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In this paper, we obtain a measure of inaccuracy between rth concomitant of generalized order statistic and the parent random variable in Morgenstern family. Applications of this result are given for concomitants of order statistics and record values. We also study some results of cumulative past inaccuracy (CPI) between the distribution function of rth concomitant of order statistic (record value) and the distribution function of parent random variable. Finally, we discuss on a problem of estimating the CPI by means of the empirical CPI in concomitants of generalized order statistics.

Fire in Iranian schools has led to death, serious injury and disability for dozens of students and teachers. The aim of this study was to explore the causes, consequences and lessons learned from school fires in Iran. The available literature, including scientific texts, previous research and media reports, was searched using English and Persian keywords. The keywords were: "students, school, Iran, fire, burn and incidents". No time limitation was imposed. Results showed that 62 school and student dormitory fires have been reported in Iran, of which 14 school fires and 2 student dormitory fires led to human injuries or casualties (25.8%). In these incidents, thirty students (19 girls and 11 boys) and one teacher died. More than 60 students, 8 teachers, and 2 staff suffered burn injuries or disabilities. The main causes of the fire incidents were use of non-standard kerosene heaters (38.7%) and faulty electrical wiring (35.4%). Lack of knowledge about dealing with accidents, inappropriate physical conditions of the school building, lack of fire extinguishers in the building, and carelessness were the main reasons for the deaths and injuries. In conclusion, it is essential to reduce the incidence of fire and prevent its casualties with proper management and standardization of school buildings.Les incendies dans les écoles iraniennes ont tué, gravement blessé et handicapé de nombreux enfants et enseignants. Cette étude a pour but d’explorer les causes, conséquences et implications de ces accidents. Nous effectué une recherche bibliographique, dans les revues scientifiques comme générales, à partir des mots « élèves, école, Iran, incendie, brûlure, accident », sans limite temporelle. Nous avons ainsi trouvé 62 incendies d’école ou de dortoir dont 25,8% responsables de victimes (14 écoles et 2 dortoirs) parmi lesquelles 30 élèves (19 filles, 11 garçons) et 1 enseignants sont morts. Plus de 60 élèves, 8 enseignants et 2 autre membres de l’encadrement ont été brûlés ou handicapés. Les 2 origines les plus fréquentes sont les chauffages à kérosène (38,7%) et les réseaux électriques défectueux (35,4%). Les accidents corporels étaient le plus souvent liés à la méconnaissance des consignes en cas d’incendie, à la vétusté de l’école, à l’absence d’extincteurs, au défaut d’entretien général des bâtiments. La réduction de l’incidence des incendies d’école passe par une réglementation appropriée sur la construction et l’entretien des bâtiments.

UNLABELLED The introduction of HIV-1 protease inhibitor therapy has significantly improved the expectancy and quality of life for HIV-infected patients. Recent reports have highlighted the development of metabolic complications in patients taking protease inhibitors, including abnormalities in glucose metabolism such as impaired glucose tolerance and type 2 diabetes. The mechanisms by which protease inhibitors induce these metabolic syndromes are not well understood. The aim of this study was to determine whether treatment with the HIV-1 protease inhibitor, saquinavir, influences the early insulin signaling cascade in insulin-sensitive cell lines. METHODS Insulin-stimulated phosphorylation of insulin receptor (IR-beta), insulin receptor substrates (IRS-1 and IRS-2), association of phosphatidylinositol 3-kinase (PI 3-kinase), Ser 473-phosphorylation of Akt and Thr202/Tyr204-phosphorylated p44/42 MAP kinase in 3T3L1 adipocytes and FAO hepatoma cells incubated with increasing concentrations of saquinavir for 24, 36 hours, 2, 3 and 6 days were measured. Results. Phosphorylation of IR-beta, IRS-1 and IRS-2 was not permanently affected by incubation with therapeutic doses (2.5 microM) of saquinavir for 36 hours. After 24 hours we observed an increase of IR-beta and IRS-1 phosphorylation. However, this initial stimulation of IR-beta and IRS-1 phosphorylation was not permanent and did not result in an increased PI 3-kinase association. Phosphorylation of IRS-2 and MAP kinase as well as glucose transport activity was not altered by therapeutic doses. Doses of 10, 25 and 50 microM of saquinavir altered the early insulin signaling events in a dose-dependent manner. However, this effect was primarily due to the cytotoxic effect of higher saquinavir doses. Glucose transport activity was not significantly reduced in 3T3L1 cells treated with 2.5 microM saquinavir in comparison to the control cells stimulated with insulin. CONCLUSION Early insulin signaling cascade, essential for normal glucose metabolism, is not affected by therapeutic doses of saquinavir. The reduction of insulin-induced phosphorylation in higher concentrations is primarily related to cytotoxic effects. Other mechanisms than early insulin signaling must be primarily responsible for the metabolic alterations during saquinavir therapy.

Background: Several plants have been shown to possess antioxidant and estrogenic properties that can be useful in postmenopausal bone-loss prevention. The present study aimed to investigate the anti-osteoporotic effects of the hydroalcoholic extract of the Psidium guajava (PG) fruit in ovariectomized (OVX) rats. Methods: Sixty female Sprague–Dawley rats were randomly divided into 6 groups: a control positive group, a sham-operated group, an OVX group given normal saline (OVX-only group), and 3 treatment groups comprising 2 OVX groups treated orally with 500 and 1000 mg/kg/d of the hydroalcoholic extract of the PG fruit respectively and an OVX group treated with an injection of 0.15 mg/kg of estradiol. The study was conducted over a 12-week period. Samples from the animals’ blood, femoral bones, and uteri were collected for stereological and biochemical analyses. The data were analyzed using SPSS, version 19. A P value equal to or less than 0.05 was considered statistically significant. Results: The results revealed a significant decrease in the levels of calcium, total antioxidant capacity, and phosphorus as well as uterus weight, femoral ash density, femoral volume and weight, and numbers of osteocytes and osteoblasts. Moreover, there was an increase in the levels of alkaline phosphatase and urine deoxypyridinoline together with a rise in the number of osteoclasts in the OVX-only group compared to the control and treatment groups (P≤0.05). The hydroalcoholic extract of the PG fruit increased femoral weight and volume, femoral ash density, numbers of osteocytes and osteoblasts, and trabecular volume of the bones in comparison with the OVX-only group in a dose-dependent manner. No significant difference was observed between the groups in the levels of malondialdehyde and interleukin-6. Conclusion: The hydroalcoholic extract of the PG fruit prevented OVX-induced bone loss in the rats, with no proliferative effect on atrophic uteri; it should, therefore, be considered for treatment purposes.

Background: According to the direct connection between congenital hypothyroidism and iodine deficiency in pregnant women, also relatively high incidence of congenital hypothyroidism in some areas of Kerman province, especially Raver district located in North of Kerman province, this study was performed to determine and compare the urinary iodine concentration (UIC) in pregnant women referring to health centers. Methods: This cross-sectional study was done during March 2014 and May 2015. Inclusion and exclusion criteria to be considered and UIC were measured by spectrophotometry in 384 and 374 pregnant women in Ravar and Kerman cities, Iran. Sampling method for this study was all of pregnant women in Ravar and random stratified sampling in Kerman. data were collected using a structured questionnaire. All statistical analyses were performed using SPSS Software, version 20.0 (IBM SPSS, Armonk, NY, USA). Chi-square test, Pearson's correlation coefficient and Logistic regression were used for associations and differences. Results: The mean UIC was 200.21 µg/L in pregnant women of Ravar and 238.79 µg/L in pregnant women of Kerman. 22.7% of pregnant women were with low concentrations of iodine, 57.8% within the normal range and 19.5 percent were with high iodine concentrations in Ravar. While 5.3 percent of pregnant women were with low concentrations of iodine, 54.5% were within the normal range and 40.1% were with high UIC in Kerman. There were no significant differences between demographic variables and UIC in the two regions (P> 05/0). Multivariate regression models showed significant connections between the residence and UIC pregnant women (P< 0.001). Conclusion: The results of this study showed that UIC in pregnant women of Ravar was significantly lower than Kerman and the place of living can be considered as a predictor of UIC in pregnant women.