1. Factor XIII B Subunit Polymorphisms and the Risk of Coronary Artery Disease
- Author
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Éva Katona, Szilvia Fiatal, Róza Ádány, Zoltán András Mezei, István Édes, István Czuriga, Emilia Balogh, Réka Gindele, Zsuzsanna Bereczky, László Muszbek, and László Balogh
- Subjects
Male ,Fibrinogen ,Gastroenterology ,polymorphism ,Coronary artery disease ,lcsh:Chemistry ,Risk Factors ,Odds Ratio ,Myocardial infarction ,lcsh:QH301-705.5 ,Spectroscopy ,Genetics ,education.field_of_study ,Factor XIII ,risk assessment ,Orvostudományok ,General Medicine ,Middle Aged ,Computer Science Applications ,myocardial infarction ,Female ,coronary artery disease ,medicine.drug ,medicine.medical_specialty ,Heterozygote ,Genotype ,Population ,Klinikai orvostudományok ,Polymorphism, Single Nucleotide ,Article ,Catalysis ,Inorganic Chemistry ,Internal medicine ,medicine ,Humans ,Physical and Theoretical Chemistry ,Allele ,education ,Molecular Biology ,Coronary atherosclerosis ,Alleles ,Aged ,business.industry ,Organic Chemistry ,Case-control study ,Correction ,medicine.disease ,Introns ,factor XIII (FXIII) ,lcsh:Biology (General) ,lcsh:QD1-999 ,Case-Control Studies ,factor XIII B subunit (FXIII-B) ,fibrinogen ,business ,Factor XIIIa - Abstract
The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significant coronary atherosclerosis (CAS) and history of myocardial infarction (MI). The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>, G polymorphisms, the latter results in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIII levels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels.
- Published
- 2015