1. Lymph node metastasis in T1 colorectal cancer: Risk factors and prediction model
- Author
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Fujino, Shiki, Miyoshi, Norikatsu, Kitakaze, Masatoshi, Yasui, Masayoshi, Ohue, Masayuki, Osawa, Hideki, Ide, Yoshihito, Sueda, Toshinori, Tei, Mitsuyoshi, Takeda, Takashi, Danno, Katsuki, Suzuki, Yozo, Noura, Shingo, Ohshima, Kenji, Morii, Eiichi, Takahashi, Hidekazu, Uemura, Mamoru, Yamamoto, Hirofumi, Murata, Kohei, Doki, Yuichiro, and Eguchi, Hidetoshi
- Subjects
Articles - Abstract
Endoscopic resection is typically performed for early T1 stage colorectal cancer (T1 CRC). Additional surgery is subsequently recommended based on pathological findings; however, the current criteria may result in overtreatment. The present study aimed to re-examine the reported risk factors for lymph node (LN) metastasis in T1 CRC and develop a prediction model using a large multi-institutional dataset. In this retrospective study, the medical records of 1,185 patients with T1 CRC who underwent surgery between January 2008 and December 2020 were investigated. Slides pathologically re-assessable for additional risk factors were re-examined. A total of 251 patients with inadequate data were excluded, and 934 patients were randomly assigned at a ratio of 3:1 to the training and validation datasets. In the univariate analysis, left-sided CRC (P=0.003), deep submucosal invasion depth (P=0.005), poor histological grade (P=0.020), lymphatic invasion (P
- Published
- 2023