1. [Adverse side effects of anticancer drugs in treatment of children with acute lymphoblastic leukemia]
- Author
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S V, Babak, A A, Korzhenkov, N I, Samarov, E G, Boichenko, M A, Goeva, A Yu, Voloshina, V R, Miftakhova, and A N, Pankina
- Subjects
Male ,Adolescent ,Child, Preschool ,Humans ,Infant ,Antineoplastic Agents ,Female ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Child - Abstract
The introduction of acute leukemia chemotherapy programs in clinical practice improved effectiveness of treatment and patients' survival rate. However there is a high incidence of anticancer drugs toxicity leading to a decrease in therapeutic effect of treatment. Acute lymphoblastic leukemia (ALL) is a leader among oncohematological pathologies in childhood and adolescence. Its share is 20 % of all malignancies and up to 75% of all leukemias. Treatment for ALL in childhood is one of the most impressive achievements of medicine in recent years. Modern chemotherapy programs can achieve healing in 80 % of patients with ALL, and the researchers are facing new challenges to achieve a high safety profile of treatment. Chemotherapy toxicity frequency varies from 5% to 30 %. This review presents summarized literature analysis on the clinical symptoms of toxic reactions and the ways to prevent and correct developed adverse drug reactions.
- Published
- 2019