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Physical activity could be considered one of the factors that affect the immune system status and function. To find the relation between exercise and cytokines, we examined the possible effects of an 8-week endurance training program on the serum levels of cytokines, including tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in sedentary men. A total of 30 healthy young male volunteers were randomly divided into an endurance training group and a control group. The training group followed a specific exercise protocol (running on a treadmill for 15~30 min at 50~70% maximal heart rate) for 8 weeks and the control group did not participate in any exercise program. Venous blood samples were collected from both the groups 24 h before and 24 h and 48 h after the exercise. Repeated ANOVA was used for statistical purposes. The serum levels of TNF-α and IFN-γ were determined by ELISA. Significant (p0.05) decreases were observed in the serum levels of IFN-γ and TNF-α, respectively, after the 8-week endurance training program. Our findings indicated that an 8-week endurance exercise may affect the serum levels of some inflammatory cytokines, suggesting the beneficial role of this training protocol in elderly population and people with certain conditions (inflammation of the vertebrae or other inflammatory diseases).

Objectives: In this study for surveying the relation between exercise and immune cell, we examine the effect of Effect of 8 weeks endurance training on immune system cell changes with recovery period. Study design: Experimental study Methods: participant of this research including health and yang males that were randomized divided into two groups :( ETG) endurance training groups with 15 men; and (CG) 13 men in to control group. Different factor of anthropometric characteristics (i.e. age, weight & height) and also white blood cell (i.e. lymphocyte, neutrophils, monocytes) were experimented. In this study, subjects, runs on a treadmill for 15-30 min at 50 % - 70% maximal Heart rate for 8 weeks, with Venous blood sample was taken at pre, post and at 24- hours and 48-hours after exercise. For data analyze, we used of one -way using repeated-measurements ANOVA, in SPSS12. And also Significance was evaluated as P < 0.05.In addition, all values are expressed as mean ± standard deviation. Results: we found that lymphocyte level increased after 4th week and 48h-recovery, but decreased after 8th week (Mid-exercise), and 24h- recovery in exercise group. Also levels of Neutrophils and Monocytes decreased after after 4th week (Mid-exercise), post- exercise (8th week), 24h- recovery and 48h-recoveries in exercise group. Conclusion: These data demonstrate that a period endurance exercise leads to Levels changes of leukocytes after exercise and recovery period, but these changes not significant.