1. Na + , K + -ATPase, a new class of plasma membrane receptors
- Author
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Aperia, Anita Chatarina, Akkuratov, Evgeny E., Fontana, Jacopo Maria, and Brismar, Hjalmar
- Subjects
respiratory system - Abstract
The Na+-K+-ATPase (NKA) differs from most other ion transporters, not only in its capacity to maintain a steep electrochemical gradient across the plasma membrane, but also as a receptor for a family of cardiotonic steroids, to which ouabain belongs. Studies from many groups, performed during the last 15 years, have demonstrated that ouabain, a member of the cardiotonic steroid family, can activate a network of signaling molecules, and that NKA will also serve as a signal transducer that can provide a feedback loop between NKA and the mitochondria. This brief review summarizes the current knowledge and controversies with regard to the understanding of NKA signaling.
- Published
- 2016