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2. Structured reporting for fibrosing lung disease: a model shared by radiologist and pulmonologist

Author

Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, Volterrani, Luca, Sverzellati, N, Odone, A, Silva, M, Polverosi, R, Florio, C, Cardinale, L, Cortese, G, Addonisio, G, Zompatori, M, Dalpiaz, G, Piciucchi, S, Larici, A, Agostini, C, Albera, C, Attinà, D, Battista, G, Bertelli, E, Bertorelli, G, Bnà, C, Bonifazi, M, Bonomo, L, Borghesi, A, Calandriello, L, Caminati, A, Capannelli, D, Cerri, S, Ciccarese, F, Colombi, D, Confalonieri, M, Del Ciello, A, della Casa, G, Dore, R, Falaschi, F, Farchione, A, Feragalli, B, Franchi, P, Gavelli, G, Harari, S, Luppi, F, Maggi, F, Mazzei, M, Mereu, M, Milanese, G, Palmucci, S, Patea, R, Pesci, A, Piolanti, M, Poletti, V, Rea, G, Richeldi, L, Rogliani, P, Romei, C, Rottoli, P, Sanduzzi-Zamparelli, A, Sebastiani, A, Sergiacomi, G, Soardi, G, Spaggiari, L, Spagnolo, P, Tomassetti, S, Trisolini, R, Valentini, A, Vancheri, C, Vespro, V, Volterrani, L, Sverzellati, N., Odone, A., Silva, M., Polverosi, R., Florio, C., Cardinale, L., Cortese, G., Addonisio, G., Zompatori, M., Dalpiaz, G., Piciucchi, S., Larici, A. R., Agostini, C., Albera, C., Attina, D., Battista, G., Bertelli, E., Bertorelli, G., Bna, C., Bonifazi, M., Bonomo, L., Borghesi, A., Calandriello, L., Caminati, A., Capannelli, D., Cerri, S., Ciccarese, F., Colombi, D., Confalonieri, M., Del Ciello, A., Della Casa, G., Dore, R., Falaschi, F., Farchione, A., Feragalli, B., Franchi, P., Gavelli, G., Harari, S., Luppi, F., Maggi, F., Mazzei, M. A., Mereu, M., Milanese, G., Palmucci, S., Patea, R. L., Pesci, A., Piolanti, M., Poletti, V., Rea, G., Richeldi, L., Rogliani, P., Romei, C., Rottoli, P., Sanduzzi-Zamparelli, A., Sebastiani, A., Sergiacomi, G., Soardi, G. A., Spaggiari, L., Spagnolo, P., Tomassetti, S., Trisolini, R., Valentini, A., Vancheri, C., Vespro, V., Volterrani, L., Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, and Volterrani, Luca

Subjects
Male, Research Report, Radiology, Nuclear Medicine and Imaging, Delphi Technique, Settore MED/10 - Malattie dell'Apparato Respiratorio, Pulmonary Fibrosis, Delphi method, Computed tomography, Standardized report, Consensus,High-resolution computed tomography, Lung fibrosis, Standardized report, Structured report, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Theoretical, Models, Nuclear Medicine and Imaging, Pulmonary Medicine, Prospective Studies, Tomography, Pulmonologists, High-resolution computed tomography, computer.programming_language, medicine.diagnostic_test, General Medicine, Middle Aged, X-Ray Computed, 030220 oncology & carcinogenesis, Consensus, Lung fibrosis, Structured report, Female, Radiology, Delphi round, Adult, Aged, Humans, Models, Theoretical, Tomography, X-Ray Computed, medicine.medical_specialty, Chest Radiology, education, Lung fibrosi, Consensu, 03 medical and health sciences, Settore MED/36 - Diagnostica per Immagini e Radioterapia, Structured reporting, medicine, business.industry, Pulmonologist, Lung disease, business, computer, Delphi
Abstract

Objectives To apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD). Methods The writing committee selected the HRCT criteria—the Delphi items—for rating from both radiology panelists (RP) and pulmonology panelists (PP). The Delphi items were first rated by RPs as “essential”, “optional”, or “not relevant”. The items rated “essential” by

Published
2017

3. Mutational profiling of EGFR and KRAS oncogenes in non-small cell lung cancer (NSCLC) cells obtained through fine needle aspiration cytology (FNAC)

Author

Cemmi, Francesca, Stella, Giulia Maria, Zorzetto, Michele, Inghilleri, Simona, Morbini, Patrizia, Dore, Roberto, and Pozzi, Ernesto

Abstract

Cancer is a genetic disease and this concept has now been widely exploited by both biologists and clinicians to design new targeted therapeutical approaches. Indeed many data have already allowed us to ameliorate not only our knowledge about cancer onset, but also about patient treatment. Correlation between mutations in cancer alleles and drug response is a crucial point to identify drugs or drug combinations that match the genetic profile of individual tumors. On the other hand, experiences derived from receptor tyrosine kinases (RTKs) inhibition have pointed out that targeted treatment is really successful only in a small subset of tumors. The latter are eventually addicted to the genetic alterations responsible for receptors activation and continued expression of their signaling pathways. Therefore, switching off the oncogenic activity by specific inhibitors will trigger an “oncogenic shock” which eventually will lead tumor cell to die. Overall these observations provide a strong rationale for molecular-based diagnosis and cancer patients selection for targeted treatment. Understanding how the mutational status of oncogenic alleles affects sensibility or resistance to drugs represents the most potential strategy in identifying patients for effective personalized therapies. In consideration of the high incidence and the poor prognosis of affected patients, lung carcinoma has been considered and still identify major objective of the targeted therapeutic approach. Experiences derived from this disease, and mainly from non-small cell lung cancer (NSCLC), represent fundamental achievement of translational research. From this perspective, members of the EGFR signal transduction pathway play a key role in lung carcinogenesis and act as genetic markers predictive of response to anti-EGFR therapy. In unselected NSCLCs EGFR activating mutations are rarely present (10%); mutation frequency increases to over 50% in a restricted subset of NSCLC patients: East-Asian, women, non smokers, affected by ADC (mainly BAC variant). Moreover the incidence of EGFR mutations in NSCLCs increases up to 77% among EGFR TKIs responders, while it is 7% in unsensitive cases. This project aims to evaluate in a cohort of NSCLC patients the prevalence of activating mutations in EGFR and KRAS genes by analyzing tumor cells obtained through transthoracic biopsy by FNAC, which actually represents the most appropriate diagnostic tool for peripheral lesions, such as ADKs that actually account for 40% of NSCLC diagnosis. Validation of sequencing technology on tumor samples constituted by only few cells has two relevant implications. First it might allows routinary tumor molecular profiling as powerful integration of conventional histo-pathological diagnosis. Besides the clinical management of NSCLC will take advantages from the characterization of EGFR-KRAS mutational status in order to develop personalized and effective treatment strategies., Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 2 (2010)

Published
2010
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