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6 results on '"Di Concilio, Rosanna"'

1. Additional file 1 of Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia

Author

Manara, Renzo, Ponticorvo, Sara, Perrotta, Silverio, Barillari, Maria Rosaria, Costa, Giuseppe, Brotto, Davide, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Carafa, Pasquale Alessandro, Canna, Antonietta, Russo, Andrea Gerardo, Troisi, Donato, Caiazza, Martina, Ammendola, Federica, Roberti, Domenico, Santoro, Claudia, Picariello, Stefania, Valentino, Maria Sole, Inserra, Emanuela, Carfora, Roberta, Cirillo, Mario, Raimo, Simona, Santangelo, Gabriella, di Salle, Francesco, Esposito, Fabrizio, and Tartaglione, Immacolata

Abstract

Additional file 1. Audiological, Cognitive functioning, MRI data evaluation. S. Fig.1. Relative auditory cortex perfusion values among patients with auditory evaluation. e-Table. Pearson’s correlations between cognitive scores derived by the WAIS and right and left auditory/visual cerebral area perfusion ratio in healthy controls and patients.

Published
2021
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2. Vaccinazione Antinfluenzale in soggetti con Asplenia: warning in tempo di Coronavirus

Author

Di Maio Nicoletta, Barella, Susanna, Graziadei, Giovanna, Forni, Gianluca, Perrotta, Silverio, Allò, Massimo, Sau, Antonella, Balocco, Manuela, Di Concilio Rosanna, Rivellini, Flavia, Facchini, Elena, Peluso, Angelo, Russo, Giovanna, Rigoli, Luciana, Farruggia, Piero, Campisi, Saveria, Casini, Tommaso, Boscarol, Gianluca, Capolsini, Ilaria, Colombatti, Raffaella, Grotto, Paolo, Giona, Fiorina, Lazzareschi, Ilaria, Pugliese, Pellegrina, Fioredda, Francesca, Notarangelo Lucia Dora, Fasoli, Silvia, Putti Maria Caterina, Casciana Maria Luisa, Migliavacca, Maddalena, Corti, Paola, Tripodi, Serena, Saracco, Paola, Ferrero, Simone, Tornesello, Assunta, Serra, Marilena, Ladogana, Saverio, Palazzi, Giovanni, Verzegnassi, Federico, Baronci, Carlo, Palumbo, Giuseppe, Cesaro, Simone, and Casale, Maddalena

Published
2020

3. Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia

Author

Claudia Santoro, Sara Ponticorvo, Giuseppe Costa, Elisa De Michele, Rosanna Di Concilio, Maria Rosaria Barillari, Simona Raimo, Maria Sole Valentino, Mario Cirillo, Emanuela Inserra, Renzo Manara, Donato Troisi, Angela Ciancio, Roberta Carfora, Martina Caiazza, Antonietta Canna, Francesco Di Salle, Pasquale Alessandro Carafa, Domenico Roberti, Andrea G. Russo, Federica Ammendola, Davide Brotto, Immacolata Tartaglione, Stefania Picariello, Fabrizio Esposito, Silverio Perrotta, Gabriella Santangelo, Manara, Renzo, Ponticorvo, Sara, Perrotta, Silverio, Barillari, Maria Rosaria, Costa, Giuseppe, Brotto, Davide, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Carafa, Pasquale Alessandro, Canna, Antonietta, Russo, Andrea Gerardo, Troisi, Donato, Caiazza, Martina, Ammendola, Federica, Roberti, Domenico, Santoro, Claudia, Picariello, Stefania, Valentino, Maria Sole, Inserra, Emanuela, Carfora, Roberta, Cirillo, Mario, Raimo, Simona, Santangelo, Gabriella, di Salle, Francesco, Esposito, Fabrizio, and Tartaglione, Immacolata

Subjects
medicine.medical_specialty, Hearing loss, Hearing Loss, Sensorineural, Thalassemia, Auditory area, Perfusion scanning, Sensorineural, Auditory cortex, Audiometry, Internal medicine, Humans, Medicine, Pharmacology (medical), Genetics (clinical), Auditory Cortex, Brain, Perfusion, Transfusion medicine, Audiometry, Pure-Tone, Cross-Sectional Studies, beta-Thalassemia, medicine.diagnostic_test, business.industry, Research, General Medicine, medicine.disease, Cardiology, Sensorineural hearing loss, Pure tone audiometry, medicine.symptom, business, Pure-Tone
Abstract

Background Sensorineural hearing loss in beta-thalassemia is common and it is generally associated with iron chelation therapy. However, data are scarce, especially on adult populations, and a possible involvement of the central auditory areas has not been investigated yet. We performed a multicenter cross-sectional audiological and single-center 3Tesla brain perfusion MRI study enrolling 77 transfusion-dependent/non transfusion-dependent adult patients and 56 healthy controls. Pure tone audiometry, demographics, clinical/laboratory and cognitive functioning data were recorded. Results Half of patients (52%) presented with high-frequency hearing deficit, with overt hypoacusia (Pure Tone Average (PTA) > 25 dB) in 35%, irrespective of iron chelation or clinical phenotype. Bilateral voxel clusters of significant relative hypoperfusion were found in the auditory cortex of beta-thalassemia patients, regardless of clinical phenotype. In controls and transfusion-dependent (but not in non-transfusion-dependent) patients, the relative auditory cortex perfusion values increased linearly with age (p p = 0.01, left side p = 0.02) with its domain related to communication skills (right side p = 0.04, left side p = 0.07) in controls but not in beta-thalassemia patients. Audiometric test results did not correlate to cognitive test scores in any subgroup. Conclusions In conclusion, primary auditory cortex perfusion changes are a metabolic hallmark of adult beta-thalassemia, thus suggesting complex remodeling of the hearing function, that occurs regardless of chelation therapy and before clinically manifest hearing loss. The cognitive impact of perfusion changes is intriguing but requires further investigations.

Published
2021
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4. Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multi-center nation-wide cohort

Author

Raffaella Origa, Antonella Sau, Maria Caterina Putti, Maurizio Poggi, Gian Luca Forni, Antonella Quarta, Alessandro Cattoni, Marilena Serra, Immacolata Tartaglione, Domenico Roberti, Elena Cassinerio, Elisa De Michele, Patrizia Sturiale, Filomena Sportelli, Saveria Campisi, Antonio Ivan Lazzarino, Massimo Allò, Silverio Perrotta, Rosanna Di Concilio, Daniela Pasquali, Alessia Marcon, Angelo Peluso, Stefania Picariello, Maddalena Casale, Francesca Ferrara, Roberta Renni, Saverio Ladogana, Lucia Dora Notarangelo, Casale, Maddalena, Luca Forni, Gian, Cassinerio, Elena, Pasquali, Daniela, Origa, Raffaella, Serra, Marilena, Campisi, Saveria, Peluso, Angelo, Renni, Roberta, Cattoni, Alessandro, De Michele, Elisa, Allò, Massimo, Poggi, Maurizio, Ferrara, Francesca, Di Concilio, Rosanna, Sportelli, Filomena, Quarta, Antonella, Caterina Putti, Maria, Dora Notarangelo, Lucia, Sau, Antonella, Ladogana, Saverio, Tartaglione, Immacolata, Picariello, Stefania, Marcon, Alessia, Sturiale, Patrizia, Roberti, Domenico, Ivan Lazzarino, Antonio, Perrotta, Silverio, Casale, M, Forni, G, Cassinerio, E, Pasquali, D, Origa, R, Serra, M, Campisi, S, Peluso, A, Renni, R, Cattoni, A, De Michele, E, Allò, M, Poggi, M, Ferrara, F, Di Concilio, R, Sportelli, F, Quarta, A, Putti, M, Notarangelo, L, Sau, A, Ladogana, S, Tartaglione, I, Picariello, S, Marcon, A, Sturiale, P, Roberti, D, Lazzarino, A, and Perrotta, S

Subjects
medicine.medical_specialty, Iron Overload, Thalassemia, blood transfusion, Iron Chelating Agents, Benzoates, Risk Assessment, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Risk Factors, Internal medicine, Medicine, Endocrine system, Humans, Chelation therapy, iron chelation, business.industry, Incidence (epidemiology), Deferasirox, beta-Thalassemia, Hematology, Triazoles, medicine.disease, Chelation Therapy, 030220 oncology & carcinogenesis, Cohort, business, Complication, Thalassemia, endocrine complications, iron chelation, deferasirox, endocrine function, 030215 immunology, medicine.drug, Follow-Up Studies
Abstract

Transfusion-dependent patients typically develop iron-induced cardiomyopathy, liver disease, and endocrine complications. We aimed to estimate the incidence of endocrine disorders in transfusiondependent thalassemia (TDT) patients during long-term iron-chelation therapy with deferasirox (DFX). We developed a multi-center follow-up study of 426 TDT patients treated with once-daily DFX for a median duration of 8 years, up to 18.5 years. At baseline, 118, 121, and 187 patients had 0, 1, or ≥2 endocrine diseases respectively. 104 additional endocrine diseases were developed during the follow-up. The overall risk of developing a new endocrine complication within 5 years was 9.7% (95% Confidence Interval [CI]: 6.3–13.1). Multiple Cox regression analysis identified three key predictors: age showed a positive log-linear effect (adjusted hazard ratio [HR] for 50% increase 1.2, 95% CI: 1.1–1.3, P=0.005), the serum concentration of thyrotropin showed a positive linear effect (adjusted HR for 1 mIU/L increase 1.3, 95% CI: 1.1–1.4, P

Published
2020

5. White matter volume changes in adult beta‐thalassemia: Negligible and unrelated to anemia and cognitive performances

Author

Sara Ponticorvo, Mario Cirillo, Andrea G. Russo, Federica Ammendola, Renzo Manara, Rosanna Di Concilio, Silverio Perrotta, Andrea Elefante, Francesco Di Salle, Domenico Roberti, Angela Ciancio, Martina Caiazza, Pasquale Alessandro Carafa, Antonietta Canna, Maddalena Casale, Elisa De Michele, Immacolata Tartaglione, Fabrizio Esposito, Manara, Renzo, Canna, Antonietta, Caiazza, Martina, Ponticorvo, Sara, Russo, Andrea G, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Carafa, Pasquale Alessandro, Ammendola, Federica, Roberti, Domenico, Casale, Maddalena, Elefante, Andrea, Cirillo, Mario, Di Salle, Francesco, Esposito, Fabrizio, Perrotta, Silverio, Tartaglione, Immacolata, Manara, R., Canna, A., Caiazza, M., Ponticorvo, S., Russo, A. G., Di Concilio, R., Ciancio, A., De Michele, E., Carafa, P. A., Ammendola, F., Roberti, D., Casale, M., Elefante, A., Cirillo, M., Di Salle, F., Esposito, F., Perrotta, S., and Tartaglione, I.

Subjects
Adult, Anemia, business.industry, beta-Thalassemia, Physiology, Beta thalassemia, Cognition, Syndrome, Anemia, Sickle Cell, Hematology, medicine.disease, White Matter, White matter, medicine.anatomical_structure, Volume (thermodynamics), medicine, business, Human
Published
2020
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6. No evidence of increased cerebrovascular involvement in adult neurologically-asymptomatic β-Thalassaemia. A multicentre multimodal magnetic resonance study

Author

Gianluca Femina, Antonietta Canna, Sara Ponticorvo, Renzo Manara, Violetta Caserta, Maddalena Casale, Paolo Gritti, Elisa De Michele, Silverio Perrotta, Andrea G. Russo, Teresa Ferrantino, Camilla Russo, Martina Caiazza, Mario Cirillo, Giovanni Amendola, Antonella Centanni, Noemi Ippolito, Fabrizio Esposito, Angela Ciancio, Rosanna Di Concilio, Andrea Elefante, Ilaria Granato, Mario Ermani, Tiziana Oliveto, Pasquale Alessandro Carafa, Immacolata Tartaglione, Tartaglione, Immacolata, Russo, Camilla, Elefante, Andrea, Caiazza, Martina, Casale, Maddalena, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Amendola, Giovanni, Gritti, Paolo, Carafa, Pasquale A, Ferrantino, Teresa, Centanni, Antonella, Ippolito, Noemi, Caserta, Violetta, Oliveto, Tiziana, Granato, Ilaria, Femina, Gianluca, Esposito, Fabrizio, Ponticorvo, Sara, Russo, Andrea G, Canna, Antonietta, Ermani, Mario, Cirillo, Mario, Perrotta, Silverio, Manara, Renzo, Tartaglione, I., Russo, C., Elefante, A., Caiazza, M., Casale, M., Di Concilio, R., Ciancio, A., De Michele, E., Amendola, G., Gritti, P., Carafa, P. A., Ferrantino, T., Centanni, A., Ippolito, N., Caserta, V., Oliveto, T., Granato, I., Femina, G., Esposito, F., Ponticorvo, S., Russo, A. G., Canna, A., Ermani, M., Cirillo, M., Perrotta, S., and Manara, R.

Subjects
Adult, medicine.medical_specialty, brain MRI, Adolescent, transfusion medicine, Venography, thalassaemia, Asymptomatic, Magnetic resonance angiography, Brain Ischemia, White matter, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Leukoencephalopathies, medicine, Humans, thrombosi, Prospective Studies, vascular malformations, thrombosis, Aged, medicine.diagnostic_test, business.industry, beta-Thalassemia, Brain, Intracranial Aneurysm, Magnetic resonance imaging, Intracranial Artery, Hematology, Middle Aged, medicine.disease, Magnetic Resonance Imaging, White Matter, Thrombosis, Hyperintensity, medicine.anatomical_structure, Case-Control Studies, 030220 oncology & carcinogenesis, Radiology, Nervous System Diseases, medicine.symptom, business, Magnetic Resonance Angiography, 030215 immunology
Abstract

Multi-factorial causes jeopardize brain integrity in β-thalassaemia. Intracranial parenchymal and vascular changes have been reported among young β-thalassaemia patients but conventional magnetic resonance imaging (MRI) findings are contradictory making early MRI and magnetic resonance angiography (MRA)/venography monitoring a matter of debate. This study prospectively investigated 75 neurologically asymptomatic β-thalassaemia patients (mean-age 35·2±10·7years; 52/75 transfusion-dependent; 41/75 splenectomised) using a 3T magnetic resonance scanner; clinical, laboratory and treatment data were also collected. White matter ischaemic-like abnormalities, intracranial artery stenoses, aneurysms and sinus venous thrombosis were compared between patients and 56 healthy controls (mean-age 33·9±10·8years). No patient or control showed silent territorial or lacunar strokes, intracranial artery stenoses or signs of sinus thrombosis. White matter lesions were found both in patients (35/75, 46·7%) and controls (28/56, 50·0%), without differences in terms of number (4·0±10·6 vs. 4·6±9·1, P=0·63), size and Fazekas' Score. Intracranial aneurysms did not differ between patients and controls for incidence rate (7/75, 9·3% vs. 5/56, 8·9%), size and site. Vascular and parenchymal abnormality rate did not differ according to treatments or clinical phenotype. According to this study, asymptomatic β-thalassaemia patients treated according to current guidelines do not seem to carry an increased risk of brain and intracranial vascular changes, thus weakening recommendations for regular brain MRI monitoring.

Published
2019

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