natural sciences, Nuclear physics, 0103 physical sciences, Quark–gluon plasma, High Energy Physics::Experiment, Rapidity, Production (computer science), Impact parameter, Nuclear Experiment, 010306 general physics, Nucleon, Energy (signal processing)
Abstract: The inclusive J/$\psi$ production has been studied in Pn-Pb and pp collisions at the centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}}=5.02$ TeV, using the ALICE detector at the CERN LHC. The J/$\psi$ meson is reconstructed, in the centre-of-mass rapidity interval $2.5
Published: 2017
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21. European Approaches to Japanese Language and Linguistics

Author: Patrick Heinrich and Giuseppe Pappalardo
Subjects: Language study, Japanese language, Japanese studies, Sociology, Original research, Linguistics, Focus (linguistics)
Abstract: In this volume European specialists of Japanese language present new and original research into Japanese over a wide spectrum of topics which include descriptive, sociolinguistic, pragmatic and didactic accounts. The articles share a focus on contemporary issues and adopt new approaches to the study of Japanese that often are specific to European traditions of language study. The articles address an audience that includes both Japanese Studies and Linguistics. They are representative of the wide range of topics that are currently studied in European universities, and they address scholars and students alike.
Published: 2020
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22. Monomeric ß-Amyloid Interacts with Type-1 Insulin-Like Growth Factor Receptors to Provide Energy Supply to Neurons

Author: Agata Copani, Ferdinando Nicoletti, Enrico Rizzarelli, Riccardo Vigneri, Sandro Sorbi, Benedetta Nacmias, Silvia Bagnoli, Santina Chiechio, Francesco Attanasio, Giuseppe Pappalardo, Paola Di Pietro, Carla Busceti, Giuseppe Battaglia, Filippo Caraci, Giuseppe Pandini, Marianna Flora Tomasello, and Maria Laura Giuffrida
Published: 2020
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23. NausicaApp: A Hybrid Decentralized Approach to Managing Covid-19 Pandemic at Campus Premises

Author: Fabio Merola, Fabrizio Billeci, Emiliano Tramontana, Giuseppe Criscione, Giuseppe Pappalardo, and Giovanni Marotta
Subjects: Coronavirus disease 2019 (COVID-19), Computer science, 05 social sciences, 050801 communication & media studies, 020206 networking & telecommunications, 02 engineering and technology, Tracing, Computer security, computer.software_genre, law.invention, Bluetooth, 0508 media and communications, law, Server, 0202 electrical engineering, electronic engineering, information engineering, Task analysis, computer
Abstract: Several contact-tracing app-based solutions have been proposed to alert app users who have previously encountered a Covid-19-positive user. In most countries, a state-sponsored app has been made available to let citizens who install it on their phone monitor inter-personal contacts. The particular scenario considered in this work aims to support tracing within a university campus. For this, an alternative solution is proposed, based on a hybrid decentralized approach, that traces people who have been present in the same environment within some meaningful time interval. Thus, tracing goes beyond direct contact between persons. Our solution can also monitor crowd gathering on campus premises.The proposed Android app senses surrounding WiFi signals and uses them to obtain the user's absolute location. The app then securely sends an anonymized presence data object to the server. Thanks to data thus gathered, as soon as a user has reported herself as Covid-19-positive, all apps will be alerted by the server and receive anonymous data to determine whether their users happened to be in the same environment as the Covid-positive one. We believe our approach to be both effective, for it eschews weaknesses and limitations of Bluetooth-based solutions, and viable, for the experiments reported have proved WiFi sensing-based localization to be accurate enough.
Published: 2020

24. Tau/A beta chimera peptides: Evaluating the dual function of metal coordination and membrane interaction in one sequence

Author: Rita Tosto, Giuseppe Di Natale, Michele Sciacca, Giuseppe Pappalardo, and Danilo Milardi
Subjects: Circular dichroism, Amyloid, Amyloid beta, Tau protein, tau Proteins, 010402 general chemistry, 01 natural sciences, Biochemistry, Fluorescence, Inorganic Chemistry, Coordination Complexes, Amyloids, Humans, Chelation, Metal ions, Lipid bilayer, Amyloid beta-Peptides, Membranes, biology, 010405 organic chemistry, Chemistry, Membranes, Artificial, 0104 chemical sciences, Peptide Conformation, Zinc, Membrane, Biophysics, biology.protein, Peptides, Copper
Abstract: Several abnormal events may concur as major risk factors for Alzheimer's disease (AD) pathogenesis. For instance, dysregulation of brain's metal homeostasis and amyloid-mediated membrane damage are established toxic mechanisms causing neuronal death. In this study, we assess the amyloidogenic propensity and membranedamage effects, either in the presence or in absence of metal ions, of two newly synthesized bifunctional peptides. These were designed to comprise a metal chelating N-terminus region derived from Tau protein namely the Tau9-16 (EVMEDHAG) or Tau26-33 (QGGYTMHQ) sequences, merged with the C-terminal hydrophobic region analogous to the Amyloid beta (A beta) 16-20 aminoacid sequence KLVFF (KL). Comparative circular dichroism or fluorescence experiments were carried out to look at the peptide conformation, fibril formation and membrane affinity of Tau9-16KL and Tau26-33KL peptides. We found that Tau9-16KL and Tau26-33KL perturb the fibrillogenic process of A beta(1-40). Furthermore Cu(II) and, to a lower extent, Zn(II) induced conformational changes Tau26-33KL both in water and in membrane-mimicking environment. By contrast, due to a different metal coordination mode we observed for Tau9-16KL an unstructured peptide conformation in all the experimental conditions. Unlike aqueous solution, a certain propensity to form amyloid structures at the lipid membrane interface clearly emerged for both the peptides. However, the two peptides exhibit a different capability to elicit membrane damage depending on the presence or absence of metal ions. Tau9-16KL and Tau26-33KL can be used as peptide-based molecular systems able to interfere with the metal dependent A beta/Tau cross-seeded generation of membrane active amyloid species.
Published: 2020
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25. Copper(II) Coordination Abilities of the Tau Protein's N-Terminus Peptide Fragments: A Combined Potentiometric, Spectroscopic and Mass Spectrometric Study

Author: Márton, Lukács, Györgyi, Szunyog, Ágnes, Grenács, Norbert, Lihi, Csilla, Kállay, Giuseppe, Di Natale, Tiziana, Campagna, Valeria, Lanza, Giovanni, Tabbi, Giuseppe, Pappalardo, Imre, Sóvágó, and Katalin, Várnagy
Subjects: Binding Sites, Coordination Complexes, Potentiometry, tau Proteins, Amino Acid Sequence, Copper, Mass Spectrometry, Peptide Fragments
Abstract: Copper(II) complexes of the N-terminal peptide fragments of tau protein have been studied by potentiometric and various spectroscopic techniques (UV-vis, CD, ESR and ESI-MS). The octapeptide Tau(9-16) (Ac-EVMEDHAG-NH
Published: 2019

26. Comparison of Centella with Flavonoids for Treatment of Symptoms in Hemorrhoidal Disease and After Surgical Intervention: A Randomized Clinical Trial

Author: Chiaretti M, Michele Dello Spedale Venti, Giuseppe Pappalardo, Annalisa Italia Chiaretti, and Danilo Alunni Fegatelli
Subjects: 0301 basic medicine, Male, Anus, flebotonici, lcsh:Medicine, medicine.disease_cause, Gastroenterology, Severity of Illness Index, Group B, law.invention, Anal diseases, 0302 clinical medicine, Randomized controlled trial, law, lcsh:Science, malattie ano, Multidisciplinary, Thrombosis, Combined Modality Therapy, Treatment Outcome, 030220 oncology & carcinogenesis, Randomized controlled trials, Female, Irritation, centella asiatica, Hemorrhoidectomy, medicine.medical_specialty, Diet therapy, Hemorrhoids, Article, 03 medical and health sciences, Centella, Internal medicine, Severity of illness, medicine, emorroidi, Humans, irritazione anale, dolore dopo emorroidectomia, Flavonoids, Postoperative Care, business.industry, lcsh:R, flavonoidi, sanguinamento anale sanguinamento emorroidario, trombosi emorroidaria, medicine.disease, Fibrosis, 030104 developmental biology, Histopathology, lcsh:Q, business, Diet Therapy
Abstract: Phlebotonics’ effects were evaluated to reduce time-to-stop bleeding and anal irritation in 130 patients who complained of hemorrhoidal disease (HD); bleeding and pain after hemorrhoidectomy (31 patients) and hemorrhoidal thrombosis (34 patients) in the short time. Sixty patients were randomized to receive the routine treatment (both conservative and surgical) (control Group C). The treated group (both conservative and surgical) was divided into two subgroups: one treated with flavonoids (Group A, n = 73), the other with Centella (Group B, n = 66). Time-to-stop bleeding was checked at baseline and checkups (0 up to day 42). Healing was estimated with Kaplan-Meier method, the Kruskal-Wallis test estimated changes in the VAS scores. The HD median time-to-stop bleeding was 2 weeks for Groups A and B; 3 weeks for Group C. VAS scores comparison among Groups (irritation): A vs C, p = 0.007; B vs C, p = 0.041; and A vs B, p = 0.782 resulted respectively. As for operated hemorrhoids, the time-to-stop bleeding was 3 and 4 weeks in Groups A and B and 5 in Group C. Histopathology showed an association between flavonoids and piles’ fibrosis (p = 0.008). Phlebotonics in HD, as well as after surgery, showed significant beneficial effects. Flavonoids are the most effective phlebotonics against bleeding and anal irritation.
Published: 2019

27. New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity

Author: Enrico Rizzarelli, Antonio Magrì, V. G. Nicoletti, Diego La Mendola, and Giuseppe Pappalardo
Subjects: 0301 basic medicine, Circular dichroism, Stereochemistry, copper, cytotoxicity, diabetes, peptides, potentiometry, Chemistry (all), Inorganic chemistry, Amylin, Peptide, 010402 general chemistry, copper, cytotoxicity, diabetes, peptides, 01 natural sciences, Protein Structure, Secondary, Catalysis, Polyethylene Glycols, 03 medical and health sciences, Residue (chemistry), chemistry.chemical_compound, Coordination Complexes, Animals, Humans, Imidazole, Histidine, Protein secondary structure, chemistry.chemical_classification, Binding Sites, Chemistry, Organic Chemistry, General Chemistry, Islet Amyloid Polypeptide, Rats, 0104 chemical sciences, 030104 developmental biology, Copper ion binding, Thermodynamics, Protein Binding
Abstract: Type-2 diabetes (T2D) is considered to be a potential threat on a global level. Recently, T2D has been listed as a misfolding disease, such as Alzheimer's and Parkinson's diseases. Human islet amyloid polypeptide (hIAPP) is a molecule cosecreted in pancreatic β cells and represents the main constituent of an aggregated amyloid found in individuals affected by T2D. The trace-element serum level is significantly influenced during the development of diabetes. In particular, the dys-homeostasis of Cu(2+) ions may adversely affect the course of the disease. Conflicting results have been reported on the protective role played by complex species formed by Cu(2+) ions with hIAPP or its peptide fragments in vitro. The histidine (His) residue at position 18 represents the main binding site for the metal ion, but contrasting results have been reported on other residues involved in metal-ion coordination, in particular those toward the N or C terminus. Sequences that encompass regions 17-29 and 14-22 were used to discriminate between the two models of the hIAPP coordination mode. Due to poor solubility in water, poly(ethylene glycol) (PEG) derivatives were synthesized. A peptide fragment that encompasses the 17-29 region of rat amylin (rIAPP) in which the arginine residue at position 18 was substituted by a histidine residue was also obtained to assess that the PEG moiety does not alter the peptide secondary structure. The complex species formed by Cu(2+) ions with Ac-PEG-hIAPP(17-29)-NH2 , Ac-rIAPP(17-29)R18H-NH2 , and Ac-PEG-hIAPP(14-22)-NH2 were studied by using potentiometric titrations coupled with spectroscopic methods (UV/Vis, circular dichroism, and EPR). The combined thermodynamic and spectroscopic approach allowed us to demonstrate that hIAPP is able to bind Cu(2+) ions starting from the His18 imidazole nitrogen atom toward the N-terminus domain. The stability constants of copper(II) complexes with Ac-PEG-hIAPP(14-22)-NH2 were used to simulate the different experimental conditions under which aggregate formation and oxidative stress of hIAPP has been reported. Speciation unveils: 1) the protective role played by increased amounts of Cu(2+) ions on the hIAPP fibrillary aggregation, 2) the effect of adventitious trace amounts of Cu(2+) ions present in phosphate-buffered saline (PBS), and 3) a reducing fluorogenic probe on H2 O2 production attributed to the polypeptide alone.
Published: 2016
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28. Cyclodextrin Nanomagnetes Decorated With Peptides: From Abeta-Amyloid Detection To Theranostic

Author: Antonino Mazzaglia, Roberto Zagami, Rita Tosto, Giuseppe Di Natale, Alek Dediu, Noberto Micali, and Giuseppe Pappalardo.
Subjects: Cyclodextrins, Theranostic, Magnetic Nanoparticles
Abstract: Magnetic nanoparticles (MNPs) are widely utilized in magnetic-field-assisted bio-separation, bio- interaction, imaging and drug delivery, due to their large surface area and easy manipulation by an external magnetic force. MNPs, stabilized with different capping agents and incorporating drugs, were designed as nanotheranostic. In this context, cyclodextrin-based MNPs offer a multipurpose chance in detection, therapy and imaging, since cyclodextrins (CDs) can strongly entrap in its cavity hydrophobic guests to optimize molecular recognition of biomarkers or for sustained therapeutic action in the site where they are directed with the help of the magnetic field and / or serving as contrast agents in magnetic resonance imaging (MRI) . Amphiphilic cyclodextrin (aCD) are efficaciously engaged to entrap and control deliver of drugs and diagnostic probes [1]. Here we propose MNP covered with aCD nanomagnets (aCD is heptakis (2-oligo(ethyleneoxide)-6-hexadecylthio-)-?- CD (SC16OH)) (MNP@SC16OH) and tailored with Adamantanil-(PEG)4-KLVFF (Ada-Pep) for recognition and detection of Amyloid-?(1-42) protein (A?(1-42)). MNP@SC16OH/Ada-Pep were prepared by hydration of an organic film of Ada-Pep with a dispersion of pre-made-up MNP@SC16OH. Hence, modified MNPs were isolated by magnetic-filed separation, centrifugation and fully characterized [2]. Furthermore, we investigated the ability of system to fish out A?(1-42) from samples prepared in aqueous solutions and analysed by MALDI-TOF MS. Our results indicate that in our experimental conditions the nanomagnets can perform an unbiased A?(1-42)-targeted fishing. Moreover the effect of nanomagnetes in delivery of anticancer drugs as sorafenib in hepatocellular carcinoma (HCC) cells as well as in in vitro enhancement of MRI relaxivity was investigated [3]. Altogether, results indicate the potential utilize of these nanomagnets based on cyclodextrins as therapeutic and imaging agents.
Published: 2019

29. Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy

Author: Valentina Oliveri, Giuseppe Pappalardo, Graziella Vecchio, Maurizio Viale, Valentina Giglio, Rita Tosto, Maria Addolorata Mariggiò, and Irena Maric
Subjects: 0301 basic medicine, carbohydrates, Nanoparticle, Antineoplastic Agents, Sequence (biology), 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, polycyclic compounds, Humans, Pharmacology (medical), Doxorubicin, Cellulose, Cytotoxicity, Cell Proliferation, Cancer, Pharmacology, chemistry.chemical_classification, Cyclodextrins, Drug Carriers, Cyclodextrin, Molecular mass, Carbohydrates, Nanoparticles, Peptides, Oncology, technology, industry, and agriculture, Combinatorial chemistry, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, peptides, Nanocarriers, Oligopeptides, medicine.drug
Abstract: Polymeric cyclodextrin-based nanoparticles are currently undergoing clinical trials as nanotherapeutics. Using a non-covalent approach, we decorated two cross-linked cyclodextrin polymers of different molecular weights with an RGD peptide derivative to construct a novel carrier for the targeted delivery of doxorubicin. RGD is the binding sequence for the integrin receptor family that is highly expressed in tumour tissues. The assembled host-guest systems were investigated using NMR and DLS techniques. We found that, in comparison with free doxorubicin or the binary complex doxorubicin/cyclodextrin polymer, the RGD units decorating the cyclodextrin-based nanosystems improved the selectivity and cytotoxicity of the complexed doxorubicin towards cultured human tumour cell lines. Our results suggest that the nanocarriers under study may contribute to the development of new platforms for cancer therapy.
Published: 2019
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30. Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-?-cyclodextrin: A comparative study with cyclodextrin complexes

Author: Giuseppe Pappalardo, Alessandro Giuffrida, Giuseppe Maccarrone, Sara Merlo, Mimimorena Seggio, Santina Chiechio, Carmela Parenti, and Annalinda Contino
Subjects: Drug, Male, Cell Survival, media_common.quotation_subject, Analgesic, Pharmaceutical Science, Pain, 02 engineering and technology, Pharmacology, Duloxetine Hydrochloride, 030226 pharmacology & pharmacy, Cyclodextrin derivatives Inclusion complexes, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Medicine, Duloxetine, Animals, Humans, Duloxetine, Cyclodextrin derivatives Inclusion complexes, Drug delivery, CYP2D6, Pain, Depression, Cognitive decline, Cyclodextrin derivatives, CYP2D6, Depression, Drug delivery, Inclusion complexes, media_common, Analgesics, Cyclodextrins, business.industry, Chronic pain, 021001 nanoscience & nanotechnology, medicine.disease, Tolerability, chemistry, Cytochrome P-450 CYP2D6, Caco-2 Cells, 0210 nano-technology, Reuptake inhibitor, business, Tail flick test
Abstract: Chronic pain represents one of the most important public health problems, with a great prevalence of comorbidity with depression and cognitive decline. Antidepressants such as duloxetine, a serotonin-norepinephrine reuptake inhibitor, represent an essential part of the therapeutic strategy for chronic pain management in addition to classical analgesics. Duloxetine is endowed with good efficacy and a good profile of safety and tolerability. Yet, duloxetine is metabolized by the cytochrome P450 system 2D6 and 1A2 (CYP2D6 and CYP1A2) and it exhibits moderate inhibitory activity on CYP2D6, resulting in side effects and metabolic interactions that may occur on a long term therapeutic schedule. Cyclodextrins (CyDs) are used in pharmaceutical applications for numerous purposes, including the improvement of drug bioavailability. In order to evaluate their effects on the activity of duloxetine, we first spectrophotometrically studied the host–guest complexes obtained combining duloxetine and different β-CyD derivatives (β-CyD, β-CyDen-c-(Glu-Glu), and succinyl-β-CyD) and then performed in vivo and in vitro studies. Among duloxetine/CyDs complexes, succinyl-β-CyD ameliorated the analgesic activity of duloxetine in the tail flick test and in the formalin test in mice and significantly protected the drug from CYP2D6 metabolism.
Published: 2019
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31. The ability of the NiSOD binding loop to chelate zinc(ii): The role of the terminal amino group in the enzymatic functions

Author: Tamás Gajda, Imre Sóvágó, Norbert Lihi, Giuseppe Pappalardo, Katalin Várnagy, András Kolozsi, Gizella Csire, and István Fábián
Subjects: Stereochemistry, chemistry.chemical_element, Peptide, Zinc, metal complexes, 010402 general chemistry, Ligands, 01 natural sciences, Inorganic Chemistry, Deprotonation, Coordination Complexes, Nickel, Side chain, Chelation, Amino Acid Sequence, Binding site, Amines, Amino Acids, Peptide sequence, Chelating Agents, chemistry.chemical_classification, Binding Sites, Molecular Structure, 010405 organic chemistry, Hydrogen-Ion Concentration, 0104 chemical sciences, stability constants, chemistry, peptides, Thermodynamics, Protein Binding
Abstract: Equilibrium and detailed spectroscopic characterization of zinc(ii) complexes with NiSOD binding loop and their related model fragments are reported in the whole investigated pH-range. The zinc(ii) complexes of L1 (HCDLPCGVY-NH2), L2 (Ac-HCDLPCGVY-NH2) and L3 (HCDLACGVY-NH2) and the nickel(ii) and zinc(ii) complexes of L4 (HCDLPCG-NH2) were studied by pH-potentiometric and several spectroscopic methods. The results indicated that the macrochelate coordinated zinc(ii) complexes are dominant in a whole pH-range and the side chain donors of the peptides are involved in the metal binding. Therefore, the deprotonation and coordination of the peptide backbone occur only in a strongly alkaline solution. The acetylation of the peptide amino terminus (L2) significantly enhances the zinc(ii) binding ability compared to the corresponding nickel(ii) complexes. L2 complexes of zinc(ii) are 2 or 3 orders of magnitude more stable than the corresponding nickel(ii) complexes. This effect clearly shows the crucial role of the terminal amino group in the nickel binding for the NiSOD enzyme.
Published: 2019
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32. Copper(<scp>ii</scp>) coordination properties of the Aβ(1–16)2peptidomimetic: experimental evidence of intermolecular macrochelate complex species in the Aβ dimer

Author: Giuseppe Di Natale, Daniele Sanna, Alessandro Sinopoli, Imre Sóvágó, Ágnes Grenács, and Giuseppe Pappalardo
Subjects: chemistry.chemical_classification, copper(II) complexes o peptide o Amyloid o macrochelate o mass spectrometry, 010405 organic chemistry, Chemistry, Stereochemistry, Peptidomimetic, Metal ions in aqueous solution, Dimer, Peptide, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, Metal, chemistry.chemical_compound, Residue (chemistry), visual_art, Materials Chemistry, visual_art.visual_art_medium, Moiety, Imidazole
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of extracellular aggregates of amyloid-b peptides (Ab). Different metal ions accumulate within amyloid deposits, which suggests an involvement of metal ions in AD pathogenesis. Cu(II)-induced Ab neurotoxicity might result from changes in the coordination of the metal ion during Ab oligomerization or from different peptide/ metal ratios. Little is known on the Cu(II) complex with low-molecular-weight Ab species. Here, we report our results on the Cu(II) coordination modes with a synthetic Ab(1-16) dimer where the C-terminal 16Lys residue, of each peptide chain, is linked to a N,N-bis[(3-amino)propyl]glycine bearing a PEG moiety at the C-terminus. The formation of macrochelate complex species with the involvement of imidazole nitrogen donor atoms of His13 and His14, during copper(II) binding at physiological pH and low metal to peptide ratios, is observed.
Published: 2016
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33. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1–42)-induced toxicity

Author: Rosario Pignatello, Alessandro Sinopoli, Rita Tosto, Filippo Drago, Filippo Caraci, Salvatore Guccione, Emanuele Pirrone, Livia Basile, Maria Laura Giuffrida, Agata Copani, Alessandro Giuffrida, and Giuseppe Pappalardo
Subjects: Amyloid, Monoamine Oxidase Inhibitors, Monoamine oxidase, medicine.drug_class, Pharmacology, Neuroprotection, Anti-aggregant activity, medicine, Animals, Cells, Cultured, Cerebral Cortex, Neurons, Monoamine oxidase inhibitor, Amyloid beta-Peptides, Cell Death, Chemistry, Tranylcypromine, Neurodegeneration, Antidepressants, Alzheimer's disease, medicine.disease, Amides, Peptide Fragments, Rats, Neuroprotective Agents, amyloid beta aggregation, MAO, Toxicity, Antidepressant, medicine.drug
Abstract: Monoamine oxidase (MAO) enzymes play a central role in the pathogenesis of Alzheimer's disease (AD) and MAO inhibitors (MAOIs) are antidepressant drugs currently studied for theft neuroprotective properties in neurodegenerative disorders. In the present work MAOIs such as tranylcypromine [trans(+)-2-phenylcyclopropanamine, TCP] and its amide derivatives, TCP butyramide (TCP-But) and TCP acetamide (TCP-Ac), were tested for their ability to protect cortical neurons challenged with synthetic amyloid-beta (A beta)-(1-42) oligomers (100 nM) for 48 h. TCP significantly prevented A beta-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 mu M. TCP-But was maximally protective in mixed neuronal cultures at 10 mu M, a lower concentration compared to TCP, whereas the new derivative, TCP-Ac, was more efficacious than TCP and TCP-But and significantly protected cortical neurons against A beta toxicity at nanomolar concentrations (100 nM). Experiments carried out with the Thioflavin-T (Th-T) fluorescence assay for fibril formation showed that TCP and its amide derivatives influenced the early events of the A beta aggregation process in a concentration-dependent manner. TCP-Ac was more effective than TCP-But and TCP in slowing down the A beta (1-42) aggregates formation through a lengthening at the lag phase. In our experimental model coincubation of A beta(1-42) oligomers with TCP-Ac was able to almost completely prevent A beta-induced neurodegeneration. These results suggest that inhibition of A beta oligomenmediated aggregation significantly contributes to the overall neuroprotective activity of TCP-Ac and also raise the possibility that TCP, and in particular the new compound TCP-Ac, might represent new pharmacological tools to yield neuroprotection in AD. (C) 2015 Elsevier B.V. All rights reserved.
Published: 2015
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34. A General Powerful Graph Pattern Matching System for Data Analysis

Author: Emiliano Tramontana, Andrea Fornaia, Giuseppe Pappalardo, and Misael Mongiovì
Subjects: Theoretical computer science, Computer science, Subgraph isomorphism problem, Network data, 02 engineering and technology, Graph, 020204 information systems, Subgraph isomorphism, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Network analysis, Graph pattern matching, MathematicsofComputing_DISCRETEMATHEMATICS, Graph pattern matching, Network analysis, Subgraph isomorphism
Abstract: Graph pattern matching is a powerful mechanism for searching on network data. Most of the graph pattern matching tools available are based on subgraph isomorphism, i.e. finding a one-to-one correspondence between nodes of a query graph and nodes of a target graph. Often this approach is not flexible enough, since it does not allow the query to represent sets of nodes of any size that share the same profile of connectivity. We propose a novel powerful graph matching approach that overcomes the existing limits and allows the user to define complex patterns in a simple and intuitive way. In our approach, queries are expressed as graphs, whose nodes and edges specify structural constraints and filtering criteria. We show that, despite its simplicity, the proposed approach can solve a large variety of practical problems.
Published: 2018

35. Program Analysis and Graph Pattern Matching to Reveal Modularity and Potential for Parallelism

Author: Misael Mongiovì, Emiliano Tramontana, Andrea Fornaia, and Giuseppe Pappalardo
Subjects: parallelism, Theoretical computer science, Computer science, data dependence, External Data Representation, Static analysis, Static analysis, data dependence, mining software repositories, refactoring, parallelism, big data, Program analysis, big data, Graph (abstract data type), Software system, Pattern matching, Graph pattern matching, refactoring, mining software repositories
Abstract: Large software systems need to be evolved to cope with their changing environment, e.g. to incorporate new functionalities, or to better use the underlying hardware. This paper proposes an approach to reveal which parts of a system can be isolated in a module, and which parts can potentially run in parallel. We use a graph representation for the data extracted from a target software system and for the queries that express our desired analyses. Then we employ a matching framework performing queries on the target graph. The data representation is highly flexible and supports several analyses, shown in our experiments.
Published: 2018

36. Sociolinguistic factors affecting vowel devoicing in spontaneous Japanese. A preliminary corpus-based analysis

Author: Giuseppe Pappalardo
Subjects: Vowel devoicing, sociolinguistic variation, extra-linguistic factors, oral corpora, spontaneous Japanese, Vowel devoicing, General Medicine, spontaneous Japanese, Linguistics, Style (sociolinguistics), Settore L-OR/22 - Lingue e Letterature del Giappone e della Corea, Variation (linguistics), sociolinguistic variation, Sociological Factor, Vowel, extra-linguistic factors, Corpus based, Voice, Psychology, oral corpora
Abstract: Maekawa and Kikuchi (2005) used the Corpus of Spontaneous Japanese (CSJ) to analyse the frequency of vowel devoicing in different phonological environments. According to their analysis, the devoicing rate is highest when a fricative is followed by a stop and lowest when an affricate is followed by a fricative. Moreover, the results of their study suggest that devoicing also occurs in atypical environments, as in non-close vowels and in contexts where a vowel is followed by a voiced consonant. However, the frequency of devoicing is conditioned not only by phonological factors but, at a certain extent, also by extra-linguistic and sociological factors such as age, gender and speech style. This paper aims to analyse the sociolinguistic variation of vowel devoicing in spontaneous Japanese using the CSJ-Core consisting of about 45 hours of speech, all of which have been (sub-)phonemically segmented. Age, gender and speech style variation has been analysed for different phonological environments. Particular attention will be given to atypical environments which showed a higher rate of variability.
Published: 2018

37. Potential therapeutics of Alzheimer's diseases: New insights into the neuroprotective role of trehalose-conjugated beta sheet breaker peptides

Author: Giuseppe Pappalardo, Stefania Zimbone, Enrico Rizzarelli, Maria Laura Giuffrida, Marianna Flora Tomasello, Francesco Bellia, and G. Di Natale
Subjects: 0301 basic medicine, Organic Chemistry, Biophysics, Beta sheet, HR-MS, Conjugated system, Biochemistry, Trehalose, Neuroprotection, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, NMDA excitotoxicity, 030104 developmental biology, chemistry, fluorescence, amyloids
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure. The conversion of the amyloid-beta (A beta) peptide into soluble oligomers has recently become recognized as playing a key role in AD pathogenesis. Thus, prevention and therapeutic strategies against AD focus on modulating A beta levels aiming also at stabilizing A beta's monomeric status or inhibiting the peptide's self-assembly. Peptide-based inhibitors may provide a reasonable alternative to chemical small molecules. We report herein further insights into the neuroprotective action of two trehalose-conjugated peptides able to counteract the A beta's oligomers associated neuronal toxicity. In addition, the Trehalose-Succinyl-LPFFD-NH2 (Th-Succ-LPFFD-NH2) and Ac-LPFFD-Trehalose (Ac-LPFFD-Th) derivatives protect neuronal cells from excitotoxic insult mediated by NMDA and evoke by themselves pro-survival signal pathways as an additional cell protective action. UHPLC-HRMS experiments suggest that a possible step associated to the neuroprotective mechanism involves the cell uptake and/or a membrane interaction of the studied peptides.
Published: 2018
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38. Multiplicity dependence of jet-like two-particle correlation structures in p–Pb collisions at sNN=5.02 TeV

Author: Stefano Piano, Shingo Sakai, Taesoo Kim, A. Zichichi, Eleazar Cuautle, Sun Kun Oh, Thorsten Sven Kollegger, Domenico Colella, David Michael Rohr, Manuel Colocci, Martin Andreas Volkl, C. Alves Garcia Prado, Sona Pochybova, Roy Crawford Lemmon, A. Szanto de Toledo, Pascal Dillenseger, C. G. Yaldo, Andrea Festanti, Jun Takahashi, Anik Gupta, Vladimir Samsonov, Jana Bielcikova, Christine Nattrass, Lucile Ronflette, Sergey Kiselev, L. Calero Diaz, Luciano Musa, Fabio Filippo Colamaria, Sebastian Kalcher, Vardanush Papikyan, R. Scott, I. Martashvili, Florian Painke, A. J. Rubio Montero, Haavard Helstrup, Hans Peter Beck, Bjarte Kileng, T. Pawlak, Francesco Noferini, J. Porter, C. Baumann, Alessandra Lattuca, Trine Spedstad Tveter, Ivan Kisel, Sang Un Ahn, Valentina Zaccolo, Alexei Khanzadeev, P. Pillot, Rosario Turrisi, F. Rettig, Mengliang Wang, Ken Oyama, Iouri Belikov, Thomas Dietel, Rama Chandra Baral, Jean-Yves Grossiord, Jai Samuel Nielsen Salzwedel, Supriya Das, Peter Graham Jones, Dagmar Adamová, Hans Rudolf Schmidt, J. de Cuveland, H. Bøggild, Roman Lietava, Sanjib Muhuri, M. Kim, A. Margotti, Marc Weber, F. Baltasar Dos Santos Pedrosa, D. Miśkowiec, J. Mlynarz, Vladimir Ivanov, Rainer Arno Ernst Renfordt, Andrey Reshetin, Vladislav Manko, Smbat Grigoryan, Rainer Martin Schicker, Alexandru Florin Dobrin, Y. Martynov, Marcello Lunardon, Ilya Selyuzhenkov, Bogdan Vulpescu, Z. Buthelezi, Zhuo Zhou, J. Lehnert, Petr Nomokonov, Lukasz Kamil Graczykowski, Alina Gabriela Grigoras, Livio Bianchi, I. Garishvili, Federico Cindolo, L. Šándor, Gideon Francois Steyn, M. Mohisin Khan, I. Berceanu, Borge Svane Nielsen, Sohail Musa Mahmood, Vladimir Peskov, Martin Schulc, Rashmi Raniwala, Jørgen André Lien, Artem Shangaraev, Alexander Nyanin, Jochen Gerhard, Andrzej Deloff, D. Felea, J. Book, Michal Broz, C. Pajares, Jacek Tomasz Otwinowski, M. R. Cosentino, Paolo Giubellino, T. Haaland, Philippe Crochet, Nicole Alice Martin, Cenek Zach, Madan M. Aggarwal, Ali Zaman, Marco Marquard, Jean-Pierre Revol, Andre Augustinus, J. Yi, Claude Andre Pruneau, Amalia Pop, Rachid Guernane, Chitrasen Jena, Cynthia Marie Hadjidakis, Sylvain Chapeland, Raimond Snellings, Rishat Sultanov, L. Manceau, Imrich Szarka, Nicole Bastid, Daniel Lohner, Daniel Michael Muhlheim, Basanta Kumar Nandi, Svein Lindal, Ping Yang, Kristin Fanebust Hetland, Svetlana Kushpil, I. K. Yoo, M. Morando, Bruno Espagnon, Xianguo Lu, Raphaelle Marie Bailhache, Vikas Singhal, Roberto Barbera, Elena Botta, M. Spyropoulou-Stassinaki, Valeria Muccifora, Enrichetta Maria Fiore, Andrea Alici, I. León Monzón, Jozef Ferencei, Anders Nils Erik Oskarsson, R. D. Majka, Maurizio Basile, M. Bogolyubsky, M. Gumbo, HT Yang, Beomkyu Kim, Neelima Agrawal, Corrado Cicalo, J. D. Tapia Takaki, S. Dørheim, I. Lakomov, Yves Roland Schutz, Cristian Andrei, Venelin Anguelov, Nazeer Ahmad, E. López Torres, A. Kolojvari, C. Cavicchioli, Frederick Kramer, Giuseppe Pappalardo, Marie Germain, Ali Okatan, Christoph Mayer, Andrea Rossi, A. K. Dutta Majumdar, A. Fernández Téllez, Martin Poghosyan, Natalia Kondratyeva, Mateusz Andrzej Ploskon, Alexandre Shabetai, Antoine Xavier Lardeux, Sabyasachi Siddhanta, Marian Krivda, Zhongbao Yin, Dmitry Yurevich Peresunko, Ankhi Roy, Ermanno Vercellin, I. S. Zgura, Volodymyr Chelnokov, Rinaldo Rui, H. Pereira Da Costa, Vladimir Kaplin, You Zhou, D. A. Moreira De Godoy, Claudiu Cornel Schiaua, Sandra Moretto, Jihyun Bhom, A. M. Gago, Sanjay K. Ghosh, Youngil Kwon, Andrey Zarochentsev, Grzegorz Andrzej Wilk, Matthias Richter, Latchezar Betev, Wisla Carena, Martino Gagliardi, R. A. Soltz, Marek Kowalski, A. Masoni, Somnath Kar, Ulrich Michael Frankenfeld, Maksym Zyzak, Ewa Gladysz-dziadus, Jan Rak, Yu. V. Kharlov, Joel Anthony Mazer, Francesca Bellini, Jogender Saini, J. J. Gaardhøje, Alexey Bogdanov, Hongbo Zhu, Ian Gardner Bearden, S. Yasnopolskiy, Alexey Kuryakin, Filimon Roukoutakis, M. Fusco Girard, T. Djuvsland, Sergey Evdokimov, Jason Kamin, Andry Malala Rakotozafindrabe, Andrea Danu, P. Ladron de Guevara, Guillaume Batigne, G. E. Bruno, M. A. Mazzoni, Artem Konevskikh, Leonid Vinogradov, Gabor Kiss, D. W. Kim, G. Herrera Corral, Liudmila Malinina, Tomoya Tsuji, Dmitry Blau, C. Roy, Yorito Yamaguchi, Filippo Costa, Debojit Sarkar, B. Ghidini, J. S. Kim, Friederike Bock, M. A. Lisa, Gyula Bencedi, Fernando Scarlassara, Sergey Gorbunov, R. T. Jimenez Bustamante, M. Heide, M. Petris, Rosario Nania, Bogdan Theodor Rascanu, D. Di Bari, Jihye Song, Adela Kravcakova, Johanna Stachel, Lawrence Pinsky, Alexander Vodopyanov, Jochen Klein, Tatjana Susa, Renu Bala, Fedor Guber, Constantinos Loizides, Tuva Ora Herenui Richert, Markus Bernhard Zimmermann, Soren Pontoppidan Sorensen, Petra Riedler, Jiri Kral, Peter Glassel, M. Bach, H. J. Jang, Oliver Busch, Alexandr Tumkin, S. Li, Linus Feldkamp, Andres Sandoval, M. Irfan, V. Kadyshevskiy, Martin Vala, Gennady Zinovjev, V. Catanescu, Iosif Legrand, Maitreyee Mukherjee, Sadhana Dash, Dieter Røhrich, Christian Holm Christensen, M. E. Connors, Xiaoming Zhang, Annalisa Mastroserio, Debasish Das, Susanta Kumar Pal, W. Park, Rudiger Haake, Krzysztof Redlich, Sami Sakari Rasanen, A. Tarazona Martinez, Lee Stuart Barnby, Jubin Mitra, Dominik Fehlker, Fiorella Fionda, Thomas Peitzmann, A. Nedosekin, Jerzy Gustaw Bartke, Linda Vickovic, Yonghong Zhang, M. Venaruzzo, O. Villalobos Baillie, Christian Lippmann, Edmundo Javier Garcia-Solis, Christoph Blume, Mikhail Malaev, Xiangrong Zhu, Bastian Bathen, K. Shtejer, E. Pereira De Oliveira Filho, Graham Richard Lee, Benjamin Andreas Hess, Monika Kofarago, Marian Ivanov, Jens Wiechula, Salvatore Aiola, B. K. Srivastava, Ramona Lea, Kyrre Skjerdal, Henrik Qvigstad, Xavier Bernard Lopez, Jaroslav Bielcik, Rune Langøy, Ana Maria Marin, Roberta Arnaldi, Sven Gotovac, T. E. Hilden, Satish Sharma, Elena Rogochaya, Chengxin Zhao, Enrico Fragiacomo, Markus Konrad Kohler, Teodor Siemiarczuk, Buddhadeb Bhattacharjee, Boris Wagner, D. L. D. Keijdener, Yifei Wang, A. Karasu Uysal, Andrzej Rybicki, Cvetan Valeriev Cheshkov, Radiy Ilkaev, Tyler Allen Browning, Henner Buesching, Mikhail Zhalov, Jan Fiete Grosse-Oetringhaus, Jan Wagner, G. D'Erasmo, R. de Rooij, P. I. Loenne, J. Thäder, M. Cherney, Vit Kucera, Ciprian Mihai Mitu, Silvia Arcelli, R. Romita, C. Søgaard, Raymond James Ehlers, P. H. S. Y. Jayarathna, Antonio Uras, G. Stefanek, Sidharth Kumar Prasad, Stefania Beole, Alexandre Alarcon Do Passo Suaide, J. W. Van Hoorne, Vladimir Nikulin, V. P. Kondratiev, T. Breitner, Andrey Vasiliev, Boris Batyunya, Arturo Alejandro Menchaca-Rocha, Leonardo Milano, David Dobrigkeit Chinellato, X. Sanchez Castro, Cristina Terrevoli, Gilda Scioli, Andreas Morsch, A. Palmeri, Uwe Westerhoff, Igor Altsybeev, A. Pesci, D. Eschweiler, J. G. Contreras, Shinichi Hayashi, Anton Andronic, Francesco Barile, Daniela Fabris, Heidrun E. K. Hartmann, Min Jung Kweon, J. L. Charvet, M. Sano, Xu Cai, Peter Chochula, S. L. La Pointe, Marek Bombara, Austin Vincent Harton, Rosi Reed, Maria Haiduc, Sergey Filchagin, Marco Bregant, D. P. Mahapatra, D. Domenicis Gimenez, J. Pluta, Evgeny Ryabinkin, Prabhat Ranjan Pujahari, Peter Strmen, Benjamin Donigus, Sumit Basu, Laure Marie Massacrier, Malgorzata Anna Janik, M. Kretz, Y. Sekiguchi, Enrico Scomparin, Jiri Mares, A. R. Reolon, Alexander Philipp Kalweit, Inayat Rasool Bhat, Vladimir Vechernin, Hyungtaik Jung, Alexander Mamonov, Fengchu Zhou, Jan Hladky, Muhammad Ajaz, G. Tejeda Muñoz, Thomas Michael Cormier, G. M. Innocenti, Marco Leoncino, Boris Hippolyte, Alexander Kluge, Redmer Alexander Bertens, David Olle Rickard Silvermyr, Barbara Guerzoni, Peter Christiansen, Helmut Oskar Oeschler, Se Yong Kim, J. W. Harris, Mauro Gallio, Laszlo Olah, Alla Maevskaya, M. I. Martínez, Deepa Thomas, Myunggeun Song, Lucia Leardini, Pradip Kumar Roy, I. E. Yushmanov, Michal Krelina, Baldo Sahlmuller, Eva Sicking, Joakim Nystrand, Eugenio Nappi, Stefania Bufalino, A. De Caro, J. Van Der Maarel, Yaroslav Berdnikov, P. Di Nezza, M. G. Munhoz, Giacomo Volpe, E. Montes, Ju Hwan Kang, Natasha Sharma, Paolo Camerini, R. Belmont, Sergey Voloshin, Diego Stocco, Y. Vinogradov, Jussi Samuli Viinikainen, Dmitry Finogeev, Subhash Singha, Zubayer Ahammed, N. Zaviyalov, A. Gomez Ramirez, E. Floratos, Kristjan Herlache Gulbrandsen, Udo Wolfgang Kebschull, Pascal Dupieux, Andrea Dainese, Sergey Fokin, Torsten Alt, Guy Paic, Pooja Pareek, Grazia Luparello, Mirko Planinic, Janet Elizabeth Seger, Andrea Francescon, Silvia Masciocchi, Dmitry Budnikov, Paraskevi Ganoti, E. Dénes, S. A. Ahn, Kamal Hussain Khan, Mikhail Ippolitov, Johannes Peter Wessels, M. Spacek, Tinku Sarkar Sinha, Andrei Ionut Herghelegiu, Heiko Engel, D. R. Gangadharan, Natalia Zhigareva, Igor Pshenichnov, Giacomo Vito Margagliotti, M. Vajzer, L. Valencia Palomo, Carlos Eugenio Perez Lara, C. Garabatos, Thanushan Kugathasan, C.J. Schmidt, Christophe Pierre Suire, H.R. Gulkanyan, M. van Leeuwen, Annika Passfeld, Alessandro Grelli, Anju Bhasin, R. Cruz Albino, Siegfried Valentin Foertsch, Johan Alme, Luciano Ramello, Mais Kazim Oglu Suleymanov, Kirill Voloshin, Subhasis Chattopadhyay, Anton Jusko, Laurent Ducroux, S. Schuchmann, Terry C Awes, Jeremy John Wilkinson, A. Vyushin, Theo Alexander Broker, Daicui Zhou, Despina Hatzifotiadou, A. W. Rauf, Aditya Nath Mishra, Alexandru Bercuci, Ivan Kralik, Pragati Sahoo, Suh-urk Chung, Cristiane Jahnke, Peter Zahariev Hristov, Jan Figiel, Beomsu Chang, Sk Noor Alam, Miroslav Pikna, Mario Sitta, Roberto Divia, Didier Alexandre, S. Porteboeuf-Houssais, A. Rachevski, G. A. Feofilov, A. Matyja, Kenta Shigaki, Janusz Oleniacz, Ana Vargas, Goran Simatovic, Danthasinghe Piyarathna, D. Watanabe, Jaime Norman, Jurgen Schukraft, Thomas Humanic, Yvonne Chiara Pachmayer, K. Das, Alessandro Feliciello, L. Cunqueiro, G.S. Shabratova, G. Santagati, A. De Falco, Ester Anna Rita Casula, D. Vranic, Vitaly Loginov, Dario Berzano, Jitendra Kumar, Davide Francesco Lodato, I. Maldonado Cervantes, Elena Bruna, Alexander Vinogradov, F. J. Sánchez Rodríguez, V. Razazi, M. Pachr, J. Anielski, A. C. Oliveira Da Silva, Nicola Bianchi, Rongrong Ma, Jovan Milosevic, Michelangelo Agnello, Catherine Micaela Silvestre, Maciej Pawel Szymanski, A. Tarantola Peloni, Michael Linus Knichel, M. Steinpreis, Giulio Usai, Dirk Hutter, Petr Zavada, M. Estienne, R. Dang, Yongwook Baek, Lidia Maria Gorlich, Bikash Sinha, Klaus Johannes Reygers, V. Lenti, Kenneth Francis Read, Jan Cepila, Peter Malzacher, B. Grinyov, Deepika Rathee, R. P. Scharenberg, Christina Markert, M. Rodríguez Cahuantzi, Paul Christoph Bätzing, G. Conesa Balbastre, Peter Martin Jacobs, Michal Sumbera, Chiara Zampolli, Victor Trubnikov, Rama Narayana Singaraju, Wladyslaw Henryk Trzaska, N. Grion, Satoshi Yano, Yury Ryabov, M. Wilde, Jon Christopher Wikne, Carlos A. Salgado, Madalina-Gabriela Tarzila, Angelo Rivetti, P. Vande Vyvre, Huaqiao Zhang, Christophe Furget, C. Bedda, Ante Bilandzic, Sonia Parmar, Jean Willy Andre Cleymans, Volker Lindenstruth, Francesca Soramel, Michal Petran, P. L. M. Podesta-Lerma, Ramni Gupta, Vladimir Belyaev, Satyajit Jena, Daniel Berenyi, Predrag Buncic, Laszlo Boldizsar, Renaud Vernet, Anders Garritt Knospe, C. Klein-Bösing, Maxime Guilbaud, Ulrich Fuchs, Corrado Gargiulo, S. Kox, Podist Kurashvili, Dae Sung Hwang, Y. P. Viyogi, Alberto Baldisseri, Maciej Slupecki, G. Puddu, Mikolaj Krzewicki, Patrick Simon Reichelt, Sergey Nazarenko, J. Mercado Pérez, P. La Rocca, Alexander Akindinov, Markus Fasel, Alberto Caliva, M. Botje, Paola Gianotti, D. Evans, Paolo Martinengo, Alexey Kurepin, Ionel Stan, Ajay Kumar Dash, Massimiliano Marchisone, Vito Manzari, Kai Oliver Schweda, Levente Molnar, Alessandro Ferretti, D. De Gruttola, V. Wagner, Anthony Robert Timmins, Vojtech Petracek, Viktor Riabov, Palash Khan, Julien Faivre, Betty Abelev, Jeewon Seo, Y. Miake, K. Šafařík, Maria Vasileiou, Raffaele Grosso, Adam Ryszard Kisiel, Davide Caffarri, A. Ortiz Velasquez, S. Böttger, Mihai Petrovici, Stefano Bagnasco, Indranil Das, Ranbir Singh, E. Stenlund, Paulus Gerardus Kuijer, Kishora Nayak, Pietro Cortese, Johannes Hendrik Stiller, Ara Grigoryan, Riccardo Russo, Costin Grigoras, Barbara Ewa Erazmus, Maria Nicassio, Brigitte Cheynis, T. J. M. Symons, Jaroslav Adam, Meidana Huang, Kilian Eberhard Schwarz, Renato Angelo Ricci, Zabulon Vilakazi, Bernd Stefan Windelband, Yury Pestov, Mihaela Gheata, A. Szczepankiewicz, Marton Vargyas, Néstor Armesto, Federico Ronchetti, Giuseppe Viesti, Andre Mischke, Andrea Dubla, Ivan Vorobyev, Emilia Leogrande, Mohd Danish Azmi, A. Jacholkowski, V. Paticchio, Vladimir Kovalenko, Andrei Gheata, R. Varma, Shiming Yang, C. Bianchin, Ilaria Aimo, D. I. Patalakha, M. Esposito, D. J. Kim, Hideki Hamagaki, Ralf Peter Averbeck, C. Lagana Fernandes, Nikola Poljak, Alberica Toia, Premomoy Ghosh, I. Cortés Maldonado, Konstantin Mikhaylov, B. von Haller, Magnus Mager, Stefan Thomas Heckel, Shuaib Ahmad Khan, A. B. Kurepin, Luke David Hanratty, Pietro Antonioli, Luisa Cifarelli, Bedangadas Mohanty, A. Rodriguez Manso, Michael Andreas Winn, Iwona Anna Sputowska, Nur Hussain, A. Di Mauro, E. G. Ferreiro, Adrian Sevcenco, G.F. Segato, Peter Braun-Munzinger, Sanjeev Singh Sambyal, F. V. Böhmer, G. de Cataldo, Marcel Araujo Silva Figueredo, Naghmeh Mohammadi, C. E. Pérez Lara, Alexander Borissov, M. Veldhoen, Alessandra Fantoni, Philippe Rosnet, Nirbhay Kumar Behera, Angela Badala, V. R. Loggins, Ralf Keidel, Panagiotis Christakoglou, Attiq Ur Rehman, H. Caines, Motoi Inaba, S. Rohni, Alice Zimmermann, Felix Reidt, S. Vergara Limón, G. Koyithatta Meethaleveedu, Philipp Johannes Luettig, Anand Kumar Dubey, Hans Martin Ljunggren, Olja Dordic, A. K. Bhati, Tim Schuster, C. Ceballos Sanchez, V. Chibante Barroso, Raghunath Sahoo, E. Calvo Villar, Stefan Kirsch, Y. Zoccarato, Valerie Ramillien Barret, T. Aronsson, Dmitry Mal'kevich, Oleg Karavichev, S. De Pasquale, L. Montaño Zetina, Hanna Paulina Zbroszczyk, M. A. Diaz Corchero, C. Ionita, V. Grigoriev, Toru Sugitate, Michele Floris, Ijaz Ahmed, Nikolai Smirnov, Domenico Elia, Y. Corrales Morales, Raphael Noel Tieulent, Jacobus Onderwaater, Gergoe Hamar, S. Di Liberto, Toralf Bernhard Skaali, Laurent Bernard Aphecetche, Chiara Oppedisano, Junjie Zhu, G. Martínez García, Herve Borel, Tatsuya Chujo, Sibaji Raha, P. González-Zamora, Sedat Altinpinar, T. K. Nayak, Sara Vallero, Sudipan De, Bruno Alessandro, Sudhir Raniwala, Tatiana Karavicheva, Sandro Bjelogrlic, Subikash Choudhury, Alberto Collu, Ionut Christian Arsene, B. Polichtchouk, Massimo Masera, ShinIchi Esumi, Federico Antinori, F. Blanco, Biswarup Paul, A. Batista Camejo, Saehanseul Oh, Alexander Szabo, Filip Krizek, D. Pant, Paolo Pagano, Gerardus Nooren, Jan Musinsky, Branislav Sitar, B. V.K.S. Potukuchi, Ruben Shahoyan, D. Falchieri, Janka Vrlakova, Catia Petta, Ombretta Pinazza, Arild Velure, Kjetil Ullaland, N. De Marco, E. Belmont-Moreno, Francesco Riggi, Panagiota Foka, Mesut Arslandok, Peter Kalinak, Valery Punin, Andrea Agostinelli, Tome Anticic, Marta Verweij, S.A. Zaporozhets, Adriana Telesca, M. Berger, Antonin Maire, Werner Riegler, Franco Meddi, Dmitry Aleksandrov, Franck Manso, Chinorat Kobdaj, Hege Austrheim Erdal, Z. Conesa del Valle, I. Kulakov, Francesco Bossu, Michal Meres, Tiziano Virgili, Jennifer Lynn Klay, Taku Gunji, J. S. Real, M. C. S. Williams, Arturo Tauro, Francesco Prino, Anton Alkin, H. Delagrange, T. Dobrowolski, Alex Hansen, Eugen Mudnic, Jorn Henning Putschke, Martijn Reicher, J. Castillo Castellanos, Mihai Niculescu, Y. Sibiriak, S.A. Sadovsky, E. Spiriti, Francesco Carena, Christian Claude Kuhn, Elena Rocco, B. S. Nilsen, H. Appelshäuser, Ketil Røed, P. Cerello, Evgeny Kryshen, M. A. Tangaro, Roberto Preghenella, Marek Chojnacki, I. Ilkiv, E. Serradilla, Sergey Nikolaev, Eugenio Scapparone, Mikhail Stolpovskiy, Sean Murray, Peter Levai, R. Bellwied, E. H.O. Pohjoisaho, Gergely Gabor Barnafoldi, P. K. Sahu, Hans Muller, Sergey Nikulin, Y. Kucheriaev, Alexis Jean-Michel Mas, Evgeny Karpechev, and J. Martin Blanco
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, 010308 nuclear & particles physics, Scattering, Binary number, 01 natural sciences, Uncorrelated, Nuclear physics, Correlation, Pseudorapidity, 0103 physical sciences, High Energy Physics::Experiment, Multiplicity (chemistry), Nuclear Experiment, 010306 general physics, Glauber
Abstract: Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7
Published: 2015
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39. A comparison of the outcome using Ligasure™ small jaw and clamp-and-tie technique in thyroidectomy: a randomized single center study

Author: Fabrizio Maria Frattaroli, J. M. Frattaroli, Giuseppe Pappalardo, F. De Lucia, F. Fabi, Saverio Coiro, and Elena Manna
Subjects: Adult, Male, medicine.medical_specialty, Hypoparathyroidism, medicine.medical_treatment, Operative Time, Blood Loss, Surgical, Postoperative Hemorrhage, Hyperthyroidism, Risk Assessment, Postoperative Complications, Paralysis, medicine, Recurrent laryngeal nerve, Humans, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, business.industry, Thyroidectomy, Recovery of Function, Middle Aged, Surgical Instruments, medicine.disease, Hemostasis, Surgical, Cardiac surgery, Surgery, Patient Outcome Assessment, Treatment Outcome, Cardiothoracic surgery, Anesthesia, Recurrent Laryngeal Nerve Injuries, Female, medicine.symptom, business, Follow-Up Studies, Abdominal surgery
Abstract: Hypoparathyroidism and paralysis of the recurrent laryngeal nerve (RLN) still remain the most frequent specific complications of thyroid surgery. This study evaluates the effects of employment of a recently introduced device (LigaSure™ Small Jaw, LSJ), compared to the traditional clamp-and-tie (CT) technique, on the short- and long-term outcome of the patients who underwent thyroidectomy. This prospective, randomized study included 190 patients enrolled from October 2011 to July 2013. The numbers of patients in the LSJ group and the CT group were both 95. We studied the following: operative times, intraoperative and postoperative blood losses, intact parathormone (iPTH) and calcium serum levels, and the incidence of RLN paralysis. The two cohorts were homogeneous for age, sex, surgical indication, BMI, ASA score, and estimated thyroid volume. Operation time has been 73.90 ± 23.35 min in group CT and 60.20 ± 22.36 min in group LSJ (p = 0.002). Intraoperative blood losses have been 47 ± 18 ml in group CT and 38 ± 14 in group LSJ (p = 0.002), while postoperative blood losses have been 45 ± 21 ml in group CT and 40 ± 20 in group LSJ (p = 0.105). The mean calcium blood level in group CT has been 8.12, 7.79, and 7.92 mg/dl in the first, second, and third postoperative days, respectively, as well as 8.26, 7.97, and 8.22 mg/dl for group LSJ (p > 0.05). Basal and post-thyroidectomy iPTH levels have been 46.49 and 23.64 pg/ml in group CT (Δ = 49.15 %), as well as 51.06 and 27.73 (Δ = 45.69 %) in group LSJ (p > 0.05). Permanent RLN paralysis was 1.05 % in LSJ group and 0 % in CT group. The employment of LSJ reduces in a statistically significant way both operative times and intraoperative blood losses. No significant differences were found as far as postoperative RLN paralysis and hypoparathyroidism.
Published: 2015
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40. On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides

Author: Giuseppe Pappalardo, Alessandro Sinopoli, and Marianna Flora Tomasello
Subjects: endocrine system, Amyloid, Protein Conformation, Amyloid beta, Cytotoxicity, Endocrinology, Diabetes and Metabolism, Peptide, Review Article, Fibril, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Aggregation, Islets of Langerhans, Endocrinology, Protein structure, IAPP, medicine, Humans, Glucose homeostasis, chemistry.chemical_classification, lcsh:RC648-665, biology, Pancreatic islets, Amyloidosis, medicine.disease, Peptide Fragments, Type 2 Diabetes, Islet Amyloid Polypeptide, medicine.anatomical_structure, Diabetes Mellitus, Type 2, Biochemistry, chemistry, biology.protein
Abstract: Pancreatic islets in type 2 diabetesmellitus (T2DM) patients are characterized by reduced ?-cells mass, increased ?-cells apoptosis, and diffuse extracellular amyloidosis.Amyloid deposition involves the aggregation of the islet amyloid polypeptide (IAPP) which is a neuropancreatic hormone cosecreted with insulin by ?-cells. IAPP is physiologically involved in glucose homeostasis, but it may turn toxic to ?-cells owing to its tendency to misfold giving rise to oligomers and amyloid fibrils. Despitemany studies dealing with this issue, the process by which the natively unfolded IAPP starts to self-assemble and the overall factors promoting this conversion are still poorly understood. The process of IAPP aggregation in vivo is harmful to pancreatic ?-cells but the nature of the IAPP toxic species, what exactly causes ?-cell damage and how ?-cells die, remains elusive. Over the last decades, there has been growing consensus about the notion that early stage molecular assemblies, notably small hIAPP oligomers, are the culprit of ?-cells decline. Some studies have pointed out how numerous environmental factors might affect "in vivo" the conformational features, as well as the aggregation and the cytotoxic properties of IAPP. Herein we review recent progress in the field, focusing our attention on the influences that membranes, pH, and metal ions may have on the conformational conversion and cytotoxicity of full-length IAPP as well as some peptide fragments. Thereafter, current theories proposed for the mechanisms of toxicity will be also summarized together with an outline of the underlying molecular links between IAPP and amyloid beta (A?) misfolding.
Published: 2015
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41. Measurement of electrons from beauty-hadron decays in p-Pb collisions at s N N = 5.02 $$ \sqrt{s_{\mathrm{NN}}}=5.02 $$ TeV and Pb-Pb collisions at s N N = 2.76 $$ \sqrt{s_{\mathrm{NN}}}=2.76 $$ TeV

Author: Christophe Pierre Suire, Vladimir Belyaev, Jai Samuel Nielsen Salzwedel, Supriya Das, Artur Furs, Vladislav Manko, Bogdan Vulpescu, Alla Maevskaya, Grigorii Feofilov, Nachiketa Sarkar, Vladimir Peskov, Dae-Hyeok Kim, Oleg Karavichev, Livio Bianchi, Benjamin Audurier, Mirko Planinic, Federico Cindolo, Ian Gardner Bearden, Lee Stuart Barnby, L. Šándor, Anatoly Tikhonov, Tatsuya Chujo, Kirill Voloshin, Roy Crawford Lemmon, B. Erazmus, Andrea Festanti, Jun Takahashi, Silvia Arcelli, Dmitry Budnikov, Alberto Martin Gago Medina, Victor Jose Gaston Feuillard, Vladimir Ivanov, Jana Bielcikova, Alexey Kuryakin, Filimon Roukoutakis, Audrey Francisco, Andry Malala Rakotozafindrabe, Eugen Mudnic, Oleksandr Kovalenko, Francesca Carnesecchi, Marian Krivda, Igor Pshenichnov, Gideon Francois Steyn, M. Mohisin Khan, I. Das, I. Berceanu, Borge Svane Nielsen, Piero Giubilato, Tuva Ora Herenui Richert, Markus Bernhard Zimmermann, Robert Vertesi, Dariusz Czeslaw Miskowiec, Jorn Henning Putschke, Enrichetta Maria Fiore, Bjarte Kileng, Camilo Ernesto Lara Martinez, Xavier Bernard Lopez, Jaroslav Bielcik, Jan Figiel, Jacek Tomasz Otwinowski, M. R. Cosentino, Grzegorz Andrzej Wilk, Jamila Bashir Butt, Rama Chandra Baral, M. Fasel, Matthias Richter, Franco Meddi, Dmitry Aleksandrov, Raphaelle Marie Bailhache, Franck Manso, Jovan Milosevic, Klaus Barth, Chinorat Kobdaj, Elena Rogochaya, Enrico Fragiacomo, Peter Graham Jones, Henrique Jose Correia Zanoli, Massimiliano Marchisone, Paolo Camerini, Deepa Thomas, Sergey Voloshin, Artem Shangaraev, M. Estienne, Andrey Reshetin, Mikhail Malaev, Mihaela Gheata, Gustavo Conesa Balbastre, Sagarika Swain, Sudipan De, Theo Alexander Broker, Despina Hatzifotiadou, Harald Appelshaeuser, A. Rachevski, Smbat Grigoryan, Rainer Martin Schicker, Giuseppe Trombetta, Peter Martin Jacobs, Jon Christopher Wikne, Alessandro De Falco, Charles E. Hughes, Ramni Gupta, Predrag Buncic, Anders Garritt Knospe, Laszlo Boldizsar, Paola Gianotti, Elisa Meninno, Annelies Marianne Veen, Vito Manzari, Jasper Van Der Maarel, Arvind Khuntia, Viktor Riabov, Lawrence Pinsky, Christian Claude Kuhn, Ewa Gladysz-dziadus, Jan Rak, Dong Jo Kim, Susanta Kumar Pal, W. Park, Alberto Baldisseri, Sukalyan Chattopadhyay, Marcello Lunardon, Matej Oravec, Rahul Ramachandran Nair, Mohamad Tarhini, Andres Gomez Ramirez, Alberica Toia, Sebastian Lehner, P. Cerello, Ernesto Calvo Villar, Andrzej Deloff, Magnus Mager, J. Book, Chaosong Gao, Saikat Biswas, Jacopo Margutti, Sergey Nikolaev, Peter Zahariev Hristov, Pietro Antonioli, Rachid Guernane, Luisa Cifarelli, Andre Augustinus, Mikhail Zhalov, Evert Anders Stenlund, Anton Andronic, Francesco Bossu, Prakhar Garg, Anastasia Maria Barbano, Andreas Morsch, Rishat Sultanov, Giuseppe Pappalardo, Ermanno Vercellin, Richard Daniel Majka, Minjung Kim, Eugenio Scapparone, Shingo Sakai, Andrea Alici, Francesco Noferini, Rajendra Nath Patra, Serpil Yalcin, Amalia Pop, Martin Poghosyan, A. R. Reolon, Matteo Lupi, Nikolay Zavyalov, Artem Konevskikh, Tahir Hussain, Debojit Sarkar, Sylvain Chapeland, Volodymyr Chelnokov, Adela Kravcakova, Guido Alexander Willems, Javier Ernesto Castillo Castellanos, Kunal Garg, Michal Meres, Tiziano Virgili, Yves Roland Schutz, Uwe Westerhoff, Federica Sozzi, J. W. Harris, Pietro Cortese, Mauro Gallio, Paola La Rocca, Edmundo Javier Garcia-Solis, Ranjit Nayak, Bastian Bathen, Henrik Qvigstad, Chitrasen Jena, Imrich Szarka, Nicole Bastid, Barbara Jacak, Alexander Philipp Kalweit, Sona Pochybova, Anatoly Kolozhvari, Claudiu Cornel Schiaua, Mengliang Wang, Esther Montes Prado, Peter Glassel, Alexander Borissov, Baldo Sahlmuller, Michal Kopcik, Orlando Villalobos Baillie, Jan Fiete Grosse-Oetringhaus, Igor Altsybeev, Davide Pagano, Jiri Mares, Xiaoming Zhang, Cristian Andrei, Venelin Anguelov, Eliane Epple, Taesoo Kim, Camila De Conti, Sandra Moretto, Andrea Danu, Alexander Kurepin, Alexander Kluge, Redmer Alexander Bertens, Maximiliano Puccio, Raimond Snellings, Federico Antinori, Rinaldo Rui, Qiye Shou, Sergey Evdokimov, Dmitry Yurevich Peresunko, Rafael Derradi De Souza, Tribeni Mishra, Jesus Guillermo Contreras Nuno, Laszlo Olah, Udo Wolfgang Kebschull, Pascal Dupieux, Andrea Dainese, Sergey Fokin, Torsten Alt, Sergey Sadovskiy, Ankhi Roy, Arianna Batista Camejo, Mahmut Ozdemir, Christian Bourjau, Silvia Masciocchi, Sun Kun Oh, Gerardus Nooren, Jan Musinsky, Ombretta Pinazza, Hiroki Yokoyama, Francesco Barile, Daniela Fabris, Irais Bautista Guzman, M. Ivanov, Sandro Bjelogrlic, Robert Helmut Munzer, Renato Aparecido Negrao De Oliveira, Marie Germain, Jean-Luc Fernand Charvet, Latchezar Betev, Alexey Bogdanov, Yaroslav Berdnikov, Michal Broz, Somnath Kar, Ulrich Michael Frankenfeld, Sebastian Rosado Navarro, Anik Gupta, Zubayer Ahammed, Alberto Collu, Samrangy Sadhu, Jana Crkovská, Benedetto Di Ruzza, Cristina Bedda, Katie Leanne Graham, Gabor Biro, Naghmeh Mohammadi, Thorsten Sven Kollegger, Johann Zmeskal, Lucile Ronflette, Eulogio Serradilla Rodriguez, Domenico Colella, Mona Sharma, Vladislav Grigoryev, Sergio Arturo Iga Buitron, Wladyslaw Henryk Trzaska, Madalina-Gabriela Tarzila, Laura Fabbietti, Satyajit Jena, Kenta Shigaki, Hongbo Zhu, Ayben Karasu Uysal, Alice Elisabeth Ohlson, Zuman Zhang, Greeshma Koyithatta Meethaleveedu, Sergey Kiselev, Yury Kharlov, Carlos Duarte Galvan, Naoto Tanaka, Manuel Colocci, Buddhadeb Bhattacharjee, Martin Andreas Volkl, Vladimir Samsonov, Sven Gotovac, Zabulon Vilakazi, Marcello Borri, Tinku Sarkar Sinha, Ivan Vorobyev, Alessandra Lattuca, Jochen Klein, Adam Tomasz Matyja, Giacomo Vito Margagliotti, Luciano Musa, Giuseppe Bruno, Nicole Alice Martin, Renaud Vernet, Kyungeon Choi, Anders Nils Erik Oskarsson, Maurizio Basile, Boris Wagner, Slavka Jadlovska, Guillaume Batigne, Trine Spedstad Tveter, Gianluca Aglieri Rinella, Ivan Kisel, Chiara Bianchin, Ajay Kumar Dash, Tyler Allen Browning, Jose Ruben Alfaro Molina, Joakim Nystrand, Hendrik Poppenborg, Sebastian Klewin, Christine Nattrass, Ketil Roeed, Paulus Gerardus Kuijer, Yasser Corrales Morales, Alexander Vodopyanov, Marco H. D. van Leeuwen, Alessandro Grelli, Ajay Kumar, Stefan Kirsch, Sergey Nikulin, Siegfried Valentin Foertsch, Anjali Sharma, Xiaomei Li, Alexandr Tumkin, Johan Alme, Giulio Eulisse, Kishora Nayak, D. Alexandre, Evgeny Karpechev, Kilian Eberhard Schwarz, Lucina Gabriela Espinoza Beltran, Florian Herrmann, P. Pillot, Shinichi Hayashi, Valerii Kondratev, Suh-urk Chung, Sandun Pahula Hewage, Tome Anticic, Luciano Ramello, Piotr Jan Gasik, Daicui Zhou, Vikas Singhal, Antonino Zichichi, M. Spyropoulou-Stassinaki, Marcelo Gameiro Munhoz, Valeria Muccifora, Subhasis Chattopadhyay, Markus Keil, Saehanseul Oh, Marcel Araujo Silva Figueredo, Dario Berzano, Ken Oyama, Anju Bhasin, Vladimir Izucheev, Jeremy John Wilkinson, Daiki Sekihata, Sumit Basu, Petr Zavada, Nora De Marco, M. Kim, Gines Martinez-Garcia, Gabriele Gaetano Fronze, Rosario Turrisi, Arturo Alejandro Menchaca-Rocha, Marek Bombara, Ernst Hellbar, Peter Kalinak, Leonid Vinogradov, Gabor Kiss, Valery Punin, Evgeny Kondratyuk, S.A. Zaporozhets, Marianna Mazzilli, Adriana Telesca, Julien Charles Hamon, Vladimir Kaplin, Caterina Deplano, Paolo Giubellino, Vytautas Vislavicius, Marc Weber, Oksana Shadura, Marek Kowalski, Pierre Vande Vyvre, Philippe Crochet, Johanna Stachel, Katarina Krizkova Gajdosova, Krzysztof Redlich, Dieter Roehrich, Muhammad Umair Naru, Deepika Rathee, Christina Markert, Paul Christoph Bätzing, Jaime Norman, Alessandra Fantoni, Sushanta Tripathy, Angela Badala, Sami Sakari Rasanen, Ashutosh Pandey, Jubin Mitra, Panagiotis Christakoglou, Friederike Bock, M. A. Lisa, Gyula Bencedi, Bharati Naik, Janusz Oleniacz, Boris Polishchuk, Volodymyr Yurchenko, Antonija Utrobicic, Renu Bala, Sanjib Muhuri, Danthasinghe Piyarathna, Ionel Stan, Levente Molnar, Zixuan Song, Ante Bilandzic, Elena Bruna, Sang Un Ahn, Valentina Zaccolo, Pedro Luis Manuel Podesta Lerma, Hikari Murakami, Jørgen André Lien, Nicola Bianchi, Ionut Cristian Arsene, Paul Stankus, Ester Anna Rita Casula, Arturo Tauro, Soyeon Cho, Prabhat Ranjan Pujahari, Peter Strmen, Chengxin Zhao, Christoph Blume, Alexander Szabo, Filip Krizek, B. Grynyov, Zhuo Zhou, Stefano Piano, Branislav Sitar, Sourav Kundu, Barthelemy von Haller, Julius Maximilian Gronefeld, Sarah Julie Porteboeuf, Jitendra Kumar, Davide Francesco Lodato, Meike Charlotte Danisch, Catia Petta, Sidharth Kumar Prasad, Arild Velure, Felix Reidt, Kjetil Ullaland, Youngil Kwon, Grazia Luparello, Vladimir Vechernin, Christian Klein-Boesing, Hartmut Hillemanns, Hans Rudolf Schmidt, Maciej Pawel Szymanski, Salvatore De Pasquale, Teodor Siemiarczuk, Raghunath Sahoo, Valerie Ramillien Barret, Antonio Ortiz Velasquez, Yury Ryabov, Ernesto Belmont Moreno, Mikolaj Krzewicki, Raffaele Grosso, Klaus Johannes Reygers, Astrid Morreale, Miljenko Suljic, Dominik Voscek, Ali Okatan, Christoph Mayer, Pranjal Sarma, Bruno Espagnon, Miguel Martinez Pedreira, Oeystein Djuvsland, Cvetan Valeriev Cheshkov, Ildefonso Leon Monzon, Radiy Ilkaev, Fouad Rami, Boris Batyunya, Mario Ivan Martinez Hernandez, Serhiy Senyukov, Fabian Ng, Gerardo Antonio Herrera Corral, G. Volpe, Maitreyee Mukherjee, Elisa Incani, Yasuo Miake, Madan M. Aggarwal, Jonghan Park, Philipp Johannes Luettig, Yuri Melikyan, Olja Dordic, Pascal Dillenseger, Vojtech Petracek, Neelima Agrawal, Corrado Cicalo, Palash Khan, Davide Caffarri, Maciej Slupecki, Jens Joergen Gaardhoeje, G. Puddu, Jiyoung Kim, Crispin Williams, Yosuke Watanabe, N. Grion, M. Sano, Xu Cai, S. Mahajan, Andrzej Rybicki, Monika Sharma, D. Domenicis Gimenez, J. Pluta, Vit Kucera, Shyam Kumar, Ciprian Mihai Mitu, Evgeny Ryabinkin, Yongwook Baek, Stefano Bagnasco, Johannes Hendrik Stiller, James Declan Mulligan, Andrey Zarochentsev, Christophe Furget, Hanna Paulina Zbroszczyk, Hyungtaik Jung, Pasquale Di Nezza, Benjamin Andreas Hess, Jaroslav Adam, Se Yong Kim, Shuaib Ahmad Khan, Igor Lakomov, Antoine Xavier Lardeux, Jerzy Gustaw Bartke, Liudmila Malinina, Prabhakar Palni, Francesco Riggi, Toru Sugitate, Panagiota Foka, Jean Willy Andre Cleymans, Volker Lindenstruth, Francesca Soramel, Alexis Jean-michel Mas, Mesut Arslandok, Yury Pestov, Caio Lagana Fernandes, Kai Oliver Schweda, Wisla Carena, Martino Gagliardi, O. A. Grachov, Michele Floris, Benjamin Donigus, Anand Kumar Dubey, Nirbhay Kumar Behera, Justin Thomas Blair, Michal Sefcik, Yajun Mao, Marton Vargyas, Antonio Di Mauro, Andre Mischke, Leticia Cunqueiro Mendez, Hugo Denis Antonio Pereira Da Costa, Eleazar Cuautle Flores, Hans Martin Ljunggren, D. Di Bari, Vardanush Papikyan, R. Scott, Jussi Samuli Viinikainen, Dmitry Finogeev, Preeti Dhankher, Ilya Selyuzhenkov, Dennis Franz Weiser, Werner Riegler, Bogdan Theodor Rascanu, Jongsik Eum, M. E. Connors, Rene Bellwied, Ganesh Jagannath Tambave, Ramona Lea, Marielle Chartier, Gyulnara Eyyubova, H. Zhang, Hermes Leon Vargas, Pradip Kumar Sahu, Eugenio Nappi, Kristjan Herlache Gulbrandsen, Charalampos Kouzinopoulos, Johannes Peter Wessels, Sampo Saarinen, Jacobus Onderwaater, Rosario Nania, Annika Passfeld, Dagmar Adamová, Eleuterio Spiriti, Alberto Caliva, Helmut Oskar Oeschler, Miguel Angel Diaz Corchero, Maria Nicassio, Dezso Varga, Andrew John Lowe, Alexandre Alarcon Do Passo Suaide, Henner Buesching, Erik Brücken, A. Nedosekin, Xinye Peng, Esther Bartsch, Linda Vickovic, Nicolo Jacazio, Yonghong Zhang, Pedro Gonzalez Zamora, Jihye Song, M. Irfan, Alex Henri Jean Chauvin, D. De Gruttola, Jennifer Lynn Klay, Victor Gonzalez, Andrew John Castro, Christian Lippmann, Taku Gunji, David H. Evans, Antonio Carlos Oliveira da Silva, Monika Joanna Jakubowska, Goran Simatovic, Wanchaloem Poonsawat, Chiara Oppedisano, Austin Vincent Harton, Francesco Prino, Mohammad Ahmad Saleh, Evgeny Kryshen, Giulio Usai, Dirk Hutter, Mohammad Tariq, Oliver Busch, David Dobrigkeit Chinellato, F. Ronchetti, Ismael Cortes Maldonado, Anton Alkin, V. Petrov, Lukas Nellen, David Olle Rickard Silvermyr, Andrea Dubla, Lais Ozelin De Lima Pimentel, Junjie Zhu, Edgar Perez Lezama, Arturo Fernandez Tellez, Sergio Vergara Limon, Hector Bello Martinez, Domenico Elia, Sorin Ion Zgura, Gergoe Hamar, Martin Schmidt, Barbara Guerzoni, Ankita Sharma, Peter Christiansen, Sergey Filchagin, Marco Bregant, Mihai Petrovici, Ara Grigoryan, R. Varma, Jorge Mercado-perez, Diego Stocco, Paolo Bartalini, Andrey Vasiliev, Sibaji Raha, Filip Erhardt, Bernd Stefan Windelband, In-kwon Yoo, Raul Tonatiuh Jimenez Bustamante, Varlen Grabski, Chiara Zampolli, Enrico Scomparin, Edith Zinhle Buthelezi, Sibaliso Mhlanga, Mais Kazim Oglu Suleymanov, Laurent Ducroux, Pragati Sahoo, Sk Noor Alam, Paul Alois Buhler, Vladimir V. Isakov, C. Ceballos Sanchez, Jan Pospíšil, Emilia Leogrande, Viktor Ratza, Mihai Niculescu, Alexander Vinogradov, Catherine Micaela Silvestre, Steffen Georg Weber, Giuseppe Simonetti, Roberto Preghenella, Pedro Hugo Ferreira Natal Da Luz, Hongkai Wang, Marek Chojnacki, Jan de Cuveland, Natasha Sharma, Mikhail Ippolitov, Massimo Masera, Dmitry Mal'kevich, ShinIchi Esumi, Mario Fusco Girard, J. Cerkala, Alexandru Bercuci, Hyeonjoong Kim, Ivan Ravasenga, Juan Carlos Cabanillas Noris, Pooja Pareek, Darius Keijdener, Francesco Carena, Ernesto Lopez Torres, Natalia Zhigareva, Biswarup Paul, Cynthia Marie Hadjidakis, Nima Zardoshti, Ju Hwan Kang, Janet Elizabeth Seger, Andrea Francescon, Natalia Kondratyeva, Jeremi Niedziela, Mateusz Andrzej Ploskon, Ralf Peter Averbeck, Jacobus Willem Van Hoorne, Paolo Pagano, Alessandra Maria Mazzoni, Shu Li, Sonia Rajput, Astrid Vauthier, Filippo Costa, Lukas Gruber, Ruben Shahoyan, David Michael Rohr, Rudiger Haake, Stefano Trogolo, Michael Linus Knichel, Patrick Simon Reichelt, Sergey Nazarenko, Kohei Terasaki, Janka Vrlakova, Karel Safarik, Tomoya Tsuji, Arseniy Shabanov, Jogender Saini, Myunggeun Song, Christian Schmidt, Ritsuya Hosokawa, Tyler Harrison Lutz, Fedor Guber, A. Szczepankiewicz, Vasco Miguel Chibante Barroso, Brigitte Cheynis, Min Jung Kweon, Michael Henry Oliver, Laurent Bernard Aphecetche, Constantinos Loizides, Alexander Akindinov, Suharyo Sumowidagdo, Monika Kofarago, Jens Wiechula, Salvatore Aiola, Raymond James Ehlers, Lucia Leardini, D. Watanabe, Thomas Humanic, Uzma Tabassam, Carsten Klein, Herve Borel, Soren Pontoppidan Sorensen, Jochen Mathias Thaeder, Jurgen Schukraft, Vladimir Nikulin, Maria Haiduc, Boris Hippolyte, Per-Ivar Lønne, Michael Andreas Winn, Jinsook Kim, Tomas Wilhelm Snellman, Jinjin Pan, A. K. Bhati, Nikolai Smirnov, Jihyun Bhom, Hideki Hamagaki, Ken Suzuki, Bruno Alessandro, Victor Trubnikov, Rama Narayana Singaraju, Jan Cabala, Anselmo Margotti, H. Caines, Sudhir Raniwala, S. Balasubramanian, Raphael Noel Tieulent, Sedat Altinpinar, T. K. Nayak, Julien Faivre, Tatiana Karavicheva, Jose Garabatos Cuadrado, Fabio Filippo Colamaria, Subikash Choudhury, Denise Aparecida Moreira De Godoy, Xiaowen Ren, Annalisa Mastroserio, Debasish Das, Antonio Uras, Stefania Beole, Mario Rodriguez Cahuantzi, Andile Mothegi Whitehead, Ali Zaman, Haavard Helstrup, Ranbir Singh, Mandeep Kour, Oton Vazquez Doce, Rainer Arno Ernst Renfordt, Andrew Michael Kubera, Danilo Silva De Albuquerque, Petr Nomokonov, Giacinto de Cataldo, Hans Peter Beck, David Horak, Rashmi Raniwala, Tsubasa Okubo, Sonia Parmar, Oliver Werner Arnold, Inayat Rasool Bhat, Marco Marquard, Krzysztof Marek Sielewicz, Malgorzata Anna Janik, Iouri Belikov, Thomas Dietel, Claude Andre Pruneau, Boris Teyssier, Do-Won Kim, Roberto Barbera, Elena Botta, Maria Vasileiou, Zhongbao Yin, Roman Lietava, V. Paticchio, Vladimir Kovalenko, Elisa Laudi, Shakeel Ahmad, You Zhou, R Jefferson Porter, Fernando Scarlassara, Ana Maria Marin, Sohail Musa Mahmood, Aurora Diozcora Vargas Trevino, Peter Braun-Munzinger, Sanjeev Singh Sambyal, Luis Alberto Perez Moreno, Caio Alves Garcia Prado, Ashik Ikbal Sheikh, Philippe Rosnet, Ralf Keidel, Konstantin Munning, Alice Zimmermann, Lilit Karayan, Gennady Zinovjev, Sadhana Dash, Paraskevi Ganoti, Peter Levai, Cristiane Jahnke, Beomsu Chang, Tatiana Drozhzhova, Catalin-Lucian Ristea, Gergely Gabor Barnafoldi, D. Vranic, Vitaly Loginov, Lidia Maria Gorlich, Kenneth Francis Read, Zaida Conesa del Valle, Jan Cepila, Stefania Bufalino, Podist Kurashvili, Dae Sung Hwang, Daniel Michael Muhlheim, Sabyasachi Siddhanta, Alberto Masoni, Fiorella Fionda, Harry Arthur Andrews, Thomas Peitzmann, Seongjoo Lee, M. Cherney, Matti Mikael Mieskolainen, Thomas Michael Cormier, V. Lenti, Lokesh Kumar, Marco Leoncino, Hua Pei, Ulrich Fuchs, Corrado Gargiulo, Manoj Bhanudas Jadhav, Tomas Vanat, Annalisa De Caro, Guy Paic, Yury Sibiryak, Erin Frances Gauger, Premomoy Ghosh, Konstantin Mikhaylov, Kirill Lapidus, Anisa Khatun, Iwona Anna Sputowska, Nur Hussain, Jesse Thomas Buxton, Aditya Nath Mishra, Roberto Divia, Sarita Sahoo, Yvonne Chiara Pachmayer, Alessandro Feliciello, Katherin Shtejer Diaz, Johannes Lehrbach, Mohd Danish Azmi, A. Maire, Anton Jusko, Ivan Kralik, Peter Malzacher, R. Orava, Miroslav Pikna, Mario Sitta, Attiq Ur Rehman, Motoi Inaba, Jin Hee Yoon, Dmitry Blau, C. Roy, M. Vala, Joel Anthony Mazer, Francesca Bellini, Christian Holm Christensen, Michelangelo Agnello, Antonio Juan Rubio Montero, Sergey Gorbunov, Yuko Sekiguchi, Alexandre Shabetai, S. Vigolo, Sanjay K. Ghosh, Diego Mauricio Gomez Coral, Petra Riedler, Sarah Louise La Pointe, Alexander Mamonov, Jan Jadlovsky, Linus Feldkamp, Andres Sandoval, Rune Langøy, Roberta Arnaldi, Alexandru Florin Dobrin, Dhananjaya Thakur, Satoshi Yano, Andrei Ionut Herghelegiu, Heiko Engel, D. R. Gangadharan, Stefan Thomas Heckel, Alexander Deisting, Sean Murray, Jan Wagner, Daniel Berenyi, Paolo Martinengo, Alessandro Ferretti, Ivonne Alicia Maldonado Cervantes, Anthony Robert Timmins, Matthias Bonora, Cristina Terrevoli, Gilda Scioli, Bedangadas Mohanty, Adam Ryszard Kisiel, Guillermo Tejeda Munoz, Costin Grigoras, Pradip Kumar Roy, Abraham Villatoro Tello, Fatiha Lehas, Zhang Chunhui, Alexei Khanzadeev, H. Bøggild, E. G. Ferreiro, Ashpreet Kaur Duggal, Adrian Sevcenco, Lukasz Kamil Graczykowski, Alexander Nyanin, Kgotlaesele Senosi, Michal Sumbera, Basanta Kumar Nandi, Svein Lindal, Alexey Kurepin, Rigoberto Cruz Albino, Ping Yang, Christopher Daniel Anson, Bernhard Skaali, Kristin Fanebust Hetland, L. Lazaridis, Riccardo Russo, Renato Angelo Ricci, Rathijit Biswas, Jozef Ferencei, M. An, Nikola Poljak, Torsten Dahms, Andrea Rossi, Eric Endress, Peter Chochula, and A. S. Gonzalez
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, 010308 nuclear & particles physics, Hadron, Nuclear matter, 7. Clean energy, 01 natural sciences, Particle identification, Baryon, Nuclear physics, Heavy Ion Experiments, 0103 physical sciences, lcsh:QC770-798, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, High Energy Physics::Experiment, Rapidity, Impact parameter, Nuclear Experiment, 010306 general physics, Glauber
Abstract: The production of beauty hadrons was measured via semi-leptonic decays at mid-rapidity with the ALICE detector at the LHC in the transverse momentum interval 1
Published: 2017
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42. Production of $${\Sigma (1385)^{\pm }}$$ Σ ( 1385 ) ± and $${\Xi (1530)^{0}}$$ Ξ ( 1530 ) 0 in p–Pb collisions at $${\sqrt{s_{\mathrm{NN}}}= 5.02}$$ s NN = 5.02 TeV

Author: William Llope, Rafael Peretti Pezzi, Annalisa De Caro, Leticia Cunqueiro Mendez, Erin Frances Gauger, M. E. Connors, Linda Vickovic, A. Nedosekin, Xinye Peng, Nicolo Jacazio, Yonghong Zhang, Lukas Gruber, Kohei Terasaki, Premomoy Ghosh, Konstantin Mikhaylov, Anisa Khatun, Leo Clifford Greiner, Mohammad Ahmad Saleh, Christian Lippmann, Luis Gustavo Pereira, Miroslaw Marek Kielbowicz, Michael Henry Oliver, Laurent Bernard Aphecetche, Iwona Anna Sputowska, Nur Hussain, Jesse Thomas Buxton, David Dobrigkeit Chinellato, F. Ronchetti, Madan M. Aggarwal, Lukas Nellen, David Olle Rickard Silvermyr, Martin Schmidt, Barbara Guerzoni, Peter Christiansen, A. Maire, Anton Jusko, Neelima Agrawal, Corrado Cicalo, Ivan Kralik, Miroslav Pikna, Bruno Alessandro, Priyanka Sett, Johannes Lehrbach, Jorge Mercado-perez, Attiq Ur Rehman, Chaosong Gao, Saikat Biswas, Alexander Kurepin, Marie Germain, In-kwon Yoo, Raul Tonatiuh Jimenez Bustamante, Andrey Vasiliev, Mario Sitta, Enrico Scomparin, H. Caines, Sudhir Raniwala, Tatiana Karavicheva, Subikash Choudhury, Denise Aparecida Moreira De Godoy, Mario Rodriguez Cahuantzi, Motoi Inaba, Jin Hee Yoon, Rishat Sultanov, Peter Kalinak, Valery Punin, S.A. Zaporozhets, Marianna Mazzilli, Adriana Telesca, Michelangelo Agnello, Somnath Kar, Ulrich Michael Frankenfeld, Sebastian Rosado Navarro, Benedetto Di Ruzza, Alice Elisabeth Ohlson, Zuman Zhang, Marcello Borri, Alexander Vodopyanov, Alexandr Tumkin, Alexis Jean-michel Mas, Juan Carlos Cabanillas Noris, Satoshi Yano, Pooja Pareek, Andrea Alici, Yves Roland Schutz, Wisla Carena, Martino Gagliardi, Caterina Deplano, Nirbhay Kumar Behera, Daniel Berenyi, Janet Elizabeth Seger, Andrea Francescon, Sona Pochybova, Anatoly Kolozhvari, Anik Gupta, Peter Chochula, A. S. Gonzalez, Christophe Pierre Suire, Roy Crawford Lemmon, Paolo Martinengo, Alessandro Ferretti, Ivonne Alicia Maldonado Cervantes, Anthony Robert Timmins, Andrea Festanti, Jun Takahashi, D. Di Bari, Jana Bielcikova, Alexei Khanzadeev, Robert Vertesi, Bjarte Kileng, Rama Chandra Baral, Peter Graham Jones, Laura Fabbietti, Daiki Sekihata, Smbat Grigoryan, Rainer Martin Schicker, Marcel Araujo Silva Figueredo, Dario Berzano, Ionut Cristian Arsene, Paul Stankus, Ernesto Calvo Villar, Jihye Song, Arturo Tauro, Andrzej Deloff, Lucina Gabriela Espinoza Beltran, Soyeon Cho, J. Book, Rafay Anwar, Sushanta Tripathy, Andre Augustinus, Fabian Ng, Kyungeon Choi, Anju Bhasin, Florian Herrmann, Adam Ryszard Kisiel, Cynthia Marie Hadjidakis, Horst Sebastian Scheid, M. Irfan, Natalia Kondratyeva, Mateusz Andrzej Ploskon, Vladimir Belyaev, Lukasz Kamil Graczykowski, Guillermo Tejeda Munoz, Sumit Basu, M. Kim, Gines Martinez-Garcia, Grazia Luparello, Paraskevi Ganoti, Paolo Giubellino, Federica Sozzi, Cristian Andrei, Venelin Anguelov, Eliane Epple, Julius Maximilian Gronefeld, Sanjib Muhuri, Costin Grigoras, Leonardo Milano, Pierre Vande Vyvre, Philippe Crochet, Massimiliano Marchisone, Deepa Thomas, Andrey Reshetin, Filippo Costa, Grigorii Feofilov, Oleg Karavichev, Maciej Pawel Szymanski, Antonio Ortiz Velasquez, Stefan Thomas Heckel, Zhuo Zhou, Tinku Sarkar Sinha, Boris Batyunya, Mario Ivan Martinez Hernandez, Stefano Piano, Daniel Michael Muhlheim, Sourav Kundu, Alexander Nyanin, Basanta Kumar Nandi, Svein Lindal, Ping Yang, Christopher Daniel Anson, Gerardo Antonio Herrera Corral, Hermann Franz Degenhardt, Ivan Vorobyev, Eleazar Cuautle Flores, Victor Gonzalez, Goran Simatovic, Dennis Franz Weiser, Petr Zavada, Evgeny Kryshen, Yury Ryabov, Sabyasachi Siddhanta, Peter Braun-Munzinger, Sanjeev Singh Sambyal, Luis Alberto Perez Moreno, Valeriy Pozdniakov, Caio Alves Garcia Prado, Michael Linus Knichel, Suharyo Sumowidagdo, Monika Kofarago, Salvatore Aiola, B. K. Srivastava, Vladimir V. Isakov, Deepika Rathee, R. P. Scharenberg, Christina Markert, Przemyslaw Stefan Rokita, Paul Christoph Bätzing, Youngil Kwon, Mikolaj Krzewicki, Sukalyan Chattopadhyay, Marcello Lunardon, Roberto Preghenella, Pedro Hugo Ferreira Natal Da Luz, Marek Chojnacki, Raymond James Ehlers, Ashik Ikbal Sheikh, Philippe Rosnet, Raffaele Grosso, Alessandro Grelli, Kristin Fanebust Hetland, Svetlana Kushpil, Jogender Saini, Christian Schmidt, Vladimir Nikulin, A. Zichichi, D. Domenicis Gimenez, J. Pluta, Livio Bianchi, Evgeny Ryabinkin, Yongwook Baek, Anatoly Tikhonov, Tatsuya Chujo, Ian Gardner Bearden, Bedangadas Mohanty, Ejiro Naomi Umaka, Rathijit Biswas, Jozef Ferencei, Dmitry Mal'kevich, Andrey Zarochentsev, Ajay Kumar, A. Rakotozafindrabe, Alberto Masoni, Pedro Luis Manuel Podesta Lerma, Miljenko Suljic, Sumit Kumar Saha, Bogdan Theodor Rascanu, Benjamin Audurier, B. Erazmus, Boris Hippolyte, Se Yong Kim, Javier Ernesto Castillo Castellanos, Shuaib Ahmad Khan, Martin Vala, Joel Anthony Mazer, Francesca Bellini, Alexander Kluge, Alexey Kuryakin, Filimon Roukoutakis, Ralf Keidel, Harry Arthur Andrews, Audrey Francisco, Thomas Peitzmann, Tuva Ora Herenui Richert, Markus Bernhard Zimmermann, Alice Zimmermann, Lilit Karayan, Aaron Allan Capon, Peter Levai, Siegfried Valentin Foertsch, Zubayer Ahammed, Federico Cindolo, Amalia Pop, Jussi Samuli Viinikainen, Dmitry Finogeev, Karel Safarik, Tomoya Tsuji, Lais Ozelin De Lima Pimentel, Nora De Marco, Gabriele Gaetano Fronze, Franco Meddi, Dmitry Aleksandrov, Adam Tomasz Matyja, Giacomo Vito Margagliotti, Dmitry Budnikov, Rosario Turrisi, Andrea Rossi, Chitrasen Jena, Dmitry Blau, C. Roy, Imrich Szarka, Christian Holm Christensen, Nicole Bastid, Fatiha Lehas, Sergey Gorbunov, Yuko Sekiguchi, Oton Vazquez Doce, Yasuo Miake, Rainer Arno Ernst Renfordt, Andrew Michael Kubera, Vojtech Petracek, Franck Manso, Petr Nomokonov, David Horak, Rashmi Raniwala, Francesca Carnesecchi, Alessandra Fantoni, M. Mohisin Khan, Eleuterio Spiriti, Dimitar Lubomirov Mihaylov, Chinorat Kobdaj, Pascal Dillenseger, Johan Alme, Luciano Ramello, Zhang Chunhui, Daicui Zhou, Mikhail Malaev, Xiangrong Zhu, Ritsuya Hosokawa, Tyler Harrison Lutz, Bernhard Skaali, Fedor Guber, Constantinos Loizides, Gergely Gabor Barnafoldi, Palash Khan, Angela Badala, Soren Pontoppidan Sorensen, Igor Pshenichnov, Christian Klein-Boesing, I. Das, Rene Bellwied, Annika Passfeld, Borge Svane Nielsen, Jan Cabala, Sibaliso Mhlanga, Ester Anna Rita Casula, Evgeny Kondratyuk, Sudipan De, Alexandru Bercuci, Hyeonjoong Kim, Fiorella Maria Celeste Fionda, Sarah Louise La Pointe, Germano Bonomi, Alexandre Alarcon Do Passo Suaide, Dmitry Yurevich Peresunko, Sarah Julie Porteboeuf, Jitendra Kumar, Alexander Mamonov, Raphaelle Marie Bailhache, Dong Jo Kim, Arseniy Shabanov, Camilo Ernesto Lara Martinez, S. Mahajan, Prabhakar Palni, Jan Figiel, Minjung Kim, Vojtech Pacik, Francesco Noferini, Dieter Roehrich, Ionel Stan, Muhammad Umair Naru, Hartmut Hillemanns, Monika Joanna Jakubowska, Yosuke Watanabe, Jovan Milosevic, Klaus Barth, Artem Shangaraev, Hikari Murakami, Mengliang Wang, Esther Montes Prado, Jørgen André Lien, Seongjoo Lee, M. Cherney, S. Vigolo, Linus Feldkamp, Andres Sandoval, Anand Kumar Dubey, Hans Martin Ljunggren, Matti Mikael Mieskolainen, Rune Langøy, Claude Andre Pruneau, Roberto Barbera, Elena Botta, Zhongbao Yin, Roberta Arnaldi, Alexandru Florin Dobrin, Dhananjaya Thakur, Alexander Deisting, Davide Francesco Lodato, Davide Caffarri, Stefano Bagnasco, Johannes Hendrik Stiller, Yury Pestov, Jaime Norman, Matej Oravec, Giulio Usai, Anjali Sharma, Fernando Scarlassara, Dirk Hutter, Thomas Michael Cormier, Lokesh Kumar, Hua Pei, Michal Meres, Tiziano Virgili, Markus Fasel, Jan Jadlovsky, Andrei Ionut Herghelegiu, Heiko Engel, Andile Mothegi Whitehead, Martin Poghosyan, A. R. Reolon, Barbara Jacak, Alexander Philipp Kalweit, E. G. Ferreiro, Ashpreet Kaur Duggal, Adrian Sevcenco, Stefano Panebianco, Michal Kopcik, Thorsten Sven Kollegger, Domenico Colella, William Edward Witt, N. Grion, Christophe Furget, Jean Willy Andre Cleymans, Volker Lindenstruth, Francesca Soramel, Barbara Antonina Trzeciak, Alberto Caliva, Sylvain Chapeland, Myunggeun Song, Lucia Leardini, Ankhi Roy, Jean-Luc Fernand Charvet, Latchezar Betev, Alexey Bogdanov, Hongbo Zhu, Redmer Alexander Bertens, Danilo Silva De Albuquerque, Alexander Borissov, Edgar Perez Lezama, Arturo Fernandez Tellez, Mona Sharma, Manuel Colocci, Martin Andreas Volkl, Vladimir Samsonov, Vardanush Papikyan, Tsubasa Okubo, Sonia Parmar, Dezso Varga, Andrew John Lowe, Pedro Gonzalez Zamora, Alex Henri Jean Chauvin, D. De Gruttola, Alessandra Lattuca, Jochen Klein, Evgeny Karpechev, D. R. Gangadharan, Wanchaloem Poonsawat, Jai Samuel Nielsen Salzwedel, Vladyslav Litichevskyi, Trine Spedstad Tveter, Markus Keil, Eugen Mudnic, Herve Borel, Sean Murray, M. Ivanov, Jan Wagner, D. Watanabe, Supriya Das, Artur Furs, Matthias Bonora, Sergio Vergara Limon, Nicola Bianchi, Cristina Terrevoli, Meike Charlotte Danisch, Ketil Roeed, Ana Maria Marin, Gilda Scioli, Mihai Petrovici, Pasquale Di Nezza, Federico Antinori, Elisa Meninno, Sanchari Thakur, Christine Nattrass, Giuseppe Pappalardo, Ermanno Vercellin, Alberto Baldisseri, Artem Konevskikh, Tahir Hussain, Debojit Sarkar, Vladislav Manko, Yasser Corrales Morales, Gianluca Aglieri Rinella, Ivan Kisel, Rinaldo Rui, Qiye Shou, Lee Stuart Barnby, Piero Giubilato, Ara Grigoryan, Peter Glassel, R. Scott, Christian Bourjau, Marielle Chartier, Bruno Espagnon, Maria Vasileiou, Gerardus Nooren, Jan Musinsky, Jorn Henning Putschke, Ombretta Pinazza, Hiroki Yokoyama, Miguel Martinez Pedreira, Michal Broz, Alberto Rotondi, V. Paticchio, Vladimir Kovalenko, Nachiketa Sarkar, C. Ceballos Sanchez, Jan Pospíšil, Kirill Lapidus, Thomas Humanic, P. Pillot, Uzma Tabassam, Pradip Kumar Roy, Nicole Alice Martin, Kunal Garg, Antonio Uras, Sandun Pahula Hewage, Stefania Beole, Oliver Werner Arnold, Inayat Rasool Bhat, Maximiliano Puccio, Raimond Snellings, Bernd Stefan Windelband, Renato Aparecido Negrao De Oliveira, Varlen Grabski, Maciej Slupecki, Jens Joergen Gaardhoeje, G. Puddu, Xavier Bernard Lopez, Jaroslav Bielcik, Pietro Cortese, Emilia Leogrande, Abraham Villatoro Tello, James Declan Mulligan, H. Zhang, Kai Oliver Schweda, Sergey Evdokimov, Vladimir Peskov, Jurgen Schukraft, Sang Un Ahn, Valentina Zaccolo, Petra Loncar, Hans Rudolf Schmidt, Subhasis Chattopadhyay, Jeremy John Wilkinson, Francesco Barile, Elena Rogochaya, Enrico Fragiacomo, Victor Trubnikov, Rama Narayana Singaraju, Daniela Fabris, Irais Bautista Guzman, Justin Thomas Blair, Jana Crkovská, Yajun Mao, Viktor Ratza, Jamila Bashir Butt, Marton Vargyas, Antonio Di Mauro, Anders Nils Erik Oskarsson, Andre Mischke, Dagmar Adamová, Maurizio Basile, F. R. Grull, Tomas Vanat, Slavka Jadlovska, Guy Paic, Alberto Collu, Pranjal Sarma, Ilya Selyuzhenkov, Jose Antonio Lucio Martinez, Nima Zardoshti, Alexandre Shabetai, Sanjay K. Ghosh, Jose Ruben Alfaro Molina, Cristiane Jahnke, Joakim Nystrand, Baidyanath Sahoo, Julien Faivre, Marian Krivda, Preeti Dhankher, Hendrik Poppenborg, Christoph Mayer, Sampo Saarinen, Janusz Oleniacz, Christian Claude Kuhn, Samrangy Sadhu, Yury Sibiryak, Benjamin Andreas Hess, Maria Nicassio, Anton Andronic, D. H. Kim, Boris Polishchuk, Pradip Kumar Sahu, Danthasinghe Piyarathna, Tome Anticic, Sergio Arturo Iga Buitron, Carlos Duarte Galvan, Naoto Tanaka, Fabrizio Grosa, Buddhadeb Bhattacharjee, Rosario Nania, Valerii Kondratev, Suh-urk Chung, Liudmila Malinina, Diego Mauricio Gomez Coral, Petra Riedler, Rudiger Haake, Julien Charles Hamon, Stefano Trogolo, Mike Henry Petrus Sas, Mohamad Tarhini, Sebastian Lehner, P. Cerello, Gabor Biro, Naghmeh Mohammadi, Ankita Sharma, Xiaowen Ren, Sergey Filchagin, Marco Bregant, Jacopo Margutti, Boris Wagner, Chiara Bianchin, Aditya Nath Mishra, Roberto Divia, Grzegorz Andrzej Wilk, Jan Hladky, Vladislav Grigoryev, Sarita Sahoo, Yvonne Chiara Pachmayer, Matthias Richter, Alessandro Feliciello, Katherin Shtejer Diaz, Patrick Simon Reichelt, Sergey Nazarenko, Baldo Sahlmuller, Leonid Vinogradov, Gabor Kiss, Tyler Allen Browning, Ismael Cortes Maldonado, Elena Bruna, Andrea Dubla, Ju Hwan Kang, R. Varma, Edith Zinhle Buthelezi, Johanna Stachel, Sergey Nikolaev, Prakhar Garg, Anastasia Maria Barbano, Richard Daniel Majka, Eugenio Scapparone, Ante Bilandzic, Mohd Danish Azmi, Astrid Vauthier, Peter Malzacher, A. Szczepankiewicz, R. Orava, Yaroslav Berdnikov, Katarina Krizkova Gajdosova, Ramona Lea, Panagiotis Christakoglou, Antonio Juan Rubio Montero, Shinichi Hayashi, Jonghan Park, Giuseppe Bruno, Vasco Miguel Chibante Barroso, Luca Barioglio, Brigitte Cheynis, Carsten Klein, Samsul Islam, Philipp Johannes Luettig, Oeystein Djuvsland, Bharati Naik, Matteo Lupi, Nikolay Zavyalov, Felix Reidt, Lawrence Pinsky, D. B. Rana, Marten Ole Schmidt, Susanta Kumar Pal, Austin Vincent Harton, Cvetan Valeriev Cheshkov, Ildefonso Leon Monzon, Radiy Ilkaev, Jihyun Bhom, Hideki Hamagaki, Alla Maevskaya, Giuseppe Simonetti, Ivan Ravasenga, Klaus Johannes Reygers, Astrid Morreale, Yuri Melikyan, Olja Dordic, Ken Suzuki, Surya Prakash Pathak, Anselmo Margotti, Shyam Kumar, Raghunath Sahoo, Fouad Rami, Valerie Ramillien Barret, W. Park, Mikhail Zhalov, Evert Anders Stenlund, Ralf Peter Averbeck, Jacobus Willem Van Hoorne, Mirko Planinic, Dominik Voscek, Hanna Paulina Zbroszczyk, Toru Sugitate, Michele Floris, Serhiy Senyukov, Mohammad Tariq, Oliver Busch, Annalisa Mastroserio, Debasish Das, Andreas Morsch, Kirill Voloshin, Shingo Sakai, Jongsik Eum, Stefan Kirsch, Ali Zaman, Sergey Nikulin, V. Petrov, Shakeel Ahmad, Kgotlaesele Senosi, Michal Sumbera, Jacobus Onderwaater, Silvia Arcelli, Uwe Westerhoff, Domenico Elia, Victor Jose Gaston Feuillard, Ranbir Singh, Vladimir Ivanov, Simon Voigt Nesbø, Mandeep Kour, J. W. Harris, Mauro Gallio, Chiara Oppedisano, Didier Alexandre, Mais Kazim Oglu Suleymanov, Laurent Ducroux, Pragati Sahoo, Alexey Kurepin, L. Lazaridis, Krzysztof Marek Sielewicz, Malgorzata Anna Janik, Junjie Zhu, Gergoe Hamar, Hector Bello Martinez, Antoine Xavier Lardeux, Jerzy Gustaw Bartke, Boris Teyssier, Konstantin Munning, Dariusz Czeslaw Miskowiec, Do-Won Kim, Marco Marquard, Beomsu Chang, Corey James Myers, Sergey Sadovskiy, Riccardo Russo, Renato Angelo Ricci, Piotr Jan Gasik, Vikas Singhal, Elisa Laudi, Sibaji Raha, Filip Erhardt, Chiara Zampolli, Tatiana Drozhzhova, Catalin-Lucian Ristea, R Jefferson Porter, Jinsook Kim, Hongkai Wang, Silvia Masciocchi, M. An, Nikola Poljak, Torsten Dahms, Theo Alexander Broker, Marcelo Gameiro Munhoz, Valeria Muccifora, Sk Noor Alam, Despina Hatzifotiadou, D. Vranic, Vitaly Loginov, Marko Jercic, Alexander Vinogradov, Ganesh Jagannath Tambave, Marco van Leeuwen, Eric Endress, Harald Appelshaeuser, A. Rachevski, Jan de Cuveland, Massimo Masera, Kenta Shigaki, Ayben Karasu Uysal, Catherine Micaela Silvestre, Lidia Maria Gorlich, Kenneth Francis Read, Zaida Conesa del Valle, Paolo Camerini, Sergey Voloshin, Renaud Vernet, Henner Buesching, Erik Brücken, Stefania Bufalino, Podist Kurashvili, Dae Sung Hwang, ShinIchi Esumi, Mario Fusco Girard, Biswarup Paul, Vladimir Kaplin, Vytautas Vislavicius, Jeremi Niedziela, Andrew John Castro, Paulus Gerardus Kuijer, Steffen Georg Weber, Paolo Pagano, Alessandra Maria Mazzoni, Giulio Eulisse, Kishora Nayak, Shu Li, Sonia Rajput, Kilian Eberhard Schwarz, Ruben Shahoyan, Janka Vrlakova, Oksana Shadura, Marek Kowalski, David H. Evans, Antonio Carlos Oliveira da Silva, Aurora Diozcora Vargas Trevino, Peter Zahariev Hristov, Ken Oyama, Friederike Bock, M. A. Lisa, Gyula Bencedi, Giuseppe Trombetta, Peter Martin Jacobs, Jon Christopher Wikne, Alessandro De Falco, Charles E. Hughes, Ramni Gupta, Predrag Buncic, Rafael Derradi De Souza, Wladyslaw Henryk Trzaska, Maitreyee Mukherjee, Madalina-Gabriela Tarzila, Laszlo Boldizsar, Paola Gianotti, Annelies Marianne Veen, Vito Manzari, Satyajit Jena, Jasper Van Der Maarel, Arvind Khuntia, Viktor Riabov, Rajendra Nath Patra, Serpil Yalcin, Diego Stocco, Gennady Zinovjev, Susanna Costanza, Sadhana Dash, Paola La Rocca, Edmundo Javier Garcia-Solis, Ranjit Nayak, Bastian Bathen, Henrik Qvigstad, Orlando Villalobos Baillie, Jan Fiete Grosse-Oetringhaus, Sven Gotovac, Zabulon Vilakazi, Roman Lavicka, Arturo Alejandro Menchaca-Rocha, Igor Altsybeev, Davide Pagano, Jiri Mares, Jesus Guillermo Contreras Nuno, Laszlo Olah, Marek Bombara, Ernst Hellbar, Andreas Michael Mathis, Prabhat Ranjan Pujahari, Peter Strmen, Udo Wolfgang Kebschull, Pascal Dupieux, Vladimir Vechernin, Andrea Dainese, Sergey Fokin, Torsten Alt, Mahmut Ozdemir, Eugenio Nappi, Kristjan Herlache Gulbrandsen, Charalampos Kouzinopoulos, Johannes Peter Wessels, Gustavo Conesa Balbastre, Sagarika Swain, Bernhard Franz Ketzer, Alberica Toia, Magnus Mager, Pietro Antonioli, Rachid Guernane, Luisa Cifarelli, Enrichetta Maria Fiore, Ewa Gladysz-dziadus, Jan Rak, Rahul Ramachandran Nair, Sebastian Zimmermann, Adela Kravcakova, Guido Alexander Willems, Xiaoming Zhang, Taesoo Kim, Camila De Conti, Cristina Bedda, Katie Leanne Graham, Johann Zmeskal, Lucile Ronflette, Eulogio Serradilla Rodriguez, Greeshma Koyithatta Meethaleveedu, Sergey Kiselev, Yury Kharlov, Luciano Musa, Sebastian Klewin, Vladimir Izucheev, Marc Weber, Krzysztof Redlich, Sami Sakari Rasanen, Ashutosh Pandey, Jubin Mitra, Chengxin Zhao, Alberto Martin Gago Medina, Oleksandr Kovalenko, Jacek Tomasz Otwinowski, Salvatore De Pasquale, Teodor Siemiarczuk, Andres Gomez Ramirez, Jiyoung Kim, Crispin Williams, Claudiu Cornel Schiaua, Igor Lakomov, Benjamin Donigus, Sandra Moretto, Andrea Danu, Guillaume Batigne, Ajay Kumar Dash, Hugo Denis Antonio Pereira Da Costa, Xiaomei Li, Helmut Oskar Oeschler, Miguel Angel Diaz Corchero, Volodymyr Yurchenko, Antonija Utrobicic, Renu Bala, Christoph Blume, Andrzej Rybicki, Monika Sharma, Vit Kucera, Ciprian Mihai Mitu, Anar Rustamov, Esther Bartsch, Paolo Bartalini, Giacomo Volpe, Natasha Sharma, Mikhail Ippolitov, Natalia Zhigareva, David Michael Rohr, Mauro Rogerio Cosentino, Jose Garabatos Cuadrado, Fabio Filippo Colamaria, Haavard Helstrup, Giacinto de Cataldo, Hans Peter Beck, Anders Garritt Knospe, Iouri Belikov, Thomas Dietel, Roman Lietava, You Zhou, Sohail Musa Mahmood, Taku Gunji, Francesco Prino, Anton Alkin, Paul Alois Buhler, Jens Wiechula, Mihai Niculescu, Darius Keijdener, Francesco Carena, Ernesto Lopez Torres, Min Jung Kweon, Alexander Akindinov, Per-Ivar Lønne, Tomas Wilhelm Snellman, Jinjin Pan, A. K. Bhati, Nikolai Smirnov, Raphael Noel Tieulent, Markus Ball, Sedat Altinpinar, T. K. Nayak, Arianna Batista Camejo, Robert Helmut Munzer, Saehanseul Oh, Alexander Szabo, Filip Krizek, Branislav Sitar, Barthelemy von Haller, Catia Petta, Sidharth Kumar Prasad, Arild Velure, Kjetil Ullaland, Francesco Riggi, Gianluigi Boca, Panagiota Foka, Mesut Arslandok, Caio Lagana Fernandes, Michal Sefcik, Werner Riegler, Henrique Jose Correa Zanoli, Jennifer Lynn Klay, V. Lenti, Ulrich Fuchs, Corrado Gargiulo, and Manoj Bhanudas Jadhav
Subjects: Physics, Particle physics, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, Computer Science::Information Retrieval, Hadron, Astrophysics::Instrumentation and Methods for Astrophysics, Hyperon, Computer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing), Strangeness, 01 natural sciences, Pion, Excited state, 0103 physical sciences, Transverse momentum, Computer Science::General Literature, Rapidity, Multiplicity (chemistry), Nuclear Experiment, 010306 general physics, Engineering (miscellaneous)
Abstract: The transverse momentum distributions of the strange and double-strange hyperon resonances ([Formula: see text], [Formula: see text]) produced in p-Pb collisions at [Formula: see text] TeV were measured in the rapidity range [Formula: see text] for event classes corresponding to different charged-particle multiplicity densities, [Formula: see text]d[Formula: see text]/d[Formula: see text]. The mean transverse momentum values are presented as a function of [Formula: see text]d[Formula: see text]/d[Formula: see text], as well as a function of the particle masses and compared with previous results on hyperon production. The integrated yield ratios of excited to ground-state hyperons are constant as a function of [Formula: see text]d[Formula: see text]/d[Formula: see text]. The equivalent ratios to pions exhibit an increase with [Formula: see text]d[Formula: see text]/d[Formula: see text], depending on their strangeness content.
Published: 2017
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43. A rare cause of acute gastrointestinal hemorrhage: ileal lipoma Case report

Author: E, Manna, Fabrizio Maria, Frattaroli, E, Polettini, Aldo, Nunziale, and Giuseppe, Pappalardo
Subjects: Diagnosis, Differential, Male, Treatment Outcome, Ileum, Humans, Lipoma, Gastrointestinal Hemorrhage, Tomography, X-Ray Computed, Digestive System Surgical Procedures, Aged
Abstract: Primary small bowel tumors account for 1-6% of all Gastrointestinal (G.I.) tract malignancies. Among these pedunculated lipomas are unusual. We report a case of a 66-year-old male with a history of G.I. hemorrhage and acute anemia, negative upper and lower endoscopies and a pedunculated lipoma in distal ileum, revealed by CT enterography. The patient was successfully treated by open surgery. Patients with G.I. hemorrhage and negative upper and lower endoscopies need an accurate evaluation of small bowel. Multislice CT enterography or Magnetic Resonance enteroclysis/ enterography represent the fastest and more accurate tools to obtain an exhaustive evaluation of small bowel. In case of small bowel tumors this diagnostic procedures can show site and stage and can even suggest histological type of such neoplasms, with a significant impact in the surgical planning, avoiding time consuming surgical exploration. In this patient multislice TC enterography allowed a correct diagnosis of benign lipoma due to its radiological density and absence of infiltration of the intestinal wall and surrounding tissues.CT enterography, Gastrointestinal hemorrhage, Lipoma, Small bowel.I tumori primitivi del piccolo intestino rappresentano il 1-6% di tutte le neoplasie maligne del tratto gastrointestinale (GI). Tra questi i lipomi peduncolati sono insoliti. Riportiamo il caso di un uomo di 66 anni con una storia di emorragia GI ed anemia acuta, in cui gli esami endoscopici (EGDS e RSCS) risultavano negativi. Alla TC multislice con enterografia virtuale si evidenziava lipoma peduncolato dell’ileo terminale. Il paziente è stato trattato con successo con chirurgia open seguita da rapido decorso p.o. I pazienti con emorragia GI ed anemia acuta con esami endoscopici negativi necessitano di una valutazione accurata del piccolo intestino. La TC multislice con enterografia virtuale o la Risonanza Magnetica con enteroclisi/ enterografia rappresentano gli strumenti più veloci e più accurati per ottenere una valutazione esaustiva. In caso di tumori del piccolo intestino queste procedure diagnostiche sono in grado di dimostrare il sito e lo stadio e in alcuni casi, possono anche suggerire il tipo istologico di tali neoplasie, con un impatto significativo nella pianificazione chirurgica, riducendo i tempi operativi esplorativi. In questo paziente la TC multislice con enterografia a permesso di arrivare ad una corretta diagnosi di lipoma benigno, dovuta alla tipica densità radiologica del lipoma e all’assenza di infiltrazione della parete intestinale e dei tessuti circostanti.
Published: 2017

44. Open sphincter-preserving surgery of extraperitoneal rectal cancer without primary stoma and Fast Track Protocol

Author: Giannella A, De Lucia F, Giuseppe Pappalardo, Ruffolo F, Saverio Coiro, and Fabrizio Maria Frattaroli
Subjects: Male, medicine.medical_specialty, Time Factors, Colorectal cancer, Anal Canal, Sphincter preserving surgery, Stoma, 03 medical and health sciences, 0302 clinical medicine, T-group, Clinical Protocols, medicine, Humans, In patient, 030212 general & internal medicine, Digestive System Surgical Procedures, Aged, Aged, 80 and over, business.industry, Rectal Neoplasms, Middle Aged, medicine.disease, Digestive System Surgical Procedures, methods, Female, Organ Sparing Treatments, Quality of Life, Rectal Neoplasms, surgery, Surgery, Anastomotic leakage, 030220 oncology & carcinogenesis, Perioperative care, Original Article, Fast track, business
Abstract: AIM Fast track protocol (FTP) showed to improve perioperative care. The study aims to evaluate the impact of the FTP in the open extraperitoneal rectal cancer (ERC) surgical treatment without a primary derivative stoma (DS) and the QoL in patients with or without a secondary DS. PATIENTS AND METHODS 50 patients affected by ERC were enrolled and operated on with open low anterior resection without a primary DS. They were randomized in two groups: one was treated perioperativelly in the traditional way (group T), the other using a modif ed FTP (group FT). A QoL questionnaire was administered prior to discharge and at 1-month follow-up. RESULTS Five courses (10%) were complicated by anastomotic leakage: 3 (12%) in the FT group (2 minor and 1 maior) and 2 (8%) in the T group (1 minor and 1 maior) (p=n.s.). All the maiors and one minor were treated with a DS. Patients of the group FTP were considered dischargeable earlier that those of group T (p
Published: 2017

45. Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC

Author: Marcel Araujo Silva Figueredo, F. Tosello, Anju Bhasin, G. A. Feofilov, A. Baldit, Xianguo Lu, Raphaelle Marie Bailhache, Paolo Giubellino, Pierre Vande Vyvre, Antonio Ortiz Velasquez, S. Puchagin, Mikolaj Krzewicki, M. Botje, Raffaele Grosso, L. Manceau, S. Böttger, Giuseppe Pappalardo, Giuseppe Viesti, R. Ferretti, V. Pospíšil, Tinku Sarkar Sinha, Shuaib Ahmad Khan, Jongik Yoon, Ermanno Vercellin, B. Ghidini, A. Kolojvari, Alessandro Grelli, Naomi van der Kolk, Chiara Zampolli, Youngil Kwon, Peter Glassel, Yasser Corrales Morales, Sara Vallero, Sudipan De, L. Jirden, Rosario Nania, Saul Aguilar Salazar, Francesco Noferini, K. Strabykin, Mengliang Wang, P. A. Scott, Andrey Zarochentsev, Sabyasachi Siddhanta, Tatjana Susa, H. J. Jang, A. I. Pavlinov, A. Nedosekin, K. Polák, V. P. Kondratiev, T. Breitner, Federico Antinori, Andrey Vasiliev, Enrico Scomparin, C. Bergmann, Hyung Taik Jung, Oleksii Ivanytskyi, Daniel Tapia Takaki, Davide Falchieri, Michal Broz, Yves Le Bornec, Anders Nils Erik Oskarsson, Benjamin Donigus, Maurizio Basile, Subhasis Chattopadhyay, Terry C Awes, Z. L. Matthews, Alberto Masoni, M. Petris, Francesco Barile, Daniela Fabris, P. Zelnicek, Marian Krivda, Raoul Stefan de Rooij, Mikhail Stolpovskiy, Gerardus Nooren, Grzegorz Andrzej Wilk, Bogdan Theodor Rascanu, Joakim Nystrand, Natasha Sharma, Yifei Wang, Andrey Kazantsev, B. Polichtchouk, Janusz Oleniacz, Fatima Padilla, Fiorella Fionda, Thomas Peitzmann, M. Spyropoulou-Stassinaki, Marcelo Gameiro Munhoz, Valeria Muccifora, Fabrizio Coccetti, Suh-urk Chung, Jun Takahashi, Jan de Cuveland, Massimo Masera, Jana Bielcikova, Sebastian Kalcher, Domenico Colella, J. S. Kim, J. Thäder, ShinIchi Esumi, Mario Fusco Girard, Vladimir Samsonov, Matthias Richter, Chamath Kottachchi Kankanamge Don, M. Cherney, Lawrence Pinsky, Jochen Klein, F. Bossú, Thomas Michael Cormier, M. Steinpreis, R. Romita, Petr Zavada, Deepika Rathee, R. P. Scharenberg, Christina Markert, M. Kim, Bjarte Kileng, Aditya Nath Mishra, Christine Nattrass, Rama Chandra Baral, Vladimir Kaplin, Marek Kowalski, M. A. Lisa, Michal Sumbera, Hans Muller, L. Cunqueiro, Alberica Toia, Nicolas Bock, Susanta Kumar Pal, Mikhail Zhalov, Evert Anders Stenlund, Tomasz Traczyk, Peter Graham Jones, D. Emschermann, M. Pachr, A. Musso, L. Jancurová, Nicola Bianchi, Paul Constantin, R. A. Soltz, M. Boccioli, Alexey Kurepin, Gyulnara Eyyubova, Ante Bilandzic, Jose Ruben Alfaro Molina, A. M. Gago, Dosatsu Sakata, Andreas Morsch, Ombretta Pinazza, Hiroki Yokoyama, Y. Wang, Markus Fasel, Philippe Pillot, L. Cifarelli, Alexis Jean-Michel Mas, Alexander Akindinov, A. G. Asryan, P. Gros, I. Martashvili, Florian Painke, M. Heide, Lee Stuart Barnby, A. B. Kaidalov, Pedro Luis Manuel Podesta Lerma, M. Mastromarco, Smbat Grigoryan, A. Palmeri, Uwe Westerhoff, Leonid Vinogradov, A. Pesci, T. Virgili, N. Pitz, Stefan Kirsch, Johanna Stachel, S. Kox, Rainer Martin Schicker, Alexandre Alarcon Do Passo Suaide, Ernesto Calvo Villar, Grazia Luparello, Mads Stormo Nilsson, Paraskevi Ganoti, Andrzej Deloff, Paolo Pagano, Alessandra Maria Mazzoni, R. W. Fearick, B. V.K.S. Potukuchi, E. Chiavassa, Ruben Shahoyan, Evgeny Karpechev, Janka Vrlakova, Laurent Ducroux, Juha Äystö, D. Felea, J. Book, Danthasinghe Piyarathna, Elena Bruna, Cesar Guerra Gutierrez, Karel Safarik, Tomoya Tsuji, Xavier Bernard Lopez, Jaroslav Bielcik, Marco Monteno, Renato Angelo Ricci, Patrick Simon Reichelt, J. H. Kim, L. Leistam, E. Crescio, M. Bach, Andrei Gheata, R. Gomez, Valerie Ramillien Barret, Oeystein Djuvsland, Ildefonso Leon Monzon, Ionut Cristian Arsene, Alexander Vinogradov, Isabel Dominguez, Hyungsuk Son, Arian Abrahantes Quintana, R. Santo, C. Søgaard, H. León, Elisa Incani, Cenek Zach, A. K. Bhati, L. Luquin, Deepa Thomas, Myunggeun Song, Satish Sharma, Andrea Agostinelli, S. Lohn, Enrico Fragiacomo, T. Aronsson, Sang Un Ahn, Stanislav Yasnopolsky, Radiy Ilkaev, F. Blanco, Boris Batyunya, Alexei Khanzadeev, H. Bøggild, J. Lehnert, Peter Kalinak, Valery Punin, S.A. Zaporozhets, G. Ortona, Klaus Johannes Reygers, Sergey Nazarenko, Betty Abelev, Jeewon Seo, Tome Anticic, C. A. Carrillo Montoya, G. Nazarov, Mohisin Mohammed Khan, Domenico Elia, S. K. Pal, Adriana Telesca, Lukasz Kamil Graczykowski, Xitzel Sanchez Castro, Linda Vickovic, P. I. Loenne, Stefano Piano, A. Rossi, A. Zichichi, M. Sano, Xu Cai, J. Pluta, Jean-Pierre Michel Coffin, Yasuo Miake, Maya Hachiya Shimomura, A. Maire, D. P. Mahapatra, Nikolai Smirnov, V. Lenti, B. Grinyov, Lizardo Valencia Palomo, Raphael Noel Tieulent, Luis Manuel Montano Zetina, Rishat Sultanov, Cvetan Valeriev Cheshkov, M. Perales, Jurgen Schukraft, K. Das, Christian Lippmann, Massimiliano Marchisone, Anton Andronic, Andre Augustinus, R. Kour, Rama Narayana Singaraju, M. Bogolyubsky, Alexander Kurepin, Evgeny Ryabinkin, Vasco Miguel Chibante Barroso, Brigitte Cheynis, Yaxian Mao, L. Molnar, Se Yong Kim, M. Zynovyev, D. Truesdale, Dmitry Finogeev, Vojtech Petracek, Anton Jusko, Sorin Ion Zgura, Gergoe Hamar, Ivan Kralik, Miroslav Pikna, Mario Sitta, T. Horaguchi, Palash Khan, Giacomo Contin, Nora De Marco, Dmitry Mal'kevich, L. K. Mangotra, Ulrich Fuchs, Andrea Alici, Marie Germain, Ulrich Michael Frankenfeld, Z. Harmanova, Juan Francisco Castillo Hernandez, V. Kakoyan, Raimond Snellings, J. Mlynarz, A. Nyatha, Annalisa De Caro, Andrey Reshetin, Julien Faivre, Subhash Singha, Sukalyan Chattopadhyay, Marcello Lunardon, Annika Passfeld, G.S. Shabratova, Sedat Altinpinar, Sergio Serci, T. K. Nayak, Rongrong Ma, Davide Caffarri, Taku Gunji, Ionel Stan, David Dobrigkeit Chinellato, Raphaelle Ichou, S. Navin, Rainer Arno Ernst Renfordt, J. S. Real, Francesco Prino, Petr Nomokonov, Alexandr Tumkin, M. Hartig, Jochen Gerhard, V. Nikolic, Basanta Kumar Nandi, Stefania Bufalino, Luke David Hanratty, Meidana Huang, Svein Lindal, Jesus Guillermo Contreras, Vardanush Papikyan, J. Ulrich, Markus Konrad Kohler, Udo Kebschull, Hideki Hamagaki, Gunnar Løvhøiden, David Olle Rickard Silvermyr, Arturo Tauro, M. Lenhardt, Yaroslav Berdnikov, Rashmi Raniwala, Sergey Sadovsky, Anselmo Margotti, Claudio Bortolin, Giulio Usai, R. Scott, Anton Alkin, Satoshi Yano, Rinaldo Baldini Ferroli, Daniel Berenyi, H. Delagrange, T. Dobrowolski, Airton Deppman, V. R. Loggins, Yury Pestov, Dmitry Budnikov, D. Perrino, J. Yi, Claude Andre Pruneau, Franco Meddi, Sung Chul Lee, Barbara Guerzoni, M. Fragkiadakis, Yves Roland Schutz, A. Diaz, K. Ma, Peter Christiansen, C. Pajares, Bernhard Skaali, Kristin Fanebust Hetland, Svetlana Kushpil, Vladislav Manko, Ki Sang Lee, Panagiotis Christakoglou, Antonio Juan Rubio Montero, L. Toscano, Roberto Barbera, Edgar Perez Lezama, Arturo Fernandez Tellez, Zhongbao Yin, Hans Rudolf Schmidt, Amalia Pop, Dagmar Adamová, Rachid Guernane, A. Korneev, Paolo Martinengo, S. Bose, Dmitry Aleksandrov, Alessandro Ferretti, Franck Manso, M. Kliemant, Philipp Johannes Luettig, Bogdan Vulpescu, Elienos Pereira De Oliveira Filho, Vladimir Peskov, J. W. Harris, Plamen Rumenov Petrov, Alla Maevskaya, Javier Ernesto Castillo Castellanos, Gerardo Antonio Herrera Corral, R. Grajcarek, G.F. Segato, Alexander Kluge, Mauro Gallio, D. I. Patalakha, Alex Hansen, Imrich Szarka, Nicole Bastid, Madan M. Aggarwal, P. Crochet, S. Huber, Daniel Lohner, Ranbir Singh, Ivonne Alicia Maldonado Cervantes, Anthony Robert Timmins, Adam Ryszard Kisiel, Pasquale Di Nezza, Igor Pshenichnov, I. Das, Francesco Carena, Alexander Philipp Kalweit, Olja Dordic, V. Altini, N. P. Naumov, Hege Austrheim Erdal, Premomoy Ghosh, Cristian Andrei, Gaute Vrebekk, Venelin Anguelov, A. V. Ivanov, Nazeer Ahmad, Fernando Scarlassara, Eugen Mudnic, A. K. Dutta Majumdar, Jorn Henning Putschke, I. K. Yoo, Silvia Masciocchi, Corrado Cicalo, C. Cavicchioli, Guillermo Tejeda Munoz, Frederick Kramer, Costin Grigoras, Leonardo Milano, W. Yu, Zubayer Ahammed, Ernesto Lopez Torres, O. Driga, Jan Figiel, M. Vajzer, Alexandre Shabetai, O. Vikhlyantsev, Raul Tonatiuh Jimenez Bustamante, B. S. Nilsen, Adam Tomasz Matyja, Giacomo Vito Margagliotti, M. Veldhoen, Jovan Milosevic, Ian Gardner Bearden, Martijn Reicher, T.A. Pocheptsov, Alessandra Fantoni, Kenta Shigaki, C. Lara, Ayben Karasu Uysal, Michael Linus Knichel, Hanna Paulina Zbroszczyk, Gines Martinez Garcia, Y. Sibiriak, Jose Garabatos, H. A. Torii, Veronica Canoa Roman, Sami Sakari Rasanen, T. S. Räihä, Dmitry Blau, C. Roy, Toru Sugitate, Michele Floris, Alina Gabriela Grigoras, Livio Bianchi, Jorge Mercado Perez, Ana Maria Marin, J. H. Thomas, I. Garishvili, M. Estienne, Rosa Anna Fini, Angela Badala, P. Ostrowski, K. K. Loo, Luciano Ramello, Renaud Vernet, Daicui Zhou, C. Klein-Bösing, Jumpei Midori, S. Sano, K. Watanabe, C.J. Schmidt, Jean-Luc Fernand Charvet, Latchezar Betev, J. J. Gaardhøje, Alexey Bogdanov, Wisla Carena, Martino Gagliardi, Ajit Kumar Mohanty, Alexey Kuryakin, Filimon Roukoutakis, Evgeny Kryshen, A. S. Nyanin, Hermes Leon Vargas, Eduardo Del Castillo Sanchez, Dong Jo Kim, K. Bugaiev, Petra Riedler, Andrew Marshall Adare, Iwona Anna Sputowska, D. Perini, Sona Pochybova, Federico Cindolo, Anik Gupta, V. Kushpil, V. Grigoriev, L. Šándor, Alberto Baldisseri, J. Ban, Andry Malala Rakotozafindrabe, Pietro Cortese, Ester Anna Rita Casula, Kirill Voloshin, M. Venaruzzo, B. S. Chang, G. Steyn, Saehanseul Oh, Kilian Eberhard Schwarz, S. Schuchmann, D. Di Bari, P. T. Hille, Sergey Gorbunov, Marco Bregant, Branislav Sitar, Frederic Lefevre, Chiara Oppedisano, A.S. Vodopianov, Antonio Di Mauro, Federico Ronchetti, Barthelemy von Haller, Catia Petta, Takafumi Niida, G. M. Urciuoli, Andre Mischke, Christian Claude Kuhn, C. Ivan, A. Jacholkowski, S. H. Kim, Kjetil Ullaland, Bikash Sinha, Melinda Siciliano, Vladimir Ivanov, N. Grion, Mario Ivan Martinez, Dominik Fehlker, Jihye Song, Anand Kumar Dubey, H. H. Gutbrod, Roberto Preghenella, E. Belmont-Moreno, T. Moon, Francesco Riggi, Aurora Diozcora Vargas, M. Irfan, Martin Vala, I. Ilkiv, Øystein Senneset Haaland, Carlos A. Salgado, Christophe Furget, Jean Willy Andre Cleymans, Volker Lindenstruth, Francesca Soramel, C. D. Anson, Stefan Thomas Heckel, Panagiota Foka, Erick Jonathan Almaraz Avina, Marek Chojnacki, Laurent Bernard Aphecetche, Herve Borel, Y. Kucheriaev, Mesut Arslandok, H. Appelshäuser, Carmelo Di Giglio, Cristina Lazzeroni, P. Cerello, Linus Feldkamp, Andres Sandoval, Rune Langøy, Pradip Kumar Sahu, M. Krus, Werner Riegler, S. Jangal, Jerzy Gustaw Bartke, Jennifer Lynn Klay, H. Sakaguchi, B. Pastirčák, P. González-Zamora, E. Serradilla, Mikhail Malaev, A. Arend, I. Berceanu, Borge Svane Nielsen, Xiangrong Zhu, Sylvain Chapeland, Alexander Borissov, Roberta Arnaldi, Arshad Ahmad, D. De Gruttola, Michal Meres, Bedangadas Mohanty, Sanjib Muhuri, T. Krawutschke, Giuseppe Bruno, Bruno Alessandro, Sergey Nikolaev, Sergio Vergara, Sudhir Raniwala, Tatiana Karavicheva, D. C. Vernekohl, I. Kraus, Rinaldo Rui, V. Catanescu, Peter Chochula, A. Hayrapetyan, D. Mayani, Denise Aparecida Moreira De Godoy, B. Hicks, H. Caines, Motoi Inaba, Y. Zoccarato, Mihai Petrovici, Romualdo Santoro, Cristina Terrevoli, Christophe Pierre Suire, T.M. Steinbeck, R. Wan, Mario Rodriguez Cahuantzi, Ilya Selioujenkov, Henning Kværnø, Sergey Nikulin, Cinzia Luzzi, Gilda Scioli, Eugenio Scapparone, Ara Grigoryan, A. R. Reolon, Norbert Herrmann, Martin Alfonso Subieta Vasquez, Ivana Hrivnacova, Giovanni Cara Romeo, Pradip Kumar Roy, Hans Hjersing Dalsgaard, N. Novitzky, Bernd Stefan Windelband, A. A. Rademakers, Varlen Grabski, C. Nygaard, J. Sarkamo, Néstor Armesto, Jiri Kral, Henner Buesching, A. Palaha, Min Jung Kweon, V. Wagner, I. E. Yushmanov, E. G. Ferreiro, R. Smakal, Debasish Das, Pedro Ladron de Guevara, Xiaoming Zhang, Adrian Sevcenco, Guy Paic, Nelson Carlin Filho, Abdiel Ramirez Reyes, Joel Anthony Mazer, Francesca Bellini, M. Kalisky, Oleg Karavichev, B. Boyer, Boris Wagner, A. Michalon, Ingvar Otterlund, Chiara Bianchin, Marco H. D. van Leeuwen, Alexandru Florin Dobrin, C. Baumann, Malgorzata Anna Janik, A. Pulvirenti, B. H. Han, Roberto Divia, Csaba Soos, Do-Won Kim, Y. Vinogradov, David H. Evans, S. Porteboeuf-Houssais, Yvonne Chiara Pachmayer, Tatsuya Chujo, Christian Holm Christensen, Dario Berzano, Carlos Eugenio Perez Lara, Mohd Danish Azmi, Peter Malzacher, Cynthia Marie Hadjidakis, Martin Poghosyan, Trine Spedstad Tveter, Natalia Kondratyeva, Mateusz Andrzej Ploskon, Siegfried Valentin Foertsch, Gianluca Aglieri Rinella, Ivan Kisel, D. Peresunko, Filippo Costa, D. Tlusty, Oliver Busch, Marian Ivanov, Jens Wiechula, Kai Schweda, B. K. Srivastava, Filip Krizek, Ajay Kumar Dash, Alexander Mamonov, Fengchu Zhou, Vladimir Nikulin, Maria Haiduc, A. Ochirov, Ken Oyama, Claudio Geuna, Boris Hippolyte, Jean-Yves Grossiord, Andrei Ionut Herghelegiu, Heiko Engel, D. R. Gangadharan, C. Tagridis, Diego Stocco, E. Dénes, V. Demanov, Gian Michele Innocenti, Jogender Saini, Fedor Guber, Constantinos Loizides, Sven Gotovac, Zabulon Vilakazi, Arturo Alejandro Menchaca-Rocha, Marek Bombara, Andrea De Azevedo Moregula, Peter Strmen, Xianbao Yuan, Vladimir Vechernin, Dong Wang, Artur Krzysztof Szostak, Eva Sicking, Nicolas Arbor, Eugenio Nappi, Kristjan Herlache Gulbrandsen, M. R. Girard, Antonio Uras, Johannes Peter Wessels, G. Stefanek, Sidharth Kumar Prasad, Alexandru Bercuci, A. Piccotti, M. Kretz, Enrichetta Maria Fiore, Thomas Humanic, Ewa Gladysz-dziadus, Jan Rak, M. Wilde, A.G. Fedunov, Steffen Schreiner, Hideyuki Obayashi, M. E. Cotallo, Maria Vasileiou, V. Paticchio, Arnulfo Martinez Davalos, S. P. Jayarathna, Shiming Yang, Kalliopi Kanaki, Christoph Mayer, Kyrre Skjerdal, Emilia Cruz Alaniz, Sergey Filchagin, Stefan Rossegger, E. Montes, Ju Hwan Kang, F. Piuz, Shingo Sakai, Taesoo Kim, Peter Braun-Munzinger, Sanjeev Singh Sambyal, Kyoichiro Ozawa, Jean-Pierre Revol, HT Yang, J. Ulery, Philippe Rosnet, Fernando Baltasar Dos Santos Pedrosa, Eleazar Cuautle, Ralf Keidel, Alice Zimmermann, Sun Kun Oh, Y. Hori, Peter Levai, R. Bellwied, G. Stefanini, Gergely Gabor Barnafoldi, Beomkyu Kim, G. Puddu, Greeshma Koyithatta Meethaleveedu, Kathrin Koch, L. Riccati, S. Radomski, Sergey Kiselev, Yury Kharlov, Luciano Musa, Gennady Zinovjev, Sadhana Dash, Alejandro Szanto de Toledo, Dieter Røhrich, Mihaela Gheata, Gustavo Conesa Balbastre, T. Pawlak, K. Shtejer, Magnus Mager, W. J. Park, David Michael Rohr, F. Rettig, Marta Verweij, Pietro Antonioli, Maria Nicassio, W. Peryt, Federico Carminati, Krzysztof Redlich, A. Rachevski, Ismael Cortes Maldonado, I. Sgura, L. Vannucci, Jozef Urban, Marian Putis, Peter Martin Jacobs, Jon Christopher Wikne, Alessandro De Falco, T. Kalliokoski, Michal Petran, Ramni Gupta, D. Hatzifotiadou, R. Varma, Edith Zinhle Buthelezi, Fabio Filippo Colamaria, Laszlo Boldizsar, Paola Gianotti, Salvatore De Pasquale, Teodor Siemiarczuk, Giuseppe Simonetti, Vito Manzari, Haavard Helstrup, Crispin Williams, D. M. Madagodahettige-Don, Serhiy Senyukov, Ralf Peter Averbeck, Giacinto de Cataldo, Hans Peter Beck, Paola La Rocca, Edmundo Javier Garcia-Solis, Igor Lakomov, N. Zaviyalov, L. V. Malinina, Sergio Di Liberto, Bastian Bathen, R. Janik, Iouri Belikov, Thomas Dietel, Helmut Oskar Oeschler, Lijiao Liu, Roman Lietava, Henrik Qvigstad, Annalisa Mastroserio, Orlando Villalobos Baillie, Jan Fiete Grosse-Oetringhaus, G. D'Erasmo, Y. Martynov, Igor Altsybeev, Christoph Blume, Jiri Mares, D. Vranic, Vitaly Loginov, Won Woong Jung, Andrzej Rybicki, Ciprian Mihai Mitu, Laure Marie Massacrier, Emanuele Quercigh, Pascal Dupieux, Andrea Dainese, Sergey Fokin, Jiebin Luo, Michele Caselle, Torsten Alt, A. Wilk, Yongwook Baek, Kenneth Francis Read, Zaida Conesa del Valle, Jan Cepila, Podist Kurashvili, Dae Sung Hwang, Y. P. Viyogi, Rene Brun, L. H. González-Trueba, Giacomo Volpe, Mihir Ranjan Dutta Majumdar, Mikhail Ippolitov, Jacek Tomasz Otwinowski, M. R. Cosentino, Ankita Goswami, You Zhou, Claudiu Cornel Schiaua, Sandra Moretto, Andrea Danu, Guillaume Batigne, Xiaomei Li, Renu Bala, Silvia Arcelli, A. G. Agocs, Dariusz Czeslaw Miskowiec, Paolo Camerini, Sergey Voloshin, S. Beole, A. Vyushin, Peter Zahariev Hristov, Pier Giorgio Innocenti, M. Sukhorukov, P. G. Kuijer, Leonidas Xaplanteris Karampatsos, Wladyslaw Henryk Trzaska, Satyajit Jena, Maxime Guilbaud, Rosario Turrisi, D. Hasegan, Jørgen André Lien, M. Morando, Bruno Espagnon, Antoine Xavier Lardeux, A. Konevskih, Ramona Lea, Gabriel de Barros, Betty Abelev, Arian Abrahantes Quintana, Dagmar Adamova, Andrew Marshall Adare, Madan Aggarwal, Gianluca Aglieri Rinella, Andras Gabor Agoc, Andrea Agostinelli, Saul Aguilar Salazar, Zubayer Ahammed, Nazeer Ahmad, Arshad Ahmad, Sang Un Ahn, Alexander Akindinov, Dmitry Aleksandrov, Bruno Alessandro, Jose Ruben Alfaro Molina, Andrea Alici, Anton Alkin, Erick Jonathan Almaraz Avina, Torsten Alt, Valerio Altini, Sedat Altinpinar, Igor Altsybeev, Cristian Andrei, Anton Andronic, Venelin Anguelov, Christopher Daniel Anson, Tome Anticic, Federico Antinori, Pietro Antonioli, Laurent Bernard Aphecetche, Harald Appelshauser, Nicolas Arbor, Silvia Arcelli, Andreas Arend, Nestor Armesto, Roberta Arnaldi, Tomas Robert Aronsson, Ionut Cristian Arsene, Mesut Arslandok, Andzhey Asryan, Andre Augustinu, Ralf Peter Averbeck, Terry Awe, Juha Heikki Aysto, Mohd Danish Azmi, Matthias Jakob Bach, Angela Badala, Yong Wook Baek, Raphaelle Marie Bailhache, Renu Bala, Rinaldo Baldini Ferroli, Alberto Baldisseri, Alain Baldit, Fernando Baltasar Dos Santos Pedrosa, Jaroslav Ban, Rama Chandra Baral, Roberto Barbera, Francesco Barile, Gergely Gabor Barnafoldi, Lee Stuart Barnby, Valerie Barret, Jerzy Gustaw Bartke, Maurizio Basile, Nicole Bastid, Bastian Bathen, Guillaume Batigne, Boris Batyunya, Christoph Heinrich Baumann, Ian Gardner Bearden, Hans Beck, Iouri Belikov, Francesca Bellini, Rene Bellwied, Ernesto Belmont-Moreno, Stefania Beole, Ionela Berceanu, Alexandru Bercuci, Yaroslav Berdnikov, Daniel Berenyi, Cyrano Bergmann, Dario Berzano, Latchezar Betev, Anju Bhasin, Ashok Kumar Bhati, Nicola Bianchi, Livio Bianchi, Chiara Bianchin, Jaroslav Bielcik, Jana Bielcikova, Ante Bilandzic, F. Blanco, Francesco Blanco, Dmitry Blau, Christoph Blume, Marco Boccioli, Nicolas Bock, Alexey Bogdanov, Hans Boggild, Mikhail Bogolyubsky, Laszlo Boldizsar, Marek Bombara, Julian Book, Herve Borel, Alexander Borissov, Claudio Bortolin, Suvendu Nath Bose, Francesco Bossu, Michiel Botje, Stefan Bottger, Bruno Alexandre Boyer, Peter Braun-Munzinger, Marco Bregant, Timo Gunther Breitner, Michal Broz, Rene Brun, Elena Bruna, Giuseppe Eugenio Bruno, Dmitry Budnikov, Henner Buesching, Stefania Bufalino, Kyrylo Bugaiev, Oliver Busch, Edith Zinhle Buthelezi, Davide Caffarri, Xu Cai, Helen Louise Caine, Ernesto Calvo Villar, Paolo Camerini, Veronica Canoa Roman, Giovanni Cara Romeo, Francesco Carena, Wisla Carena, Nelson Carlin Filho, Federico Carminati, Camilo Andres Carrillo Montoya, Amaya Ofelia Casanova Diaz, Michele Caselle, Javier Ernesto Castillo Castellano, Juan Francisco Castillo Hernandez, Ester Anna Rita Casula, Vasile Catanescu, Costanza Cavicchioli, Jan Cepila, Piergiorgio Cerello, Beomsu Chang, Sylvain Chapeland, Jean-Luc Fernand Charvet, Sukalyan Chattopadhyay, Subhasis Chattopadhyay, Michael Gerard Cherney, Cvetan Cheshkov, Brigitte Cheyni, Emilio Chiavassa, Vasco Miguel Chibante Barroso, David Chinellato, Peter Chochula, Marek Chojnacki, Panagiotis Christakoglou, Christian Holm Christensen, Peter Christiansen, Tatsuya Chujo, Suh-Urk Chung, Corrado Cicalo, Luisa Cifarelli, Federico Cindolo, Jean Willy Andre Cleyman, Fabrizio Coccetti, Jean-Pierre Michel Coffin, Fabio Colamaria, Domenico Colella, Gustavo Conesa Balbastre, Zaida Conesa Valle, Paul Constantin, Giacomo Contin, Jesus Guillermo Contrera, Thomas Michael Cormier, Yasser Corrales Morale, Pietro Cortese, Ismael Cortes Maldonado, Mauro Rogerio Cosentino, Filippo Costa, Manuel Enrique Cotallo, Elisabetta Crescio, Philippe Crochet, Emilia Cruz Alaniz, Eleazar Cuautle, Leticia Cunqueiro, Andrea Dainese, Hans Hjersing Dalsgaard, Andrea Danu, Indranil Da, Kushal Da, Debasish Da, Ajay Kumar Dash, Sadhana Dash, Sudipan De, Andrea Azevedo Moregula, Gabriel Barro, Annalisa Caro, Giacinto Cataldo, Jan Cuveland, Alessandro Falco, Daniele Gruttola, Hugues Delagrange, Eduardo Castillo Sanchez, Andrzej Deloff, Vyacheslav Demanov, Nora Marco, Ervin Dene, Salvatore Pasquale, Airton Deppman, Ginevra D’Erasmo, Raoul Stefan Rooij, Domenico Bari, Thomas Dietel, Carmelo Giglio, Sergio Liberto, Antonio Mauro, Pasquale Nezza, Roberto Divia, Oeystein Djuvsland, Alexandru Florin Dobrin, Tadeusz Antoni Dobrowolski, Isabel Dominguez, Benjamin Donigu, Olja Dordic, Olga Driga, Anand Kumar Dubey, Laurent Ducroux, Pascal Dupieux, Mihir Ranjan Dutta Majumdar, A.K. Dutta Majumdar, Domenico Elia, David Philip Emschermann, Heiko Engel, Hege Austrheim Erdal, Bruno Espagnon, Magali Danielle Estienne, Shinichi Esumi, David Evan, Gyulnara Eyyubova, Daniela Fabri, Julien Faivre, Davide Falchieri, Alessandra Fantoni, Markus Fasel, Roger Worsley Fearick, Anatoly Fedunov, Dominik Fehlker, Linus Feldkamp, Daniel Felea, Grigory Feofilov, Arturo Fernandez Tellez, Alessandro Ferretti, Roberta Ferretti, Jan Figiel, Marcel Figueredo, Sergey Filchagin, Rosa Anna Fini, Dmitry Finogeev, Fiorella Fionda, Enrichetta Maria Fiore, Michele Flori, Siegfried Valentin Foertsch, Panagiota Foka, Sergey Fokin, Enrico Fragiacomo, Michail Fragkiadaki, Ulrich Michael Frankenfeld, Ulrich Fuch, Christophe Furget, Mario Fusco Girard, Jens Joergen Gaardhoje, Martino Gagliardi, Alberto Gago, Mauro Gallio, Dhevan Raja Gangadharan, Paraskevi Ganoti, Jose Garabato, Edmundo Garcia-Soli, Irakli Garishvili, Jochen Gerhard, Marie Germain, Claudio Geuna, Andrei George Gheata, Mihaela Gheata, Bruno Ghidini, Premomoy Ghosh, Paola Gianotti, Martin Robert Girard, Paolo Giubellino, Ewa Gladysz-Dziadu, Peter Glassel, Ramon Gomez, Elena Gonzalez Ferreiro, Laura Helena Gonzalez-Trueba, Pedro Gonzalez-Zamora, Sergey Gorbunov, Ankita Goswami, Sven Gotovac, Varlen Grabski, Lukasz Kamil Graczykowski, Robert Grajcarek, Alessandro Grelli, Costin Grigora, Alina Gabriela Grigora, Vladislav Grigoriev, Ara Grigoryan, Smbat Grigoryan, Boris Grinyov, Nevio Grion, Philippe Gro, Jan Fiete Grosse-Oetringhau, Jean-Yves Grossiord, Raffaele Grosso, Fedor Guber, Rachid Guernane, Cesar Guerra Gutierrez, Barbara Guerzoni, Maxime Rene Joseph Guilbaud, Kristjan Herlache Gulbrandsen, Taku Gunji, Anik Gupta, Ramni Gupta, Hans Gutbrod, Oystein Senneset Haaland, Cynthia Marie Hadjidaki, Maria Haiduc, Hideki Hamagaki, Gergoe Hamar, Byounghee Han, Luke David Hanratty, Alexander Hansen, Zuzana Harmanova, John William Harri, Matthias Hartig, Dumitru Hasegan, Despoina Hatzifotiadou, Arsen Hayrapetyan, Stefan Thomas Heckel, Markus Ansgar Heide, Haavard Helstrup, Andrei Ionut Herghelegiu, Gerardo Antonio Herrera Corral, Norbert Herrmann, Kristin Fanebust Hetland, Bernard Hick, Per Thomas Hille, Boris Hippolyte, Takuma Horaguchi, Yasuto Hori, Peter Zahariev Hristov, Ivana Hrivnacova, Meidana Huang, Sebastian Bernd Huber, Thomas Humanic, Dae Sung Hwang, Raphaelle Ichou, Radiy Ilkaev, Iryna Ilkiv, Motoi Inaba, Elisa Incani, Pier Giorgio Innocenti, Gian Michele Innocenti, Mikhail Ippolitov, Muhammad Irfan, Cristian George Ivan, Marian Ivanov, Vladimir Ivanov, Andrey Ivanov, Oleksii Ivanytskyi, Adam Wlodzimierz Jacholkowski, Peter Jacob, Lucia Jancurova, Haeng Jin Jang, Swensy Gwladys Jangal, Rudolf Janik, Malgorzata Anna Janik, Sandun Jayarathna, Satyajit Jena, Raul Tonatiuh Jimenez Bustamante, Lennart Jirden, Peter Graham Jone, Won Woong Jung, Hyung Taik Jung, Anton Jusko, Alexei Kaidalov, Vanik Kakoyan, Sebastian Kalcher, Peter Kalinak, Matus Kalisky, Tuomo Esa Aukusti Kalliokoski, Alexander Philipp Kalweit, Kalliopi Kanaki, Ju Hwan Kang, Vladimir Kaplin, Ayben Karasu Uysal, Oleg Karavichev, Tatiana Karavicheva, Evgeny Karpechev, Andrey Kazantsev, Udo Wolfgang Kebschull, Ralf Keidel, Palash Khan, Mohisin Mohammed Khan, Shuaib Ahmad Khan, Alexei Khanzadeev, Yury Kharlov, Bjarte Kileng, Jonghyun Kim, Dong Jo Kim, Do Won Kim, Jin Sook Kim, Minwoo Kim, Seon Hee Kim, Se Yong Kim, Beomkyu Kim, Taesoo Kim, Stefan Kirsch, Ivan Kisel, Sergey Kiselev, Adam Ryszard Kisiel, Jennifer Lynn Klay, Jochen Klein, Christian Klein-Bosing, Michael Kliemant, Alexander Kluge, Michael Linus Knichel, Kathrin Koch, Markus Kohler, Anatoly Kolojvari, Valery Kondratiev, Natalia Kondratyeva, Artem Konevskih, Andrey Korneev, Chamath Kottachchi Kankanamge Don, Ravjeet Kour, Marek Kowalski, Serge Kox, Greeshma Koyithatta Meethaleveedu, Jiri Kral, Ivan Kralik, Frederick Kramer, Ingrid Christine Krau, Tobias Krawutschke, Matthias Kretz, Marian Krivda, Filip Krizek, Miroslav Kru, Evgeny Kryshen, Mikolaj Krzewicki, Yury Kucheriaev, Christian Claude Kuhn, Paul Kuijer, Podist Kurashvili, A.B. Kurepin, A. Kurepin, Alexey Kuryakin, Svetlana Kushpil, Vasily Kushpil, Henning Kvaerno, Min Jung Kweon, Youngil Kwon, Pedro Ladron Guevara, Igor Lakomov, Rune Langoy, Camilo Ernesto Lara, Antoine Xavier Lardeux, Paola Rocca, Cristina Lazzeroni, Ramona Lea, Yves Bornec, Sung Chul Lee, Ki Sang Lee, Frederic Lefevre, Joerg Walter Lehnert, Lars Leistam, Matthieu Laurent Lenhardt, Vito Lenti, Hermes Leon, Ildefonso Leon Monzon, Hermes Leon Varga, Peter Levai, Xiaomei Li, Jorgen Lien, Roman Lietava, Svein Lindal, Volker Lindenstruth, Christian Lippmann, Michael Annan Lisa, Lijiao Liu, Per-Ivar Loenne, Vera Loggin, Vitaly Loginov, Stefan Bernhard Lohn, Daniel Lohner, Constantinos Loizide, Kai Krister Loo, Xavier Bernard Lopez, Ernesto Lopez Torre, Gunnar Lovhoiden, Xianguo Lu, Philipp Luettig, Marcello Lunardon, Jiebin Luo, Grazia Luparello, Lionel Luquin, Cinzia Luzzi, Rongrong Ma, Ke Ma, Dilan Minthaka Madagodahettige-Don, Alla Maevskaya, Magnus Mager, Durga Prasad Mahapatra, Antonin Maire, Mikhail Malaev, Ivonne Alicia Maldonado Cervante, Ludmila Malinina, Dmitry Mal’Kevich, Peter Malzacher, Alexander Mamonov, Loic Henri Antoine Manceau, Lalit Kumar Mangotra, Vladislav Manko, Franck Manso, Vito Manzari, Yaxian Mao, Massimiliano Marchisone, Jiri Mare, Giacomo Vito Margagliotti, Anselmo Margotti, Ana Maria Marin, Christina Markert, Irakli Martashvili, Paolo Martinengo, Mario Ivan Martinez, Arnulfo Martinez Davalo, Gines Martinez Garcia, Yevgen Martynov, Alexis Jean-Michel Ma, Silvia Masciocchi, Massimo Masera, Alberto Masoni, Laure Marie Massacrier, Mario Mastromarco, Annalisa Mastroserio, Zoe Louise Matthew, Adam Tomasz Matyja, Daniel Mayani, Christoph Mayer, Joel Mazer, Alessandra Maria Mazzoni, Franco Meddi, Arturo Alejandro Menchaca-Rocha, Jorge Mercado Perez, Michal Mere, Yasuo Miake, Alain Michalon, Jumpei Midori, Leonardo Milano, Jovan Milosevic, Andre Mischke, Aditya Nath Mishra, Dariusz Miskowiec, Ciprian Mihai Mitu, Jocelyn Mlynarz, Ajit Kumar Mohanty, Bedangadas Mohanty, Levente Molnar, Luis Manuel Montano Zetina, Marco Monteno, Esther Monte, Taebong Moon, Maurizio Morando, Denise Aparecida Moreira Godoy, Sandra Moretto, Andreas Morsch, Valeria Muccifora, Eugen Mudnic, Sanjib Muhuri, Hans Muller, Marcelo Munhoz, Luciano Musa, Alfredo Musso, Basanta Kumar Nandi, Rosario Nania, Eugenio Nappi, Christine Nattra, Nikolay Naumov, Sparsh Navin, Tapan Kumar Nayak, Sergey Nazarenko, Gleb Nazarov, Alexander Nedosekin, Maria Nicassio, Borge Svane Nielsen, Takafumi Niida, Sergey Nikolaev, Vedran Nikolic, Vladimir Nikulin, Sergey Nikulin, Bjorn Steven Nilsen, Mads Stormo Nilsson, Francesco Noferini, Petr Nomokonov, Gerardus Nooren, Norbert Novitzky, Alexandre Nyanin, Anitha Nyatha, Casper Nygaard, Joakim Ingemar Nystrand, Hideyuki Obayashi, Alexander Ochirov, Helmut Oskar Oeschler, Sun Kun Oh, Saehanseul Oh, Janusz Oleniacz, Chiara Oppedisano, Antonio Ortiz Velasquez, Giacomo Ortona, Anders Nils Erik Oskarsson, Piotr Krystian Ostrowski, Ingvar Otterlund, Jacek Tomasz Otwinowski, Ken Oyama, Kyoichiro Ozawa, Yvonne Chiara Pachmayer, Milos Pachr, Fatima Padilla, Paola Pagano, Guy Paic, Florian Painke, Carlos Pajare, S. 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Zimmermann, Gennady Zinovjev, Yannick Denis Zoccarato, Mykhaylo Zynovyev, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche 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Scientifique (CNRS), Laboratoire de Physique Corpusculaire, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), ALICE Collaboration (ukupan broj autora: 971), Betty, Abelev, Arian Abrahantes, Quintana, Dagmar, Adamova, Andrew Marshall, Adare, Madan, Aggarwal, Gianluca Aglieri, Rinella, Andras Gabor, Agoc, Andrea, Agostinelli, Saul Aguilar, Salazar, Zubayer, Ahammed, Nazeer, Ahmad, Arshad, Ahmad, Sang Un, Ahn, Alexander, Akindinov, Dmitry, Aleksandrov, Bruno, Alessandro, Jose Ruben Alfaro, Molina, Andrea, Alici, Anton, Alkin, Erick Jonathan Almaraz, Avina, Torsten, Alt, Valerio, Altini, Sedat, Altinpinar, Igor, Altsybeev, Cristian, Andrei, Anton, Andronic, Venelin, Anguelov, Christopher Daniel, Anson, Tome, Anticic, Federico, Antinori, Pietro, Antonioli, Laurent Bernard, Aphecetche, Harald, Appelshauser, Nicolas, Arbor, Silvia, Arcelli, Andreas, Arend, Nestor, Armesto, Roberta, Arnaldi, Tomas Robert, Aronsson, Ionut Cristian, Arsene, Mesut, Arslandok, Andzhey, Asryan, Andre, Augustinu, Ralf Peter, Averbeck, Terry, Awe, Juha Heikki, Aysto, Mohd Danish, Azmi, Matthias Jakob, Bach, Angela, Badala, Yong Wook, Baek, Raphaelle Marie, Bailhache, Renu, Bala, Rinaldo Baldini, Ferroli, Alberto, Baldisseri, Alain, Baldit, Fernando Baltasar Dos Santos, Pedrosa, Jaroslav, Ban, Rama Chandra, Baral, Roberto, Barbera, Francesco, Barile, Gergely Gabor, Barnafoldi, Lee Stuart, Barnby, Valerie, Barret, Jerzy Gustaw, Bartke, Maurizio, Basile, Nicole, Bastid, Bastian, Bathen, Guillaume, Batigne, Boris, Batyunya, Christoph Heinrich, Baumann, Ian Gardner, Bearden, Hans, Beck, Iouri, Belikov, Francesca, Bellini, Rene, Bellwied, Ernesto Belmont, Moreno, Stefania, Beole, Ionela, Berceanu, Alexandru, Bercuci, Yaroslav, Berdnikov, Daniel, Berenyi, Cyrano, Bergmann, Dario, Berzano, Latchezar, Betev, Anju, Bhasin, Ashok Kumar, Bhati, Nicola, Bianchi, Livio, Bianchi, Chiara, Bianchin, Jaroslav, Bielcik, Jana, Bielcikova, Ante, Bilandzic, F., Blanco, Francesco, Blanco, Dmitry, Blau, Christoph, Blume, Marco, Boccioli, Nicolas, Bock, Alexey, Bogdanov, Hans, Boggild, Mikhail, Bogolyubsky, Laszlo, Boldizsar, Marek, Bombara, Julian, Book, Herve, Borel, Alexander, Borissov, Claudio, Bortolin, Suvendu Nath, Bose, Francesco, Bossu, Michiel, Botje, Stefan, Bottger, Bruno Alexandre, Boyer, Peter Braun, Munzinger, Bregant, Marco, Timo Gunther, Breitner, Michal, Broz, Rene, Brun, Elena, Bruna, Giuseppe Eugenio, Bruno, Dmitry, Budnikov, Henner, Buesching, Stefania, Bufalino, Kyrylo, Bugaiev, Oliver, Busch, Edith Zinhle, Buthelezi, Davide, Caffarri, Xu, Cai, Helen Louise, Caine, Ernesto Calvo, Villar, Camerini, Paolo, Veronica Canoa, Roman, Giovanni Cara, Romeo, Francesco, Carena, Wisla, Carena, Nelson Carlin, Filho, Federico, Carminati, Camilo Andres Carrillo, Montoya, Amaya Ofelia Casanova, Diaz, Michele, Caselle, Javier Ernesto Castillo, Castellano, Juan Francisco Castillo, Hernandez, Ester Anna Rita, Casula, Vasile, Catanescu, Costanza, Cavicchioli, Jan, Cepila, Piergiorgio, Cerello, Beomsu, Chang, Sylvain, Chapeland, Jean Luc Fernand, Charvet, Sukalyan, Chattopadhyay, Subhasis, Chattopadhyay, Michael Gerard, Cherney, Cvetan, Cheshkov, Brigitte, Cheyni, Emilio, Chiavassa, Vasco Miguel Chibante, Barroso, David, Chinellato, Peter, Chochula, Marek, Chojnacki, Panagiotis, Christakoglou, Christian Holm, Christensen, Peter, Christiansen, Tatsuya, Chujo, Suh Urk, Chung, Corrado, Cicalo, Luisa, Cifarelli, Federico, Cindolo, Jean Willy Andre, Cleyman, Fabrizio, Coccetti, Jean Pierre Michel, Coffin, Fabio, Colamaria, Domenico, Colella, Gustavo Conesa, Balbastre, Zaida Conesa, Valle, Paul, Constantin, Contin, Giacomo, Jesus Guillermo, Contrera, Thomas Michael, Cormier, Yasser Corrales, Morale, Pietro, Cortese, Ismael Cortes, Maldonado, Mauro Rogerio, Cosentino, Filippo, Costa, Manuel Enrique, Cotallo, Elisabetta, Crescio, Philippe, Crochet, Emilia Cruz, Alaniz, Eleazar, Cuautle, Leticia, Cunqueiro, Andrea, Dainese, Hans Hjersing, Dalsgaard, Andrea, Danu, Indranil, Da, Kushal, Da, Debasish, Da, Ajay Kumar, Dash, Sadhana, Dash, Sudipan, De, Andrea Azevedo, Moregula, Gabriel, Barro, Annalisa, Caro, Giacinto, Cataldo, Jan, Cuveland, Alessandro, Falco, Daniele, Gruttola, Hugues, Delagrange, Eduardo Castillo, Sanchez, Andrzej, Deloff, Vyacheslav, Demanov, Nora, Marco, Ervin, Dene, Salvatore, Pasquale, Airton, Deppman, Ginevra, D’Erasmo, Raoul Stefan, Rooij, Domenico, Bari, Thomas, Dietel, Carmelo, Giglio, Sergio, Liberto, Antonio, Mauro, Pasquale, Nezza, Roberto, Divia, Oeystein, Djuvsland, Alexandru Florin, Dobrin, Tadeusz Antoni, Dobrowolski, Isabel, Dominguez, Benjamin, Donigu, Olja, Dordic, Olga, Driga, Anand Kumar, Dubey, Laurent, Ducroux, Pascal, Dupieux, Mihir Ranjan Dutta, Majumdar, A. K., Dutta Majumdar, Domenico, Elia, David Philip, Emschermann, Heiko, Engel, Hege Austrheim, Erdal, Bruno, Espagnon, Magali Danielle, Estienne, Shinichi, Esumi, David, Evan, Gyulnara, Eyyubova, Daniela, Fabri, Julien, Faivre, Davide, Falchieri, Alessandra, Fantoni, Markus, Fasel, Roger Worsley, Fearick, Anatoly, Fedunov, Dominik, Fehlker, Linus, Feldkamp, Daniel, Felea, Grigory, Feofilov, Arturo Fernandez, Tellez, Alessandro, Ferretti, Roberta, Ferretti, Jan, Figiel, Marcel, Figueredo, Sergey, Filchagin, Rosa Anna, Fini, Dmitry, Finogeev, Fiorella, Fionda, Enrichetta Maria, Fiore, Michele, Flori, Siegfried Valentin, Foertsch, Panagiota, Foka, Sergey, Fokin, Fragiacomo, Enrico, Michail, Fragkiadaki, Ulrich Michael, Frankenfeld, Ulrich, Fuch, Christophe, Furget, Mario Fusco, Girard, Jens Joergen, Gaardhoje, Martino, Gagliardi, Alberto, Gago, Mauro, Gallio, Dhevan Raja, Gangadharan, Paraskevi, Ganoti, Jose, Garabato, Edmundo Garcia, Soli, Irakli, Garishvili, Jochen, Gerhard, Marie, Germain, Claudio, Geuna, Andrei George, Gheata, Mihaela, Gheata, Bruno, Ghidini, Premomoy, Ghosh, Paola, Gianotti, Martin Robert, Girard, Paolo, Giubellino, Ewa Gladysz, Dziadu, Peter, Glassel, Ramon, Gomez, Elena Gonzalez, Ferreiro, Laura Helena Gonzalez, Trueba, Pedro Gonzalez, Zamora, Sergey, Gorbunov, Ankita, Goswami, Sven, Gotovac, Varlen, Grabski, Lukasz Kamil, Graczykowski, Robert, Grajcarek, Alessandro, Grelli, Costin, Grigora, Alina Gabriela, Grigora, Vladislav, Grigoriev, Ara, Grigoryan, Smbat, Grigoryan, Boris, Grinyov, Nevio, Grion, Philippe, Gro, Jan Fiete Grosse, Oetringhau, Jean Yves, Grossiord, Grosso, Raffaele, Fedor, Guber, Rachid, Guernane, Cesar Guerra, Gutierrez, Barbara, Guerzoni, Maxime Rene Joseph, Guilbaud, Kristjan Herlache, Gulbrandsen, Taku, Gunji, Anik, Gupta, Ramni, Gupta, Hans, Gutbrod, Oystein Senneset, Haaland, Cynthia Marie, Hadjidaki, Maria, Haiduc, Hideki, Hamagaki, Gergoe, Hamar, Byounghee, Han, Luke David, Hanratty, Alexander, Hansen, Zuzana, Harmanova, John William, Harri, Matthias, Hartig, Dumitru, Hasegan, Despoina, Hatzifotiadou, Arsen, Hayrapetyan, Stefan Thomas, Heckel, Markus Ansgar, Heide, Haavard, Helstrup, Andrei Ionut, Herghelegiu, Gerardo Antonio Herrera, Corral, Norbert, Herrmann, Kristin Fanebust, Hetland, Bernard, Hick, Per Thomas, Hille, Boris, Hippolyte, Takuma, Horaguchi, Yasuto, Hori, Peter Zahariev, Hristov, Ivana, Hrivnacova, Meidana, Huang, Sebastian Bernd, Huber, Thomas, Humanic, Dae Sung, Hwang, Raphaelle, Ichou, Radiy, Ilkaev, Iryna, Ilkiv, Motoi, Inaba, Elisa, Incani, Pier Giorgio, Innocenti, Gian Michele, Innocenti, Mikhail, Ippolitov, Muhammad, Irfan, Cristian George, Ivan, Marian, Ivanov, Vladimir, Ivanov, Andrey, Ivanov, Oleksii, Ivanytskyi, Adam Wlodzimierz, Jacholkowski, Peter, Jacob, Lucia, Jancurova, Haeng Jin, Jang, Swensy Gwladys, Jangal, Rudolf, Janik, Malgorzata Anna, Janik, Sandun, Jayarathna, Satyajit, Jena, Raul Tonatiuh Jimenez, Bustamante, Lennart, Jirden, Peter Graham, Jone, Won Woong, Jung, Hyung Taik, Jung, Anton, Jusko, Alexei, Kaidalov, Vanik, Kakoyan, Sebastian, Kalcher, Peter, Kalinak, Matus, Kalisky, Tuomo Esa Aukusti, Kalliokoski, Alexander Philipp, Kalweit, Kalliopi, Kanaki, Ju Hwan, Kang, Vladimir, Kaplin, Ayben Karasu, Uysal, Oleg, Karavichev, Tatiana, Karavicheva, Evgeny, Karpechev, Andrey, Kazantsev, Udo Wolfgang, Kebschull, Ralf, Keidel, Palash, Khan, Mohisin Mohammed, Khan, Shuaib Ahmad, Khan, Alexei, Khanzadeev, Yury, Kharlov, Bjarte, Kileng, Jonghyun, Kim, Dong Jo, Kim, Do Won, Kim, Jin Sook, Kim, Minwoo, Kim, Seon Hee, Kim, Se Yong, Kim, Beomkyu, Kim, Taesoo, Kim, Stefan, Kirsch, Ivan, Kisel, Sergey, Kiselev, Adam Ryszard, Kisiel, Jennifer Lynn, Klay, Jochen, Klein, Christian Klein, Bosing, Michael, Kliemant, Alexander, Kluge, Michael Linus, Knichel, Kathrin, Koch, Markus, Kohler, Anatoly, Kolojvari, Valery, Kondratiev, Natalia, Kondratyeva, Artem, Konevskih, Andrey, Korneev, Chamath Kottachchi Kankanamge, Don, Ravjeet, Kour, Marek, Kowalski, Serge, Kox, Greeshma Koyithatta, Meethaleveedu, Jiri, Kral, Ivan, Kralik, Frederick, Kramer, Ingrid Christine, Krau, Tobias, Krawutschke, Matthias, Kretz, Marian, Krivda, Filip, Krizek, Miroslav, Kru, Evgeny, Kryshen, Mikolaj, Krzewicki, Yury, Kucheriaev, Christian Claude, Kuhn, Paul, Kuijer, Podist, Kurashvili, A. B., Kurepin, A., Kurepin, Alexey, Kuryakin, Svetlana, Kushpil, Vasily, Kushpil, Henning, Kvaerno, Min Jung, Kweon, Youngil, Kwon, Pedro Ladron, Guevara, Igor, Lakomov, Rune, Langoy, Camilo Ernesto, Lara, Antoine Xavier, Lardeux, Paola, Rocca, Cristina, Lazzeroni, Lea, Ramona, Yves, Bornec, Sung Chul, Lee, Ki Sang, Lee, Frederic, Lefevre, Joerg Walter, Lehnert, Lars, Leistam, Matthieu Laurent, Lenhardt, Vito, Lenti, Hermes, Leon, Ildefonso Leon, Monzon, Hermes Leon, Varga, Peter, Levai, Xiaomei, Li, Jorgen, Lien, Roman, Lietava, Svein, Lindal, Volker, Lindenstruth, Christian, Lippmann, Michael Annan, Lisa, Lijiao, Liu, Per Ivar, Loenne, Vera, Loggin, Vitaly, Loginov, Stefan Bernhard, Lohn, Daniel, Lohner, Constantinos, Loizide, Kai Krister, Loo, Xavier Bernard, Lopez, Ernesto Lopez, Torre, Gunnar, Lovhoiden, Xianguo, Lu, Philipp, Luettig, Marcello, Lunardon, Jiebin, Luo, Grazia, Luparello, Lionel, Luquin, Cinzia, Luzzi, Rongrong, Ma, Ke, Ma, Dilan Minthaka Madagodahettige, Don, Alla, Maevskaya, Magnus, Mager, Durga Prasad, Mahapatra, Antonin, Maire, Mikhail, Malaev, Ivonne Alicia Maldonado, Cervante, Ludmila, Malinina, Dmitry, Mal’Kevich, Peter, Malzacher, Alexander, Mamonov, Loic Henri Antoine, Manceau, Lalit Kumar, Mangotra, Vladislav, Manko, Franck, Manso, Vito, Manzari, Yaxian, Mao, Massimiliano, Marchisone, Jiri, Mare, Margagliotti, Giacomo, Anselmo, Margotti, Ana Maria, Marin, Christina, Markert, Irakli, Martashvili, Paolo, Martinengo, Mario Ivan, Martinez, Arnulfo Martinez, Davalo, Gines Martinez, Garcia, Yevgen, Martynov, Alexis Jean Michel, Ma, Silvia, Masciocchi, Massimo, Masera, Alberto, Masoni, Laure Marie, Massacrier, Mario, Mastromarco, Annalisa, Mastroserio, Zoe Louise, Matthew, Adam Tomasz, Matyja, Daniel, Mayani, Christoph, Mayer, Joel, Mazer, Alessandra Maria, Mazzoni, Franco, Meddi, Arturo Alejandro Menchaca, Rocha, Jorge Mercado, Perez, Michal, Mere, Yasuo, Miake, Alain, Michalon, Jumpei, Midori, Leonardo, Milano, Jovan, Milosevic, Andre, Mischke, Aditya Nath, Mishra, Dariusz, Miskowiec, Ciprian Mihai, Mitu, Jocelyn, Mlynarz, Ajit Kumar, Mohanty, Bedangadas, Mohanty, Levente, Molnar, Luis Manuel Montano, Zetina, Marco, Monteno, Esther, Monte, Taebong, Moon, Maurizio, Morando, Denise Aparecida Moreira, Godoy, Sandra, Moretto, Andreas, Morsch, Valeria, Muccifora, Eugen, Mudnic, Sanjib, Muhuri, Hans, Muller, Marcelo, Munhoz, Luciano, Musa, Alfredo, Musso, Basanta Kumar, Nandi, Rosario, Nania, Eugenio, Nappi, Christine, Nattra, Nikolay, Naumov, Sparsh, Navin, Tapan Kumar, Nayak, Sergey, Nazarenko, Gleb, Nazarov, Alexander, Nedosekin, Maria, Nicassio, Borge Svane, Nielsen, Takafumi, Niida, Sergey, Nikolaev, Vedran, Nikolic, Vladimir, Nikulin, Sergey, Nikulin, Bjorn Steven, Nilsen, Mads Stormo, Nilsson, Francesco, Noferini, Petr, Nomokonov, Gerardus, Nooren, Norbert, Novitzky, Alexandre, Nyanin, Anitha, Nyatha, Casper, Nygaard, Joakim Ingemar, Nystrand, Hideyuki, Obayashi, Alexander, Ochirov, Helmut Oskar, Oeschler, Sun Kun, Oh, Saehanseul, Oh, Janusz, Oleniacz, Chiara, Oppedisano, Antonio Ortiz, Velasquez, Giacomo, Ortona, Anders Nils Erik, Oskarsson, Piotr Krystian, Ostrowski, Ingvar, Otterlund, Jacek Tomasz, Otwinowski, Ken, Oyama, Kyoichiro, Ozawa, Yvonne Chiara, Pachmayer, Milos, Pachr, Fatima, Padilla, Paola, Pagano, Guy, Paic, Florian, Painke, Carlos, Pajare, S., Pal, Susanta Kumar, Pal, Arvinder Singh, Palaha, Armando, Palmeri, Vardanush, Papikyan, Giuseppe, Pappalardo, Woo Jin, Park, Annika, Passfeld, Blahoslav, Pastircak, Dmitri Ivanovich, Patalakha, Vincenzo, Paticchio, Alexei, Pavlinov, Tomasz Jan, Pawlak, Thomas, Peitzmann, Marianela, Perale, Elienos Pereira Oliveira, Filho, Dmitri, Peresunko, Carlos Eugenio Perez, Lara, Edgar Perez, Lezama, Diego, Perini, Davide, Perrino, Wiktor Stanislaw, Peryt, Alessandro, Pesci, Vladimir, Peskov, Yury, Pestov, Vojtech, Petracek, Michal, Petran, Mariana, Petri, Plamen Rumenov, Petrov, Mihai, Petrovici, Catia, Petta, Piano, Stefano, Anna, Piccotti, Miroslav, Pikna, Philippe, Pillot, Ombretta, Pinazza, Lawrence, Pinsky, Nora, Pitz, Francois, Piuz, Danthasinghe, Piyarathna, Mateusz Andrzej, Ploskon, Jan Marian, Pluta, Timur, Pocheptsov, Sona, Pochybova, Pedro Luis Manuel Podesta, Lerma, Martin, Poghosyan, Karel, Polak, Boris, Polichtchouk, Amalia, Pop, Sarah Porteboeuf, Houssai, Vladimir, Pospisil, Baba, Potukuchi, Sidharth Kumar, Prasad, Roberto, Preghenella, Francesco, Prino, Claude Andre, Pruneau, Igor, Pshenichnov, Sergey, Puchagin, Giovanna, Puddu, Alberto, Pulvirenti, Valery, Punin, Marian, Puti, Jorn Henning, Putschke, Emanuele, Quercigh, Henrik, Qvigstad, Alexandre, Rachevski, Alphonse, Rademaker, Sylwester, Radomski, Tomi Samuli, Raiha, Jan, Rak, Andry Malala, Rakotozafindrabe, Luciano, Ramello, Abdiel Ramirez, Reye, Sudhir, Raniwala, Rashmi, Raniwala, Sami Sakari, Rasanen, Bogdan Theodor, Rascanu, Deepika, Rathee, Kenneth Francis, Read, Jean Sebastien, Real, Krzysztof, Redlich, Patrick, Reichelt, Martijn, Reicher, Rainer Arno Ernst, Renfordt, Anna Rita, Reolon, Andrey, Reshetin, Felix Vincenz, Rettig, Jean Pierre, Revol, Klaus Johannes, Reyger, Lodovico, Riccati, Renato Angelo, Ricci, Matthias Rudolph, Richter, Petra, Riedler, Werner, Riegler, Francesco, Riggi, Mario Rodriguez, Cahuantzi, David, Rohr, Dieter, Rohrich, Rosa, Romita, Federico, Ronchetti, Philippe, Rosnet, Stefan, Rossegger, Andrea, Rossi, Filimon, Roukoutaki, Pradip Kumar, Roy, Christelle Sophie, Roy, Antonio Juan Rubio, Montero, Rui, Rinaldo, Evgeny, Ryabinkin, Andrzej, Rybicki, Sergey, Sadovsky, Karel, Safarik, Pradip Kumar, Sahu, Jogender, Saini, Hiroaki, Sakaguchi, Shingo, Sakai, Dosatsu, Sakata, Carlos Albert, Salgado, Sanjeev Singh, Sambyal, Vladimir, Samsonov, Xitzel Sanchez, Castro, Ladislav, Sandor, Andres, Sandoval, Masato, Sano, Satoshi, Sano, Rainer, Santo, Romualdo, Santoro, Juho Jaako, Sarkamo, Eugenio, Scapparone, Fernando, Scarlassara, Rolf Paul, Scharenberg, Claudiu Cornel, Schiaua, Rainer Martin, Schicker, Christian Joachim, Schmidt, Hans Rudolf, Schmidt, Steffen, Schreiner, Simone, Schuchmann, Jurgen, Schukraft, Yves Roland, Schutz, Kilian Eberhard, Schwarz, Kai Oliver, Schweda, Gilda, Scioli, Enrico, Scomparin, Rebecca, Scott, Patrick Aaron, Scott, Gianfranco, Segato, Ilya, Selioujenkov, Serhiy, Senyukov, Jeewon, Seo, Sergio, Serci, Eulogio, Serradilla, Adrian, Sevcenco, Irene, Sgura, Alexandre, Shabetai, Galina, Shabratova, Ruben, Shahoyan, Natasha, Sharma, Satish, Sharma, Kenta, Shigaki, Maya, Shimomura, Katherin, Shtejer, Yury, Sibiriak, Melinda, Siciliano, Eva, Sicking, Sabyasachi, Siddhanta, Teodor, Siemiarczuk, David Olle Rickard, Silvermyr, Giuseppe, Simonetti, Rama Narayana, Singaraju, Ranbir, Singh, Subhash, Singha, Bikash, Sinha, Tinku, Sinha, Branislav, Sitar, Mario, Sitta, Bernhard, Skaali, Kyrre, Skjerdal, Radek, Smakal, Nikolai, Smirnov, Raimond, Snelling, Carsten, Sogaard, Ron Ariel, Soltz, Hyungsuk, Son, Jihye, Song, Myunggeun, Song, Csaba, Soo, Francesca, Soramel, Iwona, Sputowska, Martha Spyropoulou, Stassinaki, Brijesh Kumar, Srivastava, Johanna, Stachel, Ionel, Stan, Grzegorz, Stefanek, Giorgio, Stefanini, Timm Morten, Steinbeck, Matthew, Steinprei, Evert Anders, Stenlund, Gideon Francois, Steyn, Diego, Stocco, Mikhail, Stolpovskiy, Kirill, Strabykin, Peter, Strmen, Alexandre Alarcon Passo, Suaide, Martin Alfonso Subieta, Vasquez, Toru, Sugitate, Christophe Pierre, Suire, Mikhail, Sukhorukov, Rishat, Sultanov, Michal, Sumbera, Tatjana, Susa, Alejandro Szanto, Toledo, Imrich, Szarka, Artur Krzysztof, Szostak, Christos, Tagridi, Jun, Takahashi, Daniel Jesus Tapia, Takaki, Arturo, Tauro, Guillermo Tejeda, Munoz, Adriana, Telesca, Cristina, Terrevoli, Jochen Mathias, Thader, Jim, Thoma, Deepa, Thoma, Raphael Noel, Tieulent, Anthony, Timmin, David, Tlusty, Alberica, Toia, Hisayuki, Torii, Luca, Toscano, Flavio, Tosello, Tomasz, Traczyk, David Christopher, Truesdale, Wladyslaw Henryk, Trzaska, Tomoya, Tsuji, Alexandr, Tumkin, Rosario, Turrisi, Trine Spedstad, Tveter, Jason Glyndwr, Ulery, Kjetil, Ullaland, Jochen, Ulrich, Antonio, Ura, Jozef, Urban, Guido Marie, Urciuoli, Gianluca, Usai, Michal, Vajzer, Martin, Vala, Lizardo Valencia, Palomo, Sara, Vallero, Naomi, Kolk, Pierre Vande, Vyvre, Marco, Leeuwen, Luigi, Vannucci, Aurora Diozcora, Varga, Raghava, Varma, Maria, Vasileiou, Andrey, Vasiliev, Vladimir, Vechernin, Misha, Veldhoen, Venaruzzo, Massimo, Ermanno, Vercellin, Sergio, Vergara, Don Constantin, Vernekohl, Renaud, Vernet, Marta, Verweij, Linda, Vickovic, Giuseppe, Viesti, Oleg, Vikhlyantsev, Zabulon, Vilakazi, Orlando Villalobos, Baillie, Leonid, Vinogradov, Yury, Vinogradov, Alexander, Vinogradov, Tiziano, Virgili, Yogendra, Viyogi, Alexander, Vodopianov, Sergey, Voloshin, Kirill, Voloshin, Giacomo, Volpe, Barthelemy, Haller, Danilo, Vranic, Gaute, Vrebekk, Janka, Vrlakova, Bogdan, Vulpescu, Alexey, Vyushin, Boris, Wagner, Vladimir, Wagner, Renzhuo, Wan, Yifei, Wang, Mengliang, Wang, Dong, Wang, Yaping, Wang, Kengo, Watanabe, Johannes, Wessel, Uwe, Westerhoff, Jens, Wiechula, Jon, Wikne, Martin Rudolf, Wilde, Grzegorz Andrzej, Wilk, Alexander, Wilk, Crispin, William, Bernd Stefan, Windelband, Leonidas Xaplanteris, Karampatso, Hongyan, Yang, Shiming, Yang, Satoshi, Yano, Stanislav, Yasnopolsky, Jungyu, Yi, Zhongbao, Yin, Hiroki, Yokoyama, In Kwon, Yoo, Jongik, Yoon, Weilin, Yu, Xianbao, Yuan, Igor, Yushmanov, Cenek, Zach, Chiara, Zampolli, Sergey, Zaporozhet, Andrey, Zarochentsev, Petr, Zavada, Nikolai, Zaviyalov, Hanna Paulina, Zbroszczyk, Pierre, Zelnicek, Sorin Ion, Zgura, Mikhail, Zhalov, Xiaoming, Zhang, Fengchu, Zhou, You, Zhou, Daicui, Zhou, Xiangrong, Zhu, Antonino, Zichichi, Alice, Zimmermann, Gennady, Zinovjev, Yannick Denis, Zoccarato, and Mykhaylo, Zynovyev
Subjects: Nuclear and High Energy Physics, Particle physics, Hadron, FOS: Physical sciences, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), model, hadron-hadron scattering, physics, proton-proton collisions, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Multiplicity (chemistry), 010306 general physics, Nuclear Experiment, Physics, Hadron-Hadron Scattering, PROTON-PROTON COLLISIONS, Underlying Event, Large Hadron Collider, ta114, 010308 nuclear & particles physics, ALICE experiment, Observable, ALICE, LHC, CERN, pp, 0.9 TeV, 7 TeV, Collision, Charged particle, P-P collision, Azimuth, Transverse plane, Hadron-hadron scattering, High Energy Physics::Experiment, Particle Physics - Experiment
Abstract: We present measurements of Underlying Event observables in pp collisions at $\sqrt{s}$ = 0.9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum $p_{\rm T, LT}$ in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different $p_{\rm T}$ thresholds: 0.15, 0.5 and 1.0 GeV/$c$. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track $p){\rm T}$ threshold considered. Data are compared to Pythia 6.4, Pythia 8.1 and Phojet. On average, all models considered underestimate the multiplicity and summed $p_{\rm T}$ in the Transverse region by about 10-30%., Comment: 36 pages, 22 captioned figures, 8 tables, authors from page 31, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/3099
Published: 2012
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46. Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques

Author: Giuseppe Pappalardo, Maria Anna Campitiello, Gaetano Malgieri, Carla Isernia, Luca Raiola, Luigi Russo, Diego La Mendola, A Magrì, Roberto Fattorusso, Russo, Luigi, Raiola, L, Campitiello, Ma, Magrì, A, Fattorusso, Roberto, Malgieri, Gaetano, Pappalardo, G, La Mendola, D, and Isernia, Carla
Subjects: Gene isoform, Circular dichroism, Prions, Pharmaceutical Science, avian prion repeats, NMR, CD, conformational ensemble, polyproline II, Cooperativity, Molecular Dynamics Simulation, Biology, Protein Structure, Secondary, Article, Analytical Chemistry, lcsh:QD241-441, Molecular dynamics, Protein structure, lcsh:Organic chemistry, Drug Discovery, Animals, Amino Acid Sequence, Physical and Theoretical Chemistry, Nuclear Magnetic Resonance, Biomolecular, Protein secondary structure, Peptide sequence, Polyproline helix, Circular Dichroism, Organic Chemistry, Peptide Fragments, Biochemistry, Chemistry (miscellaneous), Biophysics, Molecular Medicine, Avian prion repeat, Chickens
Abstract: Many proteins perform essential biological functions by means of regions that lacking specific organized structure exist as an ensemble of interconverting transient conformers. The characterization of such regions, including the description of their structural propensities, number of conformations and relative populations can provide useful insights. Prion diseases result from the conversion of a normal glycoprotein into a misfolded pathogenic isoform. The structures of mammal and chicken prion proteins show a similar fold with a globular domain and a flexible N-terminal portion that contains different repeated regions: octarepeats (PHGGGWGQ) in mammals and hexarepeats (PHNPGY) in chickens. The higher number of prolines in the hexarepeat region suggests that this region may retain a significant amount of residual secondary structure. Here, we report the CD, NMR and MD characterization of a peptide (2-HexaPY) composed of two hexarepeats. We combine experimental NMR data and MD to investigate at atomic level its ensemble-averaged structural properties, demonstrating how each residue of both repeats has a different quantified PPII propensity that shows a periodicity along the sequence. This feature explains the absence of cooperativity to stabilize a PPII conformation. Nonetheless, such residual structure can play a role in nucleating local structural transitions as well as modulating intra-molecular or inter-molecular interactions © 2013 by the authors.
Published: 2013
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47. Providing QoS strategies and cloud-integration to web servers by means of aspects

Author: Rosario Giunta, Fabrizio Messina, Giuseppe Pappalardo, and Emiliano Tramontana
Subjects: Web server, Computer Networks and Communications, Computer science, business.industry, Distributed computing, Quality of service, Cloud computing, computer.software_genre, Computer Science Applications, Theoretical Computer Science, Scheduling (computing), Computational Theory and Mathematics, Resource management, business, computer, Software
Abstract: The main responsibilities of a web server are to listen from the communication channel and to prepare replies to requests. Additional responsibilities include adapting processing activities, for example, through scheduling or request filtering, so as to satisfy Quality of Service QoS requirements. Typical QoS-related concerns address behavioural constraints e.g. response time bounds, satisfiable by scheduling the most urgent requests first and resource monitoring, for optimal use. Although such concerns are spread across several web server components, they should be handled separately from communication-related ones, for the sake of modularity.
Published: 2013
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48. Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies

Author: Marco Feligioni, Alessandro Sinopoli, Anna Pittaluga, Maria Teresa Ciotti, Corsetti Veronica, Antonella Bobba, Fulvio Florenzano, Antonella Borreca, Danilo Milardi, Gabriele Ciasca, Giuseppe Pappalardo, De Spirito Marco, Gunedalina Olivero, Pietro Calissano, Massimiliano Papi, Giuseppina Amadoro, Anna Atlante, Michele Sciacca, Valentina Latina, and Filomena Iannuzzi
Subjects: 0301 basic medicine, Gerontology, extracellular tau, Brain research, Hippocampal formation, Biology, Settore FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), Synapse, 03 medical and health sciences, 0302 clinical medicine, Research Paper: Gerotarget (Focus on Aging), Alzheimer’s disease, immunotherapy, neurodegeneration, synapse(s), tau cleavage, medicine, Extracellular, tau, Cerebral Spinal Fluid, Gerotarget, Neurodegeneration, Glutamate receptor, Alzheimer's disease, medicine.disease, 3. Good health, Prolonged exposure, 030104 developmental biology, Oncology, Alzheimer, Neuroscience, 030217 neurology & neurosurgery
Abstract: // Fulvio Florenzano 1,* , Corsetti Veronica 2,* , Gabriele Ciasca 3,* , Maria Teresa Ciotti 4 , Anna Pittaluga 5 , Gunedalina Olivero 5 , Marco Feligioni 1,6 , Filomena Iannuzzi 1 , Valentina Latina 2 , Michele Francesco Maria Sciacca 7 , Alessandro Sinopoli 7 , Danilo Milardi 7 , Giuseppe Pappalardo 7 , De Spirito Marco 3 , Massimiliano Papi 3 , Anna Atlante 8,9 , Antonella Bobba 8,9 , Antonella Borreca 4 , Pietro Calissano 1 and Giuseppina Amadoro 1,2 1 European Brain Research Institute, Rome, Italy 2 Institute of Translational Pharmacology, CNR, Rome, Italy 3 Institute of Physics, Catholic University of the Sacred Heart, Largo F Vito 1, Rome, Italy 4 Institute of Cellular Biology and Neuroscience, CNR, IRCSS Santa Lucia Foundation, Rome, Italy 5 Department of Pharmacy, Pharmacology and Toxicology Section, University of Genoa, Genoa, Viale Cembrano, Italy 6 Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Milan, Italy 7 Institute of Biostructures and Bioimaging, CNR, Catania, Italy 8 Institute of Biomembranes and Bioenergetics, CNR, Bari, Italy 9 Center of Excellence for Biomedical Research, University of Genoa, Genoa, Viale Benedetto XV, Italy * These authors have equally contributed to this work Correspondence to: Giuseppina Amadoro, email: // Keywords : extracellular tau, tau cleavage, Alzheimer’s disease, neurodegeneration, synapse(s), Gerotarget Received : March 07, 2017 Accepted : April 11, 2017 Published : April 22, 2017 Abstract The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH 2 -derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies, including Alzheimer’s disease (AD). Here we show that sub-toxic doses of extracellular-applied human NH 2 tau 26-44 (aka NH 2 htau) -which is the minimal active moiety of neurotoxic 20-22kDa peptide accumulating in vivo at AD synapses and secreted into parenchyma- acutely provokes presynaptic deficit in K + -evoked glutamate release on hippocampal synaptosomes along with alteration in local Ca 2+ dynamics. Neuritic dystrophy, microtubules breakdown, deregulation in presynaptic proteins and loss of mitochondria located at nerve endings are detected in hippocampal cultures only after prolonged exposure to NH 2 htau. The specificity of these biological effects is supported by the lack of any significant change, either on neuronal activity or on cellular integrity, shown by administration of its reverse sequence counterpart which behaves as an inactive control, likely due to a poor conformational flexibility which makes it unable to dynamically perturb biomembrane-like environments. Our results demonstrate that one of the AD-relevant, soluble and secreted N-terminally truncated tau forms can early contribute to pathology outside of neurons causing alterations in synaptic activity at presynaptic level, independently of overt neurodegeneration.
Published: 2017
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49. Blockchain Inefficiency in the Bitcoin Peers Network

Author: Tomaso Aste, Giuseppe Pappalardo, Tiziana Di Matteo, and Guido Caldarelli
Subjects: 0301 basic medicine, Transaction inefficiency, FOS: Computer and information sciences, Computer Science - Cryptography and Security, Blockchain, Internet privacy, 02 engineering and technology, Computer security, computer.software_genre, lcsh:Computer applications to medicine. Medical informatics, Computer Science - Computers and Society, 03 medical and health sciences, Proof-of-stake, Computers and Society (cs.CY), 0202 electrical engineering, electronic engineering, information engineering, Economics, business.industry, 020206 networking & telecommunications, Usability, Computer Science Applications, Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, Computational Mathematics, 030104 developmental biology, Incentive, Modeling and Simulation, Bitcoin, lcsh:R858-859.7, Inefficiency, business, computer, Database transaction, Cryptography and Security (cs.CR)
Abstract: We investigate Bitcoin network monitoring the dynamics of blocks and transactions. We unveil that 43\% of the transactions are still not included in the Blockchain after 1h from the first time they were seen in the network and 20\% of the transactions are still not included in the Blockchain after 30 days, revealing therefore great inefficiency in the Bitcoin system. However, we observe that most of these `forgotten' transactions have low values and in terms of transferred value the system is less inefficient with 93\% of the transactions value being included into the Blockchain within 3h. The fact that a sizeable fraction of transactions is not processed timely casts serious doubts on the usability of the Bitcoin Blockchain for reliable time-stamping purposes and calls for a debate about the right systems of incentives which a peer-to-peer unintermediated system should introduce to promote efficient transaction recording., Comment: 15 pages, 8 figures, 3 tables
Published: 2017
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50. New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway

Author: Stefano Salmaso, Nicolò Pettenuzzo, Giuseppe Pappalardo, Marianna Flora Tomasello, Dolores Fregona, Valeria Lanza, Giuseppe Di Natale, Danilo Milardi, Paolo Caliceti, and Chiara Nardon
Subjects: 0301 basic medicine, Drug Screening Assays, HeLa, Mice, 0302 clinical medicine, Drug Discovery, Tumor Cells, Cultured, Tissue Distribution, Solubility, Inbred BALB C, chemistry.chemical_classification, Mice, Inbred BALB C, Cultured, biology, Cyclodextrin, Molecular Structure, Chemistry, General Medicine, Oligosaccharide, Tumor Cells, Biochemistry, 030220 oncology & carcinogenesis, Female, medicine.symptom, Drug, Biodistribution, Proteasome Endopeptidase Complex, Antineoplastic Agents, Proteasome inhibitors, Dose-Response Relationship, 03 medical and health sciences, Structure-Activity Relationship, Thiocarbamates, medicine, Structure–activity relationship, Animals, Humans, Dithiocarbamate, Cell Proliferation, Pharmacology, Cyclodextrins, Dose-Response Relationship, Drug, Ubiquitin, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Water, Antitumor, biology.organism_classification, 030104 developmental biology, Mechanism of action, Anticancer agents, Gold, Drug Screening Assays, Antitumor, Gold complexes
Abstract: The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with our efforts for unravelling its tangled mechanism of action. We used three types of alpha-cyclodextrins (CDs), namely beta-CD, Me-beta-CD and HP-beta-CD to prepare aqueous solutions of AuL12. The ability of these natural oligosaccharide carriers to enhance water solubility of hydrophobic compounds, allowed drug stability of AuL12 to be investigated. Moreover, pharmacokinetic experiments were first carried out for a gold(III) coordination compound, after i.v. injection of the nanoformulation AuL12/HP-beta-CD to female mice. The gold content in the blood samples was detected at scheduled times by AAS (atomic absorption spectrometry) analysis, highlighting a fast biodistribution with a t beta 1/2 of few minutes and a slow escretion (t alpha(1/2) of 14.3 h). The in vitro cytotoxic activity of AuL12 was compared with the AuL12/HP-beta-CD mixture against a panel of three human tumor cell lines (i.e., HeLa, KB and MCF7). Concerning the mechanism of action, we previously reported the proteasome-inhibitory activity of some our gold(III)-based compounds. In this work, we moved from the proteasome target to upstream of the important ubiquitin-proteasome pathway, testing the effects of AuL12 on the polyubiquitination reactions involving the Ub-activating (E1) and -conjugating (E2) enzymes. (C) 2017 Elsevier Masson SAS. All rights reserved.
Published: 2017
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