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Glial tumours are a devastating, poorly understood condition carrying a gloomy prognosis for which clinicians sorely lack reliable predictive parameters facilitating a sound treatment strategy. Tp73, a p53 family member, expresses two main classes of isoforms--transactivatory activity (TA)p73 and DeltaTAp73--exhibiting tumour suppressor gene and oncogene properties, respectively. The authors examined their expression status in high- and low-grade adult gliomas. Isoform-specific real-time reverse transcription-polymerase chain reaction was used for the analysis of Tp73 isoform transcript expression in a series of 51 adult patients harbouring glial tumours, in order to compare tumour grades with each other, and with non-tumoural samples obtained from epileptic patients as well. Our data demonstrate increase of TAp73 and DeltaTAp73 transcript levels at onset and early stage of the disease. We also show that DeltaEx2-3 isoform expression in low-grade tumours anticipates clinical and imaging progression to higher grades, and correlates to the patients' survival. Expression levels of P1 promoter generated Tp73 isoforms--and particularly DeltaEx2-3--indeed allow for prediction of the clinical progression of low-grade gliomas in adults. Our data are the first such molecular biology report regarding low-grade tumours and as such should be of help for sound decision-making.

International audience; Si l'on admet que Michelet est avant tout un historien-penseur de la Nation, dont le travail et la réflexion sont résolument tendus vers la compréhension de la communauté sous le nom et les attributs de la Nation,-et si l'on se souvient que Michelet appartient à une époque qui va achever la promotion du territoire au rang de notion dominante pour penser, représenter et agir la communauté (et particulièrement la communauté nationale), on ne sera pas surpris que la question de l'espace soit chez lui au moins aussi importante que la question du temps. De fait, écrire l'histoire nationale oblige constamment Michelet à porter attention à la délimitation de l'espace, à son organisation, et peut-être surtout à son occupation.