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2. Use of pulmonary ultrasound to predict in-hospital mortality in patients with COVID-19 infection

Author

Esteban I. Chango-Criollo, Daniel Manzur-Sandoval, Rodrigo Zebadua-Torres, Gastón Mendoza-Copa, Arturo Garza-de la Maza, Edgar García-Cruz, Ricardo Leopoldo Barajas-Campos, Gabriela Ramírez-Galindo, Edith Ramírez-Lara, Rafael Rascón-Sabido, Diego Araiza-Garaygordobil, Rodrigo Gopar-Nieto, and Gustavo Rojas-Velasco

Subjects
Male, medicine.medical_specialty, COVID 19. Ecografía pulmonar. Mortalidad, Critical Care, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, law.invention, law, Internal medicine, medicine, Humans, In patient, Hospital Mortality, Lung, Aged, Ultrasonography, Mechanical ventilation, In hospital mortality, business.industry, Ultrasound, Hazard ratio, COVID-19, General Medicine, Middle Aged, RC31-1245, Respiration, Artificial, Intensive care unit, Hospitalization, Intensive Care Units, medicine.anatomical_structure, Point-of-Care Testing, Female, Public aspects of medicine, RA1-1270, business
Abstract

Lung ultrasound (LUS) implementation in patients with COVID-19 can help to establish the degree of pulmonary involvement, evaluate treatment response and estimate in-hospital outcome.To evaluate the application of a LUS protocol in patients with COVID-19 infection to predict in-hospital mortality.The study was carried out from April 1 to August 1, 2020 in patients with COVID-19 infection admitted to the Intensive Care Unit. Lung evaluation was carried out by physicians trained in critical care ultrasonography.Most patients were males, median age was 56 years, and 59 % required mechanical ventilation. In-hospital mortality was 39.4 %, and in those with a LUS score ≥ 19, mortality was higher (50 %). The multiple logistic regression model showed that a LUS score ≥ 19 was significantly associated with mortality (hazard ratio = 2.55, p = 0.01).LUS is a safe and fast clinical tool that can be applied at bedside in patients with COVID-19 infection to establish the degree of parenchymal involvement and predict mortality.La implementación del ultrasonido pulmonar (LUS) en los pacientes con COVID-19 puede ayudar a establecer el grado de afectación pulmonar, evaluar la respuesta al tratamiento y estimar el desenlace intrahospitalario.Evaluar la aplicación de un protocolo LUS en pacientes con infección por COVID-19 para predecir mortalidad intrahospitalaria.El estudio se realizó del 1 de abril al 1 de agosto de 2020 en pacientes con infección por COVID-19, ingresados en la Unidad de Terapia Intensiva. Se realizó evaluación pulmonar por médicos entrenados en ultrasonografía crítica.La mayoría de los pacientes fue del sexo masculino, la edad mediana fue de 56 años y 59 % requirió ventilación mecánica. La mortalidad intrahospitalaria fue de 39.4 % y en aquellos con puntuación de LUS ≥ 19, de 50 %. El modelo de regresión logística múltiple mostró que la puntuación de LUS ≥ 19 se asoció significativamente a mortalidad (cociente de riesgo = 2.55, p = 0.01).El LUS es una herramienta clínica segura y rápida que puede realizarse al lado de la cama de los pacientes con infección por COVID-19, para establecer el grado de afectación parenquimatosa y predecir la mortalidad.

Published
2023
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4. Evolution of genome space occupation in ferns: linking genome diversity and species richness

Author

Ilia J. Leitch, Tao Fujiwara, Atsushi Ebihara, Rita Morero, Esteban I Meza-Torres, Zhen-Long Liang, Hong-Mei Liu, Harald Schneider, and Alvaro Jose Vega

Subjects
Genome evolution, biology, Phylogenetic tree, Evolutionary biology, Phylogenetics, Species diversity, Plant Science, Species richness, Fern, biology.organism_classification, Genome size, Genome
Abstract

Background and Aims The dynamics of genome evolution caused by whole genome duplications and other processes are hypothesized to shape the diversification of plants and thus contribute to the astonishing variation in species richness among the main lineages of land plants. Ferns, the second most species-rich lineage of land plants, are highly suitable to test this hypothesis because of several unique features that distinguish fern genomes from those of seed plants. In this study, we tested the hypothesis that genome diversity and disparity shape fern species diversity by recording several parameters related to genome size and chromosome number. Methods We conducted de novo measurement of DNA C-values across the fern phylogeny to reconstruct the phylogenetic history of the genome space occupation in ferns by integrating genomic parameters such as genome size, chromosome number and average DNA amount per chromosome into a time-scaled phylogenetic framework. Using phylogenetic generalized least square methods, we determined correlations between chromosome number and genome size, species diversity and evolutionary rates of their transformation. Key Results The measurements of DNA C-values for 233 species more than doubled the taxon coverage from ~2.2 % in previous studies to 5.3 % of extant diversity. The dataset not only documented substantial differences in the accumulation of genomic diversity and disparity among the major lineages of ferns but also supported the predicted correlation between species diversity and the dynamics of genome evolution. Conclusions Our results demonstrated substantial genome disparity among different groups of ferns and supported the prediction that alterations of reproductive modes alter trends of genome evolution. Finally, we recovered evidence for a close link between the dynamics of genome evolution and species diversity in ferns for the first time.

Published
2021
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5. Estados protetores e agressores na sociedade mundial: os efeitos sociais da Covid19

Author

Esteban I. Meza Torres

Subjects
2019-20 coronavirus outbreak, Social processes, Coronavirus disease 2019 (COVID-19), Political science, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Social change, Social power, General Medicine, Humanities
Abstract

DOI: 10.1590/2179-8966/2020/52886 Resumo A crise sociossanitaria gerada pela proliferacao da Covid19 esta produzindo uma transformacao do estado na sociedade mundial, recriando duas formas inovadoras: a do estado protetor e a do estado agressor. Neste trabalho, sustentarei que essa transformacao e principalmente o produto de um fluxo massivo de delegacao do poder social provocado por um movimento mundial de autopreservacao social. A expansao da funcao protetora do estado, por sua vez, esta coproduzindo em tempo recorde uma nova legitimidade politica de excecao, que impacta o campo popular e o campo elitista da sociedade mundial. O artigo identifica os novos aspectos sociopoliticos que trazem com eles a presente conjuntura, bem como as principais continuidades e rupturas relacionadas aos processos sociais envolvidos. Palavras-chave: Mudanca social; Covid-19; Estado; Legitimidade; America Latina; Sociedade mundial. Abstract The socio-health crisis generated by the proliferation of Covid19 is producing a transformation of the state into world society, recreating two innovative forms: that of the protective state and that of the aggressor state. In this work, I will argue that this transformation is mainly the product of a massive flow of delegation of social power fostered by a worldwide movement of social self-preservation. The expansion of the state's protective function, in turn, is coproducing in record time a new exceptional political legitimacy, which impacts the popular and elitist fields of world society. The article identifies the new socio-political aspects that bring with them the current conjuncture, as well as the main continuities and ruptures related to the social processes involved. Keywords: Social change; Covid-19; State; Legitimacy; Latin America; World society.

Published
2021
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6. MicroBooNE and the <math><mrow><msub><mrow><mi>ν</mi></mrow><mrow><mi>e</mi></mrow></msub></mrow></math> Interpretation of the MiniBooNE Low-Energy Excess

Author

Argüelles, C. A., Esteban, I., Hostert, M., Kelly, K. J., Kopp, J., Machado, P. A. N., Martinez-Soler, I., and Perez-Gonzalez, Y. F.

Abstract

A new generation of neutrino experiments is testing the 4.7σ anomalous excess of electronlike events observed in MiniBooNE. This is of huge importance for particle physics, astrophysics, and cosmology, not only because of the potential discovery of physics beyond the standard model, but also because the lessons we will learn about neutrino-nucleus interactions will be crucial for the worldwide neutrino program. MicroBooNE has recently released results that appear to disfavor several explanations of the MiniBooNE anomaly. Here, we show quantitatively that MicroBooNE results, while a promising start, unquestionably do not probe the full parameter space of sterile neutrino models hinted at by MiniBooNE and other data, nor do they probe the νe interpretation of the MiniBooNE excess in a model-independent way.

Published
2022

7. Sticherus lanuginosus (Gleicheniaceae, Polypodiopsida) en Argentina y Paraguay

Author

Hector Alejandro Keller, Esteban I Meza-Torres, and Saúl Páez

Subjects
Plant Science
Abstract

This work provides data on the distribution of Sticherus lanuginosus in Argentina and Paraguay. A description, illustrations, ecological observations and the first record of this species in Argentina are also provided. With this, the number of species of the genus in Argentina rises to three.

Published
2021
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8. Patient Satisfaction Index and Quality of Life Measurement with Breast-Q after Breast Reconstruction in a Plastic Surgery Center in Mexico

Author

Carlos I. Navarro-Delgadillo, Jose Carlos Martinez-Lopez, Jaime Aron Garcia-Espinoza, Victor H. Avalos-Gómez, Rodrigo Davila-Diaz, Cuahutemoc Márquez-Espriella, David Flores-Soto, and Esteban I. Campos-Serna

Subjects
medicine.medical_specialty, business.industry, General surgery, medicine.medical_treatment, medicine.disease, Patient satisfaction, Breast cancer, Quality of life, Management of Technology and Innovation, Patient experience, medicine, Patient-reported outcome, skin and connective tissue diseases, Breast reconstruction, business, Psychosocial, Mastectomy
Abstract

Introduction: Cancer is one of the most devastating pathologies to affect the breast. Mastectomy stigmas are associated with depression, body image dysmorphia, and decreasing quality of life. BREAST-Q is a PROM (Patient Reported Outcome Measures) that has proven useful in measuring satisfaction with breast reconstruction results from the patient’s point of view. Objectives: To measure the satisfaction index and improvement in quality of life after breast reconstruction for breast cancer sequelae in our hospital in the last 5 years. Materials and Methods: Descriptive Study that includes patients with Breast cancer diagnosis that underwent mastectomy and breast reconstruction (prosthesis or autologous tissue) in “Hospital Central Sur de Petroleos Mexicanos” (January 2015 to January 2020), whose satisfaction index was measured with BREAST-Q one year after reconstruction. Results: 153 patients were included in the analysis. Mean global satisfaction was 74 points. We observed a tendency towards higher psychosocial, sexual and appearance satisfaction in patients who underwent reconstruction with autologous tissue. The mean satisfaction with provided information was 64 points and with the medical team > 90 points. Conclusion: Breast reconstruction is associated to a high satisfaction index and quality of life improvement regardless of the technique. BREAST-Q proved to be useful in evaluating patient experience and it helped us identify areas of opportunity to improve our care.

Published
2021
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9. Impact of N-acetylcysteine (NAC) and calcium hydroxide intracanal medications in primary endodontic infection: a randomized clinical trial

Author

Frederico C, Martinho, Bruna J M, Corazza, Rayana D, Khoury, Esteban I F, Orozco, Cassia C, Toia, Felipe P, Machado, and Marcia C, Valera

Abstract

This RCT investigated the impact of N-acetylcysteine (NAC) and calcium hydroxide [Ca(OH)Thirty-six teeth with PEIAP were randomly divided into groups according to the ICM: NAC, Ca(OH)At s1, bacterial DNA was detected in 100% of RCSs (36/36). All 40 bacterial species were found in PEIAP. The mean number of species per RCS was 17.92 ± 13.18. The most frequent bacteria were S. mitis (65%), E. nodatum (63%), E. faecalis (63%), F. nucl sp vicentii (58%), T. forsythia (58%), and F. periodonticum (56%). CMP reduced the mean number of species per RCS to 6.8 ± 2.36 (p 0.05). At s3, the intragroup analysis revealed a broader antimicrobial activity for Ca (OH)Ca (OH)2 + 2% chlorhexidine gel (2% CHX gel) showed a greater bacterial elimination over the number of bacterial species; however, NAC eliminated 8/12 bacteria species resistant to both Ca (OH)2 ICMs (RBR-3xbnnn).The use of intracanal medication with a broad antimicrobial activity can optimize root canal disinfection. Ca(OH)Brazilian Registry of Clinical Trials (REBEC), No. RBR-3xbnnn.

Published
2022

10. Comparison of FCS-MPC Strategies in a Grid-Connected Single-Phase Quasi-Z Source Inverter

Author

Jorge L. Saavedra, Carlos R. Baier, Esteban I. Marciel, Marco Rivera, Alvaro Carreno, Jesús C. Hernandez, and Pedro E. Melín

Subjects
predictive control, FCS-MPC, long prediction horizon, single-phase quasi-Z source inverter, SP-qZSI, Computer Networks and Communications, Hardware and Architecture, Control and Systems Engineering, Signal Processing, Electrical and Electronic Engineering
Abstract

This paper compares two finite-control-set model predictive control (FCS-MPC) strategies in the context of a grid-connected single-phase quasi-Z source inverter (SP-qZSI). Both schemes use discrete-time models of the inductor current and capacitor voltage for the DC side, as well as the output current on the AC side. To enhance the converter’s performance, given the non-minimum phase characteristics of the DC side, a long prediction horizon is implemented for the predictive control. However, a horizon of this nature can be highly demanding in terms of processing load, rendering it inapplicable for some microcontrollers. To address this issue and mitigate the processing load, an alternative control strategy is presented that divides the total number of candidate solutions to be evaluated into smaller segments. The performance of the two control strategies is compared using total harmonic distortion (THD) and simulation times as evaluation metrics. The results indicate that the proposed strategy achieves significantly shorter simulation times than the compared control strategy when increasing the prediction horizon. Additionally, a reduction in the THD was observed in the proposed strategy, reaching an average of 2.8%, which is lower than the compared strategy that exhibited THD close to 3.5%.

Published
2023
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11. Estratègies d’aula inversa basades en eines web 2.0 per a la millora del procés d’aprenentatge de l’estudiant

Author

Serrano i Plana, Núria, Ayala Cabrera, Juan Francisco, Díaz Cruz, José Manuel, Esteban i Cortada, Miquel, Garcia Amorós, Jaume, Núñez Burcio, Oscar, Pérez Rafols, Clara, Ramírez Rangel, Eliana, and Subirats i Vila, Xavier

Subjects
Web 2.0, Aprenentatge, Classe inversa, Innovacions educatives
Abstract

Codi del Projecte: 2018PID-UB/029, Es presenta com a informe final la difusió portada a terme en el marc del projecte d’innovació docent “Estratègies d’aula inversa basades en eines web 2.0 per a la millora del procés d’aprenentatge de l’estudiant” (2018PID-UB/029). El projecte se centra en el desenvolupament i implementació de noves metodologies docents fonamentades en estratègies d’aula inversa basades en eines web 2.0 que potenciïn l’ús i l’aplicació de les TIC en la nostra activitat docent per garantir el correcte seguiment de l’avaluació continuada de l’estudiant i de l’assoliment de les competències de l’assignatura, fomentar la motivació i participació a classe de l’estudiant, a més de facilitar-ne una retroacció activa, àgil i constant, en definitiva, millorar-ne el seu procés d’aprenentatge

Published
2022

12. Downscaling estadístico a muy alta resolución espacial de las proyecciones climáticas de cubierta de nieve para los Pirineos

Author

Lemus-Cánovas, Marc, Trapero, Laura, Albalat, Anna, Pons, Marc, Alonso González, Esteban, Esteban i Vea, Pere, Martín-Vide, Javier, Gascoin, Simon, and López Moreno, Juan Ignacio

Subjects
Statistical downscaling, MODIS, Cubierta de nieve, Downscaling estadístico, CMIP6, Snow cover
Abstract

Ponencia presentada en: XII Congreso de la Asociación Española de Climatología celebrado en Santiago de Compostela entre el 19 y el 21 de octubre de 2022. [ES]El estudio de la evolución de la cubierta de nieve ha centrado la atención de diversas investigaciones en el área de los Pirineos. La gran mayoría de estos estudios tratan de calcular las tendencias o cambios observados hasta ahora en esta variable. En el presente trabajo se realiza el downscaling estadístico a 1km de resolución espacial de una serie de modelos climáticos derivados del 6º Coupled Model Intercomparison Project (CMIP6), con el objetivo de proyectar la cubierta de nieve –presencia o ausencia de esta, a partir de las imágenes satelitales capturadas por el sensor MODIS– a nivel diario, y empleando distintos escenarios de cambios socioeconómicos globales proyectados hasta 2100 a 1km de resolución espacial. Los primeros resultados plantean una drástica reducción de los días con cubierta de nieve en toda la cordillera, siendo esta muy notable a final de siglo bajo el escenario SSP5-8.5, implicando temporadas de cubierta de nieve con una duración de 50 días en la vertiente sur para una franja altitudinal de 1600-2000 m s.n.m, contrastando con los 100-150 días contabilizados de media en el período 2001-2014, para este mismo estrato altitudinal. Otro resultado destacado es la práctica desaparición de la cubierta de nieve a principios y finales de temporada, bajo un escenario intermedio (SSP5-4.5) y de elevadas emisiones de gases de efecto invernadero (SSP5-8.5), lo que indica un claro acortamiento de la temporada de nieve para toda la cordillera y supondrá una importante reducción de los aportes hídricos provenientes del manto nival durante la primavera y el periodo estival. [EN]The evolution of the snow cover has been the focus of several studies in the Pyrenees. The vast majority of these studies attempted to estimate the recent trends or the observed changes in this variable. In the present work, statistical downscaling is performed at 1 km spatial resolution for a set of climate models derived from the 6th Coupled Model Intercomparison Project (CMIP6), with the aim of projecting snow cover - presence or absence, based on satellite images captured by the MODIS sensor - at a daily level, and using different socio-economic global change scenarios projected up to 2100. The first results show a drastic reduction in the number of days with snow cover in the entire mountain range, being very noticeable at the end of the century under the SSP5-8.5 scenario, implying snow cover seasons with a duration of 50 days on the southern slope for an altitudinal range of 1600-2000 masl, in contrast with the 100-150 days recorded on average in the period 2001-2014, for the same altitudinal range. Another remarkable result is the virtual disappearance of snow cover at the beginning and end of the season, under an intermediate scenario (SSP5-4.5) and high greenhouse gas emissions (SSP5-8.5), which indicates a clear shortening of the snow season for this area and will lead to a significant reduction in water inputs from the snowpack during the spring and summer period. La presente investigación se ha realizado en el marco del Grupo de Climatología de la Universidad de Barcelona (2017 SGR 1362, Generalitat de Catalunya), y del proyecto EXE (PID2020-116860RB-C21) financiado por el Ministerio de Ciencia e Innovación.

Published
2022

13. Snowmass White Paper: Beyond the Standard Model effects on Neutrino Flavor

Author

Argüelles, C. A., Barenboim, G., Bustamante, M., Coloma, P., Denton, P. B., Esteban, I., Farzan, Y., Martínez, E. Fernández, Forero, D. V., Gago, A. M., Katori, T., Lehnert, R., Ross-Lonergan, M., Suliga, A. M., Tabrizi, Z., Anchordoqui, L., Chakraborty, K., Conrad, J., Arindam Das, Fong, C. S., Littlejohn, B. R., Maltoni, M., Parno, D., Spitz, J., Tang, J., Wissel, S., European Commission, Ministerio de Ciencia e Innovación (España), and Agencia Estatal de Investigación (España)

Subjects
HIGH-ENERGY NEUTRINO, MAGNETIC-MOMENT, STERILE NEUTRINOS, QUANTUM DECOHERENCE, COSMIC-RAY NEUTRINOS, High Energy Physics::Phenomenology, SUPERNOVA NEUTRINOS, FOS: Physical sciences, High Energy Physics - Experiment, High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), ELECTRON NEUTRINO, DARK-MATTER, High Energy Physics::Experiment, CORE-COLLAPSE, NONSTANDARD INTERACTIONS
Abstract

Neutrinos are one of the most promising messengers for signals of new physics Beyond the Standard Model (BSM). On the theoretical side, their elusive nature, combined with their unknown mass mechanism, seems to indicate that the neutrino sector is indeed opening a window to new physics. On the experimental side, several long-standing anomalies have been reported in the past decades, providing a strong motivation to thoroughly test the standard three-neutrino oscillation paradigm. In this Snowmass21 white paper, we explore the potential of current and future neutrino experiments to explore BSM effects on neutrino flavor during the next decade., CAA is supported by the Faculty of Arts and Sciences of Harvard University, and the Alfred P. Sloan Foundation. GB acknowledges support from AEI-MICINN PID2020-113334GBI00 / AEI / 10.13039/501100011033. MB is supported by the Villum Fonden under project no. 29388. PC acknowledges support by Grants CEX2020-001007-S, PID2019-108892RB-I00 and RYC2018- 024240-I funded byMCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”. YF has received financial support from Saramadan under contract No. ISEF/M/400279 and No. ISEF/M/99169. TK acknowledges the support from the Science and Technology Council Facilities, UK. AMS acknowledges the support of US National Science Foundation (Grant No. PHY-2020275). This project has received funding/support from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 860881-HIDDeN. This white paper has been prepared in the context of the Snowmass’21 Community Planning exercise, as part of the activities coordinated by the NF03 subtopical group (neutrinos and BSM). It summarizes present and future opportunities to search for effects due to new physics in neutrino flavour conversion. Coordinated by Coloma, Forero and Katori. The white paper has two main parts, theoretical aspects and experimental overview and prospects. Sections are led by a wide set of researchers. On the theoretical side, we discuss the new physics in the additional neutrino states (Fernández Martínez, Forero), new interactions (Coloma, Farzan, Tabrizi), neutrino decay (Bustamante, Denton, Gago), and fundamental physics principles (Barenboim, Katori, Lehnert). On the experimental side, discussions go to different neutrino energy scales, from below GeVs (Esteban, Suliga), GeV to TeV scales (Forero, Ross-Lonergan), and beyond TeVs (Argüelles, Katori).

Published
2022
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14. MicroBooNE and the $\nu_e$ Interpretation of the MiniBooNE Low-Energy Excess

Author

Argüelles, C. A., Esteban, I., Hostert, M., Kelly, K. J., Kopp, J., Machado, P. A. N., Martinez-Soler, I., and Perez-Gonzalez, Y. F.

Subjects
High Energy Physics - Phenomenology, Astrophysics and Astronomy, hep-ex, High Energy Physics::Phenomenology, astro-ph.CO, High Energy Physics::Experiment, hep-ph, Particle Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, Particle Physics - Phenomenology
Abstract

A new generation of neutrino experiments is testing the $4.8\sigma$ anomalous excess of electron-like events observed in MiniBooNE. This is of huge importance for particle physics, astrophysics, and cosmology, not only because of the potential discovery of physics beyond the Standard Model, but also because the lessons we will learn about neutrino-nucleus interactions will be crucial for the worldwide neutrino program. MicroBooNE has recently released results that appear to disfavor several explanations of the MiniBooNE anomaly. Here, we show quantitatively that MicroBooNE results, while a promising start, unquestionably do not probe the full parameter space of sterile neutrino models hinted at by MiniBooNE and other data, nor do they probe the $\nu_e$ interpretation of the MiniBooNE excess in a model-independent way. Our analysis code is fully available in https://github.com/Harvard-Neutrino/MicroBooNE-analysis-2021., Comment: 7+6 pages, 5+9 figures. v2: version published in Phys.Rev.Lett. New supplemental material with test statistic coverage checks, validation of unfolding method, and Asimov sensitivity comparison. Typos and mislabeling fixed

Published
2021

15. Pressure-induced enhancement of the superconducting transition temperature in La2O2Bi3AgS6

Author

Esteban I. Paredes Aulestia, Xinyou Liu, Swee K. Goh, Wing Chi Yu, Yiu Yung Pang, Kwing To Lai, and Chun Wa So

Subjects
Superconductivity, Materials science, Condensed matter physics, Strongly Correlated Electrons (cond-mat.str-el), Condensed Matter - Superconductivity, FOS: Physical sciences, Condensed Matter Physics, Instability, Superconductivity (cond-mat.supr-con), Condensed Matter - Strongly Correlated Electrons, Electrical resistivity and conductivity, Pairing, Condensed Matter::Superconductivity, General Materials Science, Cuprate, Condensed Matter::Strongly Correlated Electrons, Charge density wave, Phase diagram, Ambient pressure
Abstract

Charge density wave (CDW) instability is often found in phase diagrams of superconductors such as cuprates and certain transition-metal dichalcogenides. This proximity to superconductivity triggers the question on whether CDW instability is responsible for the pairing of electrons in these superconductors. However, this issue remains unclear and new systems are desired to provide a better picture. Here, we report the temperature-pressure phase diagram of a recently discovered BiS$_2$ superconductor La$_2$O$_2$Bi$_3$AgS$_6$, which shows a possible CDW transition at $T^*\sim$155 K and a superconducting transition at $T_c\sim$1.0 K at ambient pressure, via electrical resistivity measurements. Upon applying pressure, $T^*$ decreases linearly and extrapolates to 0 K at 3.9 GPa. Meanwhile, $T_c$ is enhanced and reaches maximum value of 4.1 K at 3.1 GPa, forming a superconducting dome in the temperature-pressure phase diagram., 8 pages, 4 figures. This is the first draft of an accepted paper by J. Phys. Condens. Matter

Published
2021

16. Taphonomy, environment or human plant exploitation strategies?: Deciphering changes in Pleistocene-Holocene plant representation at Umhlatuzana rockshelter, South Africa

Author

Murungi, M., Esteban, I., Sifogeorgakis, E., and Dusseldorp, G.L.

Abstract

The period between ~40 and 20 ka BP encompassing the Middle Stone Age (MSA) and Later Stone Age (LSA) transition has long been of interest because of the associated technological change. Understanding this transition in southern Africa is complicated by the paucity of archaeological sites that span this period. With its occupation sequence spanning the last ~70,000 years, Umhlatuzana Rock Shelter is one of the few sites that record this transition. Umhlatuzana thus offers a great opportunity to study past environmental dynamics from the Late Pleistocene (MIS 4) to the Late Holocene, and past human subsistence strategies, their social organisation, technological and symbolic innovations. Although organic preservation is poor (bones, seeds, and charcoal) at the site, silica phytoliths preserve generally well throughout the sequence. These microscopic silica particles can identify different plant types that are no longer visible at the site because of decomposition or burning to a reliable taxonomical level. Thus, to trace site occupation, plant resource use, and in turn reconstruct past vegetation, we applied phytolith analyses to sediment samples of the newly excavated Umhlatuzana sequence. We present results of the phytolith assemblage variability to determine change in plant use from the Pleistocene to the Holocene and discuss them in relation to taphonomical processes and human plant gathering strategies and activities. This study ultimately seeks to provide a palaeoenvironmental context for modes of occupation and will shed light on past human-environmental interactions in eastern South Africa.

Published
2021

18. Anatomía comparada en cuatro helechos Cheilantoideos

Author

M. Stella Solís, Bruno Dematteis Bruno, Jovita C. Yesilyurt, and Esteban I. Meza Torres

Subjects
0106 biological sciences, 0303 health sciences, biology, Cheilanthes, Doryopteris, Plant Science, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, pecíolo, lcsh:QK1-989, 03 medical and health sciences, mesófilo, lcsh:Botany, anatomía, Adiantopsis, lcsh:Q, lcsh:Science, Humanities, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology
Abstract

Introducción y objetivos: Algunas especies de helechos cheilanthoideos son caracterizados por presentar adaptaciones a hábitats xéricos. Además, presentan la particularidad de enrollar sus láminas frente a condiciones de stress hídrico. Sin embargo, al retornar las condiciones ambientales óptimas las láminas se vuelven a expandir. El objetivo de este trabajo es proporcionar información morfo-anatómica de las frondes y asociar estructuras anatómicas a estos movimientos foliares.M&M: Se estudiaron mediante microscopía óptica y electrónica de barrido la morfo-anatomía de las frondes de cuatro especies: Adiantopsis radiata, Cheilanthes glauca, Doryopteris concolor, y D. pentagona. Además, se analizó la densidad de los estomas y se calculó el índice estomático.Resultados: Se observó mesófilo homogéneo en A. radiata y D. pentagona. Cheilanthes glauca y Doryopteris concolor presentaron mesófilo heterogéneo dorsiventral. Todas las especies mostraron hojas hipoestómaticas y estomas de tipo anomocítico. El índice estomático osciló entre 9,1% (A. radiata) y 14,1% (D. concolor) y el rango de densidad de los estomas fue de 39,7 (D. pentagona) y 57,8 (D. concolor).Conclusiones: El mesófilo observado en A. radiata y D. pentagona refleja la especialización para habitar ambientes mesófilos. El mesófilo heterogéneo dorsiventral de Doryopteris concolor podría ser una ventaja para su hábito epifítico facultativo. Cheilanthes glauca tiene características xeromorfas y mesomorfas, probablemente como resultado de la disponibilidad de agua en el ambiente durante las diferentes estaciones. Se propone como hipótesis que el engrosamiento de las paredes anticlinales de las células epidérmicas podría estar involucrados en los movimientos de las láminas.

Published
2019
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19. Pressure-induced enhancement of the superconducting transition temperature in La

Author

Esteban I, Paredes Aulestia, Xinyou, Liu, Yiu Yung, Pang, Chun Wa, So, Wing Chi, Yu, Swee K, Goh, and Kwing To, Lai

Abstract

Charge density wave (CDW) instability is often found in phase diagrams of superconductors such as cuprates and certain transition-metal dichalcogenides. This proximity to superconductivity triggers the question on whether CDW instability is responsible for the pairing of electrons in these superconductors. However, this issue remains unclear and new systems are desired to provide a better picture. Here, we report the temperature-pressure phase diagram of a recently discovered BiS

Published
2021

20. Sensores electroquímicos para la detección de contaminantes y la autentificación de alimentos

Author

Tapia, María A., Pérez Ràfols, Clara, Serrano i Plana, Núria, Díaz Cruz, José Manuel, Ariño Blasco, Cristina, and Esteban i Cortada, Miquel

Subjects
Qualitat dels aliments, Pollutants, Anàlisi electroquímica, Contaminants, Electrochemical analysis, Food quality
Abstract

En este artículo resumiremos las últimas líneas de investigación del grupo, enmarcadas en la estrategia general de desarrollarsistemas de sensores económicos, sensibles y fiables que en un futuro puedan ser implementados en redes de control inalámbricas en ámbitos de creciente interés social, como la gestión del agua en un contexto de cambio climático o el control y la seguridad de los productos alimentarios.

Published
2021

21. Uso de ultrasonido pulmonar para predecir mortalidad intrahospitalaria en pacientes con infección por COVID-19

Author

Gastón Mendoza-Copa, Gabriela Ramírez-Galindo, Gustavo Rojas-Velasco, Edgar García-Cruz, Rodrigo Gopar-Nieto, Rafael Rascón-Sabido, Diego Araiza-Garaygordobil, Arturo Garza-de la Maza, Ricardo Leopoldo Barajas-Campos, Esteban I. Chango-Criollo, Daniel Manzur-Sandoval, Edith Ramírez-Lara, and Rodrigo Zebadua-Torres

Subjects
Mechanical ventilation, medicine.medical_specialty, Treatment response, Lung, business.industry, medicine.medical_treatment, Hazard ratio, General Medicine, Intensive care unit, law.invention, Lung ultrasound, medicine.anatomical_structure, law, Internal medicine, medicine, In patient, Ultrasonography, business
Abstract

Introduction: Lung ultrasound (LUS) implementation in patients with COVID-19 can help to establish the degree of pulmonary involvement, evaluate treatment response and estimate in-hospital outcome. Objective: To evaluate the application of LUS in patients with COVID-19 infection to predict in-hospital mortality. Methods: The study was carried out from April 1 to August 1, 2020 in patients with COVID-19 infection admitted to the Intensive Care Unit. Lung evaluation was carried out by physicians trained in critical care ultrasonography. Results: Most patients were males, median age was 56 years, and 59 % required mechanical ventilation. In-hospital mortality was 39.4 %, and in those with a LUS score ≥ 19, mortality was higher (50 %). The multiple logistic regression model showed that a LUS score ≥ 19 was significantly associated with mortality (hazard ratio = 2.55, p = 0.01). Conclusions: LUS is a safe and fast clinical tool that can be applied at bedside in patients with COVID-19 infection to establish the degree of parenchymal involvement and predict mortality.

Published
2021
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22. Desensibilización con idursulfase en un niño con síndrome de Hunter (mucopolisacaridosis ii)

Author

Esteban I Garramone, Lucrecia Bustamante, Luciano Garavaglia, Hernan Amartino, and Claudio As Parisi

Subjects
medicine.medical_specialty, Idursulfase, business.industry, medicine.medical_treatment, Hunter syndrome, Enzyme replacement therapy, medicine.disease, Culprit, Quality of life, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Adverse effect, business, Anaphylaxis, medicine.drug, Desensitization (medicine)
Abstract

Enzyme replacement therapy with idursulfase decreases morbidity and improves quality of life of patients with mucopolysaccharidosis ii. Immediate hypersensitivity reactions to this drug have been described. Desensitization is a treatment that induces temporary tolerance to a culprit drug, allowing the allergic patient to receive the medication. We present the case of a 7-year-old patient diagnosed with Hunter syndrome who presented, after 4 years of treatment, two episodes of anaphylaxis during the infusion of idursulfase. Detection of specific immunoglobulin E was carried out using skin tests, with intradermal reaction at a 1/10 dilution (0.2 mg/ml) being positive. A 12-step desensitization protocol was performed without presenting adverse events. The allergological evaluation and the possibility of desensitization were useful tools in the management of our patient.

Published
2021
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23. MicroBooNE and the $ν_e$ Interpretation of the MiniBooNE Low-Energy Excess

Author

Argüelles, C. A., Esteban, I., Hostert, M., Kelly, K. J., Kopp, J., Machado, P. A. N., Martinez-Soler, I., and Perez-Gonzalez, Y. F.

Subjects
High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Cosmology and Nongalactic Astrophysics (astro-ph.CO), High Energy Physics::Phenomenology, FOS: Physical sciences, High Energy Physics::Experiment
Abstract

A new generation of neutrino experiments is testing the $4.8σ$ anomalous excess of electron-like events observed in MiniBooNE. This is of huge importance for particle physics, astrophysics, and cosmology, not only because of the potential discovery of physics beyond the Standard Model, but also because the lessons we will learn about neutrino-nucleus interactions will be crucial for the worldwide neutrino program. MicroBooNE has recently released results that appear to disfavor several explanations of the MiniBooNE anomaly. Here, we show quantitatively that MicroBooNE results, while a promising start, unquestionably do not probe the full parameter space of sterile neutrino models hinted at by MiniBooNE and other data, nor do they probe the $ν_e$ interpretation of the MiniBooNE excess in a model-independent way. Our analysis code is fully available in https://github.com/Harvard-Neutrino/MicroBooNE-analysis-2021., 7+6 pages, 5+9 figures. v2: version published in Phys.Rev.Lett. New supplemental material with test statistic coverage checks, validation of unfolding method, and Asimov sensitivity comparison. Typos and mislabeling fixed

Published
2021
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24. EuCAPT White Paper: Opportunities and Challenges for Theoretical Astroparticle Physics in the Next Decade

Author

Alves Batista, R., Amin, M. A., Barenboim, G., Bartolo, N., Baumann, D., Bauswein, A., Bellini, E., Benisty, D., Bertone, G., Blasi, P., Böhmer, C. G., Bošnjak, Ž., Bringmann, T., Burrage, C., Bustamante, M., Calderón Bustillo, J., Byrnes, C. T., Calore, F., Catena, R., Cerdeño, D. G., Cerri, S. S., Chianese, M., Clough, K., Cole, A., Coloma, P., Coogan, A., Covi, L., Cutting, D., Davis, A. C., Rham, C. de, Matteo, A. di, Domènech, G., Drewes, M., Dietrich, T., Edwards, T. D. P., Esteban, I., Erdem, R., Evoli, C., Fasiello, M., Feeney, S. M., Ferreira, R. Z., Fialkov, A., Fornengo, N., Gabici, S., Galatyuk, T., Gaggero, D., Grasso, D., Guépin, C., Harz, J., Herrero-Valea, M., Hinderer, T., Hogg, N. B., Hooper, D. C., Iocco, D., Isern, J., Karchev, K., Kavanagh, B. J., Korsmeier, M., Kotera, K., Koyama, K., Krishnan, B., Lesgourgues, J., Levi Said, J., Lombriser, L., Lorenz, C. S., Manconi, S., Mapelli, M., Marcowith, A., Markoff, S. B., Marsh, D. J., Martinelli, M., Martinsolami, C. J. A. P., Millington, P., Moesta, P., Nippel, K., Niro, V., O'Connor, E., Oikonomou, F., Paganini, C. F., Pagliaroli, G., P. Pani, P., Pfrommer, C., Pascoli, S., Pinol, L., Pizzuti, L., Porto, R. A., Pound, A., Quevedo, F., Raffelt, G. G., Raccanelli, A., Ramirez-Ruiz, E., Raveri, M., Renaux-Petel, S., Ricciardone, A., Rida Khalifeh, A., Riotto, A., Roiban, R., Rubio, J., Sahlén, M., Sabti, N., Sagunski, L., Šarčević, N., Schmitz, K., Schwaller, P., Schwetz, T., Sedrakian, A., Sellentin, E., Serenelli, A., Serpico, P. D., Sfakianakis, E. I., Shalgar, S., Silvestri, A., Tamborra, I., Tanidis, K., Teresi, D., Tokareva, A. A., Tolos, L., Trojanowski, S., Trotta, R., Uhlemann, C., Urban, F. R., Vernizzi, F., Vliet, A. van, Villante, F. L., Vincent, A., Vink, J., Vitagliano, E., Weniger, C., Wickenbrock, A., Winter, W., Zell, S., and Zeng, M.

Subjects
Physics, ddc:530
Published
2021
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25. Widespread Presence of Domestic Dogs on Sandy Beaches of Southern Chile

Author

Eduardo A. Silva-Rodríguez, Esteban I Cortés, and Juan G. Navedo

Subjects
shorebirds, dog disturbance, Article, fluids and secretions, Abundance (ecology), lcsh:Zoology, Ecosystem, lcsh:QL1-991, Chile, Recreation, Numenius phaeopus, lcsh:Veterinary medicine, General Veterinary, biology, sandy beaches, Ecology, fungi, technology, industry, and agriculture, Canis familiaris, recreation, biology.organism_classification, Geography, Harassment, lcsh:SF600-1100, Animal Science and Zoology, human activities, geographic locations
Abstract

Simple Summary The presence of dogs on sandy beaches is a concern when it comes to protecting the breeding and migratory stop-over sites of shorebirds. To manage this threat, it is necessary to understand the factors that explain the presence of dogs at sandy beaches. To address this, we conducted a study in southern Chile where we surveyed dogs and their tracks at 14 beaches. Dogs were present on all of them, and we found that their abundance was higher when more people were on the beach and at beaches surrounded by more houses. Furthermore, we detected that, given the opportunity, dogs frequently harassed whimbrels, a long-distance migratory shorebird. Dogs at beaches were often not supervised, and only 13% were on a leash. Although our study shows the association between dogs and people, it identifies that this relationship is not simply one of dogs and their owners; instead, it is free-ranging dogs that are associated with beach-goers and human settlements. Therefore, we suggest that to reduce dog harassment of shorebirds, it is fundamental to reduce the number of unsupervised and unleashed dogs at beaches. Abstract Dogs on sandy beaches are a threat to shorebirds. Managing this problem requires understanding the factors that influence the abundance of dogs in these ecosystems. We aimed to determine the proportion of beaches used by dogs and the effects of human presence on dog abundance on sandy beaches of southern Chile. We conducted dog counts and recorded the presence of tracks on 14 beaches. We used zero-inflated generalized linear mixed models to determine if the number of people, number of households, and other covariates were associated with dog abundance. We detected dog tracks on all the beaches, and dog sightings on most of them. Dogs were frequently not supervised (45%) and only 13% of them were leashed. The number of people on the beach and the number of houses near the beach were positively associated with the number of dogs on beaches. Finally, when dogs co-occurred with whimbrels (Numenius phaeopus), the probability of dog harassment was high (59%). Our work reveals that human presence determines the abundance of dogs on sandy beaches. Therefore, our study suggests that any strategy aiming at reducing dog harassment of shorebirds requires changes in those human behaviors that favor the presence of free-ranging dogs at beaches.

Published
2021

26. Spatio‐temporal patterns of snow in the Catalan Pyrenees (NE Iberia)

Author

Bonsoms, Josep, González Herrero, Sergi, Prohom, Marc, Esteban i Vea, Pere, Salvador, Ferrán, López Moreno, Juan Ignacio, and Oliva, Marc

Subjects
Snow, Teleconnection patterns, Circulation types, Climate variability
Abstract

In a warmer climate, significant variations in the snow regime are expected. Thus, it is crucial to better understand present‐day snow cover regime, its duration and thickness, in order to anticipate future changes. This work presents the first characterization of snow patterns in the Catalan Pyrenees based on 11 snow stations located in high elevation areas (>2,000 m). Here, we examine spatio‐temporal evolution of the daily snow depth and new snow height (HN) since the earliest 2000s to 2020. In addition, we analyse the different synoptic patterns that cause HN events in the study area as well as the low frequency climate modes on the different stages of the snow season. Our results show evidence that the measured snow amount differs considerably between the western and the eastern Catalan Pyrenees independently of the considered elevation. While the eastern part has an average seasonal cumulative HN of 278 cm, the western sector gets almost twice (433 cm). Nonetheless, the onset of the snow melting does not show substantial differences, being primarily ruled by the elevation in both areas. The longest snow records (Núria, 1971 m) point to an increase of HN from 1985 to 2020, a trend which is also observed in most stations from 2000 to 2020. Nevertheless, some stations of the N western fringe record negative trends associated with the low frequency variability of the Western Mediterranean Oscillation (WeMO). Results also indicate that the NW Atlantic low‐pressure systems are the circulation weather types that provide more abundant HN in the majority of snow stations. The Atlantic advections are more frequent in autumn and winter, while the Mediterranean advections provide more intense and recurrent HN in spring. The atmospheric circulation is basically ruled by the East Atlantic/West Russia and the WeMO teleconnection patterns. Ramón y Cajal Research Program, Grant/Award Number: RYC‐2015‐17597.

Published
2021

27. Bases per a la Gestió del Paisatge de la Serra de Tramuntana : 13 propostes i 55 projectes

Author

Nel·lo, Oriol, Cerdán, Rufí, Mendizábal Riera, Enric, Pèlachs Mañosa, Albert, Badia i Perpinyà, Anna, Cebollada Frontera, Àngel, Donat, Carles, Dot Jutglà, Esteve, Rosselló Verger, Vicent Maria, Esteban i Noguera, Juli, Pié Ninot, Ricard, Campillo i Besses, Xavier, Sala Martí, Pere, Font, Joan, Grimalt Gelabert, Miquel, Onofre Rullan, Onofre, Mateu Lladó, Jaume, Dubon, Maria Lluïsa, Bartomeu Deyà, Bartomeu, Rayó, Miquel, Torrens, Sebastià, Sastre, Joan, and Sastre, Vicenç

Subjects
Gestió del paisatge, Serra de Tramuntana (Mallorca, Balears)
Abstract

Màster Oficial en Estudis Territorials i de la Població. Departament de Geografia, Universitat Autònoma de Barcelona, Programa troncal 2013-2014, Gener 2014 Coordinació projecte Troncal: Oriol Nel·lo Colom Mòduls docents: Ordenació, Planejament i Gestió del Territori: Oriol Nel·lo Colom, Rufí Cerdán Heredia -- Temes Avançats: Enric Mendizàbal Riera, Albert Pèlachs Mañosa -- Sistemes d'Informació Geogràfica, Planejament i Paisatge: Anna Badia Perpinyà, Albert Pèlachs Mañosa -- Ciutat i Espais Metropolitans: Àngel Cebollada Frontera, Carles Donat Muñoz Coordinació continguts: Esteve Dot Jutgla Conferenciants: Vicent Maria Rosselló Verger, Juli Esteban Noguera, Ricard Pié Ninot, Xavier Campillo Besses, Pere Sala Martí, Joan Nogué Font Conferenciants de Mallorca: Miquel Grimalt (Director del Departament de Ciències de la Terra, Universitat de les Illes Balears), Onofre Rullan (Departament de Ciències de la Terra, Universitat de les Illes Balears), Jaume Mateu (Departament de Ciències de la Terra,Universitat de les Illes Balears), Maria Lluïsa Dubon (geògrafa), Bartomeu Deyà (Director gerent del Consorci Serra de Tramuntana Patrimoni Mundial), Miquel Rayó (escriptor), Sebastià Torrens (fotògraf), Joan Sastre (escriptor), Vicenç Sastre (escriptor) Redactors: Grup1: Sara González Pérez, Antón Magarolas Navarro, Ilaria Sanna -- Grup2: Giulia Garolla, Alberto Innocenti, Javier Martín Úceda, Dalila Serusi -- Grup 3: Francesco Finotto, Maria Lidmäe, Sara Serilli, María Torres Bagur -- Grup 4: Giulia Battiston, Sergi Del Olmo Parisi, Elena Vettoretti, Rafael Vicente Salar -- Grup 5: Roberta Fadda, Daniela Pinna, Gloria Veloz, Francesc Vila Palà -- Grup 6: Fernanda Avellaneda Viteri, Giulia Cubadda, Xavier Delclòs Alió, Francesco Luigi Ferrari El Màster d'Estudis Territorials i de la Població és un programa de postgrau del Departament de Geografia de la Universitat Autònoma de Barcelona que té per objectiu la formació de professionals en el camp de la demografia, el planejament i l'ordenació del territori. En el seu itinerari d'Estudis Territorials, el programa ofereix una orientació essencialment aplicada, de tal manera que inclou un exercici troncal en el que els participants elaboren, en equip, amb finalitats didàctiques i sota la direcció dels docents, un document de planejament que compta amb tots els elements d'una proposta professional de planejament. Enguany, el tema escollit per a l'exercici troncal ha estat el reconeixement territorial i la redacció d'una proposta per a la gestió del paisatge de la Serra de Tramuntana de Mallorca. El document que teniu a les mans és el resultat de l'exercici, en el qual 23 alumnes, procedents de 4 països diversos, dividits en 6 equips, i sota la direcció de 10 professors, han redactat efectivament unes Bases per a la Gestió del Paisatge de la Serra de Tramuntana. El document resultant, conté, tal com s'ha indicat, tots els elements propis d'un document d'ordenació del territori: Memòria, Valoració, Diagnosi, Objectius, Propostes i Projectes. D'acord amb les característiques del programa, l'exercici s'ha realitzat a partir d'una voluntat d'integració dels continguts, transversalitat de les propostes, contextualització dels ensenyaments teòrics i un mètode aplicat, en el que han tingut un paper central el treball de camp i el treball en grup. Per això, s'han integrat els quatre mòduls que configuren el primer semestre del Màster en un sol programa i calendari d'ensenyaments i activitats, d'acord amb allò que figura en el Quadern Troncal que podreu trobar al final d'aquest volum.

Published
2021

28. Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study

Author

Gaba, F, Blyuss, O, Chandrasekaran, D, Osman, M, Goyal, S, Gan, C, Izatt, L, Tripathi, V, Esteban, I, McNicol, L, Ragupathy, K, Crawford, R, Evans, DG, Legood, R, Menon, U, and Manchanda, R

Abstract

OBJECTIVE: To determine risk-reducing early salpingectomy and delayed oophorectomy (RRESDO) acceptability and effect of surgical prevention on menopausal sequelae/satisfaction/regret in women at increased ovarian cancer (OC) risk. DESIGN: Multicentre, cohort, questionnaire study (IRSCTN:12310993). SETTING: United Kingdom (UK). POPULATION: UK women without OC ≥18 years, at increased OC risk, with/without previous RRSO, ascertained through specialist familial cancer/genetic clinics and BRCA support groups. METHODS: Participants completed a 39-item questionnaire. Baseline characteristics were described using descriptive statistics. Logistic/linear regression models analysed the impact of variables on RRESDO acceptability and health outcomes. MAIN OUTCOMES: RRESDO acceptability, menopausal sequelae, satisfaction/regret. RESULTS: In all, 346 of 683 participants underwent risk-reducing salpingo-oophorectomy (RRSO). Of premenopausal women who had not undergone RRSO, 69.1% (181/262) found it acceptable to participate in a research study offering RRESDO. Premenopausal women concerned about sexual dysfunction were more likely to find RRESDO acceptable (odds ratio [OR] = 2.9, 95% CI 1.2-7.7, P = 0.025). Women experiencing sexual dysfunction after premenopausal RRSO were more likely to find RRESDO acceptable in retrospect (OR = 5.3, 95% CI 1.2-27.5, P

Published
2020

29. Unusual presentation of IgG4-related disease

Author

Martí Esteban I Fernández, Jordi Robert Olalla, and Jonathan Franco Vanegas

Subjects
medicine.medical_specialty, business.industry, media_common.quotation_subject, MEDLINE, General Medicine, medicine.disease, Presentation, Text mining, Rheumatology, Immunoglobulin G, medicine, Humans, IgG4-related disease, Immunoglobulin G4-Related Disease, Intensive care medicine, business, media_common
Published
2020

30. Atención integral del neonato con encefalopatía hipóxico-isquémica en España

Author

Arnaez, J., Herranz-Rubia, N., Garcia-Alix, A., Diez-Delgado, J., Benavente-Fernández, I., Tofé, I., Jerez, A.E., Hurtado, J.A., Ceballos, J.M., Millán, M.L., Esquivel, M.D., Ruiz, C., Baca, M., Tapia, E., Losada, M., Torres, E., Pavón, A., Jiménez, P.J., Jiménez, F., Ventura, M.P., Rite, S., González, T., Arias, R.P., Balliu, P.R., Lloreda-García, J.M., Alcaráz, J.L., Tapia, C., de la Morena, A., Centelles, I., Güemes, I., Estañ, J., Alberola, A., Aparici, S., López, R., Beceiro, J., García, B., Martínez, L., González, E., Arruza, L., Blanco, M.D., Moral, M.T., Arias, B., Mar, F., Jiménez, J., Romera, G., Cuñarro, A., Muñóz, C., Cabañas, F., Valverde, E., Montero, R., Tejedor, J.C., Santana, C., Reyes, B., Romero, S., Orizaola, A., Baquero, M., Hernández, D., Pantoja, A., Vega-del-Val, C., Castañón, L., Gutiérrez, E.P., Benito, M., Caserío, S., Arca, G., García, M.J., López-Vílchez, M.A., Castells, L., Domingo, M., Coroleu, W., Boix, H., Porta, R., García-Alix, A., Martínez-Nadal, S., Jiménez, E., Sole, E., Albújar, M., Fernández, E.M., Barrio, A.R., Piñán, E., Avila-Alvarez, A., Vázquez, M.E., Balado, N., Crespo, P.A., Couce, M.L., Concheiro-Guisán, A., Esteban, I., Lavilla, A., Alzina, V., Aguirre, A., Loureiro, B., Echániz, I., Elorza, M.D., Euba, A., and Grupo de Trabajo ESP-E, HI. Unidades de Neonatologia. Hospitales terciarios, España

Abstract

Introducción Apenas conocemos cómo es la asistencia de los recién nacidos (RN) con encefalopatía hipóxico-isquémica (EHI) en hipotermia terapéutica (HT), especialmente si existen protocolos asistenciales, la neuromonitorización que se realiza o cómo es la aproximación al pronóstico neurológico. Este conocimiento permite detectar e implementar áreas de mejora asistencial. Método Estudio transversal de los 57 hospitales españoles que realizaban HT en 2015, mediante cuestionario sobre: 1) la disponibilidad de protocolos y de recursos tecnológicos; 2) el uso de herramientas de neuromonitorización; 3) los conocimientos de los profesionales; 4) la información pronóstica que se da los padres, y 5) el informe al alta y del plan de seguimiento. Resultados El 95% utiliza enfriamiento corporal-total servocontrolado y dispone de protocolos específicos de actuación. El 70% utiliza sedación y el 68% deja al paciente a dieta absoluta. La monitorización con electroencefalografía integrada por amplitud se utiliza en más del 80% de los centros, aunque solo en el 50% la enfermera es capaz de interpretarlo. La saturación de oxígeno cerebral es escasamente monitorizada (16%). Entre los estudios diagnóstico-pronósticos, la neuroimagen es universal, pero los neurobiomarcadores apenas se utilizan (29%). Solo el 21% ofrece información pronóstica antes de las 72 h de vida; sin presencia de la enfermera en el 70%. El seguimiento lo realiza el neuropediatra (84%), con una duración desigual entre centros. Conclusiones La asistencia del RN con EHI en España es adecuada, con áreas de mejora en: neuromonitorización, sedación, marco temporal de la información pronóstica, trabajo en equipo y estandarización de la duración del seguimiento.

Published
2020

31. Anatomía comparada en cuatro helechos Cheilantoideos

Author

Dematteis, Bruno, Solís, Stella M., Yesilyurt, Jovita C., and Meza Torres, Esteban I.

Subjects
Adiantopsis, anatomía, Cheilanthes, Doryopteris, epidermis, mesóflo, Adiantopsis, anatomy, Cheilanthes, Doryopteris, epidermis, mesophyll
Abstract

Background and aims: Some species of Cheilanthoid ferns are characterized by show adaptations to xeric habitats. Furthermore, presents the peculiarity of the roll their blades under drought stress and when conditions are optimal they expand again. The aims of this work are provide morpho-anatomical information of the leaves and relate with the environmental conditions in which grow. M&M: The fronds' morpho-anatomy of four species (Adiantopsis radiata, Cheilanthes glauca, Doryopteris concolor and D. pentagona) were analyzed through light microscopy. Also, the stomatal density and stomatal index were obtained. Results: Homogenous mesophyll was observed in D. pentagona. Adiantopsis radiata, C. glauca and D. concolor showed dorsiventral heterogeneous mesophyll. All species studied showed hypostomatic leaf, with anomocytic stomata. The stomatal index observed was between 9.1% (A. radiata) and 14.1% (D. concolor), and the range of stomata density varied between 39.7 (D. pentagona) and 57.8 (D. concolor). Conclusions: The mesophyll observed in A. radiata, and D. pentagona responds to a mesophytic environment. Doryopteris concolor was reported as a facultative epiphyte, and its dorsiventral heterogeneous mesophyll would be an advantage in this habitat. Cheilanthes glauca has xeromorphic and mesomorphic features, probably resulting from water availability during the different seasons. We porpose as hypothesis that the thickening of the anticlinal walls of epidermal cells could be involved in the leaf movements. Introducción y objetivos: Algunas especies de helechos cheilanthoideos son caracterizados por presentar adaptaciones a hábitats xéricos. Además, presentan la particularidad de enrollar sus láminas frente a condiciones de stress hídrico. Sin embargo, al retornar las condiciones ambientales óptimas las láminas se vuelven a expandir. El objetivo de este trabajo es proporcionar información morfo-anatómica de las frondes y asociar estructuras anatómicas a estos movimientos foliares. M&M: Se estudiaron mediante microscopía óptica y electrónica de barrido la morfo-anatomía de las frondes de cuatro especies: Adiantopsis radiata, Cheilanthes glauca, Doryopteris concolor y D. pentagona. Además, se analizó la densidad de los estomas y se calculó el índice estomático. Resultados: Se observó mesóflo homogéneo en D. pentagona. Adiantopsis radiata, C. glauca y D. concolor presentaron mesóflo heterogéneo dorsiventral. Todas las especies mostraron hojas hipoestómaticas y estomas de tipo anomocítico. El índice estomático osciló entre 9,1% (A. radiata) y 14,1% (D. concolor) y el rango de densidad de los estomas fue de 39,7 (D. pentagona) y 57,8 (D. concolor). Conclusiones: El mesóflo observado en A. radiata y D. pentagona refeja una especialización mesofítica. El mesóflo heterogéneo dorsiventral de D. concolor podría ser una ventaja para su hábito epifítico facultativo. Cheilanthes glauca tiene características xeromorfas y mesomorfas, probablemente como resultado de la disponibilidad de agua en el ambiente durante las diferentes estaciones. Se propone como hipótesis que el engrosamiento de las paredes anticlinales de las células epidérmicas podría estar involucrados en los movimientos de las láminas.

Published
2019

33. Breaking the no cross-coupling condition of polarization-maintaining optical fibers

Author

Jesús I. Espinoza-Blanco, J. J. Sánchez-Mondragón, Nestor Lozano-Crisostomo, Julio C. Garcia-Melgarejo, and Esteban I. García-Villanueva

Subjects
Materials science, Optical fiber, Orthogonal polarization spectral imaging, Physics::Optics, Optical power, 02 engineering and technology, 021001 nanoscience & nanotechnology, Polarization (waves), 01 natural sciences, Molecular physics, law.invention, 010309 optics, law, 0103 physical sciences, 0210 nano-technology
Abstract

We show how the condition of no cross-coupling of optical power between the two orthogonal polarization modes in polarization-maintaining optical fibers is broken.

Published
2019
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34. Low-dose budesonide/formoterol counteracts airway inflammation and improves lung function in COPD

Author

Hakim, A, Khan, Y, Esteban, I, Meah, S, Miller-Larsson, A, Barnes, PJ, and Usmani, OS

Subjects
EXACERBATIONS, Science & Technology, Critical Care Medicine, General & Internal Medicine, Respiratory System, Life Sciences & Biomedicine, hormones, hormone substitutes, and hormone antagonists, 11 Medical and Health Sciences
Abstract

The latest Global Initiative for Chronic Obstructive Lung Disease (GOLD) document recommends new treatment algorithms, with inhaled corticosteroids (ICS) use only in moderate-to-severely symptomatic COPD patients with repeated exacerbations, where the emphasis is to review ICS use and to reduce ICS dosing (1). Indeed, safety concerns of pneumonia (2) with high-dose ICS has further concerted focus upon using appropriate doses of ICS. It is well-established that ICS in combination with long-acting β2-adrenoceptor agonist (LABA) can decrease exacerbations, improve symptoms and increase quality of life in patients with COPD (3-4), but nonetheless, the rationale to consider step-down of ICS is supported by several clinical studies (5). The Withdrawal of Inhaled Steroids during Optimized Bronchodilator Management (WISDOM) trial studied severe COPD patients on therapy with ICS, LAMA and LABA, where stepwise withdrawal of ICS did not lead to an increase in exacerbations compared to continued ICS use (6). Determining the optimal dose of ICS and LABA combination therapy is of great biological and clinical importance in order to address safety concerns associated with high-dose ICS use. There is in vitro evidence to support the clinical practice of using low-dose ICS. Low-dose ICS in combination with LABA enhances corticosteroid function by enhancing glucocorticoid receptor (GR) activity (7) and suppresses the release of inflammatory mediators (8). However, it is unknown whether this observation of enhanced corticosteroid function with low-dose ICS/LABA has a direct effect on airways inflammation and lung function. Our study investigated the cellular function that may be relevant and underpin the clinical approach to lowering the dose of ICS therapy in COPD patients. We compared the single administration of low-dose ICS/LABA combination to high-dose ICS alone and high-dose ICS/LABA on GR activation, molecular markers of AJRCCM as airway inflammation and lung function in COPD patients 2 hours post-treatment. Some of the results of these studies have been previously reported in the form of an abstract (9).

Published
2018

35. Direct Model Predictive Control without Steady-State Error proposed for a Cascade H-Bridge Multilevel Inverter to operate in a Microgrid

Author

Richard Duarte, Carlos R. Baier, Roberto O. Ramirez, Esteban I. Marciel, Carlos Restrepo, Eduardo Espinosa, and Pedro Melin

Subjects
Computer science, 020208 electrical & electronic engineering, 02 engineering and technology, Converters, H bridge, Power (physics), Model predictive control, Sampling (signal processing), Control theory, Cascade, 0202 electrical engineering, electronic engineering, information engineering, Inverter, 020201 artificial intelligence & image processing, Microgrid
Abstract

Cascade H-bridge multilevel (CHB-ML) inverters are an excellent alternative to supply power to the ac micro-grids since they have high reliability and achieve an acceptable quality of voltage at their output terminals. On the other hand, the standard direct model predictive control (MPC) scheme is a very intuitive strategy to control this type of converters, but in general, has a steady-state error when operates with low sampling frequencies and/or if the parameters of the predictive model are different in the real system. In this paper, a CHB-ML inverter that injects power to a micro-grid using a new improved direct MPC scheme is proposed. The proposed strategy eliminates the steady-state error in the MPC operating with low sampling frequencies, also maintaining a correct operation when occurring a change in some parameter of the system. Simulated results will demonstrate the feasibility of the proposal.

Published
2018
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36. EL GÉNERO PECLUMA (POLYPODIACEAE) EN ARGENTINA

Author

Olga G. Martínez, Francine C. Assis, Esteban I. Meza Torres, Daniel A. Cacharani, and Dalma G. Jaimez

Subjects
lcsh:Biology (General), lcsh:Botany, lcsh:Q, Plant Science, lcsh:Science, lcsh:QH301-705.5, lcsh:QK1-989
Abstract

El género Pecluma en Argentina está representado por 11 especies, la mayoría son epífitas en la región norte. Pecluma plumula se registra por primera vez para el noroeste argentino. Se presentan descripciones, sinonimias, claves para determinar las especies, ejemplares examinados, ilustraciones y mapas de distribución para cada especie. Además, se brindan comentarios taxonómicos y nomenclatura - les en aquellos casos en los se resuelven cuestiones de tipificación.

Published
2016

37. Care of the newborn with perinatal asphyxia candidate for therapeutic hypothermia during the first six hours of life in Spain

Author

Arnaez J, Garcia-Alix A, Calvo S, Lubian-Lopez S, Diez-Delgado J, Benavente I, Tofe I, Jerez A, Hurtado J, Ceballos J, Millan M, Esquivel M, Ruiz C, Baca M, Tapia E, Losada M, Torres E, Pavon A, Jimenez P, Jimenez F, Ventura M, Rite S, Gonzalez T, Arias R, Balliu P, Lloreda-Garcia J, Alcaraz J, Tapia C, de la Morena A, Centelles I, Guemes I, Estan J, Alberola A, Aparici S, Lopez R, Beceiro J, Garcia B, Martinez L, Gonzalez E, Arruza L, Blanco M, Moral M, Arias B, Mar F, Jimenez J, Romera G, Cunarro A, Munoz C, Cabanas F, Valverde E, Montero R, Tejedor J, Santana C, Reyes B, Romero S, Orizaola A, Baquero M, Hernandez D, Pantoja A, Vega C, Castanon L, Gutierrez E, Benito M, Caserio S, Arca G, Garcia M, Lopez-Vilchez M, Castells L, Domingo M, Coroleu W, Boix H, Porta R, Martinez-Nadal S, Jimenez E, Sole E, Albujar M, Fernandez E, Barrio A, Pinan E, Avila-Alvarez A, Vazquez M, Balado N, Crespo P, Couce M, Concheiro-Guisan A, Esteban I, Lavilla A, Alzina V, Aguirre A, Loureiro B, Echaniz I, Elorza M, Euba A, and Grp Trabajo ESP-EHI

Published
2018

38. Cálculo del índice de la oscilación del Mediterráneo Occidental con técnicas de análisis multivariante

Author

Arbiol Roca, Laia, López Bustins, Joan Albert, Esteban i Vea, Pere, and Martín-Vide, Javier

Subjects
WeMO, COST733class, Teleconexión, Precipitation, Clasificación sinóptica, Teleconnection, Variability, Reanálisis, Precipitación
Abstract

Ponencia presentada en: XI Congreso de la Asociación Española de Climatología celebrado en Cartagena entre el 17 y el 19 de octubre de 2018. [ES]El análisis espacial de las circulaciones asociadas a los patrones de teleconexión es esencial para el conocimiento de la dinámica atmosférica. La Oscilación del Mediterráneo Occidental (WeMO) es un patrón que explica una parte sustancial de la variabilidad pluviométrica de distintas regiones mediterráneas. En este trabajo se plantea realizar una clasificación de tipos de circulación atmosférica a partir del método PXE (Principal Extreme Scores) desarrollado en el proyecto europeo COST733, y con datos de reanálisis ERA-Interim para el período 1979-2017. El método de clasificación utilizado, basado en el análisis por componentes principales, permite una buena discriminación de las fases positiva y negativa de la WeMO. Se ha trabajado con una matriz espacial centrada sobre el sector suroeste de Europa y distintas escalas. La ventana sinóptica en la que se ha observado con una mayor definición la WeMO es 30ºN 60ºN y 15ºO 20ºE. Las medias pluviométricas asociadas a los días clasificados en las fases negativas de la WeMO delimitan bien el sur del golfo de Valencia. [EN]The spatial analysis of the circulations associated with the teleconnection patterns is essential for the knowledge of atmospheric dynamics. The Oscillation of the Western Mediterranean (WeMO) is a pattern that explains part of the rainfall variability in different Mediterranean regions. In this work, we propose to perform a classification of types of atmospheric circulation from the PXE (Principal Extreme Scores) method developed in the European project COST733 join with ERA-Interim reanalysis data for the 1979-2017 period. The classification method used, based on the principal component analysis, allows a good discrimination of the positive and negative phases of the WeMO.We have worked with a spatial matrix, centered on the southwest sector of Europe, at several spatial scales. The synoptic window 30ºN 60ºN and 15ºW 20ºE showed the best WeMO spatial configuration. The rainfall means of those days classified in WeMO negative phases have got high values in the southern region of the gulf of Valencia. Este trabajo ha sido financiado por los proyectos WEMOTOR (CSO2014-55799-C2-1-R, 2015-2017) y CLICES (CGL2017-83866-C3-2-R, 2018-2020) del Ministerio de Economía y Competitividad, y ha contado con el apoyo del Grup de Climatologia (UB) (2017SGR1362, Generalitat de Catalunya).

Published
2018

39. Compartir ideas. La Universidad va al Instituto: un proyecto de aprendizaje- servicio transversal de la Universidad de Barcelona

Author

Amat, Concepció, Anderson, Miriam, Arias Sampériz, Bárbara, Asensio, José Antonio, 1957, Ballesteros Pérez, Esperanza, Boix, Emili, 1956, Bondia, David, Buenaventura Rubio, Maria Antonia, Bueno i Torrens, David, 1965, Carrera i Sabaté, Josefina, Cases Rodrigo, Irene, Coll, Tónia, 1965, Collado Sevilla, Antonia, Condom Bosch, Josep Lluís, Cortès Izquierdo, Ferran, Costa Cuberta, Mercè, Cuffí i Chéliz, Maria Laura, Delás, Jordi, Domingo Clua, Josep M., Escobedo, Anna, Escofet Roig, Anna, Esparza Pagès, Mireia, Esteban i Torné, Maria Esther, Fatjó-Vilas Mestre, Mar, Fernández Cuevas, Ana Belén, Fontiveros Sánchez, Manuel, García García, Ascensión, Giménez Merino, Antonio, Goula, Marta, Grasso, Guillermo, Grau, Eulàlia (Grau i Costa), Illán Villanueva, Montserrat, Lama López, María Xesús, Lecuona Ramírez, Itziar de, López, Marta, Madrid, Antonio, 1968, March Pujol, Marian, Martín, Xus, Martínez, Miquel, and Massip i Bonet, M. Àngels, 1957

Subjects
Social responsability of business, Responsabilitat social de l'empresa, Aprenentatge servei, Service learning
Abstract

Compartir ideas. La universidad va al instituto es un proyecto de aprendizaje servicio transversal de la Universidad de Barcelona. Este representa una propuesta de aprendizaje servicio que bajo una estructura común permite la participación de estudiantes y profesorado de distintas disciplinas en un mismo proyecto. El aprendizaje servicio (ApS) es una propuesta formativa que permite el desarrollo de diferentes tipos de aprendizajes a partir de la implicación en necesidades sociales reales con la intención de transformarlas (Tapia, 2001; Martínez, 2008; Puig, 2009). En este tipo de proyectos están presentes simultáneamente la intencionalidad pedagógica y la intencionalidad solidaria. Se pueden definir como experiencias educativas solidarias protagonizadas por estudiantes, que tienen como objetivo atender a una necesidad de los destinatarios a la vez que planificar y mejorar la calidad de los aprendizajes (Tapia, 2006).

Published
2018

40. Helechos y licofitos de la Reserva Natural Educativa Colonia Benítez (Chaco, Argentina)

Author

Bruno Dematteis and Esteban I. Meza Torres

Subjects
Monilophyta, Colonia Benítez (Chaco), Inventario florístico, Conservation, Plant Science, Microgramma, Helechos, Biochemistry, Genetics and Molecular Biology (miscellaneous), Genus, lcsh:Botany, Botany, Genetics, Área protegida, Ecology, Evolution, Behavior and Systematics, Pityrogramma, Diversidad, Diversity, Monilófitas, biology, Azolla cristata, Botánica, Floristic inventory, biology.organism_classification, Azolla, Protected area, Pleopeltis, lcsh:QK1-989, Geography, Herbarium, Conservación, Epiphyte, Cartography
Abstract

Fil: Dematteis, Bruno. Universidad Nacional del Nordeste. Facultad de Ciencias Agrarias; Argentina. Fil: Dematteis, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Botánica del Nordeste; Argentina. Fil: Meza Torres, Esteban I. Universidad Nacional del Nordeste. Facultad de Ciencias Agrarias; Argentina. Fil: Meza Torres, Esteban I. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. La Reserva Natural Educativa Colonia Benítez cuenta con una superficie aproximada de ocho ha, está ubicada en el departamento Primero de Mayo, en la provincia del Chaco, Argentina. Desde el punto de vista fitogeográfico, esta área protegida se localiza dentro del Distrito Chaqueño Oriental de la Provincia Chaqueña. Como objetivos de este trabajo se planteó realizar un inventario de helechos y licofitos y una clave para el reconocimiento de los taxa que crecen en esta reserva. A tal fin, se examinaron las colecciones depositadas en CTES, y se realizaron nuevas recolecciones de especímenes. Se registraron 12 géneros con un total de 17 especies, siendo Doryopteris el género mejor representado con tres especies: D. concolor, D. lorentzii y D. pentagona. El género Adiantopsis presentó dos especies (A. chlorophylla y A. tweediana), al igual que Anemia con (A. simplicior y A. tomentosa var. anthriscifolia) y Pteris (Pteris denticulata var. tristicula y Pteris vittata). Los demás géneros presentaron sólo una especie: Adiantum lorentzii, Anogramma chaerophylla, Azolla cristata, Hemionitis tomentosa, Microgramma vaccinifolia, Pityrogramma calomelanos var. calomelanos, Pleopeltis minima y Selaginella sellowii. El hábito terrícola fue el mejor representado con 12 especies, de las cuales una de ellas es rupícola y otras tres se pueden comportar como epífitos facultativos, en tanto que los estrictamente epífitos fueron representados por sólo dos especies. Azolla cristata fue la única especie acuática presente. Se presentan observaciones ecológicas y un análisis biogeográfico de las especies registradas. The Educational Nature Reserve of Colonia Benítez comprises approximately 8 ha and is located in the department of Primero de Mayo of the Chaco Province, Argentina. This protected area occurs within the Chaco Oriental District of the Chaco phytogeographic province. The main aims of the present study were to realize an inventory of ferns and lycophytes and provide a key to identify all the taxa present in the reserve. We analyzed the collections deposited at the herbarium CTES and collected new specimens. A total of 12 genera and 17 species were recorded. Doryopterisis the best represented genus with three species: D. concolor, D. lorentzii and D. pentagona. Three genera included two species: Adiantopsis(Ad. chlorophylla and Ad. tweediana), Anemia(An. simplicior and An. tomentosavar. anthriscifolia), and Pteris(P. denticulatavar. tristiculaand P. vittata). The remaining genera included only one species: Adiantum lorentzii, Anogramma chaerophylla, Azolla cristata, Hemionitis tomentosa, Microgramma vaccinifolia, Pityrogramma calomelanosvar. calomelanos, Pleopeltis minima, and Selaginella sellowii. The terrestrial habit was the best represented with 12 species, one of which was rupicolous and other three were facultative or accidental epiphytes. Only two taxa were strict epiphytes. Azolla cristatawas the only aquatic species recorded in the area. Ecological observations and biogeographical analyses are provided for the recorded species.

Published
2015

41. Distribution of Ophioglossum reticulatum L. in South America. A case of long-distance jump dispersal?

Author

Ana G. Ulke, Esteban I. Meza Torres, Bibiana Cerne, and Marta A. Morbelli

Subjects
Spores, Monsoon, Atmospheric Science, Atmospheric circulation, Health, Toxicology and Mutagenesis, BOTANICA, Distribution (economics), Recurrentmigration, Ciencias Biológicas, Troposphere, LOW-LEVEL JET, Ciencias Naturales, RECURRENT MIGRATION, Ciencias de las Plantas, Botánica, Air Movements, Ecology, business.industry, JUMP DISPERSAL, FERNS, Temperature, Low-level jet, Humidity, Recurrent migration, Reproductive isolation, Models, Theoretical, South America, MONSOON, DISSEMINULES, Jump dispersal, Tracheophyta, Taxon, Geography, Climatology, Africa, Ferns, Jump, Biological dispersal, Disseminules, business, CIENCIAS NATURALES Y EXACTAS
Abstract

The objective of this exploratory work is to test the hypothesis that South American populations of Ophioglossum reticulatum L. derive from Africa. Spores cross the Atlantic transported by wind and arrive in South America in recurrent migration. Three-dimensional (backward and forward) trajectories of spores between Africa and South America were calculated using the Hybrid Single Particle Lagrangian Integrated Trajectory Model (HYSPLIT4). The model showed possible backward trajectories in the low troposphere arriving in South America with probable origin in Northwestern Africa. The results support the hypothesis of long-distance dispersal of the studied species. Including vertical motion in the model runs allowed obtaining valuable and novel information about the migration routes. The trade winds combined with the South American monsoon could be a dispersal vehicle for the disseminules from Northwestern Africa to the eastern slopes of the Andes. As the monsoon is a periodic regional atmospheric circulation pattern, transcontinental migration can be assumed to be a recurring phenomenon that provides genetic exchange and prevents speciation by reproductive isolation. Modelled forward trajectories connect the neotropics with Africa-Madagascar, but they seem to be less effective due to their travelling altitudes. This hypothesis might explain the absence of infraspecific taxa restricted to different geographic locations., Facultad de Ciencias Naturales y Museo

Published
2014
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42. Toxic Megacolon From an Unheard Tropical Parasite

Author

Esteban I. Rodriguez-Martino, Ivonne Figueroa-Rivera, Jose J. Gutierrez-Nuñez, Rodolfo Estremera-Marcial, Jose Martin-Ortiz, Mariela Navarro-Torres, Javier A. Cerra-Franco, and Carlos Fernandez-Cruz

Subjects
Toxic megacolon, Hepatology, business.industry, Gastroenterology, Parasite hosting, Medicine, business, medicine.disease, Microbiology
Published
2018
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43. Análisis biogeográfico y clave de géneros de los helechos y licofitos del Parque Nacional Mburucuyá, Corrientes, Argentina

Author

Esteban I Meza-Torres, María Silvia Ferrucci, and Elías Ramón de la Sota

Subjects
Monilophytes, National park, Protected area, Archaeology, Floristic diversity, Pteridophytes, purl.org/becyt/ford/1 [https], Ciencias Biológicas, Geography, Ciencias Naturales, Key (lock), purl.org/becyt/ford/1.6 [https], Floristic Diversity, General Agricultural and Biological Sciences, Protected Area, Ciencias de las Plantas, Botánica, CIENCIAS NATURALES Y EXACTAS, General Environmental Science
Abstract

The diversity of ferns and lycophytes of Corrientes province, Argentina is not well understood. Our field work in the Mburucuyá National Park in Corrientes province as well as a literature review fi nds 29 genera and 48 infrageneric taxa of ferns and lycophytes for this Park. A comparison of the Park's species diversity with other protected areas in northeastern Argentina using Jaccard's similarity coeffi cient and the infrageneric taxa biodiversity index proposed by Squeo et al. (1998) are analized. A key to the Park's ferns and lycophytes genera is provided., El Parque Nacional Mburucuyá, cuenta con una superficie de 176.80 km2, se encuentra en la provincia de Corrientes, Argentina, dentro de una región ecotonal entre los dominios Chaqueños y Amazónicos. En esta área se registraron 29 géneros y 48 taxones infragenéricos de helechos y liocófi tos fueron registrados. Las especies registradas son comparadas con las áreas protegidas ya estudiadas del noreste de Argentina utilizando el coeficiente de similitud de Jaccard y el índice de biodiversidad de Squeo et al. (1998) a nivel infragenérico. En este trabajo se proporciona una clave para diferenciar los géneros presentes en el Parque., Facultad de Ciencias Naturales y Museo

Published
2013
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44. Ezetimibe added to statin therapy after acute coronary syndromes

Author

Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, Califf, Musliner T, Robert M., Tershakovec, A, Gurfinkel, E, Aylward, P, Tonkin, A, Maurer, G, Van de Werf, F, Nicolau, Jc, Theroux, P, Genest, J, Armstrong, P, Corbalan, R, Isaza, D, Spinar, J, Grande, P, Voitk, J, Kesaniemi, A, Bassand, Jp, Farnier, M, Darius, H, Keltai, M, Mathur, A, Mittal, S, Reddy, K, Lewis, B, De Ferrari GM, Ophuis, To, Jukema, J, White, H, Pedersen, T, Britto, F, Ruzyllo, W, Carrageta, M, Duris, T, Dalby, A, Seung, Kb, Lopez-Sendon, J, Dellborg, M, Mach, F, Guneri, S, Parkhomenko, A, Brady, A, Cannon, C, Blazing, M, Ballantyne, C, de Lemos, J, Kleiman, N, Mcguire, Dk, Centeno, E, Casalins, M, Cartasegna, L, Beltrano, Mc, Guerrero, R, Fanuele, M, Berra, F, Egido, J, Colombo, H, Dellatorre, M, Terns, P, Blumberg, E, Reges, P, Azize, G, Ramos, H, Fernandez, R, Carlessi, C, Milesi, R, Schmuck, R, Duronto, E, Procopio, G, Carlevaro, O, Maffeo, H, Beloscar, J, Viso, M, Hominal, M, Castoldi, M, Bluguermann, J, Mauro, D, Macin, S, Cocco, N, Ruiz, N, Ricart, J, Lozada, A, Nani, S, Turri, D, Fernandez, H, Caruso, O, Zarandon, R, Bono, J, Arias, V, Allall, O, Marino, J, Cusimano, S, Schygiel, P, Buzetti, C, Penaloza, N, Berli, M, Worthley, S, Roach, A, Chew, D, Wright, T, Leitch, J, Hicks, E, Rankin, J, Venn-Edmonds, C, Lehman, R, Morrison, H, Shaw, J, Mak, V, Hii, C, Smith, K, Cross, D, Lilwall, L, Nelson, G, Loxton, A, Horowitz, J, Rose, J, Steinwender, C, Leisch, F, Kammler, J, Brussee, H, Zweiker, R, Niederl, E, Weihs, W, Giorgio, G, Lang, I, Drexel, H, Zanolin, D, Hoppe, U, Atzenhofer-Baumgartner, K, Pichler, M, Hainzer, D, Eber, B, Pichler, F, Foeger, B, Wechselberger, T, Mayr, H, Hofer, J, Stockenhuber, F, Warlits, B, Huber, K, Egger, F, Weidinger, F, Ziegler, B, Jirak, P, Metzler, B, Pachinger, O, Wanitschek, M, Auer, J, Grabscheit, G, Podczeck-Schweighofer, A, Priesnitz, T, Frank, H, El Allaf, D, Marechal, P, Roosen, J, Joly, E, Lefebvre, P, Arend, C, Sinnaeve, P, De Velder, L, Hellemans, S, Vanhauwaert, B, Van Dorpe, A, Heyse, A, Vantomme, C, Striekwold, H, Van Den Broeck, D, Lancellotti, P, Schoors, D, Lemoine, I, Taeymans, Y, De Wolf, L, Brike, C, Vercauteren, S, Tahon, S, Vervoort, G, Mestdagh, I, Pirenne, B, Cardinal, F, Lips, S, Dujardin, K, Debrouwer, K, Dhooghe, G, Holvoet, G, van de Borne, P, Renard, M, De Clippel, M, Lesseliers, H, Van Miert, N, Saraiva, J, Vicente, C, Rossi, P, Dos Santos LB, Duda, N, Tognon, Ap, Serrano, C, Gomes, Fl, Manenti, Er, Silveira, Ds, Maia, L, Mouco, Om, Paiva, M, Antonangelo, A, de Souza, J, Lino, Ea, Leães, P, Blacher, Mg, Kormann, A, Ultramari, Ft, Dutra, O, Mendelski, Am, Morgado, S, Ardito, W, Greque, G, Ardito, Rv, Pimentel Filho, P, Zucchetti, C, Alves, A, Seabra, Am, Mattos, M, Miranda, Lf, Silva, D, Uehara, Rm, Marin Neto, J, Schmidt, A, Braga, J, Rodrigues, A, Abrantes, J, Pinheiro, L, Bodanese, L, Magedanz, Éh, Piegas, L, Dos Santos ES, Wainstein, M, Ribeiro, J, Stein, R, Marino, R, Machado, Vm, Moraes Junior, J, Guimarães, S, da Costa FA, Ferraz, Rf, Albuquerque, D, Rocha, Rm, de Carvalho Moreira, R, Dohmann, H, Costantini, C, Tarastchuk, Jc, Coelho, O, Cirillo, W, Sousa, A, Almeira, As, Stefanini, E, Silva, F, Teixeira, M, da Cunha, C, Précoma, D, Facchi, Tl, Rupka, D, Thiessen, S, Warnica, J, Smith, B, Della Siega, A, Klinke, P, Nelson, S, Dion, D, Gilbert, N, Hui, W, Kvill, L, Sussex, B, Luther, A, Dupuis, R, Ouimet, F, Pandey, A, Clarus, S, Senaratne, M, Ferdinandis, H, Mukherjee, A, Bozek, B, Vizel, S, Markov, G, Zimmermann, R, Stephens, W, Tremblay, B, Wong, G, Uchida, N, Brossoit, R, Peck, C, Van Kieu, C, Forgione, M, Bata, I, Cossett, J, Kostuk, W, Arnold, M, Bone, C, Grondin, F, Bilodeau, N, Gosselin, G, David, M, Giannoccaro, J, Beresford, P, Polasek, P, Roberts, P, Doucet, M, Beaudry, M, Cheung, S, Cleveland, T, Bhargava, R, Mccallum, A, Ma, P, Morrissette, J, Cleveland, D, Chadwyn, D, Nigro, F, Weeks, A, Cryderman, C, Leader, R, Houde, G, Rousseau, S, Pearce, M, Radyk, M, Lonn, E, Magi, A, Lefkowitz, C, Sandrin, F, Coffin, N, Lubelsky, B, Coldwell, J, Habot, J, Mcpherson, C, De Larochelliere, R, Roy, M, Haichin, R, Barber, C, Bhesania, T, Kitagawa, H, To, T, Donnelly, B, Tymchak, W, Harris, L, Kouz, S, Huynh, T, St Jacques, B, Lamy, A, Rizzo, A, Stein, J, Childs, C, Wong, B, Poirier, R, Gupta, M, Dela Cruz, C, Constance, C, Gauthier, M, Ervin, F, Ouellette, M, Kokis, A, Lemay, C, Kwok, K, Leung, C, Lee, D, Nesmith, J, Renton, J, Syan, G, Turek, M, Hogan, D, Griffin, P, Lipson, A, Winestock, J, Abramson, B, Fogel, A, Gagne, C, Bergeron, J, Clarke, A, Slipp, S, Darcel, I, Carling-Chambers, L, Kannampuzha, P, Pallie, S, Krekorian, S, Vertes, G, Roth, S, Lai, K, Heath, J, Perez, L, Arriagada, G, Castro, P, Villa, F, Rodríguez, M, Ramos, G, Baraona, F, Núñez, A, García, M, Jofre, C, Silva, P, Lamich, R, Yovaniniz, P, Escobar, E, Dussaubat, A, Segura, E, Ramirez, M, Lapostol, C, Palma, A, Encina, L, Zapata, M, Baeza, N, Varela, P, Pérez, L, Jaramillo, C, Ruiz, S, Sanchez, G, Perdomo, I, Manzur, F, Cohen, Le, Velasquez, J, Arana, C, Alvarez, Y, Triana, M, Balaguera, J, de Salazar, D, Rendon, N, Botero, R, Ruiz, A, Saaibi, J, Medina, J, Jaramillo, M, Calderón, Mj, Delgado, J, Bohorquez, R, Medina, Mf, Herrera, M, Rosales, D, Mendoza, F, Martinez, S, Ternera, A, Castro, R, Baiz, A, Martinez, M, Orozco, A, Suarez, M, Fonseca, Y, Beltran, R, Cepeda, M, Jaramillo, N, Valenzuela, C, Gutierrez, M, Sanchez, A, Vitovec, J, Hlinomaz, O, Poloczek, M, Mayer, O, Veselka, J, Vejvoda, J, Soucek, M, Spac, J, Novobilsky, K, Srp, V, Francek, L, Branny, M, Sknouril, L, Motovska, Z, Rohac, F, Stankova, A, Fiala, T, Holub, M, Zeman, K, Pohludkova, L, Pospisilova, E, Tuma, P, Cihalik, C, Oral, I, Podpera, I, Stepanovova, R, Uricar, M, Solar, M, Pelouch, R, Porzer, M, Grussmannova, K, Stipal, R, Reichert, P, Hradec, J, Kral, J, Sejkova, B, Janek, B, Pitha, J, Linhart, A, Polacek, P, Koeber, L, Clemmensen, P, Hebin, Ch, Schmidt, E, Pedersen, Ms, Roseva-Nielsen, N, Kristensen, K, Bang-Hansen, T, Jensen, J, Laage-Petersen, J, Nielsen, H, Stokholm, E, Thayssen, P, Cappelen, H, Jensen, T, Winther-Friis, B, Klausen, I, Hedegaard, B, May, O, Andersen, M, Bottzauw, J, Lush, A, Markenvard, J, Vestager, Km, Bronnum-Schou, J, Hempel, H, Petersen, J, Nielsen, Aj, Thomsen, K, Nielsen, T, Nygaard, A, Sykulski, R, Jensen, Bs, Ralfkiaer, N, Gottschalck, H, Rasmussen, S, Pedersen, Lr, Dodt, K, Skovsbøl, M, Andersen, O, Tuxen, C, Meier, Aw, Kristensen, T, Rasmussen, O, Lopez, J, Salazar, D, Sanchez, L, Rosero, F, Penaherrera, E, Duarte, Yc, Marmol, R, Andrade, G, Guzman, E, Morillo, A, Aug, L, Loogna, I, Laanmets, P, Mustonen, J, Mäntylä, P, Kesäniemi, A, Ukkola, O, Kervinen, H, Juhela, S, Juvonen, J, Toppinen, A, Jarvenpaa, J, Syvanne, M, Svahn, T, Voutilainen, S, Huotari, A, Nikkila, M, Raiskinmäki, S, Kotila, M, Rajala, A, Laukkanen, J, Hiltunen, P, Melin, J, Nyman, K, Luukkonen, J, Kosonen, P, Huttunen, M, Seppänen, V, Airaksinen, J, Juonala, M, Lehto, S, Savolainen, K, Halkosaari, M, Sia, J, Palomaki, A, Luoma, J, Utriainen, S, Valpas, S, Tiensuu, T, Lilleberg, J, Kainulainen, R, Schiele, F, Bassand, J, Meneveau, N, Galinier, M, Jean, M, Martelet, M, Mouallem, J, Elbaz, M, Puel, J, Carrié, D, Coisne, D, Varroud-Vial, N, Jaboureck, O, Dujardin, J, Leroy, F, Mansourati, J, Funck, F, Jourdain, P, Guillard, N, Coviaux, F, Gay, A, Dourmap-Collas, C, Froger-Bompas, C, Paillard, F, Tricot, O, Maquin-Mavier, I, Dubois-Rande, Jl, Pongas, D, Paris, Ap, Delahaye, F, Ovize, M, Benyahya, L, Bonnet, J, Belle, L, Mangin, L, Lafitte, B, Zemour, G, Doux, N, Agraou, B, El Mansour, N, Traisnel, G, El Jarroudi, M, Ohlmann, P, Diadema, B, Escande, M, Legros, G, Demarcq, Jm, Haftel, Y, Alsagheer, S, Dambrine, P, Cottin, Y, Ghostine, S, Caussin, C, Gacem, A, Bouvier, Jm, Poulard, J, Davy, J, Furber, A, Prunier, F, Muenzel, T, Genth-Zotz, S, Appel, K, Kretzschmar, D, Ferrari, M, Terres, W, Uher, T, Schulze, H, Ochs, H, Morbach, S, Duengen, H, Gross, M, Oezcelik, C, Tahirovic, E, Heuer, H, Laschewski, B, Kadel, C, Rahn, G, Steiner, S, Kreuzer, J, Tsoy, I, Zeiher, A, Muegge, A, Hanefeld, C, Boehm, S, Boudriot, E, Hodenberg, E, Lippe, B, Hausdorf, C, Sydow, K, Baldus, S, Schlesner, C, Tiroch, K, Haltern, G, Guelker, H, Wilhelm, J, Dietz, S, Ebelt, H, Buerke, M, Rupprecht, H, Rittgen, J, Schaeufele, T, Meinhardt, G, Schieber, M, Honold, M, Sieprath, S, Nienaber, C, Hacker, J, Butter, C, Lapp, H, Hirn, S, Pauschinger, M, Zahn, R, Scheffler, U, Schaefer, A, Schieffer, B, Tebbe, U, Kriete, M, Mudra, H, Raeder, T, Braun, P, Zeymer, U, Kouraki, K, Reppel, M, Schunkert, H, Weil, J, Olbrich, H, Schwaiger, P, Mueller, O, Blessing, E, Buss, I, Bohlscheid, V, Kaddatz, J, Skowasch, D, Nickenig, G, Twelker, K, Osterhues, H, Varghese, T, Burghard, S, Kaeaeb, S, Klauss, V, Sohn, Hy, Hauptmann, K, Schulze, M, Gall, K, Felix, S, Doerr, M, Mante, J, Gulba, D, Freick, M, Werner, G, Kleinertz, K, Hobbach, Hp, Halbach, M, Mueller-Ehmsen, J, Mueller, Me, Mitrovic, V, Peil, A, Laufs, U, vom Dahl, J, Baumanns, S, Scholtz, W, Wiemer, M, Haude, M, Van de Loo, A, Pistorius, K, Schaefer, J, Schwinger, R, Goeing, O, Jung, W, Birkemeyer, R, Lee, W, Kong, S, Yu, C, Chui, K, Merkely, B, Szelényi, Z, Polgár, P, Svab, S, Herczeg, B, Bajcsi, É, Vértes, A, Davidovits, S, Nagy, A, Király, C, Lupkovics, G, Kenéz, A, Poór, F, Takács, J, Kirschner, R, Simonyi, G, Koncz, J, Édes, I, Gergely, S, Katona, A, Nagy, E, Kovács, Z, Gyetvai, I, Salamon, C, Kolman, É, Sitkei, É, Csapó, K, Molnar, K, Mező, I, Sereg, M, Reddy, P, Manjunath, C, Narayanappa, S, Kumar, S, Sinha, N, Kapoor, A, Christopher, J, Reddy, G, Rani, M, Oomman, A, Ramamurthee, K, Kumar, N, Pasha, Ss, Rao, C, Murty, Gs, Chopra, A, Kapila, D, Bali, H, Chattree, K, Hasan, O, Suryaprakash, G, Rao, D, Babu, R, Bhargavi, M, Naik, S, Khan, S, Chopra, V, Sapra, R, Kaul, U, Ghose, T, Menon, R, Battikadi, S, Mullasari, A, Subban, Vk, Dani, S, Iby, M, Chandra, P, Sethi, S, Bhargava, M, Arora, P, Tyagi, G, Padmanabhan, T, Malhotra, S, Talwar, K, Shafiq, N, Kasliwal, R, Bansal, M, Eldar, M, Berger, M, Shechter, M, Atar, S, Roguin, N, Kilimnik, M, Hayek, T, Hamoud, S, Katz, A, Plaev, T, Shotan, A, Vazan, A, Weiss, A, Leibowitz, D, Zimlichman, R, Ben-Aharon, J, Hammerman, H, Dragu, R, Rozenman, Y, Witzling, V, Tzivoni, D, Moriel, M, Halkin, A, Sheps, D, Bogomolny, N, Mosseri, M, Khudyak, Y, Halabi, S, Uziel-Iunger, K, Yuval, R, Shimoni, S, Caspi, A, Botwin, S, Gavish, D, Sandler, A, Pollak, A, Kreisberg, B, Hussein, O, Jabal, K, Henkin, Y, Grosbard, A, Rosenschein, U, Rivlin, E, Zeltser, D, Platner, N, Porter, A, Harel, N, Lishner, M, Elis, A, Karny, M, Fuchs, S, Stein, G, Grossman, E, Gealel, Z, Schlaeffer, F, Liberty, I, Golik, A, Tzuman, O, De Ferrari, G, Pavesi, C, Poggio, L, Damiano, S, Pazzano, As, Mennuni, M, Paloscia, L, Mascellanti, M, Piovaccari, G, Grosseto, D, Mascia, F, Vetrano, A, Zingarelli, A, Mazzantini, S, Visconti, L, Terzi, G, Senni, M, Gavazzi, A, Scuri, P, Carmelo, M, De Caterina, R, Conti, M, Novo, S, Graceffa, A, Arvigo, L, Lunetta, M, Filardi, P, Chiariello, M, Scala, O, Pirozzi, E, Musella, F, Moretti, L, Testa, M, Vicentini, A, De Feo, S, Biasucci, L, Cardillo, Mt, Puccioni, E, Galli, M, Menegato, A, Margheri, M, Maresta, A, Gatti, C, Guarini, P, Damiano, M, Golino, P, Porcu, M, Fele, N, Gensini, G, Lombardi, A, Ciuti, G, Bernardi, D, Mariani, P, Paolini, E, Marenzi, G, Moltrasio, M, Terrosu, P, Chessa, P, Guglielmino, G, Miccoli, F, Oldoino, E, Ragni, M, Poli, M, Basso, V, Rapezzi, C, Branzi, A, Gallelli, I, Perna, G, Guazzarotti, F, Marra, S, Usmiani, T, Olivari, Z, Calzolari, D, Santoro, G, Minneci, C, Achilli, A, Nassiacos, D, Sommariva, L, Romeo, F, Fedele, Francesco, Mancone, Massimo, Foschi, Ml, Bruno, N, Centurion, C, Patrizi, G, De Maria, E, Gonnelli, S, Vichi, V, Cassadonte, F, Rotella, G, Capucci, A, Villani, G, Gaspardone, A, Ferrante, R, Scollo, V, Pancaldi, L, Saccà, S, Gabrielli, D, Ciliberti, D, Savini, E, Binaghi, G, Di Biase, M, Ieva, R, Fattore, L, Cicia, G, Cavallini, C, Tamburino, C, Sacco, A, Mafrici, A, Di Pasquale, G, Pavesi, Pc, Scioli, R, Lioy, E, Occhiuzzi, E, Matino, Mg, Russo, V, Moscogiuri, Mg, Cuccia, C, Forgione, C, Volpe, M, Palano, F, Branca, G, Rossi, R, Modena, M, Olaru, Ia, Zanini, R, Cianflone, D, Cristell, N, Pantaleoni, M, Guiducci, U, Menozzi, C, Gaddi, O, Fasulo, A, Indolfi, C, Emanuele, V, Guerra, F, Iliceto, S, Marotta, C, Morocutti, G, Presbitero, P, Rossi, M, Bonatti, S, Grieco, A, Chiodi, L, Betti, I, Zuppiroli, A, Fanelli, R, Stanco, G, Azzolini, P, Ruggieri, C, Bocconcelli, P, Airoldi, F, Tavano, D, Brunelli, C, Caso, P, Scalzone, A, Ghigliotti, G, Facciorusso, A, Sim, K, Kiam, O, Chee, K, Bin Ismail, O, Zambahari, R, Ophuis, T, van Nes, E, Werter, Cj, Ophuis, Aj, Troquay, Rp, Hamer, Bj, Lenderink, T, Feld, Rj, van Hessen MW, Viergever, Ep, van der Sluis, A, Lok, Dj, Badings, Ea, Nierop, Pr, Danse, Iy, Hermans, Wr, Holwerda, Nj, Thijssen, Hj, Theunissen, Lj, van der Zwaan, C, Van Den Berg BJ, Hendriks, Ih, Ronner, E, Withagen, Aj, Dijkshoorn-Giesen, Ah, Ezechiels, Jp, Kuijper, Af, Den Hartog FR, Van Kalmthout PM, Buijs, Em, van der Zeijst, M, Zwart, Pa, Zuidgeest, Ja, van Eck, M, Daniels, Mc, van der Ven-Elzebroek, N, Van 't Hof, A, van Boven AJ, van der Weerdt, A, Dunselman, Ph, Alings, Ma, van Es RF, The, Sh, Gurlek, C, Liem, Ah, van Lennep HW, Van Vlies, B, Kalkman, C, Swart, Hp, van der Bij, P, Taverne, R, Ciampricotti, R, van Dam, C, Spierenburg, H, van Ruijven, I, van Kempen LH, Willems, Ff, Dirkali, A, Stoel, I, Plomp, J, Veldmeijer, S, Tjeerdsma, G, Nijmeijer, R, Van Hal JM, Bartels, Gl, Posma, Jl, Linssen, Gc, Fauser, Cg, Waalewijn, Ra, Groenemeijer, Be, Pos, L, Fast, Jh, Droste, Ht, Westenburg, J, Veenstra, W, Koolen, J, van Loo LW, Smits, W, Milhous, Jg, van Rossum, P, Stuij, S, Scott, R, Richards, Am, Morrison, Z, Devlin, G, Fisher, R, Stewart, R, Benetar, J, Voss, J, Wong, S, Scott, D, Luke, R, Tang, E, Davidson, L, Hamer, A, Wilson, S, Price, R, Hart, H, Turner, A, Jortveit, J, Calic, S, Gundersen, T, Brunvand, H, Fosse, L, Nygaard, O, Gjellefall, B, Gravdal, Sa, Ringstad, R, Atar, D, Clausen, H, Hysing, J, Arvesen, K, Topper, M, Flagstad, E, Graven, T, Haug, Hh, Dalin, L, Al-Ani, R, Otterstad, J, Ausen, K, Aaser, E, Olufsen, M, Halvorsen, S, Gullestad, L, Stueflotten, W, Waage, K, Stødle, Rm, Hall, C, Aase, O, Nordeng, J, Soyland, E, Fageraas, Er, Lied, A, Aske, R, Raouf, N, Johansson, J, Herrscher, T, Skogrand, E, Bjornstad, H, Aagnes, I, Arntsen, Bi, Vegsundvaag, J, Skjold, Me, Velle, H, Aambakk, Mb, Skjetne, O, Byfuglien, A, Rodriguez, J, Galvez, D, Medina, F, Hernandez, Ha, Chavez, V, Morales, R, Huapalla, E, Velasquez, D, Torres, F, Aguirre, O, Yanez, L, Andrade, M, Campos, C, Arce, R, Mogrovejo, W, Osores, F, Bustamante, G, Rodriguez, M, Berrospi, P, Garcia, C, Talledo, M, Navarro, P, Horna, M, Herrera, V, Kadziela, J, Rybicka-Musialik, A, Trusz-Gluza, M, Berger-Kucza, A, Musial, W, Tycinska, A, Gil, R, Gziut, A, Gorny, J, Tyllo, M, Reszka, Z, Mickiewicz-Pawlowska, M, Wrzosek, B, Kosior, J, Staneta, P, Korzeniak, R, Kalarus, Z, Markowicz, E, Miekus, P, Konarzewski, M, Kleinrok, A, Puzniak, M, Grajek, S, Janus, M, Krzyzanowski, M, Hoffmann, A, Muzalewski, P, Polonski, L, Kazik, A, Nowalany-Kozielska, E, Wojciechowska, C, Ponikowski, P, Nawrocka, S, Filipiak, K, Serafin, A, Dubiel, J, Mielecki, W, Ogorek, M, Kopcik, D, Jaworska, K, Skonieczny, G, Kawecka-Jaszcz, K, Bryniarski, L, Tracz, W, Lesniak-Sobelga, A, Jankielewicz, J, Zaluska, R, Trojnar, R, Kawalek, P, Gaciong, Z, Pulkowski, G, Anaszewicz, M, Samul, W, Adamus, J, Cholewa, M, Kubik, L, Szczechowicz, R, Rekosz, J, Kwiatkowska, D, Gajek, J, Mazurek, W, Kominek, M, Siminiak, T, Guzniczak, E, Monteiro, P, Providencia, L, Monteiro, S, Pinho, T, Gavina, C, Sousa, C, Loureiro, J, Ferreira, Ar, Cardoso, A, Araujo, J, Rebolo, I, Catarino, C, Santos, J, Nunes, Lp, Mimoso, J, Marques, N, Leitao, M, Pais, J, Fernandes, A, Diogo, A, Nóbrega, J, Moreira, Ji, Mateus, P, Oliveira, J, Selas, M, Ribeiro, V, Albuquerque, A, Reis, R, Ramos, A, Salazar, F, Nair, D, Ng, Ck, Yeo, D, Wong, A, Funiak, S, Belicova, M, Striezova, I, Krajci, P, Sojka, G, Herman, O, Zemberova, A, Pella, D, Fedacko, J, Banikova, A, Micko, K, Macek, V, Moscovic, M, Vahala, P, Vykoukalova, T, Dzupina, A, Marusakova, M, Stevlik, J, Akubzanova, E, Hatalova, K, Burgess, L, Coetzee, C, Mabin, T, Roos, J, Mohamed, Z, Pillay, T, Corbett, C, Bodenstein, W, Tayob, F, Ebrahim, I, Bolsman, C, Horak, A, Lloyd, E, Pretorius, M, Commerford, P, De Andrade, M, Roux, J, Murray, A, Soma, P, Delport, E, Cassel, G, Van Zyl, L, Cronje, T, Sarvan, M, Moodley, R, Guerra, M, Swanepoel, N, Bayat, J, Klug, E, Hellig, S, Yoon, J, Kim, J, Chung, W, Choi, Y, Cho, M, Lee, S, Kwon, H, Hong, B, Seung, K, Chang, K, Rha, S, Jeong, Mh, Hong, Y, Lee, C, Seong, I, Jeong, J, Tahk, S, Yoon, M, Chae, Sc, Kim, H, Lopez, V, Roldan, Jm, Mancisidor, P, Froufe, J, López, A, Franco, S, Molina, A, Soriano, F, Cobos, M, Mejía, Hd, Sanz, R, Vazquez, A, Garri, F, Esteban, I, Marco, P, Artaecheverria, J, Cequier, A, Esplugas, E, Gonzalez, J, de Sa, E, Armada, E, Worner, F, Hernández, I, Roncales, F, Gomollon, J, del Rio, A, Alameda, J, Basilio, E, Rafols, M, Ferres, R, Molla, C, Pascual, J, Cortada, J, García, C, Iglesias, G, Villa, E, Aros, F, Goya, I, Bueno, M, Pereira, Rv, Clavero, X, Pasaron, Cd, Jorda, R, Pereira, R, Perez, O, de Teresa, E, Navarro, M, de la Guia, F, Lozano, T, Antorrena, I, Aranda, M, Alonso, L, Mirelis, J, Alcasena, S, Paniagua, Va, Juanatey, J, Gregorian, L, Munoz, J, Escorihuela, A, Sanz, A, Flores, A, Garcia, Pa, Alfonso, F, Marin, E, Lozano, A, Bethencourt, A, Grau, A, Rubio, A, Sala, J, Royuela, N, San Jose, J, Bugos, V, de Valdecilla, H, Martin, J, Jimenez, R, Felgueres, M, Escalera, P, Ruiz, R, Bescos, L, Sanchez, I, Chavarri, M, Casares, G, Johanson, P, Hultsberg-Olsson, G, Witt, N, Samad, B, Damm, T, Risenfors, M, Ortgren, L, Henareh, L, Jernberg, T, Berglund, M, Karlsson, J, Koch, A, Lycksell, M, Lundgren, C, Herlitz, J, Sjölin, M, Erlinge, D, Matson, E, Cizinsky, S, Carlsson, F, Ryttberg, B, Johansson, K, Tygesen, H, Bergsten, J, Naslund, U, Sundholm, C, Timberg, I, Wikström, P, Hårdhammar, P, Lisbeth, A, Lund, L, Hage, C, Rosenqvist, U, Grändås, M, Larsson, L, Hammerman, A, Andersson, G, Johansson, S, Bennermo, M, Tjerneld, H, Forsgren, M, Eriksson, K, Eriksson, M, Bengtsson, Po, Yu, W, Ceder-Brolin, K, Stafberg, C, Andersson, E, Roussine, V, Ångman, K, Melin, B, Thorsen, S, Lundell, L, Buijs, F, Östberg, S, Sigaud, P, Moccetti, T, Bondio, M, Kuehlkamp, V, Pieper, M, Gallino, A, Zender, H, Genné, D, Gauthey, J, Wilhelm, M, Saner, H, Trachsel, L, Roethlisberger, C, Schlaepfer, H, Kujawski, T, Pagnamenta, A, Meyer-Monard, S, Krapf, R, Biedermann, B, Schneider, H, Rickli, H, Ramsay, D, Linka, A, Ballmer, P, Oswald, M, Girod, G, Charng, M, Shu-Ling, H, Ping-Han, L, Wu, C, Liu, S, Lin, M, Chian-Yi, W, Yeh, H, Mei-Juan, C, Hsieh, I, Wang, Y, Ural, E, Sahin, T, Yildiz, Z, Kayikcioglu, M, Kultursay, H, Yigit, Z, Calpar, I, Ata, N, Goktekin, O, Senol, U, Yalcin, R, Timurkaynak, T, Kaya, U, Yildirir, A, Karacaglar, E, Faynyk, A, Sorokivskyy, M, Koval, O, Kaplan, P, Kraiz, I, Popova, K, Kyyak, Y, Barnett, O, Karpenko, O, Todoriuk, L, Tseluyko, V, Kopytsya, M, Petyunina, O, Kovalskyy, I, Zhukova, Y, Katerenchuk, I, M'Yakinkova, L, Lutay, Y, Syvolap, V, Kyselov, S, Vakaliuk, I, Nesterak, R, Nikonov, V, Feskov, O, Goloborodko, B, Golovtsev, Y, Berezniakov, I, Lebedynska, M, Rudenko, L, Tutov, I, Ahsan, A, Burton, J, Levy, T, Lakeman, N, Spratt, J, Langford, E, Sutcliffe, S, Khwanda, A, Davis, G, Rodrigues, E, Dickinson, D, Been, M, Trouton, T, Riddell, J, Moriarty, A, Mceneaney, D, Squire, I, Narayan, H, Goode, G, Helliwell, L, Boos, C, Greaves, K, Knops, K, Pegge, N, Signy, M, Wong, Y, Moore, S, Fluck, D, Atkinson, C, Adgey, A, Mckeag, N, Bishop, A, Glover, J, Barbir, M, Breen, J, Robson, H, Townend, J, Dwenger, E, Ekpo, E, Shakespeare, C, Barr, C, Mcclements, B, Mcallister, A, De Belder, M, Cooke, J, Williams, S, Daniel, D, Pye, M, Griffith, K, Wright, L, Trevelyan, J, Doughty, A, Hughes, E, Phillips, C, Penny, W, Groves, P, Kardos, A, Purvis, J, Mcneill, A, Jones, A, Brown, J, Saeed, B, Sprigings, D, Herity, N, Brown, C, Unks, M, Cauthren, T, Bertolet, B, Jones, M, Decker, S, Chambers, J, Stahlberg, J, Varma, S, Gencheff, N, Price, A, Mcelroy, D, Chu, A, Crutchfield, B, Eaton, G, Looney, A, Qureshi, M, Wilks, J, Drenning, D, Overman, A, Andreou, C, Russo, P, Stuckey, T, Pruitt, H, D'Urso, M, Deraad, R, Rogers, W, Thorington, S, Pasquini, J, Iwaoka, R, Tannenbaum, M, Prouty, D, Wiseman, A, Sharow, A, Graham, B, Ali, Mi, Dale, H, Tarsi, D, Picone, M, Juarez, S, Hamroff, G, Hollenweger, L, Scirica, B, Sabatine, M, Marti, J, Perlman, R, Pavlides, A, Joffe, I, Albirini, A, Campbell, T, Puri, S, Lopez, C, Pearce, D, Shah, D, Mcpherson, J, Donegan, R, Murdock, D, Block, D, Malik, A, Musina, R, Dauber, I, Varner, C, Bach, R, Palazzolo, M, Bhalla, H, Thompson, M, Pollock, S, Johnson, S, Lipson, L, Brunk, S, Karas, S, Vicari, R, Kuvin, J, Mooney, P, Aycock, G, Lane, B, Sharma, M, Gibson, T, Chang, G, Divito, P, Mehta, R, Watkins, K, Chiu, A, Gunderson, J, Tedder, B, Williams, P, Hage-Korban, E, Childs, A, Banerjee, S, Kazi, F, Bennett, J, Barnes, D, Wohns, D, Noorman, C, Aggarwal, K, Lau-Sickman, A, Paulowski, J, Amos, M, Rider, J, Fenton, S, Schantz, M, Hakas, J, Mcsorley, J, Felten, W, Bitzer, V, Russell, J, Loyo, J, Adjei, A, Mehta, K, Uretsky, B, Hale, M, Shaikh, S, Miller, M, Hollenbaugh, D, Crawford, K, Fortuin, D, Galindo, A, Del Core, M, Butkus, E, Collins, J, Prior, J, Hahn, R, Greene-Nashold, J, Alexander, J, Genova, E, Macdonell, A, Broadwater, S, Kereiakes, D, White, D, Lopez, M, Schenks, R, Lui, H, Gibbons, P, Davis, B, Thornton, K, Daley, P, Budzon, S, Mccullum, K, Delio-Cox, B, Nadar, V, Keim, S, Mclaurin, B, Davis, C, Betzu, R, Al-Jumaily, J, Bolli, R, Alshaher, M, Leesar, M, Collins, T, Akkad, H, Bilazarian, S, Marsters, M, Kennett, J, Melegrito, K, Mostel, E, Harris, R, Chang, M, Hatfield, G, Makam, S, Garvey, M, Levite, H, White, J, Abdel-Latief, A, Pelletier, L, Carr, K, Mckenna, K, De Lemos, J, Soto, G, Kozina, J, Harris, D, Vlastaris, A, Bittel, B, Riba, A, Gugudis, J, Singh, N, Qureshi, I, Doty, W, Lehmann, J, Lieber, I, Martin, S, Nicu, M, Bhalodkar, N, Ravi, P, Canto, J, Bass, M, Campbell, C, Steinhubl, S, Moles, K, Harjai, K, Stapleton, Dd, Hoey, K, Erwin, J, Fikes, W, Stein, B, Sabatino, K, Teklinski, A, Colfer, H, Ward, P, Langevin, E, Faucett, S, Mamdani, S, Desimone, L, Tuohy, E, Cullen, T, Eisenberg, S, Chronos, N, Allen, Rp, Erickson, B, Mahon, K, Kirby, A, Siegel, C, Stroud, L, Johnson, J, Panchal, V, Pearson, A, Abell, T, De Gregorio, M, Boomer, L, Vahdat, O, Vannatta, B, Long, P, Chalavarya, G, Skatrud, L, Carey, C, Wright, W, Mechem, C, Matthews, B, Adams, A, Vora, K, Wead, J, Koren, M, Gregory, D, El Khadra, M, Peacock, G, Kieval, J, Barron, M, Lewis, D, Grice, R, Bobek, M, Moore, C, Nygaard, T, Fischell, T, Salman, W, Schneider, C, Muhlestein, B, Peeler, D, Chang, D, Todd, A, Chilakamarri, V, Hanley, P, Gelormini, J, Iacona, Ma, Effron, B, Mazzurco, S, Mazzella, M, Wyman, P, Orchard, R, Battin, D, Rezkalla, S, Bishop, C, Sharp, S, Gredler, F, Knap, P, Fadel, M, Saucedo, J, Keng, A, Imburgia, M, Blank, E, Effat, M, Khoury, S, Mardis, R, Baldari, D, Tafuri, L, Mascolo, R, Taylor, D, Mandviwala, M, Khan, W, Mumford, T, Mayer, N, Mitchell, B, Oliver, T, Lombardi, W, Zimmerman, T, Rohrbeck, S, Cooke, L, Craig, M, Mego, D, Griffin, B, Perez, J, Leclerc, K, Addington, J, Aboufakher, R, Ahmed, A, Westecott, B, Steel, K, Hawkins, K, Shah, A, Ward, U, Mcgreevy, M, Goldberg, R, Prashad, R, Mcdonough, C, Silver, K, Josephson, R, Witsaman, S, Labib, S, Woodhead, G, Schrank, J, Bell, K, Chandna, H, Holly, D, Bethea, C, Fife, B, Gruberg, L, Singer, A, Ramgadoo, M, Lalonde, T, Morin, R, French, W, Barillas, O, Gradner, G, Kahn, Z, Gress, J, Rocco, D, Thew, S, Stifter, W, Fisher, M, Mcnamara, J, Kupfer, J, Agocha, A, Cush, S, Jones, S, Whitaker, T, Stover, T, Kumkumian, G, Kent, K, Greenberg, A, Pandey, P, Pytlewski, G, Matsumura, M, Kai, W, Sameshima, S, Thomas, J, Macnicholas, D, Pillai, K, Jones, D, Navas, Jp, Laskoe, B, Patel, P, Fini, G, Minor, S, Shipwash, T, Cabrera-Santamaria, A, Rivera, E, Mincher, L, Jafar, M, Yen, M, Finkle, C, Rahimtoola, A, Severson, L, Labroo, A, Jinich, D, Tam, K, Vogel, C, Aggarwal, R, Zakhary, B, Curtis, S, Lyster, M, Humphrey, K, Lavine, P, Fujise, K, Birnbaum, Y, Allen, J, Kesselbrenner, M, Michel, K, Staniloae, C, Liu, M, Sonel, A, Macioce-Caffas, A, Amidon, T, Leggett, J, Yedinak, S, Gudmundsson, G, Sabharwal, J, Dagefoerde, N, Wu, W, Meyerrose, G, Roongsritong, C, Jenkins, L, Lieberman, S, Sokol, S, Gutierrez, C, Nelson, C, Barrett, J, Hotchkiss, D, Farley, A, Atassi, K, Christy, L, Baig, M, Di Fazio, J, Meengs, M, Thomas, K, Surmitis, J, Devault, S, Farhat, N, Hulyalkar, A, Riddell, L, Rivera, W, Sheynberg, B, Kobayashi, J, Katsaropoulos, J, Jan, M, Krucoff, M, Paterno, C, Chandrasekaran, S, Curry, R, Cassavar, D, Wheeler, M, Mcgarvey, J, Schwarz, L, Miller, E, Andrea, B, Carswell, Bs, Lurie, M, Patti, J, Bowden, W, Vasiliauskas, T, Latham, R, Schwartz, B, Bradford, L, Mattleman, S, Wertheimer, J, Goulden, D, Khan, M, Hawkins, B, Ostfeld, R, Mueller, H, Ash, Y, Wilson, V, Bayer, M, Marshall, J, Dobies, D, Dawson, G, Osman, A, Saba, F, Costello, T, Fuentes, F, Underwood, C, Vijay, N, Washam, M, Dietz, W, Glasgow, B, Mukherjee, S, Hinchion, N, Speirs, S, Thornley, A, Lee, K, Movahed, M, Strootman, D, Chernick, R, Parrott, C, Flock, C, Marques, V, Syzmanski, E, Rama, P, Domingo, D, Wu, L, Bauer, B, Dionisopoulos, P, Aggarwal, A, Holcomb, R, Foster, R, Hancock, T, Hargrove, J, Fletcher, A, Stine, R, Bullivant, M, Adams, K, Lohman, J, Klepper, V, Kabour, A, Neidhardt, J, Phillips, W, Tardiff, S, Aji, J, Corut, S, Foster, G, Firek, C, St Goar, F, Sumner, R, Davis, T, Schneider, R, Schneider, W, Villa, A, Desai, V, Chhabra, A, Banks, K, Herzog, W, Burley, T, Quyyumi, A, Smiley, W, Manocha, P, Fishbein, G, Weller, C, Coffman, A, Kim, C, Kedia, A, Firth, B, Rizvi, M, Dahiya, R, Foster, B, Balcells, E, Metzger, Dc, Lester, J, Bissett, J, Fahdi, I, Sides, Ea, Azrin, M, Martin, C, Quick, A, Conaway, D, Garg, M, Schallert, G, Lancaster, L, Mckissick, S, Atieh, M, Garbarino, J, Eisenberg, D, Uusinarkaus, K, Wirtemburg, P, Ellis, J, Cristaldi, J, Berglund, R, Negus, B, Pappas, J, Rocha, R, Nguyen, T, Stone, J, Janosik, D, Labovitz, A, Elmore, N, Dave, R, Loffredo, K, Gabriel, G, Snyder, C, Ahmed, O, Stone, H, Kelley, M, Diffenback, M, Friedman, B, Zirkle, J, Severa, L, Sample, S, Dignen, K, Raisinghani, A, Ben-Yehuda, O, Ghannadian, B, Moscoso, R, Mankowski, J, Boliek, W, Rukavina, M, Davis, W, Ledbetter, S, Handel, F, Mastouri, R, Mahenthiran, J, Foltz, J, Malhotra, V, Jonas, J, Berk, M, Singh, V, Nelson, M, Elsner, G, Gall, J, Kondo, N, Frank, S, Chandraratna, P, Ranasinghe, S, Ebrahimi, R, Treadwell, M, Walters, B, Hughes, L, Kramer, J, Kumar, K, Mente, T, Lachterman, B, Schifferdecker, B, Munshi, K, Sease, D, Waldo, D, Chandler, G, Manns, D, Nahhas, A, Kamalesh, M, Williams, V, Reich, D, Desalca, M, Sharma, S, Liston, M, Gupta, K, Costa, M, Altschuller, A, Lemmertz, K, Shanes, J, Hansen, C, Therrien, M, Mendelson, R, Ramnarine, R, Myers, G, Donovan, C, Klein, M, Fine, D, Owens, S, Murray, C, Ketroser, R, Heifetz, S, Darnell, Z, Touchon, R, Taghizadeh, B, Bohle, D, Norwood, D, Forrest, T, Jackson, S, Shumate, K, Bayles, A, Masroor, M, North, Wk, Fishberg, R, Merveil-Ceneus, B, Butcher, R, Menapace, F, Kilbride, S, Ramabadran, Rs, Loukinen, K, Khalil, J, Ramabadran, R, Walsh, S, Gill, S, Cyncar, R, Mclachlan, J, Surakanti, V, Rusterholtz, L, Shoukfeh, F, Stephenson, L, Tsang, M, Nolan, V, Gilchrist, I, Jefferson, D, Feldman, T, Reyes, L, Santos, R, Little, W, Wesley, D, Gharib, W, Mendell, A, Esham, G, Kakavas, P, Whitcomb, C, Book, K, Bazzi, A, Alvarez, J, Cohen, Y, Ayres, T, Rhule, V, Labib, A, Schuler, P, Zughaib, M, Telck, K, Bikkina, M, Turnbull, K, Sharma, T, Orosz, S, Shah, R, Petrino, M, Hughes, M, Hershey, J, Hudock, D, Hui, P, Von Bakonyi, A, Arnold, A, Kappel, D, Pennock, G, Cloud, B, Tucker, K, Harp, L, Hoover, C, Eisenhauer, M, Roth, J, Young, C, Thai, H, Escalante, A, Bautista, J, Gazmuri, R, Nyland, J, Cubeddu, L, Defranco, A, Dias, D, Fielding, M, Reeves, R, Hermany, P, Meissner-Dengler, S, Evans, M, Flores, E, Tannenbaum, A, Mcgarr, K, Moran, J, Stout, E, Allred, S, Henderson, D, Crandall, L, Strote, J, Voyles, W, Robeson, D, Bedoya, R, Omar, B, Pettyjohn, F, Revere, C, Coy, K, Margolis, J, Sotolongo, C, Scheffel, M, Munir, A, Shirwany, A, Douglas, L, Girala, R, Humphreys, R, Agarwal, J, Bankowski, D, Watson, R, Bishop, B, Klementowicz, P, Blais, D, Cohen, B, Lobur, E, Dimenna, J, Dempsey, K, Izzo, M, Bondi, L, Carell, E, Eaton, C, Saltiel, F, Grewal, G, Connolly, T, Little, T, Wiegman, P, Gips, S, Held, J, Paraschos, A, Quesada, R, Goudreau, E, Sears, M, Istfan, P, Holt, S, Mcclung, J, Nguyen, N, Quintana, O, Gottlieb, D, Knutson, T, Barringhaus, K, Lester, F, Sullivan, P, Rodriguez-Ospina, L., IMPROVE-IT Investigators, Musliner, T., Tershakovec, A., Gurfinkel, E., Aylward, P., Tonkin, A., Maurer, G., Van de Werf, F., Nicolau, J.C., Theroux, P., Genest, J., Armstrong, P., Corbalan, R., Isaza, D., Spinar, J., Grande, P., Voitk, J., Kesaniemi, A., Bassand, J.P., Farnier, M., Darius, H., Keltai, M., Mathur, A., Mittal, S., Reddy, K., Lewis, B., De Ferrari, G.M., Ophuis, T.O., Jukema, J., White, H., Pedersen, T., Britto, F., Ruzyllo, W., Carrageta, M., Duris, T., Dalby, A., Seung, K.B., Lopez-Sendon, J., Dellborg, M., Mach, F., Guneri, S., Parkhomenko, A., Brady, A., Cannon, C., Blazing, M., Ballantyne, C., de Lemos, J., Kleiman, N., McGuire, D.K., Centeno, E., Casalins, M., Cartasegna, L., Beltrano, M.C., Guerrero, R., Fanuele, M., Berra, F., Egido, J., Colombo, H., Dellatorre, M., Terns, P., Blumberg, E., Reges, P., Azize, G., Ramos, H., Fernandez, R., Carlessi, C., Milesi, R., Schmuck, R., Duronto, E., Procopio, G., Carlevaro, O., Maffeo, H., Beloscar, J., Viso, M., Hominal, M., Castoldi, M., Bluguermann, J., Mauro, D., Macin, S., Cocco, N., Ruiz, N., Ricart, J., Lozada, A., Nani, S., Turri, D., Fernandez, H., Caruso, O., Zarandon, R., Bono, J., Arias, V., Allall, O., Marino, J., Cusimano, S., Schygiel, P., Buzetti, C., Penaloza, N., Berli, M., Worthley, S., Roach, A., Chew, D., Wright, T., Leitch, J., Hicks, E., Rankin, J., Venn-Edmonds, C., Lehman, R., Morrison, H., Shaw, J., Mak, V., Hii, C., Smith, K., Cross, D., Lilwall, L., Nelson, G., Loxton, A., Horowitz, J., Rose, J., Steinwender, C., Leisch, F., Kammler, J., Brussee, H., Zweiker, R., Niederl, E., Weihs, W., Giorgio, G., Lang, I., Drexel, H., Zanolin, D., Hoppe, U., Atzenhofer-Baumgartner, K., Pichler, M., Hainzer, D., Eber, B., Pichler, F., Foeger, B., Wechselberger, T., Mayr, H., Hofer, J., Stockenhuber, F., Warlits, B., Huber, K., Egger, F., Weidinger, F., Ziegler, B., Jirak, P., Metzler, B., Pachinger, O., Wanitschek, M., Auer, J., Grabscheit, G., Podczeck-Schweighofer, A., Priesnitz, T., Frank, H., El Allaf, D., Marechal, P., Roosen, J., Joly, E., Lefebvre, P., Arend, C., Sinnaeve, P., De Velder, L., Hellemans, S., Vanhauwaert, B., Van Dorpe, A., Heyse, A., Vantomme, C., Striekwold, H., Van Den Broeck, D., Lancellotti, P., Schoors, D., Lemoine, I., Taeymans, Y., De Wolf, L., Brike, C., Vercauteren, S., Tahon, S., Vervoort, G., Mestdagh, I., Pirenne, B., Cardinal, F., Lips, S., Dujardin, K., Debrouwer, K., Dhooghe, G., Holvoet, G., van de Borne, P., Renard, M., De Clippel, M., Lesseliers, H., Van Miert, N., Saraiva, J., Vicente, C., Rossi, P., Dos Santos, L.B., Duda, N., Tognon, A.P., Serrano, C., Gomes, F.L., Manenti, E.R., Silveira, D.S., Maia, L., Mouco, O.M., Paiva, M., Antonangelo, A., de Souza, J., Lino, E.A., Leães, P., Blacher, M.G., Kormann, A., Ultramari, F.T., Dutra, O., Mendelski, A.M., Morgado, S., Ardito, W., Greque, G., Ardito, R.V., Pimentel Filho, P., Zucchetti, C., Alves, A., Seabra, A.M., Mattos, M., Miranda, L.F., Silva, D., Uehara, R.M., Marin Neto, J., Schmidt, A., Braga, J., Rodrigues, A., Abrantes, J., Pinheiro, L., Bodanese, L., Magedanz, É.H., Piegas, L., Dos Santos, E.S., Wainstein, M., Ribeiro, J., Stein, R., Marino, R., Machado, V.M., Moraes Junior, J., Guimarães, S., da Costa, F.A., Ferraz, R.F., Albuquerque, D., Rocha, R.M., de Carvalho Moreira, R., Dohmann, H., Costantini, C., Tarastchuk, J.C., Coelho, O., Cirillo, W., Sousa, A., Almeira, A.S., Stefanini, E., Silva, F., Teixeira, M., da Cunha, C., Précoma, D., Facchi, T.L., Rupka, D., Thiessen, S., Warnica, J., Smith, B., Della Siega, A., Klinke, P., Nelson, S., Dion, D., Gilbert, N., Hui, W., Kvill, L., Sussex, B., Luther, A., Dupuis, R., Ouimet, F., Pandey, A., Clarus, S., Senaratne, M., Ferdinandis, H., Mukherjee, A., Bozek, B., Vizel, S., Markov, G., Zimmermann, R., Stephens, W., Tremblay, B., Wong, G., Uchida, N., Brossoit, R., Peck, C., Van Kieu, C., Forgione, M., Bata, I., Cossett, J., Kostuk, W., Arnold, M., Bone, C., Grondin, F., Bilodeau, N., Gosselin, G., David, M., Giannoccaro, J., Beresford, P., Polasek, P., Roberts, P., Doucet, M., Beaudry, M., Cheung, S., Cleveland, T., Bhargava, R., McCallum, A., Ma, P., Morrissette, J., Cleveland, D., Chadwyn, D., Nigro, F., Weeks, A., Cryderman, C., Leader, R., Houde, G., Rousseau, S., Pearce, M., Radyk, M., Lonn, E., Magi, A., Lefkowitz, C., Sandrin, F., Coffin, N., Lubelsky, B., Coldwell, J., Habot, J., McPherson, C., De Larochelliere, R., Roy, M., Haichin, R., Barber, C., Bhesania, T., Kitagawa, H., To, T., Donnelly, B., Tymchak, W., Harris, L., Kouz, S., Huynh, T., St Jacques, B., Lamy, A., Rizzo, A., Stein, J., Childs, C., Wong, B., Poirier, R., Gupta, M., Dela Cruz, C., Constance, C., Gauthier, M., Ervin, F., Ouellette, M., Kokis, A., Lemay, C., Kwok, K., Leung, C., Lee, D., Nesmith, J., Renton, J., Syan, G., Turek, M., Hogan, D., Griffin, P., Lipson, A., Winestock, J., Abramson, B., Fogel, A., Gagne, C., Bergeron, J., Clarke, A., Slipp, S., Darcel, I., Carling-Chambers, L., Kannampuzha, P., Pallie, S., Krekorian, S., Vertes, G., Roth, S., Lai, K., Heath, J., Perez, L., Arriagada, G., Castro, P., Villa, F., Rodríguez, M., Ramos, G., Baraona, F., Núñez, A., García, M., Jofre, C., Silva, P., Lamich, R., Yovaniniz, P., Escobar, E., Dussaubat, A., Segura, E., Ramirez, M., Lapostol, C., Palma, A., Encina, L., Zapata, M., Baeza, N., Varela, P., Pérez, L., Jaramillo, C., Ruiz, S., Sanchez, G., Perdomo, I., Manzur, F., Cohen, L.E., Velasquez, J., Arana, C., Alvarez, Y., Triana, M., Balaguera, J., de Salazar, D., Rendon, N., Botero, R., Ruiz, A., Saaibi, J., Medina, J., Jaramillo, M., Calderón, M.J., Delgado, J., Bohorquez, R., Medina, M.F., Herrera, M., Rosales, D., Mendoza, F., Martinez, S., Ternera, A., Castro, R., Baiz, A., Martinez, M., Orozco, A., Suarez, M., Fonseca, Y., Beltran, R., Cepeda, M., Jaramillo, N., Valenzuela, C., Gutierrez, M., Sanchez, A., Vitovec, J., Hlinomaz, O., Poloczek, M., Mayer, O., Veselka, J., Vejvoda, J., Soucek, M., Spac, J., Novobilsky, K., Srp, V., Francek, L., Branny, M., Sknouril, L., Motovska, Z., Rohac, F., Stankova, A., Fiala, T., Holub, M., Zeman, K., Pohludkova, L., Pospisilova, E., Tuma, P., Cihalik, C., Oral, I., Podpera, I., Stepanovova, R., Uricar, M., Solar, M., Pelouch, R., Porzer, M., Grussmannova, K., Stipal, R., Reichert, P., Hradec, J., Kral, J., Sejkova, B., Janek, B., Pitha, J., Linhart, A., Polacek, P., Koeber, L., Clemmensen, P., Hebin, C.H., Schmidt, E., Pedersen, M.S., Roseva-Nielsen, N., Kristensen, K., Bang-Hansen, T., Jensen, J., Laage-Petersen, J., Nielsen, H., Stokholm, E., Thayssen, P., Cappelen, H., Jensen, T., Winther-Friis, B., Klausen, I., Hedegaard, B., May, O., Andersen, M., Bottzauw, J., Lush, A., Markenvard, J., Vestager, K.M., Bronnum-Schou, J., Hempel, H., Petersen, J., Nielsen, A.J., Thomsen, K., Nielsen, T., Nygaard, A., Sykulski, R., Jensen, B.S., Ralfkiaer, N., Gottschalck, H., Rasmussen, S., Pedersen, L.R., Dodt, K., Skovsbøl, M., Andersen, O., Tuxen, C., Meier, A.W., Kristensen, T., Rasmussen, O., Lopez, J., Salazar, D., Sanchez, L., Rosero, F., Penaherrera, E., Duarte, Y.C., Marmol, R., Andrade, G., Guzman, E., Morillo, A., Aug, L., Loogna, I., Laanmets, P., Mustonen, J., Mäntylä, P., Kesäniemi, A., Ukkola, O., Kervinen, H., Juhela, S., Juvonen, J., Toppinen, A., Jarvenpaa, J., Syvanne, M., Svahn, T., Voutilainen, S., Huotari, A., Nikkila, M., Raiskinmäki, S., Kotila, M., Rajala, A., Laukkanen, J., Hiltunen, P., Melin, J., Nyman, K., Luukkonen, J., Kosonen, P., Huttunen, M., Seppänen, V., Airaksinen, J., Juonala, M., Lehto, S., Savolainen, K., Halkosaari, M., Sia, J., Palomaki, A., Luoma, J., Utriainen, S., Valpas, S., Tiensuu, T., Lilleberg, J., Kainulainen, R., Schiele, F., Bassand, J., Meneveau, N., Galinier, M., Jean, M., Martelet, M., Mouallem, J., Elbaz, M., Puel, J., Carrié, D., Coisne, D., Varroud-Vial, N., Jaboureck, O., Dujardin, J., Leroy, F., Mansourati, J., Funck, F., Jourdain, P., Guillard, N., Coviaux, F., Gay, A., Dourmap-Collas, C., Froger-Bompas, C., Paillard, F., Tricot, O., Maquin-Mavier, I., Dubois-Rande, J.L., Pongas, D., Paris, A.P., Delahaye, F., Ovize, M., Benyahya, L., Bonnet, J., Belle, L., Mangin, L., Lafitte, B., Zemour, G., Doux, N., Agraou, B., El Mansour, N., Traisnel, G., El Jarroudi, M., Ohlmann, P., Diadema, B., Escande, M., Legros, G., Demarcq, J.M., Haftel, Y., Alsagheer, S., Dambrine, P., Cottin, Y., Ghostine, S., Caussin, C., Gacem, A., Bouvier, J.M., Poulard, J., Davy, J., Furber, A., Prunier, F., Muenzel, T., Genth-Zotz, S., Appel, K., Kretzschmar, D., Ferrari, M., Terres, W., Uher, T., Schulze, H., Ochs, H., Morbach, S., Duengen, H., Gross, M., Oezcelik, C., Tahirovic, E., Heuer, H., Laschewski, B., Kadel, C., Rahn, G., Steiner, S., Kreuzer, J., Tsoy, I., Zeiher, A., Muegge, A., Hanefeld, C., Boehm, S., Boudriot, E., Hodenberg, E., Lippe, B., Hausdorf, C., Sydow, K., Baldus, S., Schlesner, C., Tiroch, K., Haltern, G., Guelker, H., Wilhelm, J., Dietz, S., Ebelt, H., Buerke, M., Rupprecht, H., Rittgen, J., Schaeufele, T., Meinhardt, G., Schieber, M., Honold, M., Sieprath, S., Nienaber, C., Hacker, J., Butter, C., Lapp, H., Hirn, S., Pauschinger, M., Zahn, R., Scheffler, U., Schaefer, A., Schieffer, B., Tebbe, U., Kriete, M., Mudra, H., Raeder, T., Braun, P., Zeymer, U., Kouraki, K., Reppel, M., Schunkert, H., Weil, J., Olbrich, H., Schwaiger, P., Mueller, O., Blessing, E., Buss, I., Bohlscheid, V., Kaddatz, J., Skowasch, D., Nickenig, G., Twelker, K., Osterhues, H., Varghese, T., Burghard, S., Kaeaeb, S., Klauss, V., Sohn, H.Y., Hauptmann, K., Schulze, M., Gall, K., Felix, S., Doerr, M., Mante, J., Gulba, D., Freick, M., Werner, G., Kleinertz, K., Hobbach, H.P., Halbach, M., Mueller-Ehmsen, J., Mueller, M.E., Mitrovic, V., Peil, A., Laufs, U., vom Dahl, J., Baumanns, S., Scholtz, W., Wiemer, M., Haude, M., Van de Loo, A., Pistorius, K., Schaefer, J., Schwinger, R., Goeing, O., Jung, W., Birkemeyer, R., Lee, W., Kong, S., Yu, C., Chui, K., Merkely, B., Szelényi, Z., Polgár, P., Svab, S., Herczeg, B., Bajcsi, É., Vértes, A., Davidovits, S., Nagy, A., Király, C., Lupkovics, G., Kenéz, A., Poór, F., Takács, J., Kirschner, R., Simonyi, G., Koncz, J., Édes, I., Gergely, S., Katona, A., Nagy, E., Kovács, Z., Gyetvai, I., Salamon, C., Kolman, É., Sitkei, É., Csapó, K., Molnar, K., Mező, I., Sereg, M., Reddy, P., Manjunath, C., Narayanappa, S., Kumar, S., Sinha, N., Kapoor, A., Christopher, J., Reddy, G., Rani, M., Oomman, A., Ramamurthee, K., Kumar, N., Pasha, S.S., Rao, C., Murty, G.S., Chopra, A., Kapila, D., Bali, H., Chattree, K., Hasan, O., Suryaprakash, G., Rao, D., Babu, R., Bhargavi, M., Naik, S., Khan, S., Chopra, V., Sapra, R., Kaul, U., Ghose, T., Menon, R., Battikadi, S., Mullasari, A., Subban, V.K., Dani, S., Iby, M., Chandra, P., Sethi, S., Bhargava, M., Arora, P., Tyagi, G., Padmanabhan, T., Malhotra, S., Talwar, K., Shafiq, N., Kasliwal, R., Bansal, M., Eldar, M., Berger, M., Shechter, M., Atar, S., Roguin, N., Kilimnik, M., Hayek, T., Hamoud, S., Katz, A., Plaev, T., Shotan, A., Vazan, A., Weiss, A., Leibowitz, D., Zimlichman, R., Ben-Aharon, J., Hammerman, H., Dragu, R., Rozenman, Y., Witzling, V., Tzivoni, D., Moriel, M., Halkin, A., Sheps, D., Bogomolny, N., Mosseri, M., Khudyak, Y., Halabi, S., Uziel-Iunger, K., Yuval, R., Shimoni, S., Caspi, A., Botwin, S., Gavish, D., Sandler, A., Pollak, A., Kreisberg, B., Hussein, O., Jabal, K., Henkin, Y., Grosbard, A., Rosenschein, U., Rivlin, E., Zeltser, D., Platner, N., Porter, A., Harel, N., Lishner, M., Elis, A., Karny, M., Fuchs, S., Stein, G., Grossman, E., Gealel, Z., Schlaeffer, F., Liberty, I., Golik, A., Tzuman, O., De Ferrari, G., Pavesi, C., Poggio, L., Damiano, S., Pazzano, A.S., Mennuni, M., Paloscia, L., Mascellanti, M., Piovaccari, G., Grosseto, D., Mascia, F., Vetrano, A., Zingarelli, A., Mazzantini, S., Visconti, L., Terzi, G., Senni, M., Gavazzi, A., Scuri, P., Carmelo, M., De Caterina, R., Conti, M., Novo, S., Graceffa, A., Arvigo, L., Lunetta, M., Filardi, P., Chiariello, M., Scala, O., Pirozzi, E., Musella, F., Moretti, L., Testa, M., Vicentini, A., De Feo, S., Biasucci, L., Cardillo, M.T., Puccioni, E., Galli, M., Menegato, A., Margheri, M., Maresta, A., Gatti, C., Guarini, P., Damiano, M., Golino, P., Porcu, M., Fele, N., Gensini, G., Lombardi, A., Ciuti, G., Bernardi, D., Mariani, P., Paolini, E., Marenzi, G., Moltrasio, M., Terrosu, P., Chessa, P., Guglielmino, G., Miccoli, F., Oldoino, E., Ragni, M., Poli, M., Basso, V., Rapezzi, C., Branzi, A., Gallelli, I., Perna, G., Guazzarotti, F., Marra, S., Usmiani, T., Olivari, Z., Calzolari, D., Santoro, G., Minneci, C., Achilli, A., Nassiacos, D., Sommariva, L., Romeo, F., Fedele, F., Foschi, M.L., Bruno, N., Centurion, C., Patrizi, G., De Maria, E., Gonnelli, S., Vichi, V., Cassadonte, F., Rotella, G., Capucci, A., Villani, G., Gaspardone, A., Ferrante, R., Scollo, V., Pancaldi, L., Saccà, S., Gabrielli, D., Ciliberti, D., Savini, E., Binaghi, G., Di Biase, M., Ieva, R., Fattore, L., Cicia, G., Cavallini, C., Tamburino, C., Sacco, A., Mafrici, A., Di Pasquale, G., Pavesi, P.C., Scioli, R., Lioy, E., Occhiuzzi, E., Matino, M.G., Russo, V., Moscogiuri, M.G., Cuccia, C., Forgione, C., Volpe, M., Palano, F., Branca, G., Rossi, R., Modena, M., Olaru, I.A., Zanini, R., Cianflone, D., Cristell, N., Pantaleoni, M., Guiducci, U., Menozzi, C., Gaddi, O., Fasulo, A., Indolfi, C., Emanuele, V., Guerra, F., Iliceto, S., Marotta, C., Morocutti, G., Presbitero, P., Rossi, M., Bonatti, S., Grieco, A., Chiodi, L., Betti, I., Zuppiroli, A., Fanelli, R., Stanco, G., Azzolini, P., Ruggieri, C., Bocconcelli, P., Airoldi, F., Tavano, D., Brunelli, C., Caso, P., Scalzone, A., Ghigliotti, G., Facciorusso, A., Sim, K., Kiam, O., Chee, K., Bin Ismail, O., Zambahari, R., Ophuis, T., van Nes, E., Werter, C.J., Ophuis, A.J., Troquay, R.P., Hamer, B.J., Lenderink, T., Feld, R.J., van Hessen, M.W., Viergever, E.P., van der Sluis, A., Lok, D.J., Badings, E.A., Nierop, P.R., Danse, I.Y., Hermans, W.R., Holwerda, N.J., Thijssen, H.J., Theunissen, L.J., van der Zwaan, C., Van Den Berg, B.J., Hendriks, I.H., Ronner, E., Withagen, A.J., Dijkshoorn-Giesen, A.H., Ezechiels, J.P., Kuijper, A.F., Den Hartog, F.R., Van Kalmthout, P.M., Buijs, E.M., van der Zeijst, M., Zwart, P.A., Zuidgeest, J.A., van Eck, M., Daniels, M.C., van der Ven-Elzebroek, N., Van 't Hof, A., van Boven, A.J., van der Weerdt, A., Dunselman, P.H., Alings, M.A., van Es, R.F., The, S.H., Gurlek, C., Liem, A.H., van Lennep, H.W., Van Vlies, B., Kalkman, C., Swart, H.P., van der Bij, P., Taverne, R., Ciampricotti, R., van Dam, C., Spierenburg, H., van Ruijven, I., van Kempen, L.H., Willems, F.F., Dirkali, A., Stoel, I., Plomp, J., Veldmeijer, S., Tjeerdsma, G., Nijmeijer, R., Van Hal, J.M., Bartels, G.L., Posma, J.L., Linssen, G.C., Fauser, C.G., Waalewijn, R.A., Groenemeijer, B.E., Pos, L., Fast, J.H., Droste, H.T., Westenburg, J., Veenstra, W., Koolen, J., van Loo, L.W., Smits, W., Milhous, J.G., van Rossum, P., Stuij, S., Scott, R., Richards, A.M., Morrison, Z., Devlin, G., Fisher, R., Stewart, R., Benetar, J., Voss, J., Wong, S., Scott, D., Luke, R., Tang, E., Davidson, L., Hamer, A., Wilson, S., Price, R., Hart, H., Turner, A., Jortveit, J., Calic, S., Gundersen, T., Brunvand, H., Fosse, L., Nygaard, O., Gjellefall, B., Gravdal, S.A., Ringstad, R., Atar, D., Clausen, H., Hysing, J., Arvesen, K., Topper, M., Flagstad, E., Graven, T., Haug, H.H., Dalin, L., Al-Ani, R., Otterstad, J., Ausen, K., Aaser, E., Olufsen, M., Halvorsen, S., Gullestad, L., Stueflotten, W., Waage, K., Stødle, R.M., Hall, C., Aase, O., Nordeng, J., Soyland, E., Fageraas, E.R., Lied, A., Aske, R., Raouf, N., Johansson, J., Herrscher, T., Skogrand, E., Bjornstad, H., Aagnes, I., Arntsen, B.I., Vegsundvaag, J., Skjold, M.E., Velle, H., Aambakk, M.B., Skjetne, O., Byfuglien, A., Rodriguez, J., Galvez, D., Medina, F., Hernandez, H.A., Chavez, V., Morales, R., Huapalla, E., Velasquez, D., Torres, F., Aguirre, O., Yanez, L., Andrade, M., Campos, C., Arce, R., Mogrovejo, W., Osores, F., Bustamante, G., Rodriguez, M., Berrospi, P., Garcia, C., Talledo, M., Navarro, P., Horna, M., Herrera, V., Kadziela, J., Rybicka-Musialik, A., Trusz-Gluza, M., Berger-Kucza, A., Musial, W., Tycinska, A., Gil, R., Gziut, A., Gorny, J., Tyllo, M., Reszka, Z., Mickiewicz-Pawlowska, M., Wrzosek, B., Kosior, J., Staneta, P., Korzeniak, R., Kalarus, Z., Markowicz, E., Miekus, P., Konarzewski, M., Kleinrok, A., Puzniak, M., Grajek, S., Janus, M., Krzyzanowski, M., Hoffmann, A., Muzalewski, P., Polonski, L., Kazik, A., Nowalany-Kozielska, E., Wojciechowska, C., Ponikowski, P., Nawrocka, S., Filipiak, K., Serafin, A., Dubiel, J., Mielecki, W., Ogorek, M., Kopcik, D., Jaworska, K., Skonieczny, G., Kawecka-Jaszcz, K., Bryniarski, L., Tracz, W., Lesniak-Sobelga, A., Jankielewicz, J., Zaluska, R., Trojnar, R., Kawalek, P., Gaciong, Z., Pulkowski, G., Anaszewicz, M., Samul, W., Adamus, J., Cholewa, M., Kubik, L., Szczechowicz, R., Rekosz, J., Kwiatkowska, D., Gajek, J., Mazurek, W., Kominek, M., Siminiak, T., Guzniczak, E., Monteiro, P., Providencia, L., Monteiro, S., Pinho, T., Gavina, C., Sousa, C., Loureiro, J., Ferreira, A.R., Cardoso, A., Araujo, J., Rebolo, I., Catarino, C., Santos, J., Nunes, L.P., Mimoso, J., Marques, N., Leitao, M., Pais, J., Fernandes, A., Diogo, A., Nóbrega, J., Moreira, J.I., Mateus, P., Oliveira, J., Selas, M., Ribeiro, V., Albuquerque, A., Reis, R., Ramos, A., Salazar, F., Nair, D., Ng, C.K., Yeo, D., Wong, A., Funiak, S., Belicova, M., Striezova, I., Krajci, P., Sojka, G., Herman, O., Zemberova, A., Pella, D., Fedacko, J., Banikova, A., Micko, K., Macek, V., Moscovic, M., Vahala, P., Vykoukalova, T., Dzupina, A., Marusakova, M., Stevlik, J., Akubzanova, E., Hatalova, K., Burgess, L., Coetzee, C., Mabin, T., Roos, J., Mohamed, Z., Pillay, T., Corbett, C., Bodenstein, W., Tayob, F., Ebrahim, I., Bolsman, C., Horak, A., Lloyd, E., Pretorius, M., Commerford, P., De Andrade, M., Roux, J., Murray, A., Soma, P., Delport, E., Cassel, G., Van Zyl, L., Cronje, T., Sarvan, M., Moodley, R., Guerra, M., Swanepoel, N., Bayat, J., Klug, E., Hellig, S., Yoon, J., Kim, J., Chung, W., Choi, Y., Cho, M., Lee, S., Kwon, H., Hong, B., Seung, K., Chang, K., Rha, S., Jeong, M.H., Hong, Y., Lee, C., Seong, I., Jeong, J., Tahk, S., Yoon, M., Chae, S.C., Kim, H., Lopez, V., Roldan, J.M., Mancisidor, P., Froufe, J., López, A., Franco, S., Molina, A., Soriano, F., Cobos, M., Mejía, H.D., Sanz, R., Vazquez, A., Garri, F., Esteban, I., Marco, P., Artaecheverria, J., Cequier, A., Esplugas, E., Gonzalez, J., de Sa, E., Armada, E., Worner, F., Hernández, I., Roncales, F., Gomollon, J., del Rio, A., Alameda, J., Basilio, E., Rafols, M., Ferres, R., Molla, C., Pascual, J., Cortada, J., García, C., Iglesias, G., Villa, E., Aros, F., Goya, I., Bueno, M., Pereira, R.V., Clavero, X., Pasaron, C.D., Jorda, R., Pereira, R., Perez, O., de Teresa, E., Navarro, M., de la Guia, F., Lozano, T., Antorrena, I., Aranda, M., Alonso, L., Mirelis, J., Alcasena, S., Paniagua, V.A., Juanatey, J., Gregorian, L., Munoz, J., Escorihuela, A., Sanz, A., Flores, A., Garcia, P.A., Alfonso, F., Marin, E., Lozano, A., Bethencourt, A., Grau, A., Rubio, A., Sala, J., Royuela, N., San Jose, J., Bugos, V., de Valdecilla, H., Martin, J., Jimenez, R., Felgueres, M., Escalera, P., Ruiz, R., Bescos, L., Sanchez, I., Chavarri, M., Casares, G., Johanson, P., Hultsberg-Olsson, G., Witt, N., Samad, B., Damm, T., Risenfors, M., Ortgren, L., Henareh, L., Jernberg, T., Berglund, M., Karlsson, J., Koch, A., Lycksell, M., Lundgren, C., Herlitz, J., Sjölin, M., Erlinge, D., Matson, E., Cizinsky, S., Carlsson, F., Ryttberg, B., Johansson, K., Tygesen, H., Bergsten, J., Naslund, U., Sundholm, C., Timberg, I., Wikström, P., Hårdhammar, P., Lisbeth, A., Lund, L., Hage, C., Rosenqvist, U., Grändås, M., Larsson, L., Hammerman, A., Andersson, G., Johansson, S., Bennermo, M., Tjerneld, H., Forsgren, M., Eriksson, K., Eriksson, M., Bengtsson, P.O., Yu, W., Ceder-Brolin, K., Stafberg, C., Andersson, E., Roussine, V., Ångman, K., Melin, B., Thorsen, S., Lundell, L., Buijs, F., Östberg, S., Sigaud, P., Moccetti, T., Bondio, M., Kuehlkamp, V., Pieper, M., Gallino, A., Zender, H., Genné, D., Gauthey, J., Wilhelm, M., Saner, H., Trachsel, L., Roethlisberger, C., Schlaepfer, H., Kujawski, T., Pagnamenta, A., Meyer-Monard, S., Krapf, R., Biedermann, B., Schneider, H., Rickli, H., Ramsay, D., Linka, A., Ballmer, P., Oswald, M., Girod, G., Charng, M., Shu-Ling, H., Ping-Han, L., Wu, C., Liu, S., Lin, M., Chian-Yi, W., Yeh, H., Mei-Juan, C., Hsieh, I., Wang, Y., Ural, E., Sahin, T., Yildiz, Z., Kayikcioglu, M., Kultursay, H., Yigit, Z., Calpar, I., Ata, N., Goktekin, O., Senol, U., Yalcin, R., Timurkaynak, T., Kaya, U., Yildirir, A., Karacaglar, E., Faynyk, A., Sorokivskyy, M., Koval, O., Kaplan, P., Kraiz, I., Popova, K., Kyyak, Y., Barnett, O., Karpenko, O., Todoriuk, L., Tseluyko, V., Kopytsya, M., Petyunina, O., Kovalskyy, I., Zhukova, Y., Katerenchuk, I., M'yakinkova, L., Lutay, Y., Syvolap, V., Kyselov, S., Vakaliuk, I., Nesterak, R., Nikonov, V., Feskov, O., Goloborodko, B., Golovtsev, Y., Berezniakov, I., Lebedynska, M., Rudenko, L., Tutov, I., Ahsan, A., Burton, J., Levy, T., Lakeman, N., Spratt, J., Langford, E., Sutcliffe, S., Khwanda, A., Davis, G., Rodrigues, E., Dickinson, D., Been, M., Trouton, T., Riddell, J., Moriarty, A., McEneaney, D., Squire, I., Narayan, H., Goode, G., Helliwell, L., Boos, C., Greaves, K., Knops, K., Pegge, N., Signy, M., Wong, Y., Moore, S., Fluck, D., Atkinson, C., Adgey, A., McKeag, N., Bishop, A., Glover, J., Barbir, M., Breen, J., Robson, H., Townend, J., Dwenger, E., Ekpo, E., Shakespeare, C., Barr, C., McClements, B., McAllister, A., De Belder, M., Cooke, J., Williams, S., Daniel, D., Pye, M., Griffith, K., Wright, L., Trevelyan, J., Doughty, A., Hughes, E., Phillips, C., Penny, W., Groves, P., Kardos, A., Purvis, J., McNeill, A., Jones, A., Brown, J., Saeed, B., Sprigings, D., Herity, N., Brown, C., Unks, M., Cauthren, T., Bertolet, B., Jones, M., Decker, S., Chambers, J., Stahlberg, J., Varma, S., Gencheff, N., Price, A., McElroy, D., Chu, A., Crutchfield, B., Eaton, G., Looney, A., Qureshi, M., Wilks, J., Drenning, D., Overman, A., Andreou, C., Russo, P., Stuckey, T., Pruitt, H., D'Urso, M., DeRaad, R., Rogers, W., Thorington, S., Pasquini, J., Iwaoka, R., Tannenbaum, M., Prouty, D., Wiseman, A., Sharow, A., Graham, B., Ali, M.I., Dale, H., Tarsi, D., Picone, M., Juarez, S., Hamroff, G., Hollenweger, L., Scirica, B., Sabatine, M., Marti, J., Perlman, R., Pavlides, A., Joffe, I., Albirini, A., Campbell, T., Puri, S., Lopez, C., Pearce, D., Shah, D., McPherson, J., Donegan, R., Murdock, D., Block, D., Malik, A., Musina, R., Dauber, I., Varner, C., Bach, R., Palazzolo, M., Bhalla, H., Thompson, M., Pollock, S., Johnson, S., Lipson, L., Brunk, S., Karas, S., Vicari, R., Kuvin, J., Mooney, P., Aycock, G., Lane, B., Sharma, M., Gibson, T., Chang, G., DiVito, P., Mehta, R., Watkins, K., Chiu, A., Gunderson, J., Tedder, B., Williams, P., Hage-Korban, E., Childs, A., Banerjee, S., Kazi, F., Bennett, J., Barnes, D., Wohns, D., Noorman, C., Aggarwal, K., Lau-Sickman, A., Paulowski, J., Amos, M., Rider, J., Fenton, S., Schantz, M., Hakas, J., Mcsorley, J., Felten, W., Bitzer, V., Russell, J., Loyo, J., Adjei, A., Mehta, K., Uretsky, B., Hale, M., Shaikh, S., Miller, M., Hollenbaugh, D., Crawford, K., Fortuin, D., Galindo, A., Del Core, M., Butkus, E., Collins, J., Prior, J., Hahn, R., Greene-Nashold, J., Alexander, J., Genova, E., MacDonell, A., Broadwater, S., Kereiakes, D., White, D., Lopez, M., Schenks, R., Lui, H., Gibbons, P., Davis, B., Thornton, K., Daley, P., Budzon, S., McCullum, K., Delio-Cox, B., Nadar, V., Keim, S., McLaurin, B., Davis, C., Betzu, R., Al-Jumaily, J., Bolli, R., Alshaher, M., Leesar, M., Collins, T., Akkad, H., Bilazarian, S., Marsters, M., Kennett, J., Melegrito, K., Mostel, E., Harris, R., Chang, M., Hatfield, G., Makam, S., Garvey, M., Levite, H., White, J., Abdel-Latief, A., Pelletier, L., Carr, K., Mckenna, K., De Lemos, J., Soto, G., Kozina, J., Harris, D., Vlastaris, A., Bittel, B., Riba, A., Gugudis, J., Singh, N., Qureshi, I., Doty, W., Lehmann, J., Lieber, I., Martin, S., Nicu, M., Bhalodkar, N., Ravi, P., Canto, J., Bass, M., Campbell, C., Steinhubl, S., Moles, K., Harjai, K., Stapleton, D.D., Hoey, K., Erwin, J., Fikes, W., Stein, B., Sabatino, K., Teklinski, A., Colfer, H., Ward, P., Langevin, E., Faucett, S., Mamdani, S., DeSimone, L., Tuohy, E., Cullen, T., Eisenberg, S., Chronos, N., Allen, R.P., Erickson, B., Mahon, K., Kirby, A., Siegel, C., Stroud, L., Johnson, J., Panchal, V., Pearson, A., Abell, T., De Gregorio, M., Boomer, L., Vahdat, O., VanNatta, B., Long, P., Chalavarya, G., Skatrud, L., Carey, C., Wright, W., Mechem, C., Matthews, B., Adams, A., Vora, K., Wead, J., Koren, M., Gregory, D., El Khadra, M., Peacock, G., Kieval, J., Barron, M., Lewis, D., Grice, R., Bobek, M., Moore, C., Nygaard, T., Fischell, T., Salman, W., Schneider, C., Muhlestein, B., Peeler, D., Chang, D., Todd, A., Chilakamarri, V., Hanley, P., Gelormini, J., Iacona, M.A., Effron, B., Mazzurco, S., Mazzella, M., Wyman, P., Orchard, R., Battin, D., Rezkalla, S., Bishop, C., Sharp, S., Gredler, F., Knap, P., Fadel, M., Saucedo, J., Keng, A., Imburgia, M., Blank, E., Effat, M., Khoury, S., Mardis, R., Baldari, D., Tafuri, L., Mascolo, R., Taylor, D., Mandviwala, M., Khan, W., Mumford, T., Mayer, N., Mitchell, B., Oliver, T., Lombardi, W., Zimmerman, T., Rohrbeck, S., Cooke, L., Craig, M., Mego, D., Griffin, B., Perez, J., LeClerc, K., Addington, J., Aboufakher, R., Ahmed, A., Westecott, B., Steel, K., Hawkins, K., Shah, A., Ward, U., McGreevy, M., Goldberg, R., Prashad, R., McDonough, C., Silver, K., Josephson, R., Witsaman, S., Labib, S., Woodhead, G., Schrank, J., Bell, K., Chandna, H., Holly, D., Bethea, C., Fife, B., Gruberg, L., Singer, A., Ramgadoo, M., Lalonde, T., Morin, R., French, W., Barillas, O., Gradner, G., Kahn, Z., Gress, J., Rocco, D., Thew, S., Stifter, W., Fisher, M., McNamara, J., Kupfer, J., Agocha, A., Cush, S., Jones, S., Whitaker, T., Stover, T., Kumkumian, G., Kent, K., Greenberg, A., Pandey, P., Pytlewski, G., Matsumura, M., Kai, W., Sameshima, S., Thomas, J., MacNicholas, D., Pillai, K., Jones, D., Navas, J.P., Laskoe, B., Patel, P., Fini, G., Minor, S., Shipwash, T., Cabrera-Santamaria, A., Rivera, E., Mincher, L., Jafar, M., Yen, M., Finkle, C., Rahimtoola, A., Severson, L., Labroo, A., Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, Cp, Blazing, Ma, Giugliano, Rp, Mccagg, A, White, Ja, Theroux, P, Darius, H, Lewis, B, Ophuis, To, Jukema, Jw, De Ferrari, Gm, Ruzyllo, W, De Lucca, P, Im, K, Bohula, Ea, Reist, C, Wiviott, Sd, Tershakovec, Am, Musliner, Ta, Braunwald, E, Califf, Rm, for the IMPROVE-IT, Investigator, Cianflone, D, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], College of Information Science and Engineering, Ritsumeikan University, Montreal Heart Institute (MONTREAL HEART INSTITUTE), Laboratoire des Micro-algues toxiques, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Interuniversity Cardiology Institute Netherlands, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Merck Sharp & Dohme Corp., Merck & Co. Inc, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Cannon, C.P., Blazing, M.A., Giugliano, R.P., Mccagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., Califf, R.M., for the IMPROVE-IT Investigators [.., C. Rapezzi, ], Other departments, Cannon, Christopher P, Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.

Subjects
Male, Simvastatin, acute coronary syndrome, aged, anticholesteremic agents, azetidines, cardiovascular diseases, cholesterol, ldl, double-blind method, drug therapy, combination, ezetimibe, female, humans, hydroxymethylglutaryl-coa reductase inhibitors, kaplan-meier estimate, male, middle aged, simvastatin, triglycerides, medicine (all, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Bococizumab, Triglyceride, chemistry.chemical_compound, 0302 clinical medicine, Azetidine, Cardiovascular Disease, Anticholesteremic Agent, Acute Coronary Syndrome, Aged, Anticholesteremic Agents, Azetidines, Cardiovascular Diseases, Cholesterol, LDL, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Middle Aged, Triglycerides, 030212 general & internal medicine, Medicine (all), Research Support, Non-U.S. Gov't, Hazard ratio, General Medicine, Acute Coronary Syndrome, Aged, Anticholesteremic Agents, Azetidines, Cardiovascular Diseases, Ezetimibe, Female, Humans, Male, Middle Aged, 3. Good health, Multicenter Study, Editorial, Cholesterol, Randomized Controlled Trial, Combination, Ezetimibe, lipids (amino acids, peptides, and proteins), Human, medicine.drug, medicine.medical_specialty, Acute Coronary Syndroms, Urology, Acute Coronary Syndrome/drug therapy, Anticholesteremic Agents/adverse effects, Anticholesteremic Agents/therapeutic use, Azetidines/adverse effects, Azetidines/therapeutic use, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/mortality, Cardiovascular Diseases/prevention & control, Cholesterol, LDL/blood, Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Simvastatin/therapeutic use, Triglycerides/blood, NO, LDL, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Drug Therapy, Internal medicine, Journal Article, medicine, Comparative Study, Alirocumab, business.industry, PCSK9, ta3121, Lomitapide, DOENÇAS CARDIOVASCULARES, Endocrinology, chemistry, Statin Therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known.METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years.RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (PCONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).

Published
2015
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45. La pianifi cazione territoriale in Catalogna

Author

Juli Esteban i Noguera

Subjects
pianificazione territoriale, lcsh:NA9000-9428, lcsh:HT101-395, lcsh:Human ecology. Anthropogeography, lcsh:GF1-900, Catalogna, paesaggio, lcsh:Aesthetics of cities. City planning and beautifying, lcsh:Urban groups. The city. Urban sociology
Abstract

Il governo autonomo della Catalogna ha assunto dal 1979 la competenza esclusiva inmateria di ordinamento territoriale e pianifi cazione urbanistica. Successivamente, nel1983, il Parlamento ha approvato la Legge sulla Politica Territoriale che ha introdottostrumenti specifi ci: il piano territoriale generale aff ronta il territorio della Catalogna nel suocomplesso, i piani territoriali settoriali si occupano dell’ordinamento di specifi ci settori e ipiani territoriali parziali sviluppano l’ordinamento generale in ambiti più ridotti. Il pianogenerale è stato approvato nel 1995 ed ha carattere programmatorio e strategico, mentrequelli parziali hanno un contenuto di marcato carattere fi sico, eredi della pianifi cazioneurbanistica. Dalla data di approvazione del Piano generale sono stati redatti, e sono oravigenti, piani settoriali e parziali mentre altri sono in corso di elaborazione, di cui si stannoverifi cando solo negli ultimi anni gli impatti sul territorio.

Published
2013

46. Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia

Author

Óscar Pinar López, Fernandez-Esteban I, Maria N Plana, Jesus Maria Fernandez-Tabera, Pilar Martin-Carrillo, Pablo Gómez Álvarez, Almudena Añino Alba, Luis Carlos Saiz, and Jose Manuel Izquierdo-Palomares

Subjects
Medicine General & Introductory Medical Sciences, medicine.medical_specialty, Simvastatin, Statin, Indoles, medicine.drug_class, medicine.medical_treatment, Hyperlipidemias, 030204 cardiovascular system & hematology, Fatty Acids, Monounsaturated, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Lovastatin, Adverse effect, Fluvastatin, Pravastatin, Randomized Controlled Trials as Topic, business.industry, Anticholesteremic Agents, Drug Chronotherapy, Chronotherapy (treatment scheduling), Clinical trial, Regimen, Meta-analysis, lipids (amino acids, peptides, and proteins), business, medicine.drug
Abstract

Background Elevated levels of total cholesterol and low-density lipoprotein play an important role in the development of atheromas and, therefore, in cardiovascular diseases. Cholesterol biosynthesis follows a circadian rhythm and is principally produced at night (between 12:00 am and 6:00 am). The adjustment of hypolipaemic therapy to biologic rhythms is known as chronotherapy. Chronotherapy is based on the idea that medication can have different effects depending on the hour at which it is taken. Statins are one of the most widely used drugs for the prevention of cardiovascular events. In usual clinical practice, statins are administered once per day without specifying the time when they should be taken. It is unknown whether the timing of statin administration is important for clinical outcomes. Objectives To critically evaluate and analyse the evidence available from randomised controlled trials regarding the effects of chronotherapy on the effectiveness and safety of treating hyperlipidaemia with statins. Search methods We searched the CENTRAL, MEDLINE, Embase, LILACS, ProQuest Health & Medical Complete, OpenSIGLE, Web of Science Conference Proceedings, and various other resources including clinical trials registers up to November 2015. We also searched the reference lists of relevant reviews for eligible studies. Selection criteria We included randomised controlled trials (RCTs), enrolling people with primary or secondary hyperlipidaemia. To be included, trials must have compared any chronotherapeutic lipid-lowering regimen with statins and any other statin lipid-lowering regimen not based on chronotherapy. We considered any type and dosage of statin as eligible, as long as the control and experimental arms differed only in the timing of the administration of the same statin. Quasi-randomised studies were excluded. Data collection and analysis We used the standard methodological procedures expected by Cochrane. We extracted the key data from studies in relation to participants, interventions, and outcomes for safety and efficacy. We calculated odds ratios (OR) for dichotomous data and mean differences (MD) for continuous data with 95% confidence intervals (CI). Using the GRADE approach, we assessed the quality of the evidence and we used the GRADEpro Guideline Development Tool to import data from Review Manager to create 'Summary of findings' tables. Main results This review includes eight RCTs (767 participants analysed in morning and evening arms). The trials used different lipid-lowering regimens with statins (lovastatin: two trials; simvastatin: three trials; fluvastatin: two trials; pravastatin: one trial). All trials compared the effects between morning and evening statin administration. Trial length ranged from four to 14 weeks. We found a high risk of bias in the domain of selective reporting in three trials and in the domain of incomplete outcome data in one trial of the eight trials included. None of the studies included were judged to be at low risk of bias. None of the included RCTs reported data on cardiovascular mortality, cardiovascular morbidity, incidence of cardiovascular events, or deaths from any cause. Pooled results showed no evidence of a difference in total cholesterol (MD 4.33, 95% CI -1.36 to 10.01), 514 participants, five trials, mean follow-up 9 weeks, low-quality evidence), low-density lipoprotein cholesterol (LDL-C) levels (MD 4.85 mg/dL, 95% CI -0.87 to 10.57, 473 participants, five trials, mean follow-up 9 weeks, low-quality evidence), high-density lipoprotein cholesterol (HDL-C) (MD 0.54, 95% CI -1.08 to 2.17, 514 participants, five trials, mean follow-up 9 weeks, low-quality evidence) or triglycerides (MD -8.91, 95% CI -22 to 4.17, 510 participants, five trials, mean follow-up 9 weeks, low-quality evidence) between morning and evening statin administration. With regard to safety outcomes, five trials (556 participants) reported adverse events. Pooled analysis found no differences in statins adverse events between morning and evening intake (OR 0.71, 95% CI 0.44 to 1.15, 556 participants, five trials, mean follow-up 9 weeks, low-quality evidence). Authors' conclusions Limited and low-quality evidence suggested that there were no differences between chronomodulated treatment with statins in people with hyperlipidaemia as compared to conventional treatment with statins, in terms of clinically relevant outcomes. Studies were short term and therefore did not report on our primary outcomes, cardiovascular clinical events or death. The review did not find differences in adverse events associated with statins between both regimens. Taking statins in the evening does not have an effect on the improvement of lipid levels with respect to morning administration. Further high-quality trials with longer-term follow-up are needed to confirm the results of this review.

Published
2016

47. Análisis de la base de datos del PRO.DIA.BA en el HIGA Gral. San Martín de La Plata

Author

Cédola, Federico N., Esteban, I., Correa, M. S., Franco, M., and Spezzi, M. I.

Subjects
La Plata (Buenos Aires, Argentina), Ciencias Médicas, Diabetes Mellitus, Planes y Programas de Salud
Abstract

PRODIABA es el Programa de Prevención, Diagnóstico y Tratamiento del Paciente con Diabetes Mellitus (DM) de la Provincia de Buenos Aires. Incluye actualmente 74 mil personas con diabetes. Tiene por objetivos: evitar o disminuir las complicaciones agudas y crónicas de la enfermedad y a través de la asistencia, capacitación (educación diabetológica) y entrega de medicación e insumos en Hospitales y Centros de Salud, incluyendo insulina NPH Humana y regular (viales), análogos de insulina de acción rápida y lenta en lapiceras descartables, tiras reactivas para la determinación de glucemia capilar, jeringas, agujas dígito-punzores y biosensores y agentes orales (ADO): Glibenclamida y Metformina. En el Servicio de Endocrinología del H.I.G.A. Gral. San Martín de La Plata se realizan 4.700 consultas anuales de las cuales corresponden: 50 % a tiroideopatías, 42 % a diabetes y 8 % a otras endocrinopatías. 684 pacientes han sido incorporados al programa en este centro asistencial de tercer nivel., Facultad de Ciencias Médicas

Published
2016

48. Histoplasmosis en el sistema nervioso central en una paciente pediátrica inmunocompetente

Author

Negroni R, Colaboradores, De Cristofano Am, Esteban I, and Minces P

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, medicine.drug_class, business.industry, Mortality rate, 030106 microbiology, Antibiotics, Meningoencephalitis, bacterial infections and mycoses, medicine.disease, Histoplasmosis, 03 medical and health sciences, parasitic diseases, Pediatrics, Perinatology and Child Health, medicine, Disseminated disease, Headaches, medicine.symptom, business, Rare disease
Abstract

Neurohistoplasmosis is a rare disease, most prevalent in immunosuppressed patients, secondary to disseminated disease with a high mortality rate when diagnosis and treatment are delayed. We report a previously healthy 12 year old girl, from a bat infested region of Tucuman Province, Argentine Republic, who developed meningoencephalitis due to Histoplasma capsulatum. Eighteen months prior to admission the patient started with headaches and intermittent fever. The images of the central nervous system showed meningoencephalitis suggestive of tuberculosis. She received antibiotics and tuberculostatic medications without improvement. Liposomal amphotericin B was administered for six weeks. The patient's clinical status improved remarkably. Finally the culture of cerebral spinal fluid was positive for micelial form of Histoplasma capsulatum. The difficulties surrounding the diagnosis and treatment of neurohistoplasmosis in immunocompetent patients are discussed in this manuscript, as it also intends to alert to the presence of a strain of Histoplasma capsulatum with affinity for the central nervous system.

Published
2016
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49. Ethnopteridology of the Guaranís of Misiones Province, Argentina

Author

Ghillean T. Prance, Hector Alejandro Keller, and Esteban I. Meza Torres

Subjects
FERNS AND LYCOPHYTES, biology, media_common.quotation_subject, GUARANI COMMUNITIES, Plant Science, biology.organism_classification, ETHNOBOTANY, Magic (paranormal), Ciencias Biológicas, Geography, PARANA FOREST, Ethnobotany, Ethnology, Fern, Traditional Use, Nomenclature, Ciencias de las Plantas, Botánica, CIENCIAS NATURALES Y EXACTAS, Ecology, Evolution, Behavior and Systematics, media_common
Abstract

An ethnobotanical study was performed of the ferns and lycophytes used by the Guaranı of Misiones Province, Argentina. It was determined that fifty species are used, and details of the uses and the Guaranı names and nomenclature are given and discussed. Fern and lycophytes are used for medicines, crafts, in magic rituals, and marketing of the plants. The most important traditional use of ferns is for medicine and the most important modern use is commercialization for use in horticulture. Fil: Keller, Hector Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Instituto de Botánica del Nordeste (i); Argentina Fil: Meza Torres, Esteban Ismael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Instituto de Botánica del Nordeste (i); Argentina Fil: Prance, Ghillean T.. University Of Reading; Reino Unido

Published
2011
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50. New Records of Ferns from Northeastern Argentina and Uruguay

Author

Esteban I. Meza Torres, Carlos A. Brussa, and Hector Alejandro Keller

Subjects
Ciencias Biológicas, DEPARIA, Geography, SERPOCAULON, Environmental protection, FERN, Plant Science, DORYOPTERIS, Archaeology, Ciencias de las Plantas, Botánica, CIENCIAS NATURALES Y EXACTAS, Ecology, Evolution, Behavior and Systematics
Abstract

Is reported for the first time from ArgentinaDeparia petersenii (Kunze) M. Kato, Doryopteris collina (Raddi) J. Sm.; Ophioglossum reticulatum L. and Serpocaulon latipes (Langsd. & Fisch.) A.R.Sm. are reported for the first time from Uruguay. Serpocaulon catharinae (Langsd. & Fisch.) A. R. Sm is officially documented for the first time for Argentina and Uruguay. Fil: Meza Torres, Esteban Ismael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Instituto de Botánica del Nordeste (i); Argentina Fil: Keller, Hector Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Instituto de Botánica del Nordeste (i); Argentina Fil: Brussa, Carlos A.. Museo y Jardín Botánico "Prof. Atilio Lombardo"; Uruguay

Published
2010
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