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Hypoxia in the tumor microenvironment (TME) greatly limits the tumor-killing therapeutic efficacy of sonodynamic therapy (SDT); this phenomenon is further exacerbated by increased glutathione (GSH) levels in cancer cells. Simultaneously, cancer starvation therapy is increasingly recognized nowadays as a promising clinical translation but the efficacy of glucose oxidase (GOx)-based starvation therapy is also limited by the lack of oxygen in the tumor. Glucuronide 3-phosphate dehydrogenase (GADPH) is a key glycolytic enzyme and can therefore be a target for starvation therapy in the absence of oxygen engagement. Here, we innovatively proposed thiol–ene click reactions based on a two-dimensional metal–organic framework (MOF) modification for tumor treatments to enable the combination of SDT and starvation therapy. Experimental studies demonstrated that the prepared material could consume GSH and GADPH free from oxygen in TME, which benefited from the thiol–ene click reactions between the MOF and thiol substances in cancer cells. Further experiments in vitro and in vivo indicated the prepared MOF materials could kill cancer cells efficiently. This study is expected to create a promising avenue for thiol–ene click reactions in SDT therapy and cancer starvation therapy for cancer.

A naked-eye colorimetric chemosensor DK based on benzothiazole could recognize CN- effectively. When DK interacted with CN- in the aqueous solution, the obvious color change of the solution was directly observed by the naked eye. Other anions did not cause any interference. It is interesting that DK could also discriminate Ni2+ from other cations, and the possible interaction mode between them was verified based on the Job's plot, 1H nuclear magnetic resonance titration, infrared , electrospray ionization mass spectrometry, scanning electron microscopy analysis, and density functional theory calculation methods. As a result, it is clear that the mode of action between DK and CN- was different from that between DK and Ni2+. Meanwhile, the limit of detection of DK toward CN- and Ni2+ was calculated to be 1.7 × 10-8 or 7.4 × 10-9 M, respectively. In addition, CN- was recognized qualitatively by a test paper and silica gel plates made from DK. DK was able to detect CN- in tap water quantitatively, rapidly, and on-site by the use of a smartphone APP. All results implied that DK has certain prospects for practical application to identify CN- in water.

The metal corrosion of ballast tank caused by ships ballast water that has been electrolysed has been studied in the laboratory by means of statically immersing metal sample in treated sea water. Experimental tests show that the corrosion rate in the electrolyzed seawater is larger than that in the natural seawater, but the increment of the corrosion rate is not more than 35% in the first 12 hours in the medium with a 5 mg/L initial chlorine concentration and the corrosion rate will decrease with time.

To study the chemical constituents of Ardisia punctata, compounds were isolated with a combination of multi-chromatography. Their structures were determined on the basis of spectral analysis and comparison to those of the known compounds. A 1,4-benzoquinone derivative and a alkylphenol were isolated from the petroleum ether extract of the roots of Ardisia punctata. Their structures were elucidated as 2-tridecyl-3-[(2-tridecyl-4-acetoxy-6-methoxy)-phenoxyl] -6-methoxy-1,4-benzoquinone (1) and 2-methoxy-4-hydroxy-6-tridecyl-phenyl acetate (2). The two compounds are both new.

To study the chemical constituents of Ardisia punctata.Compounds were separated with a combination of multi-chromatography. Their chemical structures were determined on the basis of spectral analysis and single crystal X-ray diffraction.Three compounds were isolated from chloroform extract of the roots of Ardisia punctata. Their structures were elucidated as 2-tridecyl-3-[(2-tridecyl-3-acetoxy-4-methoxy-6-hydroxy) -phenyl]-6-methoxy-1, 4-benzoquinone (1), 2-tridecyl-3-[(2-tridecyl-4,6-dihydroxy) -phenyl]-6-methoxy-1,4-benzoquinone (2) and 2-tridecyl-3-[(2-pentadecyl-4,6-dihydroxyl) -phenyl]-6-methoxy-,4-benzoquinone (3).The three compounds are new 1,4-benzoquinone derivatives.

To study the chemical constituents from the roots of Ardisia punctata.Compounds were isolated by chromatographic techniques on silica gel and Rp-HPLC column. Their structures were elucidated by chemical and spectroscopic methods.Twelve compounds were identified as 3-hydroxy-5-tridecyl-methyl phenyl ether (1), 5-pentadecyl-1, 3-benzenediol (2), 2-methoxy-6-tridecyl-1, 4-benzoquinone (3), 2-methoxy-6-pentadecyl-1, 4-benzoquinone (4), glutinol (5), ardisicrenoside A (6), ardisiacrispin B (7), 24-ethyl-5a-cholesta-7, 22(E)-dien-3-one (8), 24-ethyl-5alpha-cholesta-7, 22(E)-dien-3beta-ol (9), daucosterol (10), vanillin acid (11), tetratriacontanoic acid (12).All the compounds were obtained from this plant for the first time.

To establish a method of the quantitative determination of acetylharpagide in Ajuga decumbens.The chromatographic conditions were as follows: a Phenomenex Luna C18 column was used, the mobile phase was composed of acetontrile-water (15:85), the flow rate was 1.0 mL x min(-1) and the UV absorbance detection was set at 197 nm.Linearity of acetylharpagide was in the range of 0.6-3.6 microg (r = 0.9993), and the average recovery and RSD were 99.13% and 2.48%, respectively.The contents of acetylharpagide ranged 0.40%-6.39% in A. decumbens. The method was simple, accurate and sensitive.

To study the chemical constituents from the roots of Ficus hirta.Compounds were isolated by chromatographic techniques on silica gel and HP-20 resin columns. Their structures were elucidated by chemical and spectroscopic methods.Ten compounds were identified as beta-sitosterol (1), stigmasterol (2), psoralene (3), 3beta-hydroxy-stigmast-5-en-7-one (4), 5-hydroxy-4', 6, 7, 8-tetramethoxy flavone (5), 4', 5, 6, 7, 8-pentamethoxy flavone (6), 4', 5, 7-trihydroxy-flavone (7), 3beta-acetoxy-beta-amyrin (8), 3beta-acetoxy-alpha-amyrin (9) and hesperidin (10).The compounds 4, 5, 6 were obtained from this genus for the first time, and all the compounds were obtained from this plant for the first time.