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The SARS-CoV-2 pandemic has unveiled the importance of stakeholders and ordinary citizens in managing infectious disease emergencies. Efficient management of infectious diseases requires a top-down approach which must be complemented with a bottom-up response to be effective. Here we investigate a novel approach to surveillance for transboundary animal diseases using African Swine fever as a model. We were able to collect data at a population level on information-seeking behavior and at a local level through a targeted questionnaire-based survey to relevant stakeholders such as farmers and veterinary authorities. Our study shows how information-seeking behavior and resulting public attention during an epidemic, can be addressed through novel data streams from digital platforms such as Wikipedia. We also bring evidence on how field surveys aimed at local workers (e.g. farmers) and public authorities remain a crucial tool to assess more in-depth preparedness and awareness among front-line actors. We conclude that they should be used in combination to maximize the outcome of surveillance and prevention activities for selected transboundary animal diseases.

The RFX-mod Reversed Field Pinch device passive boundary is being improved: - Drastic reduction of resistivity of first shell surrounding the plasma; - Reduction of plasma-stabilizing conductor distance from b/a=1.11 to b/a=1.04. The RFX-mod core upgrades consist of: - Removal of Inconel vacuum vessel; - Modification of the stainless steel Support Structure to ensure Vacuum Tightness (VTSS); - Modification of the copper Passive Stabilizing Shell (PSS); - Installation of upgraded sensors inside the vacuum vessel. Initial main points of investigation in the new device are discussed.

To reach fusion conditions and control the plasma configuration in ITER, the next step in tokamak fusion research, two neutral beam injectors (NBIs) will supply 17MW each, by neutralizing accelerated negative hydrogen or deuterium ions. The requirements of ITER NBIs (40A/1MeV D- ions for

The ITER Neutral Beam Test Facility (NBTF) in Padova (Italy) hosts two different experiments: SPIDER, the prototype of the ion source of ITER Neutral Beam Injector (NBI) and MITICA, the prototype of the ITER NBI. The ion sources of SPIDER and MITICA are driven by Radio-Frequency (RF) power, for a total of 800kW at 1MHz. The RF power is delivered to the Inductively Coupled Plasma (ICP) drivers of the ion source by four tetrode oscillators through four RF circuits, each one consisting of a coaxial transmission line and a capacitive matching network. During SPIDER experimental campaign, the circulation of RF Stray Currents in the electric system has been pointed out. These currents hinder the correct operation of the system, thus preventing to achieve the full performances due to the excessive overheating of its components. To have a better comprehension of the issue, after an overall circuital investigation and the identification of a possible reclosing path for the RF Stray Currents, a simplified model of SPIDER electric system was developed, initially focusing on a single RF generator. The aim of the work presented in this paper is to upgrade this model, through a step-by-step procedure, by adding the other three RF oscillators, and their related RF circuits, in order to model a more complete version of the electric system of SPIDER. This upgraded model will allow increasing the knowledge of the issue and, in particular, understanding the impact of the four RF oscillators on the RF Stray Currents, also thanks to the support of the SPIDER's experimental results. After that, the task is trying to apply this model also to the MITICA ion source RF circuit in order to try predicting and, if possible, limiting the circulation of the RF Stray Currents during future MITICA operations.

At the ITER Neutral Beam Test Facility in Padua (Italy), the ion source full scale prototype SPIDER has been in operation since June 2018. SPIDER is designed for an acceleration voltage of -100 kV, however early operation has taken place with a limit of -30 kV. As of March 2021, the limitation has been lifted and the experiment begun to explore the range of beam energies exceeding 30 keV. This has revealed a number of novel issues with the power supplies of ion source and extractor, mainly associated to grid breakdowns. Those power supplies include a set of high current single quadrant resonant converters, known as Source Support power supplies and a high voltage pulse step modulator feeding the extraction gap. The Source support power supplies perform a variety of functions, ranging from providing magnetic filter field current to polarising electrodes for minimization of the co-extracted electrons, from heating of the filaments to polarising the magnetic cores for protection from grid breakdowns. The Extraction Grid power supply extracts a negative ion and electron beam from the source, by applying a high voltage down to -12 kV dc to the gap between Plasma Grid and Extraction Grid. Grid breakdowns at beam energies exceeding 30 keV have shown the capability to upset the output measurements of the Source Support power supplies, limiting operation and reducing reliability of the whole system. The paper describes work undertaken firstly to identify the issues, found to belong to two distinct categories, general failures of all Source Support power supplies measurements and trips from the output voltage measurements of a well-defined subset of power supplies. Further investigation has associated the events to specific experimental conditions, pointing out weak points of the design and suggesting remedial actions. A number of modifications could be deployed quickly and tested in June 2021, before the stop to SPIDER operation for a planned major shutdown. The results of those tests are reported, along with the plan of future modifications for achieving immunity of the Source Support power supplies to the adverse effects of grid breakdowns at full acceleration voltage.

Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the literature for evidence of human infection with animal influenza viruses by diagnostic methods used. The review covering Medline, Embase, SciSearch and CabAbstracts yielded 6,955 articles, of which we retained 89; for influenza A(H5N1) and A(H7N9), the official case counts of the World Health Organization were used. An additional 30 studies were included by scanning the reference lists. Here, we present the findings for confirmed infections with virological evidence. We found reports of 1,419 naturally infected human cases, of which 648 were associated with avian influenza virus (AIV) A(H5N1), 375 with other AIV subtypes, and 396 with swine influenza virus (SIV). Human cases naturally infected with AIV spanned haemagglutinin subtypes H5, H6, H7, H9 and H10. SIV cases were associated with endemic SIV of H1 and H3 subtype descending from North American and Eurasian SIV lineages and various reassortants thereof. Direct exposure to birds or swine was the most likely source of infection for the cases with available information on exposure.

ITER envisages the use of two heating neutral beam injectors plus an optional one as part of the auxiliary heating and current drive system, to reach the desired performances during its various phases of operation. The 16.5 MW expected neutral beam power per injector is several notches higher than worldwide existing facilities.In order to enable such development, a Neutral Beam Test Facility (NBTF) was established at Consorzio RFX, exploiting the synergy of two test beds, called SPIDER and MITICA. SPIDER is dedicated developing and char-acterizing large efficient negative ion sources at relevant parameters in ITER-like conditions: source and accel-erator located in the same vacuum where the beam propagates, immunity to electromagnetic interferences of multiple radio-frequency (RF) antennas, avoidance of RF-induced discharges on the outside of the source. Three years of experiments on SPIDER have addressed to the necessary design modifications to enable full perfor-mances. The source is presently under a long shut-down phase to incorporate learnings from the experimental campaign, in particular events/issues occurred during operation, which led to the identification of improvement opportunities/necessities (e.g. RF discharges, local burns, water leaks, other damages, configuration/design upgrades to maximize chances/margin to quest target parameters).Parallelly, developments on MITICA, the full-scale prototype of the ITER Neutral Beam Injector (NBI) featuring a 1 MV accelerator and ion neutralization, are underway including manufacturing of the beam source, accel-erator and the beam line components, while power supplies and auxiliary plants, already installed, are under final testing and commissioning.Integration, commissioning and tests of the 1 MV power supplies are essential for this first-of-kind system, unparalleled both in research and industry field. 1.2 MV dc insulating tests of high voltage components were successfully completed. The integrated test to confirm 1 MV output by combining invertor systems, DC gener-ators and transmission lines extracted errors/accidents in some components. To realize a concrete system for ITER, said events have been addressed and solutions for the repair and the improvement of the system were developed.Hence, NBTF is emerging as a necessary facility, due to the large gap with existing injectors, effectively dedicated to identify issues and find solutions to enable successful ITER NBI operations in a time bound fashion. The lessons learned during the implementation on NBTF and future perspectives are here discussed.

We document new facts about risk in male wages and earnings, household earnings, and pre- and post-tax income in the Netherlands and the United States. We find that, in both countries, earnings display important deviations from the typical assumptions of linearity and normality. Individual-level male wage and earnings risk is relatively high at the beginning and end of the working life, and for those in the lower and upper parts of the income distribution. Hours are the main driver of the negative skewness and, to a lesser extent, the high kurtosis of earnings changes. Even though we find no evidence of added-worker effects, the presence of spousal earnings reduces the variability of household income compared to that of male earnings. In the Netherlands, government transfers are a major source of insurance, substantially reducing the standard deviation, negative skewness, and kurtosis of income changes. In the U.S. the role of family insurance is much larger than in the Netherlands. Family and government insurance reduce, but do not eliminate non-linearities in household disposable income by age and previous earnings in either country.

De Nardi, M, Pizzigalli, L, Benis, R, Caffaro, F, and Cremasco, MM. Acute effects of partial-body cryotherapy on isometric strength: maximum handgrip strength evaluation. J Strength Cond Res 31(12): 3497-3502, 2017-The aim of the study was to evaluate the influence of a single partial-body cryotherapy (PBC) session on the maximum handgrip strength (JAMAR Hydraulic Hand dynamometer). Two hundred healthy adults were randomized into a PBC group and a control group (50 men and 50 women in each group). After the initial handgrip strength test (T0), the experimental group performed a 150-second session of PBC (temperature range between -130 and -160° C), whereas the control group stayed in a thermo neutral room (22.0 ± 0.5° C). Immediately after, both groups performed another handgrip strength test (T1). Data underlined that both groups showed an increase in handgrip strength values, especially the experimental group (Control: T0 = 39.48 kg, T1 = 40.01 kg; PBC: T0 = 39.61 kg, T1 = 41.34 kg). The analysis also reported a statistical effect related to gender (F = 491.99, P ≤ 0.05), with women showing lower handgrip strength values compared with men (women = 30.43 kg, men = 52.27 kg). Findings provide the first evidence that a single session of PBC leads to the improvement of muscle strength in healthy people. The results of the study imply that PBC could be performed also before a training session or a sport competition, to increase hand isometric strength.

Earnings dynamics are much richer than typically assumed in macro models with heterogeneous agents. This holds for individual-pre-tax and household-post-tax earnings and across administrative (Social Security Administration) and survey (Panel Study of Income Dynamics) data. We study the implications of two processes for household, post-tax earnings in a standard life-cycle model: a canonical earnings process (that includes a persistent and a transitory shock) and a rich earnings dynamics process (that allows for age-dependence of moments, non-normality, and nonlinearity in previous earnings and age). Allowing for richer earnings dynamics implies a substantially better fit of the evolution of cross-sectional consumption inequality over the life cycle and of the individual-level degree of consumption insurance against persistent earnings shocks. Richer earnings dynamics also imply lower welfare costs of earnings risk, but, as the canonical earnings process, do not generate enough concentration at the upper tail of the wealth distribution.