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Las organizaciones en el mundo y a nivel local enfrentan el gran reto de llevar a cabo acciones encaminadas al cuidado y bienestar de los colaboradores a fin de mejor los índices de productividad y calidad de vida laboral, por ello las acciones de prevención de enfermedades laborales son, entre muchos, el eje central para el fomento de actividades que transformen a las empresas a través de la gestión de lugares seguros, actividades de trabajo pertinentes para los trabajadores y que faciliten el control de los factores de riesgos que puedan contribuir a su aparición en las mismas. Por tanto, este documento de informe de consultoría resume, el qué hacer y paso a paso para realizar la mejora de la implementación de la NTC ISO 45001:2018 en una empresa de 1 a 11 colaboradores. Organizations in the world and at the local level face the great challenge of carrying out actions aimed at the care and well-being of employees in order to improve productivity rates and quality of working life, therefore the actions for the prevention of occupational diseases are, among many, the central axis for the promotion of activities that transform companies through the management of safe places, relevant work activities for workers and that facilitate the control of risk factors that may contribute to their appearance in the same. Therefore, this consulting report document summarizes what to do and step by step to improve the implementation of NTC ISO 45001:2018 in a company with 1 to 11 employees. Especialista en Seguridad y Salud en el Trabajo http://www.ustabuca.edu.co/ustabmanga/presentacion Especialización

Parkinson’s disease; Non-motor symptoms; Sex Malaltia de Parkinson Símptomes no motors; Sexe Enfermedad de Parkinson; Síntomas no motores; Sexo Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed. COPPADIS and the present study were developed with the help of Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético ( https://fundaciondegen.org/) and Alpha Bioresearch (www.alphabioresearch.com). Also, we received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017–2020 por el proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”) to develop a part of the COPPADIS project.

Esta investigación analizó el valor de las actividades auditivas implementadas por profesores de inglés para mejorar la comprensión auditiva. La comprensión es crucial para la producción, podemos producir idioma oral y escrito cuando entendemos las entradas del idioma percibidas. Los profesores deben identificar la importancia que tienen sus actividades de enseñanza y recursos en el proceso de aprendizaje de sus estudiantes, ya que cada pequeño cambio que ellos hacen cuenta en el resultado. Se sabe que no es una tarea fácil identificar las metodologías apropiadas, es por esta razón que nos apegamos en la perspectiva de los profesores para identificar actividades de comprensión auditivas que pueden ser efectivas. El desarrollo de la presente investigación utilizó un enfoque cualitativo y entrevista-investigación lo que nos permitió describir la evidencia obtenida a través de una entrevista semi estructurada. Además, para obtener evidencia utilizamos transcripciones de las entrevistas y procesamos la información a través de categorización temática.

RESUMEN Introducción: El situs inversus totalis es una malformación congénita rara, caracterizado por una posición invertida de los órganos torácicos y abdominales, influyendo negativamente en la aproximación diagnóstica y en el tratamiento quirúrgico. Reporte: Se diagnosticó apendicitis aguda en un paciente varón de 28 años que conocía su anormalidad anatómica y se corroboró con imágenes tomográficas y la exploración laparoscópica. Ingresó a emergencia con 30 horas de dolor abdominal con inicio en epigastrio y posterior irradiación hacia la fosa iliaca izquierda. La tomografía confirmó su condición de situs inversus totalis y signos patológicos en la apendicitis localizada en FII; se realizó la intervención por laparoscopia sin complicaciones. Discusión: En pacientes con dolor en el cuadrante inferior izquierdo es importante un adecuado diagnóstico diferencial y el conocimiento previo de una anormalidad anatómica comunicada oportunamente hace viable un diagnóstico adecuado y una resolución quirúrgica exitosa. ABSTRACT Introduction: Situs inversus totalis is a rare congenital malformation, characterized by an inverted position of the thoracic and abdominal organs, negatively influencing the diagnostic approach and surgical treatment. Report: Acute appendicitis was diagnosed in a 28-year-old male patient who knew his anatomical abnormality and was corroborated with tomographic images and laparoscopic exploration. He was admitted to the emergency room with 30 hours of abdominal pain with onset in the epigastrium and subsequent radiation to the left iliac fossa. The tomography confirmed his condition of situs inversus totalis and pathological signs in localized appendicitis in FII; The laparoscopic intervention was performed without complications. Discusions: In patients with pain in the left lower quadrant, an adequate differential diagnosis is important and prior knowledge of an anatomical abnormality communicated in a timely manner, that makes feasible an adequate diagnosis and successful surgical resolution.

Funder: Funder: Calgary Laboratory Services (research support fund) Grant reference number: RS19-612, Funder: Funder: National Cancer Institute: National Institutes of Health Grant reference number: R01CA172404, BACKGROUND: Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed to translate prognostic mRNA markers into protein expression assays by immunohistochemistry and validate their survival association in HGSC. METHODS: Two prognostic genes, FOXJ1 and GMNN, were selected based on high-quality antibodies, correlation with protein expression and variation in immunohistochemical scores in a preliminary cohort (n = 134 and n = 80, respectively). Six thousand four hundred and thirty-four (FOXJ1) and 5470 (GMNN) formalin-fixed, paraffin-embedded ovarian neoplasms (4634 and 4185 HGSC, respectively) represented on tissue microarrays from the Ovarian Tumor Tissue Analysis consortium underwent immunohistochemical staining and scoring, then univariate and multivariate survival analysis. RESULTS: Consistent with mRNA, FOXJ1 protein expression exhibited a linear, increasing association with improved overall survival in HGSC patients. Women with >50% expression had the most favourable outcomes (HR = 0.78, 95% CI 0.67-0.91, p < 0.0001). GMNN protein expression was not significantly associated with overall HSGC patient survival. However, HGSCs with >35% GMNN expression showed a trend for better outcomes, though this was not significant. CONCLUSION: We provide foundational evidence for the prognostic value of FOXJ1 in HGSC, validating the prior mRNA-based prognostic association by immunohistochemistry.

Two human proteins involved in the inflammatory cell death, namely Gasdermin D (GSDMD) and the Mixed Lineage Kinase Domain-Like (MLKL) protein have been engineered to accommodate an efficient ligand of the tumoral cell marker CXCR4, and a set of additional peptide agents that allow their spontaneous self-assembling. Upon production in bacterial cells and further purification, both proteins organized as stable nanoparticles of 46 and 54 nm respectively, that show, in this form, a moderate but dose-dependent cytotoxicity in cell culture. In vivo, and when administered in mouse models of colorectal cancer through repeated doses, the nanoscale forms of tumor-targeted GSDMD and, at a lesser extent, of MLKL promoted CD8+ and CD20+ lymphocyte infiltration in the tumor and an important reduction of tumor size, in absence of systemic toxicity. The potential of these novel pharmacological agents as anticancer drugs is discussed in the context of synergistic approaches to more effective cancer treatments.

Ferromagnets generate an anomalous Hall effect even without the presence of a magnetic field, something that conventional antiferromagnets cannot replicate but noncollinear antiferromagnets can. The anomalous Hall effect governed by the resistivity tensor plays a crucial role in determining the presence of time reversal symmetry and the topology present in the system. In this work we reveal the complex origin of the anomalous Hall effect arising in noncollinear antiferromagnets by performing Hall measurements with fields applied in selected directions in space with respect to the crystalline axes. Our coplanar magnetic field geometry goes beyond the conventional perpendicular field geometry used for ferromagnets and allows us to suppress any magnetic dipole contribution. It allows us to map the in-plane anomalous Hall contribution and we demonstrate a 120$^\circ$ symmetry which we find to be governed by the octupole moment at high fields. At low fields we subsequently discover a surprising topological Hall-like signature and, from a combination of theoretical techniques, we show that the spins can be recast into dipole, emergent octupole and noncoplanar effective magnetic moments. These co-existing orders enable magnetization dynamics unachievable in either ferromagnetic or conventional collinear antiferromagnetic materials.

The Roux-en-Y gastric bypass is one of the most extensive surgical treatments for obesity. The treatment of upper gastrointestinal bleeding after Roux-en-Y gastric bypass is complex due to the difficulty of accessing the excluded gastric antrum and duodenal bulb. There is no consensus regarding the management of this complication. While various techniques have been described to access the biliopancreatic limb, double-balloon enteroscopy is the most commonly used. If double-balloon enteroscopy is unavailable, a pediatric colonoscope may be used as an alternative; however, its use in such cases has not been described. We report the case of a 50-year-old male patient who underwent gastric bypass 13 years ago and was admitted for a second episode of upper gastrointestinal bleeding. The initial approach using upper endoscopy, colonoscopy, and abdominal computed tomography angiography did not reveal the cause of gastrointestinal hemorrhage; therefore, an endoscopic study of the biliopancreatic limb was performed using a pediatric colonoscope. A Forrest Ib ulcer was found in the duodenal bulb, and endoscopic therapy was administered. The evolution was found to be satisfactory.

Graph Isomorphism is such an important problem in computer science, that it has been widely studied over the last decades. It is well known that it belongs to NP class, but is not NP-complete. It is thought to be of comparable difficulty to integer factorisation. The best known proved algorithm to solve this problem in general, was proposed by László Babai and Eugene Luks in 1983. Recently, there has been some research in the topic by using quantum computing, that also leads the present piece of research. In fact, we present a quantum computing algorithm that defines an invariant over Graph Isomorphism characterisation. This quantum algorithm is able to distinguish more non-isomorphic graphs than most of the known invariants so far. The proof of correctness and some hints illustrating the extent and reason of the improvement are also included in this paper.

Results of the whole-genome sequencing assembly and annotation of a rare actinomycete strain of genus Gordonia.

[Background and Objective] Caregiver burden in Parkinson's disease (PD) has been studied in many cross-sectional studies but poorly in longitudinal ones. The aim of the present study was to analyze the change in burden, strain, mood, and quality of life (QoL) after a 2-year follow-up in a cohort of caregivers of patients with PD and also to identify predictors of these changes., [Patients and Methods] PD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers of Spain from the COPPADIS cohort were included in the study. They were evaluated again at 2-year follow-up. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), and EUROHIS-QOL 8-item index (EUROHIS-QOL8) at baseline (V0) and at 2-year follow-up (V2). General linear model repeated measure and lineal regression models were applied., [Results] Significant changes, indicating an impairment, were detected on the total score of the ZCBI (p < 0.0001), CSI (p < 0.0001), BDI-II (p = 0.024), and EUROHIS-QOL8 (p = 0.002) in 192 PD caregivers (58.82 ± 11.71 years old; 69.3% were females). Mood impairment (BDI-II; β = 0.652; p < 0.0001) in patients from V0 to V2 was the strongest factor associated with caregiver's mood impairment after the 2-year follow-up. Caregiver's mood impairment was the strongest factor associated with an increase from V0 to V2 on the total score of the ZCBI (β = 0.416; p < 0.0001), CSI (β = 0.277; p = 0.001), and EUROHIS-QOL (β = 0.397; p = 0.002)., [Conclusion] Burden, strain, mood, and QoL were impaired in caregivers of PD patients after a 2-year follow-up. Mood changes in both the patient and the caregiver are key aspects related to caregiver burden increase., Santos García D. has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Lundbeck, KRKA, Zambon, Bial, Italfarmaco, and Teva. De Deus Fonticoba T.: None. Cores Bartolomé C. has received honoraria for educational presentations and advice service by Lundbeck and UCB Pharma. Íñiguez Alvarado MC: None. Feal Painceiras M. J.: None. Martínez Miró C.: None. Suárez Castro E.: None. Canfield H.: None. Jesús S. has received honoraria from AbbVie, Bial, Merz, UCB, and Zambon and holds the competitive contract “Juan Rodés” supported by the Instituto de Salud Carlos III. She has received grants from the Spanish Ministry of Economy and Competitiveness (PI18/01898) and the Consejería de Salud de la Junta de Andalucía (PI-0459-2018). Aguilar M.: UCB and Schwabe with assistance to a Congress; Nutricia with assistance to a Congress and payment of lecture. Pastor P.: None. Planellas LL.: None. Cosgaya M.: None. García Caldentey J. has received honoraria for educational presentations and advice service by Qualigen, Nutricia, Abbvie, Italfarmaco, UCB Pharma, Lundbeck, Zambon, Bial, and Teva. Caballol N. has received honoraria from Bial, Italfármaco, Qualigen, Zambon, UCB, Teva and KRKA and sponsorship from Zambon, TEVA and Abbvie for attending medical conferences. Legarda I. has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Zambon, Bial, and Teva. Hernández Vara J. has received travel bursaries and educational grants from Abbvie and has received honoraria for educational presentations from Abbvie, Teva, Bial, Zambon, Italfarmaco, and Sanofi-Genzyme. Cabo I. has received honoraria for educational presentations and advice service by Abbvie, Zambon, and Bial. López Manzanares L.: Compensated advisory services, consulting, research grant support, or speaker honoraria: AbbVie, Acorda, Bial, Intec Pharma, Italfarmaco, Pfizer, Roche, Teva, UCB, and Zambon. González Aramburu I.: None. Ávila Rivera MA. has received honoraria from Zambon, UCB Pharma, Qualigen, Bial, and Teva, and sponsorship from Zambon and Teva for attending conferences. Gómez Mayordomo V.: None. Nogueira V.: None. Puente V. has served as consultant for Abbvie and Zambon; has received grant/research from Abbvie. Dotor García-Soto J.: Compensated advisory services, consulting, research grant support, or speaker honoraria: Merck, Sanofi-Genzyme, Allergan, Biogen, Roche, UCB and Novartis. Borrué C.: None. Solano Vila B. has received honoraria for educational presentations and advice service by UCB, Zambon, Teva, Abbvie, Bial. Álvarez Sauco M. has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Zambon, Bial, and Teva. Vela L. has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Lundbeck, KRKA, Zambon, Bial, and Teva. Escalante S. has received honoraria for educational presentations and advice service by Abbvie, Zambon, and Bial. Cubo E.: Travel grants: Abbvie, Allergan, Boston; Lecturing honoraria: Abbvie, International Parkinson's disease Movement Disorder Society. Carrillo Padilla F. has received honoraria from Zambon (SEN Congress assistance). Martínez Castrillo JC. has received research support from Lundbeck, Italfarmaco, Allergan, Zambon, Merz, and Abbvie. He has received speaking honoraria from AbbVie, Bial, Italfarmaco, Lundbeck, Krka, TEVA, UCB, Zambon, Allergan, Ipsen, and Merz. Sánchez Alonso P. has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Lundbeck, KRKA, Zambon, Bial, and Teva. Alonso Losada M. G. has received honoraria for educational presentations and advice service by Zambon and Bial. López Ariztegui N. has received honoraria for educational presentations and advice service by Abbvie, Italfarmaco, Zambon, and Bial. Gastón I. has received research support from Abbvie and Zambon and has served as a consultant for Abbvie, Exelts, and Zambon. Kulisevsky J.: (1) Consulting fees: Roche, Zambon; (2) Stock/allotment: No; (3) Patent royalties/licensing fees: No; (4) Honoraria (e.g. lecture fees): Zambon, Teva, Bial, UCB; (5) Fees for promotional materials: No; (6) Research funding: Roche, Zambon, Ciberned; Instituto de Salud Carlos III; FundacióLa Maratóde TV3; (7) Scholarship from corporation: No; (8) Corporate laboratory funding: No; (9) Others (e.g., trips, travel, or gifts): No. Blázquez Estrada M. has received honoraria for educational presentations and advice service by Abbvie, Abbott, UCB Pharma, Allergan, Zambon, Bial, and Qualigen. Seijo M. has received honoraria for educational services from KRKA, UCB, Zambon, Bial; travel grants from Daiichi and Roche. Ruiz Martínez J. has received honoraria for educational presentations, attending medical conferences, and advice service by Abbvie, UCB Pharma, Zambon, Italfarmaco, Bial, and Teva. Valero C. has received honoraria for educational services from Zambon, Abbvie and UCB. Kurtis M. has received honoraria from Bial, the Spanish Neurology Society, and the International and Movement Disorders Society. de Fábregues O. has received honoraria for educational presentations and advice service by Bial, Zambon, Abbvie, KRKA, and Teva. González Ardura J. has received honoraria for speking from italofarma, Krka, Genzyme, UCB, Esteve, Psyma iberica marketing research SL and Ferrer, course grant from Teva and travel grant from Merck. Alonso Redondo R.: None. Ordás C.: None. López Díaz L. M. has received honoraria from UCB, Lundbeck, and KRKA. McAfee D.: None. Martínez-Martin P. has received honoraria from National School of Public Health (ISCIII), Editorial Viguera and Takeda Pharmaceuticals for lecturing in courses, and from the International Parkinson and Movement Disorder Society (MDS) for management of the Program on Rating Scales. Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB, and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [ PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.

Ultrafast laser pulses provide unique tools to manipulate magnetization dynamics at femtosecond timescales, where the interaction of the electric field -- such as excitation of spin carriers to non-equilibrium states, generation of localized charge currents, demagnetization, or inverse Faraday effect -- dominates over the magnetic field. Recent proposals using structured laser beams have enlightened the possibility to generate intense femtosecond magnetic fields, spatially isolated from the electric field. Here we demonstrate the relevance of this novel scenario to femtomagnetism, unveiling the purely precessional, non-linear, chiral response of the magnetization when subjected to circularly polarized magnetic fields. This fundamental result not only opens an avenue in the study of laser-induced ultrafast magnetization dynamics, but also sustains technological implications as a route to promote all-optical non-thermal magnetization switching both at shorter timescales -- towards the attosecond regime -- and at THz frequencies.

Additional file 1. Additional tables and figures.

[Background] Motor phenotype (MP) can be associated with a different prognosis in Parkinson's disease (PD), but it is not fixed and can change over time., [Objective] Our aim was to analyze how the MP changed over time and to identify factors associated with the changes in PD patients from a multicenter Spanish PD cohort., [Methods] PD patients who were recruited from January-2016 to November-2017 (baseline visit; V0) and evaluated again at a 2-year±30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this study.MP was calculated at both visits based on Jankovic classification in TD (tremor dominant), IND (indeterminate), or PIGD (postural instability and gait difficulty). Sociodemographic and clinical data were collected, including serum biomarkers., [Results] Five hundred eleven patients (62.57±8.59 years old; 59.2%males) were included in the study. At V0, MP was: 47.4%(242/511) TD; 36.6%(187/511) PIGD; 16%(82/511) IND. Up to 38%(194/511) of the patients changed their phenotype from V0 to V2, being the most frequent from TD to IND (8.4%) and from TD to PIGD (6.7%). A worse cognitive status (OR = 0.966) and less autonomy for activities of daily living (OR = 0.937) at V0 and a greater increase in the globalNMS burden (OR = 1.011) from V0 to V2 were associated with changing from TD to another phenotype after 2-year follow-up., [Conclusion] The MP in PD can change over time. With disease progression, the percentage of cases with non-tremoric MP increases. PD patients who changed from TD to postural instability and gait difficulty increased NMS burden significantly.

La presente investigación descriptiva propositiva tiene como objetivo diseñar una propuesta de un modelo articulado de los programas Juntos y Beca 18, para contribuir a la capitalización del recurso humano awajun de Santa María de Nieva – Amazonas, para lograrlo se aplicó un cuestionario de 20 ítems, con un nivel de validez y confiabilidad de 0.83, a 148 beneficiarios del Programa Juntos, que el año 2020 egresaron concluyendo la educación secundaria. Para la presentación, análisis e interpretación de los resultados se utilizó la estadística descriptiva e inferencial, particularmente el programa SPSS V. 26. A partir de la información recogida se concluyó que, el 62.2% de egresados del referido programa alcanzaron el nivel inicio en el desarrollo de sus capacidades para afrontar la vida con éxito y romper la transmisión intergeneracional de la pobreza y pobreza extrema; el restante (37,8%) se encuentra en proceso. Teniendo en consideración los resultados antes descritos y postulados de las teorías del cambio, del capital humano y la teoría intercultural, se diseñó la propuesta de un modelo articulado de los programas Juntos y Beca 18, para capitalizar el recurso humano awajun, la misma que fue validada a través de juicio de expertos, quedando expedito para ser aplicado. Chiclayo Escuela de Posgrado Reformas y Modernización del Estado Biodiversidad, cambio climático y calidad ambiental Apoyo a la reducción de brechas y carencias en la educación en todos sus niveles Fin de la pobreza

El projecte RESCITIES “L’ecologia política de la resiliència urbana als fenòmens hidro-climàtics a Espanya”, és un projecte de recerca coordinat per la UOC i finançat per la Agencia Estatal de Investigación (PGC2018-100996-AI00(MCIU/AEI/FEDER, UE). En el projecte ha participat activament personal investigador d’altres universitats incloent la Universitat de Sevilla. El projecte ha durat des del Gener de 2019 al Juny de 2022, i s’ha centrat en dues ciutats de l’estat, Barcelona i Sevilla, que s’enfronten a diferents riscos hidroclimàtics (onades de calor, sequeres, inundacions) en un context de canvi climàtic. El proyecto RESCITIES “La ecología política de la resiliencia urbana a los fenómenos hidro-climáticos en España”, es un proyecto de investigación coordinado por la UOC y financiado por la Agencia Estatal de Investigación (PGC2018-100996-AI00(MCIU/AEI/FEDER, UE). El proyecto se inició en enero de 2019 y se extendió hasta junio de 2022, centrándose en dos ciudades del estado, Barcelona y Sevilla, que se enfrentan a diferentes riesgos hidroclimáticos (olas de calor, sequías, inundaciones) en un contexto de cambio climático. El proyecto ha sido coordinado por la UOC en colaboración con investigadores de las universidades de Sevilla, Pablo de Olavide y Córdoba. The RESCITIES project "The political ecology of urban resilience to hydro-climatic phenomena in Spain", is a research project coordinated by the UOC and funded by the State Research Agency (PGC2018-100996-AI00(MCIU/AEI/FEDER, EU). The project began in January 2019 and lasted until June 2022, focusing on two cities in the state, Barcelona and Seville, which face different hydroclimatic risks (heat waves, droughts, floods) in a context of climate change. The project has been coordinated by the UOC in collaboration with researchers from the universities of Sevilla, Pablo de Olavide and Córdoba.

Introducción. Tras la necesidad docente de conseguir que los estudiantes aprendan paradigmas contrapuestos entre sí, se plantea el desarrollo de un juego de roles en el que se defienda un modelo específico frente a otro. Objetivos Este método busca integrar dos competencias. La primera, la resolución de problemas y la segunda, el trabajo en equipo. En el primer caso se espera que los estudiantes desarrollen la habilidad de responder a problemas planteados sin conocerlos con anterioridad y que para ello utilicen los medios técnicos de búsqueda de información. En el segundo, potenciar las habilidades de cada uno como valor positivo dentro del grupo. Metodología La práctica consiste en dividir el grupo en cuatro subgrupos. Tres de ellos adoptaran un modelo o paradigma sobre un tema determinado y que tengan puntos comunes y opuestos entre sí. Un cuarto equipo, al que le llamamos “conciencia crítica”, será el encargado de establecer las normas de debate, elaborar los problemas a defender y vigilar que ninguno salga del rol que le ha sido asignado. En el caso práctico que nos ocupa, se trabajan los tres modelos de Estado del Bienestar definidos por Esping-Andersen: socialdemócrata, conservador y liberal. Cada grupo deberá adoptar uno de los tres modelos y defender frente al resto que el suyo es el mejor para la España actual y rebatir los argumentos del resto. Par a preparación, los estudiantes deberán tener como mínimo dos sesiones de tutorías. En la primera de ellas se le explicarán el desarrollo de la práctica, las características básicas de su modelo y se le indicarán una serie lecturas que le sirvan de base para enfrentarse a los problemas. En el segundo se aclararán dudas y se afianzarán las líneas centrales de cada uno de los modelos. Para el caso del cuarto grupo, se revisarán los problemas que se plantean. Resultados En tanto los problemas a resolver son planteados por los propios estudiantes, el foco se acomoda a sus intereses y preocupaciones sobre los dilemas sociales y políticos que acontecen en su entorno. Así, en la experiencia desarrollada aparecen temas como la gestión urbana, el medio ambiente o el ocio, alejados de los típicamente tratados en la asignatura de referencia. Inmediatamente, se detecta una alta motivación y una percepción positiva del ejercicio por parte del alumnado. Conclusiones El juego de roles es un mecanismo que ha demostrado ser efectivo en el aprendizaje de modelos de explicación de cualquier tipo de realidad. El caso que aquí presentamos puede ser válido para el desarrollo de otros debates, como pueden ser, por ejemplo, distintos pensadores dentro de la sociología. El éxito definitivo de esta metodología radica sobre todo en el énfasis de que no se ha de adoptar una actitud competitiva o dicho de otro modo, al final del juego no habrá ganadores, no perdedores. Introduction. In response to the teaching need to have students learn contrasting paradigms, the development of a role-playing game where one defends a specific model against another is proposed. Objectives. This method seeks to integrate two competencies: problem-solving and teamwork. In the first case, students are expected to develop the ability to respond to previously unknown problems and utilise technical means of information search. In the second case, the goal is to enhance each individual's skills as a positive value within the group. Methodology. The practice involves dividing the group into four subgroups. Three will adopt a model or paradigm on a specific topic, highlighting common and opposing points. The fourth team, called the "critical consciousness," will establish debate rules, formulate the problems to defend, and ensure that none deviates from their assigned role. In the specific case at hand, the three models of the Welfare State defined by Esping-Andersen will be examined: social democratic, conservative, and liberal. Each group must adopt one of the three models and argue that theirs is the best for contemporary Spain, while refuting the arguments of the other groups. To prepare, students should have a minimum of two tutorial sessions. In the first session, they will be briefed on the practice's development and the essential characteristics of their chosen model and provided with relevant readings for addressing the problems. The second session will address any doubts and consolidate the central lines of each model. For the fourth group, the issues they will pose will be reviewed. Results. As the students propose solving the problems, the focus adjusts to their interests and concerns regarding social and political dilemmas in their environment. Thus, the experience encompasses urban management, the environment, or leisure, typically outside the reference subject. Immediately, a high level of motivation and a positive perception of the exercise are observed among the students. Conclusions. The role-playing game is a proven effective mechanism for learning explanatory models of any reality. The case presented here can be valid for developing other debates, such as different sociology thinkers. The ultimate success of this methodology lies primarily in emphasizing that a competitive attitude should be kept from adopting. In other words, there will be no winners or losers at the end of the game.

Las enfermedades cardiovasculares, encabezadas por el infarto agudo de miocardio (IAM), son la causa más frecuente de muerte e incapacidad a nivel global y en nuestro entorno. Las bases etiológicas del IAM son complejas e intervienen tanto factores ambientales como hereditarios. La constante evolución de las redes asistenciales y los nuevos tratamientos han mejorado la supervivencia inicial del IAM, pero el riesgo de recurrencias y de complicaciones a largo plazo como la insuficiencia cardiaca continúa siendo elevado. Como determinantes genéticos de riesgo de IAM se han identificado decenas de polimorfismos de un solo nucleótido (SNPs), cada uno de los cuales asocia un pequeño incremento del riesgo. Así, para la realización de una estimación global, se han desarrollado escalas de riesgo poligénico (GRS) integradas por múltiples SNPs. Hasta ahora, los GRS habían sido evaluados en la población general, pero su utilidad entre pacientes que ya han sufrido un IAM es en gran medida desconocida. Como reguladores altamente específicos de la expresión génica, los microRNAs (miRNAs) están emergiendo como nuevos biomarcadores, habiendo sido identificados como actores clave en el desarrollo de enfermedades. La presente Tesis Doctoral aborda como objetivo general caracterizar la utilidad de estas dos familias de reguladores génicos en el IAM: SNPs y miRNAs, como biomarcadores con finalidad pronóstica a largo plazo en pacientes con IAM, así como analizar la potencial implicación de los miRNAs en el daño miocárdico crónico tras IAM, y por tanto, su capacidad para constituirse como nuevas dianas terapéuticas. En primer lugar, dado que la prevalencia de variantes genéticas de riesgo en población joven no diabética que presenta un IAM es superior a la de la población general, se planteó un estudio clínico prospectivo en una cohorte de 81 pacientes con IAM y elevada susceptibilidad hereditaria. Dicho estudio nos ha permitido documentar que el perfil genético evaluado con un GRS basado en 11 SNPs está asociado con una mayor probabilidad de eventos cardiovasculares recurrentes futuros, incrementando el rendimiento de los algoritmos de estratificación pronóstica tras IAM. Sucesivamente, se puso en marcha un ambicioso programa de identificación y validación de miRNAs en IAM para su utilización en práctica clínica. Para ello se planteó un estudio clínico prospectivo en una cohorte general de 311 pacientes con IAM con seguimiento a largo plazo, se estableció una cohorte de control con población sana y se realizaron varios modelos experimentales in vivo e in vitro. El estudio clínico nos ha permitido identificar, de forma inédita, una combinación de miRNAs desregulados en IAM con capacidad de constituirse en biomarcadores con utilidad pronóstica. De forma destacada, miR-21-5p, miR-23a-3p, miR-27b-3p, miR-122-5p, miR-210-3p y miR-221-3p fueron capaces de identificar a pacientes con mayor riesgo de desarrollo de insuficiencia cardiaca y mortalidad cardiovascular a largo plazo tras IAM. La información proporcionada por estos miRNAs fue independiente y adicional a ofrecida por las variables clínicas, mejorando todas las estrategias de predicción de riesgo actuales. Adicionalmente, los hallazgos de los modelos experimentales in vivo de oclusión coronaria permanente e isquemia reperfusión en ratas, así como los modelos in vitro en cardiomiocitos H9c2, correlacionaron con los resultados obtenidos en pacientes, validando estos modelos experimentales para el estudio de las bases génicas y moleculares por las que los miRNAs ejercen el papel regulador que les dota de utilidad pronóstica. Finalmente, la modulación exógena en cardiomiocitos de dos de los miRNAs más prometedores (miR-210-3p y miR-23a-3p) indujo cambios en la expresión en varios genes fundamentales para el proceso de apoptosis y remodelado ventricular adverso tras IAM que pueden estar en relación con su capacidad pronóstica a nivel clínico. Para concluir, el estudio de biomarcadores génicos en el IAM ha permitido constatar la utilidad pronóstica de una escala de riesgo poligénico en pacientes con IAM. De forma destacada, el estudio de identificación y valoración pronóstica de miRNAs en pacientes con IAM realizado en el presente trabajo constituye un ejemplo de investigación traslacional bench to bedside en el que, partiendo de unos resultados prometedores en pacientes, se han podido explorar en modelos in vitro e in vivo los mecanismos que regulan la adaptación celular tras un daño isquémico agudo, y que pueden justificar su utilidad pronóstica. Así, el resultado de este trabajo evidencia la posible utilidad de estos biomarcadores génicos en la práctica clínica y permite sentar las bases para el desarrollo de potenciales tratamientos dirigidos en un futuro.

We investigate the role of morphodynamic changes in the flooding of a micro-tidal dissipative beach for both current and sea level rise scenarios. By considering beach morphodynamics and flood processes associated with highly energetic waves, the study allows one to evaluate threats to coastal zones. Coupling of SWAN and XBeach models is employed to propagate offshore wave conditions to the swash zone, estimating morphological changes and flooding associated with wave conditions during cold fronts and hurricanes that affected Cartagena de Indias (Colombia). The numerical models were calibrated from previous research in the study area. The results indicate that numerical modeling of flooding on microtidal dissipative beaches under extreme wave conditions should be approached by considering beach morphodynamics, because ignoring them can underestimate flooding by ∼ 15 %. Moreover, model results suggest that beach erosion and flooding are intensified by sea level rise, resulting in the most unfavorable condition when extreme events are contemporaneous with high tides. In this case, the increase in erosion and flooding is ∼ 69 % and ∼ 65 %, respectively, when compared with the present conditions of sea level.

Esta investigación se orienta a la construcción, desde la acción colectiva, de un currículo de Idioma Extranjero - inglés, que religa los principios del Enfoque Sociocrítico y la Pedagogía de Géneros Discursivos, de tal cuenta que se constituya en un entretejido dialógico tendiente al desarrollo de la capacidad de Agencia Humana en estudiantes y docentes de básica secundaria y media. En ese sentido, a partir de un primer acercamiento diagnóstico, se configura el contexto problémico que justifica ontológica y epistemológicamente la inserción investigativa. Seguidamente, se realiza una indagación georreferenciada de información empírica antecedente que estructura el Estado del Arte de las categorías objeto de estudio en el ámbito internacional, nacional y local y que evidencia como los entramados curriculares de idioma extranjero inglés se han anclado a una visión técnica y descontextualizada que asume a los individuos como ingenuos actores ejecutantes y no como agentes sentipensantes, dinámicos y promotores de transformación y cambio social. Articuladamente, se aborda una aproximación a los fundamentos teóricos que subyacen a las categorías de la investigación para finalmente, ilustrar la ruta metodológica que desde el paradigma sociocrítico y la óptica de la Investigación Acción-Participativa (IAP) se orienta al logro de los objetivos propuestos. De esta manera, se propone una visión del currículo de Idioma Extranjero – inglés como actividad consciente, creativa, contextualizada y comprometida con el entramado saber académico - saber cotidiano que resulta de un proceso de socioconstrucción, autoformación y transformación bio-antropo-sociológica de docentes y estudiantes y que los potencia como agentes para actuar deliberadamente guiados por propósitos y metas comunes. This research seeks to build, from the collective action, English as a Foreign Language curriculum, which combines the principles of the Sociocritical Approach and Genre Pedagogy, in such a way that it becomes a dialogic interweaving oriented to the development of the capacity of Human Agency in secondary and middle school. In this sense, from a first diagnostic approach, the problematic context that ontologically and epistemologically justifies the research insertion is configured. Next, a georeferenced inquiry of empirical background information that structures the State of the Art of the categories under study at the international, national, and local levels is carried out, which evidences how the curricular frameworks of the English foreign language have been anchored to a technical and decontextualized vision that assumes individuals as naïve executing actors and not as thinking, dynamic and promoting agents of transformation and social change. Articulately, an approach to the theoretical foundations that underlie the categories of the research is approached to finally illustrate the methodological route that from the sociocritical paradigm and the optics of the Participatory Action Research (PAR) is oriented to the achievement of the proposed objectives. In this way, it proposes a vision of the Foreign Language - English curriculum as a conscious, creative, contextualized and committed activity with the academic knowledge - everyday knowledge framework that results from a process of socio-construction, self-education and bio-anthropo-sociological transformation of teachers and students and that empowers them as agents to act deliberately guided by common purposes and goals.

Artículo de Luis A. Díaz para el libro El legado de Manuel Belgrano. Fil: Díaz, Luis A. Díaz, L. A. (2020). “Manuel Belgrano, el político revolucionario que la historiografía eligió no mirar”, en Universidad de la Defensa Nacional y Universidad de Lanús (eds.), El legado de Manuel Belgrano (pp. 43-79). Buenos Aires: Universidad de la Defensa Nacional.

Teaching and learning have been broadly modified due to the introduction of digital devices in the classroom, as well as Content and Integrated Learning methodologies applied. Digital and linguistic tools have been concurrently utilized to teach and learn subject contents. However, poor study has been developed upon informal contexts of CLIL learning through streaming platforms. Thus, this study is a continuation of an early contribution (Díaz- Luis, 2020) about language and content learning through digital audiovisual platforms. For this reason, an investigation has been conducted (n= 39) selecting private Secondary Education high school students to analyze how they learn English as a foreign language and subject content while they are watching audiovisual material online. A questionnaire has been created to investigate how the English language and disciplinary aspects are learned. The results have demonstrated that these informal practices have certain learning contributions to different disciplines being English the lingua franca in these digital platforms.

COPPADIS Study Group., [Background] Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials., [Methods] Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study., [Results] Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p, [Conclusions] We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD., Fundación Curemos el Parkinson (https://curemoselparkinson.org/) covered the expenses derived from hiring a CRO and from carrying out complementary tests.

Este trabajo presenta una metodología para la determinación de prioridades de investigación y su contextualización en un sistema territorial de salud. Se realizó una búsqueda de información sobre tendencias internacionales y nacionales, un análisis bibliométrico basado en co-ocurrencia de palabras, y se valoraron los pasos y herramientas a considerar en la propuesta a delinear. Las principales variables y sus relaciones se representaron en una red de co-ocurrencia que junto a los clusters y la cuantificación de la ocurrencia denotaron las etapas y los instrumentos más relevantes y, por ende, referentes para el diseño de la metodología. Se percibe que la priorización de la investigación es clave para definir políticas públicas, científicas o de ciencia, tecnología e innovación, para asignar recursos eficientemente y para diseñar planes de intervención. La metodología abarca estos preceptos y constituye un proceso sistemático de apoyo a la gestión de la ciencia y la innovación en salud.

Maestría en Educación y Desarrollo Humano, Facultad de Ciencias Sociales y Humanas. Esta investigación presenta la reflexión en torno a la pregunta por cómo se han configurado los empoderamientos pacifistas de las/os jóvenes en el Centro Cultural Mama – Ú, Quibdó, desde una perspectiva intercultural, cuya configuración representa prácticas de re-existencia comunitaria gestadas desde el territorio, co-habitado por las/os protagonistas de la experiencia. Estas prácticas constituyen otros modos de co-construir las paces en el mundo popular, por lo cual se entrelazan mecanismos de interpelación y reinvención a las condiciones de violencia directa, cultural y estructural, que atraviesan su dimensión inmaterial y material. La comprensión fue posible a la luz de un proceso de investigación cualitativo transitado con la hibridación metodológica del Método MARDIC y la Teoría Fundamentada para la generación de conocimiento situado; en esta medida se movilizó la ecología de saberes cotidianos, ancestrales y académicos, para tejer las categorías emergentes en el diálogo de las narrativas juveniles y la fundamentación teórico – conceptual. Por último, el proceso posibilitó la articulación de investigación y acción, con el diseño de un Programa Educativo Para el Agenciamiento Social – PEPAS, que puede desarrollarse en escenarios comunitarios y/o institucionales; este programa se basa en los hallazgos entretejidos en el análisis, la discusión y los resultados del estudio.

Arrhyton albicollum sp. nov. (Figs. 1–7) Holotype. MHNHCu 6000. Juvenile male. Entrance of Cueva de los Panaderos (21.105861, -76.138222, WGS84), Gibara, Holguín. Collected by Alexis Silva García and José Raúl Suárez Bauzá on the 7th of January 2010. Diagnosis. A species of the genus Arrhyton, related to A. redimitum, as shown in the molecular phylogeny of Fig. 3. It can be distinguished from other species of the genus by the combination of (1) a wide immaculate white neck band or collar; (2) faint body stripes on a gray to grayish-tan background; (3) a solidly black and sharply defined cephalic pattern (“cap”, sensu Schwartz 1965), surrounded by whitish gray; (4) a short and solidly pigmented dark stripe crossing the eye, interrupted posteriorly by the white neck band, (5) a mucronate rostral scale (see Discussion), (6) high number of ventral scales (145), and high number of subcaudal scales (132). Most Arrhyton species have basically three well-defined body stripes on a tan or brown background, but there is variation in this character and two additional paravertebral stripes may be present depending on the species, giving some taxa a quinquelineate pattern (Fig. 1B–H). Arrhyton albicollum sp. nov. is closely related to A. redimitum. Juveniles of A. redimitum may have a pair of small occipital spots interrupted by the middorsal stripe or show narrow post-occipital indentations of the paler colored areas on either side of the middorsal stripe that abruptly disconnect the paravertebral stripes from the cephalic pattern (Figs. 1B and 2B–D). The cephalic “cap” is dark brown, generally paler in the middle and outlined dark in adults. The dark stripe across the eye from the sides of snout is continuous with the lateral stripe on each side, running along the body to the tail. None of the available specimens of A. redimitum has a conical, abrupt, dark projection on the rostral scale. Like most A. redimitum, A. albicollum sp. nov. has a dark spot on each of the internasal scales and stippled first labials. The ventral scale count of A. albicollum sp. nov. (145) is within the range of A. redimitum. However, only the holotype (MCZ 42505) of A. landoi (= A. redimitum) has 150 ventrals, the remaining sampled individuals of this species have 110–144 (mean 128, n = 54) ventrals. The number of subcaudal scales of A. albicollum sp. nov. is higher than that of A. redimitum (63–125, mean 89, n = 44; specimens with missing tail tips were not included). Arrhyton dolichura (Figs. 1C and 2F), A. procerum (Figs. 1D and 2G), and A. tanyplectum (Figs. 1F and 2J, K), have long tails which are 40–46% of the TL versus 25–40% of the TL of other species (39% in A. albicollum sp. nov.). These snakes have well defined stripes, and usually a vivid yellow or cream coloration on the lower flanks and the belly. In none of them is the cephalic dorsal pattern or “cap” solid black (as in A. albicollum sp. nov.) and the number of subcaudal scales of A. albicollum sp. nov. is in the range of A. tanyplectum (Table 1). Arrhyton ainictum has a well-defined quinquelineate pattern, 137 ventrals (vs. 145 in A. albicollum sp. nov.), 108 subcaudals (versus 132), and shorter tail which is 33% of TL (vs. 39%). Arrhyton vittatum (Figs. 1G and 2L) is easily distinguished from A. albicollum sp. nov. and the other species of Arrhyton in that it has a reddish brown coloration. The middorsal stripe may be absent, paler, or wider than those stripes on the flanks. Intercalated paravertebral stripes are sometimes slightly evident or generally absent in this species. The ventral coloration is pearl-white to iridescent grayish-pink. Juveniles may have some evidence of small occipital pale spots; the dark cephalic dorsal pattern is diffuse in adults (“soot-like”), not conspicuously surrounded by a distinctive pale coloration, and the snout is mostly pale brown. The number of ventral (107–123) and subcaudal (52–81) scales is notably lower than A. albicollum sp. nov. (Table 1) and the tail is shorter, 29–33% TL (vs. 39%). Arrhyton supernum (Figs. 1E and 2H) has two occipital pale spots, instead of a broad white band, interrupted by the middorsal stripe; the overall coloration is dark brown, compared with the grayish color of A. albicollum sp. nov., the number of ventral (124–128) and subcaudal (107–108) scales is much lower (Table 1), and the tail is 26% TL (vs. 39%). Arrhyton taeniatum (Figs. 1H and 2I) is the largest species (up to 457 mm SVL, MNHNCu 4622) and it occurs syntopically with A. albicollum sp. nov. It is the only species which always lacks a loreal scale. It has wide body stripes that in some individuals are indistinct from the brown background, vivid yellow flanks and belly, the highest number of ventral scales (168–189, vs. 145 in A. albicollum sp. nov.), a projected and upturned rostral scale, a laterally expanded head and smaller eyes which are far from the head outline when seen dorsally vs. larger and slightly protruded eyes from the head outline in A. albicollum sp. nov. Description of holotype. See Fig. 4 for head scales. SVL 143.5 mm; Ta 90.5 mm (39% TL), 234 mm TL. Head distinct from body; head length 8.6 mm (6% SVL), head width 5.5 mm (64% head length) at widest point, head height 3.5 mm at tallest point; interocular distance 3.7 mm (67% head width); snout-eye distance 2.2 mm (25% head length, HL); nostril-eye distance 1.5 mm; rostral subtriangular, 1.9 mm wide and 1.2 mm high, well visible in dorsal view; prefrontal divided, 1.6 mm long (17% HL), 2.3 times longer than internasals; prefrontals not in contact with orbit, but instead contacting supraocular and upper half of the preocular; frontal subtriangular 2.5 mm long (29% HL) and 2.2 mm wide; supraocular 1.8 mm long (21% HL) and 0.9 mm wide, twice wider distally than proximally; parietals 3.4 mm long (39% HL), 2.4 mm wide; nasal divided; nostril horizontally oval, its posterior border lying on the nasal suture, but most of the opening is on the prenasal scale; prenasal scale 0.7 mm (8% HL); postnasal scale 0.6 mm (7% HL); loreal single, quadrangular, 0.6 mm long (7% HL) and 0.4 mm high; loreal contacting second supralabial; preocular single, two times higher than wide, entering orbit posteriorly; eye diameter 1.9 mm (22% HL), pupil round; postoculars 2/2, upper postocular twice higher than lower postocular; temporals 1+2+3 on both sides of head; supralabials 7/7, of which 3rd and 4th are in contact with the eye; 6th supralabial slightly tallest than 5th, both in contact with first temporal; infralabials 8/8, first pair in contact with mental, 1st to 3rd contacting first chinshields, 4th and 5th contacting second chinshields; dorsals smooth, rhomb shaped, with no pits externally visible; dorsal scales row formula 17–17–17; cloacal plate divided; number of ventral and subcaudal scales were already mentioned in the diagnosis; a terminal conical projection about five times longer than the two last subcaudals. Color in life (Fig. 1A): Dorsum gray to grayish-tan, with faint stripes. Each scale with somewhat darker pigmentation on the edge giving the overall dorsal region a net-like appearance. The neck band is immaculate white, and behind it there is a slightly darker, smoky-gray pigmentation that transitions to the dorsal color. Internasal scales with a dark spot on each. Another dark spot is present on each prenasal scale. First three supralabials and four infralabials stippled with dark brown. Rostral conical projection dark. Eye bicolored: upper half grayish-white; inferior half very dark brown, almost black. Venter paler than dorsum. A faint lateral stripe on scale row four, just defined by slightly darker pigmentation of scale borders, giving a serrated outline and bordered at the top by a narrow zone paler than the rest of the dorsum. Color in alcohol (ten years after collection): similar to coloration in life, except that yellowish pigments completely disappeared. The faint stripes are even less obvious. Distribution. Arrhyton albicollum sp. nov. is only known from the type locality near the town of Gibara, ~ 36 km NNE from the city of Holguín in eastern Cuba (Fig. 5), but it probably occurs in suitable habitats between Bahía de Puerto Padre and Banes (Las Tunas and Holguín Provinces, respectively). Habitat. The type specimen was found under a pile of rocks at the entrance of Cueva de los Panaderos during the day (Fig. 6). Caves and sinkholes are common structures in the area. The locality has patches of secondary semideciduous forest on limestone rock; however, the native vegetation is being displaced by the invasive spiny-bush Dichrostachys cinerea and the whole area is threatened by human use of caves and the trash dumping. Associated herpetofauna and complementary description of habitat is in Díaz et al. (2014). Etymology. The specific epithet is derived from the Latin words albus (white) and collum (neck), in reference to the conspicuous white neck band. Proposed English name. Gibara White-collared Racerlet

Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab &amp, England Activities of Daily Living Scale (S&amp, E-ADLS) at V0 and V2. FD was defined as an S&amp, E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&amp, E-ADLS score from V0 to V2 (N = 507, from 88.58 ± 10.19 to 84.26 ± 13.38, p &lt, 0.0001, Cohen’s effect size = −0.519) was observed but not in controls (N = 124, from 98.87 ± 6.52 to 99.52 ± 2.15, p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908, p = 0.009), have longer disease duration (OR = 1.152, p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574, p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244, 0.0001) and BDI-II (OR = 1.080, p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963, p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168, p = 0.0.29), FOGQ (OR = 1.348, 0.0001) and VAFS-Mental (OR = 1.177, p = 0.013) (adjusted R-squared 0.52, Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.

Background: Acute-on-chronic liver failure (ACLF) is a serious clinical entity, with no previous reports in Chile. Aim: To characterize patients with ACLF in a Chilean University Hospital, identifying triggers, organ failure and survival at 30, 90, 180 days, compared to patients with decompensated cirrhosis without ACLF. Methods: Retrospective cohort study of decompensated cirrhotic patients hospitalized in a chilean University Hospital between 2017-2019. Results: 334 patients were included, 73 (22%) presented ACLF (33% ACLF-1, 30% ACLF-2, 37% ACLF-3); 16.4% underwent liver transplantation. Patients with ACLF were younger, and had higher MELD-Na and APACHE II on admission. The most common triggers in both groups were infections (42.4%), gastrointestinal bleeding (23.2%) and alcohol intake (31.3%). The main organ failures were kidney (60.2%) and brain (49.3%). All organ failures were more frequent in ACLF-3, except renal failure (greater in ACLF-1). Survival at 180 days was 74% in patients without ACLF and 58.3% in ACLF (p=0.004). Mortality was significantly higher in ACLF-2 and ACLF-3, when compared with patients without ACLF (HR 2.3 and 2.99, respectively; p

La presente investigación tiene como objetivo fortalecer la competencia comunicativa a través de una Guía Virtual Interactiva con Recursos Educativos Digitales en los estudiantes de grado 9 de la Institución Educativa Marceliano Polo del municipio de Cereté – Córdoba. El método que orientará esta propuesta es la investigación cualitativa la cual incorpora herramientas que permiten interpretar el actuar de la población a investigar. Esta investigación aplica el modelo de Investigación Basado en Diseño (IBD) debido a que permite transformar una situación problema por medio del diseño de una herramienta tecnológica aportando significativamente a los ambientes de aprendizajes siendo esto un referente para guiar asertivamente el proceso de fortalecimiento de la competencia comunicativa en lengua castellana mediante la guía virtual interactiva. En el proceso metodológico se definieron tres categorías de estudio como son: Competencias comunicativas, Guía virtual interactiva y Recursos educativos digitales, se acudió a los instrumentos de recolección de la información como lo son: la guía de análisis, guía virtual interactiva, guía y análisis de encuesta, con los cuales se pudo aplicar el diagnóstico, la guía virtual interactiva y obtener la información sobre los posibles resultados e impacto de la estrategia de intervención. Los resultados evidencian que la guía virtual interactiva con recursos educativos digitales es una estrategia pedagógica que permite mejorar en los estudiantes la competencia comunicativa en lectura y escritura siendo esto de gran contribución para aumentar el desempeño de los educandos en las pruebas externas ICFES Maestría Magister en Recursos Digitales Aplicados a la Educación

Este proyecto recopila los elementos que han servido como base para la creación de una primera versión de un guion cinematográfico en el que se narra una historia de ficción para una película musical. Este documento contiene un importante elemento de exploración que contextualiza al musical como género cinematográfico, con referencias a la historia y evolución de este. En este, también se incluyen datos importantes sobre los temas que son abordados en el guion, especialmente los relacionados con algunas expresiones sociales y culturales de la región pacífica colombiana. Estos elementos han aportado a la construcción del relato y han sido indispensables para darle una perspectiva objetiva a la obra. El documento, también incluye los pasos que se han llevado a cabo para el desarrollo del guion, así como todo lo requerido para demostrar su validez ante los entes académicos de la Universidad Autónoma de Occidente, cumpliendo con los parámetros establecidos por la institución para la presentación de trabajos de grado de la Facultad de Humanidades y Artes. Proyecto de grado (Profesional en Cine y Comunicación Digital)-- Universidad Autónoma de Occidente, 2021 Pregrado Profesional en Cine y Comunicación Digital

Cats (Felis silvestris catus) are one of the most pernicious invasive species on islands, being responsible for the decline and extinction of many vertebrate taxa. Eradications programs are a powerful tool to fight against cat impacts on islands, but their implementation requires planning and design to prevent failure. In that sense, gathering data on cat habitat use, abundance and trophic interactions provides key information to effectively design management actions. The present contribution presents a simple resource-efficient methodology using cat feces to assess cat distribution, density and trophic ecology on an inhabited islet. This information is essential in order to effectively organize trapping efforts and minimize subsequent impacts of other species if a control or eradication campaign is undertaken. Additionally, our research effort evaluated the potential influence of coastal and anthropic resources on cat diet, which can also provide useful information for planning aside management actions. Cat distribution on our model islet, La Graciosa, was ‘clumped’, presenting higher densities in anthropic areas (villages and farms). The invasive house mouse and the European rabbit were the main prey items, although native invertebrates, reptiles and birds were also consumed. Cats on La Graciosa ingested a large quantity of garbage, which was negatively correlated with distance from human settlements. Considering the low time and resource requirements of this methodology, and the useful basic ecological information it provides, it can be employed to make optimal management planning decisions for small inhabited islands where cat control or eradication programs are being considered., This study was funded by the Cabildo of Lanzarote (1701.48000). MLD was funded by a program of Cabildo Insular de Tenerife, under the identification mark “Tenerife 2030” (P. INNOVA 2016-2021). JCP was funded by a Canary Islands Government PhD fellowship (TESIS 2017010051).

Actualmente, un buen manejo de la información para regular el control interno es esencial para para cualquier empresa. Un punto de extrema importancia es el control de inventario, que se realiza con el objetivo de desplegar predicciones de ventas o presupuesto, para definir costos de inventarios, compras, recepción, almacenaje, producción, embarque y contabilidad. Sin embargo, muchas PYMES siguen implementando el control de su inventario de manera tradicional, es decir, realizando todos los registros mediante el uso de papel y bolígrafo. El método tradicional entorpece el proceso de gestión debido a la alta probabilidad de cometer errores, alto consumo de tiempo y baja o nula trazabilidad de la información. Por esta razón, el presente proyecto tiene como propósito desarrollar un sistema integral de gestión de inventario basado en la Nube que se ajuste a las necesidades de una empresa. Después de estudiar los requerimientos de la empresa haciendo uso de BPMN y evaluar diferentes tecnologías, el sistema finalmente está constituido por: una aplicación web alojada en una instancia EC2 de Amazon Web Services. También, se utiliza una base de datos relacional proporcionada por el servicio RDS de AWS. Adicionalmente, para desarrollar la aplicación se hace uso de dos tecnologías para el desarrollo frontend y backend muy populares y robustas como lo son ReactJS y Nodejs. A la aplicación web se integra una aplicación móvil que permite la lectura de códigos de barra y un lector RFID implementado con una Raspberry Pi 4, ambas conectadas directamente a la base de datos. Además, se realiza el análisis financiero de esta última para evaluar su viabilidad en la empresa escogida. En conclusión, se implementó un sistema integrado para la gestión de inventarios basado en la Nube en una empresa pequeña de manufactura del sector textil y se consiguieron buenos resultados en la evaluación de su usabilidad. Currently, good information management to regulate internal control is essential for any company. An extremely important point is inventory control, which is carried out with the objective of displaying sales or budget predictions, to define costs of inventories, purchases, reception, storage, production, shipping and accounting. However, many SMEs continue to implement their inventory control in a traditional way, that is, making all the records using paper and pen. The traditional method hinders the management process due to the high probability of making mistakes, high time consumption and low or no traceability of the information. For this reason, the present project aims to develop a comprehensive cloud-based inventory management system that meets the needs of a company. After studying the requirements of the company using BPMN and evaluating different technologies, the system finally consists of: a web application hosted on an EC2 instance of Amazon Web Services. Also, a relational database provided by the AWS RDS service is used. Additionally, to develop the application, two very popular and robust technologies are used for frontend and backend development, such as ReactJS and Nodejs. A mobile application is integrated into the web application that allows the reading of bar codes and an RFID reader implemented with a Raspberry Pi 4, both connected directly to the database. In addition, the financial analysis of the latter is carried out to evaluate its viability in the chosen company. In conclusion, an integrated cloud-based inventory management system was implemented in a small textile manufacturing company and good results were achieved in evaluating its usability.

Los switch transaccionales son plataformas tecnológicas que son usadas por entidades bancarias o financieras a nivel mundial, que tienen una red distribuida de medios de pagos físicos (Datafonos) o electrónicos (eCommerce). Estos cuentan con diferentes tecnologías que evolucionan con el pasar del tiempo, en especial las telecomunicaciones fijas o inalámbricas, ya que son la carretera informática rápida y segura donde fluyen los requerimientos, autorizaciones o anulaciones de las transacciones financiera de los comercios y los consumidores que usan sus tarjetas de crédito / débito o billeteras electrónicas. En el presente trabajo se realiza la propuesta de implementación de un switch transaccional financiero para administrar los medios de pagos de las entidades bancarias conectadas a NetPay S.A. En el primer capítulo se realiza un análisis de los principales fundamentos teóricos y funcionales de los switch transaccionales de manera general, tales como: Puntos de Ventas (POS), Cajeros Automáticos (ATM), Adquirencia/Afiliación de comercios, Billeteras Electrónicas (eWallet), Corresponsales no Bancarios (CNB), Comercio Electrónico (eCommerce). La variedad de medios de telecomunicaciones aplicados en los diferentes escenarios de cada servicio del switch transaccional anteriormente mencionados son presentados en el segundo capítulo donde se los utilizada de forma segura y eficaz. En el tercer capítulo se realiza el diseño y la propuesta integral de como NetPay S.A., puede interconectar los servicios financieros de las entidades bancarias interconectadas a ellos, luego en el cuarto capítulo se muestra como mediante una sola plataforma escalable y funcional, se optimiza las operaciones y siendo más eficiente el uso de los recursos disponibles para los clientes y sus transacciones financieras, indiferentes de los medios de pagos que pueda usar. Transactional switches are technological platforms that are used by banking or financial entities worldwide, which have a distributed network of physical (Dataphones) or electronic (eCommerce) means of payment. These have different technologies that evolve over time, especially fixed or wireless telecommunications, since they are the fast and secure computer highway where the requirements, authorizations or cancellations of the financial transactions of the businesses and consumers who use flow. your credit / debit cards or electronic wallets. In this work, the proposal for the implementation of a financial transactional switch is made to manage the means of payment of banks connected to NetPay S.A. In the first chapter, an analysis of the main theoretical and functional fundamentals of transactional switches is carried out in general, such as: Sales Points (POS), ATM, Purchase/Business Affiliation, Electronic Wallets (eWallet), Non-Bank Correspondents (CNB), Electronic Commerce (eCommerce). The variety of telecommunications means applied in the different scenarios of each transactional switch service mentioned above are presented in the second chapter, where they are used safely and efficiently. In the third chapter the design and comprehensive proposal of how NetPay SA can interconnect the financial services of the banking entities interconnected to them is carried out, then in the fourth chapter it is shown how through a single scalable and functional platform, operations are optimized and the use of the resources available to clients and their financial transactions being more efficient, regardless of the means of payment they may use.

The CLIL methodology has acquired a great impact upon non-university education. Its proliferation in the Canary Islands (Spain) has been considerable during this century by means of transitional programs that aims to introduce the simultaneous learning of language and contents. This study aimed to analyze how the different areas such as sources, strategies, parental and academic support, the motivation, etc. take part in the bilingual program and how they contribute to the learning process of students. Firstly, a theoretical approach will be developed taking into account issues such as the importance of getting to know the consequences caused by moving from one educational stage to a different one and the gradual introduction and development of the CLIL methodology in the Canary Islands. Afterwards, 50 students belonging to the first year of Secondary Education and inserted in the CLIL methodology have been selected. A questionnaire has been utilized as an evaluative instrument that goaled to detect those areas that require to be revised and improved in the bilingual program. The different areas created for result analysis are the following: use of materials and resources regarding CLIL methodology, utilization of the foreign language and mother language, use of other different methodologies within CLIL, evaluation, degree of motivation and reflection upon the experience. These results have demonstrated the need to combine the different elements that are applied in the academic activity in a bilingual environment. It has been also resulted the necessity to revise the selection of human resources and to generate more professional training regarding the utilization of CLIL methodology. Above all, the results have revealed the great relevance and necessity to make a gradual study of pupils who are starting Secondary Education because of the dual handicap they may suffer: change in the educative context and the learning through a foreign language.

This study examined the effects of a large-scale flipped learning (FL) approach in an undergraduate course of Digestive System Diseases.This prospective non-randomized trial recruited 404 students over three academic years. In 2016, the course was taught entirely in a Traditional Lecture (TL) style, in 2017 half of the course (Medical topics) was replaced by FL while the remaining half (Surgical topics) was taught by TL and in 2018, the whole course was taught entirely by FL. Academic performance, class attendance and student's satisfaction surveys were compared between cohorts.Test scores were higher in the FL module (Medical) than in the TL module (Surgical) in the 2017 cohort but were not different when both components were taught entirely by TL (2016) or by FL (2018). Also, FL increased the probability of reaching superior grades (scores7.0) and improved class attendance and students' satisfaction.The holistic FL model is more effective for teaching undergraduate clinical gastroenterology compared to traditional teaching methods and has a positive impact on classroom attendances.

El grado de desarrollo alcanzado por la Genética español; durante el primer tercio del siglo XX se debió fundamentalmente a la actividad de la Junta para la Ampliación de Estudios e Investigaciones Científicas, que pensionaba jóvenes investigadores españoles en los mejores laboratorios de investigación genética de la época; tal es el caso de José Fernández Nonídez (1892-1947), que en la Universidad de Columbia trabajó junto a Thomas H. Morgan (1866-1945) y Edmund B. Wilson (1856-1939). De la Junta dependieron, además, las dos instituciones más importantes en el desarrollo de la Genética en España de estos años: el Laboratorio de Biología y la Misión Biológica de Galicia.

The objective of this work was to demonstrate how the extraction method affects the reliability of biomarker detection and how this detection depends on the biomarker location within the cell compartment. Different extraction methods were used to study the sarcoplasmic and myofibrillar fractions of the Longissimus thoracis et lumborum muscle of young bulls of the Asturiana de los Valles breed in two quality grades, standard (Control) or dark, firm, and dry (DFD) meat. Protein extractability and the expression of some of the main meat quality biomarkers—oxidative status (lipoperoxidation (LPO) and catalase activity (CAT)), proteome (SDS-PAGE electrophoretic pattern), and cell stress protein (Hsp70)—were analyzed. In the sarcoplasmic fraction, buffers containing Triton X-100 showed significantly higher protein extractability, LPO, and higher intensity of high-molecular-weight protein bands, whereas the TES buffer was more sensitive to distinguishing differences in the protein pattern between the Control and DFD meat. In the myofibrillar fraction, samples extracted with the lysis buffer showed significantly higher protein extractability, whereas samples extracted with the non-denaturing buffer showed higher results for LPO, CAT, and Hsp70, and higher-intensity bands in the electrophoretic pattern. These findings highlight the need for the careful selection of the extraction method used to analyze the different biomarkers considering their cellular location to adapt the extractive process.

En el presente trabajo de investigación, debido a la baja productividad, competitividad y la insostenibilidad actual de la cadena productiva de la vid en la provincia Gran Chimú, se planteó como objetivo general presentar un modelo de cadena productiva de vid para incrementar su productividad, competitividad y hacerla sostenible. La investigación es básica, con diseño no experimental transversal descriptivo, se utilizó como instrumento un cuestionario validado por expertos, que constó de 25 ítems, la población lo constituyen 1200 productores de vid en la provincia Gran Chimú y se trabajó con una muestra de 292 agricultores a los cuales se aplicó el cuestionario, la confiabilidad obtenida fue de 0.89, los resultados encontrados indican, una baja productividad en toda la cadena, actores no competitivos a lo largo de la cadena y lo más preocupante que a pesar de tener las condiciones ambientales no se logra la sostenibilidad de la cadena, una escasa participación del estado, políticas sectoriales inadecuadas, limitada tecnología, desmotivación de los productores, desvinculación e inequidad en los eslabones de la cadena que en un contexto globalizado limitan la competitividad en los principales mercados agroalimentarios. Chiclayo Escuela de Posgrado Reforma y Modernización del Estado

Los celos son un fenómeno complejo de gran interés que han sido objeto de estudio de la psicología, existiendo diversas definiciones. Sin embargo, todas ellas tienen en común que se trata de una reacción emocional intensa y negativa que se produce debido a la sospecha real o imaginada de que la pareja afectiva está teniendo algún tipo de relación sexual o emocional con otra persona. El objetivo de esta revisión es entender cómo influyen los celos en las relaciones de pareja, de qué forma lo hacen y cómo se relacionan con otras variables como la infidelidad, la satisfacción marital y la violencia. También se busca saber si existen diferencias entre hombres y mujeres ante las situaciones desencadenantes de celos y ante la reacción emocional que tienen frente a dicho episodio. Para ello se realizó una búsqueda sistemática en el portal Punto Q. De los 66 resultados encontrados se seleccionaron 13 estudios. Se ha evidenciado que los celos afectan negativamente a la relación, produciéndose en muchos casos episodios de violencia y control del otro miembro de la pareja. Sin embargo, los resultados obtenidos son contradictorios tanto en el tipo de situación desencadenante de celos como en la expresión emocional que hombres y mujeres tienen ante dicho episodio. Jealousy is a complex phenomenon of interest that has been subject of study in psychology, with various definitions. However, all of them have in common that it is an intense and negative emotional reaction that occurs due to the real or imagined suspicion that the affective partner is having some kind of sexual or emotional relationship with another person. The objective of this review is to understand how jealousy influences couple relationships, how it does so and how it is related to other variables such as infidelity, marital satisfaction and violence. It also seeks to know if there are differences between men and women in the situations that trigger jealousy and in their emotional reaction to such an episode. A systematic search was done at Punto Q. Of the 66 results found, 13 studies were selected. Jealousy has been shown to negatively affect the relationship, producing in many cases episodes of violence and control of the other member of the couple. However, the results obtained are contradictory both in the type of situation that triggers jealousy and in the emotional expression that men and women have when faced with said episode.

El objetivo principal fue desarrollar un Modelo de unidad de gestión educativa local en la calidad de gestión educativa, usándose un enfoque mixto para la recolección de datos, se consideró la estadística como un proceso probatorio y la generalización de resultados. Su metodología es de tipo de investigación propositiva cuyo diseño es simple, propositivo. La población fue de 24 directivos y docentes y en el uso de instrumentos se aplicó la técnica de la encuesta y como instrumentos dos escalas de opinión de 28 enunciados para el Modelo de Gestión y con 32 enunciados para el instrumento de calidad de gestión educativa. La validez de los instrumentos generados fue dada por juicio de expertos y se usó el coeficiente Alfa de Cronbach (0.895) para hallar la confiabilidad. Se validó el modelo de gestión considerando a los directivos y docentes, los trabajadores y usuarios a fin de mejorar la calidad de gestión, además, se hizo un diagnóstico de la calidad de gestión encontrándose deficiencias en la equidad, relevancia, persistencia y eficiencia en la calidad de gestión educativa. Se propuso un modelo de gestión para la calidad de gestión educativa, donde se tiene en cuenta el eje personal, transformacional, relacional y trascedental. Trujillo Escuela de Posgrado Gestión y Calidad Educativa Biodiversidad, cambio climático y calidad ambiental Promoción de la salud, nutrición y salud alimentaria Fin de la pobreza

El objetivo del presente estudio, consiste en analizar el derecho a la protección de datos y entender la razón de ser jurídica de la presente institución. También, se centra en el desarrollo de la misma tanto a nivel europeo como estatal hasta alcanzar la regulación actual. Finalmente, tomando como figura principal la protección de datos de los menores, analizaremos los peligros a los que están expuestos cuando llevan a cabo el uso de los servicios de la información, y en concreto, de las Redes Sociales. The main goal of the present study is to analyze the right to data protection and also to understand the legal reason to be of the present institution. Furthermore, the study is focused on the evolution of data protection itself on the European level and on the state level until the actual regulation. Finally, and having underage data protection as the main figure, we are going to analyze underages that are exposed when they use information services, specifically when they use social networks.

espanolEn el ganado vacuno, el estres pre-sacrificio provoca la aparicion de carnes conocidas como DFD (Dark,Firm, Dry), que se identifican por un descenso anomalo del pH muscular post-mortemy que muestranserios problemas de calidad, lo cual disminuye su valor comercial. El objetivo de este trabajo es conocerlas diferencias en los procesos de estres oxidativo, en los mecanismos de supervivencia/muerte celular(autofagia/apoptosis) y en biomarcadores proteomicos a las 24 h post-mortem,entre canales que mos-traron un descenso normal de pH (pH = 5,4-5,8 a las 24 h post-mortem) utilizadas como CONTROL y ca-nales con pH a las 24 h post-mortem(pH24) > 6,0 clasificadas como DFD, con el fin de identificar los pro-cesos del metabolismo muscular ligados a la aparicion de carnes DFD.Se analizo el estres oxidativo celular mediante el estudio de la actividad antioxidante total y los danosen macromoleculas (proteinas y lipidos). Las carnes DFD mostraron mayor actividad antioxidante (P EnglishIn cattle, pre-slaughter stress causes the appearance of DFD (Dark, Firm, Dry) beef, with defective post-mortemmuscle pH decline and detrimental quality that reduce its commercial value. This paper aimsto study differences in oxidative stress, cell survival or death mechanisms (autophagy/apoptosis) and proteomic biomarkers at 24 h post-mortembetween beef carcasses with normal pH decline (pH = 5.4-5.8at 24 h post-mortem) used as CONTROL and carcasses with pH at 24 h hours post-mortem(pH24)> 6.0classified as DFD, in order to understand the relevant changes on the early post-mortemmuscle me-tabolism related to the DFD occurrence.Cell oxidative stress was analyzed as total antioxidant activity and damage of macromolecules (proteinsand lipids). The results showed that DFD meat had increased muscle antioxidant activity (P

Marine invertebrates are a significant source of biologically active compounds. Recent studies have highlighted the role of microbiota associated with marine invertebrates in the production of bioactive compounds. Corals and sponges are the main marine invertebrates producing bioactive substances, and Symbiodiniaceae dinoflagellates are well-recognized endosymbionts with corals and sponges playing vital functions. The biological properties of Symbiodiniaceae-derived compounds have garnered attention in the past decades owing to their ecological implications and potentiality for bioprospecting initiatives. This study aims to systematically review studies on bioactivities and potential biotechnological applications of Symbiodiniaceae-derived compounds. The PRISMA guidelines were followed. Our study showed that anti-inflammatory and vasoconstrictive activities of Symbiodiniaceae-derived compounds have been the most investigated. However, very few studies have been published, with in vitro culturing of Symbiodiniaceae being the most significant challenge. Therefore, we surveyed for the metabolites reported so far, analyzed their chemodiversity, and discussed approaches to overcome culturing-related limitations.

En los últimos años la presión de los clientes y de cier- tas comunidades organizadas que debaten el comporta- miento ético de las empresas, o que promueven el veto a productos elaborados por empresas controvertidas por sus actuaciones en los campos social, económico o ambiental, así como el hecho de que los inversionistas y las compañías aseguradoras consideran un factor de riesgo el que una empresa termine cuestionada por es- tos aspectos, han creado motivos adicionales para que una empresa actúe responsablemente. Por otra parte tanto a nivel mundial como en Colombia, muchas Pymes han implementado y certificado un sistema de gestión de la calidad como respuesta a necesidades internas o a circunstancias del mercado; ese conoci- miento organizacional y esas experiencias en el mane- jo de un sistema de gestión de la calidad se podrían aprovechar para facilitar la inserción de las prácticas de la responsabilidad social en las Pymes, mejorando su posición competitiva. Esta investigación exploró la po- sibilidad de integrar el sistema de gestión de la calidad de Pymes certificadas bajo el modelo ISO 9001 con los principios y prácticas de responsabilidad social tal como se plantean en las normas Guía sobre responsa- bilidad social ISO 26000 (WD 4.2) y Responsabilidad social laboral SA 8000:2001. Se utilizó una metodología de observación participante, seleccionando tres Pymes para efectuar una prueba piloto que, a través de una consultoría en la implementación de las normas ante- riormente mencionadas, hiciera evidentes las ventajas o dificultades de integrar la responsabilidad social a un sistema de gestión de la calidad en funcionamiento.

Resumen del trabajo presentado al European Congress on Advanced Materials and Processes (EUROMAT), celebrado virtualmente del 13 al 17 de septiembre de 2021.