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A lo largo de la historia, diversas han sido las funciones sociales que ha desarrollado el cine más allá de sus faceta lúdica basada en el entretenimiento. Entre estas funciones destacan su capacidad para registrar hechos históricos fundamentales, su gran eficacia como herramienta de publicidad o propaganda, su facultad a la hora de interactuar con otras disciplinas artísticas, su capacidad de educar y sensibilizar a la sociedad, su facultad ética o filosófica o su faceta informativa.

El medio fílmico ha sufrido diferentes desarrollos tecnológicos que le han permitido cumplir las expectativas del exigente espectador. Además, muchos han sido los movimientos cinematográficos que han llevado a la crítica especializada a la catalogación de los diferentes realizadores. La línea divisoria entre autoría y comercialidad es cada vez más desgalda. El género de la ciencia ficción se ha posicionado como el de mayor atractivo en la actual sociedad contemporánea. En este contexto, este trabajo de investigación propone un análisis de aspectos esenciales del Universo Cinematográfico de Marvel el cual permita desdibujar la mencionada línea mediante una nueva identidad de autoría comercial.

Electromagnetic coupling is the mechanism by which one circuit induces noise or interference in another adjacent circuit. This coupling mechanism generates Electromagnetic Interferences that degrade or even interrupt the operation of adjacent circuits. However, it is often rare in the academic and professional fields of power electronics to have sufficient knowledge to identify and address this problem. Therefore, intuition plays an important role in anticipating and dealing with this problem. This article describes the basic principles of this coupling mechanism and proposes simple solutions to this electromagnetic interference problem. These solutions must be applied right from the design phase of any electronic equipment. The problem described and its solutions are experimentally validated in a simple test circuit. This article is mainly oriented to the academic and professional field of power electronics and aims to describe in a simple and experimental way the problems associated with inductive coupling.

Low back pain is a public health problem due to its high prevalence and burden of the disease. This study aimed to determine the characteristics of patients with low back pain treated at the Centro de Salud N1 from Ibarra, between January 2017 and November 2020. Two-thousand fifty-five consultations for low back pain were included, observing an increase during the study period, except for 2020 (53.78% fewer consultations than 2019). Consultation for low back pain was more frequent in women than men (64.18% vs 35.82%; z-score 12.87, p

Este trabajo realizamos un análisis descriptivo del desarrollo histórico conceptual del paisaje sonoro. El objetivo es identificar la manera en que se ha construido un campo de estudio alrededor de dicha propuesta. Se desarrolló una búsqueda selectiva de literatura que tuvo como punto de partida textos clave de Murray Schafer y del World Soundscape Project, a partir de los cuales se rastreó su influencia en distintas partes del mundo. Se identificó un periodo de expansión durante la década de 1980, en el cual se conformaron sus dos enfoques principales: el ecológico y el perceptual-cultural. Así mismo, se hizo énfasis en la manera en que fue abordado dicho término desde enfoques culturalistas en geografía y se identificó que a partir de las discusiones hechas surgieron como propuesta las geografías auditivas y del sonido. Finalmente, se realizó una revisión sistemática en índices y buscadores de literatura académica y se encontró un interés latente, durante los últimos tres lustros, por incorporar el sonido como objetivo de estudio a partir de alguna de las posturas mencionadas (paisaje sonoro, geografías auditivas y geografías del sonido), sin embargo, es un tema que continúa en proceso de consolidación.

Neuromusculoskeletal diseases represent a key demand on the healthcare system and society, due to the fact that their symptoms require continuous care and monitoring, especially considering the ongoing demographic ageing trend. Nowadays, around 2% of the population in Spain suffers from one of these diseases. However, some of them are estimated to grow fourfold in the next 50 years. Added to this trend, is a relevant problem on disease-masking effects linked to the natural ageing process on these diseases and their consequences.Fortunately, the emergence and spreading of innovative technologies and infrastructures in the healthcare context is making it possible to promote the evolution of the health care model from intensive care to prevention. This new approach aims to empower the population as a key agent in managing, monitoring and guiding the processes that promote self-care, as the backbone of the real and effective development and deployment of so-called personalised medicine.Cutting-edge technologies offer the possibility of gathering continuous objective patient information, including Real World Data, being able to identify, at an early stage, any sign/symptom that may generate a risk or accelerate decline, and carry out an early personalised intervention to improve or extend quality of life. To this end, IBERUS is tackling the use of biomechanical assessment and smart health technologies that enable data gathering to apply Artificial Intelligence underpinned on a Big Data scalable architecture to:- Provide new evidence on innovative indicators for clinical assessment,- Develop cutting-edge technologies to provide a functional characterisation and monitoring of people both in clinical settings and in their daily-life scenarios, as ell as making possible to generate real-time responses of the assessment algorithms in rehabilitation,- Define new criteria and methods for clinical decision support in treatment and rehabilitation,- Applying third-generation Artificial Intelligence techniques integrating synthetic data and images of neuromusculoskeletal pathologies,- Effectively share and manage Smart Health Data for the prognosis, treatment and care of neuromusculoskeletal pathologies, through innovative technologies based on the recording, integration, interoperability and advance data exploitation.- Physicians and expert researchers will have an active involvement both at co-design and co-validation phases of several innovative high-impact solutions at a clinical and professional level.As a result, emerging digital tools, innovative technical architectures and expert knowledge will be provided to improve clinical care and integrated care through new products and services for the diagnosis, rehabilitation, treatment and care of degenerative diseases of the neuromusculoskeletal system in clinical and out-of-hospital settings. Funding: IBERUS CERVERA Network of Excellence Project (CER-20211003) is funded by the Ministry of Science and Innovation through the Centre for the Development of Industrial Technology (CDTI), under the General State Budget 2021 and the Plan for Recovery, Transformation and Resilience (Plan de Recuperación, Transformación y Resiliencia) of the Spanish Government.

Cytogenetic abnormalities (CA) such as t(4;14), t(14;16), and del(17p), are associated with a poor prognosis in Multiple Myeloma (MM) patients. However, there is scarce information regarding the Latin-American population. This study aims to analyze the impact of t(4;14), t(14;16), and del(17p) on the progression-free survival (PFS) and overall survival (OS) of transplant-eligible newly-diagnosed MM (NDMM) patients in Latin America. Retrospective survival analysis based on the Grupo de Estudio Latinoamericano de MM (GELAMM) registry, including all adult patients with NDMM harboring CA t(4;14), t(14;16), and/or del(17p). Fifty-nine patients were included; the median age was 57 years, 55.9% males, 22% ISS-I, 25.4% ISS-II, and 47.5% ISS-III. The majority (89.8%) had 1 alteration, whereas 10.2% had del(17p) and t(4;14). The frequencies of CA were del(17p) in 61.0%, t(4;14) in 25.4%, and t(14;16) in 3,4%. Autologous stem cell transplantation (ASCT) was performed in 61.0% of cases. Five-year OS for the entire cohort was 60.8% and 5-year PFS was 28.1%. Bortezomib-based induction regimen (BBR) (P = 0.029), consolidation with ASCT (P0.001), and maintenance therapy (P = 0.004) were associated with an improved 5-year OS. In the multivariate analysis, ASCT was the only variable with a positive impact on OS (HR 0.11, 95% CI 0.033 to 0.34, P0.001). The median PFS presented a non-statistically significant benefit in BBR, ASCT, and maintenance therapy groups. BBR induction, ASCT, and maintenance therapy were associated with improved OS in high-risk NDMM patients.

Con el fin de aportar al conocimiento tradicional del Pecari tajacu en la zona centro del Chocó, se realizó este estudio que ofrece información del uso popular, las formas de aprovechamiento del tatabro sin collar y la forma de entender esta actividad por parte de los pobladores de la región. Los datos se obtuvieron, a través de encuestas realizadas a personas residentes en los municipios de Quibdó, Atrato, Unión Panamericana, Cantón de San Pablo, Medio Baudó y Cértegui. Se encontraron cuatro categorías de uso, de las cuales la alimentación es la más importante, seguida del uso artesanal. Aún se conservan los métodos de cacería tradicionales siendo los más empleados el machete (25%), el perro (24%) y la escopeta (23%). El uso de la fauna silvestre está muy relacionado con el conocimiento empírico y tradicional de las comunidades locales, que considera el tatabro como una importante fuente proveedora de proteína animal; se identificó además una disminución en el tamaño de las poblaciones y una reducción en la frecuencia de captura.

Bortezomib (Velcade®) is a proteasome pathway inhibitor that has improved multiple myeloma (MM) overall survival. Bortezomib-induced peripheral neuropathy (BIPN) is a frequent adverse event, requiring delay, dose reduction or cessation of therapy. Although most of the symptoms resolve after discontinuation or dose-reduction, almost 25% develop chronic symptoms, affecting quality of life and limiting the therapeutic choices. There is limited evidence regarding the strategies to prevent bortezomib-induced polyneuropathy (BIPN). We conducted a review of the published data to summarize the available information regarding BIPN prevention strategies. Our search included literature published in the Cochrane Library databases, Medline/PubMed, SciELO, Google Scholar, and Trip Database in the last ten years, including observational analytic studies, experimental studies, systematic reviews, and metanalysis, which reported the efficacy of interventions to prevent BIPN. Eight studies have been included. The subcutaneous administration of bortezomib has shown a protective effect of all grades of BIPN (OR=0.40, 95% CI 0.27 to 0.59, p 30 mg/m2 is significantly associated with a higher risk of BIPN. Other therapies as Acetyl-l-carnitine (ALC), dexamethasone in partnered dosing (day of/after bortezomib), high-dose intravenous mecobalamin (HDIME), and the combination of docosahexaenoic acid, α-lipoic acid, vitamin C 60 mg, and vitamin E have been assessed but their efficacy for BIPN prevention has not been confirmed. We conclude that the subcutaneous route of administration of bortezomib effectively prevents BIPN while other strategies lack robust evidence to be recommended.

The measurement of fast voltage and current transients of Silicon Carbide (SiC) devices requires high bandwidth (BW) probes. Commercially available voltage and current probes can be expensive, and, in addition, the delay introduced by them must be compensated to achieve a proper time alignment (de-skew). Determining this de-skewing value is not a trivial task. In this paper, a simple and affordable measurement method is presented for the simultaneous measurement of the voltage and current transients of SiC devices. The voltage is measured by means of a high BW RC attenuator, while the current is estimated from the voltage drop in the stray inductance of the switching loop. Since both voltages are measured with two equal and matched high BW passive voltage probes, there is no need to apply any de-skew. This is one of the most important advantages of the method. The presented method is experimentally evaluated and used for the estimation of energy switching losses in the tested SiC- mosfet .

Introduction Bortezomib is proteasome inhibitor used in multiple myeloma treatment. The reactivation of herpes simplex virus (HSV) and varicella-zoster virus (VZV) during bortezomib-based therapy is a well-known adverse event. Antiviral prophylaxis is mandatory. Nevertheless, reports of herpesviral encephalitis are scarce. Case report A 57-year-old multiple myeloma patient who during CyBorD protocol (Bortezomib, cyclophosphamide, and dexamethasone), after a transient suspension of antiviral prophylaxis presented progressive headaches unresponsive to conventional analgesics, asthenia, fever, episodic visual hallucinations, and vesicular lesions in the right supraorbital and frontal region. Herpetic encephalitis was diagnosed after detecting herpes zoster in cerebrospinal fluid. Management & Outcome The patient was treated with acyclovir 500mg every 6 hours for 21 days, and subsequent valacyclovir prophylaxis achieving an excellent clinical evolution. Anti-myeloma treatment was changed to lenalidomide and dexamethasone achieving a durable complete response. Herpesviral encephalitis is a rare but severe complication associated with the use of Bortezomib, especially when patients did not receive acyclovir prophylaxis. However, a rapid detection based on the clinical suspicion, and the prompt start of treatment, may lead to overcome this adverse event.

We investigate how similar heatmaps of soccer players are when constructed from (i) event datasets and (ii) tracking datasets. When using event datasets, we show that the scale at which the events are grouped strongly influences the correlation with the tracking heatmaps. Furthermore, there is an optimal scale at which the correlation between event and tracking heatmaps is the highest. However, even at the optimal scale, correlations between both approaches are moderate. Furthermore, there is high heterogeneity in the players' correlation, ranging from negative values to correlations close to the unity. We show that the number of events performed by a player does not crucially determine the level of correlation between both heatmaps. Finally, we analyzed the influence of the player position, showing that defenders are the players with the highest correlations while forwards have the lowest., Comment: 6 pages, 5 figures

In this study, we analyse the proximity between professional players during a soccer match. Specifically, we are concerned about the time a player remains at a distance to a rival that is closer than 2 m, which has a series of consequences, from the risk of contagion during a soccer match to the understanding of the tactical performance of players during the attacking/defensive phases. Departing from a dataset containing the Euclidean positions of all players during 60 matches of the Spanish national league (30 from LaLiga Santander and 30 from LaLiga Smartbank, respectively, the first and second divisions), we analysed 1,670 participations of elite soccer players. Our results show a high heterogeneity of both the player-player interaction time (from 0 to 14 min) and the aggregated time with all opponents (from

Dear editor, This letter is in response to Chaudhary, Shrestha, and Pathak, who highlighted various aspects of our previous manuscript "Prevalence of Anaemia in Children Diagnosed with Pneumonia in a Tertiary Hospital in Quito, Ecuador." I want to respond to each point referred to in a similar extension as used by the authors. We agreed on the fact that it is prompt to conclude in nutritional deficiencies as a risk factor to suffer pneumonia in Ecuadorian children that is why we express this conclusion as a possibility. Nevertheless, as evidenced in the meta-analysis presented by Jackson et al., the Odds Ratio (OR) meta-estimate for under nutrition as a risk factor for acute lower respiratory infections was 4.5 (95% CI 2.1-9.5)1. To add, in the same paper, the OR meta-estimate for anaemia, vitamin D deficiency, and zinc supplementation, was 3.9 (95% CI 2.4-6.3), 7.3 (95% CI 2.5 to 21.5), and 0.5 (95% CI 0.3 to 0.9), respectively 1. Moreover, in a study conducted in Malawi including 9 533 children, severe malnutrition and moderate malnutrition were associated not only with a pneumonia risk but with an increased risk of inpatient mortality, with Odds Ratios (OR) of 4.63 (3.08, 6.97) and 1.73 (1.21, 2.48) respectively. Therefore, there is supporting evidence globally of the suggested risk 2. I am glad that the authors in the letter bring to the table a discussion of pneumonia diagnosis. In our study, the evaluation of pneumonia started with the clinical assessment including parameters with an acceptable sensitivity (Sen%) or specificity (Spe%), such as; fever on examination (Sen% 47, Spe% 68), history of fever (Sen% 92, Spe% 21), tachypnoea (Sen% 13, Spe% 95), rhonchi (Sen% 26, Spe% 98), crackles (Sen% 43, Spe% 73), wheezing (Sen% 4, Spe% 98) (3). However, as referred to in the original paper, the evaluation was not limited to these factors "Hypoxemia, defined as a sustained saturation of peripheral oxygen (SpO2)

El mieloma múltiple (MM) es una neoplasia hematológica clasificada por la Organización Mundial de la Salud (OMS) dentro de las enfermedades linfoproliferativas de células B y se caracteriza por la proliferación de células plasmáticas monoclonales, junto a la producción excesiva de inmunoglobulinas no funcionales o cadenas ligeras de inmunoglobulina [1].

Resumen Introducción: la anemia y ferropenia son condiciones muy prevalentes en hemodiálisis asociadas al incremento en la morbimortalidad. Objetivo: describir las características de la ferropenia y anemia de pacientes con enfermedad renal terminal en hemodiálisis, y analizar los parámetros del hemograma para predecir la deficiencia de hierro en ellos. Materiales y métodos: estudio descriptivo transversal realizado en la unidad de hemodiálisis del Hospital de Especialidades de las Fuerzas Armadas N°1 y CLINEF Norte, Quito, Ecuador, durante diciembre de 2018 y enero de 2019. El análisis se basó en la comparación de dos grupos, pacientes ferropénicos y no ferropénicos. Resultados: se incluyeron 268 pacientes con edad promedio de 16 y 59 años; 89 pacientes (33,21 %) fueron ferropénicos, sin embargo presentaron parámetros hematimétricos normales en la mayoría de ellos. Encontramos además que el 80,22 % de los pacientes incluidos eran anémicos, con poca frecuencia de microcitosis e hipocromía. Entre ellos, el 33,21 % fueron ferropénicos, siendo la hemoglobina un pobre marcador de ferropenia. Adicionalmente, para predecir ferropenia, y de no contar con ferritina o saturación de transferrina, encontramos útil la hemoglobina corpuscular media, el volumen corpuscular medio, el ancho de distribución eritrocitaria y el índice de Srivastava, sin embargo el valor predictivo se incrementó al incluir la sideremia como en nuestro modelo propuesto. Conclusiones: dada la alta frecuencia de anemia sin hipocromía o microcitosis en los pacientes con enfermedad renal terminal en hemodiálisis, incluso en ferropenia, es fundamental la evaluación regular del metabolismo férrico, así como el análisis del hemograma con enfoque en el paciente dialítico. Abstract Introduction: Anemia and iron deficiency are very prevalent conditions in hemodialysis and have been associated with an increase in morbidity and mortality. Objective: Describe the characteristics of iron deficiency and anemia in patients with end-stage renal disease on hemodialysis, and analyze the parameters of the blood count to predict iron deficiency in them. Materials and methods: A cross-sectional descriptive study carried out in the hemodialysis unit of the Specialties Hospital of the Armed Forces No. 1 and CLINEF Norte, Quito, Ecuador, during December 2018 and January 2019. The analysis was based on the comparison of two groups, ferropenic and non-ferropenic patients. Results: We included 268 patients with an average age of 59.16 years; 89 patients (33.21%) were ferropenic. However, they presented normal hematimetric parameters in most of them. We also found that 80.22% of the patients included were anemic, with little frequency of microcytosis and hypochromia. Among them, 33.21% were ferropenic, being hemoglobin a poor marker of iron deficiency. Additionally, to predict ferropenia, and not to have ferritin or transferrin saturation, we find especially useful the mean corpuscular hemoglobin, mean corpuscular volume, erythrocyte distribution width, and Srivastava index, however the predictive value increases when including the syderemia as in our proposed model. Conclusions: Given the high frequency of anemia without hypochromia or microcytosis in patients with end-stage renal disease on hemodialysis, even in iron deficiency, regular evaluation of ferric metabolism is essential, as well as the analysis of the blood count with a focus on the dialysis patient.

Posterior reversible encephalopathy syndrome (PRES) is a clinical–radiological disorder that may include encephalopathy, seizures, headache, and visual disturbances. It is associated with conditions that induce endothelial damage, causing vasogenic cerebral edema that can be observed in magnetic resonance scans. It occurs in

Resumen El sindrome de encefalopatia posterior reversible (PRES) es un trastorno clinico-radiologico caracterizado por encefalopatia, convulsiones, cefalea y alteraciones visuales. Se asocia a entidades que ocasionan dano endotelial, causando edema cerebral vasogenico evidente en resonancia magnetica. En pacientes con lupus eritematoso sistemico (LES) se presenta en

BACKGROUND Aging produces a deterioration in the older person and this affects the neuromuscular system among others, reducing muscle mass, strength and muscle power and this generates a decrease in functional capacity in the elderly, can cause falls and disability. OBJECTIVE The aim of this study is to analyze the ability to know the functional capacity and fall risk of elderly people in nursing homes through a novel short-test using a single inertial sensor embedded in an Android device. METHODS Study participants included 47 older people (over 55 years old) resided in two nursing homes. Functional assessment with FallSkip® which includes static balance, gait analysis, lower limb power when sit to stand, test execution time and reaction time. The patients were randomly divided into two study groups, control and experimental group. The experimental group underwent individualized rehabilitation therapy based on the results obtained by the modified Timed Up and Go falls risk test. Subsequently, the results obtained between the two residences and between the experimental groups were compared. RESULTS 70% of people in nursing homes are over 75 years old, which the female participants were mostly found in the older age groups, unlike their male counterparts, who were concentrated in the younger age groups. When comparing the anthropometric variables and clinical scales for the two nursing homes no statistically significant differences appeared (p > 0.05) only on the fall risk score (p < 0.05) and the sit to stand power (p < 0.05). CONCLUSIONS The comfort of evaluating the functional status of the elderly in the nursing homes by an objective and simple functional test has allowed us to carry out individualized rehabilitation interventions for each participant; as well as to know the functional level of the people in the nursing homes.

Background and aims. Multiple myeloma is a frequent hematologic malignancy, in which the International Stratification Score (ISS) is widely used to estimate the overall survival. However, there are no studies in Latin America evaluating its performance. This study aims to describe the ISS performance in the overall survival estimation for newly diagnosed multiple myeloma patients in Uruguay. Methods. This is a retrospective registry‐based survival analysis through the Grupo Uruguayo de Mieloma Múltiple (GUMMA) database, including newly diagnosed multiple myeloma patients from January 2001 until May 2019. Results. 249 patients were included, 51.81% males and an average age of 63.49 years. According to ISS and Durie-Salmon score (DSS), 47.79% and 82.3% were ISS III and DSS III, respectively. Also, 32.3% were DSS B. Auto hematopoietic stem cell transplantation was performed in 31.73% of patients, and bortezomib was used in 44.18% as frontline therapy. The overall survival was 80% for ISS1, 64.9% ISS2, and 48.6% ISS3 (Log-Rank; p

RESUMEN: Durante los últimos veinte años, el Centro de Arqueología Subacuática (CAS-IAPH) ha desarrollado un amplio pro-grama de documentación y recopilación de información sobre naufragios históricos en aguas andaluzas a través de los fondos de archivos públicos y privados. En la ac-tualidad, cuenta con cerca de 2.000 referencias que van a permitir la mejora del conocimiento, protección y pre-servación de ese patrimonio tan amenazado por el expo-lio. Con el fin de mejorar la eficacia de este proceso, entre 2018 y 2019, ha desarrollado, junto con el Centro PRHLT de la Universidad Politécnica de Valencia, un proyecto in-novador (el proyecto Carabela) que confirma la eficacia de las técnicas de reconocimiento de texto manuscrito (HTR) para localizar y caracterizar documentos digitales en grandes fondos de archivos sin apenas intervención humana, con el consecuente ahorro de tiempo y recursos en la investigación y/o gestión de estos fondos. ABSTRACT: The Underwater Archeology Center (IAPH) has developed, over the last 20 years, an extensive program of documen-tation and compilation of information on historical ship-wrecks in Andalusian waters through public and private archives. At present it has about 2000 references that will allow the improvement of knowledge, protection and pres-ervation of that heritage, which is so much threatened by plunder. In order to improve the efficiency of this process, between 2018 and 2019, it has developed, together with the PRHLT Center of the Polytechnic University of Valen-cia, an innovative project (Carabela Project) that confirms the effectiveness of handwritten text recognition techniques (HTR) to locate and characterize digital documents in large archives with little human intervention, with the consequent saving of time and resources in the research and / or management of these collections. RESUM: Durant els últims vint anys, el Centre d'Arqueologia Subaquàtica (CAS-IAPH) ha desenvolupat un ampli programa de documentació i recopilació d'informació sobre naufragis històrics en aigües andaluses a través dels fons d'arxius públics i privats. En l'actualitat, compta amb prop de 2.000 referències que permetran la millora del coneixement, protecció i preservació d'aquest patrimoni tan amenaçat per l'espoli. Per tal de millorar l'eficàcia d'aquest procés, entre 2018 i 2019, ha desenvolupat, juntament amb el Centre PRHLT de la Universitat Politècnica de València, un projecte innovador (el projecte Carabela) que confirma l'eficàcia de les tècniques de reconeixement de text manuscrit (HTR) per localitzar i caracteritzar documents digitals en grans fons d'arxius gairebé sense intervenció humana, amb el conseqüent estalvi de temps i recursos en la investigació i / o gestió d'aquests fons.

Silicon Carbide (SiC) MOSFETs enable enhanced performance of power converters in several applications. Parallel connection of SiC MOSFETs become mandatory for medium power applications due to the current rate of existing modules. A balanced current sharing between paralleled MOSFETs is desired to maximize the power capability of each device, maximizing the power capability of the whole system. This work studies the static current unbalance of two paralleled 1200V-400A SiC MOSFET modules with individual gate driver. Experimental measurements are done focused on parasitic inductance caused by electromechanical layout.

An increasing amount of virtual reality (VR) research is carried out\ud to support the vast number of applications across mental health,\ud exercise and entertainment fields. Often, this research involves the\ud recording of physiological measures such as heart rate recordings\ud with an electrocardiogram (ECG). One challenge is to enable remote, reliable and unobtrusive VR and heart rate data collection\ud which would allow a wider application of VR research and practice\ud in the field in future. To address the challenge, this work assessed\ud the viability of replacing standard ECG devices with a photoplethysmography (PPG) sensor that is directly integrated into a VR headset\ud over the branches of the supratrochlear vessels. The objective of\ud this study was to investigate the reliability of the PPG sensor for\ud heart-rate detection. A total of 21 participants were recruited. They\ud were asked to wear an ECG belt as ground truth and a VR headset\ud with the embedded PPG sensor. Signals from both sensors were\ud captured in free standing and sitting positions. Results showed that\ud VR headset with an integrated PPG sensor is a viable alternative\ud to an ECG for heart rate measurements in optimal conditions with\ud limited movement. Future research will extend on this finding by\ud testing it in more interactive VR settings.

Made available in DSpace on 2020-12-12T02:14:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Ministerio de Economía y Competitividad We investigated the particular organization of Guardiola's F.C. Barcelona during season 2009/2010, using datasets from the Spanish National League La Liga. Specifically, we constructed the corresponding pitch networks, obtained from all passes successfully performed by a team during a football match. Pitch networks are composed of nodes consisting of particular subdivisions of the field, which are connected through links whose weight ωi,j corresponds to the number of passes made from region i to region j. We performed a multi-scale analysis focused on evaluating the properties of pitch networks at different scales, from a partition of the pitch into 2 × 2 to 10 × 10 areas. For each scale, we calculated a diversity of network parameters of F.C. Barcelona and its opponents during the whole season. Next, we compared the properties of F.C. Barcelona pitch networks with the networks of its rivals. Our results show how, depending on the spatial scale, there are statistically significant differences between F.C. Barcelona and the rest of the teams of the Spanish league. These differences are particularly significant at the clustering coefficient, the network average shortest-path, and the number of nodes occupied by a team for partitions with a high number of subdivisions. UNESP-IFT ICTP-SAIFR Sao Paulo CeSiMo Facultad de Ingeniería Universidad de Los Andes Depto. Ingeniería Biomédica. Universidad de los Andes Complex Systems Group Universidad Rey Juan Carlos Grupo Interdisciplinar de Sistemas Complejos (GISC) Laboratory of Biological Networks Center for Biomedical Technology, Universidad Politécnica de Madrid E.S.A.D.E. Business School Departamento de Metodología F.C. Barcelona Institute of Unmanned System and Center for OPTical IMagery Analysis and Learning (OPTIMAL) Northwestern Polytechnical University UNESP-IFT ICTP-SAIFR Sao Paulo FAPESP: 2016/01343-7 FAPESP: 2017/05770-0 Ministerio de Economía y Competitividad: FIS2017-84151-P

[EN] Size, shape and posture are fundamental features of digital human models (DHM) to obtain accurate virtual simulations of the ergonomics of products and environments. Research on 3D body scanning, processing and modelling have enabled the generation of avatars representing specific populations and morphotypes in standing and seated postures being the basis to define size and shape of DHM. Posture is implemented with biomechanical models of the human movement. Most of the research is focused on posture control and movement tracking to analyze the variability in different contexts (e.g. driving, performing a working task). Motion capture technology used for this purpose, requires a limited number of sensors or reflective markers attached to the body according to the definition of body segments. 3D body scanning and motion capture are both technologies currently used to analyze human body shape and biomechanics to apply it to enhance digital human models. These technologies may converge on the so-called temporal 3D scanners or 4D scanners, a new technology recently developed to scan the body in motion. With this technology, it is possible to obtain sequences of dense 3D point clouds representing the movement of the body. In this paper, a novel methodology to create realistic 3D body models in motion is proposed. This method is supported by a new 4D scanning system (Move 4D) and a data driven-model. Move4D is a modular photogrammetry-based 4D scanning system. It consists of a set of 12 synchronized modules to scan full bodies with texture in motion. It can capture up to 180 fps with a resolution of 2 mm. The algorithms have been conceived and optimized to automatically process the series of raw point clouds captured. They rely on a data-driven body model including shape, pose and soft-tissue deformation trained with a large database and a deep learning model. The process is fully automatic and does not require any interactive landmarking or revision. The 3D outcome of this methodology is one noise-and artefact-free watertight mesh per frame and a model of shape, pose and soft-tissue that can be rigged with a 23-joint skeleton. This type of outcome permits their use for many applications such as simulations, augmented and virtual reality (AR/VR) or biomechanical analysis purposes., The research presented in this paper have been developed within the projects IMDEEA/2020/85 and MDEEA/2020/87. Funding requested to Instituto Valenciano de Competitividad Empresarial (IVACE), call for proposals 2020 for Technology Centers of the Comunitat Valenciana, co-funded by ERDF Funds, EU Operational Program of the Comunitat Valenciana 2014-2020.

We investigate the relation between the number of passes made by a football team and the number of goals. We analyze the 380 matches of a complete season of the Spanish national league &ldquo, LaLiga" (2018/2019). We observe how the number of scored goals is positively correlated with the number of passes made by a team. In this way, teams on the top (bottom) of the ranking at the end of the season make more (less) passes than the rest of the teams. However, we observe a strong asymmetry when the analysis is made depending on the part of the match. Interestingly, fewer passes are made in the second half of a match, while, at the same time, more goals are scored. This paradox appears in the majority of teams, and it is independent of the number of passes made. These results confirm that goals in the first half of matches are more &ldquo, costly&rdquo, in terms of passes than those scored in second halves.

Es bien conocido la apuesta de la educación por la innovación y unas metodologías de aprendizaje que vayan más allá de los recursos tradicionales utilizados dentro de las aulas. El uso de nuevas tecnologías, la incorporación de sonido, imagen y movimiento, crea un nuevo recurso metodológico que permite la integración y participación del alumnado en las actividades de clase. En este trabajo se analizan las ventajas e inconvenientes encontrados durante la ejecución de un proyecto audiovisual en la asignatura “Las Artes Plásticas y Cultura Audiovisual en Educación Primaria” en la Universidad de Jaén, en el que a través de la incorporación de las herramientas digitales más actuales y la disposición de los alumnos en grupos de trabajo se ha logrado fomentar el trabajo cooperativo y el interés de unos estudiantes saturados, en muchas ocasiones, por los trabajos teóricos y las clases magistrales.

Two-antenna systems for wideband amplitude-only direction finding (AODF) are demonstrated. Tapered slot antennas (TSAs) are integrated into two flush-mounted configurations to achieve desired performance over 18–45 GHz range. The first system is made of two TSA elements embedded inside an absorptive cavity. Fed by a 90° hybrid, this phased-array topology supports two squinted beams required for AODF. The second system is made of two identical TSA elements physically squinted off boresight to produce required beams without beamforming. This allows each TSA element to be embedded in a separate nonabsorptive and shaped cavity for much improved AODF including widened field of view, higher gain, better dynamic range, and eliminated sidelobes. The system implications for the use of the proposed antenna front ends in terms of bearing errors to amplitude imbalances and receiver noise are also discussed. The construction of both antenna systems is disclosed, and experimental results closely resembling and therefore verifying theory are obtained.

Background Multiple myeloma (MM) is an incurable hematological neoplasm. However, new therapies have improved overall survival (OS). In relapsed/refractory MM (RRMM) and a resource-limited environment, optimizing treatment options is essential. Autologous hematopoietic stem cell transplantation (ASCT) is an available strategy, frontline and at relapse Objective to analyze overall survival (OS2) and progression-free survival (PFS2) in RRMM patients comparing second-line consolidation strategies. Methods This retrospective survival analysis study, based on the Uruguayan Multiple Myeloma Registry, included all RRMM adult patients Results Fifty-nine patients were included, with a median age at diagnosis of 56 years (IQR 12), 49.1% were male, 70.10% IgG, 84.75% were Durie-Salmon stage (DS) III and 37.3% ISS-III, 27.1% ISS-II, and 30.5% ISS-I. Age, ISS, and DS were not statistically different between therapeutic groups. Most (69.5%) patients had received a first ASCT, and 35.6% received maintenance as first-line therapy. Maintenance therapy was lenalidomide in 20.3%, thalidomide in 6.8%, and 8.5% other options. Eleven patients (18.6%) received salvage ASCT and maintenance, 18.6% received only ASCT, 16.9% received only maintenance and 45.8% neither ASCT nor maintenance. The median OS2 was 34 months, and PFS2 was 26 months. The 3-year OS2 and 3-year PFS2 were 47.2% and 32.2% for the entire cohort, respectively. The combination of ASCT and maintenance achieved a 3-year OS2 of 75.0% whereas OS2 in the non-combined therapy (NCT)(ASCT or maintenance) was 50.7% (HR 0.1, CI95% 0.01 to 0.6, p=0.01). ASCT and maintenance achieved a 3-year PFS2 of 43.1% whereas PFS2 was 37.6% for the NCT (HR 0.2, CI95% 0.1 to 0.7, p=0.01). The 3-year OS2 was 50.7% for those who received ASCT or maintenance vs. 28.4% for those without second-line consolidation (HR 0.3, CI95% 0.2 to 0.9, p=0.02). The 3-year PFS2 was 37.6% for patients who received any of the consolidative strategies vs 19.1% (HR 0.4, CI95% 0.2 to 0.9, p=0.02) in those who did not receive salvage ASCT or maintenance Conclusion ASCT has been recommended for patients relapsing after primary therapy, including an ASCT with an initial remission duration of >18 months. The role of salvage ASCT in patients who received lenalidomide maintenance has not been determined. In our analysis, the combination of ASCT and maintenance improved the OS2 and PFS2 compared to those treated with only ASCT or maintenance. Not receiving second-line consolidation was associated with inferior PFS2 and OS2.

Background: Urinary tract infections (UTI) are among the most common infections in pediatric patients. The main etiopathogenic agent is Escherichia coli. The purpose of this study was to determine the antimicrobial resistance pattern of E. coli in pediatric patients and to understand their main clinical and laboratory manifestations. Methods: Fifty-nine patients were included in the study and classified into two groups: hospitalization (H) and external consultation (EC). Every patient presented urine cultures with the isolation of E. coli that included an antibiogram. Clinical signs and symptoms, urinalysis, complete blood count (CBC) and serum inflammatory markers were analyzed. Results: The most common clinical manifestations were fever (H: 76.5%; EC: 88%), vomiting (H: 32.4%; EC: 32%), hyporexia (H: 20.6%; EC: 16%), abdominal pain (H: 20.6%: EC: 28%), and dysuria (H: 14.7%; EC: 32%). Ten patients (16.95%) presented UTI for extended spectrum beta-lactamase (ESBL) E. coli. Ampicillin, nalidixic acid, and trimethoprim-sulfamethoxazole showed a higher resistance rate, being ampicillin the most significant (H: 88.2%; EC: 92%). Leukocyturia, bacteriuria and urine nitrites were frequent alterations in urinalysis (H: 52.9%; EC: 92%). In ESBL E. coli patients, a positive correlation was found between leukocytes in CBC and C-reactive protein (r = 0.9, p < 0.01). Diarrhea and foul-smelling urine were associated with E. coli resistance. Conclusions: The presence of leukocytes, bacteria, nitrites and the Gram stain are the most common indicators. Nitrofurantoin and phosphomycin are good therapeutic options. However, an antibiogram must be conducted to determine the best therapeutic agent.

An RF exposure of a vehicle's crew is discussed and a fast modeling approach for prediction thereof is demonstrated. The modeling is based on eigenmode analysis for acquiring a range of frequencies where the shielding effectiveness of a vehicle cabin is expected to be significantly worsened. Clear correlation between the positions of eigenfrequencies and high RF exposure peaks obtained by a full-wave analysis is demonstrated. It is shown that cavity resonance behavior may cause consistent overexposure of vehicle's crew compared to the outside people. It is also seen that at lower end very high frequency communication or jamming system can easily violate the Federal Communications Commission set limit for RF exposure.

We quantified the spatial and temporal entropy related to football teams and their players by means of a pass-based interaction. First, we calculated the spatial entropy associated to the positions of all passes made by a football team during a match, obtaining a spatial entropy ranking of Spanish teams during the 2017/2018 season. Second, we investigated how the player&rsquo, s average location in the field is related to the amount of entropy of his passes. Next, we constructed the temporal passing networks of each team and computed the deviation of their network parameters along the match. For each network parameter, we obtained the permutation entropy and the statistical complexity of its temporal fluctuations. Finally, we investigated how the permutation entropy (and statistical complexity) of the network parameters was related to the total number of passes made by a football team. Our results show that (i) spatial entropy changes according to the position of players in the field, and (ii) the organization of passing networks change during a match and its evolution can be captured measuring the permutation entropy and statistical complexity of the network parameters, allowing to identify what parameters evolve more randomly.

Background: Multiple myeloma is a disease of the elderly. However, 40% of patients are diagnosed before 65 years old. Outcomes regarding age as a prognostic factor in MM are heterogeneous. Method: We retrospectively analyzed clinical characteristics, response to treatment and survival of 282 patients with active newly-diagnosed multiple myeloma, comparing results between patients younger and older than 65 years. Main results: The frequency of multiple myeloma in those younger than 66 years was 53.2%. Younger patients presented with a more aggressive disease, more advanced Durie-Salmon stage (85.3% vs 73.5%; p = 0.013), extramedullary disease (12.7% vs 0%; p < 0.001), osteolytic lesions (78.7% vs 57.6%; p < 0.001) and bone plasmacytoma (25.3% vs 11.4%; p = 0.003). In spite of this, the overall response rate was similar between groups (80.6% vs 81.4%; p = 0.866). The overall survival was significantly longer in young patients (median, 65 months vs 41 months; p = 0.001) and higher in those who received autologous hematopoietic stem cell transplantation. The main cause of death was disease progression in both groups. Multivariable analysis revealed that creatinine ≥2 mg/dl, extramedullary disease, ≤very good partial remission and non-autologous hematopoietic stem cell transplantation are independent risk factors for shorter survival. Conclusion: Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation.

BACKGROUND Pulmonary embolism (PE) is a potentially fatal disease related to venous thromboembolism. Information regarding this pathology in the Ecuadorian population is limited. This study aims to present the PE hospital mortality rates (HMR) in Ecuador, analyze its trend and risk factors. METHODS An epidemiological, descriptive and cross-sectional study based on the reporting and trend analysis of pulmonary embolism HMR in the Ecuadorian population from 2011 to 2018 through the governmental database of the Ecuadorian National Statistics and Census Institute, was conducted. RESULTS In Ecuador, PE hospital discharges (HD) varied from 358 in 2011 to 424 in 2018. More than 60% of patients were older than 60 years. Also, the frequency of PE with acute cor pulmonale increased from 3.07% in 2011 to 16.98% in 2018 (P