8 results on '"E. Pencreach"'
Search Results
2. Tumor cell-free DNA detection in CSF for primary CNS lymphoma diagnosis
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I. Harzallah, L. Zalmaï, V. Rimelen, N. Zinniger, Agathe Debliquis, E. Pencreach, Remy Hurstel, F Lamy, I Alamome, Guido Ahle, J. Voirin, and B. Drénou
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Male ,Pathology ,medicine.medical_specialty ,Neurology ,Lymphoma ,Tumor cells ,Free dna ,lcsh:RC346-429 ,Pathology and Forensic Medicine ,Circulating Tumor DNA ,Central Nervous System Neoplasms ,Cellular and Molecular Neuroscience ,Primary CNS Lymphoma ,Biomarkers, Tumor ,Medicine ,Humans ,Letter to the Editor ,lcsh:Neurology. Diseases of the nervous system ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Lymphoma diagnosis ,Retrospective cohort study ,Middle Aged ,Female ,Neurology (clinical) ,business - Published
- 2019
3. OS1.3 Tumor cell-free DNA detection in CSF for primary CNS lymphoma diagnosis
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L. Zalmaï, I Alamome, I. Harzallah, N. Zinniger, J Voirin, Guido Ahle, B. Drénou, E. Pencreach, V. Rimelen, Agathe Debliquis, A Brinet, Remy Hurstel, and F Lamy
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Cancer Research ,medicine.diagnostic_test ,business.industry ,Brain biopsy ,Primary central nervous system lymphoma ,medicine.disease ,Flow cytometry ,Lymphoma ,law.invention ,Oncology ,Cell-free fetal DNA ,law ,Biopsy ,Oral Presentations ,medicine ,Cancer research ,Neurology (clinical) ,business ,Diffuse large B-cell lymphoma ,Polymerase chain reaction - Abstract
BACKGROUND Primary CNS lymphoma (PCNSL) is a rare disease accounting for around 3% of the primary brain tumors. In the vast majority of cases, PCNSL are classified as diffuse large B-cell lymphoma according to the WHO classification. The diagnosis is based on cranial MRI, in combination with a brain biopsy. In case of classical MRI findings, the identification of lymphoma cells in the cerebrospinal (CSF) or vitreous fluid by cytology and flow cytometry might obviate brain biopsy. The presence of the somatic mutation p.Leu265Pro (L265P) in MYD88 is detectable in 50 to 80% of PCNSL, and might also be helpful to confirm the diagnosis. The aim of our study was to evaluate the contribution of a highly sensitive digital droplet PCR, targeting the mutation L265P MYD88, for the detection of tumoral circulating DNA from CSF supernatant. MATERIAL AND METHODS We identified 9 PCNSL expressing the L265P mutation at diagnosis or relapse. The mutation was found by an allele specific PCR technique either on biopsy or in CSF cells. Circulating DNA was isolated from CSF supernatant with the « QiaAmp® circulating nucleic acid» kit. The quantity of DNA collected was estimated by quantitative PCR for a reference gene (albumine) with 7900HT (Life technologies™) device. Subsequently, the L265P MYD88 mutation was quantified by digital droplet PCR Biorad™: The droplets generated were amplified by PCR, detected with the QX200 Reader, and analyzed with the QuantaSoft™ software. RESULTS The circulating DNA concentration was low, varying between 0 and 2.2 ng/mL of CSF. However, the mutation was detected in the circulating DNA from CSF supernatant in 6 out of 9 cases (66%). The fractional abundance varied from 2.6 to 85%. In 3 cases, the mutation was detected even though cytology and flow cytometry did not reveal leptomeningeal disease. For 3 other cases, the mutation was not detected: The genome copy number was below 1 copy/µL, indicating a low analytical sensitivity for theses samples. CONCLUSION This study shows that circulating DNA is present in low concentration in CSF and can be amplified by a sensitive digital PCR for the L265P MYD88 mutation. The detection of circulating PCNSL DNA in CSF is possible and might be used to improve the non-invasive diagnosis of PCNSL. It might also help to select patients for targeted therapies.
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- 2019
- Full Text
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4. BIOLOGY
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J. H. Kim, H. B. Song, D. H. Kim, K. D. Park, B. J. Lee, S. Khatua, E. Kalkan, R. Brown, M. Pearlman, T. Vats, L. Abela, G. Fiaschetti, T. Shalaby, E. Grunder, M. Ma, J. Grahlert, M. Baumgartner, U. Siler, N. Nonoguchi, H. Ohgaki, M. Grotzer, J.-i. Adachi, T. Suzuki, K. Fukuoka, T. Yanagisawa, K. Mishima, T. Koga, M. Matsutani, R. Nishikawa, I. Sardi, L. Giunti, C. Bresci, S. Cardellicchio, M. Da Ros, A. M. Buccoliero, S. Farina, M. Arico, L. Genitori, M. Massimino, L. Filippi, A. Erdreich-Epstein, H. Zhou, X. Ren, M. Schur, T. B. Davidson, L. Ji, R. Sposto, S. Asgharzadeh, Y. Tong, E. White, M. Murugesan, B. Nimmervoll, M. Wang, D. Marino, D. Ellison, D. Finkelstein, S. Pounds, D. Malkin, R. Gilbertson, C. Eden, B. Ju, T. Phoenix, H. Poppleton, C. Lessman, M. Taylor, G. la Marca, S. Malvagia, V. Fratoni, M. G. Giovannini, F. Giangaspero, M. Badiali, V. Gleize, S. Paris, L. Moi, S. Elhouadani, A. Arcella, R. Morace, M. Antonelli, F. Buttarelli, K. Mokhtari, M. Sanson, S. Smith, J. Ward, M. Wilson, C. Rahman, F. Rose, A. Peet, D. Macarthur, R. Grundy, R. Rahman, S. Venkatraman, D. Birks, I. Balakrishnan, I. Alimova, P. Harris, P. Patel, N. Foreman, R. Vibhakar, H. Wu, Q. Zhou, D. Wang, G. Wang, D. Dang, E. Pencreach, A. Nguyen, E. Guerin, C. Lasthaus, D. Guenot, N. Entz-Werle, R. Unland, S. Schlosser, N. Farwick, T. Plagemann, G. Richter, H. Juergens, M. Fruehwald, C.-L. Chien, Y.-H. Lee, C.-I. Lin, J.-Y. Hsieh, S.-C. Lin, T.-T. Wong, D. M.-T. Ho, H.-W. Wang, S. Lagah, I.-L. Tan, S. Malcolm, Y. Majani, D. G. van Vuurden, E. Aronica, L. E. Wedekind, E. Hulleman, D. Biesmans, M. Bugiani, W. P. Vandertop, G. J. L. Kaspers, T. Wurdinger, D. P. Noske, P. M. Van der Stoop, S. Shukla, G. K. Kuipers, B. J. Slotman, J. Cloos, T. Sun, N. Warrington, J. Luo, S. Ganzhorn, U. Tabori, T. Druley, D. Gutmann, J. Rubin, P. Castelo-Branco, S. Choufani, S. Mack, D. Galagher, C. Zhang, T. Lipman, N. Zhukova, D. Martin, D. Merino, J. Wasserman, C. Samuel, N. Alon, J. Hitzler, J. C. Y. Wang, G. Keller, P. B. Dirks, S. Pfister, M. D. Taylor, R. Weksberg, P. Leblond, S. Meignan, A. Dewitte, F. Le Tinier, N. Wattez, E. Lartigau, A. Lansiaux, R. Hanson, I. Gordon, S. Zhao, K. Camphausen, K. Warren, N. M. Warrington, D. H. Gutmann, J. B. Rubin, M. Jaillet, Z. Kovacs, E. Martin-Fiori, M. Bernasconi, B. Werner, C. Dyberg, N. Baryawno, J. Milosevic, M. Wickstrom, P. A. Northcott, M. Kool, P. Kogner, J. I. Johnsen, G. Reynolds, N. Davies, T. Arvanitis, A. Zoghbi, M. Meisterernst, M. C. Fruehwald, K. Kerl, B. Orr, M. Haffner, W. Nelson, S. Yegnasubramanian, C. Eberhart, A. Fotovati, S. Abu-Ali, P.-S. Wang, L. Deleyrolle, C. Lee, J. Triscott, J. Chen, S. Franciosi, Y. Nakamura, Y. Sugita, T. Uchiumi, M. Kuwano, B. Leavitt, S. Singh, A. Jury, C. Jones, H. Wakimoto, B. Reynolds, C. Pallen, S. Dunn, S. Fletcher, J. Levine, M. Li, N. Kagawa, R. Hirayama, Y. Chiba, N. Kijima, H. Arita, M. Kinoshita, N. Hashimoto, S. Izumoto, M. Maruno, and T. Yoshimine
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Abstracts ,Cancer Research ,Oncology ,Neurology (clinical) - Published
- 2012
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5. TUMOUR BIOLOGY
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T. Geller, V. Prakash, J. Batanian, M. Guzman, E. Duncavage, T. Gershon, A. Crowther, J. Wu, H. Liu, F. Fang, I. Davis, D. Tripolitsioti, M. Ma, K. Kumar, J. Grahlert, K. Egli, G. Fiaschetti, T. Shalaby, M. Grotzer, M. Baumgartner, M. Braoudaki, G. I. Lambrou, K. Giannikou, V. Millionis, S. A. Papadodima, N. Settas, G. Sfakianos, K. Stefanaki, A. Kattamis, C. A. Spiliopoulou, F. Tzortzatou-Stathopoulou, E. Kanavakis, S. Gholamin, S. Mitra, A. Feroze, M. Zhang, R. Esparza, S. Kahn, C. Richard, A. Achrol, A. Volkmer, J. Liu, J. Volkmer, R. Majeti, I. Weissman, S. Cheshier, K. Bhatia, N. Brown, J. Teague, P. Lo, J. Challis, V. Beshay, M. Sullivan, F. Mechinaud, J. Hansford, M. Z. Arifin, R. H. Dahlan, M. Sobana, P. Saputra, M. T. Tisell, A. Danielsson, H. Caren, R. Bhardwaj, M. Chakravadhanula, C. Hampton, V. Ozals, J. Georges, W. Decker, V. Kodibagkar, A. Nguyen, M. Legrain, M. P. Gaub, E. Pencreach, M. P. Chenard, D. Guenot, N. Entz-Werle, Y. Kanemura, K. Ichimura, T. Shofuda, R. Nishikawa, M. Yamasaki, S. Shibui, H. Arai, J. Xia, A. Brian, R. Prins, C. Pennell, C. Moertel, M. Olin, L. Bie, X. Zhang, M. Olsson, T. Kling, S. Nelander, V. Biassoni, I. Bongarzone, P. Verderio, M. Massimino, R. Magni, S. Pizzamiglio, C. Ciniselli, E. Taverna, M. De Bortoli, A. Luchini, L. Liotta, E. Barzano, F. Spreafico, E. Visse, E. Sanden, A. Darabi, P. Siesjo, S. Jackson, K. Cohen, D. Lin, P. Burger, F. Rodriguez, X. Yao, R. Liucheng, L. Qin, T. Na, W. Meilin, Z. Zhengdong, F. Yongjun, S. Pfeifer, M. Nister, T. D. de Stahl, E. Basmaci, E. Orphanidou-Vlachou, M.-A. Brundler, Y. Sun, N. Davies, M. Wilson, X. Pan, T. Arvanitis, R. Grundy, A. Peet, C. Eden, B. Ju, T. Phoenix, B. Nimmervoll, Y. Tong, D. Ellison, C. Lessman, M. Taylor, R. Gilbertson, V. Folgiero, F. del Bufalo, A. Carai, M. G. Cefalo, A. Citti, S. Rutella, F. Locatelli, A. Mastronuzzi, O. Maher, S. Khatua, W. Zaky, A. Lourdusamy, L. Meijer, R. Layfield, D. T. W. Jones, D. Capper, M. Sill, V. Hovestadt, L. Schweizer, P. Lichter, D. Zagzag, M. A. Karajannis, K. D. Aldape, A. Korshunov, A. von Deimling, S. Pfister, A. Chakrabarty, R. Feltbower, E. Sheridon, H. Hassan, M. Shires, S. Picton, K. Hatziagapiou, F. Tsorteki, K. Bethanis, V. Gemou-Engesaeth, S. N. Chi, P. Bandopadhayay, K. Janeway, N. Pinches, H. Malkin, M. W. Kieran, P. E. Manley, A. Green, L. Goumnerova, S. Ramkissoon, M. H. Harris, K. L. Ligon, U. Kahlert, M. Suarez, J. Maciaczyk, E. Bar, C. Eberhart, R. Kenchappa, N. Krishnan, P. Forsyth, B. McKenzie, A. Pisklakova, G. McFadden, W. Pan, L. Rodriguez, J. Glod, J. M. Levy, J. Thompson, A. Griesinger, V. Amani, A. Donson, D. Birks, M. Morgan, M. Handler, N. Foreman, A. Thorburn, R. R. Lulla, J. Laskowski, J. Fangusaro, A. J. DiPatri, T. Alden, T. Tomita, E. F. Vanin, S. Goldman, M. B. Soares, M. Remke, V. Ramaswamy, X. Wang, F. Jorgensen, A. S. Morrissy, M. Marra, R. Packer, E. Bouffet, N. Jabado, B. Cole, E. Rudzinski, M. Anderson, K. Bloom, A. Lee, S. Leary, G. Leprivier, B. Rotblat, S. Agnihotri, M. Kool, B. Derry, M. D. Taylor, P. H. Sorensen, T. Dobson, E. Busschers, H. Taylor, R. Hatcher, R. Lulla, V. Rajaram, C. Das, and V. Gopalakrishnan
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Cancer Research ,Abstracts ,Oncology ,Neurology (clinical) - Published
- 2014
6. HIGH GRADE GLIOMAS AND DIPG
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C. F. Classen, D. William, M. Linnebacher, A. Farhod, W. Kedr, B. Elsabe, S. Fadel, S. Van Gool, S. De Vleeschouwer, C. Koks, A. Garg, M. Ehrhardt, M. Riva, P. Agostinis, N. Graf, T.-W. Yao, Y. Yoshida, J. Zhang, T. Ozawa, D. James, T. Nicolaides, R. Kebudi, F. B. Cakir, O. Gorgun, F. Y. Agaoglu, E. Darendeliler, A. Al-Kofide, E. Al-Shail, Y. Khafaga, H. Al-Hindi, M. Dababo, A. U. Haq, M. Anas, M. G. Barria, K. Siddiqui, M. Hassounah, M. Ayas, S. V. van Zanten, M. Jansen, D. van Vuurden, M. Huisman, D. Vugts, O. Hoekstra, G. van Dongen, G. Kaspers, J. Cockle, E. Ilett, K. Scott, A. Bruning-Richardson, S. Picton, S. Short, A. Melcher, M. Benesch, M. Warmuth-Metz, A. O. von Bueren, M. Hoffmann, T. Pietsch, R.-D. Kortmann, M. Eyrich, S. Rutkowski, M. C. Fruhwald, J. Faber, C. Kramm, M. Porkholm, L. Valanne, T. Lonnqvist, S. Holm, B. Lannering, P. Riikonen, D. Wojcik, A. Sehested, N. Clausen, A. Harila-Saari, E. Schomerus, H. K. Thorarinsdottir, P. Lahteenmaki, M. Arola, H. Thomassen, U. M. Saarinen-Pihkala, S.-M. Kivivuori, P. Buczkowicz, C. Hoeman, P. Rakopoulos, S. Pajovic, A. Morrison, E. Bouffet, U. Bartels, O. Becher, C. Hawkins, T. W. A. Gould, C. V. Rahman, S. J. Smith, D. A. Barrett, K. M. Shakesheff, R. G. Grundy, R. Rahman, N. Barua, D. Cronin, S. Gill, S. Lowisl, A. Hochart, C.-A. Maurage, N. Rocourt, M. Vinchon, O. Kerdraon, F. Escande, J. Grill, V. K. Pick, P. Leblond, G. Burzynski, T. Janicki, S. Burzynski, A. Marszalek, N. Ramani, W. Zaky, G. Kannan, A. Morani, D. Sandberg, L. Ketonen, O. Maher, F. Corrales-Medina, H. Meador, S. Khatua, M. Brassesco, L. Delsin, G. Roberto, C. Silva, L. Ana, E. Rego, C. Scrideli, K. Umezawa, L. Tone, S. J. Kim, C.-Y. Kim, I.-A. Kim, J. H. Han, B.-S. Choi, H. S. Ahn, H. S. Choi, F. Haque, R. Layfield, R. Grundy, L. Gandola, E. Pecori, V. Biassoni, E. Schiavello, C. Chiruzzi, F. Spreafico, P. Modena, F. Bach, E. Pignoli, M. Massimino, M. Drogosiewicz, B. Dembowska-Baginska, E. Jurkiewicz, I. Filipek, M. Perek-Polnik, E. Swieszkowska, D. Perek, S. Bender, D. T. Jones, H.-J. Warnatz, B. Hutter, T. Zichner, J. Gronych, A. Korshunov, R. Eils, J. O. Korbel, M.-L. Yaspo, P. Lichter, S. M. Pfister, S. Yadavilli, O. J. Becher, M. Kambhampati, R. J. Packer, J. Nazarian, F. C. Lechon, L. Fowkes, K. Khabra, L. M. Martin-Retortillo, L. V. Marshall, S. Vaidya, D.-M. Koh, M. O. Leach, A. D. Pearson, S. Zacharoulis, D. Schrey, G. Barone, E. Panditharatna, M. Stampar, A. Siu, H. Gordish-Dressman, J. Devaney, E. I. Hwang, A. H. Chung, R. K. Mittapalli, W. F. Elmquist, D. Castel, M.-A. Debily, C. Philippe, N. Truffaux, K. Taylor, R. Calmon, N. Boddaert, L. Le Dret, P. Saulnier, L. Lacroix, A. Mackay, C. Jones, S. Puget, C. Sainte-Rose, T. Blauwblomme, P. Varlet, N. Entz-Werle, C. Maugard, G. Bougeard, A. Nguyen, M. P. Chenard, A. Schneider, M. P. Gaub, M. Tsoli, A. Vanniasinghe, P. Luk, P. Dilda, M. Haber, P. Hogg, D. Ziegler, S. Simon, M. Monje, K. Gurova, A. Gudkov, M. Zapotocky, M. Churackova, B. Malinova, J. Zamecnik, M. Kyncl, M. Tichy, A. Puchmajerova, J. Stary, D. Sumerauer, J. Boult, M. Vinci, L. Perryman, G. Box, A. Jury, S. Popov, W. Ingram, S. Eccles, S. Robinson, S. Emir, H. A. Demir, C. Bayram, F. Cetindag, G. B. Kabacam, A. Fettah, J. Li, Y. Jamin, C. Cummings, J. Bamber, R. Sinkus, M. Nandhabalan, L. Bjerke, A. Burford, A. von Bueren, M. Baudis, P. Clarke, I. Collins, P. Workman, N. Olaciregui, J. Mora, A. Carcaboso, A. Bullock, M. Alonso, C. de Torres, O. Cruz, E. Pencreach, F. M. Moussalieh, D. Guenot, I. Namer, I. Pollack, R. Jakacki, L. Butterfield, R. Hamilton, A. Panigrahy, D. Potter, A. Connelly, S. Dibridge, T. Whiteside, H. Okada, S. Ahsan, E. Raabe, M. Haffner, K. Warren, M. Quezado, L. Ballester, C. Eberhart, F. Rodriguez, C. Ramachandran, S. Nair, K.-W. Quirrin, Z. Khatib, E. Escalon, S. Melnick, M. Hofmann, I. Schmid, T. Simon, E. Maass, A. Russo, G. Fleischhack, M. Becker, H. Hauch, A. Sander, C. Grasso, N. Berlow, L. Liu, L. Davis, E. Huang, P. Woo, Y. Tang, A. Ponnuswami, S. Chen, Y. Huang, M. Hutt-Cabezas, L. Dret, P. Meltzer, H. Mao, J. Abraham, M. Fouladi, M. N. Svalina, N. Wang, E. Hulleman, X.-N. Li, C. Keller, P. T. Spellman, R. Pal, M. H. A. Jansen, A. C. P. Sewing, T. Lagerweij, D. J. Vuchts, D. G. van Vuurden, V. Caretti, P. Wesseling, G. J. L. Kaspers, K. Cohen, M. Pearl, M. Kogiso, L. Zhang, L. Qi, H. Lindsay, F. Lin, S. Berg, J. Muscal, N. Amayiri, U. Tabori, B. Campbel, D. Bakry, M. Aronson, C. Durno, S. Gallinger, D. Malkin, I. Qaddumi, A. Musharbash, M. Swaidan, M. Al-Hussaini, S. Shandilya, C. McCully, R. Murphy, S. Akshintala, D. Cole, R. P. Macallister, R. Cruz, B. Widemann, R. Salloum, A. Smith, M. Glaunert, A. Ramkissoon, S. Peterson, S. Baker, L. Chow, J. Sandgren, S. Pfeifer, S. Popova, I. Alafuzoff, T. D. de Stahl, S. Pietschmann, M. J. Kerber, I. Zwiener, G. Henke, K. Muller, N. Y.-F. Sieow, R. H. M. Hoe, A. M. Tan, M. Y. Chan, S. Y. Soh, K. Burrell, Y. Chornenkyy, M. Remke, B. Golbourn, M. Barzczyk, M. Taylor, J. Rutka, P. Dirks, G. Zadeh, S. Agnihotri, R. Hashizume, Y. Ihara, N. Andor, X. Chen, R. Lerner, X. Huang, M. Tom, D. Solomon, S. Mueller, C. Petritsch, Z. Zhang, N. Gupta, T. Waldman, A. Dujua, J. Co, F. Hernandez, D. Doromal, M. Hegde, A. Wakefield, V. Brawley, Z. Grada, T. Byrd, K. Chow, S. Krebs, H. Heslop, S. Gottschalk, E. Yvon, N. Ahmed, G. Cornilleau, J. Paulsson, F. Andreiuolo, L. Guerrini-Rousseau, B. Geoerger, G. Vassal, A. Ostman, D. W. Parsons, L. R. Trevino, F. Gao, X. Shen, O. Hampton, M. Kosigo, P. A. Baxter, J. M. Su, M. Chintagumpala, R. Dauser, A. Adesina, S. E. Plon, D. A. Wheeler, C. C. Lau, G. Gielen, A. z. Muehlen, R. Kwiecien, J. Wolff, R. R. Lulla, J. Laskowski, S. Goldman, V. Gopalakrishnan, J. Fangusaro, M. Kieran, A. Fontebasso, S. Papillon-Cavanagh, J. Schwartzentruber, H. Nikbakht, N. Gerges, P.-O. Fiset, D. Bechet, D. Faury, N. De Jay, L. Ramkissoon, A. Corcoran, D. Jones, D. Sturm, P. Johann, T. Tomita, M. Nagib, A. Bendel, L. Goumnerova, D. C. Bowers, J. R. Leonard, J. B. Rubin, T. Alden, A. DiPatri, S. Browd, S. Leary, G. Jallo, M. D. Prados, A. Banerjee, A.-S. Carret, B. Ellezam, L. Crevier, A. Klekner, L. Bognar, P. Hauser, M. Garami, J. Myseros, Z. Dong, P. M. Siegel, W. Gump, K. Ayyanar, J. Ragheb, M. Krieger, E. Kiehna, N. Robison, D. Harter, S. Gardner, M. Handler, N. Foreman, B. Brahma, T. MacDonald, H. Malkin, S. Chi, P. Manley, P. Bandopadhayay, L. Greenspan, A. Ligon, S. Albrecht, K. L. Ligon, J. Majewski, N. Jabado, F. Cordero, K. Halvorson, I. Taylor, M. Hutt, M. Weingart, A. Price, M. Kantar, S. Onen, S. Kamer, T. Turhan, O. Kitis, Y. Ertan, N. Cetingul, Y. Anacak, T. Akalin, Y. Ersahin, G. Mason, C. Ho, F. Crozier, G. Vezina, R. Packer, E. Hwang, S. Gilheeney, N. Millard, K. DeBraganca, Y. Khakoo, K. Kramer, S. Wolden, M. Donzelli, C. Fischer, M. Petriccione, I. Dunkel, S. Afzal, A. Fleming, V. Larouche, S. Zelcer, D. L. Johnston, M. Kostova, C. Mpofu, J.-C. Decarie, D. Strother, L. Lafay-Cousin, D. Eisenstat, C. Fryer, J. Hukin, M. Hsu, J. Lasky, T. Moore, L. Liau, T. Davidson, R. Prins, T. Hassal, J. Baugh, J. Kirkendall, R. Doughman, J. Leach, B. Jones, L. Miles, D. Hargrave, T. Jacques, S. Savage, D. Saunders, R. Wallace, B. Flutter, D. Morgenestern, E. Blanco, K. Howe, M. Lowdell, E. Samuel, A. Michalski, J. Anderson, Y. Arakawa, K. Umeda, K.-i. Watanabe, T. Mizowaki, M. Hiraoka, H. Hiramatsu, S. Adachi, T. Kunieda, Y. Takagi, S. Miyamoto, S. Venneti, M. Santi, M. M. Felicella, L. M. Sullivan, I. Dolgalev, D. Martinez, A. Perry, P. W. Lewis, D. C. Allis, C. B. Thompson, and A. R. Judkins
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Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,03 medical and health sciences ,Abstracts ,0302 clinical medicine ,Text mining ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Published
- 2014
7. [Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults]
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M, Martinot, Y, Hansmann, S, De Martino, O, Lesens, G, Coumaros, E, Pencreach, M, Bertrand, and D, Christmann
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Adult ,Calcitonin ,Inflammation ,Male ,Pyelonephritis ,Calcitonin Gene-Related Peptide ,Fibrinogen ,Blood Sedimentation ,Middle Aged ,Community-Acquired Infections ,Leukocyte Count ,C-Reactive Protein ,Reference Values ,Pneumonia, Bacterial ,Humans ,Female ,Protein Precursors - Abstract
Procalcitonin (PCT) is an acute-phase protein involved in the specific inflammatory reaction to severe bacterial or fungal infections. This protein does however lack sensitivity in focal infections.In this study, we investigated PCT, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocytosis, and fibrinogen levels at admission among adult patients hospitalized for community-acquired pneumonia (n = 33) or pyelonephritis (n = 30) and in a control population (n = 27) of patients with viral infections and non-infectious inflammatory diseases.Median serum PCT in the control group (0.21 ng/ml) was significantly lower than in the pyelonephritis group (0.46 ng/ml, p0.0005) or the pneumonia group (0.88 ng/ml, p0.0005). In the control group, median CRP was 51.4 ng/l reaching 220 mg/l in the pyelonephritis and 198 mg/l in the pneumonia group (p0.0005 in both cases). The other markers of inflammation investigated (leukocytosis, ESR, fibrinogen) did not show such differences between the control group and the sepsis groups. The sensitivity of PCT (threshold 0.5 ng/ml) was 61% for the diagnosis of pneumonia and 44% for the diagnosis of pyelonephritis. Specificity was 92% in both cases. In comparison, the sensitivity of CRP (threshold 50 mg/l) was 94% and 91% for pyelonephritis and pneumonia respectively with a 33% specificity in both cases.PCT is a specific but poorly sensitive marker of community-acquired pneumonia and pyelonephritis among adults hospitalized in medical wards.
- Published
- 2001
8. Coexistence of the methylene tetrahydrofolate reductase (MTHFR) Cs77T, the factor II G20210A and the factor V Leiden mutations in idiopathic portal vein thrombosis
- Author
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P CHAMOUAR, A VOEGELI, E PENCREACH, A MEYER, M GAUB, L GRUNEBAUM, F MALOISEL, J ARDIZZONE, R BAUMANN, and G HAUPTMANN
- Subjects
Hepatology ,Gastroenterology - Published
- 2001
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