544 results on '"F Calvo"'
Search Results
2. Informative social interactions
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Luc Arrondel, Hector F. Calvo Pardo, Chryssi Giannitsarou, Michael Haliassos, Giannitsarou, Chryssi [0000-0002-1488-2433], and Apollo - University of Cambridge Repository
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History ,Organizational Behavior and Human Resource Management ,Economics and Econometrics ,Polymers and Plastics ,jel:D84 ,jel:C42 ,jel:D83 ,jel:D12 ,Subjective expectations ,Social interactions ,Industrial and Manufacturing Engineering ,jel:G11 ,D83 ,D84 ,Peer effects ,Household finance ,Portfolio choice ,ddc:330 ,Information networks ,social interactions ,D12 ,G11 ,Business and International Management ,C42 - Abstract
Household finances are confidential and discussions are limited to a subset of peers. We collect novel representative survey data to examine separately whether interactions with inner and outer social circles influence return perceptions, expectations, and exposure to a widely known financial instrument in a developed economy with multiple information sources. We find that a respondent's connectedness, proxied by perceived prevalence of information or participation in the small financial circle, improves expectation accuracy indirectly, through boosting accuracy of perceived past returns; and influences stock participation and exposure not only by influencing expectations, but also directly.
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- 2022
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3. A simplified echocardiographic formula to estimate cardiac index in the intensive care unit
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D Romagnolo, C Gaspardone, L Baldetti, A Fasolino, B Peveri, F Calvo, M Gramegna, V Pazzanese, S Sacchi, A Beneduce, G Fiore, L Rampa, S Ajello, and A M Scandroglio
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General Medicine ,Cardiology and Cardiovascular Medicine ,Critical Care and Intensive Care Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background Measurement of cardiac index (CI) is crucial in the hemodynamic assessment of critically ill patients. Pulmonary artery catheterization (PAC) remains the gold standard for CI evaluation, but it's invasive. Doppler trans-thoracic echocardiography (TTE) has been proposed as an accurate bedside non-invasive alternative to PAC for CI estimation, based on measurement of left ventricular outflow tract velocity time integral (LVOT-VTI) and diameter (LVOT-d). However, intrinsic limits of geometrical assumptions and practical limitations related to the intensive care unit (ICU) setting may lead to inaccurate CI calculation, mainly due to errors in LVOT-d. A body surface area (BSA)-based formula to predict LVOT-d has been proposed and validated. Including the predicted LVOT-d in the CI equation we obtained a new "simplified formula" for TTE CI estimation: CI=2,17*LVOT-VTI*HR/1000. Purpose This study aimed to assess the accuracy of a new TTE-based simplified formula, only requiring LVOT-VTI and HR, for TTE estimation of CI. Methods We prospectively enrolled all consecutive patients admitted to the ICU requiring PAC from January to December 2021 (n=74). We measured TTE-based CI method using both the "traditional formula" (traditional CI TTE) and the new "simplified formula" (simplified CI TTE), and compared the accuracy of both with the PAC-derived CI (CI PAC) as the reference method. Results As shown in Figure 1a, there was a moderate correlation (r = 0.70, p < 0.001) between traditional CI TTE and the CI PAC. A plot of the differences between traditional CI TTE and the CI PAC is illustrated in Figure 2a, resulting in a mean difference of -0.18 ± 0.58 L/min/m2, and 95% limits of agreement of -1.32 to +0.96 L/min/m2. The correlation between simplified CI TTE and CI PAC was strong (r = 0.81, p < 0.001) (Figure 1b) and resulted significantly greater than the traditional CI TTE and CI PAC correlation (p < 0.05). On Bland-Altman plot analysis (Figure 2b), the mean difference between simplified CI TTE and CI PAC was +0.19 ± 0.48 L/min/m2 with 95% limits of agreement of -0.74 to +1.13 L/min/m2. Conclusion In this study, we validated an easy-to-use and practical approach, leveraging on TTE LVOT-VTI and HR only, for non-invasive estimation of CI in ICU patients. In this peculiar setting, our formula was more reliable than the traditional CI TTE formula. However, despite the strong correlation with CI PAC, our formula introduces a slight but systematic overestimation of CI (+0.19 L/min/m2), as illustrated in the Bland-Altman plot. Therefore, this formula may be particularly useful in longitudinal CI assessment rather than precisely quantifying CI on a single measurement. This approach may thus be apt to quickly assess the hemodynamic response to pharmacological and mechanical supports during longitudinal assessment.
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- 2023
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4. Solar oxygen abundance using SST/CRISP center-to-limb observations of the O I 7772 \r{A} line
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A. G. M. Pietrow, R. Hoppe, M. Bergemann, and F. Calvo
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Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,Astronomy and Astrophysics - Abstract
Solar oxygen abundance measurements based on the O I near-infrared triplet have been a much-debated subject for several decades since non-local thermodynamic equilibrium (NLTE) calculations with 3D radiation-hydrodynamics model atmospheres introduced a large change to the 1D LTE modelling. In this work, we aim to test solar line formation across the solar disk using new observations obtained with the SST/CRISP instrument. The observed dataset is based on a spectroscopic mosaic stretching from disk center to the solar limb. By comparing the state-of-the-art 3D NLTE models with the data, we find that the 3D NLTE models provide an excellent description of line formation across the disk. We obtain an abundance value of $A(\mathrm{O}) = (8.73 \pm 0.03)$ dex, with a very small angular dispersion across the disk. We conclude that spectroscopic mosaics are excellent probes for geometric and physical properties of hydrodynamics models and non-LTE line formation., Comment: Accepted in A&A
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- 2023
5. Desarrollo de un sistema de clasificación de imágenes digitales para medir la humedad en granos de café
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Yurley T. Tovar, Andrés F. Calvo, and Arley Bejarano
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General Energy ,Strategy and Management ,Geotechnical Engineering and Engineering Geology ,Industrial and Manufacturing Engineering ,Computer Science Applications ,Food Science - Published
- 2022
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6. Supplementary Data from Radiosensitization of Epidermal Growth Factor Receptor/HER2–Positive Pancreatic Cancer Is Mediated by Inhibition of Akt Independent of Ras Mutational Status
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Carolyn I. Sartor, Janiel M. Shields, Joel E. Tepper, Benjamin F. Calvo, Kathryn M. Baerman, Adrienne D. Cox, Angelina V. Vaseva, and Randall J. Kimple
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Supplementary Data from Radiosensitization of Epidermal Growth Factor Receptor/HER2–Positive Pancreatic Cancer Is Mediated by Inhibition of Akt Independent of Ras Mutational Status
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- 2023
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7. Data from Radiosensitization of Epidermal Growth Factor Receptor/HER2–Positive Pancreatic Cancer Is Mediated by Inhibition of Akt Independent of Ras Mutational Status
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Carolyn I. Sartor, Janiel M. Shields, Joel E. Tepper, Benjamin F. Calvo, Kathryn M. Baerman, Adrienne D. Cox, Angelina V. Vaseva, and Randall J. Kimple
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Purpose: Epidermal growth factor receptor (EGFR) family members (e.g., EGFR, HER2, HER3, and HER4) are commonly overexpressed in pancreatic cancer. We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provide evidence in support of further clinical investigations.Experimental Design: Expression of EGFR family members in pancreatic cancer lines was assessed by quantitative reverse transcription-PCR. Cell growth inhibition was determined by MTS assay. The effects of inhibition of EGFR family receptors and downstream signaling pathways on in vitro radiosensitivity were evaluated using clonogenic assays. Growth delay was used to evaluate the effects of nelfinavir on in vivo tumor radiosensitivity.Results: Lapatinib inhibited cell growth in four pancreatic cancer cell lines, but radiosensitized only wild-type K-ras–expressing T3M4 cells. Akt activation was blocked in a wild-type K-ras cell line, whereas constitutive phosphorylation of Akt and extracellular signal-regulated kinase (ERK) was seen in lines expressing mutant K-ras. Overexpression of constitutively active K-ras (G12V) abrogated lapatinib-mediated inhibition of both Akt phosphorylation and radiosensitization. Inhibition of MAP/ERK kinase/ERK signaling with U0126 had no effect on radiosensitization, whereas inhibition of activated Akt with LY294002 (enhancement ratio, 1.2-1.8) or nelfinavir (enhancement ratio, 1.2-1.4) radiosensitized cells regardless of K-ras mutation status. Oral nelfinavir administration to mice bearing mutant K-ras–containing Capan-2 xenografts resulted in a greater than additive increase in radiation-mediated tumor growth delay (synergy assessment ratio of 1.5).Conclusions: Inhibition of EGFR/HER2 enhances radiosensitivity in wild-type K-ras pancreatic cancer. Nelfinavir, and other phosphoinositide 3-kinase/Akt inhibitors, are effective pancreatic radiosensitizers regardless of K-ras mutation status. Clin Cancer Res; 16(3); 912–23
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- 2023
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8. Paying or Being Paid to Be Green?
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Hector F. Calvo Pardo, Rupali Vashisht, and Jose Olmo
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2023
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9. (425) Myocardial Metabolic Positron Emission Tomography for Viability Assessment During Impella Support
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L. Baldetti, G. Barone, M. Gramegna, V. Pazzanese, S. Sacchi, F. Calvo, S. Ajello, E. Busnardo, and M. Scandroglio
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Pulmonary and Respiratory Medicine ,Transplantation ,Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2023
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10. Time until modification of antiparkinsonian therapy in a group of patients from Colombia
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A, Valencia-Vásquez, A, Gaviria-Mendoza, J D, Ayala-Torres, F, Calvo-Torres, and J E, Machado-Alba
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The aim was to determine the time elapsed between the start of treatment with antiparkinsonian agents and the modification of the pharmacological therapy, and to establish its related factors, in a group of patients with Parkinson's disease from Colombia.Retrospective cohort study that collected information about the treatment of patients with Parkinson's disease who started drug therapy between June, 2011 and December, 2013; a five-year follow-up was performed. Survival analyses for time to therapy modification were generated, and factors related to these changes were determined using Cox regression models.A total of 3,224 patients (51.8% men) with a mean age of 73.1 ± 13.5 years started treatment with antiparkinsonian agents. After five years, 2,046 patients (63.5%) had modifications in drug therapy, in a mean time of 36.4 months (95% confidence interval: 35.7-37.1). A total of 1,216 patients (37.8%) required the addition of another active principle, while 830 (25.7%) had a switch to another drug. In the multivariate analysis, male sex, age over 65 years, and the start of amantadine were identified as factors that increased the likelihood of therapy modification. The use of bromocriptine, biperiden, and monotherapy as an initial treatment were associated with a reduction in this likelihood.After five years of treatment, 63.5% of the patients with Parkinson's disease required modifications to their therapy, with a mean time of three years. Male sex, age over 65 years, and receiving initial therapy with amantadine affected the likelihood of switching therapy in these patients in Colombia.Tiempo hasta la modificación de la terapia antiparkinsoniana en un grupo de pacientes de Colombia.Introducción. Se buscó determinar el tiempo transcurrido desde el inicio del tratamiento con fármacos antiparkinsonianos hasta la modificación en la terapia y establecer sus factores relacionados en un grupo de pacientes con enfermedad de Parkinson de Colombia. Pacientes y métodos. Estudio de cohorte retrospectiva que recolectó información sobre el tratamiento de pacientes con enfermedad de Parkinson que iniciaron terapia farmacológica entre junio de 2011 y diciembre de 2013; se realizó seguimiento a cinco años. Se generaron análisis de sobrevida para el tiempo trascurrido hasta la modificación de la terapia y se determinaron los factores relacionados con estos cambios utilizando modelos de regresión de Cox. Resultados. Un total de 3.224 pacientes (51,8%, hombres), con edad media de 73,1 ± 13,5 años, iniciaron tratamiento con fármacos antiparkinsonianos. Después de cinco años, 2.046 pacientes (63,5%) tuvieron modificaciones en la terapia farmacológica, con un promedio de tiempo de 36,4 meses (intervalo de confianza al 95%: 35,7-37,1). Un total de 1.216 pacientes (37,8%) requirió adición de otro principio activo, mientras que 830 (25,7%) tuvieron un cambio por otro medicamento. En el análisis multivariado, el sexo masculino, la edad mayor de 65 años y el inicio de amantadina se identificaron como factores que aumentaron la probabilidad de modificar la terapia. El uso de bromocriptina y biperideno, y la monoterapia como tratamiento inicial redujeron dicho riesgo. Conclusión. Después de cinco años de tratamiento, el 63,5% de los pacientes con enfermedad de Parkinson requirió modificaciones de la terapia, con un tiempo promedio de tres años. El sexo masculino, la edad mayor de 65 años y recibir terapia inicial con amantadina afectaron a la probabilidad de cambio de terapia en estos pacientes en Colombia.
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- 2022
11. Center-to-limb variation of spectral lines and continua observed with SST/CRISP and SST/CHROMIS
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A. G. M. Pietrow, D. Kiselman, O. Andriienko, D. J. M. Petit dit de la Roche, C. J. Díaz Baso, and F. Calvo
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Earth and Planetary Astrophysics (astro-ph.EP) ,Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,FOS: Physical sciences ,Astronomy and Astrophysics ,Solar and Stellar Astrophysics (astro-ph.SR) ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Observations of center-to-limb variations (CLV) of spectral lines and continua provide a good test for the accuracy of models of solar and stellar atmospheric structure and spectral-line formation. They are also widely used to constrain elemental abundances and are becoming increasingly important in atmospheric studies of exoplanets. However, only a few such data sets exist for chromospheric lines. We aim to create a set of standard profiles by means of mosaics made with the CRISP and CHROMIS instruments of the Swedish 1-m Solar Telescope (SST), as well as to explore the robustness of said profiles obtained using this method. For each spectral line we use a mosaic that ranges from the center to the limb. Each of these mosaics are averaged down to 50 individual spectral profiles, spaced by 0.02 in the $\mu$ scale. These profiles are corrected for p-mode oscillations, and their line parameters (equivalent width, line shift, full-width at half-maximum, and line depth) are then compared against literature values where possible. We present a set of 50 average profiles that are spaced equidistantly along the cosine of the heliocentric angle ($\mu$) by steps of 0.02 for five continuum points between 4001 and 7772 \AA, as well as ten of the most commonly observed spectral lines at the SST (Ca II H & K, H$\beta$, Mg I 5173 \AA, C I 5380 \AA, Fe I 6173 \AA, Fe I 6301 \AA, H$\alpha$, O I 7772 \AA, and Ca II 8542 \AA). Center-to-limb variation of line profiles and continua are shared in the CDS as machine-readable tables; providing a quantitative constraint on theoretical models that aim to model stellar atmospheres., Comment: Published in A&A. CLV data is available in the CDS
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- 2022
12. Aortic and vascular involvement in Loeys-Dietz Syndrome. Results from the REPAG registry (Spanish network of genetic aortic diseases)
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G Teixido Tura, D Martinez, F Calvo, R Garcia-Orta, R Sanchez, J M Larranaga, A Hernandiz, E Diaz, E Montanes, F Cabrera, A Sabate, F Nistal, A Forteza, and A Evangelista
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Cardiology and Cardiovascular Medicine - Abstract
Background LDS is a rare disease due to genetic variants in the TGFB pathway. Limited information is available regarding the overall aortic and vascular outcome of these patients Purpose To evaluate aortic and vascular complications of patients with mutations in the TGFB pathway. Methods Retrospective longitudinal study including patients with (likely) pathogenic (LP/P) variants in the TGFbeta pathway from 10 tertiary centers. Clinical and imaging data were reviewed and data on aortic and vascular outcome included. Results A total of 163 patients were included (47.9% women, 38.6% index cases), mean age at first evaluation 32.3±20.4 years, 27.0% with age During a mean follow-up of 4.7±3.7 years, 54 (33.1%) patients had at least 1 aortic surgery (max 6). Mean age at first aortic surgery was 37.2±16.8 years (Range 1.2–72.9). First surgery was elective in 42 (77.8%), and included aortic root or ascending aorta in 40 (95.2%) and isolated descending aorta in 2 (4.8%). Emergent surgery included aortic root or ascending aorta in 11 (92.7%). Ascending aorta-root diameter previous to elective surgery was 48.9±4.9mm (range 41–65). 7 patients died during follow-up (2 intracranial bleeding, 1 SD, 2 aortic ruptures, 1post aortic surgery, 1 non-CV). Furthermore, 19 acute aortic syndromes (AAS) were reported (17 dissections, 2 haematomas) in 18 patients, 10 type A (52.6%). Mean age at first AAS was 42.3±11.1 years (min 19.7 years to 62.9 years) Median survival free of intervention, dissection or death was 57.1 years, being worst for men than women (44.7 yrs vs 69.1 years, p Conclusions In patients with Loeys-Dietz Syndrome, there's a high prevalence of aortic surgeries and acute aortic events, with high numbers of peripheral and intracranial aneurysms. A worst prognosis in men than in women is observed in TGFBR1 and SMAD3 variants. Thus, specialized clinical and imaging follow-up is crucial in the management of these patients Funding Acknowledgement Type of funding sources: None.
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- 2022
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13. Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry
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Pazdernik, Michal, Iung, Bernard, Mutlu, Bulent, Alla, François, Riezebos, Robert, Kong, William, Nunes, Maria Carmo Pereira, Pierard, Luc, Srdanovic, Ilija, Yamada, Hirotsugu, de Martino, Andrea, Miglioranza, Marcelo Haertel, Magne, Julien, Piper, Cornelia, Laroche, C. cile, Maggioni, Aldo P., Lancellotti, Patrizio, Habib, Gilbert, Selton-Suty, Christine, Ronderos, R., Avegliano, G., Oses, P. Fernandez, Filipini, E., Granada, I., Iribarren, A., Mahia, M., Nacinovich, F., Ressi, S., Obregon, R., Bangher, M., Dho, J., Cartasegna, L., Plastino, M. L., Novas, V., Shigel, C., Reyes, G., de Santos, M., Gastaldello, N., Fernandez, M. Granillo, Potito, M., Streitenberger, G., Velazco, P., Casabé, J. H., Cortes, C., Guevara, E., Salmo, F., Seijo, M., Weidinger, F., Heger, M., Brooks, R., Stöllberger, C., Ho, C. Y., Perschy, L., Puskas, L., Goliasch, G., Binder, C., Rosenhek, R., Schneider, M., Winter, M. P., Hoffer, E., Melissopoulou, M., Lecoq, E., Legrand, D., Jacquet, S., Massoz, M., Lancellotti, P., Pierard, L., Dulgheru, R., Marchetta, S., D´Emal, C., Oury, C., Cosyns, B., Droogmans, S., Kerkhove, D., Motoc, A., Plein, D., Roosens, B., Soens, L., Weytjens, C., Lemoine, I., Rodrigus, I., Paelinck, B., Amsel, B., Unger, P., Konopnicki, D., Beauloye, C., Pasquet, A., Pierard, S., Vancraeynest, D., Vanoverschelde, J. L., Sinnaeve, F., Andrade, J. L., Rodrigues, A. C. Tude, Staszko, K., Dos Santos Monteiro, R., Miglioranza, M. H., Shuha, D. L., Alcantara, M., Cravo, V., Fazzio, L., Felix, A., Iso, M., Musa, C., Siciliano, A. P., Filho, F. Villaca, Braga, J., Rodrigues, A., Silva, R., Vilela, F., Rodrigues, D., Silva, L., Morhy, S., Fischer, C., Vieira, M., Afonso, T., Abreu, J., Falcao, S. N., Moises, V., Gouvea, A., João, G., Mancuso, F., Silva, C., Souza, A. C., Abboud, C. S., de Mattos Barretto, R. Bellio, Ramos, A., Arnoni, R., Assef, J. E., Togna, D. J. Della, le Bihan, D., Miglioli, L., Oliveira, A. P. Romero, Kroll, R. Tadeu Magro, Cortez, D., Gelape, C. L., Nunes, M. d. C. Peirira, de Abreu Ferrari, T. C., Chan, K. L., Hay, K., le, V., Page, M., Poulin, F., Sauve, C., Serri, K., Mercure, C., Beaudoin, J., Pibarot, P., Sebag, I., Rudski, L., Ricafort, G., Barsic, B., Krajinovic, V., Vargovic, M., Separovic-Hanzevacki, J., Lovric, D., Reskovic-Luksic, V., Vincelj, J., Jurinjak, S. Jaksic, Yiannikourides, V., Ioannides, M., Kyriakou, C., Pofaides, C., Masoura, V., Yiangou, K., Pudich, J., Linhart, A., Siranec, M., Marek, J., Blechova, K., Kamenik, M., Pazdernik, M., Pelouch, R., Coufal, Z., Mikulica, M., Griva, M., Jancova, E., Mikulcova, M., Taborsky, M., Precek, J., Jecmenova, M., Latal, J., Widimsky, J., Butta, T., Machacek, S., Vancata, R., Spinar, J., Holicka, M., Long, F. Pow Chon, Anzules, N., Carpio, A. Bajana, Largacha, G., Penaherrera, E., Moreira, D., Mahfouz, E., Elsafty, E., Soliman, A., Zayed, Y., Aboulenein, J., Abdel-Hay, M., Almaghraby, A., Abdelnaby, M., Ahmed, M., Hammad, B., Saleh, Y., Zahran, H., Elgebaly, O., Saad, A., Ali, M., Zeid, A., Sharkawy, R. El, Meshaal, M., Al Kholy, A., Doss, R., Osama, D., Rizk, H., Elmogy, A., Mishriky, M., Assayag, P., Hatimi, S. El, Botelho-Nevers, Saint- E., Campisi, S., Fuzellier, J. F., Gagneux-Brunon, A., Pierrard, R., Tulane, C., Detoc, M., Mehalla, T., Boutoille, D., Al Habash, O., Asseray-Madani, N., Biron, C., Brochard, J., Caillon, J., Cueff, C., le Tourneau, T., Lecompte, A. S., Lecomte, R., Lefebvre, M., Michel, M. M. Magali, Pattier, S., Delarue, S., le Bras, M., Orain, J., Faucher, J. F., Aboyans, V., Beeharry, A., Durox, H., Lacoste, M., Magne, J., Mohty, D., David, A., Pradel, V., Sierra, V., Neykova, A., Bettayeb, B., Elkentaoui, S., Tzvetkov, B., Landry, G., Strady, C., Ainine, K., Baumard, S., Brasselet, C., Tassigny, C., Valente-Pires, V., Lefranc, M., Hoen, B., Lefevre, B., Curlier, E., Callier, C., Fourcade, N., Jobic, Y., Ansard, S., le Berre, R., le Roux, P., le Ven, F., Pouliquen, M. C., Prat, G., Bouchart, F., Savoure, A., Alarcon, C., Chapuzet, C., Gueit, I., Tribouilloy, C., Bohbot, Y., Peugnet, F., Gun, M., Iung, B., Duval, X., Lescure, X., Ilic-Habensus, E., Sadoul, N., Selton-Suty, C., Alla, F., Chevalier, E., Goehringer, F., Huttin, O., Garcia, R., le Marcis, V., Tattevin, P., Donal, E., Flecher, E., Revest, M., Habib, G., Hubert, S., Casalta, J. P., Gouriet, F., Arregle, F., Cammilleri, S., Tessonnier, L., Riberi, A., Chirouze, C., Bouiller, K., Brunel, A. S., Fournier, D., Hustache-Mathieu, L., Klopfenstein, T., Moreau, J., Lim, P., Oliver, L., Ternacle, J., Moussafeur, A., Chavanet, P., Piroth, L., Buisson, M., Mahy, S., Martins, C., Salmon-Rousseau, A., Gohier, S., Piper, C., Börgermann, J., Guckel, D., Horstkotte, D., Brockmeier, B., Winkelmann, E., Hagendorff, A., Grey, D., Nickenig, G., Schueler, R., Öztürk, C., Stöhr, E., Hamm, C., Walther, T., Brandt, R., Frühauf, A. C., Hartung, C. T., Hellner, C., Wild, C., Becker, M., Hamada, S., Kaestner, W., Stangl, K., Knebel, F., Baldenhofer, G., Brecht, A., Dreger, H., Isner, C., Pfafflin, F., Stegemann, M., Zahn, R., Fraiture, B., Kilkowski, C., Karcher, A. K., Klinger, S., Tolksdorf, H., Tousoulis, D., Aggeli, C., Sarri, G., Sideris, S., Venieri, E., Athanassopoulos, G., Tsiapras, D., Armenis, I., Koutsiari, A., Floros, G., Grassos, C., Dragasis, S., Rallidis, L., Varlamos, C., Michalis, L., Naka, K., Bechlioulis, A., Kotsia, A., Lakkas, L., Pappas, K., Papadopoulos, C., Kiokas, S., Lioni, A., Misailidou, S., Barbetseas, J., Bonou, M., Kapelios, C., Tomprou, I., Zerva, K., Manolis, A., Hamodraka, E., Athanasiou, D., Haralambidis, G., Poulimenos, L., Samaras, H., Nagy, A., Bartykowszki, A., Gara, E., Sengupta, S., Mungulmare, K., Kasliwal, R., Bansal, M., Bhan, A., Ranjan, S., Kyavar, M., Maleki, M., Bezanjani, F. Noohi, Sadeghpour, A., Alizadehasl, A., Boudagh, S., Ghavidel, A., Moradnejad, P., Pasha, H. R., Ghadrdoost, B., Gilon, D., Strahilevitz, J., Israel, S., Wanounou, M., d’Agostino, C., Colonna, P., de Michele, L., Fumarola, F., Stante, M., Marchionni, N., Scheggi, V., Alterini, B., del Pace, S., Stefano, P., Sparano, C., Badano, L. P., Muraru, D., Ruozi, N., Tenaglia, R., Limbruno, U., Cresti, A., Baratta, P., Solari, M., Giannattasio, C., Moreo, A., de Chiara, B., Montero, B. Lopez, Musca, F., Orcese, C. A., Panzeri, F., Russo, C. F., Spano, F., Alfieri, O., de Bonis, M., Agricola, E., Busnardo, E., Carletti, S., Castiglioni, B., Chiappetta, S., del Forno, B., Ferrara, D., Guffanti, M., Iaci, G., Lapenna, E., Nisi, T., Oltolini, C., Pajoro, U., Pasciuta, R., Ripa, M., Scarpellini, P., Din, C. Tassan, Meneghin, R., Schiavi, D., Piscione, F., Citro, R., Benvenga, R. M., Greco, L., Prota, C., Radano, I., Soriente, L., Bellino, M., di Vece, D., Santini, F., Salsano, A., Olivieri, G. 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C., Pierard L., Srdanovic I., Yamada H., et al., Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiology Dept, CHU Limoges, INSERM 1094, University Hospital Dupuytren, 87042, Limoges, Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, European Infective Endocarditis Registry (Euro-Endo), Abbott Vascular, AstraZeneca, ResMed, Sanofi, Servier, Vifor Pharma, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Pfizer, Daiichi Sankyo Europe, Eli Lilly and Company, Gedeon Richter, and Novartis Pharma
- Subjects
Microbiology (medical) ,Prognosi ,Immunology ,Infective endocarditi ,Life Sciences (LIFE) ,INTERNATIONAL COLLABORATION ,PROFILE ,AGE ,Elderly ,Propensity analysis ,Yaşam Bilimleri ,Health Sciences ,RISK ,İmmünoloji ,General Immunology and Microbiology ,Infective endocarditis ,Prognosis ,Surgery ,Temel Bilimler ,Life Sciences ,General Medicine ,INFECTIOUS DISEASES ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,BULAŞICI HASTALIKLAR ,Yaşam Bilimleri (LIFE) ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Propensity analysi ,Natural Sciences - Abstract
Purpose: High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods: Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results: As compared to < 80yo patients, ≥ 80yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p < 0.001), of surgery performed (37.0% vs. 75.5%, p < 0.001), and a higher in-hospital (25.9% vs. 15.8%, p < 0.001) and 1-year mortality (41.3% vs. 22.2%, p < 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43–3.66]). By propensity analysis, 304 ≥ 80yo were matched to 608 < 80yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p < 0.0001) in ≥ 80yo. Overall mortality remained higher in ≥ 80yo (in-hospital: HR 1.50[1.06–2.13], p = 0.0210; 1-yr: HR 1.58[1.21–2.05], p = 0.0006), but was not different from that of < 80yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion: Although mortality rates are consistently higher in ≥ 80yo patients than in < 80yo patients in the general population, mortality of surgery in ≥ 80yo is similar to < 80yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in ≥ 80yo patients.
- Published
- 2022
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14. Correction to: Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry (Infection, (2022), 50, 5, (1191-1202), 10.1007/s15010-022-01792-0)
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Pazdernik, Michal, Iung, Bernard, Mutlu, Bulent, Alla, François, Riezebos, Robert, Kong, William, Nunes, Maria Carmo Pereira, Pierard, Luc, Srdanovic, Ilija, Yamada, Hirotsugu, de Martino, Andrea, Miglioranza, Marcelo Haertel, Magne, Julien, Piper, Cornelia, Laroche, C. cile, Maggioni, Aldo P., Lancellotti, Patrizio, Habib, Gilbert, Selton-Suty, Christine, Ronderos, R., Avegliano, G., Oses, P. Fernandez, Filipini, E., Granada, I., Iribarren, A., Mahia, M., Nacinovich, F., Ressi, S., Obregon, R., Bangher, M., Dho, J., Cartasegna, L., Plastino, M. L., Novas, V., Shigel, C., Reyes, G., de Santos, M., Gastaldello, N., Fernandez, M. Granillo, Potito, M., Streitenberger, G., Velazco, P., Casabé, J. H., Cortes, C., Guevara, E., Salmo, F., Seijo, M., Weidinger, F., Heger, M., Brooks, R., Stöllberger, C., Ho, C. Y., Perschy, L., Puskas, L., Goliasch, G., Binder, C., Rosenhek, R., Schneider, M., Winter, M. 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P., Dworakowski, R., Fife, A., Breeze, J., Browne-Morgan, M., Gunning, M., Streather, S., Asch, F., Zemedkun, M., Alyavi, B., Uzokov, J., Graduate School, ACS - Heart failure & arrhythmias, Cardiology, Radiotherapy, CCA - Imaging and biomarkers, and ACS - Atherosclerosis & ischemic syndromes
- Abstract
In this article the “EURO-ENDO Investigators group” member U. Y. Sinan was incorrectly written as U.S. Yasar. The original article has been corrected.
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- 2022
15. A heuristic algorithm for optimal cost design of gravity-fed water distribution networks. a real case study
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Gabriel F. Calvo, David G. Aragones, and Álvaro Galán
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Class (computer programming) ,Mathematical optimization ,Optimization problem ,Heuristic (computer science) ,Total cost ,Computer science ,Applied Mathematics ,02 engineering and technology ,Network theory ,Network topology ,01 natural sciences ,Overcurrent ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Modeling and Simulation ,0103 physical sciences ,010301 acoustics ,Metaheuristic - Abstract
In this work, we put forward a new algorithm for minimizing the total cost of gravity-fed water distribution networks (WDN) by optimally choosing pipe diameters. Our approach is based on network theory and heuristic procedures and aims at overcoming a number of limitations found in the current scientific literature. WDN optimization problems belong to those that are discrete, non-linear and non-convex, making the use of standard optimization algorithms inefficient. Furthermore, resorting to metaheuristic search techniques to test many different solutions has an exceedingly expensive computational cost, due to the inherent complexity of the problem. Here we present an efficient heuristic algorithm that circumvents these limitations, exploiting detailed aspects, such as the specific network topology. In order to check the capability of the algorithm in a realistic setting, we have developed and analyzed a mathematical model of a water distribution network in a Spanish municipality, considerably larger than those addressed in previous works. Our numerical results indicate significant potential construction savings over current design practices, which justifies the interest of our approach in addressing this class of optimization problems.
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- 2021
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16. Cinemática de tronco durante la marcha en pacientes con ictus: revisión sistemática
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W. Mella, J. P. González, Marcela Cárcamo, M. F. Calvo, Felipe H. Palma, and Oscar Valencia
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030506 rehabilitation ,03 medical and health sciences ,0302 clinical medicine ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,0305 other medical science ,030217 neurology & neurosurgery - Abstract
Resumen El tronco y la pelvis se afectan como consecuencia de un ictus, lo que predispone a caidas y dependencia. El objetivo de esta revision fue describir la cinematica lineal y angular de tronco y pelvis durante la marcha en pacientes con secuela de accidente cerebrovascular. Se incluyeron estudios publicados hasta junio de 2018 que hubieran utilizado un sistema de captura de movimiento 2-3D durante la marcha. La busqueda fue en Cochrane, Medline, PEDRo, Lilacs, Scielo, EBSCO, ClinicalKey y Elsevier. Se seleccionaron 12 articulos. La cinematica lineal muestra mayores desplazamientos laterales y aceleracion en todos los ejes. La cinematica angular en fase de balanceo del segmento paretico presenta la pelvis en rotacion posterior, elevada y con menor velocidad, y tronco en flexion anterior, inclinacion lateral y rotacion ipsilaterales. Los estudios tienen alta variabilidad, lo que imposibilita establecer una medida de efecto comun. Sin embargo, los resultados permiten describir el comportamiento del tronco y de la pelvis.
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- 2021
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17. Custard apple crop residues combustion: an overall study of their energy behaviour under different fertilisation conditions
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Alba Prado-Guerra, Luis F. Calvo, Sergio Reyes, Francisco Lima, and Sergio Paniagua
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Renewable Energy, Sustainability and the Environment - Published
- 2022
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18. Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure:a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry
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Bohbot, Yohann, Habib, Gilbert, Laroche, Cécile, Stöhr, Elisabeth, Chirouze, Catherine, Hernandez-Meneses, Marta, Melissopoulou, Maria, Mutlu, Bülent, Scheggi, Valentina, Branco, Luísa, Olmos, Carmen, Reyes, Graciela, Pazdernik, Michal, Iung, Bernard, Sow, Rouguiatou, Mirocevic, Maja, Lancellotti, Patrizio, Tribouilloy, Christophe, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, P Fernandez Oses, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, M De Santos, Gastaldello, N, M Granillo Fernandez, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, C-Y, Ho, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, M-P, Winter, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, 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Male ,Congestive heart failure ,Survival ,SURGERY ,IMPACT ,Hospital mortality ,Infective endocarditi ,Sağlık Bilimleri ,Cardiovascular ,Clinical Medicine (MED) ,Endocarditis, Bacterial/complications ,PROGNOSTIC-FACTORS ,KALP VE KALP DAMAR SİSTEMLERİ ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Early surgery ,Klinik Tıp (MED) ,Prospective Studies ,Registries ,PREDICTORS ,ComputingMilieux_MISCELLANEOUS ,Outcome ,RISK ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Klinik Tıp ,DEATH ,Middle Aged ,Tıp ,Heart Failure/complications ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Medicine ,Female ,EURO-ENDO ,Cardiology and Cardiovascular Medicine ,Kardiyoloji ,Kardiyoloji ve Kardiyovasküler Tıp ,NATIVE VALVE ENDOCARDITIS ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Endocarditis/complications ,Health Sciences ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Retrospective Studies ,Internal Medicine Sciences ,MORTALITY ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Dahili Tıp Bilimleri ,ADULTS ,Infective endocarditis ,CLINICAL MEDICINE ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,CARDIAC & CARDIOVASCULAR SYSTEMS - Abstract
International audience; AIMS: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry. METHODS AND RESULTS: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n~=~698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10\,mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p\,≤q\,0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHF remained strongly associated with 30-day (odds ratio[OR] 2.37, 95% confidence interval [CI] [1.73-3.24; p\,10\,mm, severe valvular regurgitation and/or new prosthetic dehiscence, perivalvular complication, and prosthetic IE (OR 0.22, 95% CI 0.12-0.38; p\
- Published
- 2022
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19. C30 24–HOUR PULMONARY ARTERY ELASTANCE IS THE STRONGEST HEMODYNAMIC PREDICTOR OF IN–HOSPITAL MORTALITY IN ACUTE DECOMPENSATED HEART FAILURE–RELATED CARDIOGENIC SHOCK
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L Baldetti, C Den Uil, G Fiore, G Gallone, D Romagnolo, T De Ferrari, B Peveri, L Cianfanelli, F Calvo, M Gramegna, V Pazzanese, S Sacchi, A Frias, S Ajello, and A Scandroglio
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Cardiology and Cardiovascular Medicine - Abstract
Aim The initial bundle of cares strongly affects hemodynamics in acute decompensated heart failure cardiogenic shock (ADHF–CS). We sought to characterize whether 24–hour hemodynamic profiling provides superior prognostic information as compared to admission assessment, and which hemodynamic parameters best predict in–hospital death. Methods and results We included 99 patients (62±14 years, 24.2% females) with ADHF–CS and available admission and 24–hour invasive hemodynamic assessment from two academic institutions. Overall, in–hospital mortality was 28.3%. In the admission multivariable model, age (OR=1.08; 95%CI 1.03–1.13; padj=0.002) and CPIRAP (OR=0.62; 95%CI 0.39–0.90; padj=0.022) were significantly associated with in–hospital death. Among several 24–hour hemodynamic univariate predictors of in–hospital death, pulmonary artery elastance (PaE) was the strongest (AUC 0.73; 95%CI 0.66–0.86). At 24–hours, PaE (OR=5.86; 95%CI 1.87–18.50; padj=0.003), PAPi (OR=0.75; 95%CI 0.55–0.92; padj=0.023) and age (OR=1.08; 95%CI 0.1.03–0.1.14; padj=0.005) were independently associated with in–hospital death. This 24–hour model outperformed admission model (AUC 0.85 [0.76–0.93] vs AUC 0.77 [0.67–0.88]; Figure 1). Patients were then grouped according to the optimal cutpoints of PaE 1.11 mmHg/mL and PAPi 2.12. Patients with high 24–hour PaE exhibited the highest in–hospital mortality at either low and high PAPi. The “high PAPi–low PaE” group had best parameter of (bi)ventricular function and lowest right and left filling pressures; the “low PAPi–low PaE” group exhibited parameters of poor RV function and high RAP (prevalent RV dysfunction); the “high PAPi–high PaE” group had signs of LV dysfunction coupled with parameters of relatively preserved RV function (compensated RV afterload mismatch); finally, the “low PAPi–high PaE” group exhibited worse parameters of LV and RV functions, coupled with high degree of pulmonary circulation overload and high biventricular filling pressures (decompensated RV afterload mismatch). We observed a different mortality in the cohorts identified by this classification (13.5 vs 25.0 vs 50.0 vs 43.8%; p=0.016, Figure 2). Conclusion PaE was the most powerful 24–hour hemodynamic predictor of in–hospital death in ADHF–CS. This index, coupled with PAPi, may identify patients with RV afterload mismatch and was independently associated with hospital mortality event after adjustment for multiple clinically relevant variables.
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- 2023
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20. Sequentially exporting products across countries
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Facundo Albornoz, Héctor F. Calvo Pardo, Gregory Corcos, and Emanuel Ornelas
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Economics and Econometrics ,Finance - Published
- 2023
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21. Small ponds support high terrestrial bird species richness in a Mediterranean semiarid region
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Antonio Zamora-López, Francisco J. Oliva-Paterna, José F. Calvo, María V. Jiménez-Franco, and José M. Zamora-Marín
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0106 biological sciences ,Mediterranean climate ,Ecology ,010604 marine biology & hydrobiology ,fungi ,Biodiversity ,Endangered species ,Aquatic Science ,010603 evolutionary biology ,01 natural sciences ,Freshwater ecosystem ,Ecosystem services ,Geography ,Taxon ,Habitat ,parasitic diseases ,Species richness - Abstract
Ponds are among the world’s most endangered freshwater ecosystems. A comprehensive knowledge of pond biodiversity is urgently required to inform effective pond management and conservation actions. Most studies about pond biodiversity focus on aquatic taxa, while the terrestrial biodiversity, especially of birds, has been little studied. Moreover, the few studies existing on pond biodiversity do not account for different detection rates of species, thus yielding biased results. Here, we apply a hierarchical Bayesian modelling technique to data obtained from visual censuses to estimate bird species richness associated with small ponds in a semiarid region, considering the imperfect detection of species. The model incorporates specific responses to site characteristics (pond typology), landscape (environmental heterogeneity) and at regional scale (mean annual precipitation). The studied ponds were used by two thirds of the terrestrial breeding bird community of the study region. Our modelling approach increased by an average of 7.5 species the observed site-specific richness. Drinking troughs supported a greater richness than other pond types. Environmental heterogeneity was positively related with species richness, whereas no clear relation was observed between richness and precipitation. In addition to ecosystem services provided by ponds to human welfare, our results suggest these small isolated habitats may act as key landscape elements for terrestrial birds in semiarid regions.
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- 2021
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22. Comparing detectability patterns of bird species using multi-method occupancy modelling
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José F. Calvo, Antonio Zamora-López, José M. Zamora-Marín, and Francisco J. Oliva-Paterna
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0106 biological sciences ,Conservation of Natural Resources ,Occupancy ,Behavioural ecology ,Science ,Species distribution ,Biodiversity ,010603 evolutionary biology ,01 natural sciences ,Article ,Birds ,Statistics ,Animals ,Community ecology ,Netting ,Combined method ,Ecosystem ,Ecological modelling ,Multidisciplinary ,010604 marine biology & hydrobiology ,Sampling (statistics) ,Arid ,Spain ,Environmental science ,Medicine ,Multi method - Abstract
A robust knowledge of biodiversity distribution is essential for designing and developing effective conservation actions. The choice of a suitable sampling method is key to obtaining sufficiently accurate information of species distribution and consequently to improve biodiversity conservation. This study applies multi-method occupancy models to 36 common bird species associated with small ponds in the province of Murcia (south-eastern Spain), one of the most arid regions of Europe, in order to compare their effectiveness for detecting different bird species: direct observation, combined observation and video monitoring and mist netting captures. The results showed that the combined method and direct observation were similar and most effective than mist netting for detecting species occupancy, although detection rates ranged widely among bird groups, while some large species were poorly detected by all the methods used. Average detectability did not increase during the breeding period. The chosen approach is particularly applicable to both single- and multi-species bird monitoring programmes. However, we recommend evaluating the cost-effectiveness of all the available methods in order to reduce costs and improve the success of sampling designs.
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- 2021
23. Stochastic Fluctuations Drive Non-genetic Evolution of Proliferation in Clonal Cancer Cell Populations
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Carmen Ortega-Sabater, Gabriel F. Calvo, Jelena Dinić, Ana Podolski-Renic, Milica Pesic, and Víctor M. Pérez-García
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Lung Neoplasms ,Tumour heterogeneity ,General Mathematics ,Immunology ,Phenome ,Biology ,Models, Biological ,General Biochemistry, Genetics and Molecular Biology ,Carcinoma, Non-Small-Cell Lung ,Genotype ,Humans ,Evolutionary dynamics ,Ecosystem ,General Environmental Science ,Cell Proliferation ,Pharmacology ,Phenotypic plasticity ,Stochastic Processes ,General Neuroscience ,Mathematical Concepts ,Phenotype ,Biological Evolution ,Fixation (population genetics) ,Computational Theory and Mathematics ,Evolutionary biology ,Proteome ,General Agricultural and Biological Sciences - Abstract
Evolutionary dynamics allows us to understand many changes happening in a broad variety of biological systems, ranging from individuals to complete ecosystems. It is also behind a number of remarkable organizational changes that happen during the natural history of cancers. These reflect tumour heterogeneity, which is present at all cellular levels, including the genome, proteome and phenome, shaping its development and interrelation with its environment. An intriguing observation in different cohorts of oncological patients is that tumours exhibit an increased proliferation as the disease progresses, while the timescales involved are apparently too short for the fixation of sufficient driver mutations to promote an explosive growth. Here we discuss how phenotypic plasticity, emerging from a single genotype, may play a key role and provide a ground for a continuous acceleration of the proliferation rate of clonal populations with time. We address this question by combining the analysis of real time growth of non-small-cell lung carcinoma cells (line NCI-H460) together with stochastic and deterministic mathematical models that capture proliferation trait heterogeneity in clonal populations to elucidate the contribution of phenotypic transitions on tumour growth dynamics.
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- 2022
24. Bedside intra-aortic balloon pump implant in cardiac intensive care unit
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L Baldetti, A Boccellino, G Barone, G Gallone, A Venuti, M Gramegna, F Calvo, V Pazzanese, S Sacchi, and AM Cappelletti
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General Medicine ,Cardiology and Cardiovascular Medicine ,Critical Care and Intensive Care Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Background Intra-aortic balloon pumping (IABP) support has been progressively reappraised, especially for the acute decompensated heart failure (ADHF) cardiogenic shock (CS) scenario(1). IABP features an easy implantation technique and can rapidly be deployed bedside. This avoids the need of patient transfer to the catheterization laboratory (CathLab) and the inherent risk of destabilization and makes it an attractive approach in case of unstable hemodynamics. However, despite decades of IABP utilization, no data is available on the safety and feasibility of the IABP bedside implant. Aim Aim of this study was to assess the safety and feasibility of bedside IABP implant and to characterize the phenotype of patients who receive this support. Methods We retrospectively reviewed all consecutive patients who received bedside IABP in the last 12 months. For comparison purposes we also selected all consecutive patients who underwent IABP implant in the CathLab in the same timespan. Major vascular complication was defined as thoracic aortic dissection, access-related vascular injury leading to either death, unplanned percutaneous/surgical intervention, need for ≥4 blood unit transfusions, amputation for distal embolization, or irreversible end-organ damage. All analyses were performed with R. Results A total of 77 patients were included: 22 (28.6%) received bedside, and 55 (71.4%) CathLab IABP implant. A total of 62 (81.6%) patients were male, age was 73 (64-79) years, and invasive mechanical ventilation was required in 54 (70.1%): no differences were observed between groups. Bedside IABP implant was guided by trans-esophageal echocardiography in 10 (45.5%) and trans-thoracic echocardiography in 12 (54.5%) patients. Patients in the bedside IABP cohort had more often pre-existing heart failure (HF, 72.7 vs 32.7%; p=0.001), presented with ADHF (45.5 vs 12.7%; p=0.002) and in overt CS (77.3 vs 34.5%; p Conclusion In this single-center experience, bedside IABP implant appeared safe and feasible. No difference was observed in terms of in-hospital mortality or major vascular complications between the bedside and CathLab groups, despite worse clinical conditions in the bedside IABP group. This strategy was often employed in critically-ill patients with ADHF with CS, were IABP use is increasing.
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- 2022
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25. Mitochondria transfer from tumor-activated stromal cells (TASC) to primary Glioblastoma cells
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Fanny Geraldo, Víctor M. Pérez-García, Gabriel F. Calvo, Claire Pecqueur, Juan Belmonte-Beitia, Arturo Álvarez-Arenas, Lisa Oliver, François M. Vallette, Céline Salaud, Catherine Gratas, Delphine Garnier, Apoptosis and Tumor Progression (CRCINA-ÉQUIPE 9), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), University of Castilla-La Mancha (UCLM), Endothelium Radiobiology and Targeting (CRCINA-ÉQUIPE 14), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM), and Bernardo, Elizabeth
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0301 basic medicine ,Stromal cell ,medicine.medical_treatment ,Population ,Mesenchymal stromal cells ,Biophysics ,Brain tumor ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Mitochondrion ,Biochemistry ,Cell Line ,Extracellular Vesicles ,03 medical and health sciences ,0302 clinical medicine ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Tumor Cells, Cultured ,Tumor Microenvironment ,Organoid ,medicine ,Humans ,education ,Molecular Biology ,Cell Proliferation ,education.field_of_study ,Tumor microenvironment ,Chemotherapy ,Primary GBM cultures ,Brain Neoplasms ,Chemistry ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,Cell Biology ,medicine.disease ,Coculture Techniques ,Mitochondria ,3. Good health ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Glioblastoma ,Tunneling nanotubes - Abstract
International audience; The tumor microenvironment (TME) controls many aspects of cancer development but little is known about its effect in Glioblastoma (GBM), the main brain tumor in adults. Tumor-activated stromal cell (TASC) population, a component of TME in GBM, was induced in vitro by incubation of MSCs with culture media conditioned by primary cultures of GBM under 3D/organoid conditions. We observed mito-chondrial transfer by Tunneling Nanotubes (TNT), extracellular vesicles (EV) and cannibalism from the TASC to GBM and analyzed its effect on both proliferation and survival. We created primary cultures of GBM or TASC in which we have eliminated mitochondrial DNA [Rho 0 (r 0) cells]. We found that TASC, as described in other cancers, increased GBM proliferation and resistance to standard treatments (radio-therapy and chemotherapy). We analyzed the incorporation of purified mitochondria by r 0 and r þ cells and a derived mathematical model taught us that r þ cells incorporate more rapidly pure mitochondria than r 0 cells.
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- 2020
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26. Universal scaling laws rule explosive growth in human cancers
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Ángel Acosta Rojas, Esther Hernández-San Miguel, María Pérez-Cano, Gabriel F. Calvo, Lucía Zhu, Ana María García Vicente, Juan Belmonte-Beitia, Juan J. Jiménez, David Albillo, Philippe Schucht, Víctor M. Pérez-García, Pedro García-Gómez, Antonio Francisco Honguero Martínez, François M. Vallette, Manuel Valiente, Jesús J. Bosque, Álvaro Martínez, Julián Pérez-Beteta, David Molina-García, Youness Azimzade, Odelaisy León-Triana, Michael Murek, Pilar Sánchez-Gómez, Ana Ortiz de Mendivil, Rafael Hortigüela, Germán Andrés Jiménez Londoño, Estanislao Arana, Universidad de Castilla-La Mancha (UCLM), Spanish National Cancer Research Center (CNIO), Institute of Health Carlos III, University of Tehran, Sanchinarro University Hospita [HM Hospitales, Madrid], Apoptosis and Tumor Progression (CRCINA-ÉQUIPE 9), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Bern University Hospital [Berne] (Inselspital), MD Anderson Cancer Center [Madrid, Spain], Hospital General Universitario de Albacete, Hospital General Universitario de Ciudad Real [Ciudad Real, Spain], Fundación Instituto Valenciano de Oncología [Valencia, Spain], James S. McDonnell Foundation 21st Century Science Initiative in Mathematical and Complex Systems Approaches for Brain Cancer, European Regional Development Fund (ERDF/FEDER), Junta de Comunidades de Castilla-La Mancha, Ministerio de Economia y Competividad (MINECO), Bristol-Myers Squibb, Beug Foundation's Prize for Metastasis Research 2017, Fundacion Ramon Areces, Worldwide Cancer Research, H2020-FETOPEN, Fundacio La Marato de TV3, Clinic and Laboratory Integration Program CRI Award 2018, AECC Coordinated Translational Groups 2017, LAB AECC 2019, La Caixa INPhINIT Fellowship, La Caixa-Severo Ochoa International PhD Program Fellowship, European Molecular Biology Organization Young Investigators programme, Bernardo, Elizabeth, Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM), and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
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Scaling law ,Explosive material ,Computer science ,General Physics and Astronomy ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,01 natural sciences ,Measure (mathematics) ,Article ,010305 fluids & plasmas ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,GENERAL-MODEL ,0103 physical sciences ,RATES ,Statistical physics ,Tissues and Organs (q-bio.TO) ,010306 general physics ,Set (psychology) ,Evolutionary dynamics ,Mathematical model ,TUMOR-GROWTH ,Quantitative Biology - Tissues and Organs ,Observable ,EVOLUTION ,PREDICTS ,3. Good health ,PET ,Oncología matemática ,FOS: Biological sciences ,SURVIVAL ,Biomedicina ,Value (mathematics) - Abstract
Most physical and other natural systems are complex entities composed of a large number of interacting individual elements. It is a surprising fact that they often obey the so-called scaling laws relating an observable quantity with a measure of the size of the system. Here we describe the discovery of universal superlinear metabolic scaling laws in human cancers. This dependence underpins increasing tumour aggressiveness, due to evolutionary dynamics, which leads to an explosive growth as the disease progresses. We validated this dynamic using longitudinal volumetric data of different histologies from large cohorts of cancer patients. To explain our observations we put forward increasingly-complex biologically-inspired mathematical models that captured the key processes governing tumor growth. Our models predicted that the emergence of superlinear allometric scaling laws is an inherently three-dimensional phenomenon. Moreover, the scaling laws thereby identified allowed us to define a set of metabolic metrics with prognostic value, thus providing added clinical utility to the base findings. This research has been supported by the James S. McDonnell Foundation 21st Century Science Initiative in Mathematical and Complex Systems Approaches for Brain Cancer (collaborative awards 220020560 and 220020450), Ministerio de Economia y Competitividad/FEDER, Spain (grant no. MTM2015-71200-R), Junta de Comunidades de Castilla-La Mancha (grant no. SBPLY/17/180501/000154). Research in the Brain Metastasis Group is supported by MINECO grant MINECO-Retos SAF2017-89643-R (M.V.), Bristol-Myers Squibb Melanoma Research Alliance Young Investigator Award 2017 (498103) (M.V.), Beug Foundation's Prize for Metastasis Research 2017 (M.V.), Fundacion Ramon Areces (CIVP19S8163) (M.V.), Worldwide Cancer Research (19-0177) (M.V.), H2020-FETOPEN (828972) (M.V.), Fundacio La Marato de tv3 (141), Clinic and Laboratory Integration Program CRI Award 2018 (54545) (M.V.), AECC Coordinated Translational Groups 2017 (GCTRA16015SEOA) (M.V.), LAB AECC 2019 (LABAE19002VALI) (M.V.), La Caixa INPhINIT Fellowship (LCF/BQ/IN17/11620028) (P.G.-G.), La Caixa-Severo Ochoa International PhD Program Fellowship (LCF/BQ/SO16/52270014) (L.Z.). M.V. is a member of the European Molecular Biology Organization Young Investigators programme (4053). We would like to acknowledge J. Cervera and J. C. Penalver from the IVO Foundation (Valencia, Spain). No
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- 2020
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27. Syphilitic Chancre of the Lip
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Davinia F Calvo, David S. Cassarino, and Angel Fernandez-Flores
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Male ,Sexually transmitted disease ,medicine.medical_specialty ,Dermatology ,Oral cavity ,Pathology and Forensic Medicine ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Syphilis Serodiagnosis ,0302 clinical medicine ,Syphilitic chancre ,medicine ,Humans ,Sex organ ,Treponema pallidum ,Treponema ,biology ,business.industry ,Lip Diseases ,General Medicine ,Middle Aged ,medicine.disease ,biology.organism_classification ,Chancre ,Immunohistochemistry ,stomatognathic diseases ,Syphilis ,medicine.symptom ,business ,Immunocompetence - Abstract
Syphilis is a sexually transmitted disease caused by Treponema pallidum. The primary stage of the disease (the chancre) mainly involves the genital areas. Extragenital areas are involved in 5%-14% of cases, many of which occur in the oral cavity. Among the extragenital locations, the lip is the most frequent; however, despite this, published cases of the chancre of the lip are few. We present a case of a chancre presenting on the lip of a nonimmunocompromised 55-year-old male patient with immunohistochemical confirmation.
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- 2020
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28. Evidence of non-random mating in a colour polymorphic raptor, the Booted Eagle
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Joan Mestre, José Enrique Martínez, Josep Bosch, María V. Jiménez-Franco, Claudi Baiges, and José F. Calvo
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0106 biological sciences ,genetic structures ,biology ,Secondary sex characteristic ,Offspring ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,010605 ornithology ,symbols.namesake ,Evolutionary biology ,Polymorphism (computer science) ,Sexual selection ,Mendelian inheritance ,symbols ,Mating ,Booted eagle ,Transmission ratio - Abstract
Sexual selection and non-random mating are considered, among others, determinant mechanisms for the maintenance of genetic colour polymorphism in some bird species. We analyse the mechanisms, which, in parallel with Mendelian inheritance, may be acting in the maintenance and evolution of the morph ratio in a two-morph raptor species, using observational data of successful breeding individuals and their offspring from long-term studies conducted in three Spanish populations. Our results showed that the dark offspring produced in breeding events involving mixed-morph adult pairs far exceeds the expected value under the Hardy–Weinberg equilibrium, especially in the case of pairs formed by a light male and a dark female. In addition, the low number of dark eaglets born from pairs formed by light individuals (indistinctly homozygous or heterozygous) indicates that the number of breeding events of heterozygous (both the male and female) light morph pairs, was much lower than expected. As the plausible existence of a transmission ratio distortion phenomenon in heterozygous light morph males does not, alone, explain the disproportionate number of dark eaglets observed, our results suggest that one or two selective mating phenomena may be occurring in this polymorphic system. The first one could be a disassortative mating process whereby heterozygous light males preferentially mate with dark females, based on the imprint of the colour morph of their mother. The second phenomenon would only affect light morph individuals, which would preferentially mate with heterozygous individuals of the opposite sex, selected according to secondary sexual characteristics or behavioural traits that are unknown at the moment.
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- 2020
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29. Modelling the role of flux density and coating on nanoparticle internalization by tumor cells under centrifugation
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Gabriel F. Calvo, Angel Ayuso-Sacido, Juan Belmonte-Beitia, Belén Cortés-Llanos, and Gorka Salas
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Chemistry ,Applied Mathematics ,media_common.quotation_subject ,Nanoparticle ,Nanotechnology ,Tumor cells ,engineering.material ,Key features ,Coating ,Modeling and Simulation ,engineering ,Centrifugation ,Internalization ,media_common - Abstract
Nanoparticle (NP)-based applications are becoming increasingly important in the biomedical field. However, understanding the interactions of NPs with biofluids and cells is a major issue in order to develop novel approaches aimed at boosting their internalization and, therefore, their translation into the clinic. To this end, we put forward a transport mathematical model to describe the spatio-temporal dynamics of iron oxide NPs and their interaction with cells under moderate centrifugation. Our numerical simulations allowed us to quantify the relevance of the flux density as one of the unavoidable key features driving NPs interaction with the media as well as for cell internalization processes. These findings will help to increase the efficiency of cell labelling for biomedical applications.
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- 2020
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30. Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry
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Sengupta, Shantanu P, Prendergast, Bernard, Laroche, Cécile, Furnaz, Shumaila, Ronderos, Ricardo, Almaghraby, Abdallah, Asch, Federico M, Blechova, Kamila, Zaky, Hosam, Strahilevitz, Jacob, Dworakowski, Rafal, Miyasaka, Yoko, Sebag, Igal, Izumi, Chisato, Axler, Olivier, Jamiel, Abdulrahman, Philip, Mary, Campos Vieira, Marcelo Luiz, Lancellotti, Patrizio, Habib, Gilbert, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, P Fernandez Oses, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, M De Santos, Gastaldello, N, M Granillo Fernandez, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, C-Y, Ho, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, M-P, Winter, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, L Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, L Andrade, J, Staszko, K, R Dos Santos Monteiro, H Miglioranza, M, L Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, P Siciliano, A, F Villaca Filho, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, N Falcao, S, A Moises, V, Gouvea, A, J Mancuso, F, C Souza, A, Y Silva, C, João, G, S Abboud, C, R Bellio de Mattos Barretto, Ramos, A, Arnoni, R, E Assef, J, J Della Togna, D, D Le Bihan, Miglioli, L, P Romero Oliveira, A, R Tadeu Magro Kroll, Cortez, D, L Gelape, C, M D, C Peirira Nunes, C De Abreu Ferrari, T, Hay, K, V, Le, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, A Sebag, I, G Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, 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C Castillo, J, L Zamorano, J, L Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, M Monteagudo, J, E Navas Elorza, C Farinas Alvarez, M, J Aguero Balbin, Zarauza, J, F Gutierrez-Diez, J, Arminanzas, C, F Arnaiz de Las Revillas, A Arnaiz Garcia, M Cobo Belaustegui, M Fernandez Sampedro, M Gutierrez Cuadra, L Garcia Cuello, C Gonzalez Rico, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, M Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, M Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, A Bardaji Ruiz, E Sanz Girgas, Garcia-Pardo, G, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, Abid, L, Hammami, R, Kammoun, S, S Mourali, M, F Mghaieth Zghal, M Ben Hlima, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, S Yasar, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), 2011–21, Abbott Vascular, 2009–18, Amgen, 2016–19, Edwards, 2014–16, Gedeon Richter, 2009–12, Menarini Group, 2011–14, MSD, 2014–20, Novartis Pharma, 2014–16, ResMed Foundation, 2009–11, Sanofi, 2009–21, Servier, 2019–22, Vifor Pharma, 2014–21, AstraZeneca, 2009–18, Bayer AG, 2009–19, Boehringer Ingelheim, 2009–12, Boston Scientific, Bristol Myers Squibb, 2011–19, Pfizer Alliance, 2011–20, Daiichi Sankyo Company, 2014–17, Eli Lilly and Company, Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, 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J, Pibarot, P, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, El-Gebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Bee-Harry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Go-Hier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nick-Enig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Bar-Betseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Morad-Nejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Mar-Chionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alferi, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasci-Uta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shi-Tan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Pis-Copo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Gre-Jdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfle, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Waha-Dat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kamin-Ska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Ko-Tova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vi-Lacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Bianco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tar-Radellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-De-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Ham-Mami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, and Uzokov, J
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Socioeconomic ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Endocarditis ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Health Policy ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Socio-economic ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Endocarditi ,Cardiology and Cardiovascular Medicine ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology - Abstract
Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53–75) years; group 2, 57 (41–68) years; group 3, 33 (26–43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3–35); group 2, 19 (6–54); group 3, 31 (12–62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.
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31. Interstellar methanol: the challenge of reactivity under astrophysical conditions
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D., Comte, L., Lavy, T., Salbaing, P., Bertier, B., Farizon, M., Farizon, T.D., Märk, F., Calvo, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Image Perception Interaction (LS2N - équipe IPI), Laboratoire des Sciences du Numérique de Nantes (LS2N), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Nantes Université (Nantes Univ), Institut für Ionenphysik und Angewandte Physik - Institute for Ion Physics and Applied Physics [Innsbruck], Leopold Franzens Universität Innsbruck - University of Innsbruck, Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy ), and Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
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[PHYS.PHYS.PHYS-ATM-PH]Physics [physics]/Physics [physics]/Atomic and Molecular Clusters [physics.atm-clus] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2022
32. Machine Learning the Carbon Footprint of Bitcoin Mining
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Hector F. Calvo-Pardo, Tullio Mancini, and Jose Olmo
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dropout methods ,Bitcoin mining ,machine learning ,neural networks ,CO2 ,ddc:330 - Abstract
Building on an economic model of rational Bitcoin mining, we measured the carbon footprint of Bitcoin mining power consumption using feed-forward neural networks. We found associated carbon footprints of 2.77, 16.08 and 14.99 MtCO2e for 2017, 2018 and 2019 based on a novel bottom-up approach, which (i) conform with recent estimates, (ii) lie within the economic model bounds while (iii) delivering much narrower prediction intervals and yet (iv) raise alarming concerns, given recent evidence (e.g., from climate–weather integrated models). We demonstrate how machine learning methods can contribute to not-for-profit pressing societal issues, such as global warming, where data complexity and availability can be overcome.
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- 2022
33. PRIMO WatchDog: a set of Python scripts to automate the simulations of IMRT and VMAT plans with the PRIMO Monte Carlo software
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Hermida-López, Marcelino and J. F. Calvo-Ortega
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- 2022
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34. Functional activation of the periaqueductal gray matter during conditioned and unconditioned fear in guinea pigs confronted with the Boa constrictor constrictor snake
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B.B. de Paula, E.B. Vieira-Rasteli, F. Calvo, N.C. Coimbra, and C.R.A. Leite-Panissi
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Male ,Neurons ,Boa constrictor constrictor ,Physiology ,General Neuroscience ,Guinea Pigs ,Immunology ,Periaqueductal gray matter ,Biophysics ,Conditioned fear ,Ocean Engineering ,Fear ,Cell Biology ,General Medicine ,Prey vs snake paradigm ,Immunohistochemistry ,Biochemistry ,Boidae ,COBRAS ,nervous system ,Animals ,Periaqueductal Gray ,General Pharmacology, Toxicology and Pharmaceutics ,Unconditioned fear - Abstract
The periaqueductal gray matter (PAG) is an essential structure involved in the elaboration of defensive responses, such as when facing predators and conspecific aggressors. Using a prey vs predator paradigm, we aimed to evaluate the PAG activation pattern evoked by unconditioned and conditioned fear situations. Adult male guinea pigs were confronted either by a Boa constrictor constrictor wild snake or by the aversive experimental context. After the behavioral test, the rodents were euthanized and the brain prepared for immunohistochemistry for Fos protein identification in different PAG columns. Although Fos-protein-labeled neurons were found in different PAG columns after both unconditioned and conditioned fear situations at the caudal level of the PAG, we found greater activation of the lateral column compared to the ventrolateral and dorsomedial columns after predator exposure. Moreover, the lateral column of the PAG showed higher Fos-labeled cells at the caudal level compared to the same area at the rostral level. The present results suggested that there are different activation patterns of PAG columns during unconditioned and conditioned fear in guinea pigs. It is possible to hypothesize that the recruitment of specific PAG columns depended on the nature of the threatening stimulus.
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- 2022
35. Behavioral immune landscapes of inflammation
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Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G. Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M. Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano del Valle, Sandra D. Castillo, Heidi C. E. Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E. Smithgall, Mauro Di Pilato, Thorsten R. Mempel, Pierre-Louis Tharaux, Santiago F. González, Angel Ayuso-Sacido, Lai Guan Ng, Gabriel F. Calvo, Iván González-Díaz, Fernando Díaz-de-María, Andrés Hidalgo, Ministerio de Ciencia e Innovación (España), Fundación La Caixa, Transatlantic Network of Excellence, Fondation Leducq, Unión Europea. Comisión Europea, Federation of European Biochemical Societies, European Molecular Biology Organization, Fundación ProCNIC, and Marie Curie
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Inflammation ,Proteomics ,Mice ,Multidisciplinary ,src-Family Kinases ,Neutrophils ,Proto-Oncogene Proteins ,Leukocytes ,Animals ,Endothelium ,Cell Shape ,Article - Abstract
Transcriptional and proteomic profiling of individual cells have revolutionized interpretation of biological phenomena by providing cellular landscapes of healthy and diseased tissues1,2. These approaches, however, do not describe dynamic scenarios in which cells continuously change their biochemical properties and downstream 'behavioural' outputs3-5. Here we used 4D live imaging to record tens to hundreds of morpho-kinetic parameters describing the dynamics of individual leukocytes at sites of active inflammation. By analysing more than 100,000 reconstructions of cell shapes and tracks over time, we obtained behavioural descriptors of individual cells and used these high-dimensional datasets to build behavioural landscapes. These landscapes recognized leukocyte identities in the inflamed skin and trachea, and uncovered a continuum of neutrophil states inside blood vessels, including a large, sessile state that was embraced by the underlying endothelium and associated with pathogenic inflammation. Behavioural screening in 24 mouse mutants identified the kinase Fgr as a driver of this pathogenic state, and interference with Fgr protected mice from inflammatory injury. Thus, behavioural landscapes report distinct properties of dynamic environments at high cellular resolution. This study was supported by RTI2018-095497-B-I00 from Ministerio de Ciencia e Innovación (MCIN), HR17_00527 from Fundación La Caixa, Transatlantic Network of Excellence (TNE-18CVD04) from the Leducq Foundation, and FET-OPEN (no. 861878) from the European Commission to A.H. M.P-S. is supported by a Federation of European Biochemical Societies and the EMBO ALTF (no. 1142-2020) long-term fellowships. J.S. is supported by a fellowship (PRE2019-089130) from MICINN and A.A.-C. is supported by fellowship CF/BQ/ DR19/11740022 from La Caixa Foundation. J.L.Y.L. was supported by A*STAR and a Juan de la Cierva JCI-2017-33136 Fellowship from MICINN. S.D.C. is a recipient of a Marie Sklodowska-Curie fellowship (749731). M.G. is supported by SAF2017-89116R-P from MCIN and HR18_00120 from la Fundación La Caixa. T.R.M. is supported by grant NIH AI163223, L.G.N. is supported by SIgN core funding from A*STAR, and G.F.C. is supported by MCIN/ AEI/10.13039/501100011033 (grant PID2019-110895RB-I00) and by Junta de Comunidades de Castilla-La Mancha (SBPLY/19/180501/000211). F.S.-C. is supported by MCIN (grant RTI2018- 102084-B-I00), O.S. is supported by the Leducq Foundation (TNE-18CVD04), F.D.-d.-M. is supported by MCIN (TEC2017-84395-P), and T.E.S. is supported by the National Cancer Institute, NIH grant CA233576. The CNIC is supported by the MCIN and the Pro-CNIC Foundation. Sí
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- 2022
36. Small-scale loops heated to transition region temperatures and their chromospheric signatures in the simulated solar atmosphere
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M. Skan, S. Danilovic, J. Leenaarts, F. Calvo, and M. Rempel
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Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,FOS: Physical sciences ,Astronomy and Astrophysics ,Solar and Stellar Astrophysics (astro-ph.SR) - Abstract
Recent observations revealed loop-like structures at very small scales visible in observables that sample transition region (TR) and coronal temperatures. Their formation remains unclear. We study an example of a bipolar system in realistic magnetohydrodynamic simulations and forward synthesis of spectral lines to investigate how these features occur. Computations are done using the MURaM code to generate model atmospheres. The synthetic H$\alpha$ and Si IV spectra are calculated at two angles ($\mu = 1$, $\mu = 0.66$) using the Multi3D code. Magnetic field lines are traced in the model and the evolution of the underlying field topology is examined. The synthetic H$\alpha$ dopplergrams reveal loops that evolve dramatically within a few minutes. The synthetic H$\alpha$ line profiles show observed asymmetries and doppler shifts in the line core. They, however, also show strong emission peaks in the line wings, even at the slated view. The synthetic Si IV emission features partly coincide with structures visible in H$\alpha$ dopplergrams and partly follow separate magnetic field threads. Some are even visible in the emission measure maps for the lg$(T /K)= [5.0, 5.5]$ temperature interval. The emission areas trace out the magnetic field lines rooted in opposite polarities in a bipolar region. We find that our results largely reproduce the observed features and their characteristics. A bipolar system with footpoints undergoing rapid movement and shuffling can produce many small-scale recurrent events heated to high temperatures. The morphology and evolution of the resulting observable features can vary depending on the viewing angle., Comment: Online material: https://dubshen.astro.su.se/~mosk1498/mov/fig16_4p.mp4
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- 2023
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37. Metabolic activity grows in human cancers pushed by phenotypic variability
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Jesús J. Bosque, Gabriel F. Calvo, David Molina-García, Julián Pérez-Beteta, Ana M. García Vicente, and Víctor M. Pérez-García
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Multidisciplinary - Published
- 2023
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38. A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma
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Lisa Oliver, Arturo Álvarez-Arenas, Céline Salaud, Juan Jiménez-Sanchez, Gabriel F. Calvo, Juan Belmonte-Beitia, Stephanie Blandin, Luciano Vidal, Victor Pérez, Dominique Heymann, and François M. Vallette
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Cancer Research ,Oncology ,3D co-cultures ,glioblastoma and mesenchymal stromal cells - Abstract
We have developed a 3D biosphere model using patient-derived cells (PDCs) from glioblastoma (GBM), the major form of primary brain tumors in adult, plus cancer-activated fibroblasts (CAFs), obtained by culturing mesenchymal stem cells with GBM conditioned media. The effect of MSC/CAFs on the proliferation, cell-cell interactions, and response to treatment of PDCs was evaluated. Proliferation in the presence of CAFs was statistically lower but the spheroids formed within the 3D-biosphere were larger. A treatment for 5 days with Temozolomide (TMZ) and irradiation, the standard therapy for GBM, had a marked effect on cell number in monocultures compared to co-cultures and influenced cancer stem cells composition, similar to that observed in GBM patients. Mathematical analyses of spheroids growth and morphology confirm the similarity with GBM patients. We, thus, provide a simple and reproducible method to obtain 3D cultures from patient-derived biopsies and co-cultures with MSC with a near 100% success. This method provides the basis for relevant in vitro functional models for a better comprehension of the role of tumor microenvironment and, for precision and/or personalized medicine, potentially to predict the response to treatments for each GBM patient.
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- 2023
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39. Nest-Building Effort is Not An Indicator of Male Quality In Bonelli’s Eagles, Aquila fasciata
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José Eduardo Martinez, José F. Calvo, Mario Álvarez, Iñigo Zuberogoitia, and Antoni Margalida
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Fishery ,Geography ,Nest ,media_common.quotation_subject ,Quality (business) ,media_common - Abstract
Raptors often use a variety of materials to build their nests (natural, such as branches, but also non-natural objects), presumably due to their insulating properties, their suitability to advertise occupancy of the nest, and to decrease pathogen and parasite loads. The amount of branches used in a nest is an indicator of parental quality and is often associated with increased breeding success. However, in raptors where both sexes collaborate in nest construction, it is unclear whether the effort expended by males (taking the amount of material carried to the nest as the potential predictor) could constitute an honest signal of parental quality to female conspecifics. We examined data on sex, type of material brought to the nest, breeding experience, timing, and nest-building investment prior to egg-laying from 32 identifiable Bonelli’s Eagles (Aquila fasciata) during the pre-laying period to investigate the relative contribution of the sexes to the amount of nest material gathered. We asked: (1) whether the nest-building investment of males could provide information to the females about their quality; and (2) whether the amount of material delivered to the nest by the male was related to breeding success. Despite the considerable investment of males in nest-building during the pre-laying period, our results indicate that this effort is not a consistent indicator of male quality to the female. Therefore, male nest-building behaviour and investment by Bonelli’s Eagles cannot be considered as an extended expression of their phenotype (an extended phenotypic signal). Nest-building behaviour by males in the early and late stages of nest-building, and the fact that males were not significantly more active builders, are discussed in the contexts of signaling nest occupancy to conspecifics and competitors, the decrease of parasite loads, and the strengthening of the pair-bond during the pre-laying period.
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- 2021
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40. Inference of mechanical properties and structural grades of bamboo by machine learning methods
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Juan Francisco Correal, Andrés F. Calvo, David Jorge Alexander Trujillo, and Juan S. Echeverry
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History ,Polymers and Plastics ,General Materials Science ,Building and Construction ,Business and International Management ,Industrial and Manufacturing Engineering ,Civil and Structural Engineering - Published
- 2022
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41. Effects of establishing a multidisciplinary pancreatic cancer clinic on time-to-treatment
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Raj Vaghjiani, Joy Sarkar, Zachary Stiles, Jennifer Pangelinan, Renuka V. Iyer, Benjamin F. Calvo, Moshim Kukar, Steven N. Hochwald, Nadia Karen Malik, Christos Fountzilas, Sylvia Vania Alarcon Velasco, and Leonid Cherkassky
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Cancer Research ,Oncology - Abstract
61 Background: Despite recent advances, pancreatic cancer remains an exceedingly morbid disease. This is often attributed to the lack of effective screening tools and the consequent late presentation of patients. The best prognosis is reserved for patients with resectable tumors thus highlighting the importance of swift evaluation and the initiation of treatment following a diagnosis. Multidisciplinary clinics allow for the expedient evaluation of patients by different subspecialties in the same day. Methods: A newly designed, multidisciplinary workflow (MDC-multidisciplinary care clinic) for patients recently diagnosed with pancreatic adenocarcinoma was established at a single, tertiary-care comprehensive cancer center in September of 2021. Patients presenting to MDC undergo same day consultation by surgical oncology, medical oncology, receive genetics counseling and testing, nutrition counseling, and additional support services as indicated. Patients from a prospectively maintained database were compared from before (n = 14) and after (n = 30) implementation of the new workflow. Average time to provider consultation, port placement, and initiation of neoadjuvant chemotherapy were compared using student’s t-test. Results: After a biopsy diagnosis of pancreatic adenocarcinoma, the time interval from initial surgical consultation to initial medical oncology consultation improved from 7d to 1d ( p=.003) with the implementation of MDC. Over 90% of patients were seen on the same day after the MDC was established, compared to just 7% before. There was no difference in the time from initial biopsy diagnosis to initial surgical consultation, biopsy to initial medical oncology consultation, biopsy to port placement, or biopsy to chemotherapy initiation. Conclusions: In this early experience with a new pancreatic cancer multidisciplinary clinic, patients experienced improvements in time to subspecialty evaluation by nearly 7 days. Additionally, prospective data on oncologic outcomes and patient quality-of-care metrics are ongoing; however, this quality improvement effort has already reduced patient burdens in accessing timely care. Our continued efforts focus on further improving care coordination along the entire patient cancer care trajectory.
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- 2022
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42. PO-1885 Analysis of Vascular and Circular Blood in Radiation Treatment Planning: Technological Options
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R.M. Meiriño, F. Calvo Manuel, J. Burguete, J. Serrano Andreu, J. Aristu, D. Azcona, M. Cambeiro, M. Vidorreta, J. Pascau, J.M. Delgado, and A. Alonso
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Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology - Published
- 2022
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43. Bat ecology and conservation in semi‐arid and arid landscapes: a global systematic review
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Gareth Jones, Ángeles Haz, Adison Altamirano, María V. Jiménez-Franco, José F. Calvo, and Fulgencio Lisón
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Geography ,Taxon ,Habitat ,Ecology ,Citizen science ,Conservation status ,Animal Science and Zoology ,Mammal ,Taxonomy (biology) ,Species richness ,Agricultural and Biological Sciences (miscellaneous) ,Arid ,Ecology, Evolution, Behavior and Systematics - Abstract
Semi‐arid and arid landscapes (dry‐lands) cover 41% of the Earth’s land surface over five continents. These areas are home to 55% of mammal species. Bats have the second highest species richness among mammals, and, although many species are adapted to arid conditions, they are particularly sensitive in these habitats and require conservation priority. Information on bats in arid and semi‐arid landscapes is scattered, patchy and focused on small‐scale studies; therefore, we undertook a systematic review using the PRISMA protocol to identify the current knowledge status, detect knowledge gaps and propose future research priorities. We analysed 346 published articles and evaluated 40 topics within five topic categories (taxa studied, methodologies used, biology, ecology and conservation). The most commonly studied topic categories were ecology and biology. However, we found a gap in the topic category conservation (including topics such as conservation status and roost conservation). Our network analysis of topics within the categories showed that most ecology papers were focused on distribution, species richness and habitat use. When we analysed keywords, we found that phylogeny, taxonomy and distribution demonstrated relatively high presence. Moreover, comparison of the percentage of studies conducted in dry‐lands and the percentage of land surface area covered by dry‐lands in the continents revealed that dry‐lands in Africa and Australia were especially under‐represented. Our review shows that knowledge of bats in semi‐arid and arid landscapes is biased towards new records of the distribution of species, as well as covering systematic/taxonomic and morphological aspects of bat biology. We suggest that research on conservation measures and guidelines to protect the bat species found in semi‐arid and arid landscapes should be prioritised, together with the sharing of knowledge with local practitioners and the development of citizen science programmes.
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- 2019
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44. Colour plumage polymorphism in the Booted Eagle: inheritance pattern and temporal stability of the morph frequencies
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José Eduardo Martinez, María V. Jiménez-Franco, José F. Calvo, Josep Bosch, C. Baiges, and J. Mestre
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symbols.namesake ,Inheritance (object-oriented programming) ,Evolutionary biology ,Plumage ,Polymorphism (computer science) ,Mendelian inheritance ,symbols ,Animal Science and Zoology ,Biology ,Booted eagle ,biology.organism_classification ,Ecology, Evolution, Behavior and Systematics - Published
- 2019
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45. Selection of iron precursor for preparation of 3D-solids of hydrophobic composites with γ-alumina and carbon nanostructured materials
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F. Calvo-Castañera, M. Soria-Sánchez, J. Álvarez-Rodríguez, and A. Maroto-Valiente
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Thermogravimetric analysis ,Materials science ,Renewable Energy, Sustainability and the Environment ,Carbon nanofiber ,020209 energy ,Strategy and Management ,05 social sciences ,Industrial catalysts ,chemistry.chemical_element ,02 engineering and technology ,Carbon nanotube ,equipment and supplies ,Chemical reaction ,Industrial and Manufacturing Engineering ,law.invention ,Contact angle ,chemistry ,Chemical engineering ,law ,050501 criminology ,0202 electrical engineering, electronic engineering, information engineering ,Hybrid material ,Carbon ,0505 law ,General Environmental Science - Abstract
An easy handling formulation of hybrid material, which could approach carbon nanomaterials application to industrial catalysts, of carbon nanofibers (CNF) and carbon nanotubes (CNT) over γ-alumina, C@alumina is described. The study discussed the selection of iron precursor to obtain mechanical stable hybrids by analysis of coverage effect of process preparation of seminal γ-alumina pellets, in order to evaluate the yield of carbon nanomaterials (CNFs/CNTs) coverage on the alumina pellets. Each C@alumina series were synthetized by catalytic vapor decomposition of acetylene at 1023 K, and were studied according to the nature of active phase, the iron precursor, by the light of characterization results obtained by thermogravimetric analysis and Scanning Electron Microscopy. Besides, ethanol reaction is employed as chemical reaction test for acid-base surface distribution analysis. Finally, the hydrophobic behavior of every precursor hybrid sample is discussed attending to contact angle. So, it was discussed from de nature of iron precursors of acetylacetonate, chloride, sulfate, cyanide, pentacarbonyl, phthalocyanine, 1,10-phenanthroline, ferrocene the surface structure of 3d-solids obtained, and it is correlated with the effects of iron precursor loading, pKa, and polar surface area (PSA) and metal-surface interaction. It was evidenced the effect of iron precursor selection over the C@alumina hybrid hydrophobic properties.
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- 2019
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46. Use of classical bird census transects as spatial replicates for hierarchical modeling of an avian community
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Francisco Robledano, María V. Jiménez-Franco, Marc Kéry, Mario León-Ortega, Miguel A. Esteve, and José F. Calvo
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0106 biological sciences ,Occupancy ,forest birds ,environmental covariates ,Bayesian probability ,Sample (statistics) ,010603 evolutionary biology ,01 natural sciences ,03 medical and health sciences ,Bayesian multispecies occupancy models ,Replication (statistics) ,Statistics ,Range (statistics) ,Transect ,Ecology, Evolution, Behavior and Systematics ,030304 developmental biology ,Nature and Landscape Conservation ,Mathematics ,Original Research ,0303 health sciences ,Ecology ,community size ,Sampling (statistics) ,cell size ,detectability ,historical data ,community models ,Species richness - Abstract
New monitoring programs are often designed with some form of temporal replication to deal with imperfect detection by means of occupancy models. However, classical bird census data from earlier times often lack temporal replication, precluding detection‐corrected inferences about occupancy. Historical data have a key role in many ecological studies intended to document range shifts, and so need to be made comparable with present‐day data by accounting for detection probability. We analyze a classical bird census conducted in the region of Murcia (SE Spain) in 1991 and 1992 and propose a solution to estimating detection probability for such historical data when used in a community occupancy model: the spatial replication of subplots nested within larger plots allows estimation of detection probability. In our study, the basic sample units were 1‐km transects, which were considered spatial replicates in two aggregation schemes. We fit two Bayesian multispecies occupancy models, one for each aggregation scheme, and evaluated the linear and quadratic effect of forest cover and temperature, and a linear effect of precipitation on species occupancy probabilities. Using spatial rather than temporal replicates allowed us to obtain individual species occupancy probabilities and species richness accounting for imperfect detection. Species‐specific occupancy and community size decreased with increasing annual mean temperature. Both aggregation schemes yielded estimates of occupancy and detectability that were highly correlated for each species, so in the design of future surveys ecological reasons and cost‐effective sampling designs should be considered to select the most suitable aggregation scheme. In conclusion, the use of spatial replication may often allow historical survey data to be applied formally hierarchical occupancy models and be compared with modern‐day data of the species community to analyze global change process.
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- 2019
47. Accuracy of the BD MAX™ vaginal panel in the diagnosis of infectious vaginitis
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Andrés Canut-Blasco, F. Calvo-Muro, I. Sáez de Castillo-Sedano, and Amaia Aguirre-Quiñonero
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Adult ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Adolescent ,030106 microbiology ,medicine.disease_cause ,Sensitivity and Specificity ,Gastroenterology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Vaginal disease ,Internal medicine ,Prevalence ,medicine ,Humans ,Gardnerella vaginalis ,030212 general & internal medicine ,Vaginitis ,Candidiasis, Vulvovaginal ,Aged ,Aged, 80 and over ,Vaginal Smears ,Trichomoniasis ,Clinical Laboratory Techniques ,business.industry ,Vaginosis, Bacterial ,General Medicine ,Middle Aged ,medicine.disease ,Infectious Diseases ,medicine.anatomical_structure ,Molecular Diagnostic Techniques ,Vagina ,Female ,Trichomonas vaginalis ,Reagent Kits, Diagnostic ,Bacterial vaginosis ,Trichomonas Vaginitis ,business ,Clue cell - Abstract
The aim of this study was to evaluate the BD MAX™ vaginal panel in the diagnosis of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoniasis by comparing it with conventional methods: (i) combination of Hay criteria and presence of clue cells with predominant growth of Gardnerella vaginalis, (ii) yeast culture, and (iii) combination of culture, wet mount microscopic examination, and an alternative molecular assay. One thousand vaginal samples of women ≥ 14 years were analyzed; 5% of the samples belonged to pregnant women. 19.3% were classified as BV, in 33.6% yeasts were recovered and in 1.5% TV was detected. For BV, sensitivity and specificity were of 89.8% and 96.5%, respectively; for VVC, sensitivity and specificity were of 97.4% and 96.8%, respectively, and for T. vaginalis, the sensitivity and specificity were of 100%. The BD MAX™ vaginal panel is highly sensitive and specific and simplifies the identification of infectious vaginitis.
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- 2019
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48. Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy
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Arturo Álvarez-Arenas, Juan Belmonte-Beitia, Gabriel F. Calvo, and Konstantin E. Starkov
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Discretization ,Generalization ,Quantitative Biology::Tissues and Organs ,Applied Mathematics ,010102 general mathematics ,Control variable ,Stability (learning theory) ,Optimal control ,01 natural sciences ,Metronomic Chemotherapy ,Singular control ,010101 applied mathematics ,Discrete Mathematics and Combinatorics ,Applied mathematics ,0101 mathematics ,Bang–bang control ,Mathematics - Abstract
In this paper, a non-trivial generalization of a mathematical model put forward in [ 35 ] to account for the development of resistance by tumors to chemotherapy is presented. A study of the existence and local stability of the solutions, as well as the ultimate dynamics of the model, is addressed. An analysis of different chemotherapeutical protocols using discretization and optimization methods is carried out. A number of objective functionals are considered and the necessary optimality conditions are provided. Since the control variable appears linearly in the associated problem, optimal controls are concatenations of bang-bang and singular arcs. A formula of the singular control in terms of state and adjoint variables is derived analytically. Bang-bang and singular controls from the numerical simulations are obtained where, in particular, singular controls illustrate the metronomic chemotherapy.
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- 2019
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49. Traditional small waterbodies as key landscape elements for farmland bird conservation in Mediterranean semiarid agroecosystems
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José M. Zamora-Marín, Antonio Zamora-López, David Sánchez-Fernández, José F. Calvo, and Francisco J. Oliva-Paterna
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Ecology ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation - Published
- 2022
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50. A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
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Juan Jiménez-Sánchez, Anton Popov, Víctor M. Pérez-García, Álvaro Martínez-Rubio, Juan Belmonte-Beitia, Gabriel F. Calvo, Julián Pérez-Beteta, Youness Azimzade, David Molina-García, Matemáticas, [Jiménez-Sánchez,J, Martínez-Rubio,Á, Popov,A, Pérez-Beteta,J, Molina-García,D, Belmonte-Beitia,J, Calvo,GF, Pérez-García,VM] Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain. [Martínez-Rubio,Á] Department of Mathematics, Universidad de Cádiz, Cádiz, Spain. [Martínez-Rubio,Á] Biomedical Research and Innovation Institute of Cádiz (INiBICA), Cádiz, Spain. [Azimzade,Y] Department of Physics, University of Tehran, Tehran, Iran., and This research has been supported by grants awarded to VMPG by James S. Mc. Donnell Foundation, United States of America, 21st Century Science Initiative in Mathematical and Complex Systems Approaches for Brain Cancer (collaborative award 220020560) and Junta de Comunidades de Castilla-La Mancha, Spain (grant number SBPLY/17/180501/000154). VMPG and GFC thank the funding from Ministerio de Ciencia e Innovación, Spain (grant number PID2019-110895RB-I00). This research has also been supported by a grant awarded to GFC and JBB by the Junta de Comunidades de Castilla-La Mancha,Spain (grant number SBPLY/19/180501/000211). AMR received support from Asociación Pablo Ugarte http://www.asociacionpablougarte.es). JJS received support from Universidad de Castilla-La Mancha (grant number 2020-PREDUCLM-15634)
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Heterogeneidad genética ,Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division [Medical Subject Headings] ,computer.software_genre ,Genetic heterogeneity ,0302 clinical medicine ,Cell Movement ,Biology (General) ,Mathematical model ,Brain Neoplasms ,Prognosis ,Evolutionary dynamic in tumors ,Oncología matemática ,Computational Theory and Mathematics ,Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology [Medical Subject Headings] ,Oncology ,030220 oncology & carcinogenesis ,Modeling and Simulation ,Disease Progression ,Cell Division ,Phenomena and Processes::Mathematical Concepts::Algorithms [Medical Subject Headings] ,Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings] ,Neoplasias encefálicas ,QH301-705.5 ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Stochastic Processes [Medical Subject Headings] ,Tumor heterogeneity ,03 medical and health sciences ,Spatio-Temporal Analysis ,Genetics ,Humans ,Computer Simulation ,Evolutionary dynamics ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma [Medical Subject Headings] ,Scale (chemistry) ,Evolución de tumores ,Biology and Life Sciences ,Computational Biology ,Information Science::Information Science::Computing Methodologies::Computer Simulation [Medical Subject Headings] ,medicine.disease ,Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death [Medical Subject Headings] ,030104 developmental biology ,Brain neoplasms ,ComputingMethodologies_PATTERNRECOGNITION ,Tumor progression ,Mutation ,Key (cryptography) ,Glioblastoma ,Software ,Developmental Biology ,0301 basic medicine ,Simulador mesoscópico ,Computer science ,Cancer Treatment ,Mecoscopic simulator ,Lung and Intrathoracic Tumors ,Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement [Medical Subject Headings] ,Computational biology ,Neoplasms ,Breast Tumors ,Medicine and Health Sciences ,Medical imaging data ,Mesoscopic physics ,Ecology ,Cell Death ,Simulation and Modeling ,Epitome ,Computer simulation ,Diseases::Neoplasms [Medical Subject Headings] ,Detección de tumores ,Neoplasias ,Simulación por ordenador ,División celular ,Cell Motility ,Biología computacional ,Algorithms ,Research Article ,Cell division ,Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings] ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Cell Migration ,Machine learning ,Research and Analysis Methods ,Models, Biological ,Cellular and Molecular Neuroscience ,Malignant Tumors ,Breast Cancer ,medicine ,Stochastic Processes ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [Medical Subject Headings] ,business.industry ,Cancers and Neoplasms ,Cell Biology ,Tumores ,Modelos matemáticos ,Head and Neck Cancers ,Artificial intelligence ,business ,computer - Abstract
Increasingly complex in silico modeling approaches offer a way to simultaneously access cancerous processes at different spatio-temporal scales. High-level models, such as those based on partial differential equations, are computationally affordable and allow large tumor sizes and long temporal windows to be studied, but miss the discrete nature of many key underlying cellular processes. Individual-based approaches provide a much more detailed description of tumors, but have difficulties when trying to handle full-sized real cancers. Thus, there exists a trade-off between the integration of macroscopic and microscopic information, now widely available, and the ability to attain clinical tumor sizes. In this paper we put forward a stochastic mesoscopic simulation framework that incorporates key cellular processes during tumor progression while keeping computational costs to a minimum. Our framework captures a physical scale that allows both the incorporation of microscopic information, tracking the spatio-temporal emergence of tumor heterogeneity and the underlying evolutionary dynamics, and the reconstruction of clinically sized tumors from high-resolution medical imaging data, with the additional benefit of low computational cost. We illustrate the functionality of our modeling approach for the case of glioblastoma, a paradigm of tumor heterogeneity that remains extremely challenging in the clinical setting., Los enfoques de modelado in silico cada vez más complejos ofrecen una forma de acceder simultáneamente a procesos cancerosos en diferentes escalas espacio-temporales. Los modelos de alto nivel, como los que se basan en ecuaciones diferenciales parciales, son computacionalmente asequibles y permiten estudiar tumores de gran tamaño y ventanas temporales largas, pero pasan por alto la naturaleza discreta de muchos procesos celulares subyacentes clave. Los enfoques individuales brindan una descripción mucho más detallada de los tumores, pero tienen dificultades cuando se trata de tratar cánceres reales de tamaño completo. Por lo tanto, existe un compromiso entre la integración de información macroscópica y microscópica, ahora ampliamente disponible, y la capacidad de alcanzar tamaños de tumores clínicos. En este documento, presentamos un marco de simulación mesoscópica estocástica que incorpora procesos celulares clave durante la progresión del tumor y mantiene los costos computacionales al mínimo. Nuestro marco captura una escala física que permite la incorporación de información microscópica, el seguimiento de la aparición espacio-temporal de la heterogeneidad tumoral y la dinámica evolutiva subyacente, y la reconstrucción de tumores de tamaño clínico a partir de datos de imágenes médicas de alta resolución, con el beneficio adicional de bajo costo computacional. Ilustramos la funcionalidad de nuestro enfoque de modelado para el caso del glioblastoma, un paradigma de heterogeneidad tumoral que sigue siendo extremadamente desafiante en el entorno clínico. Nuestro marco captura una escala física que permite la incorporación de información microscópica, el seguimiento de la aparición espacio-temporal de la heterogeneidad tumoral y la dinámica evolutiva subyacente, y la reconstrucción de tumores de tamaño clínico a partir de datos de imágenes médicas de alta resolución, con el beneficio adicional de bajo costo computacional. Ilustramos la funcionalidad de nuestro enfoque de modelado para el caso del glioblastoma, un paradigma de heterogeneidad tumoral que sigue siendo extremadamente desafiante en el entorno clínico. Nuestro marco captura una escala física que permite la incorporación de información microscópica, el seguimiento de la aparición espacio-temporal de la heterogeneidad tumoral y la dinámica evolutiva subyacente, y la reconstrucción de tumores de tamaño clínico a partir de datos de imágenes médicas de alta resolución, con el beneficio adicional de bajo costo computacional. Ilustramos la funcionalidad de nuestro enfoque de modelado para el caso del glioblastoma, un paradigma de heterogeneidad tumoral que sigue siendo extremadamente desafiante en el entorno clínico.
- Published
- 2021
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