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This review provides a summary of key findings from 27 systematic reviews of 51 articles first published or indexed during 2015, focusing on the treatment of psoriasis as well as precision medicine in psoriasis. Evidence supports weight loss interventions by dieting and exercise for the improvement in disease severity in overweight and obese patients with psoriasis. No significant increased risk of serious infections were reported for the biologic therapies adalimumab, etanercept and ustekinumab when compared with appropriate comparators. Evidence could not provide reliable estimates of rare adverse events, underscoring the need for large prospective registries. Polymorphisms in the tumour necrosis factor (TNF) alpha gene may confer improved responses to TNF inhibitor (TNFI) therapy, but studies to date lack power to detect true association. From limited available evidence, multidisciplinary management is both more effective and more satisfactory for patients with psoriasis and psoriatic arthritis than conventional consultations. This summary of reviews provides a succinct guide for clinicians and patients wishing to remain up?to?date with high quality evidence for the treatment of psoriasis.

Background Little is known about the influence of practice schedules on motor learning and skills transfer in children with and without developmental coordination disorder (DCD). Understanding how practice schedules affect motor learning is necessary for motor skills development and rehabilitation. Aims The study investigated whether active video games (exergames) training delivered under variable practice led to better learning and transfer than repetitive practice. Methods and procedures 111 children aged 6–10 years (M = 8.0, SD = 1.0) with no active exergaming experience were randomized to receive exergames training delivered under variable (Variable Game Group (VGG), n = 56) or repetitive practice schedule (Repetitive Game Group (RGG), n = 55). Half the participants were identified as DCD using the DSM-5 criteria, while the rest were typically developing (TD), age-matched children. Both groups participated in two 20 min sessions per week for 5 weeks. Outcomes and results Both participant groups (TD and DCD) improved equally well on game performance. There was no significant difference in positive transfer to balance tasks between practice schedules (Repetitive and Variable) and participant groups (TD and DCD). Conclusions and implications Children with and without DCD learn balance skills quite well when exposed to exergames. Gains in learning and transfer are similar regardless of the form of practice schedule employed. What this paper adds This is the first paper to compare the effect of practice schedules on learning in children with DCD and those with typical development. No differences in motor learning were found between repetitive and variable practice schedules. When children with and without DCD spend the same amount of time on exergames, they do not show any differences in acquisition of motor skills. Transfer of motor skills is similar in children with and without DCD regardless of differences in practice schedules.

This issue's agricultural articles pertain to a review of the Dominion experimental farms, the new standard flour in Canada, cultivating good pasture for cattle, conservation of soil fertility, beneficial birds, and the history of manufacturing margarine. The horticultural article outlines how to create a natural water garden. A Macdonald Institute student writes about how wartime rationing is affecting the French diet and an alumna continues her article regarding wartime food rations in France. The Query column answers agricultural queries send in by subscribers. Campus news addresses the success of the public speaking contest and the freshmen skating party. Athletic news reviews the athletic events of the year and includes a photograph of the inter-year hockey champions. The Macdonald column mentions the success of the junior dance and the women's basketball team. The Alumni column provides several military letters and alumni updates. The Dominion Experimental Farms The French woman and her bread Canada's standard flour Plugging the leaks The conservation of soil fertility Some feathered friends Modern oleomargarine technology A natural water garden Query The Awakening Editorial Alumni College life Athletics Macdonald Locals

This issue's agricultural articles pertain to Shorthorn Cattle, the profitability of increased crop production, and experimental work in weed eradication. Wartime articles address the necessity of increasing honey production due to the sugar shortage, utilizing skim milk and buttermilk as human food, the necessity of increasing hog production for feeding the army, and the formation of the Khaki University. The floriculture article is about growing flowers from seed. While the Query column answers agricultural queries. Campus news reports on the contribution of the Mac Hall girls, the demand for an increased livestock supply, the missionary conference of the Y. M. C. A., and that the athletic focus will be on hockey. The Macdonald column includes notes from the Y. W. C. A. meeting, and excitement over the term examinations. The Alumni column contains news of the war, alumni updates, and a military letter. The New Year Saving and using skimmilk and buttermilk as human food Produce more hogs Shorthorn Cattle The seed situation in Ontario Co-operative experiments in weed eradication Easily grown flowers from seed for the farm flower garden The Hour The necessity for increasing the honey crop Shot Without Warning Courcellette L'Erreur The Khaki University "Carry On" Editorial The Crucible of God Alumni Athletics College life Query Macdonald Locals

This issue's agricultural articles pertain to sending beef cattle to market early because of the grain shortage, tuberculin testing for cattle, potential for increasing the honey industry, the success of the farm power course, prospects for poultry and egg production in 1918, and plant breeding at the Vineland Experiment Station. Other articles include encouraging farmers to produce quality products, the Silver Black Fox industry, banana production in the tropics, the ornithology of winter birds, and agricultural education through motion pictures. A Macdonald Institute student contributed an article on designing the ideal kitchen. While the Query column answers agricultural queries send in by subscribers. The editorial comments on the dignity of the agriculturalist. Campus news provides a summary of the activities of each of the campus clubs, and results of the hockey and basketball games. The Macdonald column mentions the women's initiation and the success of the promenade. The Alumni column provides several military letters and alumni updates. Finished beef cattle The Silver Black Fox in captivity Tuberculosis of cattle and the tuberculin test What the Motion Picture Bureau hopes to do in Ontario agriculture Quality as well as quantity Possibilities of the honey industry in Ontario Farm power course The ideal kitchen The banana Winter birds Poultry and egg production for 1918 Plant breeding at the Horticultural Experiment Station, Vineland A Soliloquy Query Editorial Alumni College life Athletics Macdonald Locals

The theme of the agricultural articles in this issue relate to agricultural education in rural schools. Articles range from practical work to school gardening and beekeeping. Other agricultural articles pertain to bacteriology and potato grading. The campus articles focus on the Summer School and each of the college departments provides a short report on their work. The Query column answers agricultural queries send in by subscribers. Campus news also reports the successful visit of the Governor General and Duchess of Devonshire. The Macdonald Institute column features activities of the graduating class and lists their employment prospects. The Alumni column provides several military letters, marriage announcements, and alumni updates. Practical work and a liberal education Bacteriology in relation to agriculture Household science in rural schools school gardening O. A. C. summer school The school teacher-beekeeper Grade your potatoes Query Editorial The College Departments From the Butterfly's Standpoint Alumni Macdonald College life Locals

Only portions of the articles in this issue are available. The agricultural articles address the relationship of plant physiology to agriculture, war and agriculture, the market for Ontario fruit in Western Canada, and the Caledon Township results of the Farm Management Survey. One student provides her impressions of being a Farmerette. Barbara Smith continues her short story. The Editorial contains several photographs showing the summer campus preparations. The Macdonald Institute column features articles on the Farmerettes who are the first women admitted into the short course in agriculture. The Alumni column provides several military letters, the addresses of the graduating class, and alumni updates. The relationship of plant physiology to agriculture Impressions of a farmerette War and agriculture Daisy in the Dairy The western market for Ontario fruit Results of Farm Management Survey Through Consecration - Victory Editorial Alumni Macdonald Trials and tribulations

This expanded issue contains agricultural articles regarding Aberdeen Angus cattle, improving the profitability of poultry production, results of the O. A. C. livestock sale, neglect of the farm apple orchard, a report on the Conference of Potato Growers, and an outline of the stock judging trip by the senior class. Other articles include the advent of powered milk, how to increase Canada's food supply, the potential in farming in Western Canada, and famous Christmas days in Canadian history. This issue printed the winners of the O. A. C. Review's competition in short stories, poetry, photographs, and cartoons. Wartime articles include the rules and regulations of sending food to prisoners of war, and tile drainage during wartime. Campus news reports on the new Union Government's immigration bill, the success of the production of The Cricket on the Hearth, and the results of the athletic teams for rugby, baseball, basketball, and track. The reinstituted Query column answers agricultural queries. The Macdonald column reports on the creation of a chapter of the Daughters of the Empire, and women's tennis tournament results. The Alumni column is extensive in this issue with the listing of the Honor Roll, a list of the alumni killed in the war, and the military addresses of the seniors on active service. The Aberdeen Angus as a breed The personal factor in poultry-keeping Christmas Live stock sale at the O. A. C. Germs Christmas days famous in Canadian history Rules and regulations regarding the sending of food to prisoners of war Powdered milk Tile drainage in wartime Another side of greater efficiency The future of the farm apple orchard Report of Conference of Potato Growers and Specialists Notes on Western Canada Stock judging by fourth year "Ag." men Editorial Go, My Son! Alumni A Yule-tide Greeting College life Athletics Query Macdonald Locals

This issue's agricultural articles pertain to the sheep industry in Canada, a Massey Hall lecture on better farm machinery due to the farm labour shortage, and horticulture in Northern Ontario. A Macdonald Institute student contributes an article on the duties of a wartime nurse in the Red Cross Voluntary Aid Detachment. In addition, there are short stories by Barbara Smith and George Hood. The Query column answers, agricultural queries send in by subscribers. Campus news addresses the results of the college elections, a report on the Dairy Conference at the O. A. C., and the examination results. The Editorial staff extend a welcome to the women studying at the O. A. C. - the Farmerettes. The Macdonald column extols the graduates to acquit themselves nobly, to practice food conservation, and an update on the activities of the I. O. D. E. This issue features a special column devoted to Macdonald alumnae and the work they have undertaken. The Alumni column provides several military letters, lists the positions of alumni who work at the O. A. C., and alumni updates. The sheep raising industry in Canada The V. A. D.! Who is she? In Hospital Better farm machinery Where Are You Going, My Pretty Maid Practical horticulture in Northern Ontario In Simmer Training Query Editorial Alumni College life Macdonald Macdonald alumnae Macdonald locals

This issue's agricultural articles include a history of the field drainage work conducted at the O. A. C., a tour of Craighleigh in Toronto, mosaic disease in potatoes, a report on the Mule foot Hog, and a report on the Annual Meeting of the Canadian Seed Growers' Association. Three agricultural articles focus on dairy production, they include, augmenting farm income with intensive dairying methods, the O. A. C.'s improvement of dairy cattle, and testing dairy cattle in Ontario for their milk yield. This issue's poultry article is on increasing poultry production due to high demand. Campus news contains an article on cramming for examinations, the production of The Cricket on the Hearth, and the uncertain outlook for the 1917 rugby season. The editorial continues the debate on continuing the hospital co-operative, a welcome to the new students, and suggestions on how to excel at college. The Alumni column features updates of the class of 1917, marriage announcements, and updates on military service. This issue does not include a Macdonald column. Selection in poultry "Interlude" Extensive dairying as a sideline The outlook for the improvement of dairy cattle Drainage retrospect and prospect Craighleigh hath charms The mosaic disease of potatoes Cow-testing in Ontario "Cram" considered The Mule-foot Hog Annual Meeting of Canadian Seed Growers' Association Editorial College life Alumni Athletics Locals

This month's articles pertain to the loneliness of being a rural teacher, providing agricultural journalism beyond college, encouraging rural educators to support their school fair, and whether the study of French is necessary at the college. Agricultural articles address the success of the wool sales for the Ontario Farmers' Co-operative, observing the hidden worlds of wildlife, the profitability of growing alfalfa, and instructions on building a septic tank for the farm. This issue also contains another short story by Barbara Smith. The Macdonald Institute article outlines the value of the short course. The Alumni column provides several military letters, marriage announcements, and alumni updates. Keeping alive Agricultural journalism The study of French at the O. A. C. Puzzled Propagandists The septic tank The Ontario Farmers' Co-operative wools sale Hidden worlds The school fair Why grow alfalfa Editorial Alumni Macdonald advertising

This issue's agricultural articles address the unprofitability of poultry diseases, the Farm Management Survey, the 1917 corn crop in Western Ontario, prospects of farming as an occupation, the economics of food waste, and purchasing winter cattle feed. There is a wartime article regarding the Organization of Resources Committee. Campus articles include a welcome from the Union Literary Society and news regarding the student labor issue, and the initiation of new students. The Macdonald column reports on the Mac Hall initiation. Alumni news contains alumni news of the war, alumni updates, and a military letter. The work of the Organization of Resources Committee Poultry diseases responsible for big national loss The Farm Management Survey Western Ontario's 1917 corn crop Annual Review competition A Thankful Heart! The handling of celery Farming as an occupation "Pernambuco next stop!" The Union Literary Society If waste were eliminated Buying cattle feeds for winter use Editorial Alumni Athletics College life Locals Macdonald

This issue's agricultural articles pertain to the need to export surplus dairy products to foreign markets, the winter care of sheep, cold storage of fruit, improving egg production with a protein diet, feeding cattle destined for market, and the quality of butter. The editorial addresses the new conscription law and military exemption. Campus new reports on the various student receptions, the At Home promenade, the Union Literary Society meeting, and the field day results. The Macdonald column highlights the endeavors of the Macdonald class of 1917. The Alumni column features a military diary by George Spencer, as well as, marriage announcements, and updates on military service. The export dairy trade Winter care of sheep Precooling and cold storage of fruits Protein for laying hens Feeding stockers A passing art The Soldier's Idol Editorial Alumni Athletics College life Macdonald Locals

The theme of this issue is regarding seeds and potato production. Agricultural articles address seed supply and maximizing the yield from seed crops. Articles that pertain to potatoes relate to potato diseases and profitability of growing potatoes in Northern Ontario. The Query column answers agricultural queries send in by subscribers. Campus news provides a summary of the activities of athletic endeavors, the theatre production of Queen Esther, and meetings of the Live Stock Club and Horticulture Club. The Macdonald column has an article on friendly criticism, observations of the I. O. D. E. dance, and a letter from an alumna regarding wartime food rations in France. The Alumni column provides several military letters and alumni updates for individuals who had competed in livestock judging competitions. Vegetable seed growing in Ontario Seed potatoes in relation to disease Yield and quality of grain crops Seed potato situation in Northern Ontario Good seed and the vegetable grower The Experimental Union as a source of good seed supply The development of a seed Home grown mangel seed Seed selection The honey bee in relation to fruit and seed production Cleaning seed grain Birds as weed seed destroyers Margarine Query Editorial Alumni College life Athletics Macdonald