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Renal cell carcinoma is a rare pediatric malignant tumor of the kidney. Unlike Wilms tumor, the efficacy of chemotherapy and radiation therapy in pediatric renal cell carcinoma remains uncertain. Surgery is the best treatment and prognosis is favorable when the tumor is localized and completely eradicated. We report an exceptional observation in a 7-year-old girl with renal cell carcinoma who had been treated 20 months previously for Ewing sarcoma with chemotherapy and radiotherapy. The renal tumor was revealed by abdominal pain without hematuria. She underwent a radical nephrectomy, and histopathology concluded in renal carcinoma associated with translocation Xp 11.2 grade 3 of Furhrman pT3a N1. No adjuvant therapy was given. After 3 years of follow-up, there is no evidence of local or metastatic recurrence. This observation is significant given the very young age of this patient, the occurrence after Ewing sarcoma with a short disease-free interval. It seems that translocation renal cell carcinoma is associated with previous exposure to chemotherapy, particularly topoisomerase II inhibitors or alkylating agents.

Summary Background Bloom syndrome is a rare disease characterized by chromosomal instability and increased risk of developing lymphoma. Observation We report on a case of Bloom syndrome in a 5-year-old boy with Burkitt lymphoma. The diagnosis was suspected by growth retardation, repeated respiratory infections, facial telangiectasia, and a low immunoglobulin level, then confirmed cytogenetically by sister chromatid exchanges. Chemotherapy was poorly tolerated, which required reducing the doses. Unfortunately, it was not sufficient to control the neoplasm and the patient died 14 months after diagnosis. Conclusions Cancers in Bloom syndrome are a challenge since the potentially life-threatening side effects of the chemotherapy may require modifications in standard treatment such as dose reduction, which can compromise the tumor prognosis.

Renal cell carcinoma is a rare pediatric malignant tumor of the kidney. Unlike Wilms tumor, the efficacy of chemotherapy and radiation therapy in pediatric renal cell carcinoma remains uncertain. Surgery is the best treatment and prognosis is favorable when the tumor is localized and completely eradicated. We report an exceptional observation in a 7-year-old girl with renal cell carcinoma who had been treated 20 months previously for Ewing sarcoma with chemotherapy and radiotherapy. The renal tumor was revealed by abdominal pain without hematuria. She underwent a radical nephrectomy, and histopathology concluded in renal carcinoma associated with translocation Xp 11.2 grade 3 of Furhrman pT3a N1. No adjuvant therapy was given. After 3 years of follow-up, there is no evidence of local or metastatic recurrence. This observation is significant given the very young age of this patient, the occurrence after Ewing sarcoma with a short disease-free interval. It seems that translocation renal cell carcinoma is associated with previous exposure to chemotherapy, particularly topoisomerase II inhibitors or alkylating agents.

Materno foetal infection (MFI) remains one of the major causes of neonatal morbidity and mortality. Early detection of neonatal sepsis can be difficult, because the first signs of the disease may be unspecific and similar to symptoms of other non-infectious processes.We aimed to investigate the role of procalcitonin (PCT) in the diagnosis of fetal infection (MFI), and to compare it with those of the C-reactive protein (CRP).We have conducted a prospective study during 20 months: which concerned 25 newborns suspected of MFI and admitted before 12 hours of life. All newborn had anamnestic and/or physical signs of possible infection. MFI was confirmed in newborns with positive bacterial analysis. CRP and PCT were determined in the sera at H12, H24, H36 and H48. Newborns were divided into: patients with recognized MFI (group 1), patients with possible MFI (group2) and non infected newborns (group 3):The specificity of PCT was 80% versus 27% for the CRP. Negative predictive value of PCT was 85% versus 66% for the CRP. The mean values, at H12, H24, H36 and H48, of PCT for newborn who had MFI were statistically grater than those for no infused group (p0.05). No statistical difference was observed concerning CRP values.PCT may a useful tool in early diagnosing of MFI; it has better specificity and negative predictive value than CRP.

Objectifs Etudier a travers une serie de 32 nephrolastomes suivis a l’unite d’oncologie de l’Hopital d’enfants de Tunis, les caracteristiques epidemiologiques et cliniques de cette tumeur ainsi que les resultats therapeutiques. Patients et Methodes Il s’agit d’une etude prospective ayant collige 32 cas de nephroblastome entre le 1 er avril 2005 et le 31 decembre 2009. Le diagnostic de nephroblastome a ete retenu sur l’examen anatomopthologique de la piece operatoire. Le protocole therapeutique utili se est celui du groupe franco-africain d’oncologie pediatrique. Resultats Il existe une predominance feminine (sex ratio : 0,36). L’âge moyen de nos patients est de 3 ans et demi. Le bilan d’extension a objective des metastases chez 6 patients. Il existait dans notre serie une predominance des stades I (63 %). L’histologie etait intermediaire dans 80 % des cas, a haut risque dans 20 % des cas. Apres un recul moyen de 15mois, l’evolution a ete favorable dans 80 % des cas. Les rechutes sont survenues dans 3 cas. On a recense dans cette serie 6 deces (20 %). Conclusion Notre serie se distingue par la predominance des stades I, le pourcentage assez important d’histologie a haut risque et un faible nombre des perdus de vue. Nous soulignons la faisabilite des protocoles Europeens dans notre unite.