1. Reduced global longitudinal strain at rest and inadequate blood pressure response during exercise treadmill testing in male heterozygous familial hypercholesterolemia patients
- Author
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George Karatasakis, George Athanassopoulos, Iakovos Armenis, Vasiliki Vartela, Konstantinos Makrilakis, Dimitra Leivadarou, Sophie Mavrogeni, G. Kolovou, Despina Perrea, and Konstantinos Toutouzas
- Subjects
Global longitudinal strain ,BP, blood pressure ,medicine.medical_specialty ,Exercise treadmill test ,CAD, coronary artery disease ,Diastole ,DBP, diastolic blood pressure ,Familial hypercholesterolemia ,Coronary artery disease ,EDV, end-diastolic volume ,Bruce protocol ,Internal medicine ,LDL, low-density lipoprotein ,Heart rate ,Internal Medicine ,Medicine ,Diseases of the circulatory (Cardiovascular) system ,hoFH, homozygous familial hypercholesterolemia ,Ejection fraction ,HR, heart rate ,TG, triglyceride ,business.industry ,SBP, systolic blood pressure ,RPP, rate pressure product ,medicine.disease ,HDL, high density lipoprotein ,ESV, end-systolic volume ,FH, Familial hypercholesterolemia ,TC, total cholesterol ,LVEF, LV ejection fraction ,Rate pressure product ,Blood pressure ,heFH, heterozygous familial hypercholesterolemia ,LV, left ventricle ,RC666-701 ,ETT, Exercise treadmill test ,Cardiology ,Arterial blood pressure ,GLS, Global longitudinal strain ,Heterozygous familial hypercholesterolemia ,METs, metabolic equivalents ,Cardiology and Cardiovascular Medicine ,business ,Research Paper - Abstract
Background Heterozygous familial hypercholesterolemia (heFH) is a genetic disorder leading to premature coronary artery disease (CAD). We hypothesized that the subclinical pathophysiologic consequences of hypercholesterolemia may be detected before the occurrence of clinically overt CAD by stress testing and myocardial strain imaging. Patients-methods We evaluated the treadmill tests (ETTs) of 46 heFH men without known arterial hypertension/diabetes mellitus/vasculopathy like CAD and of 39 healthy men matched for age, baseline systolic/diastolic blood pressure (BP) and heart rate (HR), using Bruce protocol. Global longitudinal strain (GLS) of the left ventricle (LV) additionally to ejection fraction was obtained. Results heFH men reached a significantly higher peak systolic and diastolic BP compared to controls (p = 0.002 and p, Highlights • Stress testing and myocardial strain imaging may detect subclinical consequences of heterozygous familial hypercholesterolemia. • Male patients with heFH underwent exercise treadmill testing and speckle-tracking echocardiography. • Male heFH patients showed a higher rise in systolic/diastolic blood pressure during exercise treadmill testing than healthy controls. • Global longitudinal strain of heFH males is slightly impaired compared with healthy subjects.
- Published
- 2021