223 results on '"G. di Pasquale"'
Search Results
2. Clinical Characteristics And Health Care Resources In Patients Treated With Oral Anticoagulants: Evidences From Italian Administrative Databases
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L, Degli Esposti, M, Andretta, G, Di Pasquale, M, Gambera, S, Saragoni, V, Perrone, and S, Buda
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Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Time Factors ,Databases, Factual ,non-vitamin K antagonist oral anticoagulants ,Administration, Oral ,Hemorrhage ,Drug Prescriptions ,Drug Costs ,Medication Adherence ,Risk Factors ,real-world setting ,Atrial Fibrillation ,Humans ,Practice Patterns, Physicians' ,Aged ,Retrospective Studies ,Original Research ,Aged, 80 and over ,Incidence ,Anticoagulants ,vitamin K antagonists ,Treatment Outcome ,Italy ,lcsh:RC666-701 ,Female ,anticoagulation treatment patterns ,Platelet Aggregation Inhibitors ,Non-Valvular Atrial fibrillation - Abstract
L Degli Esposti,1 M Andretta,2 G Di Pasquale,3 M Gambera,4 S Saragoni,1 V Perrone,1 S Buda1 1CliCon S.r.l. Health, Economics & Outcomes Research, Ravenna, Italy; 2Local Pharmaceutical Service, Verona Local Health Authority, Verona, Italy; 3Department of Cardiology, Maggiore Hospital, Bologna, Italy; 4Local Pharmaceutical Service, Bergamo Local Health Authority, Bergamo, ItalyCorrespondence: V PerroneCliCon S.r.l, Health, Economics and Outcomes Research, Via Salara, 36, Ravenna 48100, ItalyTel +39 054438393Fax +39 0544212699Email valentina.perrone@clicon.itObjectives: 1) To evaluate anticoagulation treatment patterns and health care resource use in adult patients with a discharge diagnosis of non-valvular atrial fibrillation (NVAF) in an Italian real-world setting and 2) to describe the characteristics of NVAF patients in relation to treatment.Design: A retrospective cohort study in a “real-world” setting.Setting: Data were analysed by integrating administrative databases that included approximately 2,000,000 individuals assisted by the National Health System from two Italian Local Health Units.Participants: All adult patients with at least one hospital discharge or ≥2 outpatient visits with a diagnosis code for NVAF from 1/01/2011 to 31/12/2015 were included.Main outcome measures: Anticoagulation treatment patterns, health care resource use and major bleeding events that occurred during the follow-up period were evaluated.Results: 32,863 NVAF patients were included, of whom 7,831 had at least one prescription of oral anticoagulants. Among them, 6,876 patients were vitamin K antagonists (VKA) users and 955 were non-vitamin K antagonist oral anticoagulant (NOAC) users at index date (ID). During the follow-up period, the use of antiplatelet drugs was higher among VKA-naïve users than the NOAC-naïve users. Among NOAC users, 76.1% showed an adherence level ≥80% during follow-up. The rate of bleeding events resulted higher for VKA patients compared to NOAC patients. The unadjusted incidence rate was 10.46 per 1000 person-year for VKA patients and 4.55 per 1,000 person-years for NOAC patients. The overall annual cost (in term of drugs, hospitalisations and outpatient specialist services) was € 5,156.13 for VKA and € 4,630.57 for NOAC.Conclusion: This unselected cohort study, on NVAF patients being prescribed oral anticoagulants, highlights that VKA was largely prescribed and the great majority of patients on NOACs were adherent to treatment. Most of the OAC patients still received antiplatelet agents in combination, and in NOAC patients, we registered a lower number of bleeding events compared with VKA.Keywords: non-valvular atrial fibrillation, vitamin K antagonists, non-vitamin K antagonist oral anticoagulants, anticoagulation treatment patterns, real-world setting
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- 2019
3. Clinical Characteristics And Health Care Resources In Patients Treated With Oral Anticoagulants: Evidences From Italian Administrative Databases
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Valentina Perrone, Margherita Andretta, Stefania Saragoni, Marco Gambera, G Di Pasquale, Stefano Buda, and L. Degli Esposti
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Database ,business.industry ,Endocrinology, Diabetes and Metabolism ,Public Health, Environmental and Occupational Health ,Atrial fibrillation ,Retrospective cohort study ,Hematology ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,computer.software_genre ,03 medical and health sciences ,0302 clinical medicine ,Health care ,medicine ,Resource use ,Pharmacology (medical) ,In patient ,030212 general & internal medicine ,Diagnosis code ,Medical prescription ,Cardiology and Cardiovascular Medicine ,business ,computer ,Cohort study - Abstract
Objectives 1) To evaluate anticoagulation treatment patterns and health care resource use in adult patients with a discharge diagnosis of non-valvular atrial fibrillation (NVAF) in an Italian real-world setting and 2) to describe the characteristics of NVAF patients in relation to treatment. Design A retrospective cohort study in a "real-world" setting. Setting Data were analysed by integrating administrative databases that included approximately 2,000,000 individuals assisted by the National Health System from two Italian Local Health Units. Participants All adult patients with at least one hospital discharge or ≥2 outpatient visits with a diagnosis code for NVAF from 1/01/2011 to 31/12/2015 were included. Main outcome measures Anticoagulation treatment patterns, health care resource use and major bleeding events that occurred during the follow-up period were evaluated. Results 32,863 NVAF patients were included, of whom 7,831 had at least one prescription of oral anticoagulants. Among them, 6,876 patients were vitamin K antagonists (VKA) users and 955 were non-vitamin K antagonist oral anticoagulant (NOAC) users at index date (ID). During the follow-up period, the use of antiplatelet drugs was higher among VKA-naive users than the NOAC-naive users. Among NOAC users, 76.1% showed an adherence level ≥80% during follow-up. The rate of bleeding events resulted higher for VKA patients compared to NOAC patients. The unadjusted incidence rate was 10.46 per 1000 person-year for VKA patients and 4.55 per 1,000 person-years for NOAC patients. The overall annual cost (in term of drugs, hospitalisations and outpatient specialist services) was € 5,156.13 for VKA and € 4,630.57 for NOAC. Conclusion This unselected cohort study, on NVAF patients being prescribed oral anticoagulants, highlights that VKA was largely prescribed and the great majority of patients on NOACs were adherent to treatment. Most of the OAC patients still received antiplatelet agents in combination, and in NOAC patients, we registered a lower number of bleeding events compared with VKA.
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- 2019
4. Authorship: From Credit to Accountability
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Ignacio Ferreira-González, G. Di Pasquale, M. del Pilar Aguilar Passano, Faouzi Addad, François Mach, Eckart Fleck, Jan J. Piek, Ginghina C, Jean-Jacques Monsuez, Chu-Pak Lau, М. Aschermann, Yangsoo Jang, Kjell Nikus, Mario Ivanuša, A. Dibra, Carlos Eduardo Rochitte, Mamanti Rogava, Livio Dei Cas, Ulrike Fortmüller, Fernando Alfonso, Robert Hatala, Ariel Cohen, Alexander Mrochek, Lino Gonçalves, Echeverri D, Parounak Zelveian, Claes Held, Dilek Ural, Anetta Undas, Plamen Gatzov, Tzung-Dau Wang, Mahmoud Hassanein, Zlatko Fras, Nuray Enç, Laila Haddour, Sebija Izetbegovic, Germanas Marinskis, Slobodan Obradović, Olaf Rødevand, Evgeny Shlyakhto, Luc Pierard, Andreas J. Flammer, Dimitris Tousoulis, Mikael Sander, Çetin Erol, Valentyn Shumakov, Anton Doubell, Albert Varga, Kurt Huber, Kanat Kabdrakhmanov, Alfonso Buendia Hernandez, Michael Boehm, Faiq Guliyev, Gerd Heusch, and Ismael Guzman Melgar
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media_common.quotation_subject ,scientific journals ,journals ,scientific process ,0603 philosophy, ethics and religion ,03 medical and health sciences ,0302 clinical medicine ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,Quality (business) ,030212 general & internal medicine ,Medical journal ,authorship ,media_common ,business.industry ,06 humanities and the arts ,editorial ethics ,accountability ,Work (electrical) ,RC666-701 ,Paradigm shift ,Accountability ,Engineering ethics ,060301 applied ethics ,Cardiology and Cardiovascular Medicine ,business - Abstract
The Editors' Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.
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- 2019
5. Realization and characterization of carbon black based fractional order element
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G. Di Pasquale, Riccardo Caponetto, Antonino Pollicino, Emanuele Murgano, Salvatore Graziani, and Karabi Biswas
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0209 industrial biotechnology ,Materials science ,Fractional order element ,Frequency analysis ,Model identification ,Structured material ,Electronic, Optical and Magnetic Materials ,Atomic and Molecular Physics, and Optics ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electrical and Electronic Engineering ,Hardware_PERFORMANCEANDRELIABILITY ,02 engineering and technology ,Dielectric ,Topology ,01 natural sciences ,law.invention ,Coatings and Films ,020901 industrial engineering & automation ,Hardware_GENERAL ,law ,Atomic and Molecular Physics ,0103 physical sciences ,Electronic ,Hardware_INTEGRATEDCIRCUITS ,Optical and Magnetic Materials ,010302 applied physics ,General Engineering ,Carbon black ,Surfaces ,Capacitor ,and Optics - Abstract
In this papers the possibility of realizing fractional capacitors by using carbon black nanostructured dielectrics is investigated. Capacitors have been realized by varying the percentage of distributed carbon black. The frequency analysis of the capacitors has been, therefore, performed. The Bode diagrams outline that this class of devices shows a non integer order behavior. Moreover, a dependance between the curing temperature and the fractional order has been shown.
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- 2018
6. Modeling of a Fractional Order Element Based on Bacterial Cellulose and Ionic Liquids
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Emanuele Murgano, G. Di Pasquale, Riccardo Caponetto, A. Pollicino, Salvatore Graziani, and Carlo Trigona
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Materials science ,02 engineering and technology ,Fractional order ,01 natural sciences ,Bacterial cellulose ,chemistry.chemical_compound ,Biopolymers ,0103 physical sciences ,Frequency domain analysis ,Cellulose ,Instrumentation ,010302 applied physics ,Mechanical Engineering ,021001 nanoscience & nanotechnology ,Computer Science Applications ,Ionic liquids ,Order (biology) ,chemistry ,Chemical engineering ,Control and Systems Engineering ,Frequency domain ,Ionic liquid ,0210 nano-technology ,Information Systems - Abstract
In this paper, a novel fractional-order element (FOE) is modeled in a wide frequency range. The FOE is based on a green biopolymer, i.e., bacterial cellulose (BC), infused with ionic liquids (ILs). The modeling is performed in the frequency domain and a lumped-circuit model is proposed. The model is an evolution with respect to a simpler one already introduced by the authors, for a narrower frequency range. Results show that ILs generate a quite complex frequency domain behavior, which can be described in the framework of FOEs. Furthermore, results on the time stability of the device under investigation are given.
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- 2021
7. Use and reuse of amphorae. Wine residues in Dressel 2–4 amphorae from Oplontis Villa B (Torre Annunziata, Italy)
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M. Thomas, Jennifer L. Muslin, Mauro Paolo Buonincontri, Alessandra Pecci, L. Toniolo, I. van der Graaff, John R. Clarke, G. Di Pasquale, G. M. Crisci, Domenico Miriello, Pecci, A., Clarke, J., Thomas, M., Muslin, J., van der Graaff, I., Toniolo, L., Miriello, D., Crisci, G. M., Buonincontri, M. P., and Di Pasquale, G.
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Wine ,History ,010506 paleontology ,Archeology ,Dressel 2â 4 amphorae ,Archeology (arts and humanities) ,060102 archaeology ,06 humanities and the arts ,Gas chromatographyâ mass spectrometry ,01 natural sciences ,Archaeology ,Organic residue analysi ,Amphorae content ,Campanian wine ,Geography ,Oplontis Villa B ,0601 history and archaeology ,0105 earth and related environmental sciences - Abstract
Under the aegis of the ongoing international Oplontis Project we carried out organic residue analyses on thirteen samples from eleven Dressel 2–4 amphorae recovered at Villa B at Oplontis (Torre Annunziata, Southern Italy) in order to identify their content and to characterize their visible lining. Although the content of Dressel 2–4 amphorae is usually thought to be wine, no residue analyses have been carried out until now to verify it. Analyses were carried out with Gas chromatography coupled to mass spectrometry. The results of the analyses indicate that all the amphorae were coated with Pinaceae products which had undergone different stages of preparation. Moreover, they confirm that Dressel 2–4 contained wine, or its derivatives, as wine markers were identified in all the samples. The data we obtained demonstrated that the amphorae analyzed were not new vessels, expressly made to trade the wine produced in the surrounding area, but were ready to be reused.
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- 2017
8. Commentary: What is the relationship between Covid-19 and cardiovascular disease?
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G. Di Pasquale, Claudio Rapezzi, and Roberto Ferrari
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,biology ,business.industry ,Disease ,Cardiovascular disease ,Infections ,medicine.disease_cause ,biology.organism_classification ,medicine.disease ,Virology ,NO ,Pneumonia ,Pandemic ,medicine ,Covid-19 ,Cardiology and Cardiovascular Medicine ,business ,Coronavirus Infections ,Betacoronavirus ,Coronavirus - Published
- 2020
9. 2387Recurrent cardiovascular events and mortality in relation to antiplatelet therapy in patients with myocardial infarction without obstructive coronary artery disease (MINOCA)
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William E. Boden, David P. Faxon, Christopher B. Granger, Valentin, Campbell D. Joyner, Shamir R. Mehta, Current Oasis trial investigators, Jean-François Tanguay, Rafael Diaz, Matthias Bossard, A Budaj, Peggy Gao, Adnan Kastrati, Salim Yusuf, Phillippe Gabriel Steg, and G. Di Pasquale
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Cardiovascular event ,medicine.medical_specialty ,business.industry ,Coronary arteriosclerosis ,medicine.disease ,Clopidogrel ,Coronary artery disease ,Internal medicine ,medicine ,Cardiology ,In patient ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background Approximately 10% of patients presenting with myocardial infarction (MI) do not have obstructive coronary artery disease (MINOCA). The role of antiplatelet therapy and outcomes in this group remain unclear. We assessed prognosis and the effect of an intensified clopidogrel regimen in MINOCA patients. Methods We analyzed data from the CURRENT-OASIS 7 trial, which randomized 25,086 patients with acute coronary syndromes (ACS) referred for early intervention to receive either double-dose (600mg day 1; 150mg days 2–7; then 75mg daily) or standard-dose (300mg day 1; then 75mg daily) clopidogrel. We evaluated clinical outcomes at 30-days in patients with versus without obstructive CAD and in relation to standard versus double-dose clopidogrel. Results Overall, 23,783 MI patients were included, of which 1,599 (6.7%) had MINOCA. MINOCA patients were younger, more frequently presented with non-ST-segment elevation MI and had fewer comorbidities. Rates of all-cause mortality (0.7% versus 2.4%, p=0.0046), cardiovascular mortality (0.6 versus 2.2%, p=0.0056), repeat MI (0.5% versus 2.3%, p=0.0009) and major bleedings (0.7% versus 2.5%, p=0.0001) were significantly lower among patients with MINOCA versus those with obstructive CAD. Compared with the standard-dose clopidogrel regimen, the double-dose regimen appeared to increase the risk of cardiovascular death, MI or stroke in MINOCA patients (0.8% versus 2.1%, hazard ratio (HR) 2.74, P=0.033). There was no difference in those with obstructive CAD (4.7% versus 4.4%, HR 0.93, P=0.226; P-for-interaction=0.023) (see Figure 1A). Major bleeding did not occur more frequently in MINOCA patients with double- versus standard-dose clopidogrel regimen (0.7% versus 0.6%, (HR 1.16 (95% CI 0.35–3.80), p=0.805), but their rate was higher In MI patients with obstructive CAD (2.7% versus 2.2% (HR 1.26 (95% CI 1.06–1.49), p=0.008) (Figure 1B). Figure 1A & B Conclusions Compared to MI patients with obstructive CAD, patients presenting with MINOCA represent a distinct cohort, which is generally younger, has a higher NSTEMI prevalence and fewer comorbidities. Their risk for adverse events, especially repeat MI, stroke, death, and bleeding, is low ( Acknowledgement/Funding The CURRENT-OASIS 7 trial was sponsored by Sanofi-Aventis and Bristol-Myers Squibb.
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- 2019
10. The performance of the damage survey and safety evaluation form in Marche Region
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A. Martinelli, G. Cifani, G. Di Pasquale, C. Spuri, L. Corazza, Andrea Cherubini, and G. Orsini
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- 2018
11. Assessment of the economic loss from the GNDT-DPC-SSN safety evaluation forms
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G. Di Pasquale, C. Serra, and G. Orsini
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- 2018
12. Realization of green fractional order devices by using bacterial cellulose
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Salvatore Graziani, G. Di Pasquale, Riccardo Caponetto, Emanuele Murgano, and Antonino Pollicino
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Carbon composite ,chemistry.chemical_classification ,Materials science ,020206 networking & telecommunications ,Fractional order ,02 engineering and technology ,Polymer ,Experimental evidence ,Bacterial cellulose ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Order (biology) ,Electronic device ,chemistry ,Chemical engineering ,Energy production ,0202 electrical engineering, electronic engineering, information engineering ,Derived cellulose ,Carbon composites ,Electrical and Electronic Engineering ,Cellulose ,Realization (systems) ,030217 neurology & neurosurgery - Abstract
In this paper, we propose and demonstrate the possibility of using Bacterial Cellulose (BC), a bio-derived polymer, for the realization of fractional order electronic devices. BC, unlike plant-derived cellulose, is produced by some genera of bacteria, if a suitable culture is maintained. Compared to plant-derived cellulose, BC can be obtained with a green and low-energy production process, which does not produce pollutants nor carbon composites. BC is used as the bulk in a capacitor-like structure. The device impedance has been investigated and experimental evidence of its fractional nature is given. A model is proposed and a possible explanation of the involved phenomena is provided.
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- 2019
13. Carbon Black based capacitive Fractional Order Element towards a new electronic device
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Luigi Fortuna, Salvatore Graziani, Riccardo Caponetto, Antonino Pollicino, G. Di Pasquale, and Arturo Buscarino
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Fabrication ,Materials science ,Capacitive sensing ,Low-pass filter ,Fractional order element ,Model identification ,Nano structured dielectrics ,Non integer order filters ,Electrical and Electronic Engineering ,02 engineering and technology ,Dielectric ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Nano ,0202 electrical engineering, electronic engineering, information engineering ,RC circuit ,Frequency analysis ,business.industry ,020208 electrical & electronic engineering ,Carbon black ,Optoelectronics ,business ,030217 neurology & neurosurgery - Abstract
In this paper, Fractional Order Elements (FOEs), fabricated by using a carbon black nano structured dielectrics, are presented. FOEs have been realized by varying different fabrication parameters such as the percentage of carbon black, the curing temperature, and the solvent type. Results on the experimental frequency characterization of one FOE device are given. The FOE has been, then, used for demonstrating the possibility of realizing a fractional order RC filter. The frequency analysis of the RC filter shows the coherence of the fractional order between the FOE and corresponding RC circuit.
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- 2018
14. An Inkjet Printed CO2 Gas Sensor
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Salvatore Baglio, G. Di Pasquale, C. Gugliuzzo, Antonino Pollicino, Cristian O. Lombardo, Bruno Ando, S. D’Agata, and G. Re
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nkjet printing ,Gas sensor, PEDOT/PSS ,Graphene ,Interdigited electrodes ,PET ,Materials science ,Fabrication ,Nanotechnology ,General Medicine ,Substrate (printing) ,law.invention ,Carbon dioxide sensor ,Responsivity ,Inkjet printing ,PEDOT:PSS ,law ,Electrode ,PEDOT/PSS ,Gas sensor ,Electrical conductor ,Engineering(all) - Abstract
In this paper a low cost CO2 sensor realized on a plastic substrate is presented. The sensor is realized by the deposition of a double layer of PEDOT/PSS (CLEVIOS™ PHCV4, by H.C. Starck) and Graphene on InterDigiTed electrodes printed onto a PET (PolyEthylene Terephthalate) substrate. The InterDigiTed electrodes have been realized by inkjet printing a conductive pattern of a silver nano-particle solution (Metalon® JS-B15P by Novacentrix), through a commercial EPSON® inkjet printer. The sensing principle of the sensor exploits the change in electrical conductivity of graphene due to gas molecules adsorbtion. A device responsivity, at 30 °C, of 45 μOhm/ppm and a sensitivity of 100 ppm have been obtained respectively. Compared to solutions proposed in the literature, the inkjet printed device here presented has advantages related to its low cost, flexibility and low demanding fabrication. The device flexibility is crucial for application requiring the device shaping to irregular surfaces, such as dresses or food packaging.
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- 2015
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15. Constructive features and seismic vulnerability of historic centres through the rapid assessment of historic building stocks. The experience of Ferrara, Italy
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DOLCE, MAURO, E. Speranza, G. Di Pasquale, R. Dalla Negra, M. Zuppiroli, F. Bocchi, L. Toniolo, M. Boriani, G. Guidi, Dolce, Mauro, E., Speranza, G., Di Pasquale, R., Dalla Negra, M., Zuppiroli, and F., Bocchi
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Civil defense ,business.industry ,Vulnerability ,Socio-culturale ,Usability ,Seismic damage ,Civil engineering ,Constructive ,Masonry building ,Seismic vulnerability ,Rapid assessment ,Geography ,Work (electrical) ,Building stock ,Joint (building) ,Vulnerability class ,Architecture ,business ,Masonry Building, Building Stock, Seismic Vulnerability, Seismic Damage, Vulnerability Class ,Environmental planning - Abstract
During the earthquake emergency which involved Emilia Romagna Region (Italy) since 20th of May 2012, the Italian Civil Protection Department (DPC) undertook, with prevention purposes, an extensive survey on the ordinary buildings of the historic centre of the town of Ferrara, around 30 km far from the epicentral area. The activity, carried out in close cooperation with local authorities, was aimed at enhancing the seismic emergency response of the town in case of a possible further seismic event, as well as collecting technical information on the structural characteristics of the buildings, to be elaborated and hence used for further prevention purposes. Innovative element of the project was the use of two joint survey operative tools, consisting of the AeDES form used by DPC for post-earthquake usability assessments (2007) and AS form (specific for historical building blocks) which have been experimentally combined in this occasion. Activities were coordinated by DPC and carried out in collaboration with the Architecture Department of the University of Ferrara, which provided an operative and scientific support in the whole development of the work.
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- 2015
16. L'evoluzione delle procedure per la ricostruzione dell'edilizia privata nel post-sisma dal 1980 al 2009
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DOLCE, MAURO, DI LUDOVICO, MARCO, PROTA, ANDREA, C. Moroni, F. Papa, G. Di Pasquale, M. Severino, M. Dolce, G. Manfredi, Dolce, Mauro, C., Moroni, F., Papa, G., Di Pasquale, DI LUDOVICO, Marco, Prota, Andrea, and M., Severino
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- 2015
17. Alcune considerazioni sui contributi rilasciati dallo Stato per la ricostruzione privata nel post-sisma
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M. Severino, G. Di Pasquale, DI LUDOVICO, MARCO, DOLCE, MAURO, MANFREDI, GAETANO, PROTA, ANDREA, F. Poletti, M., Severino, DI LUDOVICO, Marco, G., Di Pasquale, Dolce, Mauro, Manfredi, Gaetano, and Prota, Andrea
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- 2014
18. A new class of ionic electroactive polymers based on green synthesis
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Alvo Aabloo, Salvatore Graziani, Urmas Johanson, G. Di Pasquale, V. De Luca, R Puglisi, C. Gugliuzzo, Antonino Pollicino, and C. Marino
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Ionic eletroactive polymers, Nanocomposites, Green chemistry, Ionic polymer metal composites, Characterization, Electromechanical transduction ,Materials science ,Characterization ,Ionic bonding ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,engineering.material ,010402 general chemistry ,Platinum nanoparticles ,01 natural sciences ,Nanocomposites ,Electromechanical transduction ,Ionic polymer–metal composites ,chemistry.chemical_compound ,Polymer chemistry ,Electroactive polymers ,Electrical and Electronic Engineering ,Instrumentation ,Nanocomposite ,Metals and Alloys ,Ionic polymer metal composites ,Ionic eletroactive polymers ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Green chemistry ,engineering ,Noble metal ,Artificial muscle ,0210 nano-technology - Abstract
In this paper, a novel class of ionic electroactive nanocomposites, named Ionic Polymer-Polymer Metal Composites (IP 2 MCs) is introduced. IP 2 MCs are capable of electromechanical transduction and, therefore, they are suitable to be used as nanocomposite artificial muscles. They represent an evolution of a class of totally polymeric ionic electroactive polymers, named Ionic Polymer Composites (IP 2 Cs), previously proposed by some of the Authors. Compared to the parent technology, IP 2 MCs exploit both the beneficial effects of electrodes based on polymeric conductors and the use of noble metal (Pt) nanoparticles. The deposition of platinum nanoparticles is obtained through a green chemical reduction process. The fabrication process, and the influence of the novel nanocomposite electrode on the thermal, mechanical, and electromechanical behavior of green IP 2 MCs are described together with a comparison with the properties of Ionic Polymer Metal Composites (IPMCs) and IP 2 Cs. Reported results allow concluding that electroactive devices, with performances comparable with those of IPMC actuators, can be obtained. Eventually, the production procedure is more environmental friendly, cheaper and faster than the corresponding technique used for IPMC fabrication.
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- 2016
19. Viral Gene Transfer to Developing Mouse Salivary Glands
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Kenneth M. Yamada, Jeff Chi-feng Hsu, G. Di Pasquale, John A. Chiorini, Tomohiro Onodera, Matthew P. Hoffman, and Jill S. Harunaga
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Fibroblast Growth Factor 7 ,Genes, Viral ,viruses ,Genetic Vectors ,Green Fluorescent Proteins ,Cell Culture Techniques ,Biology ,Transfection ,Salivary Glands ,Adenoviridae ,Cell Line ,Mesoderm ,Mice ,Transduction (genetics) ,Organ Culture Techniques ,Genes, Reporter ,Transduction, Genetic ,Gene expression ,Morphogenesis ,Animals ,Humans ,General Dentistry ,Tissue Survival ,Regulation of gene expression ,Luminescent Agents ,Lentivirus ,HEK 293 cells ,Gene Transfer Techniques ,Gene Expression Regulation, Developmental ,Gene targeting ,Research Reports ,Epithelial Cells ,Dependovirus ,Embryonic stem cell ,Molecular biology ,HEK293 Cells ,Cell culture ,Feasibility Studies ,Cattle ,Plasmids - Abstract
Branching morphogenesis is essential for the formation of salivary glands, kidneys, lungs, and many other organs during development, but the mechanisms underlying this process are not adequately understood. Microarray and other gene expression methods have been powerful approaches for identifying candidate genes that potentially regulate branching morphogenesis. However, functional validation of the proposed roles for these genes has been severely hampered by the absence of efficient techniques to genetically manipulate cells within embryonic organs. Using ex vivo cultured embryonic mouse submandibular glands (SMGs) as models to study branching morphogenesis, we have identified new vectors for viral gene transfer with high efficiency and cell-type specificity to developing SMGs. We screened adenovirus, lentivirus, and 11 types of adeno-associated viruses (AAV) for their ability to transduce embryonic day 12 or 13 SMGs. We identified two AAV types, AAV2 and bovine AAV (BAAV), that are selective in targeting expression differentially to SMG epithelial and mesenchymal cell populations, respectively. Transduction of SMG epithelia with self-complementary (sc) AAV2 expressing fibroblast growth factor 7 (Fgf7) supported gland survival and enhanced SMG branching morphogenesis. Our findings represent, to our knowledge, the first successful selective gene targeting to epithelial vs. mesenchymal cells in an organ undergoing branching morphogenesis.
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- 2011
20. Bovine AAV transcytosis inhibition by tannic acid results in functional expression of CFTR in vitro and altered biodistribution in vivo
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Lynda S. Ostedgaard, William D. Swaim, D Vermeer, G. Di Pasquale, Philip H. Karp, and John A. Chiorini
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Genetic enhancement ,Genetic Vectors ,Cell ,Cystic Fibrosis Transmembrane Conductance Regulator ,Respiratory Mucosa ,Biology ,Article ,Exocytosis ,Mice ,Transduction (genetics) ,In vivo ,Genetics ,medicine ,Animals ,Tissue Distribution ,Molecular Biology ,Gene Transfer Techniques ,respiratory system ,Dependovirus ,Molecular biology ,In vitro ,Cystic fibrosis transmembrane conductance regulator ,medicine.anatomical_structure ,Transcytosis ,biology.protein ,Molecular Medicine ,Tannins - Abstract
Bovine adeno-associated virus (BAAV) can enter a cell either through a transcytosis or transduction pathway. We previously demonstrated that particles entering via the transcytosis pathway can be redirected to transduce the cell by blocking particle exocytosis with tannic acid (TA). To investigate whether this approach is useful in lung gene therapy applications, we tested the effect of TA on BAAV transduction in cystic fibrosis airway epithelia in vitro, and in mouse lung in vivo. Our findings suggest that BAAV transcytosis can occur in vivo and that treatment with TA reduces transcytosis and increases lung transduction. TA treatment did not impair the sorting and the activity of the BAAV expressed cystic fibrosis transmembrane regulator membrane protein.
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- 2011
21. Convenient and reproducible in vivo gene transfer to mouse parotid glands
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T. Shinomiya, G. Di Pasquale, Cm M. Goldsmith, Changyu Zheng, and B J Baum
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Saliva ,Pathology ,medicine.medical_specialty ,Transgene ,Biology ,medicine.disease_cause ,Molecular biology ,Parotid gland ,Viral vector ,law.invention ,Adenoviridae ,medicine.anatomical_structure ,stomatognathic system ,Otorhinolaryngology ,In vivo ,law ,medicine ,Recombinant DNA ,Luciferase ,General Dentistry - Abstract
Oral Diseases (2010) 17, 77–82 Objectives: Published studies of gene transfer to mouse salivary glands have not employed the parotid glands. Parotid glands are the likely target tissue for most clinical applications of salivary gene transfer. The purpose of the present study was to develop a convenient and reproducible method of retroductal gene transfer to mouse parotid glands. Methods: The volume for vector delivery was assessed by infusion of Toluidine Blue into Stensen’s ducts of Balb/c mice after direct intraoral cannulation. Recombinant, serotype 5 adenoviral vectors, encoding either firefly luciferase or human erythropoietin (hEpo), were constructed and then administered to parotid glands (107 vector particles/gland). Transgene expression in vivo was measured by enzyme activity (luciferase) or an enzyme-linked immunosorbent assay (hEpo). Vector biodistribution was measured by real-time quantitative (Q) PCR. Results: The chosen volume for mouse parotid vector delivery was 20 μL. Little vector was detected outside of the targeted glands, with both QPCR and luciferase assays. Transgene expression was readily detected in glands (luciferase, hEpo), and serum and saliva (hEpo). Most secreted hEpo was detected in saliva. Conclusion: These studies show that mouse parotid glands can be conveniently and reproducibly targeted for gene transfer, and should be useful for pre-clinical studies with many murine disease models.
- Published
- 2010
22. 298 Testosterone and Cardiovascular Risk: Meta-Analysis of Observational and Interventional Studies
- Author
-
Edoardo Mannucci, G. Di Pasquale, Giulia Rastrelli, Martina Maggi, Giovanni Corona, and Alessandra Sforza
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Urology ,Endocrinology, Diabetes and Metabolism ,Testosterone (patch) ,Psychiatry and Mental health ,Endocrinology ,Reproductive Medicine ,Internal medicine ,Meta-analysis ,medicine ,Observational study ,business - Published
- 2018
23. All-Organic Motion Sensors: Electromechanical Modeling
- Author
-
Luigi Fortuna, E. Umana, Donata Nicolosi, M. La Rosa, Giovanni Sicurella, G. Di Pasquale, and Salvatore Graziani
- Subjects
chemistry.chemical_classification ,Conductive polymer ,Materials science ,business.industry ,ionic polymer–polymer composites ,Ionic bonding ,Transduction (psychology) ,Polymer ,Conductivity ,organic conductors ,All-organic sensors and actuators ,Membrane ,chemistry ,Electrode ,Optoelectronics ,Electrical and Electronic Engineering ,Actuator ,business ,Instrumentation - Abstract
A new class of materials called ionic polymer-polymer composites has been investigated to demonstrate the sensing and acting capabilities of these all-organic structures. Samples have been realized by covering Nafion membranes, with Orgacon 3040 conducting polymer as electrode material. Membranes whose electrodes were manufactured using the drop-casting technique exhibited the best electromechanical performances. Sensors have been tested in a dedicated experimental setup to model their electromechanical transduction behavior. Thus, the obtained model has been validated.
- Published
- 2009
24. The Essentials of Essential Fatty Acids
- Author
-
Mauro G. Di Pasquale
- Subjects
education.field_of_study ,Nutrition and Dietetics ,Fatty Acids, Essential ,Linolenic acid ,Linoleic acid ,Efa deficiency ,Population ,Nutritional Requirements ,Biology ,Dietary Fats ,Diet ,chemistry.chemical_compound ,chemistry ,Biochemistry ,Physical performance ,Fatty Acids, Omega-6 ,Fatty Acids, Omega-3 ,Exercise performance ,Humans ,Pharmacology (medical) ,Food science ,education ,Food Science - Abstract
All fats, including saturated fatty acids, have important roles in the body. However, the most important fats are those that the body cannot make and thus must come from the food we eat. These essential fatty acids (EFAs) are based on linoleic acid (omega-6 group) and alpha-linolenic acid (omega-3 group). We need both groups of essential fatty acids to survive. For various reasons EFA deficiency is common in the general population, as is a disproportionate intake of omega-6 fatty acids over omega-3 fatty acids. As such, it is important to eat the right foods to make sure that you're taking in enough and the right kinds of the essential fatty acids. However, there is much more to the story. Studies have shown that increasing the intake of certain essential fatty acids, either alone or in combination with other fats and compounds, can increase health, help in treating certain diseases, and even improve body composition, mental and physical performance.
- Published
- 2009
25. Kinetic study of the thermal degradation of PS/MMT nanocomposites preparedwith imidazolium surfactants
- Author
-
Ignazio Blanco, Elena Fabbri, Lorenzo Abate, Francesco A. Bottino, Antonino Pollicino, Alice Orestano, and G. Di Pasquale
- Subjects
chemistry.chemical_classification ,Materials science ,polystyrene ,Condensed Matter Physics ,thermal stability ,Styrene ,Thermogravimetry ,chemistry.chemical_compound ,Montmorillonite ,Chemical engineering ,chemistry ,nanocomposites ,Polymer chemistry ,activation energy of degradation ,Thermal stability ,Physical and Theoretical Chemistry ,In situ polymerization ,Thermal analysis ,Glass transition ,Alkyl - Abstract
Styrene and montmorillonite organically modified with imidazolium surfactants (MMT) at various alkyl chain lengths (C12, C16 and C18) were used to prepare the corresponding PS/MMT/C12, PS/MMT/C16 and PS/MMT/C18 nanocomposites by in situ polymerization. XRD and TEM analyses evidenced the formation of both intercalated and exfoliated structures. The glass transition temperatures (Tg) of nanocomposites, as well as that of neat PS, were obtained by DSC measurements. The thermal degradations were carried out in the scanning mode, in both inert and oxidative environments, and the initial temperatures of decomposition (Ti) and the apparent activation energies of degradation (Ea) were determined. Due to an oxidative degradation mechanism, the Ti and Ea values in air atmosphere were lower than those under nitrogen.
- Published
- 2008
26. Introduzione
- Author
-
BERETTA, MARCO, G. di Pasquale, M. BERETTA G. DI PASQUALE, M. Beretta, and G. di Pasquale
- Published
- 2004
27. Seismic vulnerability of historic centres through the building blocks. The experience of Ferrara, Italy
- Author
-
DOLCE, MAURO, E. Speranza, G. Di Pasquale, R. Dalla Negra, M. Zuppiroli, F. Bocchi, Dolce, Mauro, E., Speranza, G., Di Pasquale, R., Dalla Negra, M., Zuppiroli, and F., Bocchi
- Published
- 2013
28. Holocene palaeofires in Neotropics high mountains: The contribution of soil charcoal analysis
- Author
-
Fabio Marzaioli, Emilia Allevato, G. Di Pasquale, Filippo Terrasi, S. Impagliazzo, Isabella Passariello, Allevato, Emilia, Impagliazzo, S., Passariello, I., Marzaioli, F., Terrasi, F., DI PASQUALE, Gaetano, E., Allevato, S., Impagliazzo, I., Passariello, Marzaioli, Fabio, Terrasi, Filippo, and G., Di Pasquale
- Subjects
visual_art ,visual_art.visual_art_medium ,Holocene climatic optimum ,Physical geography ,Stratification (vegetation) ,Environmental history ,Charcoal ,Arid ,Fire history ,Archaeology ,Geology ,Holocene ,Earth-Surface Processes - Abstract
The Holocene palaeofires in Southern America has been generally attributed to climate until the middle Holocene and to human activities for later periods. Soil charcoal analysis and extensive AMS dating were carried out on six soil profiles, between 3400 and 3900 m a.s.l. in the Guandera Biological Reserve (Western Cordillera Real, North Ecuador). AMS results showed an ordered stratification of charcoals allowing a fire history reconstruction over the last 11,700 cal BP. The reported fire occurrences fit well with Holocene global scale arid periods. The association between fires and climate signals suggested a marginal role of humans in the environmental history of the studied area. Here, the human inference started at ca 2500 cal BP, but became considerable only in the last millennium.
- Published
- 2013
29. Indici di operatività per la valutazione della condizione limite di emergenza (CLE)
- Author
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DOLCE, MAURO, E. Speranza, G. Di Pasquale, F. Giordano, F. Bocchi, Dolce, Mauro, E., Speranza, G., Di Pasquale, F., Giordano, and F., Bocchi
- Published
- 2013
30. A Multipurpose Method for Seismic Vulnerability Assesment of Urban Areas
- Author
-
DOLCE, MAURO, G. Di Pasquale, E. Speranza, Dolce, Mauro, G., Di Pasquale, and E., Speranza
- Abstract
The present work outlines a methodological framework for “ordering” through progressive levels of analyses different evaluation models concerning the seismic vulnerability at urban scale, with respect to the possibl e final objectives: seismic scenarios, emergency or urban planning , as far as seismic mitigation or economical estimates. The research work has been developed within the URBISIT Project, funded by Italian Civil Department (DPC). The paper illustrates t he general framework governing each assessment level and the mutual relation between each of them. Following, e ach level of analyses is systematically described also through some recent applications , carried out o n some representative Italian urban centres . In the end, a correlation among different assessment levels is carried out in order to better fo cus the usability of each model as well as its reliability with respect to the possible objectives . Finally some conclusions are drawn and possible developmen t of the research outlined.
- Published
- 2012
31. Le Linee Guida della Protezione Civile per la riduzione della vulnerabilità sismica degli elementi non strutturali
- Author
-
DOLCE, MAURO, A. De Sortis, G. Di Pasquale, S. Gregolo, S. Papa, G. F. Rettore, Dolce, Mauro, A., De Sorti, G., Di Pasquale, S., Gregolo, S., Papa, and G. F., Rettore
- Published
- 2012
32. Linee Guida per le modalità di indagine sulle strutture e sui terreni per i progetti di riparazione, miglioramento e ricostruzione di edifici inagibili
- Author
-
S. Aversa, F. da Porto, G. Di Pasquale, S. Foti, L. Griffini, G. Lanzo, C. Modena, P. Monaco, G. Montella, C. Moroni, G. Naso, D. Pingitore, D. Ricci, SILVESTRI, FRANCESCO, A. L. Simonelli, G. Totani, V. Venturi, DOLCE, MAURO, MANFREDI, GAETANO, PROTA, ANDREA, S., Aversa, F., da Porto, G., Di Pasquale, Dolce, Mauro, S., Foti, L., Griffini, G., Lanzo, Manfredi, Gaetano, C., Modena, P., Monaco, G., Montella, C., Moroni, G., Naso, D., Pingitore, Prota, Andrea, D., Ricci, Silvestri, Francesco, A. L., Simonelli, G., Totani, and V., Venturi
- Abstract
Le presenti linee guida sono state redatte con lo scopo di fornire un supporto ai tecnici impegnati nella redazione di progetti di intervento per strutture classificate con esito E a seguito del sisma del 6 aprile 2009; in particolare, si pone l???attenzione sui criteri da utilizzare per la progettazione del piano di prove sui materiali e sui terreni nel rispetto delle prescrizioni di legge vigenti.
- Published
- 2012
33. Interventi strutturali (di riparazione o intervento locale)
- Author
-
BALSAMO, ALBERTO, DOLCE, MAURO, MANFREDI, GAETANO, PROTA, ANDREA, G. Di Pasquale, C. Moroni, M. Dolce, G. Manfredi, Balsamo, Alberto, G., Di Pasquale, Dolce, Mauro, Manfredi, Gaetano, C., Moroni, and Prota, Andrea
- Published
- 2011
34. Interventi non strutturali
- Author
-
BALSAMO, ALBERTO, DOLCE, MAURO, MANFREDI, GAETANO, PROTA, ANDREA, G. Di Pasquale, C. Moroni, M. Dolce, G. Manfredi, Balsamo, Alberto, G., Di Pasquale, Dolce, Mauro, Manfredi, Gaetano, C., Moroni, and Prota, Andrea
- Published
- 2011
35. Soil charcoal analysis as a climato-stratigraphical tool: the key case of Cordillera Real,northern Andes
- Author
-
Isabella Passariello, E. Russo Ermolli, M. Marziano, Carmine Lubritto, S. Impagliazzo, G. Di Pasquale, DI PASQUALE, Gaetano, Impagliazzo, S., Lubritto, C., Marziano, M., Passariello, I., RUSSO ERMOLLI, Elda, G., DI PASQUALE, S., Impagliazzo, Lubritto, Carmine, M., Marziano, I., Passariello, and E., RUSSO ERMOLLI
- Subjects
Nuclear and High Energy Physics ,Pedoanthracology ,Geographic area ,Younger Drya ,El Abra ,law.invention ,Palaeofire ,14C ,law ,visual_art ,paleoclimate ,visual_art.visual_art_medium ,Key (lock) ,paleofires ,Physical geography ,Younger Dryas ,Stadial ,Radiocarbon dating ,Charcoal ,AMS dating ,Instrumentation ,Fire history ,Geology - Abstract
The present study represents the first attempt of reconstructing fire history through soil charcoal dating. The investigated area is located in the Guandera Biological Reserve (western Cordillera Real, northern Ecuador). Six AMS radiocarbon dating, performed at the base of five soil profiles allowed a fire phase to be identified during the Pleistocene-Holocene transition. A strong correspondence was highlighted between the age of the Guandera fires and the El Abra stadial, which is considered the Younger Dryas equivalent in South America. This local evidence of fires contributes to define the geographic area in which the El Abra stadial was recorded and suggests a wider use of the soil charcoal analysis. © 2009 Elsevier B.V.
- Published
- 2010
36. Contents Vol. 92, 2002
- Author
-
Sun Woo Lim, Choung Soo Kim, Bertalan Fodor, Yukihiko Kawasaki, Hirofumi Matuoka, Tadao Oohara, Shozo Hosokawa, Y. Asano, Su-Kil Park, Izzet Yavuz, Yasuhide Nakashima, K. Tamba, E. Kusano, Jung Ho Cha, A. Concheiro Guisan, Seval Izdes, Giuseppe Rizzuto, Kaori Kanegae, Yasuo Imanishi, Sumiko Homma, Chul Woo Yang, Sadayoshi Ito, A. Sturiale, Müjdat Yenicesu, Toshiaki Makino, Cheri V. Barrett, Toshihiko Miwa, Yasuro Kumeda, Chin-Huang Chen, Nora Klenk, Chun-Cheng Hou, Hitoshi Suzuki, J. Charles Jennette, Cüneyt Ensari, Shoji Nogae, Won Seok Yang, Ju Young Jung, Ken Farrington, Massimino Senatore, Hitoshi Goto, Tülin Gümüş, Mükerrem Safali, Yi-Hong Chou, Yoshiyuki Tomiyoshi, Ottó Árkossy, Ronald J. Falk, Jorge Isaac, Gilbert Deray, Ruriko Nozawa, Gloria A. Preston, N. Frisina, Abdülgaffar Vural, Junzo Suzuki, Shigeru Nakai, Masaaki Inaba, Toshikatsu Shimizu, J.A. Camacho Diaz, Magdolna Aleksza, Wei-Ming Hsu, Akihiko Osajima, Magali Ciroldi, Petra Marchand, Erzsébet Ladányi, Hirofumi Anai, Sacit Turanli, Hyung Wook Kim, T. Rengarajan, Patrizia Colombo, M. Suzuki, Y. Watanabe, Wu-Chang Yang, Yasuhiro Akai, Masahito Tamura, F. Corica, Eri Muso, Koichiro Homma, L. Garcia Garcia, Jürgen Floege, Xixin Wu, Motoaki Miyazono, A. Gimenez Llort, Laurence Fardet, Motoshi Hattori, F. Floccari, Aquiles Jara, Yoshihiko Saito, Eveline Sowa, Zeki Odabaşi, Yoko Fujino, Song Lin, Vincent Launay-Vacher, Júlia Széll, Lee-Moi Thien, Silvia Pierangeli, Koji Harada, Jaime Pereira, Akane Kurisu, Nai-Phon Wang, Tomoko Nakamura, R. Ravichandran, Susumu Makino, Mária Takács, Marcela Vasquez, Masahiro Okazaki, Yuri Ozawa, Yong Soo Kim, G. Di Pasquale, Chiew H. Kong, A. Ruello, Hassane Izzedine, Takeshi Suda, Luigia Costantini, Itsuro Kazama, Tsen-Tsai Chen, A. Favaloro, A. Romeo, M. Sommer, Ryuichiro Konda, Hiroshi Shiraga, Hideo Nakai, Soon Bae Kim, J. Gerth, Michele Buemi, G. Anastasi, Oliviero Filiberti, Sándor Sipka, Tatsuya Nakatani, Takahiko Nagahama, Keiji Fujiwara, Kyoko Kitauchi, Masayuki Iwano, Narutoshi Kabashima, Satoru Kawaguchi, Takanobu Sakemi, Yasushi Asano, Carla Peona, Akira Owada, Satish M. Rao, Sigeyuki Takeda, Naoko Matsumoto, Jung Sik Park, Tsung-Hsiu Wang, Michiko Suzuki, Hidehiro Kakizaki, Masao Kanauchi, Aranka Koós, Iván Palomo, Yasuhiro Komatsu, Mari Michimata, Pasqualina Cecere, Kayser Caglar, Y. Oyama, Sang Koo Lee, Giovanna Piccini, Lin Shan, Deniz Ayli, O. Iimura, M. Buemi, Mitsunobu Matsubara, Takao Saruta, J. Vila Cots, Yee-Yung Ng, Katsuya Nonomura, Toru Shinzato, Eiji Kusano, Masako Iwamoto, G. Stein, Shigehisa Aoki, Masuhisa Nakamura, Takeshi Kanda, G. Cutroneo, U. Eismann, Qiu Mingcai, Toshio Hashimoto, Ulf Janssen, Masamiki Miwa, Susan L. Hogan, Takayuki Ota, Kosei Segawa, A. Vila Santandreu, Mayumi Nagata, Yutaka Imai, Omac Tufekcioglu, Yoshiyuki Matsuo, Heinfried H. Radeke, David A. Alcorta, An S. De Vriese, Takahiko Ono, Paik-Seong Lim, Gisho Honda, Arnold J. Felsenfeld, Katsumi Ito, Chang-Linct Yang, M. Imai, Yutaro Hayashi, Koichi Hayashi, Bum Soon Choi, C. Aloisi, Enikő Sárváry, Cecilia Chacón, Wan Young Kim, Marcelo Alarcón, Tsutomu Araki, Byung Kee Bang, Jin Kim, Huaji Chen, Shigeo Suzuki, Gabriella Lakos, Attila Nagy, Yoshiki Nishizawa, C. Ito, Can Li, Fuad S. Shihab, Yuujiro Watanabe, A O Phillips, Toshihiko Hata, Kenji Maeda, Lesley C Dinwiddie, Eiji Ishimura, Shin Suda, Antonio Nicoletti, Chui-Mei Tiu, Norio Kurumatani, Seung Hun Lee, and Ning Liu
- Subjects
Traditional medicine ,business.industry ,Medicine ,business - Published
- 2002
37. Subject Index Vol. 92, 2002
- Author
-
Satoru Kawaguchi, Takanobu Sakemi, Ken Farrington, Itsuro Kazama, Yukihiko Kawasaki, Hidehiro Kakizaki, Masao Kanauchi, Toshihiko Hata, Y. Oyama, Sang Koo Lee, Mitsunobu Matsubara, Hiroshi Shiraga, T. Rengarajan, Patrizia Colombo, Kenji Maeda, Takao Saruta, Masaaki Inaba, Eiji Kusano, Oliviero Filiberti, Erzsébet Ladányi, Shigehisa Aoki, Sumiko Homma, Sadayoshi Ito, Abdülgaffar Vural, Hitoshi Suzuki, Hyung Wook Kim, Yasuhiro Akai, F. Corica, Takahiko Ono, Koji Harada, Giovanna Piccini, Yoshiyuki Tomiyoshi, Gilbert Deray, Sun Woo Lim, Sándor Sipka, Sigeyuki Takeda, Masayuki Iwano, Takeshi Kanda, Aquiles Jara, Júlia Széll, Arnold J. Felsenfeld, Cecilia Chacón, Zeki Odabaşi, Yoko Fujino, Yasuro Kumeda, Nora Klenk, Chin-Huang Chen, Lesley C Dinwiddie, Qiu Mingcai, Satish M. Rao, Iván Palomo, Hitoshi Goto, Choung Soo Kim, Akane Kurisu, Pasqualina Cecere, Eiji Ishimura, Hirofumi Anai, Bertalan Fodor, Jorge Isaac, Yong Soo Kim, Paik-Seong Lim, Gisho Honda, Tatsuya Nakatani, Toru Shinzato, Antonio Nicoletti, M. Imai, Masuhisa Nakamura, Mükerrem Safali, Byung Kee Bang, Fuad S. Shihab, U. Eismann, Michiko Suzuki, Yuujiro Watanabe, Toshikatsu Shimizu, Luigia Costantini, Lin Shan, Deniz Ayli, M. Buemi, Shigeo Suzuki, J. Vila Cots, Gabriella Lakos, Vincent Launay-Vacher, Carla Peona, Akira Owada, Aranka Koós, Yoshihiko Saito, Yasuhide Nakashima, Jin Kim, Huaji Chen, Akihiko Osajima, Petra Marchand, Mari Michimata, Masako Iwamoto, Yee-Yung Ng, Toshio Hashimoto, J. Gerth, G. Anastasi, Chui-Mei Tiu, R. Ravichandran, G. Cutroneo, J.A. Camacho Diaz, Magdolna Aleksza, Song Lin, Susan L. Hogan, A O Phillips, Kayser Caglar, Eri Muso, Shin Suda, Koichiro Homma, Y. Watanabe, Wu-Chang Yang, Katsuya Nonomura, Attila Nagy, Cheri V. Barrett, Sacit Turanli, Susumu Makino, Norio Kurumatani, Yoshiki Nishizawa, Yutaka Imai, Seung Hun Lee, Ning Liu, Takahiko Nagahama, Ulf Janssen, F. Floccari, Lee-Moi Thien, Nai-Phon Wang, Jürgen Floege, Chiew H. Kong, G. Stein, A. Romeo, Xixin Wu, Ryuichiro Konda, Izzet Yavuz, Soon Bae Kim, Müjdat Yenicesu, Masahiro Okazaki, Y. Asano, Su-Kil Park, C. Aloisi, Takayuki Ota, Mayumi Nagata, Giuseppe Rizzuto, Wan Young Kim, Masamiki Miwa, Yuri Ozawa, Mária Takács, Chang-Linct Yang, A. Ruello, Kaori Kanegae, Yasuo Imanishi, Marcela Vasquez, Kyoko Kitauchi, A. Sturiale, Motoaki Miyazono, Toshiaki Makino, Gloria A. Preston, David A. Alcorta, Yasushi Asano, Hideo Nakai, Kosei Segawa, Yutaro Hayashi, A. Vila Santandreu, A. Gimenez Llort, Laurence Fardet, G. Di Pasquale, Yoshiyuki Matsuo, Takeshi Suda, Naoko Matsumoto, Masahito Tamura, Jung Sik Park, K. Tamba, Koichi Hayashi, E. Kusano, Omac Tufekcioglu, Chun-Cheng Hou, Toshihiko Miwa, J. Charles Jennette, Cüneyt Ensari, Yasuhiro Komatsu, Shoji Nogae, Won Seok Yang, Ju Young Jung, A. Favaloro, Jung Ho Cha, Enikő Sárváry, Ottó Árkossy, Ronald J. Falk, C. Ito, Junzo Suzuki, Marcelo Alarcón, Can Li, O. Iimura, Motoshi Hattori, Keiji Fujiwara, Chul Woo Yang, Silvia Pierangeli, Jaime Pereira, Tsutomu Araki, Shigeru Nakai, L. Garcia Garcia, Heinfried H. Radeke, An S. De Vriese, M. Sommer, Michele Buemi, Katsumi Ito, Massimino Senatore, Narutoshi Kabashima, Bum Soon Choi, Tülin Gümüş, Yi-Hong Chou, Ruriko Nozawa, N. Frisina, Wei-Ming Hsu, Magali Ciroldi, Hirofumi Matuoka, Tadao Oohara, Shozo Hosokawa, A. Concheiro Guisan, Seval Izdes, M. Suzuki, Eveline Sowa, Hassane Izzedine, Tsen-Tsai Chen, Tomoko Nakamura, and Tsung-Hsiu Wang
- Subjects
Index (economics) ,business.industry ,Statistics ,Medicine ,Subject (documents) ,business - Published
- 2002
38. Rilievi speditivi: sopralluoghi per l’agibilità sismica
- Author
-
DOLCE, MAURO, MANFREDI, GAETANO, DI LUDOVICO, MARCO, PROTA, ANDREA, VERDERAME, GERARDO MARIO, G. Di Pasquale, V. Albanese, D. Benetti, F. Bramerini, S. Coppari, A. Corina, G. De Rosa, A. De Sortis, P. Emili, R. Ferlito, L. Filippi, F. Giordano, A. Goretti, T. Lo Presti, A. Lucantoni, M. Mercuri, C. Moroni, N. Orlandi, G. Paoli, F. Papa, A. Pizza, F. Procida, M. Rinaldelli, S. Sergio, M. Severino, E. Speranza, A. Veschi, E. Zambonelli, G. Palermo, L. Corazza, G. Cifani, A. Mannella, A. Martinelli, Dolce, Mauro, G., Di Pasquale, V., Albanese, D., Benetti, F., Bramerini, S., Coppari, A., Corina, G., De Rosa, A., De Sorti, P., Emili, R., Ferlito, L., Filippi, F., Giordano, A., Goretti, T., Lo Presti, A., Lucantoni, M., Mercuri, C., Moroni, N., Orlandi, G., Paoli, F., Papa, A., Pizza, F., Procida, M., Rinaldelli, S., Sergio, M., Severino, E., Speranza, A., Veschi, E., Zambonelli, Manfredi, Gaetano, DI LUDOVICO, Marco, G., Palermo, Prota, Andrea, Verderame, GERARDO MARIO, L., Corazza, G., Cifani, A., Mannella, and A., Martinelli
- Published
- 2009
39. From IPMC transducers to all-organic transducers
- Author
-
G. Di Pasquale, E. Umana, and Salvatore Graziani
- Subjects
Electroactive polymers ,motion transducers ,characterization ,Transducer ,Materials science ,Ionic bonding ,Nanotechnology ,Characterization (materials science) - Abstract
This paper presents a summary about the research activity performed on characterizations and modeling of new polymeric transducers. More specifically, Ionic Polymer–Metal Composites (IPMCs) have been widely explored and a new class of totally organic transducers: Ionic Polymer-Polymer Composites (IP2Cs) have been introduced. The manufacturing technique, the electromechanical characterization and modeling of these polymeric transducers are described.
- Published
- 2014
40. An investigation of the structure–property relationships in ionic polymer polymer composites (IP2Cs) manufactured by polymerization in situ of PEDOT/PSS on Nafion ® 117
- Author
-
F G Messina, Salvatore Graziani, E. Umana, Antonino Pollicino, G. Di Pasquale, and R Puglisi
- Subjects
Materials science ,Ionic bonding ,thermal and mechanical analyses ,chemistry.chemical_compound ,PEDOT:PSS ,structure-property relationships ,Nafion ,Electroactive polymers ,General Materials Science ,Electrical and Electronic Engineering ,Composite material ,Civil and Structural Engineering ,Conductive polymer ,chemistry.chemical_classification ,Electroactive Polymers (EAPs) ,Ionic Polymer Polymer Composites (IP2Cs) ,electromechanical characterization ,Polymer ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,chemistry ,Polymerization ,Mechanics of Materials ,Signal Processing ,Electrode - Abstract
Ionic polymer polymer composites (IP2Cs) are all-organic electroactive polymers (EAPs) that show sensing and actuation capabilities when a deformation or a voltage is applied, respectively. They are fabricated starting from an ionic polymer coated on both sides with a conducting polymer as electrode element. In this work, poly(3,4-ethylendioxytiophene)–poly-(styrenesulfonate) (PEDOT/PSS) has been polymerized directly on Nafion®117 membrane and devices have been manufactured varying the polymerization time. Water and ethylene glycol (EG) have been used as solvents. The obtained IP2Cs have been characterized using thermal and mechanical analyses and electromechanically tested. The results have shown that in IP2Cs manufactured by polymerization in situ the PEDOT/PSS layer adheres very strongly on the Nafion®117 film, improving the possibility of rehydrating the devices after use. Moreover, taking into account that the different polymerization times influence the uniformity of the surface of the organic electrode and, consequently, both device stiffness and electrode conductivity, the structure–property relationships of the obtained devices have been investigated. The influence of the different solvents inside the devices has also been studied when IP2Cs have been used as actuators or sensors. Reported results show that it is possible to modulate the performances of IP2Cs by varying some manufacture parameters and the solvent.
- Published
- 2014
41. IPMC frequency dependent multiphysics model considering electrodes high surface and fractional effects
- Author
-
V. De Luca, G. Di Pasquale, Salvatore Graziani, F. Sapuppo, and Riccardo Caponetto
- Subjects
High surface ,frequency-domain analysis ,electroactive polymer actuators ,optimisation ,business.industry ,Multiphysics ,Electrode ,Electrical engineering ,Medicine ,Mechanical engineering ,business - Published
- 2014
42. ANMCO/SICI-GISE paper on antiplatelet therapy in acute coronary syndrome
- Author
-
A. Fiscella, Stefano Savonitto, Marco Marini, Rosanna Abbate, Federico Piscione, Massimiliano Conte, Ferdinando Varbella, Roberto Ceravolo, G. Gonzi, L La Vecchia, E. Di Lorenzo, N. B. Grieco, Filippo Ottani, Paolo Sbarzaglia, G. De Luca, Francesco Prati, Alessandro Lupi, Capranzano P, F. M. Bovenz, Alberto Cremonesi, G. B. Danzi, S. Cordone, A. Navazio, Serena Rakar, Francesco Bovenzi, L. Bolognese, Stefano Galli, Francesco Saia, A. Cremonesi, Giuseppe Biondi-Zoccai, L. Oltrona Visconti, Andrea Perkan, M. Del Pinto, Giampaolo Scorcu, Emanuela Piccaluga, Nazario Carrabba, E. Piccaluga, Claudio Cavallini, N. Signore, S. Rakar, G. P. Perna, Giampaolo Pasquetto, R. Ravasio, Felicita Andreotti, R. Farina, Gianni Casella, Antonio Montinaro, Giuseppe Patti, Pietro Giudice, Roberto Caporale, M. Marzilli, Serafina Valente, Corrado Lettieri, M. Vatrano, Leonardo De Luca, G. Satullo, M. Valgimigli, Maddalena Lettino, Guido Parodi, Roberta Rossini, A. Macchi, Pierfranco Terrosu, Rubboli A, Giovanni Esposito, Gian Battista Danzi, Ugo Limbruno, Giuseppe Tarantini, L. De Luca, S. De Servi, Marco Valgimigli, Zoran Olivari, Giuseppe Musumeci, Cesare Greco, D. Formigli, M. Lazzari, G. Di Pasquale, Jacopo Oreglia, Federico Ronco, Paola Colombo, Davide Capodanno, Leonardo Bolognese, Marco Tubaro, Gennaro Sardella, Luca Testa, De Luca, L., Bolognese, L., Valgimigli, M., Ceravolo, R., Danzi, G. B., Piccaluga, E., Rakar, S., Cremonesi, A., Bovenzi, F. M., Abbate, R., Andreotti, F., Biondi-Zoccai, G., Capodanno, D., Caporale, R., Capranzano, P., Carrabba, N., Casella, G., Cavallini, C., Colombo, P., Conte, M. R., Cordone, S., Del Pinto, M., De Servi, S., Di Lorenzo, E., Di Pasquale, G., Esposito, G., Farina, R., Fiscella, A., Formigli, D., Galli, S., Giudice, P., Gonzi, G., Greco, C., Grieco, N. B., La Vecchia, L., Lazzari, M., Lettieri, C., Lettino, M., Limbruno, U., Lupi, A., Macchi, A., Marini, M., Marzilli, M., Montinaro, A., Musumeci, G., Navazio, A., Olivari, Z., Oltrona Visconti, L., Oreglia, J. A., Ottani, F., Parodi, G., Pasquetto, G., Patti, G., Perkan, A., Perna, G. P., Piscione, F., Prati, F., Ravasio, R., Ronco, F., Rossini, R., Rubboli, A., Saia, F., Sardella, G., Satullo, G., Savonitto, S., Sbarzaglia, P., Scorcu, G., Signore, N., Tarantini, G., Terrosu, P., Testa, L., Tubaro, M., Valente, S., Varbella, F., and Vatrano, M.
- Subjects
Drug ,Acute coronary syndrome ,medicine.medical_specialty ,Ticagrelor ,Prasugrel ,media_common.quotation_subject ,Antiplatelet agent ,law.invention ,chemistry.chemical_compound ,Cangrelor ,Randomized controlled trial ,law ,Internal medicine ,medicine ,media_common ,Aspirin ,business.industry ,Antiplatelet agents ,Acute coronary syndrome, Antiplatelet agents, Aspirin ,Cangrelor, Clopidogrel, Prasugrel, Ticagrelor, Cardiology and Cardiovascular Medicine ,medicine.disease ,Clopidogrel ,chemistry ,Cardiology ,business ,Cardiology and Cardiovascular Medicine ,medicine.drug - Abstract
Antiplatelet therapy is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS). Over the last years, several studies have evaluated old and new oral or intravenous antiplatelet agents in ACS patients. In particular, research was focused on assessing superiority of two novel platelet adenosine diphosphate (ADP) P2Y12 receptor antagonists (i.e. prasugrel and ticagrelor) over clopidogrel. Several large randomized controlled trials have been undertaken in this setting and a wide variety of pre-specified and post hoc analyses are available that evaluated the potential benefits of novel antiplatelet therapies in different subsets of patients with ACS. The aim of this document is to review recent data on the use of current antiplatelet agents for in-hospital treatment of ACS patients. For each drug or class of drugs, strong evidence and/or areas of uncertainty that warrant further research are highlighted by examining 10 subgroups of patients with ACS.
- Published
- 2014
43. The Italian Contribution to the USGS PAGER Project
- Author
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A. Goretti, F. Bramerini, G. Di Pasquale, DOLCE, MAURO, S. Lagomarsino, S. Parodi, IERVOLINO, IUNIO, VERDERAME, GERARDO MARIO, A. Bernardini, A. Penna, M. Rota, A. Masi, M. Vona, A., Goretti, F., Bramerini, G., Di Pasquale, Dolce, Mauro, S., Lagomarsino, S., Parodi, Iervolino, Iunio, Verderame, GERARDO MARIO, A., Bernardini, A., Penna, M., Rota, A., Masi, and M., Vona
- Subjects
Seismic vulnerability, RC, masonry, PAGER - Abstract
The USGS-PAGER Project is devoted to rapidly assess the consequences of severe earthquakes in the world. To improve the inventory and the vulnerability estimate, USGS made recourse to the EERI World Housing Encyclopedia (WHE) project, a web-based network of experts from around the world. A small group of experts, established by EERI, drafted a simple form to collect information at national level. For each country it was required to select the most significant construction types and to provide both the value of the collapse probability conditional upon seismic intensity and the fraction of population that lives and works in these construction types. Italy participated to the project and the Italian form was filled by the Seismic Risk Office-DPC. Several other research units accepted to participate to the project: RU-Genoa, RU-Naples, RU-Padua, RU-Pavia/Eucentre, RU-Potenza. The paper presents the contribution of the Italian Research Units to the PAGER project, providing an insight into the used methodologies and a comparison of the results.
- Published
- 2008
44. Kinetic study of the thermal degradation of some poly(arylenether)s containing naphthalene units
- Author
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G. Di Pasquale, S. Calanna, Lorenzo Abate, and Antonino Pollicino
- Subjects
chemistry.chemical_classification ,Polymers and Plastics ,Organic Chemistry ,Ether ,Polymer ,Branching (polymer chemistry) ,chemistry.chemical_compound ,chemistry ,Phenylene ,Polymer chemistry ,Materials Chemistry ,Moiety ,Thermal stability ,Thermal analysis ,Naphthalene - Abstract
The degradations of five aromatic thermoplastics, containing carbonyl, ether and sulfone linkages and in whose repeating units the –ArCONaphCOAr– moiety (where Ar=1,4 substituted phenylene; Naph=2,6 substituted naphthalene) was present, were performed under N 2 flow in dynamic heating conditions. The obtained results suggested that degradations occurred through random chain scission followed by branching and crosslinking, which partially superimposed with the initial process. The Kissinger method was used to determine the apparent activation energy ( E a ) associated with the first degradation stage, and double linear relationships, attributable to slow diffusion of degradation products in the melt, were found in some cases. A thermal stability classification among the studied polymers was made on the basis of the obtained E a values. This classification was compared with those previously obtained for two analogous groups of thermoplastics and some correlations between thermal stability and polymer chain structure were drawn.
- Published
- 2000
45. Evaluation of trial-based eligibility for device therapy in the real world: extent of the overlap between trial generated profiles and associated patients outcomes at 1 year
- Author
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BORIANI, GIUSEPPE, DIEMBERGER, IGOR, RAPEZZI, CLAUDIO, G. Gorini, L. Gonzini, D. Lucci, G. F. Sinagra, G. Di Pasquale, L. Tavazzi, A. P. Maggioni, G. Boriani, I. Diemberger, C. Rapezzi, G. Gorini, L. Gonzini, D. Lucci, G.F. Sinagra, G. Di Pasquale, L. Tavazzi, and A.P. Maggioni
- Published
- 2007
46. Heart failure and trial generated patients' profile for implant with electrical devices: real-world prevalence, outcomes and public health implications
- Author
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BORIANI, GIUSEPPE, RAPEZZI, CLAUDIO, DIEMBERGER, IGOR, A. P. Maggioni, M. Gorini, G. F. Sinagra, G. Di Pasquale, L. Tavazzi, G. Boriani, C. Rapezzi, A.P. Maggioni, I. Diemberger, M. Gorini, G.F. Sinagra, G. Di Pasquale, and L. Tavazzi
- Published
- 2006
47. Synthesis and characterization of new poly(arylene ether)s based on dihydroxynaphthalene isomers
- Author
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Francesco A. Bottino, G. Di Pasquale, Nicoletta Leonardi, and Antonino Pollicino
- Subjects
chemistry.chemical_classification ,Materials science ,Ketone ,Condensation polymer ,Polymers and Plastics ,Organic Chemistry ,Arylene ,Ether ,Polymer ,Sulfone ,chemistry.chemical_compound ,chemistry ,Polymer chemistry ,Materials Chemistry ,Thermal stability ,Glass transition - Abstract
A series of new poly(arylene ether ketone)s and poly(arylene ether sulfone)s, obtained starting from dihydroxynaphthalene isomers, have been prepared by solution condensation polymerization. The polymers, having inherent viscosities from 0.20 to 0.77 dl g −1 , have been obtained in quantitative yields, had excellent thermal stability as shown by 10% weight loss temperatures in nitrogen and air (above 460 and 430°C, respectively) and high glass transition temperatures (in the range 151–278°C). X-ray diffraction patterns confirmed the semicrystalline character of some polymers. The location of the naphthalene-ether bond appears to affect the polymer properties.
- Published
- 1998
48. Vol. 16, 1998
- Author
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Jeroen P. Kooman, Carlo Massimetti, Michele Buemi, Zhong Yan Guan, Vjeka Raos, Sandro Feriozzi, Peter R. Mertens, G. Di Pasquale, Alessandro Allegra, N. Busch, Daniele Pontillo, Enzo Ancarani, Brian J.G. Pereira, A. J. Luik, M. Ruello, Nikica Thaller, Nicola Frisina, Francesco Corica, Tatjana Jeren, M.S. Giaccobe, Bertrand L. Jaber, Heinz-Günter Sieberth, Adolfo Romeo, Andrew J. King, Thomas Schönfelder, Vaidyanathapuram S. Balakrishnan, Mary C. Perianayagam, Aldo Capezzuto, Bernhard Heintz, Stefano Costantini, Stefan Handt, Horst Kierdorf, Yun Cai Yang, Branka Jeren-Strujić, K.M.L. Leunissen, Yong Ming Yang, Zoran Živković, Carmela Aloisi, Hanns-Ulrich Marschall, and Miguel Cendoroglo
- Subjects
Engineering ,Nephrology ,business.industry ,Hematology ,General Medicine ,business - Published
- 1998
49. [Untitled]
- Author
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S. Di Carlo, M. R. Bassani, G. Di Pasquale, A.D. La Rosa, S. Facchetti, and A. Recca
- Subjects
chemistry.chemical_classification ,Materials science ,Mechanical Engineering ,Glass fiber ,Thermal decomposition ,Polymer ,Cyclopentanone ,Thermogravimetry ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Mechanics of Materials ,Yield (chemistry) ,Polyamide ,General Materials Science ,Composite material ,Pyrolysis - Abstract
Thermogravimetry and on-line flash pyrolysis–gas chromatography–mass spectrometry were used for studying thermal decomposition processes in filled polyamides deriving from used cars. The thermal decomposition of each polymer begins at about 350 °C and proceeds with a weight loss of 100% for the non-glass fibres, under nitrogen atmosphere. The analysis of the pyrolyzate compounds shows that from polyamide 66, the most abundant product volatile at degradation temperatures is cyclopentanone, while from polyamide 6 there is a considerable yield of e-caprolactam.
- Published
- 1997
50. A Disposable Ammonia Sensor by Low-Cost Ink-Jet Printing Technology
- Author
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Bruno Ando, Cristian O. Lombardo, G. Di Pasquale, Vincenzo Marletta, and Salvatore Baglio
- Subjects
Ammonia ,chemistry.chemical_compound ,Materials science ,chemistry ,business.industry ,Optoelectronics ,business ,Volume concentration - Abstract
In this paper a gas sensor for low concentration of ammonia detection realized by a low-cost printed technology is presented. The proposed sensor behaves in an integral mode up to 100 ppm of ammonia, and it is particularly suitable for applications where fast response, low cost, and the availability of disposable devices are mandatory.
- Published
- 2013
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