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Abstract: Organic dye-based nanoparticles (ODNPs) are fabricated with desired morphologies using laser ablation, reprecipitation, ion association, and self-assembly methods. Primitively, this review introduces the theory of the molecular origins of dye aggregation, manifestations of the formations of monomer to J-dimer, H-dimer, and oblique dimer (mixed J and H dimer) in ODNPs. Although, organic dye nanoparticles have better basic properties than their monomer counterparts. These nanoparticles are suitable candidates for many engineering and technical applications. Furthermore, we have discussed OLEDs, optoelectronics, sensing, environmental, light-harvesting antennas, cryptography, and biomedical imaging applications. The conclusion made from the critical review analysis opens up a new horizon for the future development of ODNPs applications.

The aim of this study was: (1) to develop an appropriate circuit training program for biomotor improvement that supports Teng Kong Bai Lian (TKBL), (2) to examine the feasibility of biomotor improvement that supports TKBL, and (3) to examine training program effectivity. This study is a kind of Research and Development through several procedures, such as observation and data collection, planning, program development, expert validation, initial program revision, small scale trial, large scale trial, operational program revision, effectivity test, and completion program, and training program implementation. Instrument of this study consist of observation, questionnaire for expert validation, test and measurement biomotor including (1) t-test for measuring speed and agility, (2) leg dynamometer for leg strength, (3) vertical jump for leg power, (4) curl-up test for core strength, (5) modified bass test of dynamic balance for measuring dynamic balance. The results of the collected data will be analyzed using Aiken for expert validation, and small and large-scale trials, while the paired sample t-test with SPSS is used to analyze the effectiveness test. Expert validation, small-scale trial, and large-scale trial were analyzed using the Aiken method with Aiken table value, whereas the effectivity test was analyzed using paired sample t-test on the SPSS application. The result showed that expert validation for the training program was obtained above 0.80 Aiken value for all test items. The results of the effectiveness test showed a significant effect on increasing the biomotor component of leg muscle strength, core strength, leg muscle explosive power, speed and agility with a P value of 0.000, but the effect was not significant on the balance component where the P value was 0.840. Based on the results of the study, it can be concluded that the ciccuit training program can effectively increase leg muscle strength, core strength, leg muscle explosive power, speed and agility, but does not improve balance. So this training program can be applied to Wushu Taolu athletes to improve their biomotor abilities to support the TKBL movement.Keywords: Wushu, circuit training program, strength, core strength, power, speed, agility, balance

Surrogate markers of metabolic syndrome complications is high levels of glucose and/or cholesterol in the blood. The purpose of this research is to determine whether or not various intensity exercise has a beneficial impact on blood glucose and cholesterol levels in young adults. As a consequence, this study was investigated about how exercise's influence on lowering the risk of metabolic diseases may be moderated by other factors, including by milk intake. Studies were conducted using a quasi-experimental, single-blind research design. Thirty-five participants were randomly assigned to one of four groups: control (C), moderate intensity (M), high intensity (H), or intermittent (I). The Sysmex XN-1000 is used for checking blood content, while the Cobas Pro is used to analyze blood chemistry in the lab. Using tools like the analysis of variance (ANOVA), the Mann-Whitney test, and the Pearson correlation coefficient, researchers may gauge the importance of inherent correlations and examine how group-level phenomena and interactions affect those coefficients. To sum up, we found that there was a statistically significant difference in glucose levels between the control group and the experimental group (p = 0.012 < 0.05), yet this difference was accompanied by a negative trend showing a rise in content. Also, there was a favorable tendency toward lower glucose and cholesterol levels across all compositions, while it was not statistically significant (p value > 0.05). To sum up, practically all of the variables point to a favorable tendency that that does not statistically significant – in the effect of exercise intensity combined with milk consumption. Exercise and milk intervention have been shown to have positive impacts, but further investigation or longer training sessions are needed to determine their true magnitude.

Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kidney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a randomized controlled trial.Setting & Participants: Participants in the CREDENCE trial.Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kidney failure, doubling of serum creatinine concentration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Outcomes were evaluated by age at baseline (Results: The mean age of the cohort was 63.0 ± 9.2 years, and 34% were female. Older age and female sex were independently associated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (a composite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.48-0.82], and 0.89 [0.61-1.29] for ages Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791.

This study uses numerical modeling in combination with rock mass classification approaches to develop tunnel support systems that are safe from earthquakes, ultimately contributing to the seismic resilience of the important infrastructure. A case study of tunnel in Himalayan region of Nepal has been considered for seismic assessment of tunnel supports in different geological conditions. For better quality rock masses (GSI>30), strain-softening model was used, and for weaker rock masses (GSI

Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive endoscopic technique that has many diagnostic and therapeutic implications. It is a procedure with small but significant life-threatening complications. To ensure the best possible care, minimize complications, and improve the quality of health care, a constant review of the performance of the operator using ideal benchmark standards is needed. Hence, quality indicators are necessary. The American and European Societies of Gastrointestinal Endoscopy have provided guidelines on quality measures for ERCP, which describe the skills to be developed and training to be implemented in performing quality ERCP. These guidelines have divided the indicators into pre-procedure, intraprocedural, and post-procedure measures. The focus of this article was to review the quality indicators of ERCP.

Sometimes, it is very difficult for someone to determine whether a person wants to hear a particular music from the vast array of available choices. So, this paper has proposed a new concept of playing music that is based on the emotion of the user. The primary goal of the music recommendation system which is proposed in this paper is to offer customers recommendations that match their tastes. The most current view of the paper involves manually playing the jukebox, using wearable computers, or classifying based on auditory characteristics. Understanding the user's present emotional or mental state may result from analysing the user's facialexpression and emotions. One area is having a great possibility to provide the audience, with a vast variety of options that are based on their preferences and music and video. In this paper, the primary goal is to show a playlist of songs on any particular music application (YouTube/Spotify) based on each person’s mood. Several images of the user are collected at that precise moment using a camera with the user's consent. To determine a person's mood, these photos go through a thorough testing andtraining process. For this, the deep learning technique called CNN is used to categorize various emotions. After this, based on the trained model, the various emotions are categorized and based on this the music playlist is generated.

This paper attempts to provide a first step toward understanding the role of credit portfolio management in Nepalese microfinance institutions (MFIs) and overcome those problems associated with credit risk management. The credit portfolio management (CPM) has become most crucial functions of the Nepalese MFIs for sound loan portfolio quality. This study is based on descriptive research design. Several findings are made through the review of the literature that is parallel to achieving the objectives of the study. MFIs are financial intermediaries ("banks") that have a direct impact on economic and social transformation, such as job creation, income generation, social change, and poverty alleviation via financial and non-financial activities. The findings show that a credit appraisal system, scientific interest rate, credit monitoring, loan portfolio diversification system, capital optimization, risk framework development, regulatory management, credit control, credit advisory, and credit research, have reduced credit risk and ensured high-performing loans and financial sustainability. The study recommends that MFI’s portfolio management strategies focus more on the internal causes of delinquency which they have more control over and seek practical and achievable solutions to reimbursement delinquency problems. The study's findings will be useful to BFIs, institutional lenders, microfinance experts, regulators, economists, policymakers, and institutional credit rating agencies. The result reveals that portfolio diversification has a significant impact on credit portfolio management in Nepalese MFIs.

Cloud computing has emerged as a significant technology domain, primarily due to the emergence of big data, machine learning, and quantum computing applications. While earlier, cloud computing services were focused mainly on providing storage and some infrastructures/platforms for applications, the need to advance computational power analysis of massive datasets. It has made cloud computing almost inevitable from most client-based applications, mobile applications, or web applications. The allied challenge to protect data shared from and to cloud-based platforms has cropped up with the necessity to access public clouds. While conventional cryptographic algorithms have been used for securing and authenticating cloud data, advancements in cryptanalysis and access to faster computation have led to possible threats to the traditional security of cloud mechanisms. This has led to extensive research in homomorphic encryption pertaining to cloud security. In this paper, a security mechanism is designed targeted towards dynamic groups using public clouds. Cloud security mechanisms generally face a significant challenge in terms of overhead, throughput, and execution time to encrypt data from dynamic groups with frequent member addition and removal. A two-stage homomorphic encryption process is proposed for data security in this paper. The performance of the proposed system is evaluated in terms of the salient cryptographic metrics, which are the avalanche effect, throughput, and execution time. A comparative analysis with conventional cryptographic algorithms shows that the proposed system outperforms them regarding the cryptographic performance metrics.

The issue of the COVID-19 and its impact on higher education is an emergent focus of debate across the globe. Higher education sectors all over the world are exceptionally disordered and disrupted radically and students are struggling a lot to navigate this crisis. An Analysis of Higher Education, Placement, Employment and Earning Contours of TNAU Farm graduates during the Pre and Post COVID 19 Regimes was conducted with the following objectives. For the present study, 372 past candidates were contacted. Data was collected by mailed Questionnaire. The issue of the COVID-19 and its impact on higher education is an emergent focus of debate across the globe. Higher education sectors all over the world are exceptionally disordered and disrupted radically and students are struggling a lot to navigate this crisis. Among the respondents 57 per cent were girls and 43 percent were boys. Around 42 per cent of the graduates were from rural background, 31% from urban and remaining from peri-urban areas. Over 61 per cent of the passed out graduates were preparing for competitive examinations, 26 per cent were pursuing higher education and only 13 per cent were employed. The percentage of graduates doing higher education and employed has reduced by nearly 50 percent during the COVID. All the students were employed within India during the pre and post COVID period and the difference between these periods was negligible. However it could be noted that the number of graduates being employed in private sector reduced drastically in the first year of Covid while it increased by 35 percent during the second year after CoVID. The choice of jobs were prioritized in the following preference. They were Salary, passion and job security. However it can be found that the job security aspect has reduced by 20 percent in the Covid situation. About 59 per cent indicated that their jobs were not secured and 36 per cent expressed that they found it difficult to get admission in national and international institutions due to covid pandemic and 17.2 per cent indicated that they were not able to pursue education in National and International institutions even after getting admissions and fellowships. COVID has impacted higher education and job prospect in abroad and far way places.

Ever increasing global population necessitates the need to increase availability of affordable foods with high nutritional quality. Chickpea being the second most important grain legume cultivated worldwide has the great potential to alleviate problems of protein malnutrition and hidden hunger. The objective of the present investigation was to characterize a diverse set of 402 germplasm comprising of more than 100 commercial cultivars widely cultivated and utilized by breeders for grain protein in two contrasting environments to explore the magnitude of natural genotypic diversity present in the cultivated chickpea and the scope for enhancing it and its quality through breeding. The cultivars containing more than 25 to 30.44% grain protein have been found in the study and large scale production of such protein rich cultivars is expected to increase availability as well as consumption of high quality chickpea necessary to overcome all forms of malnutrition. Trait specific germplasm containing grain protein up to 33.56% are also identified for their further utilization as potential donors in the chickpea improvement programme. The amino acid profiling of selected high and low protein containing genotypes showed considerably greater average amino acid score for all the essential amino acids than the WHO recommended requirement values and is comparable to those of the ‘complete protein’ sources of food suggesting that chickpea deserves to be considered as a ‘complete protein’ source.

Following a tissue injury/ damage, the regeneration of cells at the affected area is very critical. Fewer cell types like dermal cells are capable of cellular division to a smaller extent. But following more significant cellular damage, there comes an urgent need to replace these defective cells or tissues, where most traditional approaches of medicinal treatments fail. Tissue engineering offers an alternative solution that is more ideal under these circumstances. It is an interdisciplinary field of science that tries to integrate life science into engineering principles with the purpose of replacing damaged cells/tissues. In addition, the overall process of tissue growth and differentiation in vivo requires the presence of various growth factors at the nano-sized range. The current trend is to encompass nanotechnology along with tissue engineering aspects. Scaffolds being the most important component of tissue engineering application, the electrospinning process is used to generate nanofibrous scaffolds. Electrospinning makes use of different natural and synthetic polymers. These polymers can provide structural support upon which cellular growth occurs and hence these polymers are suitable for various biomedical applications. This review study attempts to cover the basics of the electrospinning process, different natural and synthetic polymers and their significant biomedical applications.

Background: Pregnancies that occur below the age of 20 years are called teenage pregnancies. Teenage pregnancy is a common public health problem worldwide which is detrimental to the health of both the mother and the new-born. This study aims to evaluate the obstetric and perinatal outcomes of teenage pregnancy in the Indian rural and semi urban population. Methods: A retrospective observational study was undertaken in the department of obstetrics and gynecology, Mysore Medical College and Research Institute, Mysore, for a period of one year from August 2021 to September 2022. All the teenage mothers during the study period were included in the study. Data was analysed included various maternal parameters, fetal parameters, and the outcome of pregnancy. Results: Study showed the incidence of teenage pregnancy is 12.6%. About 88.3% were primgravida, 74% were booked cases. 51.6% of the teenage mothers had varying grades of anaemia, 29.09% of teenage mothers had spectra of hypertensive disorders if pregnancy, 27.92% had PROM. Caesarean section rates were 25%, Fetal distress being the most common indication in 47.3% followed by fail induction in 29.8%. Preterm delivery rates were as high as 13.6%. Postpartum complications included postpartum hemorrhage in 2.5%, puerperal pyexia in 1.9%, postpartum eclampsia in 1.38%. Respiratory distress was seen in 17.6% neonates, prematurity in 15.49%, IUGR in 13.6%, 2.99% were stillborn send 3.36% succumbed due to pre-maturity, respiratory distress, and sepsis. Conclusions: From the present study we infer that the prevalence of teenage pregnancy is still high in rural and semi urban population and they suffered from a significant number of complications in pregnancy including anemia pre-eclampsia and preterm labour, neonatal respiratory distress and early onset sepsis. To surmount these problems a multidisciplinary team involving health and social workers, obstetrician and gynaecologist are required to improve adolescent reproductive health.

We introduce an approach for converting pixel art into high-quality vector images. While much progress has been made on automatic conversion, there is an inherent ambiguity in pixel art, which can lead to a mismatch with the artist's original intent. Further, there is room for incorporating aesthetic preferences during the conversion. In consequence, this work introduces an interactive framework to enable users to guide the conversion process towards high-quality vector illustrations. A key idea of the method is to cast the conversion process into a spring-system optimization that can be influenced by the user. Hereby, it is possible to resolve various ambiguities that cannot be handled by an automatic algorithm.

This paper examines factors associated with intimate partner violence (IPV) among newly married women in Nepal, and how IPV was affected by food insecurity and COVID-19. Given evidence that food insecurity is associated with IPV and COVID-19, we explored whether increased food insecurity during COVID-19 is associated with changes in IPV. We used data from a cohort study of 200 newly married women aged 18-25 years, interviewed five times over two years at 6-month intervals (02/2018-07/2020), including after COVID-19-associated lockdowns. Bivariate analysis and mixed-effects logistic regression models were used to examine the association between selected risk factors and recent IPV. IPV increased from 24.5% at baseline to 49.2% before COVID-19 and to 80.4% after COVID-19. After adjusting for covariates, we find that both COVID-19 (OR = 2.93, 95% CI 1.07-8.02) and food insecurity (OR = 7.12, 95% CI 4.04-12.56) are associated with increased odds of IPV, and IPV increased more for food-insecure women post COVID-19 (compared to non-food insecure), but this was not statistically significant (confidence interval 0.76-8.69, p-value = 0.131). Young, newly married women experience high rates of IPV that increase with time in marriage, and COVID-19 has exacerbated this, especially for food-insecure women in the present sample. Along with enforcement of laws against IPV, our results suggest that special attention needs to be paid to women during a crisis time like the current COVID-19 pandemic, especially those who experience other household stressors.

The self-assembly of the amyloid β 42 (Aβ42) peptide is linked to Alzheimer's disease, and oligomeric intermediates are linked to neuronal cell death during the pathology of the disease. These oligomers are produced prolifically during secondary nucleation, by which the aggregation of monomers is catalyzed on fibril surfaces. Significant progress has been made in understanding the aggregation mechanism of Aβ42; still, a detailed molecular-level understanding of secondary nucleation is lacking. Here, we explore the role of four hydrophobic residues on the unstructured N-terminal region of Aβ42 in secondary nucleation. We create eight mutants with single substitutions at one of the four positions─Ala2, Phe4, Tyr10, and Val12─to decrease the hydrophobicity at respective positions (A2T, A2S, F4A, F4S, Y10A, Y10S, V12A, and V12S) and one mutant (Y10F) to remove the polar nature of Tyr10. Kinetic analyses of aggregation data reveal that the hydrophobicity at the N-terminal region of Aβ42, especially at positions 10 and 12, affects the rate of fibril mass generated via secondary nucleation. Cryo-electron micrographs reveal that most of the mutants with lower hydrophobicity form fibrils that are markedly longer than WT Aβ42, in line with the reduced secondary nucleation rates for these peptides. The dominance of secondary nucleation, however, is still retained in the aggregation mechanism of these mutants because the rate of primary nucleation is even more reduced. This highlights that secondary nucleation is a general phenomenon that is not dependent on any one particular feature of the peptide and is rather robust to sequence perturbations.

Powder bed fusion (PBF) applies to various metallic materials used in the metal printing process of building a wide range of complex parts compared to other AM technologies. PBF process has several variants such as DMLS (direct metal laser sintering), EBM (electron beam melting), SHS (selective heat sintering), SLM (selective laser melting), and SLS (selective laser sintering). For PBF to reach its maximum potential, machine learning (ML) algorithms are used with suitable materials to achieve goals cost-effectively. Various applications of neural networks, including ANNs, CNNs, RNNs, and other popular techniques such as KNN, SVM, and GP were reviewed, and future challenges were discussed. Some special-purpose algorithms were listed as follows: GAN, SeDANN, SCNN, K-means, PCA, etc. This review presents the evolution, current status, challenges, and prospects of these technologies in terms of material, features, process parameters, applications, advantages, disadvantages, etc., to explain their significance and provide an in-depth understanding of the same.

When it comes to food and fiber production, flaxseed (Linum usitatissimum) has been around the longest. Oil makes up over 41% of a flaxseed's total weight; of that, more than 70% is polyunsaturated. Protein, dietary fiber, α-linolenic acid (ALA), flaxseed gum, and many other beneficial compounds are abundant in flaxseed meal (FSM). There is as much as 30% crude protein in FSM. Therefore, FSM can serve as a source of excellent protein for livestock. FSM increases the efficiency and effectiveness of livestock and poultry farming. FSM can be used as an essential protein feed component in cattle and poultry farming, boosting production and profitability. Because it contains anti-nutritional ingredients such as cyanogenic glycosides, tannins, phytic acid, oxalic acid and an anti-vitamin B6 factor, the use of FSM in livestock and poultry diets is restricted. Animal nutritionists have recently shown a growing interest in reducing anti-nutritional elements and boosting FSM's nutritional value. Recently, fermented FSM has been used to feed cattle and poultry; hence its dietary benefits have not yet been fully assessed. The present article, therefore, addresses the chemical make-up, bioactive components, anti-nutritional aspects, and positive impacts of FSM in livestock and poultry production.

Milk and milk derivatives are widely consumed because of their high nutritional density. Donkey milk and milk products have been consumed since ancient times. The use of donkey milk in the human diet is gaining popularity. The abundance of antibacterial components and protective elements in donkey milk sets it apart from the milk of other animals. Like human milk, donkey milk has low fat, high lactose, and low casein/whey protein ratio. Donkey milk whey protein's anti-proliferative properties imply lung cancer treatment. Alpha-lactalbumin, a type of protein, has been found to have antiviral, anticancer, and anti-stress properties. Donkey milk, like human milk, includes a low amount of casein and a smaller quantity of beta-lactoglobulin than cow milk. Donkey milk is an alternative for newborns with cow milk protein allergy and lactose intolerance since it has a higher amount of lactose, improves palatability, and prevents allergies. Osteogenesis, arteriosclerosis therapy, cardiac rehabilitation, accelerated aging, and hypocholesterolemic diets are some areas where donkey milk is beneficial. Since it contains probiotic lactobacilli strains, fermented beverages can be made with donkey milk. Donkey milk moisturizes skin due to its high vitamin, mineral, and polyunsaturated fatty acid content. The chemical makeup and potential therapeutic benefits of donkey milk warrant additional research. This has led to a rise in interest in producing dairy goods derived from donkey milk. Donkey milk has been used to make cheese, ice cream, milk powder, and even some experimental useful fermented drinks. The present article summarises what we know about donkey milk's chemical makeup, biological functions, nutritional worth, and possible human health benefits.

Euphorbia milii Des Moul is a deciduous bush indigenous to Madagascar. The present study aims to investigate the presence of the phytochemical, in-vitro antioxidant and antimicrobial potency, and in-silico computational analysis of ethanolic and aqueous preparations of E. milii leaves and flowers. The ethanolic and aqueous extracts were tested for in-vitro antioxidant activity by DPPH, H2O2, TAC, and FRAP assay. In addition, antimicrobial potentials were assayed by agar well diffusion technique against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Candida albicans for various clinical isolates. The qualitative phytochemical analysis results confirmed the existence of alkaloids, flavonoids, phenolics, and tannins. The quantitative analysis elicits the availability of a magnificent number of alkaloids, flavonoids, phenolics, flavonols, and tannins. Among all the extracts, aqueous extracts of leaves exhibited potent antioxidant activity in DPPH, FRAP, and H2O2 assay with the IC50 value of 30.70, 60.05, and 82.92µg/mL, respectively. In agar well diffusion assay, all extracts displayed zone of inhibition varies from 2-24mm at different concentrations ranging from 10-320 mg/mL, whereas no activity was observed against Candida albicans. Furthermore, docking-based computational analysis has revealed that beta-sitosterol and taraxerol are the plant's active constituents responsible for their antimicrobial and antioxidant activities. Research findings suggest that the E. milii plant has an excellent prospect for further study for its extended antioxidative and antimicrobial potential. It could be a natural source of various ailments and can be utilized to develop new drugs.

Diperiodatocuprate [DPC (III)] was selected to predict the kinetic studies for carbenicillin (CRBC) oxidation in the basic media. The investigation was completed in the presence of CoCl3 as a catalyst by using a UV/Visible spectrophotometer at 298K temperature and 0.01 mol-dm-3 ionic strength confirming a 1:4 stoichiometry between CRBC and DPC (III). Both spectral and elemental analysis was used to identify the final products. Monoperiodatocuperate [MPC (III)] was found to be the primary active species of DPC (III). Pseudo-first order reaction was declared for DPC (III), while fractional order reactions were noticed in the case of CRBC (substrate), Co (III) catalyst as well as KOH (alkali). However, the reaction was determined to be in negative fractional order for periodate. Spectral evidence, determination of various rate constants, and both activation, as well as thermodynamic parameters, were used to predict plausible mechanisms.

The two new novel heteroleptic complexes of the type [M(II)L1.L2] (M= Zr(II) & Pd(II), L1= oxytetracycline (Otc), and L2=salicylaldehyde (Sal)) have been synthesized and analyzed by physical measurements such as CHN, pH, and conductivity. The conductivity data revealed the electrolytic nature of Pd(II)Otc/Sal and the non-electrolytic nature of the Zr(II)Otc/Sal metal complex of mixed ligand. The structural characterizations of the metal complex were approved by spectroscopic analysis methods, such as IR, 1H & 13C-NMR, UV/ Visible, and ESI-MS studies. Thermal analysis (TGA/DTA) determines the thermal and kinetic stabilities of the metal complexes using a popular Coats-Redfern equation through which the activation parameters can be calculated easily. SEM can determine the surface morphology of metal complexes. The selected bond lengths, bond angles, final optimized energy, and geometry of complexes were obtained by running an optimization task in the 3D molecular modeling software program via Chem 3D Pro. 12.0.2. The final geometrical energy was found to be 921.7712 for Zr(II)Otc/Sal and 914.6006 Kcal/mol for Pd(II)Otc/Sal complexes. Based on the above study, Zr(II)Otc/Sal complex has tetrahedral geometry and the Pd(II)Otc/Sal complex has square planar geometry. The complexes were tested in vitro for antibacterial susceptibility study against various strains of clinical pathogenic bacteria such as Staphylococcus aureus (Gram-positive), Proteus mirabilis, and Escherichia coli (Gram-negative). For the antibacterial study, the Kirby-Bauer paper disc diffusion technique is applied by using 50, 25, and 12.5 μg/μL concentrations of the metal complex. Good antibacterial sensitivity was found against all tested pathogens in all synthesized complexes.

This study was conducted to investigate the hydrochemical characteristics and water quality of Phewa lake Pokhara. Water samples were collected and major hydrochemical features were analyzed viz., Transparency, pH, electrical conductivity (EC), total dissolved solids (TDS), total alkalinity (TA), total hardness(TH), dissolved oxygen (DO), microbial analysis (MA), nitrate (NO3¯), phosphate (PO43¯), ammonia(NH3), sulfate (SO42¯), chloride(Cl¯), iron(Fe2+/Fe3+), phosphorus (P) and dissolved solids (DS). The obtained values of the hydrochemical characteristic of lake water have been compared with the world health organization (WHO). The presence of phosphate concentration and the hardness in Phewa lake is higher than the WHO value indicating the problem of rapid eutrophication. This indicates that Phewa lake water has more magnesium and calcium soluble salt. Thus, the rapid eutrophication and higher concentration of organic matter could be a serious problem for lake sustainability. Various types of natural and anthropogenic activities like agricultural runoff, urbanization, discharge of domestic sewage, solid waste dump, and industrial effluent are the major problem for lake sustainability.

Background: Eclampsia is a life threatening emergency that continues to be a major cause of maternal and perinatal mortality. The present study was undertaken to analyse the maternal and fetal outcome in patients of eclampsia and to evaluate various factors influencing this outcome. Methods: A retrospective observational epidemiological study was undertaken in the Department of Obstetrics and Gynecology, Mysore Medical College and Research Institute, Mysore, for a period of three years from January 2020 to December 2022. All women who presented as eclampsia or developed eclampsia during hospital stay were included in the study. Data analysed included various maternal parameters, fetal parameters, and the outcome of pregnancy. Results: The incidence of eclampsia was 7.14% which is relatively high, attributing to the fact that being tertiary care centre many cases are referred. Higher incidence seen in primigravida (72.4%) and low maternal age (48%). Caesarean section was indicated in 50% deliveries indicating immediate action was necessary for better fetomaternal outcome. 58.6% had an uneventful maternal outcome.There was 7.65% maternal mortality most common cause of death was intracranial hemorrhage. 53% were preterm deliveries and 29.4% stillbirths, respiratory distress in the newborn was seen as the major complication (41.9%). Conclusions: In our study, maternal complications were recorded in 41.3% of the patients with a case fatality rate of 7.65%. Respiratory distress, prematurity, growth restriction and low birth weight are the neonatal complications to be anticipated. We infer from our study that better antenatal care, early recognition of disease, timely referral, early initiation of treatment and termination of pregnancy in eclamptic women could improve maternal and fetal outcome.

Background: Bacterial meningitis is a significant cause of mortality and morbidity in children worldwide. C-reactive protein (CRP) raises rapidly in the first 24-48 hours of occurrence of bacterial meningitis and in large incremental increases thereafter. The present study was undertaken to find out the correlation between cerebrospinal fluid (CSF)-CRP and bacterial meningitis in paediatric age group. Methods: A total 123 children aged between 1 month to 12 years, in whom meningitis was suspected during the study period were included. Lumbar puncture performed at L3-L4 and CSF sample not more than 3 ml collected in 4 sterile containers. 1ml sent for protein and sugar, 0.5ml each sent for CSF cytology and CSF-CRP, 1ml sent for CSF culture sensitivity and gram staining. Results: The institutional incidence of bacterial meningitis was 3.37%. Fever (93.26%) and altered sensorium (92.30%), were the commonest symptoms and neck rigidity (58.65%) was the commonest meningeal sign. The neurologic assessment showed abnormal mental status (34.61%), abnormal cranial nerve findings (10.57%) and abnormal motor function (13.46%). The mean CRP level was 15.36±0.67 mg/l. Pneumococcus was the commonest isolated organism (53.48%) in CSF culture. The institutional mortality was 13.46%. CSF-CRP was positive in 104 (82.69%) of the culture-positive cases with a sensitivity of 82.69%, specificity 84.21%, positive predictive value 96.62% and negative predictive value of 47.05%. Conclusions: CRP levels in CSF offers a moderate sensitivity and specificity as well as high positive predictive value. This indicates that CSF-CRP is a better marker in differentiating bacterial meningitis and it can serve as a useful screening test for bacterial meningitis.