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11 results on '"Giombolini, C."'

1. Oligoclonal T-lymphocyte expansion in human coronary unstable plaques

Author

DE PALMA, Raffaele, Del Galdo, F, Abbate, G, Ragni, M, Cirillo, P, Giovanni, C, Forte, L, Giuseppe, A, Tritto, I, Giombolini, C, Golino, Paolo, DE PALMA, Raffaele, Del Galdo, F, Abbate, G, Ragni, M, Cirillo, P, Giovanni, C, Forte, L, Giuseppe, A, Tritto, I, Giombolini, C, and Golino, Paolo

Subjects
Plaques, Atherosclerosi, Acute Coronary Syndrome, Atherosclerosis, Acute Coronary Syndromes
Published
2003

10. Platypnea-orthodeoxia induced by fenestrated atrial septal aneurysm

Author

Giombolini, C., Notaristefano, S., Santucci, S., Savino, K., Pasquino, S., Ragni, T., and ambrosio giuseppe

Subjects
Male, Dyspnea, platypnea-orthodeoxia, aneurisma atriale, Posture, Humans, Syndrome, Heart Aneurysm, Middle Aged, Hypoxia, Heart Septal Defects, Atrial, Ultrasonography
Abstract

Platypnea-orthodeoxia is a peculiar syndrome characterized by a right-to-left shunt, which occurs in the upright position. The diagnosis is made by contrast transesophageal echocardiography, paying attention to include contrast visualization in the orthostatic decubitus. The association of this syndrome with a fenestrated atrial septal aneurysm is rare and probably underlies a peculiar and also rare mechanism of shunting in presence of normal pulmonary pressure. We report of a case of a 58-year-old man with a fenestrated atrial septal aneurysm and platypnea-orthodeoxia syndrome treated by surgical closure of the atrial defect.

11. Patients with acute coronary syndrome show oligoclonal T-cell recruitment within unstable plaque: evidence for a local, intracoronary immunologic mechanism

Author

Giovanni Cimmino, Raffaele Calabrò, Salvatore Notaristefano, Paolo Golino, Gianfranco Abbate, Francesco Del Galdo, Raffaele De Palma, Isabella Tritto, Liberato Berrino, Claudio Giombolini, Lavinia Forte, Maria Francesca Papa, Giuseppe Ambrosio, Maria Giovanna Russo, Massimo Chiariello, Francesco Rossi, DE PALMA, R, DEL GALDO, F, Abbate, G, Chiariello, Massimo, Calabro, R, Forte, L, Cimmino, G, Papa, Mf, Russo, Mg, Ambrosio, G, Giombolini, C, Tritto, I, Notaristefano, S, Berrino, L, Rossi, F, Golino, P., DE PALMA, Raffaele, DEL GALDO, F., Abbate, G., Chiariello, M., Calabro', Raffaele, Forte, L., Cimmino, Giovanni, Papa, M., Russo, Maria Giovanna, Ambrosio, G., Giombolini, C., Tritto, I., Notaristefano, S., Berrino, Liberato, Rossi, Francesco, and Golino, Paolo

Subjects
Male, lymphocytes, Acute coronary syndrome, Pathology, medicine.medical_specialty, T cell, T-Lymphocytes, Inflammation, Coronary Disease, T-Cell Antigen Receptor Specificity, lymphocyte, plaque, Immune system, Physiology (medical), medicine, Humans, Aged, Cell Proliferation, Mechanism (biology), business.industry, immune system, inflammation, Middle Aged, medicine.disease, Atherosclerosis, Complementarity Determining Regions, Peripheral blood, Pathophysiology, Clone Cells, Chemotaxis, Leukocyte, Real-time polymerase chain reaction, medicine.anatomical_structure, Acute Disease, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Background— Recent studies indicate that T-cell activation may play an important role in the pathophysiology of acute coronary syndromes (ACS). However, although those studies detected T-cell expansion in peripheral blood cells, demonstration of specific T-cell expansion within the plaque of patients with ACS is lacking. The present study aims to address whether a specific, immune-driven T-lymphocyte recruitment occurs within the unstable plaque of patients with ACS. Methods and Results— We simultaneously examined the T-cell repertoire using CDR3 size analysis both in coronary plaques (obtained by directional atherectomy) and in peripheral blood of patients with either ACS (n=11) or chronic stable angina (n=10). Unstable plaques showed a 10-fold increase in T-cell content by quantitative PCR. Using spectratyping analysis, we found several specific T-cell clonotype expansions only in unstable plaque from each patient with ACS, indicating a specific, antigen-driven recruitment of T cells within unstable lesions. Conclusions— For the first time, T-cell repertoire was investigated directly into coronary plaques; using this approach, we demonstrate that coronary plaque instability in the setting of ACS is associated with immune-driven T-cell recruitment, specifically within the plaque.

Published
2006

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